David Bowtell - Publications

Affiliations: 
 

188 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Pharoah PD, Song H, Dicks E, Intermaggio MP, Harrington P, Baynes C, Alsop K, Bogdanova N, Cicek MS, Cunningham JM, Fridley BL, Gentry-Maharaj A, Hillemanns P, Lele S, ... ... Bowtell DD, et al. PPM1D Mosaic Truncating Variants in Ovarian Cancer Cases May Be Treatment-Related Somatic Mutations. Journal of the National Cancer Institute. 108. PMID 26823519 DOI: 10.1093/jnci/djv347  1
2015 Wong SQ, Waldeck K, Vergara IA, Schröder J, Madore J, Wilmott JS, Colebatch AJ, De Paoli-Iseppi R, Li J, Lupat R, Semple T, Arnau GM, Fellowes A, Leonard JH, Hruby G, ... ... Bowtell DD, et al. UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas. Cancer Research. PMID 26627015 DOI: 10.1158/0008-5472.CAN-15-1877  1
2015 Kondrashova O, Love CJ, Lunke S, Hsu AL, Waring PM, Taylor GR. High-Throughput Amplicon-Based Copy Number Detection of 11 Genes in Formalin-Fixed Paraffin-Embedded Ovarian Tumour Samples by MLPA-Seq. Plos One. 10: e0143006. PMID 26569395 DOI: 10.1371/journal.pone.0143006  1
2015 Hunter SM, Anglesio MS, Ryland GL, Sharma R, Chiew YE, Rowley SM, Doyle MA, Li J, Gilks CB, Moss P, Allan PE, Stephens AN, Huntsman DG, deFazio A, Bowtell DD, et al. Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes. Oncotarget. PMID 26506417 DOI: 10.18632/oncotarget.5438  1
2015 Patch AM, Christie EL, Etemadmoghadam D, Garsed DW, George J, Fereday S, Nones K, Cowin P, Alsop K, Bailey PJ, Kassahn KS, Newell F, Quinn MC, Kazakoff S, Quek K, ... ... Bowtell DD, et al. Corrigendum: Whole-genome characterization of chemoresistant ovarian cancer. Nature. PMID 26503049 DOI: 10.1038/nature15716  1
2015 Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, Brenton JD, Chiappinelli KB, Martins FC, Coukos G, Drapkin R, et al. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. Nature Reviews. Cancer. 15: 668-79. PMID 26493647 DOI: 10.1038/nrc4019  1
2015 Kilroy G, Carter LE, Newman S, Burk DH, Manuel J, Möller A, Bowtell DD, Mynatt RL, Ghosh S, Floyd ZE. The ubiquitin ligase Siah2 regulates obesity-induced adipose tissue inflammation. Obesity (Silver Spring, Md.). PMID 26380945 DOI: 10.1002/oby.21220  1
2015 Karnezis AN, Wang Y, Ramos P, Hendricks WP, Oliva E, D'Angelo E, Prat J, Nucci MR, Nielsen TO, Chow C, Leung S, Kommoss F, Kommoss S, Silva A, Ronnett BM, ... ... Bowtell DD, et al. Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcemic type. The Journal of Pathology. PMID 26356327 DOI: 10.1002/path.4633  1
2015 Ramus SJ, Song H, Dicks E, Tyrer JP, Rosenthal AN, Intermaggio MP, Fraser L, Gentry-Maharaj A, Hayward J, Philpott S, Anderson C, Edlund CK, Conti D, Harrington P, Barrowdale D, ... Bowtell DD, et al. Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer. Journal of the National Cancer Institute. 107. PMID 26315354 DOI: 10.1093/jnci/djv214  1
2015 Song H, Dicks E, Ramus SJ, Tyrer JP, Intermaggio MP, Hayward J, Edlund CK, Conti D, Harrington P, Fraser L, Philpott S, Anderson C, Rosenthal A, Gentry-Maharaj A, Bowtell DD, et al. Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 2901-7. PMID 26261251 DOI: 10.1200/JCO.2015.61.2408  1
2015 Ryland GL, Hunter SM, Doyle MA, Caramia F, Li J, Rowley SM, Christie M, Allan PE, Stephens AN, Bowtell DD, Campbell IG, Gorringe KL. Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors. Genome Medicine. 7: 87. PMID 26257827 DOI: 10.1186/s13073-015-0210-y  1
2015 Ryland GL, Doyle MA, Goode D, Boyle SE, Choong DY, Rowley SM, Li J, Bowtell DD, Tothill RW, Campbell IG, Gorringe KL. Loss of heterozygosity: what is it good for? Bmc Medical Genomics. 8: 45. PMID 26231170 DOI: 10.1186/s12920-015-0123-z  1
2015 Davis SJ, Sheppard KE, Anglesio MS, George J, Traficante N, Fereday S, Intermaggio MP, Menon U, Gentry-Maharaj A, Lubinski J, Gronwald J, Pearce CL, Pike MC, Wu A, Kommoss S, ... ... Bowtell DD, et al. Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition. Molecular Cancer Therapeutics. 14: 1495-503. PMID 25852062 DOI: 10.1158/1535-7163.MCT-15-0039  1
2015 Leong HS, Galletta L, Etemadmoghadam D, George J, Köbel M, Ramus SJ, Bowtell D. Efficient molecular subtype classification of high-grade serous ovarian cancer. The Journal of Pathology. 236: 272-7. PMID 25810134 DOI: 10.1002/path.4536  1
2015 Milagre CS, Gopinathan G, Everitt G, Thompson RG, Kulbe H, Zhong H, Hollingsworth RE, Grose R, Bowtell DD, Hochhauser D, Balkwill FR. Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer. Cancer Research. 75: 1255-64. PMID 25670170 DOI: 10.1158/0008-5472.CAN-14-1801  1
2015 Chen A, Wong CS, Liu MC, House CM, Sceneay J, Bowtell DD, Thompson EW, Möller A. The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer. Oncotarget. 6: 862-73. PMID 25528765  1
2015 Tothill RW, Shi F, Paiman L, Bedo J, Kowalczyk A, Mileshkin L, Buela E, Klupacs R, Bowtell D, Byron K. Development and validation of a gene expression tumour classifier for cancer of unknown primary. Pathology. 47: 7-12. PMID 25485653 DOI: 10.1097/PAT.0000000000000194  1
2015 Candido-dos-Reis FJ, Song H, Goode EL, Cunningham JM, Fridley BL, Larson MC, Alsop K, Dicks E, Harrington P, Ramus SJ, de Fazio A, Mitchell G, Fereday S, Bolton KL, Gourley C, ... ... Bowtell D, et al. Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 652-7. PMID 25398451 DOI: 10.1158/1078-0432.CCR-14-2497  1
2015 Crook A, Plunkett L, Forrest LE, Hallowell N, Wake S, Alsop K, Gleeson M, Bowtell D, Mitchell G, Young MA. Connecting patients, researchers and clinical genetics services: the experiences of participants in the Australian Ovarian Cancer Study (AOCS). European Journal of Human Genetics : Ejhg. 23: 152-8. PMID 24824132 DOI: 10.1038/ejhg.2014.86  1
2015 Guccione L, Mileshkin L, Schofield P, Bowtell D. Carcinoma of unknown primary - Rare but ripe for help from genomics? Cancer Forum. 39: 44-46.  1
2014 Etemadmoghadam D, Bowtell D. AKT1 gene amplification as a biomarker of treatment response in ovarian cancer: mounting evidence of a therapeutic target. Gynecologic Oncology. 135: 409-10. PMID 25498304 DOI: 10.1016/j.ygyno.2014.11.007  1
2014 Köbel M, Madore J, Ramus SJ, Clarke BA, Pharoah PD, Deen S, Bowtell DD, Odunsi K, Menon U, Morrison C, Lele S, Bshara W, Sucheston L, Beckmann MW, Hein A, et al. Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study. British Journal of Cancer. 111: 2297-307. PMID 25349970 DOI: 10.1038/bjc.2014.567  1
2014 Emmanuel C, Chiew YE, George J, Etemadmoghadam D, Anglesio MS, Sharma R, Russell P, Kennedy C, Fereday S, Hung J, Galletta L, Hogg R, Wain GV, Brand A, Balleine R, ... ... Bowtell DD, et al. Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 6618-30. PMID 25316818 DOI: 10.1158/1078-0432.CCR-14-1292  1
2014 Kenny HA, Chiang CY, White EA, Schryver EM, Habis M, Romero IL, Ladanyi A, Penicka CV, George J, Matlin K, Montag A, Wroblewski K, Yamada SD, Mazar AP, Bowtell D, et al. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. The Journal of Clinical Investigation. 124: 4614-28. PMID 25202979 DOI: 10.1172/JCI74778  1
2014 Bowtell DD, Drapkin R. Highlights from the 2014 American Association for Cancer Research Annual Meeting. Gynecologic Oncology. 134: 3-5. PMID 25089320 DOI: 10.1016/j.ygyno.2014.05.027  1
2014 Hedditch EL, Gao B, Russell AJ, Lu Y, Emmanuel C, Beesley J, Johnatty SE, Chen X, Harnett P, George J, Williams RT, Flemming C, Lambrechts D, Despierre E, ... ... Bowtell DD, et al. ABCA transporter gene expression and poor outcome in epithelial ovarian cancer. Journal of the National Cancer Institute. 106. PMID 24957074 DOI: 10.1093/jnci/dju149  1
2014 Gao B, Russell A, Beesley J, Chen XQ, Healey S, Henderson M, Wong M, Emmanuel C, Galletta L, Johnatty SE, Bowtell D, Haber M, Norris M, Harnett P, et al. Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer. Scientific Reports. 4: 4669. PMID 24810093 DOI: 10.1038/srep04669  1
2014 Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA. Fine tuning of the UPR by the ubiquitin ligases Siah1/2. Plos Genetics. 10: e1004348. PMID 24809345 DOI: 10.1371/journal.pgen.1004348  1
2014 Cooke SL, Shlien A, Marshall J, Pipinikas CP, Martincorena I, Tubio JM, Li Y, Menzies A, Mudie L, Ramakrishna M, Yates L, Davies H, Bolli N, Bignell GR, Tarpey PS, ... ... Bowtell D, et al. Processed pseudogenes acquired somatically during cancer development. Nature Communications. 5: 3644. PMID 24714652 DOI: 10.1038/ncomms4644  1
2014 Topp MD, Hartley L, Cook M, Heong V, Boehm E, McShane L, Pyman J, McNally O, Ananda S, Harrell M, Etemadmoghadam D, Galletta L, Alsop K, Mitchell G, Fox SB, ... ... Bowtell DD, et al. Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts. Molecular Oncology. 8: 656-68. PMID 24560445 DOI: 10.1016/j.molonc.2014.01.008  1
2014 Karst AM, Jones PM, Vena N, Ligon AH, Liu JF, Hirsch MS, Etemadmoghadam D, Bowtell DD, Drapkin R. Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers. Cancer Research. 74: 1141-52. PMID 24366882 DOI: 10.1158/0008-5472.CAN-13-2247  1
2014 Kim H, Claps G, Möller A, Bowtell D, Lu X, Ronai ZA. Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability. Oncogene. 33: 2004-10. PMID 23644657 DOI: 10.1038/onc.2013.149  1
2013 Etemadmoghadam D, Weir BA, Au-Yeung G, Alsop K, Mitchell G, George J, Davis S, D'Andrea AD, Simpson K, Hahn WC, Bowtell DD. Synthetic lethality between CCNE1 amplification and loss of BRCA1. Proceedings of the National Academy of Sciences of the United States of America. 110: 19489-94. PMID 24218601 DOI: 10.1073/pnas.1314302110  1
2013 Tothill RW, Li J, Mileshkin L, Doig K, Siganakis T, Cowin P, Fellowes A, Semple T, Fox S, Byron K, Kowalczyk A, Thomas D, Schofield P, Bowtell DD. Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary. The Journal of Pathology. 231: 413-23. PMID 24037760 DOI: 10.1002/path.4251  1
2013 Sheppard KE, Cullinane C, Hannan KM, Wall M, Chan J, Barber F, Foo J, Cameron D, Neilsen A, Ng P, Ellul J, Kleinschmidt M, Kinross KM, Bowtell DD, Christensen JG, et al. Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors. European Journal of Cancer (Oxford, England : 1990). 49: 3936-44. PMID 24011934 DOI: 10.1016/j.ejca.2013.08.007  1
2013 Etemadmoghadam D, Au-Yeung G, Wall M, Mitchell C, Kansara M, Loehrer E, Batzios C, George J, Ftouni S, Weir BA, Carter S, Gresshoff I, Mileshkin L, Rischin D, Hahn WC, ... ... Bowtell DD, et al. Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 5960-71. PMID 24004674 DOI: 10.1158/1078-0432.CCR-13-1337  1
2013 George J, Gorringe KL, Smyth GK, Bowtell DD. Identifying associations between genomic alterations in tumors. Methods in Molecular Biology (Clifton, N.J.). 1049: 9-19. PMID 23913205 DOI: 10.1007/978-1-62703-547-7_2  1
2013 Sieh W, Köbel M, Longacre TA, Bowtell DD, deFazio A, Goodman MT, Høgdall E, Deen S, Wentzensen N, Moysich KB, Brenton JD, Clarke BA, Menon U, Gilks CB, Kim A, et al. Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study. The Lancet. Oncology. 14: 853-62. PMID 23845225 DOI: 10.1016/S1470-2045(13)70253-5  1
2013 Sceneay J, Liu MC, Chen A, Wong CS, Bowtell DD, Möller A. The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo. Plos One. 8: e66388. PMID 23840457 DOI: 10.1371/journal.pone.0066388  1
2013 George J, Alsop K, Etemadmoghadam D, Hondow H, Mikeska T, Dobrovic A, deFazio A, Smyth GK, Levine DA, Mitchell G, Bowtell DD. Nonequivalent gene expression and copy number alterations in high-grade serous ovarian cancers with BRCA1 and BRCA2 mutations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 3474-84. PMID 23633455 DOI: 10.1158/1078-0432.CCR-13-0066  1
2013 Musyoka JN, Liu MC, Pouniotis DS, Wong CS, Bowtell DD, Little PJ, Getachew R, Möller A, Darby IA. Siah2-deficient mice show impaired skin wound repair. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 21: 437-47. PMID 23627548 DOI: 10.1111/wrr.12045  1
2013 Mikeska T, Alsop K, Mitchell G, Bowtell DD, Dobrovic A. No evidence for PALB2 methylation in high-grade serous ovarian cancer. Journal of Ovarian Research. 6: 26. PMID 23587053 DOI: 10.1186/1757-2215-6-26  1
2013 Qi J, Tripathi M, Mishra R, Sahgal N, Fazli L, Fazil L, Ettinger S, Placzek WJ, Claps G, Chung LW, Bowtell D, Gleave M, Bhowmick N, Ronai ZA. The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity. Cancer Cell. 23: 332-46. PMID 23518348 DOI: 10.1016/j.ccr.2013.02.016  1
2013 Kondalsamy-Chennakesavan S, Hackethal A, Bowtell D, Obermair A. Differentiating stage 1 epithelial ovarian cancer from benign ovarian tumours using a combination of tumour markers HE4, CA125, and CEA and patient's age. Gynecologic Oncology. 129: 467-71. PMID 23500084 DOI: 10.1016/j.ygyno.2013.03.001  1
2013 Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, et al. Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell. 152: 1008-20. PMID 23452850 DOI: 10.1016/j.cell.2013.01.056  1
2013 Hallowell N, Alsop K, Gleeson M, Crook A, Plunkett L, Bowtell D, Mitchell G, Young MA. The responses of research participants and their next of kin to receiving feedback of genetic test results following participation in the Australian Ovarian Cancer Study. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 15: 458-65. PMID 23448721 DOI: 10.1038/gim.2012.154  1
2013 Baumbusch LO, Helland Å, Wang Y, Liestøl K, Schaner ME, Holm R, Etemadmoghadam D, Alsop K, Brown P, Mitchell G, Fereday S, DeFazio A, Bowtell DD, Kristensen GB, et al. High levels of genomic aberrations in serous ovarian cancers are associated with better survival. Plos One. 8: e54356. PMID 23372714 DOI: 10.1371/journal.pone.0054356  1
2013 Verhaak RG, Tamayo P, Yang JY, Hubbard D, Zhang H, Creighton CJ, Fereday S, Lawrence M, Carter SL, Mermel CH, Kostic AD, Etemadmoghadam D, Saksena G, Cibulskis K, Duraisamy S, ... ... Bowtell DD, et al. Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. The Journal of Clinical Investigation. 123: 517-25. PMID 23257362 DOI: 10.1172/JCI65833  1
2013 Ryland GL, Hunter SM, Doyle MA, Rowley SM, Christie M, Allan PE, Bowtell DD, Gorringe KL, Campbell IG. RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary. The Journal of Pathology. 229: 469-76. PMID 23096461 DOI: 10.1002/path.4134  1
2013 Anglesio MS, Kommoss S, Tolcher MC, Clarke B, Galletta L, Porter H, Damaraju S, Fereday S, Winterhoff BJ, Kalloger SE, Senz J, Yang W, Steed H, Allo G, Ferguson S, ... ... Bowtell DD, et al. Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas. The Journal of Pathology. 229: 111-20. PMID 22899400 DOI: 10.1002/path.4088  1
2012 Sawyer S, Mitchell G, McKinley J, Chenevix-Trench G, Beesley J, Chen XQ, Bowtell D, Trainer AH, Harris M, Lindeman GJ, James PA. A role for common genomic variants in the assessment of familial breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 4330-6. PMID 23109704 DOI: 10.1200/JCO.2012.41.7469  1
2012 Wang ZC, Birkbak NJ, Culhane AC, Drapkin R, Fatima A, Tian R, Schwede M, Alsop K, Daniels KE, Piao H, Liu J, Etemadmoghadam D, Miron A, Salvesen HB, Mitchell G, ... ... Bowtell DD, et al. Profiles of genomic instability in high-grade serous ovarian cancer predict treatment outcome. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 5806-15. PMID 22912389 DOI: 10.1158/1078-0432.CCR-12-0857  1
2012 Cowin PA, George J, Fereday S, Loehrer E, Van Loo P, Cullinane C, Etemadmoghadam D, Ftouni S, Galletta L, Anglesio MS, Hendley J, Bowes L, Sheppard KE, Christie EL, Pearson RB, ... ... Bowtell DD, et al. LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin. Cancer Research. 72: 4060-73. PMID 22896685 DOI: 10.1158/0008-5472.CAN-12-0203  1
2012 Hunter SM, Gorringe KL, Christie M, Rowley SM, Bowtell DD, Campbell IG. Pre-invasive ovarian mucinous tumors are characterized by CDKN2A and RAS pathway aberrations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 5267-77. PMID 22891197 DOI: 10.1158/1078-0432.CCR-12-1103  1
2012 Sceneay J, Chow MT, Chen A, Halse HM, Wong CS, Andrews DM, Sloan EK, Parker BS, Bowtell DD, Smyth MJ, Möller A. Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche. Cancer Research. 72: 3906-11. PMID 22751463 DOI: 10.1158/0008-5472.CAN-11-3873  1
2012 Alsop K, Fereday S, Meldrum C, deFazio A, Emmanuel C, George J, Dobrovic A, Birrer MJ, Webb PM, Stewart C, Friedlander M, Fox S, Bowtell D, Mitchell G. BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 2654-63. PMID 22711857 DOI: 10.1200/JCO.2011.39.8545  1
2012 Berns EM, Bowtell DD. The changing view of high-grade serous ovarian cancer. Cancer Research. 72: 2701-4. PMID 22593197 DOI: 10.1158/0008-5472.CAN-11-3911  1
2012 McBride DJ, Etemadmoghadam D, Cooke SL, Alsop K, George J, Butler A, Cho J, Galappaththige D, Greenman C, Howarth KD, Lau KW, Ng CK, Raine K, Teague J, Wedge DC, ... ... Bowtell DD, et al. Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes. The Journal of Pathology. 227: 446-55. PMID 22514011 DOI: 10.1002/path.4042  1
2012 Wong CS, Sceneay J, House CM, Halse HM, Liu MC, George J, Hunnam TC, Parker BS, Haviv I, Ronai Z, Cullinane C, Bowtell DD, Möller A. Vascular normalization by loss of Siah2 results in increased chemotherapeutic efficacy. Cancer Research. 72: 1694-704. PMID 22354750 DOI: 10.1158/0008-5472.CAN-11-3310  1
2012 Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Salako MA, Smyth JF, Hagemann T, ... ... Bowtell DD, et al. A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. Cancer Research. 72: 66-75. PMID 22065722 DOI: 10.1158/0008-5472.CAN-11-2178  1
2011 Kim H, Scimia MC, Wilkinson D, Trelles RD, Wood MR, Bowtell D, Dillin A, Mercola M, Ronai ZA. Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Molecular Cell. 44: 532-44. PMID 22099302 DOI: 10.1016/j.molcel.2011.08.045  1
2011 Vaughan S, Coward JI, Bast RC, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, Friedlander M, Gabra H, Kaye SB, Lord CJ, Lengyel E, ... ... Bowtell DD, et al. Rethinking ovarian cancer: recommendations for improving outcomes. Nature Reviews. Cancer. 11: 719-25. PMID 21941283 DOI: 10.1038/nrc3144  1
2011 Figueroa JD, Garcia-Closas M, Humphreys M, Platte R, Hopper JL, Southey MC, Apicella C, Hammet F, Schmidt MK, Broeks A, Tollenaar RA, Van't Veer LJ, Fasching PA, Beckmann MW, Ekici AB, et al. Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium. Human Molecular Genetics. 20: 4693-706. PMID 21852249 DOI: 10.1093/hmg/ddr368  1
2011 Stany MP, Vathipadiekal V, Ozbun L, Stone RL, Mok SC, Xue H, Kagami T, Wang Y, McAlpine JN, Bowtell D, Gout PW, Miller DM, Gilks CB, Huntsman DG, Ellard SL, et al. Identification of novel therapeutic targets in microdissected clear cell ovarian cancers. Plos One. 6: e21121. PMID 21754983 DOI: 10.1371/journal.pone.0021121  1
2011 Nagano Y, Fukushima T, Okemoto K, Tanaka K, Bowtell DD, Ronai Z, Reed JC, Matsuzawa S. Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress. Cell Cycle (Georgetown, Tex.). 10: 2592-602. PMID 21734459 DOI: 10.4161/cc.10.15.16912  1
2011 Bell D, Berchuck A, Birrer M, Chien J, Cramer DW, Dao F, Dhir R, Disaia P, Gabra H, Glenn P, Godwin AK, Gross J, Hartmann L, Huang M, Huntsman DG, ... ... Bowtell D, et al. Integrated genomic analyses of ovarian carcinoma Nature. 474: 609-615. PMID 21720365 DOI: 10.1038/nature10166  1
2011 Ledermann JA, Marth C, Carey MS, Birrer M, Bowtell DD, Kaye S, McNeish I, Oza A, Scambia G, Rustin G, Stehman FB, Gershenson D, Thomas G, Berns E, Casado A, et al. Role of molecular agents and targeted therapy in clinical trials for women with ovarian cancer. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society. 21: 763-70. PMID 21543938 DOI: 10.1097/IGC.0b013e31821b2669  1
2011 Nagle CM, Francis JE, Nelson AE, Zorbas H, Luxford K, de Fazio A, Fereday S, Bowtell DD, Green AC, Webb PM. Reducing time to diagnosis does not improve outcomes for women with symptomatic ovarian cancer: a report from the Australian Ovarian Cancer Study Group. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 2253-8. PMID 21537035 DOI: 10.1200/JCO.2010.32.2164  1
2011 Helland Ã…, Anglesio MS, George J, Cowin PA, Johnstone CN, House CM, Sheppard KE, Etemadmoghadam D, Melnyk N, Rustgi AK, Phillips WA, Johnsen H, Holm R, Kristensen GB, Birrer MJ, ... ... Bowtell DD, et al. Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers. Plos One. 6: e18064. PMID 21533284 DOI: 10.1371/journal.pone.0018064  1
2011 Emmanuel C, Gava N, Kennedy C, Balleine RL, Sharma R, Wain G, Brand A, Hogg R, Etemadmoghadam D, George J, Birrer MJ, Clarke CL, Chenevix-Trench G, Bowtell DD, et al. Comparison of expression profiles in ovarian epithelium in vivo and ovarian cancer identifies novel candidate genes involved in disease pathogenesis. Plos One. 6: e17617. PMID 21423607 DOI: 10.1371/journal.pone.0017617  1
2011 McConechy MK, Anglesio MS, Kalloger SE, Yang W, Senz J, Chow C, Heravi-Moussavi A, Morin GB, Mes-Masson AM, Carey MS, McAlpine JN, Kwon JS, Prentice LM, Boyd N, et al. Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas. The Journal of Pathology. 223: 567-73. PMID 21381030 DOI: 10.1002/path.2848  1
2011 Anglesio MS, George J, Kulbe H, Friedlander M, Rischin D, Lemech C, Power J, Coward J, Cowin PA, House CM, Chakravarty P, Gorringe KL, Campbell IG, Okamoto A, ... ... Bowtell DD, et al. IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2538-48. PMID 21343371 DOI: 10.1158/1078-0432.CCR-10-3314  1
2011 Zhang X, George J, Deb S, Degoutin JL, Takano EA, Fox SB, Bowtell DD, Harvey KF. The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene. Oncogene. 30: 2810-22. PMID 21317925 DOI: 10.1038/onc.2011.8  1
2011 Chan P, Möller A, Liu MC, Sceneay JE, Wong CS, Waddell N, Huang KT, Dobrovic A, Millar EK, O'Toole SA, McNeil CM, Sutherland RL, Bowtell DD, Fox SB. The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression. Breast Cancer Research : Bcr. 13: R19. PMID 21306611 DOI: 10.1186/bcr2828  1
2011 Bowtell DDL, Friedlander M, Quinn M, Mitchell G. A response to the forgotten fallopian tube Nature Reviews Cancer. 11: c2. DOI: 10.1038/nrc2946-c2  1
2010 Etemadmoghadam D, George J, Cowin PA, Cullinane C, Kansara M, Gorringe KL, Smyth GK, Bowtell DD. Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer. Plos One. 5: e15498. PMID 21103391 DOI: 10.1371/journal.pone.0015498  1
2010 Bowtell DD. The genesis and evolution of high-grade serous ovarian cancer. Nature Reviews. Cancer. 10: 803-8. PMID 20944665 DOI: 10.1038/nrc2946  1
2010 Wiegand KC, Shah SP, Al-Agha OM, Zhao Y, Tse K, Zeng T, Senz J, McConechy MK, Anglesio MS, Kalloger SE, Yang W, Heravi-Moussavi A, Giuliany R, Chow C, Fee J, ... ... Bowtell DD, et al. ARID1A mutations in endometriosis-associated ovarian carcinomas. The New England Journal of Medicine. 363: 1532-43. PMID 20942669 DOI: 10.1056/NEJMoa1008433  1
2010 Gorringe KL, George J, Anglesio MS, Ramakrishna M, Etemadmoghadam D, Cowin P, Sridhar A, Williams LH, Boyle SE, Yanaihara N, Okamoto A, Urashima M, Smyth GK, Campbell IG, Bowtell DD, et al. Copy number analysis identifies novel interactions between genomic loci in ovarian cancer. Plos One. 5. PMID 20844748 DOI: 10.1371/journal.pone.0011408  1
2010 Ahmed AA, Lu Z, Jennings NB, Etemadmoghadam D, Capalbo L, Jacamo RO, Barbosa-Morais N, Le XF, Vivas-Mejia P, Lopez-Berestein G, Grandjean G, Bartholomeusz G, Liao W, Andreeff M, ... Bowtell D, et al. SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer. Cancer Cell. 18: 109-21. PMID 20708153 DOI: 10.1016/j.ccr.2010.06.018  1
2010 Qi J, Nakayama K, Cardiff RD, Borowsky AD, Kaul K, Williams R, Krajewski S, Mercola D, Carpenter PM, Bowtell D, Ronai ZA. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell. 18: 23-38. PMID 20609350 DOI: 10.1016/j.ccr.2010.05.024  1
2010 Cowin PA, Anglesio M, Etemadmoghadam D, Bowtell DD. Profiling the cancer genome. Annual Review of Genomics and Human Genetics. 11: 133-59. PMID 20590430 DOI: 10.1146/annurev-genom-082509-141536  1
2010 Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabé RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, ... ... Bowtell DD, et al. International network of cancer genome projects. Nature. 464: 993-8. PMID 20393554 DOI: 10.1038/nature08987  1
2010 Ahmed AA, Etemadmoghadam D, Temple J, Lynch AG, Riad M, Sharma R, Stewart C, Fereday S, Caldas C, Defazio A, Bowtell D, Brenton JD. Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary. The Journal of Pathology. 221: 49-56. PMID 20229506 DOI: 10.1002/path.2696  1
2009 House CM, Möller A, Bowtell DD. Siah proteins: novel drug targets in the Ras and hypoxia pathways. Cancer Research. 69: 8835-8. PMID 19920190 DOI: 10.1158/0008-5472.CAN-09-1676  1
2009 Ooi CH, Ivanova T, Wu J, Lee M, Tan IB, Tao J, Ward L, Koo JH, Gopalakrishnan V, Zhu Y, Cheng LL, Lee J, Rha SY, Chung HC, Ganesan K, ... ... Bowtell D, et al. Oncogenic pathway combinations predict clinical prognosis in gastric cancer. Plos Genetics. 5: e1000676. PMID 19798449 DOI: 10.1371/journal.pgen.1000676  1
2009 Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell. 16: 115-25. PMID 19647222 DOI: 10.1016/j.ccr.2009.06.006  1
2009 Shah SP, Köbel M, Senz J, Morin RD, Clarke BA, Wiegand KC, Leung G, Zayed A, Mehl E, Kalloger SE, Sun M, Giuliany R, Yorida E, Jones S, Varhol R, ... ... Bowtell DD, et al. Mutation of FOXL2 in granulosa-cell tumors of the ovary. The New England Journal of Medicine. 360: 2719-29. PMID 19516027 DOI: 10.1056/NEJMoa0902542  1
2009 Etemadmoghadam D, deFazio A, Beroukhim R, Mermel C, George J, Getz G, Tothill R, Okamoto A, Raeder MB, Harnett P, Lade S, Akslen LA, Tinker AV, Locandro B, Alsop K, ... ... Bowtell D, et al. Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 1417-27. PMID 19193619 DOI: 10.1158/1078-0432.CCR-08-1564  1
2009 Calzado MA, de la Vega L, Möller A, Bowtell DD, Schmitz ML. An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nature Cell Biology. 11: 85-91. PMID 19043406 DOI: 10.1038/ncb1816  1
2009 Möller A, House CM, Wong CS, Scanlon DB, Liu MC, Ronai Z, Bowtell DD. Inhibition of Siah ubiquitin ligase function. Oncogene. 28: 289-96. PMID 18850011 DOI: 10.1038/onc.2008.382  1
2008 Anglesio MS, Arnold JM, George J, Tinker AV, Tothill R, Waddell N, Simms L, Locandro B, Fereday S, Traficante N, Russell P, Sharma R, Birrer MJ, deFazio A, ... ... Bowtell DD, et al. Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors. Molecular Cancer Research : McR. 6: 1678-90. PMID 19010816 DOI: 10.1158/1541-7786.MCR-08-0193  1
2008 Lose F, Duffy DL, Kay GF, Kedda MA, Spurdle AB. Skewed X chromosome inactivation and breast and ovarian cancer status: evidence for X-linked modifiers of BRCA1. Journal of the National Cancer Institute. 100: 1519-29. PMID 18957670 DOI: 10.1093/jnci/djn345  1
2008 Qi J, Nakayama K, Gaitonde S, Goydos JS, Krajewski S, Eroshkin A, Bar-Sagi D, Bowtell D, Ronai Z. The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proceedings of the National Academy of Sciences of the United States of America. 105: 16713-8. PMID 18946040 DOI: 10.1073/pnas.0804063105  1
2008 Tothill RW, Tinker AV, George J, Brown R, Fox SB, Lade S, Johnson DS, Trivett MK, Etemadmoghadam D, Locandro B, Traficante N, Fereday S, Hung JA, Chiew YE, Haviv I, ... ... Bowtell DD, et al. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 5198-208. PMID 18698038 DOI: 10.1158/1078-0432.CCR-08-0196  1
2008 Olsen CM, Nagle CM, Whiteman DC, Purdie DM, Green AC, Webb PM. Body size and risk of epithelial ovarian and related cancers: a population-based case-control study. International Journal of Cancer. Journal International Du Cancer. 123: 450-6. PMID 18449887 DOI: 10.1002/ijc.23509  1
2008 Ramus SJ, Vierkant RA, Johnatty SE, Pike MC, Van Den Berg DJ, Wu AH, Pearce CL, Menon U, Gentry-Maharaj A, Gayther SA, Dicioccio RA, McGuire V, Whittemore AS, Song H, Easton DF, et al. Consortium analysis of 7 candidate SNPs for ovarian cancer. International Journal of Cancer. Journal International Du Cancer. 123: 380-8. PMID 18431743 DOI: 10.1002/ijc.23448  1
2008 Frank B, Wiestler M, Kropp S, Hemminki K, Spurdle AB, Sutter C, Wappenschmidt B, Chen X, Beesley J, Hopper JL, Meindl A, Kiechle M, Slanger T, Bugert P, Schmutzler RK, ... ... Bowtell D, et al. Association of a common AKAP9 variant with breast cancer risk: A collaborative analysis Journal of the National Cancer Institute. 100: 437-442. PMID 18334708 DOI: 10.1093/jnci/djn037  1
2008 Yun S, Möller A, Chae SK, Hong WP, Bae YJ, Bowtell DD, Ryu SH, Suh PG. Siah proteins induce the epidermal growth factor-dependent degradation of phospholipase Cepsilon. The Journal of Biological Chemistry. 283: 1034-42. PMID 17998205 DOI: 10.1074/jbc.M705874200  1
2008 Merritt MA, Green AC, Nagle CM, Webb PM. Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer. International Journal of Cancer. Journal International Du Cancer. 122: 170-6. PMID 17721999 DOI: 10.1002/ijc.23017  1
2008 Bowtell D. Impact of gene technologies on personalised cancer therapy Cancer Forum. 32: 136-138.  1
2007 Beesley J, Jordan SJ, Spurdle AB, Song H, Ramus SJ, Kjaer SK, Hogdall E, DiCioccio RA, McGuire V, Whittemore AS, Gayther SA, Pharoah PD, Webb PM, Chenevix-Trench G, et al. Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 2557-65. PMID 18086758 DOI: 10.1158/1055-9965.EPI-07-0542  1
2007 Olsen CM, Bain CJ, Jordan SJ, Nagle CM, Green AC, Whiteman DC, Webb PM. Recreational physical activity and epithelial ovarian cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 2321-30. PMID 18006921 DOI: 10.1158/1055-9965.EPI-07-0566  1
2007 Krypuy M, Ahmed AA, Etemadmoghadam D, Hyland SJ, DeFazio A, Fox SB, Brenton JD, Bowtell DD, Dobrovic A. High resolution melting for mutation scanning of TP53 exons 5-8. Bmc Cancer. 7: 168. PMID 17764544 DOI: 10.1186/1471-2407-7-168  1
2006 Holloway AJ, Oshlack A, Diyagama DS, Bowtell DD, Smyth GK. Statistical analysis of an RNA titration series evaluates microarray precision and sensitivity on a whole-array basis. Bmc Bioinformatics. 7: 511. PMID 17118209 DOI: 10.1186/1471-2105-7-511  1
2006 Millward MJ, House C, Bowtell D, Webster L, Olver IN, Gore M, Copeman M, Lynch K, Yap A, Wang Y, Cohen PS, Zalcberg J. The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study. British Journal of Cancer. 95: 829-34. PMID 16969355 DOI: 10.1038/sj.bjc.6603331  1
2006 Holloway AJ, Diyagama DS, Opeskin K, Creaney J, Robinson BW, Lake RA, Bowtell DD. A molecular diagnostic test for distinguishing lung adenocarcinoma from malignant mesothelioma using cells collected from pleural effusions. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5129-35. PMID 16951230 DOI: 10.1158/1078-0432.CCR-06-1027  1
2006 Tinker AV, Boussioutas A, Bowtell DD. The challenges of gene expression microarrays for the study of human cancer. Cancer Cell. 9: 333-9. PMID 16697954 DOI: 10.1016/j.ccr.2006.05.001  1
2006 OzdaÄŸ H, Teschendorff AE, Ahmed AA, Hyland SJ, Blenkiron C, Bobrow L, Veerakumarasivam A, Burtt G, Subkhankulova T, Arends MJ, Collins VP, Bowtell D, Kouzarides T, Brenton JD, Caldas C. Differential expression of selected histone modifier genes in human solid cancers. Bmc Genomics. 7: 90. PMID 16638127 DOI: 10.1186/1471-2164-7-90  1
2006 House CM, Hancock NC, Möller A, Cromer BA, Fedorov V, Bowtell DD, Parker MW, Polekhina G. Elucidation of the substrate binding site of Siah ubiquitin ligase. Structure (London, England : 1993). 14: 695-701. PMID 16615911 DOI: 10.1016/j.str.2005.12.013  1
2006 Aggarwal A, Guo DL, Hoshida Y, Yuen ST, Chu KM, So S, Boussioutas A, Chen X, Bowtell D, Aburatani H, Leung SY, Tan P. Topological and functional discovery in a gene coexpression meta-network of gastric cancer. Cancer Research. 66: 232-41. PMID 16397236 DOI: 10.1158/0008-5472.CAN-05-2232  1
2005 du Bois A, Quinn M, Thigpen T, Vermorken J, Avall-Lundqvist E, Bookman M, Bowtell D, Brady M, Casado A, Cervantes A, Eisenhauer E, Friedlaender M, Fujiwara K, Grenman S, Guastalla JP, et al. 2004 consensus statements on the management of ovarian cancer: final document of the 3rd International Gynecologic Cancer Intergroup Ovarian Cancer Consensus Conference (GCIG OCCC 2004). Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 16: viii7-viii12. PMID 16239238 DOI: 10.1093/annonc/mdi961  1
2005 Stuart G, Avall-Lundqvist E, du Bois A, Bookman M, Bowtell D, Brady M, Casado A, Cervantes A, Eisenhauer E, Friedlaender M, Fujiwara K, Grenman S, Guastalla JP, Harper P, Hogberg T, et al. 3rd International Ovarian Cancer Consensus Conference: outstanding issues for future consideration. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 16: viii36-viii38. PMID 16239235 DOI: 10.1093/annonc/mdi965  1
2005 Quinn M, Pfisterer J, Avall-Lundqvist E, Bookman M, Bowtell D, Casado A, Cervantes A, Grenman S, Harper P, Oza A, Pecorelli S, Pujade-Lauraine E, Trimble E, Vasey P, Wagner U, et al. Integration of new or experimental treatment options and new approaches to clinical trials. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 16: viii30-viii35. PMID 16239234 DOI: 10.1093/annonc/mdi964  1
2005 Liu T, Bohlken A, Kuljaca S, Lee M, Nguyen T, Smith S, Cheung B, Norris MD, Haber M, Holloway AJ, Bowtell DD, Marshall GM. The retinoid anticancer signal: mechanisms of target gene regulation. British Journal of Cancer. 93: 310-8. PMID 16012519 DOI: 10.1038/sj.bjc.6602700  1
2005 Tothill RW, Kowalczyk A, Rischin D, Bousioutas A, Haviv I, van Laar RK, Waring PM, Zalcberg J, Ward R, Biankin AV, Sutherland RL, Henshall SM, Fong K, Pollack JR, Bowtell DD, et al. An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin. Cancer Research. 65: 4031-40. PMID 15899792 DOI: 10.1158/0008-5472.CAN-04-3617  1
2005 Peart MJ, Smyth GK, van Laar RK, Bowtell DD, Richon VM, Marks PA, Holloway AJ, Johnstone RW. Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 102: 3697-702. PMID 15738394 DOI: 10.1073/pnas.0500369102  1
2005 Crowley MR, Bowtell D, Serra R. TGF-beta, c-Cbl, and PDGFR-alpha the in mammary stroma. Developmental Biology. 279: 58-72. PMID 15708558 DOI: 10.1016/j.ydbio.2004.11.034  1
2005 Gorringe KL, Boussioutas A, Bowtell DD. Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization. Genes, Chromosomes & Cancer. 42: 247-59. PMID 15611932 DOI: 10.1002/gcc.20136  1
2004 Thomas DM, Johnson SA, Sims NA, Trivett MK, Slavin JL, Rubin BP, Waring P, McArthur GA, Walkley CR, Holloway AJ, Diyagama D, Grim JE, Clurman BE, Bowtell DD, Lee JS, et al. Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. The Journal of Cell Biology. 167: 925-34. PMID 15583032 DOI: 10.1083/jcb.200409187  1
2004 Molero JC, Jensen TE, Withers PC, Couzens M, Herzog H, Thien CB, Langdon WY, Walder K, Murphy MA, Bowtell DD, James DE, Cooney GJ. c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action. The Journal of Clinical Investigation. 114: 1326-33. PMID 15520865 DOI: 10.1172/JCI21480  1
2004 Thomas DM, Fleming NI, Holloway AJ, Bowtell DD. Molecular medicine: a clinician's primer on microarrays. Internal Medicine Journal. 34: 565-9. PMID 15482270 DOI: 10.1111/j.1445-5994.2004.00680.x  1
2004 Habelhah H, Laine A, Erdjument-Bromage H, Tempst P, Gershwin ME, Bowtell DD, Ronai Z. Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah. The Journal of Biological Chemistry. 279: 53782-8. PMID 15466852 DOI: 10.1074/jbc.M410315200  1
2004 Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, Kadoya T, Erdjument-Bromage H, Tempst P, Frappell PB, Bowtell DD, Ronai Z. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1α abundance, and modulates physiological responses to hypoxia Cell. 117: 941-952. PMID 15210114 DOI: 10.1016/j.cell.2004.06.001  1
2004 Frew IJ, Sims NA, Quinn JM, Walkley CR, Purton LE, Bowtell DD, Gillespie MT. Osteopenia in Siah1a mutant mice. The Journal of Biological Chemistry. 279: 29583-8. PMID 15123657 DOI: 10.1074/jbc.M312755200  1
2004 Quinn LM, Dickins RA, Coombe M, Hime GR, Bowtell DD, Richardson H. Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation. Development (Cambridge, England). 131: 1411-23. PMID 14993190 DOI: 10.1242/dev.01019  1
2003 Frew IJ, Hammond VE, Dickins RA, Quinn JMW, Walkley CR, Sims NA, Schnall R, Della NG, Holloway AJ, Digby MR, Janes PW, Tarlinton DM, Purton LE, Gillespie MT, Bowtell DDL. Generation and Analysis of Siah2 Mutant Mice Molecular and Cellular Biology. 23: 9150-9161. PMID 14645526 DOI: 10.1128/MCB.23.24.9150-9161.2003  1
2003 Duan L, Miura Y, Dimri M, Majumder B, Dodge IL, Reddi AL, Ghosh A, Fernandes N, Zhou P, Mullane-Robinson K, Rao N, Donoghue S, Rogers RA, Bowtell D, Naramura M, et al. Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis Journal of Biological Chemistry. 278: 28950-28960. PMID 12754251 DOI: 10.1074/jbc.M304474200  1
2003 Boussioutas A, Li H, Liu J, Waring P, Lade S, Holloway AJ, Taupin D, Gorringe K, Haviv I, Desmond PV, Bowtell DDL. Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer Cancer Research. 63: 2569-2577. PMID 12750281  1
2003 Caveggion E, Continolo S, Pixley FJ, Stanley ER, Bowtell DDL, Lowell CA, Berton G. Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement Journal of Cellular Physiology. 195: 276-289. PMID 12652654 DOI: 10.1002/jcp.10236  1
2003 House CM, Frew IJ, Huang HL, Wiche G, Traficante N, Nice E, Catimel B, Bowtell DD. A binding motif for Siah ubiquitin ligase. Proceedings of the National Academy of Sciences of the United States of America. 100: 3101-6. PMID 12626763 DOI: 10.1073/pnas.0534783100  1
2003 Thien CBF, Scaife RM, Papadimitriou JM, Murphy MA, Bowtell DDL, Langdon WY. A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase Journal of Experimental Medicine. 197: 503-513. PMID 12591907 DOI: 10.1084/jem.20021498  1
2003 Bowtell D. Molecular prognosis of epithelial ovarian cancer: Observations from current literature Cancer Forum. 27: 157-159.  1
2002 Holloway AJ, Van Laar RK, Tothill RW, Bowtell DDL. Options available - From start to finish - For obtaining data from DNA microarrays II Nature Genetics. 32: 481-489. PMID 12454642  1
2002 Frew IJ, Dickins RA, Cuddihy AR, Del Rosario M, Reinhard C, O'Connell MJ, Bowtell DD. Normal p53 function in primary cells deficient for Siah genes. Molecular and Cellular Biology. 22: 8155-64. PMID 12417719 DOI: 10.1128/MCB.22.23.8155-8164.2002  1
2002 Habelhah H, Frew IJ, Laine A, Janes PW, Relaix F, Sassoon D, Bowtell DD, Ronai Z. Stress-induced decrease in TRAF2 stability is mediated by Siah2. The Embo Journal. 21: 5756-65. PMID 12411493 DOI: 10.1093/emboj/cdf576  1
2002 Kong CF, Bowtell D. Genomewide gene expression analysis using cDNA microarrays Methods in Molecular Medicine. 68: 195-204. PMID 11901503  1
2002 Dickins RA, Frew IJ, House CM, O'Bryan MK, Holloway AJ, Haviv I, Traficante N, de Kretser DM, Bowtell DD. The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice. Molecular and Cellular Biology. 22: 2294-303. PMID 11884614 DOI: 10.1128/MCB.22.7.2294-2303.2002  1
2002 Polekhina G, House CM, Traficante N, Mackay JP, Relaix F, Sassoon DA, Parker MW, Bowtell DD. Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. Nature Structural Biology. 9: 68-75. PMID 11742346 DOI: 10.1038/nsb743  1
2001 Blesofsky WA, Mowen K, Arduini RM, Baker DP, Murphy MA, Bowtell DDL, David M. Regulation of STAT protein synthesis by c-Cbl Oncogene. 20: 7326-7333. PMID 11704862 DOI: 10.1038/sj.onc.1204919  1
2001 Sourisseau T, Desbois C, Debure L, Bowtell DDL, Cato ACB, Schneikert J, Moyse E, Miche D. Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis Journal of Cell Science. 114: 1409-1416. PMID 11257006  1
2001 Sanjay A, Houghton A, Neff L, DiDomenico E, Bardelay C, Antoine E, Levy J, Gailit J, Bowtell D, Horne WC, Baron R. Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. The Journal of Cell Biology. 152: 181-95. PMID 11149930 DOI: 10.1083/jcb.152.1.181  1
2000 Robertson H, Hime GR, Lada H, Bowtell DD. A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo. Oncogene. 19: 3299-308. PMID 10918586 DOI: 10.1038/sj.onc.1203624  1
2000 Relaix F, Wei Xj, Li W, Pan J, Lin Y, Bowtell DD, Sassoon DA, Wu X. Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 97: 2105-10. PMID 10681424 DOI: 10.1073/pnas.040378897  1
2000 Andoniou CE, Lill NL, Thien CB, Lupher ML, Ota S, Bowtell DDL, Scaife RM, Langdon WY, Band H. The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation Molecular and Cellular Biology. 20: 851-867. PMID 10629042 DOI: 10.1128/MCB.20.3.851-867.2000  1
1999 Lee PSW, Wang Y, Dominguez MG, Yeung YG, Murphy MA, Bowtell DDL, Stanley ER. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation Embo Journal. 18: 3616-3628. PMID 10393178 DOI: 10.1093/emboj/18.13.3616  1
1999 Thien CBF, Bowtell DDL, Langdon WY. Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-CBL-deficient thymocytes Journal of Immunology. 162: 7133-7139. PMID 10358158  1
1999 Bowtell DDL. Options available - From start to finish - For obtaining expression data by microarray Nature Genetics. 21: 25-32. PMID 9915497 DOI: 10.1038/4455  1
1999 Chuang Fong Kong, Bowtell DDL. Microarray technology for gene expression analysis Today's Life Science. 11: 24-30.  1
1998 Murphy MA, Schnall RG, Venter DJ, Barnett L, Bertoncello I, Thien CBF, Langdon WY, Bowtell DDL. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl- deficient mice Molecular and Cellular Biology. 18: 4872-4882. PMID 9671496  1
1998 Kim JH, Shirouzu M, Kataoka T, Bowtell D, Yokoyama S. Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless 1 (mSos1) Oncogene. 16: 2597-2607. PMID 9632136  1
1997 Robertson H, Langdon WY, Thien CBF, Bowtell DDL. A c-cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components Biochemical and Biophysical Research Communications. 240: 46-50. PMID 9367879 DOI: 10.1006/bbrc.1997.7608  1
1997 Kilian A, Bowtell DD, Abud HE, Hime GR, Venter DJ, Keese PK, Duncan EL, Reddel RR, Jefferson RA. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Human Molecular Genetics. 6: 2011-9. PMID 9328464 DOI: 10.1093/hmg/6.12.2011  1
1997 Koshiba S, Kigawa T, Kim JH, Shirouzu M, Bowtell D, Yokoyama S. The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1) Journal of Molecular Biology. 269: 579-591. PMID 9217262 DOI: 10.1006/jmbi.1997.1041  1
1997 Hime GR, Dhungat MP, Ng A, Bowtell DD. D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites. Oncogene. 14: 2709-19. PMID 9178769 DOI: 10.1038/sj.onc.1201223  1
1997 Holloway AJ, Della NG, Fletcher CF, Largespada DA, Copeland NG, Jenkins NA, Bowtell DDL. Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene Seven-in-absentia Genomics. 41: 160-168. PMID 9143490 DOI: 10.1006/geno.1997.4642  1
1997 Mack HG, Beck F, Bowtell DDL. A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64, a zinc finger encoding gene which maps to the distal end of mouse chromosome 2 Gene. 185: 11-17. PMID 9034307 DOI: 10.1016/S0378-1119(96)00607-5  1
1997 Wang DZM, Hammond VE, Abud HE, Bertoncello I, McAvoy JW, Bowtell DDL. Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for sos1 in EGFR signaling and development Genes and Development. 11: 309-320. PMID 9030684  1
1996 Hu Y, Bowtell DDL. Sos1 rapidly associates with Grb2 and is hypophosphorylated when complexed with the EGF receptor after EGF stimulation Oncogene. 12: 1865-1872. PMID 8649846  1
1996 Bowtell DDL. The role of Son of sevenless guanine nucleotide exchange factors in linking cell surface receptors with ras Current Opinion in Endocrinology and Diabetes. 3: 388-396.  1
1995 Della NG, Hu Y, Holloway AJ, Wang D, Bowtell DDL. A combined genetic and biochemical approach to mammalian signal transduction Australian and New Zealand Journal of Medicine. 25: 845-851. PMID 8770362  1
1995 Della NG, Bowtell DDL, Beck F. Expression of Siah-2, a vertebrate homologue of Drosophila sina, in germ cells of the mouse ovary and testis Cell & Tissue Research. 279: 411-419. PMID 7895278 DOI: 10.1007/BF00318499  1
1995 Sakaue M, Bowtell D, Kasuga M. A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways Molecular and Cellular Biology. 15: 379-388. PMID 7799946  1
1995 Bowtell DDL, Langdon WY. The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation Oncogene. 11: 1561-1567. PMID 7478580  1
1994 Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T. Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway Embo Journal. 13: 764-773. PMID 8112292  1
1994 Welham MJ, Duronio V, Leslie KB, Bowtell D, Schrader JW. Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation Journal of Biological Chemistry. 269: 21165-21176. PMID 8063737  1
1994 Saxton TM, Van Oostveen I, Bowtell D, Aebersold R, Gold MR. B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein Journal of Immunology. 153: 623-636. PMID 8021500  1
1994 Lioubin MN, Myles GM, Carlberg K, Bowtell D, Rohrschneider LR. Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells Molecular and Cellular Biology. 14: 5682-5691. PMID 7520523  1
1993 Della NG, Senior PV, Bowtell DDL. Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina) Development. 117: 1333-1343. PMID 8404535  1
1993 Webb GC, Jenkins NA, Largaespada DA, Copeland NG, Fernandez CS, Bowtell DDL. Mammalian Homologues of the Drosophila Son of sevenless Gene Map to Murine Chromosomes 17 and 12 and to Human Chromosomes 2 and 14, Respectively Genomics. 18: 14-19. PMID 8276400 DOI: 10.1006/geno.1993.1421  1
1993 Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 Nature. 362: 83-85.  1
1992 Bowtell D, Fu P, Simon M, Senior P. Identification of murine homologues of the Drosophila son of sevenless gene: Potential activators of ras Proceedings of the National Academy of Sciences of the United States of America. 89: 6511-6515. PMID 1631150 DOI: 10.1073/pnas.89.14.6511  1
1991 Simon MA, Bowtell DD, Dodson GS, Laverty TR, Rubin GM. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell. 67: 701-16. PMID 1934068  1
1991 Bowtell DD, Lila T, Michael WM, Hackett D, Rubin GM. Analysis of the enhancer element that controls expression of sevenless in the developing Drosophila eye. Proceedings of the National Academy of Sciences of the United States of America. 88: 6853-7. PMID 1907377 DOI: 10.1073/pnas.88.15.6853  1
1990 Michael WM, Bowtell DD, Rubin GM. Comparison of the sevenless genes of Drosophila virilis and Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 87: 5351-3. PMID 2115169 DOI: 10.1073/pnas.87.14.5351  1
1989 Bowtell DD, Simon MA, Rubin GM. Ommatidia in the developing Drosophila eye require and can respond to sevenless for only a restricted period. Cell. 56: 931-6. PMID 2924353 DOI: 10.1016/0092-8674(89)90626-0  1
1989 Simon MA, Bowtell DD, Rubin GM. Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 86: 8333-7. PMID 2682647  1
1989 Bowtell DD, Kimmel BE, Simon MA, Rubin GM. Regulation of the complex pattern of sevenless expression in the developing Drosophila eye. Proceedings of the National Academy of Sciences of the United States of America. 86: 6245-9. PMID 2503829  1
1988 Bowtell DDL, Cory S, Johnson GR, Gonda TJ. Comparison of expression in hemopoietic cells by retroviral vectors carrying two genes Journal of Virology. 62: 2464-2473. PMID 3373574  1
1988 Bowtell DD, Simon MA, Rubin GM. Nucleotide sequence and structure of the sevenless gene of Drosophila melanogaster. Genes & Development. 2: 620-34. PMID 3138161  1
1987 Bowtell DD, Johnson GR, Kelso A, Cory S. Expression of genes transferred to haemopoietic stem cells by recombinant retroviruses Molecular Biology & Medicine. 4: 229-250. PMID 3670048  1
1987 Cory S, Bernard O, Bowtell D, Schrader S, Schrader JW. Murine c-myc retroviruses alter the growth requirements of myeloid cell lines Oncogene Research. 1: 61-76. PMID 3329710  1
1987 Tomlinson A, Bowtell DD, Hafen E, Rubin GM. Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila. Cell. 51: 143-50. PMID 3115593 DOI: 10.1016/0092-8674(87)90019-5  1
1987 Bowtell DDL. Rapid isolation of eukaryotic DNA Analytical Biochemistry. 162: 463-465. PMID 3037944 DOI: 10.1016/0003-2697(87)90421-0  1
1986 Bowtell DD, Saint RB, Rickard MD, Mitchell GF. Immunochemical analysis of Taenia taeniaeformis antigens expressed in Escherichia coli. Parasitology. 93: 599-610. PMID 3540818  1
1984 Lightowlers MW, Mitchell GF, Bowtell DDL, Anders RF, Rickard MD. Immunization against Taenia taeniaeformis in mice: Studies on the characterization of antigens from oncospheres International Journal For Parasitology. 14: 321-333. PMID 6469450 DOI: 10.1016/0020-7519(84)90084-5  1
1983 Whithear KG, Bowtell DD, Ghiocas E, Hughes KL. Evaluation and use of a micro-broth dilution procedure for testing sensitivity of fermentative avian mycoplasmas to antibiotics Avian Diseases. 27: 937-949. PMID 6651705  1
1983 Bowtell DDL, Mitchell GF, Anders RF, Lightowlers MW, Rickard MD. Taenia taeniaeformis: Immunoprecipitation analysis of the protein antigens of oncospheres and larvae Experimental Parasitology. 56: 416-427. PMID 6641898 DOI: 10.1016/0014-4894(83)90087-5  1
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