| Year |
Citation |
Score |
| 2022 |
Basole CP, Nguyen RK, Lamothe K, Billis P, Fujiwara M, Vang AG, Clark RB, Epstein PM, Brocke S. Treatment of Experimental Autoimmune Encephalomyelitis with an Inhibitor of Phosphodiesterase-8 (PDE8). Cells. 11. PMID 35203312 DOI: 10.3390/cells11040660 |
0.771 |
|
| 2021 |
Epstein PM, Basole C, Brocke S. The Role of PDE8 in T Cell Recruitment and Function in Inflammation. Frontiers in Cell and Developmental Biology. 9: 636778. PMID 33937235 DOI: 10.3389/fcell.2021.636778 |
0.617 |
|
| 2019 |
Suarez-Ramirez JE, Chandiran K, Brocke S, Cauley LS. Immunity to Respiratory Infection Is Reinforced Through Early Proliferation of Lymphoid T Cells and Prompt Arrival of Effector CD8 T Cells in the Lungs. Frontiers in Immunology. 10: 1370. PMID 31258537 DOI: 10.3389/Fimmu.2019.01370 |
0.588 |
|
| 2017 |
Basole CP, Nguyen RK, Lamothe K, Vang A, Clark R, Baillie GS, Epstein PM, Brocke S. PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cellular Signalling. PMID 28851628 DOI: 10.1016/J.Cellsig.2017.08.007 |
0.796 |
|
| 2016 |
Vang AG, Basole C, Dong H, Nguyen RK, Housley W, Guernsey L, Adami AJ, Thrall RS, Clark RB, Epstein PM, Brocke S. Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation. Frontiers in Pharmacology. 7: 259. PMID 27601994 DOI: 10.3389/Fphar.2016.00259 |
0.805 |
|
| 2015 |
Dong H, Claffey KP, Brocke S, Epstein PM. Inhibition of breast cancer cell migration by activation of cAMP signaling. Breast Cancer Research and Treatment. 152: 17-28. PMID 26022351 DOI: 10.1007/S10549-015-3445-9 |
0.322 |
|
| 2014 |
Schubert C, Guttek K, Grüngreiff K, Thielitz A, Bühling F, Reinhold A, Brocke S, Reinhold D. Oral zinc aspartate treats experimental autoimmune encephalomyelitis. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 27: 1249-62. PMID 25146336 DOI: 10.1007/S10534-014-9786-8 |
0.438 |
|
| 2014 |
Schubert C, Guttek K, Grüngreiff K, Thielitz A, Bühling F, Reinhold A, Brocke S, Reinhold D. Oral zinc aspartate treats experimental autoimmune encephalomyelitis Biometals. DOI: 10.1007/s10534-014-9786-8 |
0.329 |
|
| 2013 |
Vang AG, Housley W, Dong H, Basole C, Ben-Sasson SZ, Kream BE, Epstein PM, Clark RB, Brocke S. Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac. The Biochemical Journal. 456: 463-73. PMID 24007532 DOI: 10.1042/Bj20130064 |
0.799 |
|
| 2012 |
Stoye D, Schubert C, Goihl A, Guttek K, Reinhold A, Brocke S, Grüngreiff K, Reinhold D. Zinc aspartate suppresses T cell activation in vitro and relapsing experimental autoimmune encephalomyelitis in SJL/J mice Biometals. 25: 529-539. PMID 22350510 DOI: 10.1007/S10534-012-9532-Z |
0.55 |
|
| 2011 |
Housley WJ, Adams CO, Vang AG, Brocke S, Nichols FC, LaCombe M, Rajan TV, Clark RB. Peroxisome proliferator-activated receptor gamma is required for CD4+ T cell-mediated lymphopenia-associated autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 187: 4161-9. PMID 21908737 DOI: 10.4049/Jimmunol.1101731 |
0.793 |
|
| 2011 |
Biton A, Ansorge S, Bank U, Täger M, Reinhold D, Brocke S. Divergent actions by inhibitors of DP IV and APN family enzymes on CD4+ Teff cell motility and functions. Immunobiology. 216: 1295-301. PMID 21802166 DOI: 10.1016/J.Imbio.2011.07.001 |
0.626 |
|
| 2011 |
Bhowmick S, Clark RB, Brocke S, Cone RE. Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase. International Immunology. 23: 119-28. PMID 21273399 DOI: 10.1093/Intimm/Dxq461 |
0.54 |
|
| 2011 |
Reinhold D, Bank U, Entz D, Goihl A, Stoye D, Wrenger S, Brocke S, Thielitz A, Stefin S, Nordhoff K, Heimburg A, Täger M, Ansorge S. PETIR-001, a dual inhibitor of dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN), ameliorates experimental autoimmune encephalomyelitis in SJL/J mice. Biological Chemistry. 392: 233-7. PMID 21194377 DOI: 10.1515/Bc.2011.024 |
0.48 |
|
| 2010 |
Vang AG, Ben-Sasson SZ, Dong H, Kream B, DeNinno MP, Claffey MM, Housley W, Clark RB, Epstein PM, Brocke S. PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. Plos One. 5: e12011. PMID 20711499 DOI: 10.1371/Journal.Pone.0012011 |
0.789 |
|
| 2009 |
Reinhold D, Goihl A, Wrenger S, Reinhold A, Kühlmann UC, Faust J, Neubert K, Thielitz A, Brocke S, Täger M, Ansorge S, Bank U. Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: Investigations in DP IV/CD26-knockout mice Clinical Chemistry and Laboratory Medicine. 47: 268-274. PMID 19676138 DOI: 10.1515/Cclm.2009.062 |
0.502 |
|
| 2008 |
Kobayashi N, Kiptoo P, Kobayashi H, Ridwan R, Brocke S, Siahaan TJ. Prophylactic and therapeutic suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor. Clinical Immunology (Orlando, Fla.). 129: 69-79. PMID 18676182 DOI: 10.1016/J.Clim.2008.06.002 |
0.377 |
|
| 2008 |
Reinhold D, Bank U, Täger M, Ansorge S, Wrenger S, Thielitz A, Lendeckel U, Faust J, Neubert K, Brocke S. DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: Implications for experimental encephalomyelitis and multiple sclerosis Frontiers in Bioscience. 13: 2356-2363. PMID 17981717 DOI: 10.2741/2849 |
0.615 |
|
| 2007 |
Waiczies S, Bendix I, Prozorovski T, Ratner M, Nazarenko I, Pfueller CF, Brandt AU, Herz J, Brocke S, Ullrich O, Zipp F. Geranylgeranylation but not GTP loading determines rho migratory function in T cells Journal of Immunology. 179: 6024-6032. PMID 17947676 DOI: 10.4049/Jimmunol.179.9.6024 |
0.588 |
|
| 2007 |
Reinhold D, Biton A, Goihl A, Pieper S, Lendeckel U, Faust J, Neubert K, Bank U, Täger M, Ansorge S, Brocke S. Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses Annals of the New York Academy of Sciences. 1110: 402-409. PMID 17911455 DOI: 10.1196/Annals.1423.042 |
0.571 |
|
| 2007 |
Preller V, Gerber A, Wrenger S, Togni M, Marguet D, Tadje J, Lendeckel U, Röcken C, Faust J, Neubert K, Schraven B, Martin R, Ansorge S, Brocke S, Reinhold D. TGF-β1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26 Journal of Immunology. 178: 4632-4640. PMID 17372022 DOI: 10.4049/Jimmunol.178.7.4632 |
0.52 |
|
| 2006 |
Reinhold D, Biton A, Pieper S, Lendeckel U, Faust J, Neubert K, Bank U, Täger M, Ansorge S, Brocke S. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation International Immunopharmacology. 6: 1935-1942. PMID 17161346 DOI: 10.1016/J.Intimp.2006.07.023 |
0.601 |
|
| 2006 |
Preller V, Gerber A, Togni M, Wrenger S, Schraven B, Röcken C, Marguet D, Ansorge S, Brocke S, Reinhold D. CD26/DP IV in T cell activation and autoimmunity. Advances in Experimental Medicine and Biology. 575: 187-93. PMID 16700522 DOI: 10.1007/0-387-32824-6_20 |
0.482 |
|
| 2006 |
Biton A, Bank U, Täger M, Ansorge S, Reinhold D, Lendecke U, Brocke S. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation Advances in Experimental Medicine and Biology.. 575: 177-186. PMID 16700521 DOI: 10.1007/0-387-32824-6_19 |
0.502 |
|
| 2006 |
Dong H, Osmanova V, Epstein PM, Brocke S. Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes. Biochemical and Biophysical Research Communications. 345: 713-9. PMID 16696947 DOI: 10.1016/J.Bbrc.2006.04.143 |
0.421 |
|
| 2005 |
Aktas O, Smorodchenko A, Brocke S, Infante-Duarte C, Schulze Topphoff U, Vogt J, Prozorovski T, Meier S, Osmanova V, Pohl E, Bechmann I, Nitsch R, Zipp F. Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL. Neuron. 46: 421-32. PMID 15882642 DOI: 10.1016/J.Neuron.2005.03.018 |
0.432 |
|
| 2005 |
Aktas O, Smorodchenko A, Brocke S, Infante-Duarte C, Schulze Topphoff U, Vogt J, Prozorovski T, Meier S, Osmanova V, Pohl E, Bechmann I, Nitsch R, Zipp F. Neuronale Schädigung bei autoimmuner Demyelinisierung: TRAIL-vermittelte T-Zell-abhängige Apoptose von Neuronen im Mausmodell der Multiplen Sklerose Aktuelle Neurologie. 32. DOI: 10.1055/S-2005-919258 |
0.398 |
|
| 2005 |
Reinhold D, Kähne T, Steinbrecher A, Gerber A, Preller V, Gornickel B, Wrenger S, Ansorge S, Brocke S. The role of dipeptidyl peptidase IV (DP IV, CD26) in T cell activation and multiple sclerosis Signal Transduction. 5: 258-265. DOI: 10.1002/Sita.200500069 |
0.623 |
|
| 2004 |
Aktas O, Prozorovski T, Smorodchenko A, Savaskan NE, Lauster R, Kloetzel PM, Infante-Duarte C, Brocke S, Zipp F. Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 173: 5794-800. PMID 15494532 DOI: 10.4049/Jimmunol.173.9.5794 |
0.531 |
|
| 2004 |
Franitza S, Grabovsky V, Wald O, Weiss I, Beider K, Dagan M, Darash-Yahana M, Nagler A, Brocke S, Galun E, Alon R, Peled A. Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells. European Journal of Immunology. 34: 1333-41. PMID 15114666 DOI: 10.1002/Eji.200324718 |
0.522 |
|
| 2003 |
Beider K, Nagler A, Wald O, Franitza S, Dagan-Berger M, Wald H, Giladi H, Brocke S, Hanna J, Mandelboim O, Darash-Yahana M, Galun E, Peled A. Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice. Blood. 102: 1951-8. PMID 12730102 DOI: 10.1182/Blood-2002-10-3293 |
0.544 |
|
| 2003 |
Aktas O, Waiczies S, Smorodchenko A, Dorr J, Seeger B, Prozorovski T, Sallach S, Endres M, Brocke S, Nitsch R, Zipp F. Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. The Journal of Experimental Medicine. 197: 725-33. PMID 12629065 DOI: 10.1084/Jem.20021425 |
0.647 |
|
| 2002 |
Reinhold D, Kähne T, Steinbrecher A, Wrenger S, Neubert K, Ansorge S, Brocke S. The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. Biological Chemistry. 383: 1133-8. PMID 12437097 DOI: 10.1515/Bc.2002.123 |
0.604 |
|
| 2001 |
Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N, Izikson L, Born I, Faust J, Neubert K, Martin R, Ansorge S, Brocke S. Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo. Journal of Immunology (Baltimore, Md. : 1950). 166: 2041-8. PMID 11160254 DOI: 10.4049/Jimmunol.166.3.2041 |
0.578 |
|
| 2000 |
Reinhold D, Hemmer B, Gran B, Steinbrecher A, Brocke S, Kähne T, Wrenger S, Born I, Faust J, Neubert K, Martin R, Ansorge S. Dipeptidyl peptidase IV (CD26): role in T cell activation and autoimmune disease. Advances in Experimental Medicine and Biology. 477: 155-60. PMID 10849742 DOI: 10.1007/0-306-46826-3_17 |
0.601 |
|
| 2000 |
Steinbrecher A, Reinhold D, Quigley L, Gado A, Tresser N, Izikson L, Born I, Faust J, Neubert K, Martin R, Ansorge S, Brocke S. Dipeptidyl peptidase IV in inflammatory CNS disease. Advances in Experimental Medicine and Biology. 477: 145-53. PMID 10849741 DOI: 10.1007/0-306-46826-3_16 |
0.638 |
|
| 1999 |
Brocke S, Piercy C, Steinman L, Weissman IL, Veromaa T. Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proceedings of the National Academy of Sciences of the United States of America. 96: 6896-901. PMID 10359810 DOI: 10.1073/Pnas.96.12.6896 |
0.564 |
|
| 1999 |
Jeong MC, Izikson L, Uccelli A, Brocke S, Oksenberg JR. Differential display analysis of murine encephalitogenic mRNA. International Immunology. 10: 1819-23. PMID 9885902 DOI: 10.1093/Intimm/10.12.1819 |
0.581 |
|
| 1998 |
Constantin G, Brocke S, Izikson A, Laudanna C, Butcher EC. Tyrphostin AG490, a tyrosine kinase inhibitor, blocks actively induced experimental autoimmune encephalomyelitis. European Journal of Immunology. 28: 3523-9. PMID 9842895 DOI: 10.1002/(Sici)1521-4141(199811)28:11<3523::Aid-Immu3523>3.0.Co;2-X |
0.444 |
|
| 1998 |
Ufret-Vincenty RL, Quigley L, Tresser N, Pak SH, Gado A, Hausmann S, Wucherpfennig KW, Brocke S. In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis. The Journal of Experimental Medicine. 188: 1725-38. PMID 9802984 DOI: 10.1084/Jem.188.9.1725 |
0.52 |
|
| 1998 |
Li W, Quigley L, Yao DL, Hudson LD, Brenner M, Zhang BJ, Brocke S, McFarland HF, Webster HD. Chronic relapsing experimental autoimmune encephalomyelitis: effects of insulin-like growth factor-I treatment on clinical deficits, lesion severity, glial responses, and blood brain barrier defects. Journal of Neuropathology and Experimental Neurology. 57: 426-38. PMID 9596413 DOI: 10.1097/00005072-199805000-00006 |
0.312 |
|
| 1998 |
Brocke S, Hausmann S, Steinman L, Wucherpfennig KW. Microbial peptides and superantigens in the pathogenesis of autoimmune diseases of the central nervous system. Seminars in Immunology. 10: 57-67. PMID 9529656 DOI: 10.1006/Smim.1997.0105 |
0.519 |
|
| 1997 |
Liblau R, Steinman L, Brocke S. Experimental autoimmune encephalomyelitis in IL-4-deficient mice. International Immunology. 9: 799-803. PMID 9184926 DOI: 10.1093/Intimm/9.5.799 |
0.44 |
|
| 1997 |
Shaw MK, Lorens JB, Dhawan A, DalCanto R, Tse HY, Tran AB, Bonpane C, Eswaran SL, Brocke S, Sarvetnick N, Steinman L, Nolan GP, Fathman CG. Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. The Journal of Experimental Medicine. 185: 1711-4. PMID 9151908 DOI: 10.1084/Jem.185.9.1711 |
0.53 |
|
| 1997 |
Gaur A, Boehme SA, Chalmers D, Crowe PD, Pahuja A, Ling N, Brocke S, Steinman L, Conlon PJ. Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms. Journal of Neuroimmunology. 74: 149-58. PMID 9119968 DOI: 10.1016/S0165-5728(96)00220-2 |
0.417 |
|
| 1997 |
Brocke S, Piercy C, Steinman L. Superantigens in demyelinating disease. Springer Seminars in Immunopathology. 18: 51-6. PMID 8984679 DOI: 10.1007/Bf00792608 |
0.527 |
|
| 1996 |
Waisman A, Ruiz PJ, Hirschberg DL, Gelman A, Oksenberg JR, Brocke S, Mor F, Cohen IR, Steinman L. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nature Medicine. 2: 899-905. PMID 8705860 DOI: 10.1038/Nm0896-899 |
0.475 |
|
| 1996 |
Brocke S, Gijbels K, Allegretta M, Ferber I, Piercy C, Blankenstein T, Martin R, Utz U, Karin N, Mitchell D, Veromaa T, Waisman A, Gaur A, Conlon P, Ling N, et al. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature. 379: 343-6. PMID 8552189 DOI: 10.1038/379343a0 |
0.51 |
|
| 1996 |
Brocke S, Quigley L, McFarland HF, Steinman L. Isolation and characterization of autoreactive T cells in experimental autoimmune encephalomyelitis of the mouse Methods: a Companion to Methods in Enzymology. 9: 458-462. DOI: 10.1006/Meth.1996.0053 |
0.599 |
|
| 1994 |
Brocke S, Veromaa T, Weissman IL, Gijbels K, Steinman L. Infection and multiple sclerosis: a possible role for superantigens? Trends in Microbiology. 2: 250-4. PMID 8081652 DOI: 10.1016/0966-842X(94)90630-0 |
0.503 |
|
| 1994 |
Karin N, Mitchell DJ, Brocke S, Ling N, Steinman L. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production. The Journal of Experimental Medicine. 180: 2227-37. PMID 7525850 DOI: 10.1084/Jem.180.6.2227 |
0.462 |
|
| 1993 |
Brocke S, Gaur A, Piercy C, Gautam A, Gijbels K, Fathman CG, Steinman L. Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen Nature. 365: 642-644. PMID 7692305 DOI: 10.1038/365642A0 |
0.572 |
|
| 1992 |
Brocke S, Chakraborty T, Mohasseb I, Reichert H, Lombardi O, Hahn H, Mielke M. Protective immunity and granulomatous inflammation is mediated in vivo by T cells reactive to epitopes common to avirulent and listeriolysin-negative mutants of Listeria monocytogenes. Cellular Immunology. 140: 42-53. PMID 1739988 DOI: 10.1016/0008-8749(92)90175-O |
0.536 |
|
| 1992 |
Mielke MEA, Rosen H, Brocke S, Peters C, Hahn H. Protective immunity and granuloma formation are mediated by two distinct tumor necrosis factor alpha- and gamma interferon-dependent T cell-phagocyte interactions in murine listeriosis: dissociation on the basis of phagocyte adhesion mechanisms. Infection and Immunity. 60: 1875-1882. PMID 1563777 DOI: 10.1128/Iai.60.5.1875-1882.1992 |
0.618 |
|
| 1991 |
Brocke S, Chakraborty T, Lombardi O, Hahn H, Mielke M. Listeriolysin negative mutants of listeria monocytogenes specifically stimulate T-lymphocytes mediating protection and granulomatous inflammation Zentralblatt Fur Bakteriologie-International Journal of Medical Microbiology Virology Parasitology and Infectious Diseases. 275: 112-117. PMID 1930559 DOI: 10.1016/S0934-8840(11)80774-7 |
0.537 |
|
| 1991 |
Brosh N, Lotan M, Eisenbach L, Brocke S, Tartakovsky B. Fertility impairment and improved fetal survival induced by a tumor cell line in mice American Journal of Reproductive Immunology. 26: 47-51. PMID 1741939 DOI: 10.1111/J.1600-0897.1991.Tb00702.X |
0.335 |
|
| 1991 |
Brocke S, Hahn H. Heat-killed Listeria monocytogenes and L. monocytogenes soluble antigen induce clonable CD4+ T lymphocytes with protective and chemotactic activities in vivo. Infection and Immunity. 59: 4531-4539. PMID 1682264 DOI: 10.1128/Iai.59.12.4531-4539.1991 |
0.597 |
|
| 1990 |
Brocke S, Dayan M, Steinman L, Rothbard J, Mozes E. Inhibition of T cell proliferation specific for acetylcholine receptor epitopes related to myasthenia gravis with antibody to T cell receptor or with competitive synthetic polymers. International Immunology. 2: 735-42. PMID 1707306 DOI: 10.1093/Intimm/2.8.735 |
0.467 |
|
| 1989 |
Brocke S, Brautbar C, Steinman L, Abramsky O, Rothbard J, Neumann D, Fuchs S, Mozes E. In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes. The Journal of Clinical Investigation. 82: 1894-900. PMID 2461962 DOI: 10.1172/Jci113807 |
0.326 |
|
| 1989 |
Mozes E, Dayan M, Zisman E, Brocke S, Licht A, Pecht I. Direct binding of a myasthenia gravis related epitope to MHC class II molecules on living murine antigen-presenting cells. The Embo Journal. 8: 4049-4052. DOI: 10.1002/J.1460-2075.1989.Tb08588.X |
0.507 |
|
| Show low-probability matches. |