Tilo J. Kunath, Ph.D. - Publications

Institution:
University of Toronto, Toronto, ON, Canada
Area:
Stem cell research, Molecular genetics, Developmental biology

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Comini G, Kelly R, Jarrin S, Patton T, Narasimhan K, Pandit A, Drummond N, Kunath T, Dowd E. Survival and maturation of human induced pluripotent stem cell-derived dopaminergic progenitors in the Parkinsonian rat brain is enhanced by transplantation in a neurotrophin-enriched hydrogel. Journal of Neural Engineering. PMID 38479026 DOI: 10.1088/1741-2552/ad33b2  0.339
2022 Natalwala A, Behbehani R, Yapom R, Kunath T. An Isogenic Collection of Pluripotent Stem Cell Lines With Elevated α-Synuclein Expression Validated for Neural Induction and Cortical Neuron Differentiation. Frontiers in Cell and Developmental Biology. 10: 898560. PMID 35712660 DOI: 10.3389/fcell.2022.898560  0.405
2022 Elabi OF, Pass R, Sormonta I, Nolbrant S, Drummond N, Kirkeby A, Kunath T, Parmar M, Lane EL. Human Embryonic Stem Cell-Derived Dopaminergic Grafts Alleviate L-DOPA Induced Dyskinesia. Journal of Parkinson's Disease. PMID 35466951 DOI: 10.3233/JPD-212920  0.342
2020 Drummond NJ, Singh Dolt K, Canham MA, Kilbride P, Morris GJ, Kunath T. Cryopreservation of Human Midbrain Dopaminergic Neural Progenitor Cells Poised for Neuronal Differentiation. Frontiers in Cell and Developmental Biology. 8: 578907. PMID 33224948 DOI: 10.3389/fcell.2020.578907  0.433
2020 Chen Y, Kunath T, Simpson J, Homer N, Sylantyev S. Synaptic signalling in a network of dopamine neurons: what prevents proper intercellular crosstalk? Febs Letters. PMID 33073864 DOI: 10.1002/1873-3468.13910  0.331
2020 Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, et al. Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell Death and Differentiation. PMID 32341450 DOI: 10.1038/S41418-020-0542-Z  0.305
2019 Wang Y, Tatham MH, Schmidt-Heck W, Swann C, Singh-Dolt K, Meseguer-Ripolles J, Lucendo-Villarin B, Kunath T, Rudd TR, Smith AJH, Hengstler JG, Godoy P, Hay RT, Hay DC. Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation. Iscience. 16: 206-217. PMID 31185456 DOI: 10.1016/J.Isci.2019.05.028  0.472
2018 Kunath T, Natalwala A, Chan C, Chen Y, Stecher B, Taylor M, Khan S, Muqit MMK. Are PARKIN patients ideal candidates for dopaminergic cell replacement therapies? The European Journal of Neuroscience. PMID 30586214 DOI: 10.1111/Ejn.14314  0.378
2018 Chen Y, Singh Dolt K, Kriek M, Baker T, Downey P, Drummond NJ, Canham MA, Natalwala A, Rosser S, Kunath T. Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene. The European Journal of Neuroscience. PMID 30472757 DOI: 10.1111/Ejn.14286  0.469
2018 Ludtmann MHR, Angelova PR, Horrocks MH, Choi ML, Rodrigues M, Baev AY, Berezhnov AV, Yao Z, Little D, Banushi B, Al-Menhali AS, Ranasinghe RT, Whiten DR, Yapom R, Dolt KS, ... ... Kunath T, et al. α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease. Nature Communications. 9: 2293. PMID 29895861 DOI: 10.1038/S41467-018-04422-2  0.318
2018 Vogt MA, Ehsaei Z, Knuckles P, Higginbottom A, Helmbrecht MS, Kunath T, Eggan K, Williams LA, Shaw PJ, Wurst W, Floss T, Huber AB, Taylor V. TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons. Scientific Reports. 8: 8097. PMID 29802307 DOI: 10.1038/S41598-018-26397-2  0.438
2018 Collo G, Cavalleri L, Bono F, Mora C, Fedele S, Invernizzi RW, Gennarelli M, Piovani G, Kunath T, Millan MJ, Merlo Pich E, Spano P. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plasticity. 2018: 4196961. PMID 29531524 DOI: 10.1155/2018/4196961  0.356
2018 Cavalleri L, Pich EM, Millan MJ, Chiamulera C, Kunath T, Spano PF, Collo G. Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling Molecular Psychiatry. 23: 812-823. PMID 29158584 DOI: 10.1038/Mp.2017.241  0.376
2017 Velasco I, Kunath T, Ramos-Mejía V, Velasco-Velázquez MA. Producing Stem Cell-Based Transplants for Future Therapeutic Purposes. Stem Cells International. 2017: 9592302. PMID 29375626 DOI: 10.1155/2017/9592302  0.418
2017 Drummond NJ, Davies NO, Lovett JE, Miller MR, Cook G, Becker T, Becker CG, McPhail DB, Kunath T. A synthetic cell permeable antioxidant protects neurons against acute oxidative stress. Scientific Reports. 7: 11857. PMID 28928373 DOI: 10.1038/S41598-017-12072-5  0.361
2017 Azami T, Waku T, Matsumoto K, Jeon H, Muratani M, Kawashima A, Yanagisawa J, Manabe I, Nagai R, Kunath T, Nakamura T, Kurimoto K, Saitou M, Takahashi S, Ema M. Klf5 maintains the balance of primitive endoderm to epiblast specification during mouse embryonic development by suppression of Fgf4. Development (Cambridge, England). PMID 28870993 DOI: 10.1242/Dev.150755  0.453
2017 Fedele S, Collo G, Behr K, Bischofberger J, Müller S, Kunath T, Christensen K, Gündner AL, Graf M, Jagasia R, Taylor V. Expansion of human midbrain floor plate progenitors from induced pluripotent stem cells increases dopaminergic neuron differentiation potential. Scientific Reports. 7: 6036. PMID 28729666 DOI: 10.1038/S41598-017-05633-1  0.433
2017 Dolt KS, Hammachi F, Kunath T. Modeling Parkinson's disease with induced pluripotent stem cells harboring α-synuclein mutations. Brain Pathology. 27: 545-551. PMID 28585381 DOI: 10.1111/Bpa.12526  0.318
2017 Natalwala A, Kunath T. Preparation, characterization, and banking of clinical-grade cells for neural transplantation: Scale up, fingerprinting, and genomic stability of stem cell lines. Progress in Brain Research. 230: 133-150. PMID 28552226 DOI: 10.1016/Bs.Pbr.2017.02.007  0.488
2016 Sotthibundhu A, McDonagh K, von Kriegsheim A, Garcia-Munoz A, Klawiter A, Thompson K, Chauhan KD, Krawczyk J, McInerney V, Dockery P, Devine MJ, Kunath T, Barry F, O'Brien T, Shen S. Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells. Stem Cell Research & Therapy. 7: 166. PMID 27846905 DOI: 10.1186/S13287-016-0425-X  0.501
2016 Bergström P, Agholme L, Nazir FH, Satir TM, Toombs J, Wellington H, Strandberg J, Bontell TO, Kvartsberg H, Holmström M, Boreström C, Simonsson S, Kunath T, Lindahl A, Blennow K, et al. Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation. Scientific Reports. 6: 29200. PMID 27383650 DOI: 10.1038/Srep29200  0.347
2015 Canham MA, Van Deusen A, Brison DR, De Sousa PA, Downie J, Devito L, Hewitt ZA, Ilic D, Kimber SJ, Moore HD, Murray H, Kunath T. The Molecular Karyotype of 25 Clinical-Grade Human Embryonic Stem Cell Lines. Scientific Reports. 5: 17258. PMID 26607962 DOI: 10.1038/Srep17258  0.708
2015 Sposito T, Preza E, Mahoney CJ, Setó-Salvia N, Ryan NS, Morris HR, Arber C, Devine MJ, Houlden H, Warner TT, Bushell TJ, Zagnoni M, Kunath T, Livesey FJ, Fox NC, et al. Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT. Human Molecular Genetics. PMID 26136155 DOI: 10.1093/Hmg/Ddv246  0.355
2015 Holmqvist S, Brouwer M, Djelloul M, Diaz AG, Devine MJ, Hammarberg A, Fog K, Kunath T, Roybon L. Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors. Stem Cell Research. 15: 203-20. PMID 26100233 DOI: 10.1016/J.Scr.2015.05.014  0.42
2015 Hayakawa K, Himeno E, Tanaka S, Kunath T. Isolation and manipulation of mouse trophoblast stem cells. Current Protocols in Stem Cell Biology. 32: 1E.4.1-1E.4.32. PMID 25640817 DOI: 10.1002/9780470151808.Sc01E04S32  0.568
2015 Reyes JF, Olsson TT, Lamberts JT, Devine MJ, Kunath T, Brundin P. A cell culture model for monitoring α-synuclein cell-to-cell transfer. Neurobiology of Disease. 77: 266-75. PMID 25046995 DOI: 10.1016/J.Nbd.2014.07.003  0.431
2014 Kunath T, Yamanaka Y, Detmar J, MacPhee D, Caniggia I, Rossant J, Jurisicova A. Developmental differences in the expression of FGF receptors between human and mouse embryos. Placenta. 35: 1079-88. PMID 25443433 DOI: 10.1016/J.Placenta.2014.09.008  0.619
2013 Crompton LA, Byrne ML, Taylor H, Kerrigan TL, Bru-Mercier G, Badger JL, Barbuti PA, Jo J, Tyler SJ, Allen SJ, Kunath T, Cho K, Caldwell MA. Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling. Stem Cell Research. 11: 1206-21. PMID 24013066 DOI: 10.1016/J.Scr.2013.08.002  0.473
2013 Fukuda S, Nagano M, Yamashita T, Kimura K, Tsuboi I, Salazar G, Ueno S, Kondo M, Kunath T, Oshika T, Ohneda O. Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration. Stem Cells (Dayton, Ohio). 31: 2149-61. PMID 23843337 DOI: 10.1002/Stem.1469  0.341
2013 Hamilton WB, Kaji K, Kunath T. ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment. Plos One. 8. PMID 23613754 DOI: 10.1371/Journal.Pone.0060907  0.465
2013 Moerkamp AT, Paca A, Goumans M, Kunath T, Kruithof BPT, Julio MK. Extraembryonic Endoderm cells as a model of endoderm development Development Growth & Differentiation. 55: 301-308. PMID 23414197 DOI: 10.1111/Dgd.12036  0.579
2013 Wray S, Preza E, Rollinson S, Ryten M, Isaacs A, Houlden H, Rossor M, Chio A, Morris H, Pickering-Brown S, Hardy J, Livesey R, Kunath T. O1-01-06: Human stem cell models of frontotemporal dementia caused by a non-coding hexanucleotide repeat expansion in C9ORF72 Alzheimer's & Dementia. 9: P127-P127. DOI: 10.1016/J.Jalz.2013.04.054  0.386
2012 Paca A, Séguin CA, Clements M, Ryczko M, Rossant J, Rodriguez TA, Kunath T. BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm. Developmental Biology. 361: 90-102. PMID 22027433 DOI: 10.1016/J.Ydbio.2011.10.013  0.642
2011 Drummond RJ, Kunath T, Mee PJ, Ross JA. Induced pluripotent stem cell technology and stem cell therapy for diabetes. Experimental and Therapeutic Medicine. 2: 3-7. PMID 22977463 DOI: 10.3892/Etm.2010.173  0.475
2011 Devine MJ, Ryten M, Vodicka P, Thomson AJ, Burdon T, Houlden H, Cavaleri F, Nagano M, Drummond NJ, Taanman JW, Schapira AH, Gwinn K, Hardy J, Lewis PA, Kunath T. Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus. Nature Communications. 2: 440. PMID 21863007 DOI: 10.1038/Ncomms1453  0.42
2011 Kunath T. Primed for pluripotency. Cell Stem Cell. 8: 241-242. PMID 21362560 DOI: 10.1016/J.Stem.2011.02.009  0.543
2010 Wray S, Devine M, Kunath T, Duff K, Morris HR, Houlden H, Rossor MN, Hardy J, Lewis PA. P1-111: Progress towards a neuronal cell model of the tauopathies Alzheimer's & Dementia. 6: S206-S207. DOI: 10.1016/J.Jalz.2010.05.660  0.342
2009 Tzanavari T, Sharov AA, Hall EA, Piao Y, Drummond N, Smith A, Ko MSH, Kunath T. 17-P041 Transcriptome analysis of FGF signalling in embryonic stem cells Mechanisms of Development. 126. DOI: 10.1016/J.Mod.2009.06.762  0.475
2009 Paca A, Kunath T. 13-P090 Generating visceral endoderm from XEN cells Mechanisms of Development. 126. DOI: 10.1016/J.Mod.2009.06.563  0.372
2008 Hayakawa K, Himeno E, Tanaka S, Kunath T. Isolation and Manipulation of Mouse Trophoblast Stem Cells Current Protocols in Stem Cell Biology. 32. PMID 18972374 DOI: 10.1002/9780470151808.Sc01E04S7  0.568
2007 Kunath T, Saba-El-Leil MK, Almousailleakh M, Wray J, Meloche S, Smith A. FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development (Cambridge, England). 134: 2895-902. PMID 17660198 DOI: 10.1242/Dev.02880  0.497
2006 Gladdy RA, Nutter LM, Kunath T, Danska JS, Guidos CJ. p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Molecular Cancer Research : McR. 4: 311-8. PMID 16687486 DOI: 10.1158/1541-7786.Mcr-05-0258  0.324
2006 Quinn J, Kunath T, Rossant J. Mouse trophoblast stem cells Methods in Molecular Medicine. 121: 125-148. PMID 16251740 DOI: 10.1385/1-59259-983-4:123  0.664
2005 Kunath T, Arnaud D, Uy GD, Okamoto I, Chureau C, Yamanaka Y, Heard E, Gardner RL, Avner P, Rossant J. Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development (Cambridge, England). 132: 1649-61. PMID 15753215 DOI: 10.1242/Dev.01715  0.739
2005 Ramos-Mejía V, Escalante-Alcalde D, Kunath T, Ramírez L, Gertsenstein M, Nagy A, Lomelí H. Phenotypic analyses of mouse embryos with ubiquitous expression of Oct4: effects on mid-hindbrain patterning and gene expression. Developmental Dynamics. 232: 180-190. PMID 15580630 DOI: 10.1002/Dvdy.20211  0.425
2004 Kunath T, Strumpf D, Rossant J. Early trophoblast determination and stem cell maintenance in the mouse - A review Placenta. 25: S32-S38. PMID 15033304 DOI: 10.1016/J.Placenta.2004.01.015  0.641
2003 Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T, Aiba K, Akutsu H, ... ... Kunath T, et al. Transcriptome analysis of mouse stem cells and early embryos. Plos Biology. 1: E74. PMID 14691545 DOI: 10.1371/Journal.Pbio.0000074  0.641
2003 Kunath T, Gish G, Lickert H, Jones N, Pawson T, Rossant J. Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype Nature Biotechnology. 21: 559-561. PMID 12679785 DOI: 10.1038/Nbt813  0.533
2002 Tanaka TS, Kunath T, Kimber WL, Jaradat SA, Stagg CA, Usuda M, Yokota T, Niwa H, Rossant J, Ko MS. Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity. Genome Research. 12: 1921-8. PMID 12466296 DOI: 10.1101/Gr.670002  0.631
2001 Tremblay GB, Kunath T, Bergeron D, Lapointe L, Champigny C, Bader JA, Rossant J, Giguère V. Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. Genes & Development. 15: 833-8. PMID 11297507 DOI: 10.1101/Gad.873401  0.605
2001 Kunath T, Strumpf D, Rossant J, Tanaka S. 12 Trophoblast Stem Cells Cold Spring Harbor Monograph Archive. 40: 267-287. DOI: 10.1101/087969673.40.267  0.64
1998 Tanaka S, Kunath T, Hadjantonakis AK, Nagy A, Rossant J. Promotion of Trophoblast Stem Cell Proliferation by FGF4 Science. 282: 2072-2075. PMID 9851926 DOI: 10.1126/Science.282.5396.2072  0.66
1997 Beauchemin N, Kunath T, Robitaille J, Chow B, Turbide C, Daniels E, Veillette A. Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells. Oncogene. 14: 783-90. PMID 9047385 DOI: 10.1038/Sj.Onc.1200888  0.31
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