Brian A. Fuglestad, Ph.D.

Affiliations: 
2013 Chemistry University of California, San Diego, La Jolla, CA 
Area:
Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kinetics
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"Brian Fuglestad"
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Elizabeth A. Komives grad student 2013 UCSD
 (Exploring the Dynamics of Thrombin by NMR.)
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Publications

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MacKenzie DWS, Schaefer A, Steckner J, et al. (2022) A fine balance of hydrophobic-electrostatic communication pathways in a pH-switching protein. Proceedings of the National Academy of Sciences of the United States of America. 119: e2119686119
O'Brien ES, Fuglestad B, Lessen HJ, et al. (2020) Membrane Proteins Have Distinct Fast Internal Motion and Residual Conformational Entropy. Angewandte Chemie (International Ed. in English)
Fuglestad B, Kerstetter NE, Bed'ard S, et al. (2020) Using Reverse Micelles to Extend the Detection Limit of Weak Ligand-Protein Interactions Biophysical Journal. 118
Fuglestad B, Kerstetter NE, Bedard S, et al. (2019) Extending the Detection Limit in Fragment Screening of Proteins using Reverse Micelle Encapsulation. Acs Chemical Biology
Fuglestad B, Kerstetter NE, Wand AJ. (2019) Site-Resolved and Quantitative Characterization of Very Weak Protein-Ligand Interactions. Acs Chemical Biology
Fuglestad B, Marques BS, Jorge C, et al. (2019) Reverse Micelle Encapsulation of Proteins for NMR Spectroscopy. Methods in Enzymology. 615: 43-75
O'Brien ES, Lin DW, Fuglestad B, et al. (2018) Improving yields of deuterated, methyl labeled protein by growing in HO. Journal of Biomolecular Nmr
Fuglestad B, Stetz MA, Belnavis Z, et al. (2017) Solution NMR investigation of the response of the lactose repressor core domain dimer to hydrostatic pressure. Biophysical Chemistry
Handley LD, Fuglestad B, Stearns K, et al. (2017) NMR reveals a dynamic allosteric pathway in thrombin. Scientific Reports. 7: 39575
Fuglestad B, Gupta K, Wand AJ, et al. (2016) Characterization of Cetyl Trimethylammonium Bromide/Hexanol Reverse Micelles by Experimentally Benchmarked Molecular Dynamics Simulations. Langmuir : the Acs Journal of Surfaces and Colloids
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