Raymond A. Pagliarini, Ph.D. - Publications

Affiliations: 
Novartis, Basel, Basel-Stadt, France 

21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Levell JR, Caferro T, Chenail G, Dix I, Dooley J, Firestone B, Fortin PD, Giraldes J, Gould T, Growney JD, Jones MD, Kulathila R, Lin F, Liu G, Mueller A, ... ... Pagliarini R, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. Acs Medicinal Chemistry Letters. 8: 151-156. PMID 28197303 DOI: 10.1021/Acsmedchemlett.6B00334  0.4
2017 Xie X, Baird D, Bowen K, Capka V, Chen J, Chenail G, Cho Y, Dooley J, Farsidjani A, Fortin P, Kohls D, Kulathila R, Lin F, McKay D, Rodrigues L, ... ... Pagliarini RA, et al. Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure (London, England : 1993). PMID 28132785 DOI: 10.1016/J.Str.2016.12.017  0.4
2016 Mounir Z, Korn JM, Westerling T, Lin F, Kirby CA, Schirle M, McAllister G, Hoffman G, Ramadan N, Hartung A, Feng Y, Kipp DR, Quinn C, Fodor M, Baird J, ... ... Pagliarini RA, et al. ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the androgen receptor. Elife. 5. PMID 27183006 DOI: 10.7554/Elife.13964  1
2015 Pagliarini R, Shao W, Sellers WR. Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure. Embo Reports. 16: 280-96. PMID 25680965 DOI: 10.15252/Embr.201439949  1
2015 Hassan AQ, Kirby CA, Zhou W, Schuhmann T, Kityk R, Kipp DR, Baird J, Chen J, Chen Y, Chung F, Hoepfner D, Movva NR, Pagliarini R, Petersen F, Quinn C, et al. The novolactone natural product disrupts the allosteric regulation of Hsp70. Chemistry & Biology. 22: 87-97. PMID 25544045 DOI: 10.1016/J.Chembiol.2014.11.007  1
2015 Mounir Z, Lin F, Lin VG, Korn JM, Yu Y, Valdez R, Aina OH, Buchwalter G, Jaffe AB, Korpal M, Zhu P, Brown M, Cardiff RD, Rocnik JL, Yang Y, ... Pagliarini R, et al. TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation. Oncogene. 34: 3815-25. PMID 25263440 DOI: 10.1038/Onc.2014.308  1
2014 Chen Y, Chen J, Yu J, Yang G, Temple E, Harbinski F, Gao H, Wilson C, Pagliarini R, Zhou W. Identification of mixed lineage leukemia 1(MLL1) protein as a coactivator of heat shock factor 1(HSF1) protein in response to heat shock protein 90 (HSP90) inhibition. The Journal of Biological Chemistry. 289: 18914-27. PMID 24831003 DOI: 10.1074/Jbc.M114.574053  1
2014 Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, ... ... Pagliarini R, et al. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Research. 74: 3317-31. PMID 24755473 DOI: 10.1158/0008-5472.Can-14-0772-T  1
2014 Pop MS, Stransky N, Garvie CW, Theurillat JP, Hartman EC, Lewis TA, Zhong C, Culyba EK, Lin F, Daniels DS, Pagliarini R, Ronco L, Koehler AN, Garraway LA. A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein. Molecular Cancer Therapeutics. 13: 1492-502. PMID 24737027 DOI: 10.1158/1535-7163.Mct-13-0689  1
2014 Grassian AR, Pagliarini R, Chiang DY. Mutations of isocitrate dehydrogenase 1 and 2 in intrahepatic cholangiocarcinoma. Current Opinion in Gastroenterology. 30: 295-302. PMID 24569570 DOI: 10.1097/Mog.0000000000000050  1
2013 Chen J, Chung F, Yang G, Pu M, Gao H, Jiang W, Yin H, Capka V, Kasibhatla S, Laffitte B, Jaeger S, Pagliarini R, Chen Y, Zhou W. Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth. Oncotarget. 4: 2502-11. PMID 24318446 DOI: 10.18632/Oncotarget.1540  1
2013 Chen Y, Chen J, Loo A, Jaeger S, Bagdasarian L, Yu J, Chung F, Korn J, Ruddy D, Guo R, McLaughlin ME, Feng F, Zhu P, Stegmeier F, Pagliarini R, et al. Targeting HSF1 sensitizes cancer cells to HSP90 inhibition. Oncotarget. 4: 816-29. PMID 23615731 DOI: 10.18632/Oncotarget.991  1
2012 Grassian AR, Lin F, Barrett R, Liu Y, Jiang W, Korpal M, Astley H, Gitterman D, Henley T, Howes R, Levell J, Korn JM, Pagliarini R. Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT). The Journal of Biological Chemistry. 287: 42180-94. PMID 23038259 DOI: 10.1074/Jbc.M112.417832  1
2010 Halilovic E, She QB, Ye Q, Pagliarini R, Sellers WR, Solit DB, Rosen N. PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling. Cancer Research. 70: 6804-14. PMID 20699365 DOI: 10.1158/0008-5472.Can-10-0409  1
2009 Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B, et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science (New York, N.Y.). 325: 1555-9. PMID 19661383 DOI: 10.1126/Science.1174229  1
2009 Sur S, Pagliarini R, Bunz F, Rago C, Diaz LA, Kinzler KW, Vogelstein B, Papadopoulos N. A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. Proceedings of the National Academy of Sciences of the United States of America. 106: 3964-9. PMID 19225112 DOI: 10.1073/Pnas.0813333106  1
2007 Srivastava A, Pastor-Pareja JC, Igaki T, Pagliarini R, Xu T. Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion. Proceedings of the National Academy of Sciences of the United States of America. 104: 2721-6. PMID 17301221 DOI: 10.1073/Pnas.0611666104  1
2006 Igaki T, Pagliarini RA, Xu T. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Current Biology : Cb. 16: 1139-46. PMID 16753569 DOI: 10.1016/J.Cub.2006.04.042  1
2006 Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, et al. The colorectal microRNAome. Proceedings of the National Academy of Sciences of the United States of America. 103: 3687-92. PMID 16505370 DOI: 10.1073/Pnas.0511155103  1
2003 Pagliarini RA, Xu T. A genetic screen in Drosophila for metastatic behavior. Science (New York, N.Y.). 302: 1227-31. PMID 14551319 DOI: 10.1126/science.1088474  1
2003 Pagliarini RA, Quiñones AT, Xu T. Analyzing the function of tumor suppressor genes using a Drosophila model. Methods in Molecular Biology (Clifton, N.J.). 223: 349-82. PMID 12777740 DOI: 10.1385/1-59259-329-1:349  1
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