| Year |
Citation |
Score |
| 2020 |
Cal-Kayitmazbatir S, Kulkoyluoglu-Cotul E, Growe J, Selby CP, Rhoades SD, Malik D, Oner H, Asimgil H, Francey LJ, Sancar A, Kruger WD, Hogenesch JB, Weljie A, Anafi RC, Kavakli IH. CRY1-CBS binding regulates circadian clock function and metabolism. The Febs Journal. PMID 32383312 DOI: 10.1111/Febs.15360 |
0.336 |
|
| 2019 |
Gupta S, Gallego-Villar L, Wang L, Lee HO, Nasrallah G, Al-Dewik N, Häberle J, Thöny B, Blom HJ, Ben-Omran T, Kruger WD. Analysis of the Qatari R336C Cystathionine β-Synthase Protein in Mice. Journal of Inherited Metabolic Disease. PMID 31240737 DOI: 10.1002/Jimd.12140 |
0.412 |
|
| 2019 |
Lee HO, Gallego-Villar L, Grisch-Chan HM, Haeberle J, Thöny B, Kruger W. Treatment of CBS deficiency in mice using a minicircle-based naked DNA vector. Human Gene Therapy. PMID 31084364 DOI: 10.1089/Hum.2019.014 |
0.366 |
|
| 2018 |
Ismail HM, Krishnamoorthy N, Al-Dewik N, Zayed H, Mohamed NA, Giacomo VD, Gupta S, Häberle J, Thöny B, Blom HJ, Kruger WD, Ben-Omran T, Nasrallah GK. In silico and in vivo models for Qatari-Specific classical homocystinuria as basis for development of novel therapies. Human Mutation. PMID 30408270 DOI: 10.1002/Humu.23682 |
0.338 |
|
| 2018 |
Gupta S, Kelow S, Wang L, Andrake M, Dunbrack RL, Kruger WD. Mouse modeling and structural analysis of the p.G307S mutation in human cystathionine β-synthase () reveal effects on CBS activity but not stability. The Journal of Biological Chemistry. PMID 30030379 DOI: 10.1074/Jbc.Ra118.002164 |
0.409 |
|
| 2018 |
Lee HO, Wang L, Kuo YM, Andrews AJ, Gupta S, Kruger WD. S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice. Molecular Genetics and Metabolism Reports. 15: 15-21. PMID 30023284 DOI: 10.1016/J.Ymgmr.2018.01.002 |
0.381 |
|
| 2018 |
Tang B, Lee HO, An SS, Cai KQ, Kruger WD. Specific targeting of MTAP-deleted tumors with a combination of 2'-fluoroadenine and 5'-methylthioadenosine. Cancer Research. PMID 29844120 DOI: 10.1158/0008-5472.Can-18-0814 |
0.327 |
|
| 2017 |
Majtan T, Jones W, Krijt J, Park I, Kruger WD, Kožich V, Bassnett S, Bublil EM, Kraus JP. Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29398487 DOI: 10.1016/J.Ymthe.2017.12.014 |
0.347 |
|
| 2017 |
Gallego-Villar L, Hannibal L, Häberle J, Thöny B, Ben-Omran T, Nasrallah GK, Dewik AN, Kruger WD, Blom HJ. Cysteamine revisited: repair of arginine to cysteine mutations. Journal of Inherited Metabolic Disease. PMID 28643139 DOI: 10.1007/S10545-017-0060-4 |
0.357 |
|
| 2017 |
Kruger WD. Cystathionine β-synthase deficiency: Of mice and men. Molecular Genetics and Metabolism. PMID 28583326 DOI: 10.1016/J.Ymgme.2017.05.011 |
0.367 |
|
| 2017 |
Gupta S, Wang L, Kruger WD. The c.797 G>A (p.R266K) cystathionine β-Synthase mutation causes Homocystinuria by affecting protein stability. Human Mutation. PMID 28488385 DOI: 10.1002/Humu.23240 |
0.441 |
|
| 2017 |
Khayati K, Antikainen H, Bonder EM, Weber GF, Kruger WD, Jakubowski H, Dobrowolski R. The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 31: 598-609. PMID 28148781 DOI: 10.1096/Fj.201600915R |
0.341 |
|
| 2016 |
Li JG, Barrero C, Gupta S, Kruger WD, Merali S, Praticò D. Homocysteine modulates 5-lipoxygenase expression level via DNA methylation. Aging Cell. PMID 27896923 DOI: 10.1111/Acel.12550 |
0.348 |
|
| 2016 |
Lee HO, Wang L, Kuo YM, Gupta S, Slifker MJ, Li YS, Andrews AJ, Kruger WD. Lack of global epigenetic methylation defects in CBS deficient mice. Journal of Inherited Metabolic Disease. PMID 27444757 DOI: 10.1007/S10545-016-9958-5 |
0.349 |
|
| 2015 |
Kruger WD, Gupta S. The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice. Annals of the New York Academy of Sciences. PMID 26599618 DOI: 10.1111/Nyas.12967 |
0.39 |
|
| 2015 |
Gupta S, Wang L, Kruger WD. Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice. Journal of Inherited Metabolic Disease. PMID 26231230 DOI: 10.1007/S10545-015-9883-Z |
0.345 |
|
| 2015 |
Imbard A, Benoist JF, Esse R, Gupta S, Lebon S, de Vriese AS, de Baulny HO, Kruger W, Schiff M, Blom HJ. High homocysteine induces betaine depletion. Bioscience Reports. 35. PMID 26182429 DOI: 10.1042/Bsr20150094 |
0.322 |
|
| 2015 |
Gupta S, Kruger WD. Abstract 4785: Deficiency of cystathionine beta synthase gene does not affect tumor formation and survival of Eμ-myc mice Cancer Research. 75: 4785-4785. DOI: 10.1158/1538-7445.Am2015-4785 |
0.329 |
|
| 2014 |
Tang B, Kadariya Y, Chen Y, Slifker M, Kruger WD. Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function. G3 (Bethesda, Md.). 5: 35-44. PMID 25387827 DOI: 10.1534/G3.114.014555 |
0.341 |
|
| 2014 |
Fang P, Zhang D, Cheng Z, Yan C, Jiang X, Kruger WD, Meng S, Arning E, Bottiglieri T, Choi ET, Han Y, Yang XF, Wang H. Hyperhomocysteinemia potentiates hyperglycemia-induced inflammatory monocyte differentiation and atherosclerosis. Diabetes. 63: 4275-90. PMID 25008174 DOI: 10.2337/Db14-0809 |
0.33 |
|
| 2014 |
Esse R, Imbard A, Florindo C, Gupta S, Quinlivan EP, Davids M, Teerlink T, Tavares de Almeida I, Kruger WD, Blom HJ, Castro R. Protein arginine hypomethylation in a mouse model of cystathionine β-synthase deficiency. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2686-95. PMID 24532665 DOI: 10.1096/Fj.13-246579 |
0.354 |
|
| 2014 |
Gupta S, Melnyk SB, Kruger WD. Cystathionine β-synthase-deficient mice thrive on a low-methionine diet. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 781-90. PMID 24189943 DOI: 10.1096/Fj.13-240770 |
0.319 |
|
| 2013 |
Kadariya Y, Tang B, Wang L, Al-Saleem T, Hayakawa K, Slifker MJ, Kruger WD. Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice. Plos One. 8: e67635. PMID 23840755 DOI: 10.1371/Journal.Pone.0067635 |
0.408 |
|
| 2013 |
Gupta S, Wang L, Anderl J, Slifker MJ, Kirk C, Kruger WD. Correction of cystathionine β-synthase deficiency in mice by treatment with proteasome inhibitors. Human Mutation. 34: 1085-93. PMID 23592311 DOI: 10.1002/Humu.22335 |
0.436 |
|
| 2012 |
Zitserman D, Gupta S, Kruger WD, Karbowniczek M, Roegiers F. The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis. Plos One. 7: e48720. PMID 23144943 DOI: 10.1371/Journal.Pone.0048720 |
0.36 |
|
| 2012 |
Tang B, Testa JR, Kruger WD. Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells. Cancer Biology & Therapy. 13: 1082-90. PMID 22825330 DOI: 10.4161/Cbt.21115 |
0.324 |
|
| 2012 |
Régnier V, Billard JM, Gupta S, Potier B, Woerner S, Paly E, Ledru A, David S, Luilier S, Bizot JC, Vacano G, Kraus JP, Patterson D, Kruger WD, Delabar JM, et al. Brain phenotype of transgenic mice overexpressing cystathionine β-synthase. Plos One. 7: e29056. PMID 22253703 DOI: 10.1371/Journal.Pone.0029056 |
0.356 |
|
| 2012 |
Dayal S, Chauhan AK, Jensen M, Leo L, Lynch CM, Faraci FM, Kruger WD, Lentz SR. Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia. Blood. 119: 3176-83. PMID 22186991 DOI: 10.1182/Blood-2011-09-380568 |
0.306 |
|
| 2012 |
Kruger WD, Kadariya Y, Tang B, Al-Saleem T, Haykawa K. Abstract 2173: Heterozygosity for Mtap accelerates lymphomagenesis in Emu-Myc and Pten +/− mice Cancer Research. 72: 2173-2173. DOI: 10.1158/1538-7445.Am2012-2173 |
0.373 |
|
| 2011 |
Gupta S, Kruger WD. Cystathionine beta-synthase deficiency causes fat loss in mice. Plos One. 6: e27598. PMID 22096601 DOI: 10.1371/Journal.Pone.0027598 |
0.339 |
|
| 2011 |
Cheng Z, Jiang X, Kruger WD, Praticò D, Gupta S, Mallilankaraman K, Madesh M, Schafer AI, Durante W, Yang X, Wang H. Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice. Blood. 118: 1998-2006. PMID 21653942 DOI: 10.1182/Blood-2011-01-333310 |
0.304 |
|
| 2011 |
Knock E, Deng L, Krupenko N, Mohan RD, Wu Q, Leclerc D, Gupta S, Elmore CL, Kruger W, Tini M, Rozen R. Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair. The Journal of Nutritional Biochemistry. 22: 1022-9. PMID 21193302 DOI: 10.1016/J.Jnutbio.2010.07.015 |
0.35 |
|
| 2010 |
Strakova J, Williams KT, Gupta S, Schalinske KL, Kruger WD, Rozen R, Jiracek J, Li L, Garrow TA. Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats. Nutrition Research (New York, N.Y.). 30: 492-500. PMID 20797482 DOI: 10.1016/J.Nutres.2010.06.017 |
0.333 |
|
| 2010 |
Wei Q, Wang L, Wang Q, Kruger WD, Dunbrack RL. Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase. Proteins. 78: 2058-74. PMID 20455263 DOI: 10.1002/Prot.22722 |
0.361 |
|
| 2010 |
Zhuo JM, Kruger WD, Praticò D. The Herp protein pathway is not involved in the pro-amyloidogenic effect of hyperhomocysteinemia. Journal of Alzheimer's Disease : Jad. 20: 569-76. PMID 20164556 DOI: 10.3233/Jad-2010-1394 |
0.353 |
|
| 2010 |
Singh LR, Gupta S, Honig NH, Kraus JP, Kruger WD. Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70. Plos Genetics. 6: e1000807. PMID 20066033 DOI: 10.1371/Journal.Pgen.1000807 |
0.393 |
|
| 2010 |
Tang B, Mustafa A, Gupta S, Melnyk S, James SJ, Kruger WD. Methionine-deficient diet induces post-transcriptional downregulation of cystathionine β-synthase. Nutrition (Burbank, Los Angeles County, Calif.). 26: 1170-5. PMID 20036517 DOI: 10.1016/J.Nut.2009.10.006 |
0.399 |
|
| 2009 |
Kadariya Y, Yin B, Tang B, Shinton SA, Quinlivan EP, Hua X, Klein-Szanto A, Al-Saleem TI, Bassing CH, Hardy RR, Kruger WD. Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma. Cancer Research. 69: 5961-9. PMID 19567676 DOI: 10.1158/0008-5472.Can-09-0145 |
0.402 |
|
| 2009 |
Jakubowski H, Perla-Kaján J, Finnell RH, Cabrera RM, Wang H, Gupta S, Kruger WD, Kraus JP, Shih DM. Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 1721-7. PMID 19204075 DOI: 10.1096/Fj.08-127548 |
0.329 |
|
| 2009 |
Singh LR, Kruger WD. Functional rescue of mutant human cystathionine beta-synthase by manipulation of Hsp26 and Hsp70 levels in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 284: 4238-45. PMID 19074437 DOI: 10.1074/Jbc.M806387200 |
0.336 |
|
| 2009 |
Gupta S, Kühnisch J, Mustafa A, Lhotak S, Schlachterman A, Slifker MJ, Klein-Szanto A, High KA, Austin RC, Kruger WD. Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 883-93. PMID 18987302 DOI: 10.1096/Fj.08-120584 |
0.367 |
|
| 2008 |
Majtan T, Singh LR, Wang L, Kruger WD, Kraus JP. Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone. The Journal of Biological Chemistry. 283: 34588-95. PMID 18849566 DOI: 10.1074/Jbc.M805928200 |
0.333 |
|
| 2008 |
Roy M, Leclerc D, Wu Q, Gupta S, Kruger WD, Rozen R. Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency. Journal of Cellular Biochemistry. 105: 467-76. PMID 18615588 DOI: 10.1002/Jcb.21847 |
0.37 |
|
| 2008 |
Gupta S, Wang L, Hua X, Krijt J, Kozich V, Kruger WD. Cystathionine beta-synthase p.S466L mutation causes hyperhomocysteinemia in mice. Human Mutation. 29: 1048-54. PMID 18454451 DOI: 10.1002/Humu.20773 |
0.419 |
|
| 2007 |
van Slegtenhorst M, Khabibullin D, Hartman TR, Nicolas E, Kruger WD, Henske EP. The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe. The Journal of Biological Chemistry. 282: 24583-90. PMID 17556368 DOI: 10.1074/Jbc.M700857200 |
0.393 |
|
| 2007 |
Singh LR, Chen X, Kozich V, Kruger WD. Chemical chaperone rescue of mutant human cystathionine beta-synthase. Molecular Genetics and Metabolism. 91: 335-42. PMID 17540596 DOI: 10.1016/J.Ymgme.2007.04.011 |
0.402 |
|
| 2006 |
Chen X, Wang L, Fazlieva R, Kruger WD. Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response. Human Mutation. 27: 474-82. PMID 16619244 DOI: 10.1002/Humu.20320 |
0.361 |
|
| 2005 |
Wang L, Chen X, Tang B, Hua X, Klein-Szanto A, Kruger WD. Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Human Molecular Genetics. 14: 2201-8. PMID 15972722 DOI: 10.1093/Hmg/Ddi224 |
0.409 |
|
| 2005 |
Jhee KH, Kruger WD. The role of cystathionine beta-synthase in homocysteine metabolism. Antioxidants & Redox Signaling. 7: 813-22. PMID 15890029 DOI: 10.1089/Ars.2005.7.813 |
0.332 |
|
| 2005 |
Kadariya Y, Nakatani K, Nishioka J, Fujikawa T, Kruger WD, Nobori T. Regulation of human methylthioadenosine phosphorylase gene by the CBF (CCAAT binding factor)/NF-Y (nuclear factor-Y). The Biochemical Journal. 387: 175-83. PMID 15535799 DOI: 10.1042/Bj20041472 |
0.351 |
|
| 2004 |
Subhi AL, Tang B, Balsara BR, Altomare DA, Testa JR, Cooper HS, Hoffman JP, Meropol NJ, Kruger WD. Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 7290-6. PMID 15534104 DOI: 10.1158/1078-0432.Ccr-04-0972 |
0.321 |
|
| 2004 |
Wang L, Jhee KH, Hua X, DiBello PM, Jacobsen DW, Kruger WD. Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice. Circulation Research. 94: 1318-24. PMID 15105297 DOI: 10.1161/01.Res.0000129182.46440.4A |
0.367 |
|
| 2004 |
van Slegtenhorst M, Carr E, Stoyanova R, Kruger WD, Henske EP. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. The Journal of Biological Chemistry. 279: 12706-13. PMID 14718525 DOI: 10.1074/Jbc.M313874200 |
0.417 |
|
| 2004 |
Oh H, Park E, Kruger W, Jung S, Lee J. 181. Human CBS (Cystathionine |[beta]|-Synthase) Gene Transfer Mediated by Recombinant Adeno-Associated Virus Vector Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.141 |
0.416 |
|
| 2003 |
Kruger WD, Wang L, Jhee KH, Singh RH, Elsas LJ. Cystathionine beta-synthase deficiency in Georgia (USA): correlation of clinical and biochemical phenotype with genotype. Human Mutation. 22: 434-41. PMID 14635102 DOI: 10.1002/Humu.10290 |
0.364 |
|
| 2003 |
Subhi AL, Diegelman P, Porter CW, Tang B, Lu ZJ, Markham GD, Kruger WD. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. The Journal of Biological Chemistry. 278: 49868-73. PMID 14506228 DOI: 10.1074/Jbc.M308451200 |
0.407 |
|
| 2002 |
Christopher SA, Melnyk S, James SJ, Kruger WD. S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine beta-synthase. Molecular Genetics and Metabolism. 75: 335-43. PMID 12051965 DOI: 10.1016/S1096-7192(02)00003-3 |
0.356 |
|
| 2001 |
Shan X, Dunbrack RL, Christopher SA, Kruger WD. Mutations in the regulatory domain of cystathionine beta synthase can functionally suppress patient-derived mutations in cis. Human Molecular Genetics. 10: 635-43. PMID 11230183 DOI: 10.1093/Hmg/10.6.635 |
0.381 |
|
| 2001 |
Strizheva GD, Carsillo T, Kruger WD, Sullivan EJ, Ryu JH, Henske EP. The spectrum of mutations in TSC1 and TSC2 in women with tuberous sclerosis and lymphangiomyomatosis. American Journal of Respiratory and Critical Care Medicine. 163: 253-8. PMID 11208653 DOI: 10.1164/Ajrccm.163.1.2005004 |
0.325 |
|
| 2000 |
Kruger WD, Evans AA, Wang L, Malinow MR, Duell PB, Anderson PH, Block PC, Hess DL, Graf EE, Upson B. Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid. Molecular Genetics and Metabolism. 70: 53-60. PMID 10833331 DOI: 10.1006/Mgme.2000.2993 |
0.313 |
|
| 1999 |
Shan X, Wang L, Hoffmaster R, Kruger WD. Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 274: 32613-8. PMID 10551815 DOI: 10.1074/Jbc.274.46.32613 |
0.42 |
|
| 1999 |
Chen P, Poddar R, Tipa EV, Dibello PM, Moravec CD, Robinson K, Green R, Kruger WD, Garrow TA, Jacobsen DW. Homocysteine metabolism in cardiovascular cells and tissues: implications for hyperhomocysteinemia and cardiovascular disease. Advances in Enzyme Regulation. 39: 93-109. PMID 10470368 DOI: 10.1016/S0065-2571(98)00029-6 |
0.311 |
|
| 1999 |
Kraus JP, Janosík M, Kozich V, Mandell R, Shih V, Sperandeo MP, Sebastio G, de Franchis R, Andria G, Kluijtmans LA, Blom H, Boers GH, Gordon RB, Kamoun P, Tsai MY, ... Kruger WD, et al. Cystathionine beta-synthase mutations in homocystinuria. Human Mutation. 13: 362-75. PMID 10338090 DOI: 10.1002/(Sici)1098-1004(1999)13:5<362::Aid-Humu4>3.0.Co;2-K |
0.375 |
|
| 1998 |
Taoka S, Ohja S, Shan X, Kruger WD, Banerjee R. Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity. The Journal of Biological Chemistry. 273: 25179-84. PMID 9737978 DOI: 10.1074/Jbc.273.39.25179 |
0.309 |
|
| 1998 |
Shan X, Kruger WD. Correction of disease-causing CBS mutations in yeast. Nature Genetics. 19: 91-3. PMID 9590298 DOI: 10.1038/Ng0598-91 |
0.408 |
|
| 1997 |
Kim CE, Gallagher PM, Guttormsen AB, Refsum H, Ueland PM, Ose L, Folling I, Whitehead AS, Tsai MY, Kruger WD. Functional modeling of vitamin responsiveness in yeast: a common pyridoxine-responsive cystathionine beta-synthase mutation in homocystinuria. Human Molecular Genetics. 6: 2213-21. PMID 9361025 DOI: 10.1093/Hmg/6.13.2213 |
0.377 |
|
| 1996 |
Gulati S, Baker P, Li YN, Fowler B, Kruger W, Brody LC, Banerjee R. Defects in human methionine synthase in cblG patients. Human Molecular Genetics. 5: 1859-65. PMID 8968736 DOI: 10.1093/Hmg/5.12.1859 |
0.403 |
|
| 1996 |
Li YN, Gulati S, Baker PJ, Brody LC, Banerjee R, Kruger WD. Cloning, mapping and RNA analysis of the human methionine synthase gene. Human Molecular Genetics. 5: 1851-8. PMID 8968735 DOI: 10.1093/Hmg/5.12.1851 |
0.344 |
|
| 1995 |
Kruger W, Peterson CL, Sil A, Coburn C, Arents G, Moudrianakis EN, Herskowitz I. Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription. Genes & Development. 9: 2770-9. PMID 7590252 DOI: 10.1101/Gad.9.22.2770 |
0.692 |
|
| 1992 |
Herskowitz I, Andrews B, Kruger W, Ogas J, Sil A, Coburn C, Peterson C. 36 Integration of Multiple Regulatory Inputs in the Control of HO Expression in Yeast Cold Spring Harbor Monograph Archive. 949-974. DOI: 10.1101/087969425.22B.949 |
0.706 |
|
| 1991 |
Kruger W, Herskowitz I. A negative regulator of HO transcription, SIN1 (SPT2), is a nonspecific DNA-binding protein related to HMG1. Molecular and Cellular Biology. 11: 4135-46. PMID 2072912 DOI: 10.1128/Mcb.11.8.4135 |
0.61 |
|
| 1991 |
Peterson CL, Kruger W, Herskowitz I. A functional interaction between the C-terminal domain of RNA polymerase II and the negative regulator SIN1. Cell. 64: 1135-43. PMID 2004420 DOI: 10.1016/0092-8674(91)90268-4 |
0.641 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 1995 |
Kruger WD, Cox DR. A yeast assay for functional detection of mutations in the human cystathionine beta-synthase gene. Human Molecular Genetics. 4: 1155-61. PMID 8528202 DOI: 10.1093/hmg/4.7.1155 |
0.296 |
|
| 2004 |
Singh RH, Kruger WD, Wang L, Pasquali M, Elsas LJ. Cystathionine beta-synthase deficiency: effects of betaine supplementation after methionine restriction in B6-nonresponsive homocystinuria. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 6: 90-5. PMID 15017331 DOI: 10.1097/01.Gim.0000117334.84388.F4 |
0.295 |
|
| 2014 |
Shlomi T, Fan J, Tang B, Kruger WD, Rabinowitz JD. Quantitation of cellular metabolic fluxes of methionine. Analytical Chemistry. 86: 1583-91. PMID 24397525 DOI: 10.1021/Ac4032093 |
0.295 |
|
| 2020 |
Gu SX, Sonkar VK, Katare PB, Kumar R, Kruger WD, Arning E, Bottiglieri T, Lentz SR, Dayal S. Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia. Journal of the American Heart Association. 9: e013368. PMID 32067580 DOI: 10.1161/Jaha.119.013368 |
0.295 |
|
| 2000 |
Kruger WD. Vitamins and homocysteine metabolism. Vitamins and Hormones. 60: 333-52. PMID 11037628 DOI: 10.1016/S0083-6729(00)60023-7 |
0.294 |
|
| 2015 |
Lee HO, Mustafa A, Hudes GR, Kruger WD. Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. Plos One. 10: e0131464. PMID 26134285 DOI: 10.1371/Journal.Pone.0131464 |
0.294 |
|
| 2015 |
Lee H, Mustafa A, Hudes GR, Kruger WD. Abstract 5315: Hydroxychloroquine inhibits proliferation and S6 phosphorylation in human renal carcinoma cells Cancer Research. 75: 5315-5315. DOI: 10.1158/1538-7445.Am2015-5315 |
0.294 |
|
| 2011 |
Strakova J, Gupta S, Kruger WD, Dilger RN, Tryon K, Li L, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity. Nutrition Research (New York, N.Y.). 31: 563-71. PMID 21840473 DOI: 10.1016/J.Nutres.2011.06.004 |
0.293 |
|
| 2008 |
Mustafa A, Kruger WD. Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activated receptor gamma agonist in an in vivo mouse model of spontaneous breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 4935-42. PMID 18676768 DOI: 10.1158/1078-0432.Ccr-08-0958 |
0.289 |
|
| 2009 |
Zhang D, Jiang X, Fang P, Yan Y, Song J, Gupta S, Schafer AI, Durante W, Kruger WD, Yang X, Wang H. Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice. Circulation. 120: 1893-902. PMID 19858416 DOI: 10.1161/Circulationaha.109.866889 |
0.289 |
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| 2019 |
Al-Dewik N, Ali A, Mahmoud Y, Shahbeck N, Ali R, Mahmoud L, Al-Mureikhi M, Al-Mesaifri F, Musa S, El-Akouri K, AlMulla M, Al Saadi R, Nasrallah G, Samara M, Abdoh G, ... ... Kruger W, et al. Natural History, with Clinical, Biochemical and Molecular Characterization, of Classical Homocystinuria in the Qatari Population. Journal of Inherited Metabolic Disease. PMID 30968424 DOI: 10.1002/Jimd.12099 |
0.284 |
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| 1997 |
Malinow MR, Nieto FJ, Kruger WD, Duell PB, Hess DL, Gluckman RA, Block PC, Holzgang CR, Anderson PH, Seltzer D, Upson B, Lin QR. The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 1157-62. PMID 9194768 DOI: 10.1161/01.Atv.17.6.1157 |
0.283 |
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| 2021 |
Gupta S, Wang L, Slifker MJ, Cai KQ, Maclean KN, Wasek B, Bottiglieri T, Kruger WD. Analysis of differential neonatal lethality in cystathionine β-synthase deficient mouse models using metabolic profiling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21629. PMID 33949005 DOI: 10.1096/fj.202100302R |
0.28 |
|
| 2017 |
Lee HO, Uzzo RG, Kister D, Kruger WD. Combination of serum histidine and plasma tryptophan as a potential biomarker to detect clear cell renal cell carcinoma. Journal of Translational Medicine. 15: 72. PMID 28385150 DOI: 10.1186/S12967-017-1178-8 |
0.279 |
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| 2004 |
Chen X, Jhee KH, Kruger WD. Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. The Journal of Biological Chemistry. 279: 52082-6. PMID 15520012 DOI: 10.1074/Jbc.C400481200 |
0.279 |
|
| 2009 |
Pratico D, Zhuo J, Portugal GS, Kruger WD, Gould TJ. P4-044: Involvement of GSK3 in the homocysteine-dependent modulation of the Alzheimer-like phenotype in vivo Alzheimer's & Dementia. 5: P444-P444. DOI: 10.1016/J.Jalz.2009.04.914 |
0.278 |
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| 2001 |
Guttormsen AB, Ueland PM, Kruger WD, Kim CE, Ose L, Følling I, Refsum H. Disposition of homocysteine in subjects heterozygous for homocystinuria due to cystathionine beta-synthase deficiency: relationship between genotype and phenotype. American Journal of Medical Genetics. 100: 204-13. PMID 11343305 DOI: 10.1002/Ajmg.1247 |
0.274 |
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| 1998 |
Malinow MR, Duell PB, Hess DL, Anderson PH, Kruger WD, Phillipson BE, Gluckman RA, Block PC, Upson BM. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. The New England Journal of Medicine. 338: 1009-15. PMID 9535664 DOI: 10.1056/Nejm199804093381501 |
0.273 |
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| 2006 |
Tang B, Kadariya Y, Murphy ME, Kruger WD. The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase. Biochemical Pharmacology. 72: 806-15. PMID 16870157 DOI: 10.1016/J.Bcp.2006.06.018 |
0.271 |
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| 2021 |
Kruger WD. How to fix a broken protein: restoring function to mutant human cystathionine β-synthase. Human Genetics. PMID 34636997 DOI: 10.1007/s00439-021-02386-w |
0.268 |
|
| 2011 |
Kadariya Y, Tang B, Myers CB, Fukui J, Peterson JR, Kruger WD. Chemical genetic screening for compounds that preferentially inhibit growth of methylthioadenosine phosphorylase (MTAP)-deficient Saccharomyces cerevisiae. Journal of Biomolecular Screening. 16: 44-52. PMID 21131597 DOI: 10.1177/1087057110386371 |
0.265 |
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| 2012 |
Zhang D, Fang P, Jiang X, Nelson J, Moore JK, Kruger WD, Berretta RM, Houser SR, Yang X, Wang H. Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice. Circulation Research. 111: 37-49. PMID 22628578 DOI: 10.1161/Circresaha.112.269472 |
0.261 |
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| 2023 |
Gupta S, Lee HO, Wang L, Kruger WD. Examination of two different proteasome inhibitors in reactivating mutant human cystathionine β-synthase in mice. Plos One. 18: e0286550. PMID 37319242 DOI: 10.1371/journal.pone.0286550 |
0.261 |
|
| 2001 |
Malinow MR, Duell PB, Williams MA, Kruger WD, Evans AA, Anderson PH, Block PC, Hess DL, Upson BM, Graf EE, Irvin-Jones A, Wang L. Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations. Lipids. 36: S27-32. PMID 11837988 DOI: 10.1007/S11745-001-0678-8 |
0.261 |
|
| 2006 |
Pei J, Kruger WD, Testa JR. High-resolution analysis of 9p loss in human cancer cells using single nucleotide polymorphism-based mapping arrays. Cancer Genetics and Cytogenetics. 170: 65-8. PMID 16965958 DOI: 10.1016/J.Cancergencyto.2006.05.002 |
0.257 |
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| 2002 |
Christopher SA, Diegelman P, Porter CW, Kruger WD. Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line. Cancer Research. 62: 6639-44. PMID 12438261 |
0.255 |
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| 1999 |
Lobo A, Naso A, Arheart K, Kruger WD, Abou-Ghazala T, Alsous F, Nahlawi M, Gupta A, Moustapha A, van Lente F, Jacobsen DW, Robinson K. Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12. The American Journal of Cardiology. 83: 821-5. PMID 10190392 DOI: 10.1016/S0002-9149(98)01041-8 |
0.253 |
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| 2022 |
Deneka AY, Nikonova AS, Lee HO, Kruger WD, Golemis EA. NEDD9 sustains hexokinase expression to promote glycolysis. Oncogenesis. 11: 15. PMID 35410460 DOI: 10.1038/s41389-022-00391-w |
0.249 |
|
| 2006 |
Park ES, Oh HJ, Kruger WD, Jung SC, Lee JS. Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuria. Experimental & Molecular Medicine. 38: 652-61. PMID 17202841 DOI: 10.1038/emm.2006.77 |
0.249 |
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| 2021 |
Lee HO, Salami CO, Sondhi D, Kaminsky SM, Crystal RG, Kruger WD. Long-term functional correction of cystathionine β-synthase deficiency in mice by adeno-associated viral gene therapy. Journal of Inherited Metabolic Disease. PMID 34528713 DOI: 10.1002/jimd.12437 |
0.248 |
|
| 2019 |
Francescone R, Vendramini-Costa DB, Franco-Barraza J, Wagner J, Muir A, Gabitova L, Pazina T, Luong T, Shah N, Rollins D, Malik R, Gupta S, Thapa R, Restifo D, Lau A, ... ... Kruger WD, et al. Abstract 2038: NG1/NGL1 engagement supports PDAC development via CAF to PDAC nutrition and CAF-regulated immunosuppression Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2038 |
0.245 |
|
| 2023 |
Zainol Abidin QH, Ida T, Morita M, Matsunaga T, Nishimura A, Jung M, Hassan N, Takata T, Ishii I, Kruger W, Wang R, Motohashi H, Tsutsui M, Akaike T. Synthesis of Sulfides and Persulfides Is Not Impeded by Disruption of Three Canonical Enzymes in Sulfur Metabolism. Antioxidants (Basel, Switzerland). 12. PMID 37107243 DOI: 10.3390/antiox12040868 |
0.244 |
|
| 2011 |
Mustafa A, Gupta S, Hudes GR, Egleston BL, Uzzo RG, Kruger WD. Serum amino acid levels as a biomarker for renal cell carcinoma. The Journal of Urology. 186: 1206-12. PMID 21849193 DOI: 10.1016/J.Juro.2011.05.085 |
0.242 |
|
| 1994 |
Kruger WD, Cox DR. A yeast system for expression of human cystathionine beta-synthase: structural and functional conservation of the human and yeast genes. Proceedings of the National Academy of Sciences of the United States of America. 91: 6614-8. PMID 8022826 DOI: 10.1073/pnas.91.14.6614 |
0.237 |
|
| 2015 |
Tang B, Kruger W. Abstract 2048: Evidence that MTAP acts as a genetic switch to inhibit tumor formation Cancer Research. 75: 2048-2048. DOI: 10.1158/1538-7445.Am2015-2048 |
0.235 |
|
| 2023 |
Skvorak K, Mitchell V, Teadt L, Franklin KA, Lee HO, Kruse N, Huitt-Roehl C, Hang J, Du F, Galanie S, Guan S, Aijaz H, Zhang N, Rajkovic G, Kruger WD, et al. An orally administered enzyme therapeutic for homocystinuria that suppresses homocysteine by metabolizing methionine in the gastrointestinal tract. Molecular Genetics and Metabolism. 139: 107653. PMID 37463544 DOI: 10.1016/j.ymgme.2023.107653 |
0.231 |
|
| 2022 |
Tang B, Lee HO, Gupta S, Wang L, Kurimchak AM, Duncan JS, Kruger WD. Extracellular 5'-methylthioadenosine inhibits intracellular symmetric dimethylarginine protein methylation of FUSE-element binding proteins. The Journal of Biological Chemistry. 102367. PMID 35963436 DOI: 10.1016/j.jbc.2022.102367 |
0.229 |
|
| 2004 |
Tang B, Kruger WD, Chen G, Shen F, Lin WY, Mboup S, London WT, Evans AA. Hepatitis B viremia is associated with increased risk of hepatocellular carcinoma in chronic carriers. Journal of Medical Virology. 72: 35-40. PMID 14635008 DOI: 10.1002/Jmv.10559 |
0.219 |
|
| 2015 |
Majtan T, Bublil E, Park I, Carrillo R, Ereño-Orbea J, Martínez-Cruz LA, Hůlková H, Krijt J, Kožich V, Kruger W, Kraus JP. OP9 - CBS update: Structure, CBS replacement therapy, and H2S production Nitric Oxide. 47. DOI: 10.1016/J.Niox.2015.02.015 |
0.219 |
|
| 2013 |
Cheng Z, Jiang X, Durante W, Kruger WD, Yang X, Wang H. GW24-e3751 Oxidative stress-dependent cyclooxygenase 2-derived vasoconstrictive prostaglandins contribute to hyperhomocysteinemia-induced endothelial dysfunction in hyperlipidemia Heart. 99: A43.3-A44. DOI: 10.1136/Heartjnl-2013-304613.116 |
0.214 |
|
| 2022 |
Majtan T, Kožich V, Kruger WD. Recent therapeutic approaches to cystathionine beta-synthase-deficient homocystinuria. British Journal of Pharmacology. PMID 36417581 DOI: 10.1111/bph.15991 |
0.208 |
|
| 2001 |
Nozaki T, Shigeta Y, Saito-Nakano Y, Imada M, Kruger WD. Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma. The Journal of Biological Chemistry. 276: 6516-23. PMID 11106665 DOI: 10.1074/jbc.M009774200 |
0.207 |
|
| 2000 |
Tang B, Li YN, Kruger WD. Defects in methylthioadenosine phosphorylase are associated with but not responsible for methionine-dependent tumor cell growth. Cancer Research. 60: 5543-7. PMID 11034100 |
0.2 |
|
| 2008 |
Dayal S, Jensen MJ, Faraci FM, Kruger WD, Lentz SR. Endothelial Dysfunction and Paradoxical Resistance to Thrombosis in a Transgenic Mouse Model of Severe Hyperhomocysteinemia. Blood. 112: 1889-1889. DOI: 10.1182/BLOOD.V112.11.1889.1889 |
0.199 |
|
| 2015 |
Gupta S, Wang L, Kruger WD. Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice Journal of Inherited Metabolic Disease. DOI: 10.1007/s10545-015-9883-z |
0.198 |
|
| 2018 |
Gu SX, Sonkar V, Kumar R, Erland A, Bottiglieri T, Kruger W, Lentz S, Dayal S. Abstract WMP80: Cystathionine β Synthase Deficiency Exacerbates Cerebral Ischemia Reperfusion Injury Through Activation of the NMDA Receptor and Loss of Blood Brain Barrier Integrity in Mice Stroke. 49. DOI: 10.1161/Str.49.Suppl_1.Wmp80 |
0.191 |
|
| 2004 |
Apostolou S, Klein JO, Mitsuuchi Y, Shetler JN, Poulikakos PI, Jhanwar SC, Kruger WD, Testa JR. Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype. Oncogene. 23: 5032-40. PMID 15107826 DOI: 10.1038/sj.onc.1207683 |
0.188 |
|
| 2003 |
Cheon MS, Bajo M, Kim SH, Claudio JO, Stewart AK, Patterson D, Kruger WD, Kondoh H, Lubec G. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part II). Amino Acids. 24: 119-25. PMID 12624743 DOI: 10.1007/s00726-002-0337-1 |
0.185 |
|
| 2005 |
Ibrahim AF, Hedley PE, Cardle L, Kruger W, Marshall DF, Muehlbauer GJ, Waugh R. A comparative analysis of transcript abundance using SAGE and Affymetrix arrays. Functional & Integrative Genomics. 5: 163-74. PMID 15714318 DOI: 10.1007/S10142-005-0135-4 |
0.181 |
|
| 1987 |
DiBenedetto AJ, Lakich DM, Kruger WD, Belote JM, Baker BS, Wolfner MF. Sequences expressed sex-specifically in Drosophila melanogaster adults. Developmental Biology. 119: 242-51. PMID 3098604 DOI: 10.1016/0012-1606(87)90225-9 |
0.17 |
|
| 2010 |
Zhuo JM, Portugal GS, Kruger WD, Wang H, Gould TJ, Pratico D. Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease. Current Alzheimer Research. 7: 140-9. PMID 19939226 DOI: 10.2174/156720510790691326 |
0.163 |
|
| 2020 |
Francescone R, Barbosa Vendramini-Costa D, Franco-Barraza J, Wagner J, Muir A, Lau AN, Gabitova L, Pazina T, Gupta S, Luong T, Rollins D, Malik R, Thapa RJ, Restifo D, Zhou Y, ... ... Kruger WD, et al. Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression. Cancer Discovery. PMID 33127842 DOI: 10.1158/2159-8290.CD-20-0775 |
0.155 |
|
| 2022 |
Chang KT, Jezek J, Campbell AN, Stieg DC, Kiss ZA, Kemper K, Jiang P, Lee HO, Kruger WD, van Hasselt PM, Strich R. Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in syndrome fibroblasts. Iscience. 25: 103823. PMID 35198885 DOI: 10.1016/j.isci.2022.103823 |
0.146 |
|
| 2021 |
Padmanabhan N, Kyon HK, Boot A, Lim K, Srivastava S, Chen S, Wu Z, Lee HK, Mukundan VT, Chan C, Chan YK, Xuewen O, Pitt JJ, Isa ZFA, Xing M, ... ... Kruger WD, et al. Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation. Genome Biology. 22: 167. PMID 34074348 DOI: 10.1186/s13059-021-02375-2 |
0.132 |
|
| 1999 |
Steen MT, Boddie AM, Langley S, Cotsonis G, Macmahon W, Saxe D, Dembure PP, Kim C, Kruger WD, Elsas LJ. Biochemical discrimination of heterozygotes for cystathionine β-synthase (CβS) deficiency Genetics in Medicine. 1: 43-43. DOI: 10.1097/00125817-199901000-00016 |
0.102 |
|
| 2015 |
Imbard A, Benoist JF, Esse R, Gupta S, Lebon S, De Vriese AS, Ogier De Baulny H, Kruger W, Schiff M, Blom HJ. High homocysteine induces betaine depletion. Bioscience Reports. PMID 25919231 DOI: 10.1042/BSR20150094 |
0.079 |
|
| 2015 |
Lee HO, Mustafa A, Hudes GR, Kruger WD. Hydroxychloroquine destabilizes phospho-S6 in human renal carcinoma cells Plos One. 10. DOI: 10.1371/journal.pone.0131464 |
0.077 |
|
| 2021 |
Padmanabhan N, Kyon HK, Boot A, Lim K, Srivastava S, Chen S, Wu Z, Lee HO, Mukundan VT, Chan C, Chan YK, Xuewen O, Pitt JJ, Isa ZFA, Xing M, ... ... Kruger WD, et al. Author Correction: Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation. Genome Biology. 22: 181. PMID 34140045 DOI: 10.1186/s13059-021-02405-z |
0.073 |
|
| 1998 |
Siegmund W, Hoffmann C, Zschiesche M, Steinijans VW, Sauter R, Krüger WD, Diedrich F. Relative bioavailability of rapidly dispersing, plain, and microencapsuled acetylsalicylic acid tablets after single dose administration. International Journal of Clinical Pharmacology and Therapeutics. 36: 133-8. PMID 9562228 |
0.056 |
|
| 1988 |
Krause W, Kruger WD. Studies About Strength and Dynamic Rigidity at Housings of Big Turbo-Generators. . | UNTERSUCHUNGEN ZUR FESTIGKEIT UND DYNAMISCHEN STABILITAT AN GEHAUSEN GROBER TURBOGENERATOREN. Maschinenbautechnik. 37: 312-315. |
0.01 |
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