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Katrin Karbstein, Ph.D. - Publications

Affiliations: 
2003 Stanford University, Palo Alto, CA 
 2006-2010 University of Michigan, Ann Arbor, Ann Arbor, MI 
 2010- Integrative Structural and Computational Biology Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
ribozymes
Website:
https://www.scripps.edu/research/faculty/karbstein
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Yang YM, Karbstein K. The ubiquitin-proteasome system regulates the formation of specialized ribosomes during high salt stress in yeast. Biorxiv : the Preprint Server For Biology. PMID 39185221 DOI: 10.1101/2024.08.15.608112  0.317
2024 Parker MD, Brunk ES, Getzler AJ, Karbstein K. The kinase Rio1 and a ribosome collision-dependent decay pathway survey the integrity of 18S rRNA cleavage. Plos Biology. 22: e3001767. PMID 39038273 DOI: 10.1371/journal.pbio.3001767  0.375
2024 Yang YM, Karbstein K. Ribosome Assembly and Repair. Annual Review of Cell and Developmental Biology. PMID 38724022 DOI: 10.1146/annurev-cellbio-111822-113326  0.337
2023 Blomqvist EK, Huang H, Karbstein K. A disease associated mutant reveals how Ltv1 orchestrates RP assembly and rRNA folding of the small ribosomal subunit head. Plos Genetics. 19: e1010862. PMID 37910572 DOI: 10.1371/journal.pgen.1010862  0.467
2023 Blomqvist EK, Huang H, Karbstein K. A disease associated mutant reveals how Ltv1 orchestrates RP assembly and rRNA folding of the small ribosomal subunit head. Biorxiv : the Preprint Server For Biology. PMID 37503067 DOI: 10.1101/2023.07.10.548325  0.466
2023 Parker MD, Karbstein K. Quality control ensures fidelity in ribosome assembly and cellular health. The Journal of Cell Biology. 222. PMID 36790396 DOI: 10.1083/jcb.202209115  0.338
2022 Karbstein K. Attacking a DEAD problem: The role of DEAD-box ATPases in ribosome assembly and beyond. Methods in Enzymology. 673: 19-38. PMID 35965007 DOI: 10.1016/bs.mie.2022.03.033  0.422
2022 Liu X, Huang H, Karbstein K. Using DMS-MaPseq to Uncover the Roles of DEAD-box Proteins in Ribosome Assembly. Methods (San Diego, Calif.). PMID 35550176 DOI: 10.1016/j.ymeth.2022.05.001  0.419
2022 Huang H, Parker MD, Karbstein K. The modifying enzyme Tsr3 establishes the hierarchy of Rio kinase activity in 40S ribosome assembly. Rna (New York, N.Y.). PMID 35031584 DOI: 10.1261/rna.078994.121  0.52
2021 Huang H, Karbstein K. Assembly factors chaperone ribosomal RNA folding by isolating helical junctions that are prone to misfolding. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34135123 DOI: 10.1073/pnas.2101164118  0.455
2020 Rai J, Parker MD, Huang H, Choy S, Ghalei H, Johnson MC, Karbstein K, Stroupe ME. An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7. Rna (New York, N.Y.). PMID 33219089 DOI: 10.1261/rna.077610.120  0.421
2020 Huang H, Ghalei H, Karbstein K. Quality control of 40S ribosome head assembly ensures scanning competence. The Journal of Cell Biology. 219. PMID 33007085 DOI: 10.1083/jcb.202004161  0.423
2019 Parker MD, Collins JC, Korona B, Ghalei H, Karbstein K. A kinase-dependent checkpoint prevents escape of immature ribosomes into the translating pool. Plos Biology. 17: e3000329. PMID 31834877 DOI: 10.1371/Journal.Pbio.3000329  0.486
2019 Yin Z, Liu X, Ariosa A, Huang H, Jin M, Karbstein K, Klionsky DJ. Psp2, a novel regulator of autophagy that promotes autophagy-related protein translation. Cell Research. PMID 31666677 DOI: 10.1038/S41422-019-0246-4  0.414
2019 Karbstein K. Mitochondria teach ribosome assembly. Science (New York, N.Y.). 365: 1077-1078. PMID 31515371 DOI: 10.1126/Science.Aay7771  0.389
2019 Khoshnevis S, Liu X, Dattolo M, Karbstein K. Rrp5 Establishes a Checkpoint for 60S Assembly During 40S Maturation. Rna (New York, N.Y.). PMID 31217256 DOI: 10.1261/Rna.071225.119  0.563
2019 Ferretti MB, Karbstein K. Does Functional Specialization of Ribosomes Really Exist? Rna (New York, N.Y.). PMID 30733326 DOI: 10.1261/Rna.069823.118  0.436
2018 Collins JC, Ghalei H, Doherty JR, Huang H, Culver RN, Karbstein K. Ribosome biogenesis factor Ltv1 chaperones the assembly of the small subunit head. The Journal of Cell Biology. PMID 30348748 DOI: 10.1083/Jcb.201804163  0.497
2018 Ferretti MB, Barre JL, Karbstein K. Translational Reprogramming Provides a Blueprint for Cellular Adaptation. Cell Chemical Biology. PMID 30174311 DOI: 10.1016/J.Chembiol.2018.08.003  0.336
2017 Ghalei H, Trepreau J, Collins JC, Bhaskaran H, Strunk BS, Karbstein K. The ATPase Fap7 Tests the Ability to Carry Out Translocation-like Conformational Changes and Releases Dim1 during 40S Ribosome Maturation. Molecular Cell. 68: 1155. PMID 29272706 DOI: 10.1016/j.molcel.2017.12.001  0.701
2017 Ghalei H, Trepreau J, Collins JC, Bhaskaran H, Strunk BS, Karbstein K. The ATPase Fap7 Tests the Ability to Carry Out Translocation-like Conformational Changes and Releases Dim1 during 40S Ribosome Maturation. Molecular Cell. PMID 28890337 DOI: 10.1016/J.Molcel.2017.08.007  0.765
2017 Ferretti MB, Ghalei H, Ward EA, Potts EL, Karbstein K. Rps26 directs mRNA-specific translation by recognition of Kozak sequence elements. Nature Structural & Molecular Biology. PMID 28759050 DOI: 10.1038/Nsmb.3442  0.396
2017 Johnson MC, Ghalei H, Doxtader KA, Karbstein K, Stroupe ME. Structural Heterogeneity in Pre-40S Ribosomes. Structure (London, England : 1993). PMID 28111018 DOI: 10.1016/J.Str.2016.12.011  0.443
2016 Khoshnevis S, Askenasy I, Johnson MC, Dattolo MD, Young-Erdos CL, Stroupe ME, Karbstein K. The DEAD-box Protein Rok1 Orchestrates 40S and 60S Ribosome Assembly by Promoting the Release of Rrp5 from Pre-40S Ribosomes to Allow for 60S Maturation. Plos Biology. 14: e1002480. PMID 27280440 DOI: 10.1371/Journal.Pbio.1002480  0.571
2015 Karbstein K. What will the future hold: RNP quality control and degradation. Rna (New York, N.Y.). 21: 657-8. PMID 25780179 DOI: 10.1261/Rna.050658.115  0.582
2015 Ghalei H, Schaub FX, Doherty JR, Noguchi Y, Roush WR, Cleveland JL, Stroupe ME, Karbstein K. Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth. The Journal of Cell Biology. 208: 745-59. PMID 25778921 DOI: 10.1083/Jcb.201409056  0.425
2015 de la Cruz J, Karbstein K, Woolford JL. Functions of ribosomal proteins in assembly of eukaryotic ribosomes in vivo. Annual Review of Biochemistry. 84: 93-129. PMID 25706898 DOI: 10.1146/Annurev-Biochem-060614-033917  0.554
2015 Tyagi R, Shahani N, Gorgen L, Ferretti M, Pryor W, Chen PY, Swarnkar S, Worley PF, Karbstein K, Snyder SH, Subramaniam S. Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade. Cell Reports. PMID 25660019 DOI: 10.1016/J.Celrep.2015.01.014  0.362
2015 Johnson MC, Ghalei H, Karbstein K, Stroupe ME. Heterogeneity in the pre-40S ribosomal subunit reveals two distinct regions of variation at functionally important structural elements Microscopy and Microanalysis. 21: 53-54. DOI: 10.1017/S1431927615001063  0.328
2013 Young CL, Khoshnevis S, Karbstein K. Cofactor-dependent specificity of a DEAD-box protein. Proceedings of the National Academy of Sciences of the United States of America. 110: E2668-76. PMID 23630256 DOI: 10.1073/Pnas.1302577110  0.504
2013 Karbstein K. Quality control mechanisms during ribosome maturation. Trends in Cell Biology. 23: 242-50. PMID 23375955 DOI: 10.1016/J.Tcb.2013.01.004  0.476
2012 Strunk BS, Novak MN, Young CL, Karbstein K. A translation-like cycle is a quality control checkpoint for maturing 40S ribosome subunits. Cell. 150: 111-21. PMID 22770215 DOI: 10.1016/J.Cell.2012.04.044  0.766
2012 Young C, Karbstein K. Analysis of cofactor effects on RNA helicases. Methods in Enzymology. 511: 213-37. PMID 22713322 DOI: 10.1016/B978-0-12-396546-2.00010-3  0.442
2011 Karbstein K. Inside the 40S ribosome assembly machinery. Current Opinion in Chemical Biology. 15: 657-63. PMID 21862385 DOI: 10.1016/J.Cbpa.2011.07.023  0.536
2011 Horn DM, Mason SL, Karbstein K. Rcl1 protein, a novel nuclease for 18 S ribosomal RNA production. The Journal of Biological Chemistry. 286: 34082-7. PMID 21849504 DOI: 10.1074/Jbc.M111.268649  0.509
2011 Strunk BS, Loucks CR, Su M, Vashisth H, Cheng S, Schilling J, Brooks CL, Karbstein K, Skiniotis G. Ribosome assembly factors prevent premature translation initiation by 40S assembly intermediates. Science (New York, N.Y.). 333: 1449-53. PMID 21835981 DOI: 10.1126/Science.1208245  0.768
2011 Campbell MG, Karbstein K. Protein-protein interactions within late pre-40S ribosomes. Plos One. 6: e16194. PMID 21283762 DOI: 10.1371/Journal.Pone.0016194  0.752
2011 Young CL, Karbstein K. The roles of S1 RNA-binding domains in Rrp5's interactions with pre-rRNA. Rna (New York, N.Y.). 17: 512-21. PMID 21233221 DOI: 10.1261/Rna.2458811  0.491
2011 Woolls HA, Lamanna AC, Karbstein K. Roles of Dim2 in ribosome assembly. The Journal of Biological Chemistry. 286: 2578-86. PMID 21075849 DOI: 10.1074/Jbc.M110.191494  0.526
2011 Lamanna AC, Karbstein K. An RNA conformational switch regulates pre-18S rRNA cleavage. Journal of Molecular Biology. 405: 3-17. PMID 20934433 DOI: 10.1016/J.Jmb.2010.09.064  0.505
2010 Karbstein K. Chaperoning ribosome assembly. The Journal of Cell Biology. 189: 11-2. PMID 20368615 DOI: 10.1083/Jcb.201002102  0.376
2009 Strunk BS, Karbstein K. Powering through ribosome assembly. Rna (New York, N.Y.). 15: 2083-104. PMID 19850913 DOI: 10.1261/Rna.1792109  0.759
2009 Lamanna AC, Karbstein K. Nob1 binds the single-stranded cleavage site D at the 3'-end of 18S rRNA with its PIN domain. Proceedings of the National Academy of Sciences of the United States of America. 106: 14259-64. PMID 19706509 DOI: 10.1073/Pnas.0905403106  0.536
2007 Todd G, Karbstein K. RNA takes center stage. Biopolymers. 87: 275-8. PMID 17688253 DOI: 10.1002/Bip.20824  0.346
2007 Karbstein K. Role of GTPases in ribosome assembly. Biopolymers. 87: 1-11. PMID 17514744 DOI: 10.1002/Bip.20762  0.46
2007 Karbstein K, Lee J, Herschlag D. Probing the role of a secondary structure element at the 5'- and 3'-splice sites in group I intron self-splicing: the tetrahymena L-16 ScaI ribozyme reveals a new role of the G.U pair in self-splicing. Biochemistry. 46: 4861-75. PMID 17385892 DOI: 10.1021/Bi062169G  0.6
2006 Karbstein K, Doudna JA. GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis. Journal of Molecular Biology. 356: 432-43. PMID 16376378 DOI: 10.1016/J.Jmb.2005.11.052  0.695
2005 Karbstein K, Jonas S, Doudna JA. An essential GTPase promotes assembly of preribosomal RNA processing complexes. Molecular Cell. 20: 633-43. PMID 16307926 DOI: 10.1016/J.Molcel.2005.09.017  0.678
2004 Karbstein K, Tang KH, Herschlag D. A base triple in the Tetrahymena group I core affects the reaction equilibrium via a threshold effect. Rna (New York, N.Y.). 10: 1730-9. PMID 15496521 DOI: 10.1261/Rna.7118104  0.596
2004 Karbstein K, Doudna JA. RNA: primed for packing? Chemistry & Biology. 11: 149-51. PMID 15123272 DOI: 10.1016/J.Chembiol.2004.02.007  0.539
2003 Karbstein K, Herschlag D. Extraordinarily slow binding of guanosine to the Tetrahymena group I ribozyme: implications for RNA preorganization and function. Proceedings of the National Academy of Sciences of the United States of America. 100: 2300-5. PMID 12591943 DOI: 10.1073/Pnas.252749799  0.595
2002 Karbstein K, Carroll KS, Herschlag D. Probing the Tetrahymena group I ribozyme reaction in both directions. Biochemistry. 41: 11171-83. PMID 12220182 DOI: 10.1021/Bi0202631  0.557
1999 Wang S, Karbstein K, Peracchi A, Beigelman L, Herschlag D. Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate. Biochemistry. 38: 14363-78. PMID 10572011 DOI: 10.1021/Bi9913202  0.526
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