Year |
Citation |
Score |
2022 |
Olson KM, Campbell A, Alt A, Traynor JR. Finding the Perfect Fit: Conformational Biosensors to Determine the Efficacy of GPCR Ligands. Acs Pharmacology & Translational Science. 5: 694-709. PMID 36110374 DOI: 10.1021/acsptsci.1c00256 |
0.421 |
|
2021 |
Kandasamy R, Hillhouse TM, Livingston KE, Kochan KE, Meurice C, Eans SO, Li MH, White AD, Roques BP, McLaughlin JP, Ingram SL, Burford NT, Alt A, Traynor JR. Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33846240 DOI: 10.1073/pnas.2000017118 |
0.554 |
|
2019 |
Scott CE, Tang Y, Alt A, Burford NT, Gerritz SW, Ogawa LM, Zhang L, Kendall DA. Identification and biochemical analyses of selective CB agonists. European Journal of Pharmacology. PMID 30951717 DOI: 10.1016/J.Ejphar.2019.03.054 |
0.539 |
|
2017 |
Livingston KE, Stanczyk MA, Burford N, Alt A, Canals M, Traynor JR. Pharmacological Evidence for a Putative Conserved Allosteric Site on Opioid Receptors. Molecular Pharmacology. PMID 29233847 DOI: 10.1124/Mol.117.109561 |
0.646 |
|
2017 |
Carpenter J, Wang Y, Wu G, Feng J, Ye XY, Morales CL, Broekema M, Rossi KA, Miller KJ, Murphy BJ, Wu GY, Malmstrom SE, Azzara AV, Sher PM, Fevig JM, ... Alt A, et al. Utilization of an active site mutant receptor for the identification of potent and selective atypical 5-HT2C receptor agonists. Journal of Medicinal Chemistry. PMID 28635286 DOI: 10.1021/Acs.Jmedchem.7B00385 |
0.444 |
|
2017 |
Winters BL, Gregoriou GC, Kissiwaa SA, Wells OA, Medagoda DI, Hermes SM, Burford NT, Alt A, Aicher SA, Bagley EE. Endogenous opioids regulate moment-to-moment neuronal communication and excitability. Nature Communications. 8: 14611. PMID 28327612 DOI: 10.1038/ncomms14611 |
0.443 |
|
2016 |
Shang Y, Yeatman HR, Provasi D, Alt A, Christopoulos A, Canals M, Filizola M. Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors. Acs Chemical Biology. PMID 26841170 DOI: 10.1021/Acschembio.5B00712 |
0.531 |
|
2015 |
Alt A, Pendri A, Bertekap RL, Li G, Benitex Y, Nophsker M, Rockwell KL, Burford NT, Sum CS, Chen J, Herbst JJ, Ferrante M, Hendricson A, Cvijic ME, Westphal R, et al. Evidence for classical cholinergic toxicity associated with selective activation of M1 muscarinic receptors. The Journal of Pharmacology and Experimental Therapeutics. PMID 26582730 DOI: 10.1124/jpet.115.226910 |
0.387 |
|
2015 |
Bisignano P, Burford NT, Shang Y, Marlow B, Livingston KE, Fenton AM, Rockwell K, Budenholzer L, Traynor JR, Gerritz SW, Alt A, Filizola M. Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor. Journal of Chemical Information and Modeling. PMID 26347990 DOI: 10.1021/Acs.Jcim.5B00388 |
0.582 |
|
2015 |
Burford NT, Livingston KE, Canals M, Ryan MR, Budenholzer LM, Han Y, Shang Y, Herbst JJ, O'Connell J, Banks M, Zhang L, Filizola M, Bassoni DL, Wehrman TS, Christopoulos A, ... ... Alt A, et al. Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor. Journal of Medicinal Chemistry. 58: 4220-9. PMID 25901762 DOI: 10.1021/Acs.Jmedchem.5B00007 |
0.607 |
|
2014 |
Burford NT, Wehrman T, Bassoni D, O'Connell J, Banks M, Zhang L, Alt A. Identification of selective agonists and positive allosteric modulators for µ- and δ-opioid receptors from a single high-throughput screen. Journal of Biomolecular Screening. 19: 1255-65. PMID 25047277 DOI: 10.1177/1087057114542975 |
0.536 |
|
2014 |
Zhu Y, Watson J, Chen M, Shen DR, Yarde M, Agler M, Burford N, Alt A, Jayachandra S, Cvijic ME, Zhang L, Dyckman A, Xie J, O'Connell J, Banks M, et al. Integrating High-Content Analysis into a Multiplexed Screening Approach to Identify and Characterize GPCR Agonists. Journal of Biomolecular Screening. 19: 1079-1089. PMID 24789006 DOI: 10.1177/1087057114533146 |
0.341 |
|
2013 |
Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Clawson DK, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, et al. GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy. Bioorganic & Medicinal Chemistry Letters. 23: 6463-6. PMID 24140446 DOI: 10.1016/J.Bmcl.2013.09.045 |
0.339 |
|
2013 |
Burford NT, Clark MJ, Wehrman TS, Gerritz SW, Banks M, O'Connell J, Traynor JR, Alt A. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. 110: 10830-5. PMID 23754417 DOI: 10.1073/pnas.1300393110 |
0.638 |
|
2012 |
Noblin DJ, Bertekap RL, Burford NT, Hendricson A, Zhang L, Knox R, Banks M, O'Connell J, Alt A. Development of a high-throughput calcium flux assay for identification of all ligand types including positive, negative, and silent allosteric modulators for G protein-coupled receptors. Assay and Drug Development Technologies. 10: 457-67. PMID 22746835 DOI: 10.1089/Adt.2011.443 |
0.343 |
|
2011 |
Burford NT, Watson J, Bertekap R, Alt A. Strategies for the identification of allosteric modulators of G-protein-coupled receptors. Biochemical Pharmacology. 81: 691-702. PMID 21184747 DOI: 10.1016/j.bcp.2010.12.012 |
0.523 |
|
2007 |
Alt A, Weiss B, Ornstein PL, Gleason SD, Bleakman D, Stratford RE, Witkin JM. Anxiolytic-like effects through a GLUK5 kainate receptor mechanism. Neuropharmacology. 52: 1482-7. PMID 17418283 DOI: 10.1016/J.Neuropharm.2007.02.005 |
0.445 |
|
2007 |
Dolman NP, More JC, Alt A, Knauss JL, Pentikäinen OT, Glasser CR, Bleakman D, Mayer ML, Collingridge GL, Jane DE. Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. Journal of Medicinal Chemistry. 50: 1558-70. PMID 17348638 DOI: 10.1021/Jm061041U |
0.347 |
|
2006 |
Jones CK, Alt A, Ogden AM, Bleakman D, Simmons RM, Iyengar S, Dominguez E, Ornstein PL, Shannon HE. Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats. The Journal of Pharmacology and Experimental Therapeutics. 319: 396-404. PMID 16837561 DOI: 10.1124/Jpet.106.105601 |
0.367 |
|
2006 |
Weiss B, Alt A, Ogden AM, Gates M, Dieckman DK, Clemens-Smith A, Ho KH, Jarvie K, Rizkalla G, Wright RA, Calligaro DO, Schoepp D, Mattiuz EL, Stratford RE, Johnson B, et al. Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 318: 772-81. PMID 16690725 DOI: 10.1124/Jpet.106.101428 |
0.359 |
|
2006 |
Alt A, Weiss B, Ogden AM, Li X, Gleason SD, Calligaro DO, Bleakman D, Witkin JM. In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders. Psychopharmacology. 185: 240-7. PMID 16470401 DOI: 10.1007/S00213-005-0292-0 |
0.359 |
|
2006 |
Alt A, Nisenbaum ES, Bleakman D, Witkin JM. A role for AMPA receptors in mood disorders. Biochemical Pharmacology. 71: 1273-88. PMID 16442080 DOI: 10.1016/J.Bcp.2005.12.022 |
0.402 |
|
2005 |
Dolman NP, Troop HM, More JC, Alt A, Knauss JL, Nistico R, Jack S, Morley RM, Bortolotto ZA, Roberts PJ, Bleakman D, Collingridge GL, Jane DE. Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. Journal of Medicinal Chemistry. 48: 7867-81. PMID 16302825 DOI: 10.1021/jm050584l |
0.445 |
|
2005 |
Dominguez E, Iyengar S, Shannon HE, Bleakman D, Alt A, Arnold BM, Bell MG, Bleisch TJ, Buckmaster JL, Castano AM, Del Prado M, Escribano A, Filla SA, Ho KH, Hudziak KJ, et al. Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain. Journal of Medicinal Chemistry. 48: 4200-3. PMID 15974569 DOI: 10.1021/Jm0491952 |
0.406 |
|
2004 |
More JC, Nistico R, Dolman NP, Clarke VR, Alt AJ, Ogden AM, Buelens FP, Troop HM, Kelland EE, Pilato F, Bleakman D, Bortolotto ZA, Collingridge GL, Jane DE. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 47: 46-64. PMID 15165833 DOI: 10.1016/J.Neuropharm.2004.03.005 |
0.429 |
|
2002 |
Alt A, Clark MJ, Woods JH, Traynor JR. Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells. British Journal of Pharmacology. 135: 217-25. PMID 11786497 DOI: 10.1038/Sj.Bjp.0704430 |
0.48 |
|
2000 |
Remmers AE, Clark MJ, Alt A, Medzihradsky F, Woods JH, Traynor JR. Activation of G protein by opioid receptors: role of receptor number and G-protein concentration. European Journal of Pharmacology. 396: 67-75. PMID 10822058 DOI: 10.1016/S0014-2999(00)00212-0 |
0.486 |
|
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