| Year |
Citation |
Score |
| 2024 |
Wuo MG, Dulberger CL, Warner TC, Brown RA, Sturm A, Ultee E, Bloom-Ackermann Z, Choi C, Zhu J, Garner EC, Briegel A, Hung DT, Rubin EJ, Kiessling LL. Fluorogenic Probes of the Mycobacterial Membrane as Reporters of Antibiotic Action. Journal of the American Chemical Society. PMID 38905328 DOI: 10.1021/jacs.4c00617 |
0.798 |
|
| 2024 |
Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Shigeta JY, Mashin E, Salm EJ, Choi C, Combs S, Lee JSW, Rodriguez-Osorio C, Clish C, Tomita S, Hung DT. 3-Hydroxykynurenine targets kainate receptors to promote defense against infection. Nature Chemical Biology. PMID 38898166 DOI: 10.1038/s41589-024-01635-z |
0.747 |
|
| 2024 |
Romano KP, Bagnall J, Warrier T, Sullivan J, Ferrara K, Orzechowski M, Nguyen PH, Raines K, Livny J, Shoresh N, Hung DT. Perturbation-Specific Transcriptional Mapping facilitates unbiased target elucidation of antibiotics. Biorxiv : the Preprint Server For Biology. PMID 38712067 DOI: 10.1101/2024.04.25.590978 |
0.792 |
|
| 2024 |
Tse MW, Zhu M, Peters B, Hamami E, Chen J, Davis KP, Nitz S, Weller J, Warrier T, Hunt DK, Morales Y, Kawate T, Gaulin JL, Come JH, Hernandez-Bird J, ... ... Hung DT, et al. Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens. Biorxiv : the Preprint Server For Biology. PMID 38585790 DOI: 10.1101/2024.03.26.586803 |
0.539 |
|
| 2024 |
Poulsen BE, Warrier T, Barkho S, Bagnall J, Romano KP, White T, Yu X, Kawate T, Nguyen PH, Raines K, Ferrara K, Golas A, Fitzgerald M, Boeszoermenyi A, Kaushik V, ... ... Hung DT, et al. "Multiplexed screen identifies a -specific small molecule targeting the outer membrane protein OprH and its interaction with LPS". Biorxiv : the Preprint Server For Biology. PMID 38559044 DOI: 10.1101/2024.03.16.585348 |
0.806 |
|
| 2024 |
Neo DM, Clatworthy AE, Hung DT. A dual-plasmid CRISPR/Cas9-based method for rapid and efficient genetic disruption in . Journal of Bacteriology. e0033523. PMID 38319218 DOI: 10.1128/jb.00335-23 |
0.744 |
|
| 2024 |
Sturm A, Sun P, Avila-Pacheco J, Clatworthy AE, Bloom-Ackermann Z, Wuo MG, Gomez JE, Jin S, Clish CB, Kiessling LL, Hung DT. Genetic factors affecting storage and utilization of lipids during dormancy in . Mbio. e0320823. PMID 38236034 DOI: 10.1128/mbio.03208-23 |
0.798 |
|
| 2023 |
Ahmed S, Chowdhury S, Gomez J, Hung DT, Parish T. Benzene Amide Ether Scaffold is Active against Non-replicating and Intracellular . Acs Infectious Diseases. PMID 37708378 DOI: 10.1021/acsinfecdis.3c00275 |
0.627 |
|
| 2023 |
Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Salm EJ, Choi C, Combs S, Lee JSW, Rodriguez-Osorio C, Tomita S, Hung DT. A tryptophan metabolite modulates the host response to bacterial infection via kainate receptors. Biorxiv : the Preprint Server For Biology. PMID 37645903 DOI: 10.1101/2023.08.16.553532 |
0.746 |
|
| 2023 |
Thakku SG, Lirette J, Murugesan K, Chen J, Theron G, Banaei N, Blainey PC, Gomez J, Wong SY, Hung DT. Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13. Nature Communications. 14: 1803. PMID 37002219 DOI: 10.1038/s41467-023-37183-8 |
0.627 |
|
| 2023 |
Saebi A, Brown JS, Marando VM, Hartrampf N, Chumbler NM, Hanna S, Poskus M, Loas A, Kiessling LL, Hung DT, Pentelute BL. Rapid Single-Shot Synthesis of the 214 Amino Acid-Long N-Terminal Domain of Pyocin S2. Acs Chemical Biology. PMID 36821521 DOI: 10.1021/acschembio.2c00862 |
0.776 |
|
| 2023 |
Zhang S, Ma P, Orzechowski M, Lemmer A, Rzasa K, Bagnall J, Barkho S, Chen M, He L, Neitupski R, Tran V, Ackerman R, Gath E, Bond A, Frongillo G, ... ... Hung D, et al. High-Throughput Neutralization and Serology Assays Reveal Correlated but Highly Variable Humoral Immune Responses in a Large Population of Individuals Infected with SARS-CoV-2 in the US between March and August 2020. Mbio. e0352322. PMID 36786604 DOI: 10.1128/mbio.03523-22 |
0.782 |
|
| 2023 |
Ma P, Amemiya HM, He LL, Gandhi SJ, Nicol R, Bhattacharyya RP, Smillie CS, Hung DT. Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states. Cell. PMID 36708705 DOI: 10.1016/j.cell.2023.01.002 |
0.812 |
|
| 2022 |
Woolley AE, Dryden-Peterson S, Kim A, Naz-McLean S, Kelly C, Laibinis HH, Bagnall J, Livny J, Ma P, Orzechowski M, Gomez J, Shoresh N, Gabriel S, Hung DT, Cosimi LA. At-home Testing and Risk Factors for Acquisition of SARS-CoV-2 Infection in a Major US Metropolitan Area. Open Forum Infectious Diseases. 9: ofac505. PMID 36381614 DOI: 10.1093/ofid/ofac505 |
0.766 |
|
| 2022 |
Pita-Juarez Y, Karagkouni D, Kalavros N, Melms JC, Niezen S, Delorey TM, Essene AL, Brook OR, Pant D, Skelton-Badlani D, Naderi P, Huang P, Pan L, Hether T, Andrews TS, ... ... Hung D, et al. A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients. Biorxiv : the Preprint Server For Biology. PMID 36324805 DOI: 10.1101/2022.10.27.514070 |
0.768 |
|
| 2022 |
Parker EN, Cain BN, Hajian B, Ulrich RJ, Geddes EJ, Barkho S, Lee HY, Williams JD, Raynor M, Caridha D, Zaino A, Rohde JM, Zak M, Shekhar M, Muñoz KA, ... ... Hung DT, et al. Correction to "An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with Efficacy against Drug-Resistant Gram-Negative Infections". Acs Central Science. 8: 1362. PMID 36188352 DOI: 10.1021/acscentsci.2c00969 |
0.523 |
|
| 2022 |
Parker EN, Cain BN, Hajian B, Ulrich RJ, Geddes EJ, Barkho S, Lee HY, Williams JD, Raynor M, Caridha D, Zaino A, Shekhar M, Muñoz KA, Rzasa KM, Temple ER, ... ... Hung DT, et al. An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with Efficacy against Drug-Resistant Gram-Negative Infections. Acs Central Science. 8: 1145-1158. PMID 36032774 DOI: 10.1021/acscentsci.2c00598 |
0.599 |
|
| 2022 |
Warrier T, Romano KP, Clatworthy AE, Hung DT. Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation. Cell Chemical Biology. 29: 716-729. PMID 35523184 DOI: 10.1016/j.chembiol.2022.04.006 |
0.807 |
|
| 2022 |
Thakku SG, Ackerman CM, Myhrvold C, Bhattacharyya RP, Livny J, Ma P, Gomez GI, Sabeti PC, Blainey PC, Hung DT. Multiplexed detection of bacterial nucleic acids using Cas13 in droplet microarrays. Pnas Nexus. 1: pgac021. PMID 35450424 DOI: 10.1093/pnasnexus/pgac021 |
0.808 |
|
| 2022 |
Koh EI, Oluoch PO, Ruecker N, Proulx MK, Soni V, Murphy KC, Papavinasasundaram K, Reames CJ, Trujillo C, Zaveri A, Zimmerman MD, Aslebagh R, Baker RE, Shaffer SA, Guinn KM, ... ... Hung DT, et al. Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy. Proceedings of the National Academy of Sciences of the United States of America. 119: e2201632119. PMID 35380903 DOI: 10.1073/pnas.2201632119 |
0.397 |
|
| 2022 |
Woolley AE, Dryden-Peterson S, Kim A, Naz-McLean S, Kelly C, Laibinis HH, Bagnall J, Livny J, Ma P, Orzechowski M, Shoresh N, Gabriel S, Hung DT, Cosimi LA. At-home Testing and Risk Factors for Acquisition of SARS-CoV-2 Infection in a Major US Metropolitan Area. Medrxiv : the Preprint Server For Health Sciences. PMID 35132425 DOI: 10.1101/2022.02.02.22269258 |
0.702 |
|
| 2022 |
Poulsen BE, Clatworthy AE, Hung DT. The Use of Tn-Seq and the FiTnEss Analysis to Define the Core Essential Genome of Pseudomonas aeruginosa. Methods in Molecular Biology (Clifton, N.J.). 2377: 179-197. PMID 34709617 DOI: 10.1007/978-1-0716-1720-5_10 |
0.777 |
|
| 2021 |
Lennon NJ, Bhattacharyya RP, Mina MJ, Rehm HL, Hung DT, Smole S, Woolley A, Lander ES, Gabriel SB. Cross-sectional assessment of SARS-CoV-2 viral load by symptom status in Massachusetts congregate living facilities. The Journal of Infectious Diseases. PMID 34255846 DOI: 10.1093/infdis/jiab367 |
0.585 |
|
| 2021 |
Johnson EO, Hung DT. Using Proteolytic Hypomorphs to Detect Small Molecule Mechanism of Action. Methods in Molecular Biology (Clifton, N.J.). 2314: 323-342. PMID 34235661 DOI: 10.1007/978-1-0716-1460-0_15 |
0.787 |
|
| 2021 |
Di Germanio C, Simmons G, Kelly K, Martinelli R, Darst O, Azimpouran M, Stone M, Hazegh K, Grebe E, Zhang S, Ma P, Orzechowski M, Gomez JE, Livny J, Hung DT, et al. SARS-CoV-2 Antibody persistence in COVID-19 convalescent plasma donors: Dependency on assay format and applicability to serosurveillance. Transfusion. PMID 34121205 DOI: 10.1111/trf.16555 |
0.771 |
|
| 2021 |
Michalska K, Wellington S, Maltseva N, Jedrzejczak R, Selem-Mojica N, Rosas-Becerra LR, Barona-Gómez F, Hung DT, Joachimiak A. Catalytically impaired TrpA subunit of tryptophan synthase from Chlamydia trachomatis is an allosteric regulator of TrpB. Protein Science : a Publication of the Protein Society. PMID 34107106 DOI: 10.1002/pro.4143 |
0.782 |
|
| 2021 |
Reyes M, Filbin MR, Bhattacharyya RP, Sonny A, Mehta A, Billman K, Kays KR, Pinilla-Vera M, Benson ME, Cosimi LA, Hung DT, Levy BD, Villani AC, Sade-Feldman M, Baron RM, et al. Plasma from patients with bacterial sepsis or severe COVID-19 induces production of suppressive myeloid cells from human hematopoietic progenitor cells in vitro. Science Translational Medicine. PMID 34103408 DOI: 10.1126/scitranslmed.abe9599 |
0.638 |
|
| 2021 |
Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe Å, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, ... ... Hung D, et al. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature. PMID 33915569 DOI: 10.1038/s41586-021-03570-8 |
0.777 |
|
| 2021 |
Penaranda C, Chumbler NM, Hung DT. Dual transcriptional analysis reveals adaptation of host and pathogen to intracellular survival of Pseudomonas aeruginosa associated with urinary tract infection. Plos Pathogens. 17: e1009534. PMID 33901267 DOI: 10.1371/journal.ppat.1009534 |
0.815 |
|
| 2021 |
Ma P, He LL, Pironti A, Laibinis HH, Ernst CM, Manson AL, Bhattacharyya RP, Earl AM, Livny J, Hung D. Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics. Elife. 10. PMID 33871353 DOI: 10.7554/eLife.67310 |
0.799 |
|
| 2021 |
Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe A, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, ... ... Hung D, et al. A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 33655247 DOI: 10.1101/2021.02.25.430130 |
0.78 |
|
| 2020 |
Reyes M, Filbin MR, Bhattacharyya RP, Sonny A, Mehta A, Billman K, Kays KR, Pinilla-Vera M, Benson ME, Cosimi LA, Hung DT, Levy BD, Villani AC, Sade-Feldman M, Baron RM, et al. Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19. Biorxiv : the Preprint Server For Biology. PMID 32908980 DOI: 10.1101/2020.09.02.280180 |
0.643 |
|
| 2020 |
Ernst CM, Braxton JR, Rodriguez-Osorio CA, Zagieboylo AP, Li L, Pironti A, Manson AL, Nair AV, Benson M, Cummins K, Clatworthy AE, Earl AM, Cosimi LA, Hung DT. Author Correction: Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae. Nature Medicine. PMID 32587394 DOI: 10.1038/S41591-020-0974-5 |
0.723 |
|
| 2020 |
Ackerman CM, Myhrvold C, Thakku SG, Freije CA, Metsky HC, Yang DK, Ye SH, Boehm CK, Kosoko-Thoroddsen TF, Kehe J, Nguyen TG, Carter A, Kulesa A, Barnes JR, Dugan VG, ... Hung DT, et al. Massively multiplexed nucleic acid detection using Cas13. Nature. PMID 32349121 DOI: 10.1038/S41586-020-2279-8 |
0.322 |
|
| 2020 |
Ernst CM, Braxton JR, Rodriguez-Osorio CA, Zagieboylo AP, Li L, Pironti A, Manson AL, Nair AV, Benson M, Cummins K, Clatworthy AE, Earl AM, Cosimi LA, Hung DT. Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae. Nature Medicine. PMID 32284589 DOI: 10.1038/S41591-020-0825-4 |
0.76 |
|
| 2020 |
Reyes M, Filbin MR, Bhattacharyya RP, Billman K, Eisenhaure T, Hung DT, Levy BD, Baron RM, Blainey PC, Goldberg MB, Hacohen N. An immune-cell signature of bacterial sepsis. Nature Medicine. PMID 32066974 DOI: 10.1038/S41591-020-0752-4 |
0.686 |
|
| 2019 |
Betin V, Penaranda C, Bandyopadhyay N, Yang R, Abitua A, Bhattacharyya RP, Fan A, Avraham R, Livny J, Shoresh N, Hung DT. Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis. Scientific Reports. 9: 19244. PMID 31848386 DOI: 10.1038/S41598-019-55633-6 |
0.807 |
|
| 2019 |
Bhattacharyya RP, Bandyopadhyay N, Ma P, Son SS, Liu J, He LL, Wu L, Khafizov R, Boykin R, Cerqueira GC, Pironti A, Rudy RF, Patel MM, Yang R, Skerry J, ... ... Hung DT, et al. Simultaneous detection of genotype and phenotype enables rapid and accurate antibiotic susceptibility determination. Nature Medicine. PMID 31768064 DOI: 10.1038/S41591-019-0650-9 |
0.808 |
|
| 2019 |
Johnson EO, Office E, Kawate T, Orzechowski M, Hung DT. A large-scale chemical-genetic strategy enables design of antimicrobial combination chemotherapy in . Acs Infectious Diseases. PMID 31721551 DOI: 10.1021/Acsinfecdis.9B00373 |
0.79 |
|
| 2019 |
Johnson EO, Hung DT. A point of inflection and reflection on systems chemical biology. Acs Chemical Biology. PMID 31613592 DOI: 10.1021/Acschembio.9B00714 |
0.755 |
|
| 2019 |
Michalska K, Gale J, Joachimiak G, Chang C, Hatzos-Skintges C, Nocek B, Johnston SE, Bigelow L, Bajrami B, Jedrzejczak RP, Wellington S, Hung DT, Nag PP, Fisher SL, Endres M, et al. Conservation of the structure and function of bacterial tryptophan synthases. Iucrj. 6: 649-664. PMID 31316809 DOI: 10.1107/S2052252519005955 |
0.797 |
|
| 2019 |
Romano KP, Warrier T, Poulsen BE, Nguyen PH, Loftis AR, Saebi A, Pentelute BL, Hung DT. Mutations in confer cross-resistance between the LptD inhibitor POL7080 and colistin in . Antimicrobial Agents and Chemotherapy. PMID 31235628 DOI: 10.1128/Aac.00511-19 |
0.799 |
|
| 2019 |
Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, ... ... Hung DT, et al. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. PMID 31217586 DOI: 10.1038/S41586-019-1315-Z |
0.8 |
|
| 2019 |
Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, ... ... Hung DT, et al. Publisher Correction: Definitions and guidelines for research on antibiotic persistence. Nature Reviews. Microbiology. PMID 31036919 DOI: 10.1038/S41579-019-0207-4 |
0.511 |
|
| 2019 |
Poulsen BE, Yang R, Clatworthy AE, White T, Osmulski SJ, Li L, Penaranda C, Lander ES, Shoresh N, Hung DT. Defining the core essential genome of . Proceedings of the National Academy of Sciences of the United States of America. PMID 31036669 DOI: 10.1073/Pnas.1900570116 |
0.781 |
|
| 2019 |
Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, ... ... Hung DT, et al. Definitions and guidelines for research on antibiotic persistence. Nature Reviews. Microbiology. PMID 30980069 DOI: 10.1038/S41579-019-0196-3 |
0.559 |
|
| 2019 |
Bhattacharyya RP, Walker M, Boykin R, Son SS, Liu J, Hachey AC, Ma P, Wu L, Choi K, Cummins KC, Benson M, Skerry J, Ryu H, Wong SY, Goldberg MB, ... ... Hung DT, et al. Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA. Scientific Reports. 9: 4516. PMID 30872641 DOI: 10.1038/S41598-019-40792-3 |
0.807 |
|
| 2019 |
Penaranda C, Hung DT. Single-Cell RNA Sequencing to Understand Host-Pathogen Interactions. Acs Infectious Diseases. PMID 30702856 DOI: 10.1021/Acsinfecdis.8B00369 |
0.793 |
|
| 2019 |
Reyes M, Bhattacharyya RP, Filbin M, Billman K, Eisenhaure T, Hung DT, Levy B, Baron R, Blainey P, Goldberg MB, Hacohen N. 1830. Single-cell Transcriptional Profiling Reveals an Immune Cell State Signature of Bacterial Sepsis Open Forum Infectious Diseases. 6: S42-S42. DOI: 10.1093/Ofid/Ofz359.092 |
0.681 |
|
| 2018 |
Fang C, Lee KK, Nietupski R, Bates RH, Fernandez-Menendez R, Lopez-Roman EM, Guijarro-Lopez L, Yin Y, Peng Z, Gomez JE, Fisher S, Barros-Aguirre D, Hubbard BK, Serrano-Wu MH, Hung DT. Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 30316633 DOI: 10.1016/J.Bmcl.2018.09.037 |
0.637 |
|
| 2018 |
Parada-Kusz M, Penaranda C, Hagedorn EJ, Clatworthy A, Nair AV, Henninger JE, Ernst C, Li B, Riquelme R, Jijon H, Villablanca EJ, Zon LI, Hung D, Allende ML. Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Disease Models & Mechanisms. PMID 30266803 DOI: 10.1242/Dmm.034876 |
0.78 |
|
| 2018 |
Ma P, Laibinis HH, Ernst CM, Hung DT. Carbapenem resistance caused by high-level expression of OXA-663 β-lactamase in an OmpK36-deficient clinical isolate. Antimicrobial Agents and Chemotherapy. PMID 30126962 DOI: 10.1128/Aac.01281-18 |
0.741 |
|
| 2018 |
Bhattacharyya RP, Thakku SG, Hung DT. Harnessing CRISPR Effectors for Infectious Disease Diagnostics. Acs Infectious Diseases. PMID 30113801 DOI: 10.1021/Acsinfecdis.8B00170 |
0.675 |
|
| 2018 |
Clatworthy AE, Romano KP, Hung DT. Whole-organism phenotypic screening for anti-infectives promoting host health. Nature Chemical Biology. PMID 29556098 DOI: 10.1038/S41589-018-0018-3 |
0.816 |
|
| 2018 |
Wellington S, Hung DT. The expanding diversity of Mycobacterium tuberculosis drug targets. Acs Infectious Diseases. PMID 29412643 DOI: 10.1021/Acsinfecdis.7B00255 |
0.796 |
|
| 2017 |
Kim M, Wu L, Kim B, Hung DT, Han J. Continuous and High-Throughput Electromechanical Lysis of Bacterial Pathogens Using Ion Concentration Polarization. Analytical Chemistry. PMID 29193960 DOI: 10.1021/Acs.Analchem.7B03746 |
0.323 |
|
| 2017 |
Avital G, Avraham R, Fan A, Hashimshony T, Hung DT, Yanai I. scDual-Seq: mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing. Genome Biology. 18: 200. PMID 29073931 DOI: 10.1186/S13059-017-1340-X |
0.808 |
|
| 2017 |
Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, ... Hung DT, et al. A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nature Chemical Biology. PMID 28671682 DOI: 10.1038/Nchembio.2420 |
0.798 |
|
| 2017 |
Barczak AK, Avraham R, Singh S, Luo SS, Zhang WR, Bray MA, Hinman AE, Thompson M, Nietupski RM, Golas A, Montgomery P, Fitzgerald M, Smith RS, White DW, Tischler AD, ... ... Hung DT, et al. Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence. Plos Pathogens. 13: e1006363. PMID 28505176 DOI: 10.1371/Journal.Ppat.1006363 |
0.73 |
|
| 2017 |
Gootenberg JS, Abudayyeh OO, Lee JW, Essletzbichler P, Dy AJ, Joung J, Verdine V, Donghia N, Daringer NM, Freije CA, Myhrvold C, Bhattacharyya RP, Livny J, Regev A, Koonin EV, ... Hung DT, et al. Nucleic acid detection with CRISPR-Cas13a/C2c2. Science (New York, N.Y.). PMID 28408723 DOI: 10.1126/Science.Aam9321 |
0.671 |
|
| 2017 |
Gomez JE, Kaufmann-Malaga BB, Wivagg CN, Kim PB, Silvis MR, Renedo N, Ioerger TR, Ahmad R, Livny J, Fishbein S, Sacchettini JC, Carr SA, Hung DT. Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment. Elife. 6. PMID 28220755 DOI: 10.7554/Elife.20420 |
0.797 |
|
| 2017 |
Cerqueira GC, Earl AM, Ernst CM, Grad YH, Dekker JP, Feldgarden M, Chapman SB, Reis-Cunha JL, Shea TP, Young S, Zeng Q, Delaney ML, Kim D, Peterson EM, O'Brien TF, ... ... Hung DT, et al. Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096418 DOI: 10.1073/Pnas.1616248114 |
0.334 |
|
| 2017 |
Gomez JE, Kaufmann-Malaga BB, Wivagg CN, Kim PB, Silvis MR, Renedo N, Ioerger TR, Ahmad R, Livny J, Fishbein S, Sacchettini JC, Carr SA, Hung DT. Author response: Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment Elife. DOI: 10.7554/Elife.20420.025 |
0.638 |
|
| 2017 |
Michalska K, Wellington S, Nag PP, Jedrzejczak R, Maltseva NI, Fisher SL, Schreiber SL, Hung DT, Joachimiak A. Structure of Mycobacterium tuberculosis tryptophan synthase: a model system for allosteric inhibition Acta Crystallographica Section a Foundations and Advances. 73: a288-a288. DOI: 10.1107/S0108767317097161 |
0.775 |
|
| 2017 |
Joachimiak A, Wellington S, Nag PP, Jedrzejczak R, Maltseva NI, Fisher SL, Schreiber SL, Hung DT, Michalska K. Structural insight into allosteric inhibition of Mycobacterium tuberculosis tryptophan synthase Acta Crystallographica Section a Foundations and Advances. 73: a428-a428. DOI: 10.1107/S0108767317095824 |
0.778 |
|
| 2017 |
Bhattacharyya R, Liu J, Ma P, Bandyopadhyay N, Livny J, Hung D. Rapid Phenotypic Antibiotic Susceptibility Testing Through RNA Detection Open Forum Infectious Diseases. 4: S33-S33. DOI: 10.1093/Ofid/Ofx162.082 |
0.785 |
|
| 2016 |
Avraham R, Hung DT. A perspective on single cell behavior during infection. Gut Microbes. 0. PMID 27658058 DOI: 10.1080/19490976.2016.1239001 |
0.738 |
|
| 2016 |
Wivagg CN, Wellington S, Gomez JE, Hung DT. Loss of a Class A Penicillin-Binding Protein Alters β-Lactam Susceptibilities in Mycobacterium tuberculosis. Acs Infectious Diseases. 2: 104-10. PMID 27624961 DOI: 10.1021/Acsinfecdis.5B00119 |
0.789 |
|
| 2016 |
Zhang D, Gomez JE, Chien JY, Haseley N, Desjardins CA, Earl AM, Hsueh PR, Hung DT. Genomic analysis of the evolution of fluoroquinolone resistance in Mycobacterium tuberculosis prior to tuberculosis diagnosis. Antimicrobial Agents and Chemotherapy. PMID 27572408 DOI: 10.1128/Aac.00664-16 |
0.802 |
|
| 2016 |
Outterson K, Rex JH, Jinks T, Jackson P, Hallinan J, Karp S, Hung DT, Franceschi F, Merkeley T, Houchens C, Dixon DM, Kurilla MG, Aurigemma R, Larsen J. Accelerating global innovation to address antibacterial resistance: introducing CARB-X. Nature Reviews. Drug Discovery. PMID 27469032 DOI: 10.1038/Nrd.2016.155 |
0.309 |
|
| 2016 |
Avraham R, Haseley N, Fan A, Bloom-Ackermann Z, Livny J, Hung DT. A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes. Nature Protocols. 11: 1477-1491. PMID 27442864 DOI: 10.1038/Nprot.2016.090 |
0.791 |
|
| 2016 |
Grant SS, Wellington S, Kawate T, Desjardins CA, Silvis MR, Wivagg C, Thompson M, Gordon K, Kazyanskaya E, Nietupski R, Haseley N, Iwase N, Earl AM, Fitzgerald M, Hung DT. Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors. Cell Chemical Biology. PMID 27321573 DOI: 10.1016/J.Chembiol.2016.05.011 |
0.78 |
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| 2015 |
Avraham R, Haseley N, Brown D, Penaranda C, Jijon HB, Trombetta JJ, Satija R, Shalek AK, Xavier RJ, Regev A, Hung DT. Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses. Cell. 162: 1309-21. PMID 26343579 DOI: 10.1016/J.Cell.2015.08.027 |
0.804 |
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| 2015 |
Hou HW, Bhattacharyya RP, Hung DT, Han J. Direct detection and drug-resistance profiling of bacteremias using inertial microfluidics. Lab On a Chip. 15: 2297-307. PMID 25882432 DOI: 10.1039/C5Lc00311C |
0.709 |
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| 2015 |
Shishkin AA, Giannoukos G, Kucukural A, Ciulla D, Busby M, Surka C, Chen J, Bhattacharyya RP, Rudy RF, Patel MM, Novod N, Hung DT, Gnirke A, Garber M, Guttman M, et al. Simultaneous generation of many RNA-seq libraries in a single reaction. Nature Methods. 12: 323-5. PMID 25730492 DOI: 10.1038/Nmeth.3313 |
0.64 |
|
| 2015 |
Avraham R, Haseley N, Brown D, Penaranda C, Jijon HB, Trombetta JJ, Satija R, Shalek AK, Xavier RJ, Regev A, Hung DT. Erratum: Pathogen cell-to-cell variability drives heterogeneity in host immune responses ((Cell (2015) 162 (1309-1321)) Cell. 163. DOI: 10.1016/J.Cell.2015.09.044 |
0.784 |
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| 2014 |
Wivagg CN, Bhattacharyya RP, Hung DT. Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis. The Journal of Antibiotics. 67: 645-54. PMID 25052484 DOI: 10.1038/Ja.2014.94 |
0.801 |
|
| 2014 |
Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. Plos Pathogens. 10: e1003946. PMID 24586159 DOI: 10.1371/Journal.Ppat.1003946 |
0.552 |
|
| 2014 |
Slater LH, Clatworthy AE, Hung DT. Bacterial toxins and small molecules elucidate endosomal trafficking. Trends in Microbiology. 22: 53-5. PMID 24370463 DOI: 10.1016/J.Tim.2013.12.002 |
0.74 |
|
| 2013 |
Kawate T, Iwase N, Shimizu M, Stanley SA, Wellington S, Kazyanskaya E, Hung DT. Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32. Bioorganic & Medicinal Chemistry Letters. 23: 6052-9. PMID 24103299 DOI: 10.1016/J.Bmcl.2013.09.035 |
0.779 |
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| 2013 |
Grant SS, Kawate T, Nag PP, Silvis MR, Gordon K, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Fitzgerald M, Cho S, Franzblau SG, Hung DT. Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model. Acs Chemical Biology. 8: 2224-34. PMID 23898841 DOI: 10.1021/Cb4004817 |
0.379 |
|
| 2013 |
Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proceedings of the National Academy of Sciences of the United States of America. 110: 11565-70. PMID 23798446 DOI: 10.1073/Pnas.1302114110 |
0.787 |
|
| 2013 |
Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 9932-7. PMID 23716698 DOI: 10.1073/Pnas.1302257110 |
0.795 |
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| 2013 |
Wright GD, Hung DT, Helmann JD. How antibiotics kill bacteria: new models needed? Nature Medicine. 19: 544-5. PMID 23652106 DOI: 10.1038/Nm.3198 |
0.341 |
|
| 2013 |
Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nature Chemical Biology. 9: 398-405. PMID 23603659 DOI: 10.1038/Nchembio.1236 |
0.697 |
|
| 2013 |
Grant SS, Hung DT. Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response. Virulence. 4: 273-83. PMID 23563389 DOI: 10.4161/Viru.23987 |
0.405 |
|
| 2013 |
Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT. Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. Acs Chemical Biology. 8: 812-22. PMID 23343607 DOI: 10.1021/Cb300555N |
0.806 |
|
| 2012 |
Chand NS, Clatworthy AE, Hung DT. The two-component sensor KinB acts as a phosphatase to regulate Pseudomonas aeruginosa Virulence. Journal of Bacteriology. 194: 6537-47. PMID 23024348 DOI: 10.1128/Jb.01168-12 |
0.78 |
|
| 2012 |
McMahon TC, Stanley S, Kazyanskaya E, Hung D, Wood JL. The first synthesis of an epidiselenodiketopiperazine. Organic Letters. 14: 4534-6. PMID 22913407 DOI: 10.1021/Ol3020094 |
0.481 |
|
| 2012 |
Grant SS, Kaufmann BB, Chand NS, Haseley N, Hung DT. Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals. Proceedings of the National Academy of Sciences of the United States of America. 109: 12147-52. PMID 22778419 DOI: 10.1073/Pnas.1203735109 |
0.794 |
|
| 2012 |
Stanley SA, Grant SS, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. Acs Chemical Biology. 7: 1377-84. PMID 22577943 DOI: 10.1021/Cb300151M |
0.805 |
|
| 2012 |
Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT. RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proceedings of the National Academy of Sciences of the United States of America. 109: 6217-22. PMID 22474362 DOI: 10.1073/Pnas.1119540109 |
0.694 |
|
| 2012 |
Weiner B, Gomez J, Victor TC, Warren RM, Sloutsky A, Plikaytis BB, Posey JE, van Helden PD, Gey van Pittius NC, Koehrsen M, Sisk P, Stolte C, White J, Gagneux S, Birren B, ... Hung D, et al. Independent large scale duplications in multiple M. tuberculosis lineages overlapping the same genomic region. Plos One. 7: e26038. PMID 22347359 DOI: 10.1371/Journal.Pone.0026038 |
0.649 |
|
| 2012 |
Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, Fitzgerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, Sykes S, Walker BJ, Wortman JR, Young S, Zeng Q, ... ... Hung DT, et al. Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011. Proceedings of the National Academy of Sciences of the United States of America. 109: 3065-70. PMID 22315421 DOI: 10.1073/Pnas.1121491109 |
0.314 |
|
| 2012 |
Wivagg CN, Hung DT. Resuscitation-promoting factors are required for β-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 56: 1591-4. PMID 22155826 DOI: 10.1128/Aac.06027-11 |
0.792 |
|
| 2011 |
Chand NS, Hung DT. The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection. Virulence. 2: 553-8. PMID 21971182 DOI: 10.4161/Viru.2.6.17987 |
0.79 |
|
| 2011 |
Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR. GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro. Molecular Microbiology. 81: 1390-401. PMID 21797942 DOI: 10.1111/J.1365-2958.2011.07770.X |
0.326 |
|
| 2011 |
Chand NS, Lee JS, Clatworthy AE, Golas AJ, Smith RS, Hung DT. The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection. Journal of Bacteriology. 193: 2989-99. PMID 21515773 DOI: 10.1128/Jb.01546-10 |
0.779 |
|
| 2011 |
Gomez JE, Clatworthy A, Hung DT. Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches. Critical Reviews in Biochemistry and Molecular Biology. 46: 41-66. PMID 21250782 DOI: 10.3109/10409238.2010.538663 |
0.795 |
|
| 2011 |
McMahon TC, Stanley S, Kazyanskaya E, Hung D, Wood JL. A scaleable formal total synthesis of dehydrogliotoxin Tetrahedron Letters. 52: 2262-2264. DOI: 10.1016/J.Tetlet.2011.01.138 |
0.437 |
|
| 2010 |
Kaufmann BB, Hung DT. The fast track to multidrug resistance. Molecular Cell. 37: 297-8. PMID 20159549 DOI: 10.1016/J.Molcel.2010.01.027 |
0.337 |
|
| 2010 |
NERENBERG JB, HUNG DT, SOMERS PK, SCHREIBER SL. ChemInform Abstract: Total Synthesis of the Immunosuppressive Agent (-)-Discodermolide. Cheminform. 25: no-no. DOI: 10.1002/chin.199415284 |
0.32 |
|
| 2009 |
Stanley SA, Hung DT. Toward a systems-level analysis of infection biology: a new method for conducting genetic screens in human cells. Science Translational Medicine. 1: 11ps13. PMID 20371455 DOI: 10.1126/Scitranslmed.3000550 |
0.342 |
|
| 2009 |
Hett EC, Hung DT. Targeting multiple biofilm pathways. Chemistry & Biology. 16: 1216-8. PMID 20064430 DOI: 10.1016/J.Chembiol.2009.12.003 |
0.725 |
|
| 2009 |
Stanley SA, Hung DT. Chemical tools for dissecting bacterial physiology and virulence. Biochemistry. 48: 8776-86. PMID 19653697 DOI: 10.1021/Bi9009083 |
0.44 |
|
| 2009 |
Barczak AK, Hung DT. Productive steps toward an antimicrobial targeting virulence. Current Opinion in Microbiology. 12: 490-6. PMID 19631578 DOI: 10.1016/J.Mib.2009.06.012 |
0.41 |
|
| 2009 |
Clatworthy AE, Lee JS, Leibman M, Kostun Z, Davidson AJ, Hung DT. Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants. Infection and Immunity. 77: 1293-303. PMID 19168742 DOI: 10.1128/Iai.01181-08 |
0.759 |
|
| 2009 |
Nusbaum C, Ohsumi TK, Gomez J, Aquadro J, Victor TC, Warren RM, Hung DT, Birren BW, Lander ES, Jaffe DB. Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencing. Nature Methods. 6: 67-9. PMID 19079253 DOI: 10.1038/Nmeth.1286 |
0.645 |
|
| 2007 |
Clatworthy AE, Pierson E, Hung DT. Targeting virulence: A new paradigm for antimicrobial therapy Nature Chemical Biology. 3: 541-548. PMID 17710100 DOI: 10.1038/Nchembio.2007.24 |
0.764 |
|
| 2007 |
Shakhnovich EA, Hung DT, Pierson E, Lee K, Mekalanos JJ. Virstatin inhibits dimerization of the transcriptional activator ToxT Proceedings of the National Academy of Sciences of the United States of America. 104: 2372-2377. PMID 17283330 DOI: 10.1073/Pnas.0611643104 |
0.804 |
|
| 2006 |
Hung DT, Rubin EJ. Chemical biology and bacteria: not simply a matter of life or death. Current Opinion in Chemical Biology. 10: 321-6. PMID 16814591 DOI: 10.1016/J.Cbpa.2006.06.016 |
0.493 |
|
| 2006 |
Hung DT, Zhu J, Sturtevant D, Mekalanos JJ. Bile acids stimulate biofilm formation in Vibrio cholerae. Molecular Microbiology. 59: 193-201. PMID 16359328 DOI: 10.1111/J.1365-2958.2005.04846.X |
0.567 |
|
| 2005 |
Hung DT, Shakhnovich EA, Pierson E, Mekalanos JJ. Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. Science (New York, N.Y.). 310: 670-4. PMID 16223984 DOI: 10.1126/Science.1116739 |
0.807 |
|
| 2005 |
Hung DT, Mekalanos JJ. Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner. Proceedings of the National Academy of Sciences of the United States of America. 102: 3028-33. PMID 15699331 DOI: 10.1073/Pnas.0409559102 |
0.521 |
|
| 2002 |
Hung DT, Baden LR. A new era for sepsis treatment? Understanding sepsis as a consequence of host immune response Expert Opinion On Therapeutic Patents. 12: 181-192. DOI: 10.1517/13543776.12.2.181 |
0.338 |
|
| 1998 |
Hung DT, Nerenberg JB, Schreiber SL. Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides. Chemistry & Biology. 1: 67-71. PMID 9383372 DOI: 10.1016/1074-5521(94)90042-6 |
0.456 |
|
| 1997 |
Hung DT, Chen J, Schreiber SL. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chemistry & Biology. 3: 287-93. PMID 8807856 DOI: 10.1016/S1074-5521(96)90108-8 |
0.444 |
|
| 1996 |
Hung DT, Jamison TF, Schreiber SL. Understanding and controlling the cell cycle with natural products. Chemistry & Biology. 3: 623-39. PMID 8807895 DOI: 10.1016/S1074-5521(96)90129-5 |
0.614 |
|
| 1996 |
Hung DT, Nerenberg JB, Schreiber SL. Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization Journal of the American Chemical Society. 118: 11054-11080. DOI: 10.1021/Ja961374O |
0.448 |
|
| 1996 |
Liang J, Hung DT, Schreiber SL, Clardy J. Structure of the Human 25 kDa FK506 Binding Protein Complexed with Rapamycin Journal of the American Chemical Society. 118: 1231-1232. DOI: 10.1021/Ja953139W |
0.404 |
|
| 1993 |
Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR. Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Molecular and Cellular Biology. 13: 4760-9. PMID 7687744 DOI: 10.1128/Mcb.13.8.4760 |
0.461 |
|
| 1993 |
Nerenberg JB, Hung DT, Somers PK, Schreiber SL. Total synthesis of the immunosuppressive agent (-)-discodermolide Journal of the American Chemical Society. 115: 12621-12622. DOI: 10.1021/Ja00079A066 |
0.41 |
|
| 1992 |
Hung DT, Schreiber SL. cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. Biochemical and Biophysical Research Communications. 184: 733-8. PMID 1374240 DOI: 10.1016/0006-291X(92)90651-Z |
0.414 |
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