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Cahir J O'Kane - Publications

Affiliations: 
Department of Genetics University of Cambridge, Cambridge, England, United Kingdom 
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14/64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Smith G, Sweeney ST, O'Kane CJ, Prokop A. How neurons maintain their axons long-term: an integrated view of axon biology and pathology. Frontiers in Neuroscience. 17: 1236815. PMID 37564364 DOI: 10.3389/fnins.2023.1236815  0.417
2023 Pérez-Moreno JJ, Smith RC, Oliva MK, Gallo F, Ojha S, Müller KH, O'Kane CJ. Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics. The Journal of Cell Biology. 222. PMID 36952540 DOI: 10.1083/jcb.202112101  0.681
2020 Oliva MK, Pérez-Moreno JJ, O'Shaughnessy J, Wardill TJ, O'Kane CJ. Endoplasmic Reticulum Lumenal Indicators in Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics. Frontiers in Neuroscience. 14: 816. PMID 32903680 DOI: 10.3389/fnins.2020.00816  0.692
2020 Öztürk Z, O'Kane CJ, Pérez-Moreno JJ. Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration. Frontiers in Neuroscience. 14: 48. PMID 32116502 DOI: 10.3389/fnins.2020.00048  0.664
2019 Pérez-Moreno JJ, O'Kane CJ. Drivers Specific for Type Ib and Type Is Motor Neurons in . G3 (Bethesda, Md.). 9: 453-462. PMID 30530644 DOI: 10.1534/g3.118.200809  0.635
2017 Yalçın B, Zhao L, Stofanko M, O'Sullivan NC, Kang ZH, Roost A, Thomas MR, Zaessinger S, Blard O, Patto AL, Sohail A, Baena V, Terasaki M, O'Kane CJ. Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins. Elife. 6. PMID 28742022 DOI: 10.7554/Elife.23882  0.478
2014 Masuda-Nakagawa LM, Ito K, Awasaki T, O'Kane CJ. A single GABAergic neuron mediates feedback of odor-evoked signals in the mushroom body of larval Drosophila. Frontiers in Neural Circuits. 8: 35. PMID 24782716 DOI: 10.3389/fncir.2014.00035  0.318
2012 O'Sullivan NC, Jahn TR, Reid E, O'Kane CJ. Reticulon-like-1, the Drosophila orthologue of the hereditary spastic paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons. Human Molecular Genetics. 21: 3356-65. PMID 22543973 DOI: 10.1093/hmg/dds167  0.453
2009 Tsang HT, Edwards TL, Wang X, Connell JW, Davies RJ, Durrington HJ, O'Kane CJ, Luzio JP, Reid E. The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling. Human Molecular Genetics. 18: 3805-21. PMID 19620182 DOI: 10.1093/hmg/ddp324  0.306
2008 Wang X, O'Kane CJ. Hereditary spastic paraplegia genes in Drosophila: dissecting their roles in axonal degeneration and intracellular traffic. Seb Experimental Biology Series. 60: 161-82. PMID 18309792  0.319
2007 Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan H, Zhou Y, Venken KJ, Shupliakov O, Robinson IM, O'Kane CJ, Bellen HJ. Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. The Journal of Cell Biology. 178: 309-22. PMID 17620409 DOI: 10.1083/jcb.200701030  0.472
2005 Ravikumar B, Acevedo-Arozena A, Imarisio S, Berger Z, Vacher C, O'Kane CJ, Brown SD, Rubinsztein DC. Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nature Genetics. 37: 771-6. PMID 15980862 DOI: 10.1038/Ng1591  0.302
2004 Ryder E, Blows F, Ashburner M, Bautista-Llacer R, Coulson D, Drummond J, Webster J, Gubb D, Gunton N, Johnson G, O'Kane CJ, Huen D, Sharma P, Asztalos Z, Baisch H, et al. The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. Genetics. 167: 797-813. PMID 15238529 DOI: 10.1534/Genetics.104.026658  0.448
2002 Bhattacharya S, Stewart BA, Niemeyer BA, Burgess RW, McCabe BD, Lin P, Boulianne G, O'Kane CJ, Schwarz TL. Members of the synaptobrevin/vesicle-associated membrane protein (VAMP) family in Drosophila are functionally interchangeable in vivo for neurotransmitter release and cell viability. Proceedings of the National Academy of Sciences of the United States of America. 99: 13867-72. PMID 12364587 DOI: 10.1073/pnas.202335999  0.314
Low-probability matches (unlikely to be authored by this person)
2011 Blackstone C, O'Kane CJ, Reid E. Hereditary spastic paraplegias: membrane traffic and the motor pathway. Nature Reviews. Neuroscience. 12: 31-42. PMID 21139634 DOI: 10.1038/Nrn2946  0.292
2016 Böhme MA, Beis C, Reddy-Alla S, Reynolds E, Mampell MM, Grasskamp AT, Lützkendorf J, Bergeron DD, Driller JH, Babikir H, Göttfert F, Robinson IM, O'Kane CJ, Hell SW, Wahl MC, et al. Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling. Nature Neuroscience. PMID 27526206 DOI: 10.1038/Nn.4364  0.281
2005 Rubinsztein DC, Ravikumar B, Acevedo-Arozena A, Imarisio S, O'Kane CJ, Brown SD. Dyneins, autophagy, aggregation and neurodegeneration. Autophagy. 1: 177-8. PMID 16874055 DOI: 10.4161/auto.1.3.2050  0.277
2021 Wong JYH, Wan BA, Bland T, Montagnese M, McLachlan AD, O'Kane CJ, Zhang SW, Masuda-Nakagawa LM. Octopaminergic neurons have multiple targets in larval mushroom body calyx and can modulate behavioral odor discrimination. Learning & Memory (Cold Spring Harbor, N.Y.). 28: 53-71. PMID 33452115 DOI: 10.1101/lm.052159.120  0.271
2007 Wang X, Shaw WR, Tsang HT, Reid E, O'Kane CJ. Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules. Nature Neuroscience. 10: 177-85. PMID 17220882 DOI: 10.1038/nn1841  0.266
2013 O'Sullivan NC, Dräger N, O'Kane CJ. Characterization of the Drosophila atlastin interactome reveals VCP as a functionally related interactor. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 40: 297-306. PMID 23790629 DOI: 10.1016/j.jgg.2013.04.008  0.265
2002 Keller A, Sweeney ST, Zars T, O'Kane CJ, Heisenberg M. Targeted expression of tetanus neurotoxin interferes with behavioral responses to sensory input in Drosophila. Journal of Neurobiology. 50: 221-33. PMID 11810637 DOI: 10.1002/neu.10029  0.25
2010 Masuda-Nakagawa LM, Awasaki T, Ito K, O'Kane CJ. Targeting expression to projection neurons that innervate specific mushroom body calyx and antennal lobe glomeruli in larval Drosophila. Gene Expression Patterns : Gep. 10: 328-37. PMID 20659588 DOI: 10.1016/j.gep.2010.07.004  0.245
2005 Masuda-Nakagawa LM, Tanaka NK, O'Kane CJ. Stereotypic and random patterns of connectivity in the larval mushroom body calyx of Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 102: 19027-32. PMID 16357192 DOI: 10.1073/pnas.0509643102  0.244
2010 Lone M, Kungl T, Koper A, Bottenberg W, Kammerer R, Klein M, Sweeney ST, Auburn RP, O'Kane CJ, Prokop A. The nuclear protein Waharan is required for endosomal-lysosomal trafficking in Drosophila. Journal of Cell Science. 123: 2369-74. PMID 20551180 DOI: 10.1242/Jcs.060582  0.227
2016 Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC. CCT complex restricts neuropathogenic protein aggregation via autophagy. Nature Communications. 7: 13821. PMID 27929117 DOI: 10.1038/ncomms13821  0.219
2005 Hodge JJ, Choi JC, O'Kane CJ, Griffith LC. Shaw potassium channel genes in Drosophila. Journal of Neurobiology. 63: 235-54. PMID 15751025 DOI: 10.1002/neu.20126  0.217
2007 Korolchuk VI, Schütz MM, Gómez-Llorente C, Rocha J, Lansu NR, Collins SM, Wairkar YP, Robinson IM, O'Kane CJ. Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation. Journal of Cell Science. 120: 4367-76. PMID 18057029 DOI: 10.1242/Jcs.012336  0.216
2008 Ravikumar B, Imarisio S, Sarkar S, O'Kane CJ, Rubinsztein DC. Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease. Journal of Cell Science. 121: 1649-60. PMID 18430781 DOI: 10.1242/jcs.025726  0.215
2004 Mistry H, Wilson BA, Roberts IJ, O'Kane CJ, Skeath JB. Cullin-3 regulates pattern formation, external sensory organ development and cell survival during Drosophila development. Mechanisms of Development. 121: 1495-507. PMID 15511641 DOI: 10.1016/J.Mod.2004.07.007  0.197
2005 Gissen P, Johnson CA, Gentle D, Hurst LD, Doherty AJ, O'Kane CJ, Kelly DA, Maher ER. Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. Human Molecular Genetics. 14: 1261-70. PMID 15790593 DOI: 10.1093/hmg/ddi137  0.194
2008 Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA, Rubinsztein DC. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nature Chemical Biology. 4: 295-305. PMID 18391949 DOI: 10.1038/nchembio.79  0.191
2023 Mohamed A, Malekou I, Sim T, O'Kane CJ, Maait Y, Scullion B, Masuda-Nakagawa LM. Mushroom body output neurons MBON-a1/a2 define an odor intensity channel that regulates behavioral odor discrimination learning in larval . Frontiers in Physiology. 14: 1111244. PMID 37256074 DOI: 10.3389/fphys.2023.1111244  0.19
2009 Nikolaev A, Zheng L, Wardill TJ, O'Kane CJ, de Polavieja GG, Juusola M. Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms. Plos One. 4: e4306. PMID 19180195 DOI: 10.1371/journal.pone.0004306  0.189
2006 Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, Schmitt I, Wullner U, Evert BO, O'Kane CJ, Rubinsztein DC. Rapamycin alleviates toxicity of different aggregate-prone proteins. Human Molecular Genetics. 15: 433-42. PMID 16368705 DOI: 10.1093/Hmg/Ddi458  0.184
2006 Berger Z, Davies JE, Luo S, Pasco MY, Majoul I, O'Kane CJ, Rubinsztein DC. Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion Human Molecular Genetics. 15: 453-465. PMID 16371423 DOI: 10.1093/Hmg/Ddi460  0.182
2010 Menzies FM, Hourez R, Imarisio S, Raspe M, Sadiq O, Chandraratna D, O'Kane C, Rock KL, Reits E, Goldberg AL, Rubinsztein DC. Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. Human Molecular Genetics. 19: 4573-86. PMID 20829225 DOI: 10.1093/hmg/ddq385  0.182
2023 Court R, Costa M, Pilgrim C, Millburn G, Holmes A, McLachlan A, Larkin A, Matentzoglu N, Kir H, Parkinson H, Brown NH, O'Kane CJ, Armstrong JD, Jefferis GSXE, Osumi-Sutherland D. Virtual Fly Brain-An interactive atlas of the nervous system. Frontiers in Physiology. 14: 1076533. PMID 36776967 DOI: 10.3389/fphys.2023.1076533  0.178
2009 Zheng L, Nikolaev A, Wardill TJ, O'Kane CJ, de Polavieja GG, Juusola M. Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: I dynamics. Plos One. 4: e4307. PMID 19180196 DOI: 10.1371/Journal.Pone.0004307  0.176
2009 Masuda-Nakagawa LM, Gendre N, O'Kane CJ, Stocker RF. Localized olfactory representation in mushroom bodies of Drosophila larvae. Proceedings of the National Academy of Sciences of the United States of America. 106: 10314-9. PMID 19502424 DOI: 10.1073/pnas.0900178106  0.168
2005 Berger Z, Ttofi EK, Michel CH, Pasco MY, Tenant S, Rubinsztein DC, O'Kane CJ. Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway Human Molecular Genetics. 14: 3003-3011. PMID 16141285 DOI: 10.1093/Hmg/Ddi331  0.163
2003 Liu H, Mardahl-Dumesnil M, Sweeney ST, O'Kane CJ, Bernstein SI. Drosophila paramyosin is important for myoblast fusion and essential for myofibril formation. The Journal of Cell Biology. 160: 899-908. PMID 12642615 DOI: 10.1083/Jcb.200208180  0.158
2015 Jimenez-Sanchez M, Lam W, Hannus M, Sönnichsen B, Imarisio S, Fleming A, Tarditi A, Menzies F, Ed Dami T, Xu C, Gonzalez-Couto E, Lazzeroni G, Heitz F, Diamanti D, Massai L, et al. siRNA screen identifies QPCT as a druggable target for Huntington's disease. Nature Chemical Biology. 11: 347-54. PMID 25848931 DOI: 10.1038/Nchembio.1790  0.156
2011 Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC. Lysosomal positioning coordinates cellular nutrient responses. Nature Cell Biology. 13: 453-60. PMID 21394080 DOI: 10.1038/Ncb2204  0.149
2022 Osumi-Sutherland D, Costa M, Court R, O'Kane CJ. Virtual Fly Brain - Using OWL to support the mapping and genetic dissection of the brain. Ceur Workshop Proceedings. 1265: 85-96. PMID 29724079  0.148
2007 Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Human Molecular Genetics. 17: 170-8. PMID 17921520 DOI: 10.1093/HMG/DDM294  0.142
2014 Moreau K, Fleming A, Imarisio S, Lopez Ramirez A, Mercer JL, Jimenez-Sanchez M, Bento CF, Puri C, Zavodszky E, Siddiqi F, Lavau CP, Betton M, O'Kane CJ, Wechsler DS, Rubinsztein DC. PICALM modulates autophagy activity and tau accumulation. Nature Communications. 5: 4998. PMID 25241929 DOI: 10.1038/ncomms5998  0.138
2007 Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nature Chemical Biology. 3: 331-8. PMID 17486044 DOI: 10.1038/Nchembio883  0.138
2013 Na D, Rouf M, O'Kane CJ, Rubinsztein DC, Gsponer J. NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases. Bmc Medical Genomics. 6: 52. PMID 24229347 DOI: 10.1186/1755-8794-6-52  0.135
2004 Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, Rubinsztein DC. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nature Genetics. 36: 585-95. PMID 15146184 DOI: 10.1038/Ng1362  0.135
2016 O'Kane CJ. Drosophila as a model organism for the study of neuropsychiatric disorders. Current Topics in Behavioral Neurosciences. 7: 37-60. PMID 21225410 DOI: 10.1007/7854_2010_110  0.134
2004 Liu H, Mardahl-Dumesnil M, Sweeney ST, O'Kane CJ, Bernstein SI. Drosophila paramyosin is important for myoblast fusion and essential for myofibril formation. The Journal of Cell Biology. 167: 783. PMID 15557126 DOI: 10.1083/jcb.200208180101804r  0.134
2011 Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-Arencibia M, Rose C, Luo S, Underwood BR, Kroemer G, O'Kane CJ, Rubinsztein DC. Complex inhibitory effects of nitric oxide on autophagy. Molecular Cell. 43: 19-32. PMID 21726807 DOI: 10.1016/J.Molcel.2011.04.029  0.129
2006 Ravikumar B, Berger Z, Vacher C, O'Kane CJ, Rubinsztein DC. Rapamycin pre-treatment protects against apoptosis. Human Molecular Genetics. 15: 1209-16. PMID 16497721 DOI: 10.1093/Hmg/Ddl036  0.126
2002 Chan HY, Tung CK, O'Kane CJ. Rev-GFP transgenic lines for studies of nucleocytoplasmic transport in Drosophila. Genesis (New York, N.Y. : 2000). 34: 139-41. PMID 12324969 DOI: 10.1002/gene.10121  0.124
2002 Allen MJ, O'Kane CJ, Moffat KG. Cell ablation using wild-type and cold-sensitive ricin-A chain in Drosophila embryonic mesoderm. Genesis (New York, N.Y. : 2000). 34: 132-4. PMID 12324967 DOI: 10.1002/gene.10129  0.122
2009 Sharma P, Keane J, O'Kane CJ, Asztalos Z. Automated measurement of Drosophila jump reflex habituation and its use for mutant screening. Journal of Neuroscience Methods. 182: 43-8. PMID 19520114 DOI: 10.1016/j.jneumeth.2009.05.024  0.119
2005 Sharma P, Asztalos Z, Ayyub C, de Bruyne M, Dornan AJ, Gomez-Hernandez A, Keane J, Killeen J, Kramer S, Madhavan M, Roe H, Sherkhane PD, Siddiqi K, Silva E, Carlson JR, et al. Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster. Journal of Neurogenetics. 19: 57-85. PMID 16024440 DOI: 10.1080/01677060591007155  0.116
2010 Underwood BR, Imarisio S, Fleming A, Rose C, Krishna G, Heard P, Quick M, Korolchuk VI, Renna M, Sarkar S, García-Arencibia M, O'Kane CJ, Murphy MP, Rubinsztein DC. Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease. Human Molecular Genetics. 19: 3413-29. PMID 20566712 DOI: 10.1093/Hmg/Ddq253  0.106
2020 Smith HK, O'Kane CJ. Use of a cytoplasmically localised P-lacZ fusion to identify cell shapes by enhancer trapping inDrosophila. Roux's Archives of Developmental Biology : the Official Organ of the Edbo. 200: 306-311. PMID 28305904 DOI: 10.1007/BF00665525  0.098
2010 Winslow AR, Chen CW, Corrochano S, Acevedo-Arozena A, Gordon DE, Peden AA, Lichtenberg M, Menzies FM, Ravikumar B, Imarisio S, Brown S, O'Kane CJ, Rubinsztein DC. α-Synuclein impairs macroautophagy: implications for Parkinson's disease. The Journal of Cell Biology. 190: 1023-37. PMID 20855506 DOI: 10.1083/jcb.201003122  0.098
2003 O'Kane CJ. Modelling human diseases in Drosophila and Caenorhabditis. Seminars in Cell & Developmental Biology. 14: 3-10. PMID 12524001 DOI: 10.1016/s1084-9521(02)00162-3  0.079
2021 Martinuzzi A, Blackstone C, O'Kane CJ, Stevanin G. Editorial: Hereditary Spastic Paraplegias: At the Crossroads of Molecular Pathways and Clinical Options. Frontiers in Neuroscience. 15: 708642. PMID 34239414 DOI: 10.3389/fnins.2021.708642  0.065
2012 Wardill TJ, List O, Li X, Dongre S, McCulloch M, Ting CY, O'Kane CJ, Tang S, Lee CH, Hardie RC, Juusola M. Multiple spectral inputs improve motion discrimination in the Drosophila visual system. Science (New York, N.Y.). 336: 925-31. PMID 22605779 DOI: 10.1126/Science.1215317  0.035
2011 Rocha JJ, Korolchuk VI, Robinson IM, O'Kane CJ. A phagocytic route for uptake of double-stranded RNA in RNAi. Plos One. 6: e19087. PMID 21559499 DOI: 10.1371/journal.pone.0019087  0.01
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