| Year |
Citation |
Score |
| 2024 |
Fenske RJ, Wienkes HN, Peter DC, Schaid MD, Hurley LD, Pennati A, Galipeau J, Kimple ME. Gα-independent and -dependent Improvements With EPA Supplementation on the Early Type 1 Diabetes Phenotype of NOD Mice. Journal of the Endocrine Society. 8: bvae100. PMID 38831864 DOI: 10.1210/jendso/bvae100 |
0.432 |
|
| 2024 |
Neuman JC, Reuter A, Carbajal KA, Schaid MD, Kelly G, Connors K, Kaiser C, Krause J, Hurley LD, Olvera A, Davis DB, Wisinski JA, Gannon M, Kimple ME. The Prostaglandin E EP3 Receptor Has Disparate Effects on Islet Insulin Secretion and Content in β-cells in a High Fat Diet-induced Mouse Model of Obesity. American Journal of Physiology. Endocrinology and Metabolism. PMID 38477664 DOI: 10.1152/ajpendo.00061.2023 |
0.422 |
|
| 2023 |
Schaid MD, Harrington JM, Kelly GM, Sdao SM, Merrins MJ, Kimple ME. EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance. Islets. 15: 2223327. PMID 37415404 DOI: 10.1080/19382014.2023.2223327 |
0.409 |
|
| 2022 |
Fenske RJ, Weeks AM, Daniels M, Nall R, Pabich S, Brill AL, Peter DC, Punt M, Cox ED, Davis DB, Kimple ME. Plasma Prostaglandin E Metabolite Levels Predict Type 2 Diabetes Status and One-Year Therapeutic Response Independent of Clinical Markers of Inflammation. Metabolites. 12. PMID 36557272 DOI: 10.3390/metabo12121234 |
0.753 |
|
| 2022 |
Bosma KJ, Kaiser CE, Kimple ME, Gannon M. Effects of Arachidonic Acid and Its Metabolites on Functional Beta-Cell Mass. Metabolites. 12. PMID 35448529 DOI: 10.3390/metabo12040342 |
0.304 |
|
| 2021 |
Bosma KJ, Andrei SR, Katz LS, Smith AA, Dunn JC, Ricciardi VF, Ramirez MA, Baumel-Alterzon S, Pace WA, Carroll DT, Overway EM, Wolf EM, Kimple ME, Sheng Q, Scott DK, et al. Pharmacological blockade of the EP3 prostaglandin E receptor in the setting of Type 2 diabetes enhances β-cell proliferation and identity, and relieves oxidative damage. Molecular Metabolism. 101347. PMID 34626853 DOI: 10.1016/j.molmet.2021.101347 |
0.376 |
|
| 2021 |
Truchan NA, Fenske RJ, Sandhu HK, Weeks AM, Patibandla C, Wancewicz B, Pabich S, Reuter A, Harrington JM, Brill AL, Peter DC, Nall R, Daniels M, Punt M, Kaiser CE, ... ... Kimple ME, et al. Human Islet Expression Levels of Prostaglandin E Synthetic Enzymes, But Not Prostaglandin EP3 Receptor, Are Positively Correlated with Markers of β-Cell Function and Mass in Nondiabetic Obesity. Acs Pharmacology & Translational Science. 4: 1338-1348. PMID 34423270 DOI: 10.1021/acsptsci.1c00045 |
0.744 |
|
| 2021 |
Wisinski J, Reuter A, Peter DC, Schaid MD, Fenske RJ, Kimple ME. Prostaglandin EP3 Receptor signaling is required to prevent insulin hypersecretion and metabolic dysfunction in a non-obese mouse model of insulin resistance. American Journal of Physiology. Endocrinology and Metabolism. PMID 34229444 DOI: 10.1152/ajpendo.00051.2021 |
0.417 |
|
| 2021 |
Sandhu HK, Neuman JC, Schaid MD, Davis SE, Connors KM, Challa R, Guthery E, Fenske RJ, Patibandla C, Breyer RM, Kimple ME. Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion. Pharmacology Research & Perspectives. 9: e00736. PMID 33694300 DOI: 10.1002/prp2.736 |
0.366 |
|
| 2021 |
Schaid MD, Zhu Y, Richardson NE, Patibandla C, Ong IM, Fenske RJ, Neuman JC, Guthery E, Reuter A, Sandhu HK, Fuller MH, Cox ED, Davis DB, Layden BT, Brasier AR, ... ... Kimple ME, et al. Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes. Metabolites. 11. PMID 33467110 DOI: 10.3390/metabo11010058 |
0.414 |
|
| 2020 |
Schaid MD, Green CL, Peter DC, Gallagher SJ, Guthery E, Carbajal KA, Harrington JM, Kelly GM, Reuter A, Wehner ML, Brill AL, Neuman JC, Lamming DW, Kimple ME. Agonist-independent Gα activity negatively regulates β-cell compensation in a diet-induced obesity model of type 2 diabetes. The Journal of Biological Chemistry. PMID 33172888 DOI: 10.1074/jbc.RA120.015585 |
0.768 |
|
| 2020 |
Lee H, Fenske RJ, Akcan T, Domask E, Davis DB, Kimple ME, Engin F. Differential Expression of Ormdl Genes in the Islets of Mice and Humans with Obesity. Iscience. 23: 101324. PMID 32659722 DOI: 10.1016/J.Isci.2020.101324 |
0.406 |
|
| 2020 |
Carbajal K, Schaid M, Green C, Laundre E, Harrington J, Kelly G, Reuter A, Fenske R, Wehner M, Lamming D, Kimple M. Loss of β‐cell Gα
z
protects against high‐fat diet induced glucose intolerance by preserving incretin responsiveness and enhancing insulin secretion The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04098 |
0.395 |
|
| 2020 |
Peter D, Fenske R, Wienkes H, Reuter A, Carbajal K, Kimple ME. Beta‐cell‐specific Loss of the Inhibitory G protein, Gα
z
, has Sex‐dependent Effects on Development and Pathophysiology of Type 1 Diabetes The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03523 |
0.386 |
|
| 2019 |
Koltes JE, Arora I, Gupta R, Nguyen DC, Schaid M, Kim JA, Kimple ME, Bhatnagar S. A gene expression network analysis of the pancreatic islets from lean and obese mice identifies complement 1q like-3 secreted protein as a regulator of β-cell function. Scientific Reports. 9: 10119. PMID 31300714 DOI: 10.1038/S41598-019-46219-3 |
0.494 |
|
| 2019 |
Gupta R, Nguyen D, Schaid M, Kimple M, Bhatnagar S. SAT-168 A Secreted Protein Complement 1q Like-3 Protein Inhibits Insulin Secretion by an Adhesion G-Protein Coupled Receptor, BAI3 in Pancreatic β-Cells Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Sat-168 |
0.454 |
|
| 2018 |
De Leon ER, Brinkman JA, Fenske RJ, Gregg T, Schmidt BA, Sherman DS, Cummings NE, Peter DC, Kimple ME, Lamming DW, Merrins MJ. Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice. Scientific Reports. 8: 17814. PMID 30546031 DOI: 10.1038/S41598-018-36289-0 |
0.447 |
|
| 2018 |
Gupta R, Nguyen DC, Schaid MD, Lei X, Balamurugan AN, Wong GW, Kim JA, Koltes JE, Kimple ME, Bhatnagar S. Complement 1q like-3 protein inhibits insulin secretion from pancreatic β-cells via the cell adhesion G protein-coupled receptor BAI3. The Journal of Biological Chemistry. PMID 30228187 DOI: 10.1074/Jbc.Ra118.005403 |
0.529 |
|
| 2018 |
Fenske RJ, Kimple ME. Targeting dysfunctional beta-cell signaling for the potential treatment of type 1 diabetes mellitus. Experimental Biology and Medicine (Maywood, N.J.). 1535370218761662. PMID 29504478 DOI: 10.1177/1535370218761662 |
0.479 |
|
| 2018 |
Yu D, Yang SE, Miller BR, Wisinski JA, Sherman DS, Brinkman JA, Tomasiewicz JL, Cummings NE, Kimple ME, Cryns VL, Lamming DW. Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701211R. PMID 29401631 DOI: 10.1096/Fj.201701211R |
0.349 |
|
| 2018 |
GUPTA R, SCHAID M, KIMPLE ME, KOLTES JE, BHATNAGAR S. The Complement-1q-Like-3 Inhibits Insulin Secretion by an Adhesion G-Protein Coupled Receptor, BAI3 in Pancreatic ß Cells Diabetes. 67: 2159-P. DOI: 10.2337/Db18-2159-P |
0.563 |
|
| 2017 |
Cummings NE, Williams EM, Kasza I, Konon EN, Schaid MD, Schmidt BA, Poudel C, Sherman DS, Yu D, Arriola Apelo SI, Cottrell SE, Geiger G, Barnes ME, Wisinski JA, Fenske RJ, ... ... Kimple ME, et al. Restoration of metabolic health by decreased consumption of branched-chain amino acids. The Journal of Physiology. PMID 29266268 DOI: 10.1113/Jp275075 |
0.38 |
|
| 2017 |
Rodriguez CI, Castro-Perez E, Prabhakar K, Block L, Longley BJ, Wisinski JA, Kimple ME, Setaluri V. EPAC-RAP1 Axis-mediated Switch in the Response of Primary and Metastatic Melanoma to cyclic AMP. Molecular Cancer Research : McR. PMID 28851815 DOI: 10.1158/1541-7786.Mcr-17-0067 |
0.342 |
|
| 2017 |
Schaid MD, Wisinski JA, Kimple ME. The EP3 Receptor/Gz Signaling Axis as a Therapeutic Target for Diabetes and Cardiovascular Disease. The Aaps Journal. PMID 28584908 DOI: 10.1208/S12248-017-0097-1 |
0.437 |
|
| 2017 |
Carboneau BA, Allan JA, Townsend SE, Kimple ME, Breyer RM, Gannon M. Opposing effects of prostaglandin E2 receptors EP3 and EP4 on mouse and human β-cell survival and proliferation. Molecular Metabolism. 6: 548-559. PMID 28580285 DOI: 10.1016/J.Molmet.2017.04.002 |
0.434 |
|
| 2017 |
Hernandez R, Graves SA, Gregg T, VanDeusen HR, Fenske RJ, Wienkes HN, England CG, Valdovinos HF, Jeffery JJ, Barnhart TE, Severin GW, Nickles RJ, Kimple ME, Merrins MJ, Cai W. Radiomanganese PET Detects Changes in Functional β-cell Mass in Mouse Models of Diabetes. Diabetes. PMID 28515126 DOI: 10.2337/Db16-1285 |
0.423 |
|
| 2017 |
Fenske RJ, Cadena MT, Harenda QE, Wienkes HN, Carbajal K, Schaid MD, Laundre E, Brill AL, Truchan NA, Brar H, Wisinski J, Cai J, Graham TE, Engin F, Kimple ME. The inhibitory G-protein α-subunit, Gαz, promotes Type 1 diabetes-like pathophysiology in NOD mice. Endocrinology. PMID 28419211 DOI: 10.1210/En.2016-1700 |
0.762 |
|
| 2017 |
Neuman JC, Schaid MD, Brill AL, Fenske RJ, Kibbe CR, Fontaine DA, Sdao SM, Brar HK, Connors KM, Wienkes HN, Eliceiri KW, Merrins MJ, Davis DB, Kimple ME. Enriching Islet Phospholipids with Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic β-cell Function. Diabetes. PMID 28193789 DOI: 10.2337/Db16-1362 |
0.773 |
|
| 2017 |
Fenske R, Weeks A, Brill A, Nall R, Pabitch S, Punt M, Daniels M, Blaha S, Davis DB, Kimple M. Prostaglandin E2 (PGE2) Levels As a Predictor of Type 2 Diabetes Control in Human Subjects: A cross-sectional view of initial cohort study data The Faseb Journal. 31. DOI: 10.1096/Fasebj.31.1_Supplement.675.6 |
0.746 |
|
| 2016 |
Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ. Pancreatic β cells from Mice Offset Age-Associated Mitochondrial Deficiency with Reduced KATP Channel Activity. Diabetes. PMID 27284112 DOI: 10.2337/Db16-0432 |
0.437 |
|
| 2016 |
Brill AL, Wisinski JA, Cadena MT, Thompson MF, Fenske RJ, Brar HK, Schaid MD, Pasker RL, Kimple ME. Synergy between Gαz deficiency and GLP-1 analog treatment in preserving functional beta-cell mass in experimental diabetes. Molecular Endocrinology (Baltimore, Md.). me20151164. PMID 27049466 DOI: 10.1210/Me.2015-1164 |
0.753 |
|
| 2016 |
Wisinski JA, Kimple ME. Platelet Dysfunction in Type 1 Diabetes: Stressing the Thromboxanes. Diabetes. 65: 349-51. PMID 26798121 DOI: 10.2337/Dbi15-0032 |
0.384 |
|
| 2016 |
Arriola Apelo SI, Neuman JC, Baar EL, Syed FA, Cummings NE, Brar HK, Pumper CP, Kimple ME, Lamming DW. Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system. Aging Cell. 15: 28-38. PMID 26463117 DOI: 10.1111/Acel.12405 |
0.38 |
|
| 2016 |
Apelo SA, Pumper C, Baar E, Cummings N, Brar H, Kimple M, Lamming D, Neuman J. Id: 21: Alternative Rapamycin Treatment Regimens Mitigate The Impact Of Rapamycin On Glucose Homeostasis And The Immune System, And Extends Lifespan Journal of Investigative Medicine. 64: 932-933. DOI: 10.1136/Jim-2016-000120.45 |
0.373 |
|
| 2016 |
Lamming D, Cummings N, Arriola Apelo S, Neuman J, Schmidt B, Merrins M, Kimple M, Fontana L. ID: 78: IMPROVING GLYCEMIC CONTROL THROUGH REDUCTION OF SPECIFIC DIETARY AMINO ACIDS Journal of Investigative Medicine. 64: 926.1-926. DOI: 10.1136/Jim-2016-000120.32 |
0.402 |
|
| 2015 |
Truchan NA, Brar HK, Gallagher SJ, Neuman JC, Kimple ME. A single-islet microplate assay to measure mouse and human islet insulin secretion. Islets. 0. PMID 26452321 DOI: 10.1080/19382014.2015.1076607 |
0.449 |
|
| 2015 |
Pierre JF, Neuman JC, Brill AL, Brar HK, Thompson MF, Cadena MT, Connors KM, Busch RA, Heneghan AF, Cham CM, Jones EK, Kibbe CR, Davis DB, Groblewski GE, Kudsk KA, ... Kimple ME, et al. The gastrin-releasing peptide analog bombesin preserves exocrine and endocrine pancreas morphology and function during parenteral nutrition. American Journal of Physiology. Gastrointestinal and Liver Physiology. 309: G431-42. PMID 26185331 DOI: 10.1152/Ajpgi.00072.2015 |
0.745 |
|
| 2015 |
Oropeza D, Jouvet N, Budry L, Campbell JE, Bouyakdan K, Lacombe J, Perron G, Bergeron V, Neuman JC, Brar HK, Fenske RJ, Meunier C, Sczelecki S, Kimple ME, Drucker DJ, et al. Phenotypic characterization of MIP-CreERT1Lphi mice with transgene-driven islet expression of human growth hormone. Diabetes. PMID 26153246 DOI: 10.2337/Db15-0272 |
0.496 |
|
| 2015 |
Linnemann AK, Neuman JC, Battiola TJ, Wisinski JA, Kimple ME, Davis DB. Glucagon-like peptide-1 Regulates Cholecystokinin Production in β-cells to Protect from Apoptosis. Molecular Endocrinology (Baltimore, Md.). me20151030. PMID 25984632 DOI: 10.1210/Me.2015-1030 |
0.49 |
|
| 2015 |
Busch RA, Heneghan AF, Pierre JF, Neuman JC, Reimer CA, Wang X, Kimple ME, Kudsk KA. Bombesin Preserves Goblet Cell Resistin-like Molecule β During Parenteral Nutrition but Not Other Goblet Cell Products. Jpen. Journal of Parenteral and Enteral Nutrition. PMID 25934045 DOI: 10.1177/0148607115585353 |
0.346 |
|
| 2014 |
Neuman JC, Truchan NA, Joseph JW, Kimple ME. A method for mouse pancreatic islet isolation and intracellular cAMP determination. Journal of Visualized Experiments : Jove. e50374. PMID 24998772 DOI: 10.3791/50374 |
0.545 |
|
| 2014 |
Kimple ME, Neuman JC, Linnemann AK, Casey PJ. Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes. Experimental & Molecular Medicine. 46: e102. PMID 24946790 DOI: 10.1038/Emm.2014.40 |
0.49 |
|
| 2013 |
Kimple ME, Brill AL, Pasker RL. Overview of affinity tags for protein purification. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. 73: Unit 9.9. PMID 24510596 DOI: 10.1002/0471140864.Ps0909S73 |
0.701 |
|
| 2013 |
Krautkramer KA, Linnemann AK, Fontaine DA, Whillock AL, Harris TW, Schleis GJ, Truchan NA, Marty-Santos L, Lavine JA, Cleaver O, Kimple ME, Davis DB. Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell line. American Journal of Physiology. Endocrinology and Metabolism. 305: E600-10. PMID 23860123 DOI: 10.1152/Ajpendo.00147.2013 |
0.418 |
|
| 2013 |
Kimple ME, Keller MP, Rabaglia MR, Pasker RL, Neuman JC, Truchan NA, Brar HK, Attie AD. Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion. Diabetes. 62: 1904-12. PMID 23349487 DOI: 10.2337/Db12-0769 |
0.548 |
|
| 2012 |
Kimple ME, Moss JB, Brar HK, Rosa TC, Truchan NA, Pasker RL, Newgard CB, Casey PJ. Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. The Journal of Biological Chemistry. 287: 20344-55. PMID 22457354 DOI: 10.1074/Jbc.M112.359745 |
0.536 |
|
| 2010 |
Kelly P, Bailey CL, Fueger PT, Newgard CB, Casey PJ, Kimple ME. Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation. The Journal of Biological Chemistry. 285: 15777-85. PMID 20339002 DOI: 10.1074/Jbc.M109.069112 |
0.475 |
|
| 2010 |
Kimple ME, Hultman RC, Casey PJ. Signaling through Gz Handbook of Cell Signaling, 2/E. 2: 1649-1653. DOI: 10.1016/B978-0-12-374145-5.00202-3 |
0.32 |
|
| 2008 |
Kimple ME, Joseph JW, Bailey CL, Fueger PT, Hendry IA, Newgard CB, Casey PJ. Galphaz negatively regulates insulin secretion and glucose clearance. The Journal of Biological Chemistry. 283: 4560-7. PMID 18096703 DOI: 10.1074/Jbc.M706481200 |
0.498 |
|
| 2005 |
Kimple ME, Nixon AB, Kelly P, Bailey CL, Young KH, Fields TA, Casey PJ. A role for G(z) in pancreatic islet beta-cell biology. The Journal of Biological Chemistry. 280: 31708-13. PMID 16157560 DOI: 10.1074/Jbc.M506700200 |
0.465 |
|
| 2005 |
Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon JE. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Molecular Cell. 19: 197-207. PMID 16039589 DOI: 10.1016/J.Molcel.2005.06.008 |
0.42 |
|
| 2004 |
Kimple ME, Sondek J. Overview of affinity tags for protein purification. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 9.9. PMID 18429272 DOI: 10.1002/0471140864.ps0909s36 |
0.569 |
|
| 2002 |
Kimple ME, Sondek J. Affinity tag for protein purification and detection based on the disulfide-linked complex of InaD and NorpA. Biotechniques. 33: 578, 580, 584-8 pass. PMID 12238768 DOI: 10.2144/02333Rr01 |
0.6 |
|
| 2002 |
Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature. 416: 878-81. PMID 11976690 DOI: 10.1038/416878A |
0.614 |
|
| 2001 |
Kimple ME, Siderovski DP, Sondek J. Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA Embo Journal. 20: 4414-4422. PMID 11500369 DOI: 10.1093/Emboj/20.16.4414 |
0.587 |
|
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