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Kinya Hotta, Ph.D. - Publications

Affiliations: 
2001 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
chemical biology
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Yamamoto T, Tsunematsu Y, Hara K, Suzuki T, Kishimoto S, Kawagishi H, Noguchi H, Hashimoto H, Tang Y, Hotta K, Watanabe K. Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis. Angewandte Chemie (International Ed. in English). PMID 27072782 DOI: 10.1002/Anie.201600940  0.327
2015 Yamamoto T, Tsunematsu Y, Noguchi H, Hotta K, Watanabe K. Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone, and exo-Methylene Formation. Organic Letters. PMID 26414728 DOI: 10.1021/Acs.Orglett.5B02435  0.364
2015 Sato M, Yagishita F, Mino T, Uchiyama N, Patel A, Chooi YH, Goda Y, Xu W, Noguchi H, Yamamoto T, Hotta K, Houk KN, Tang Y, Watanabe K. Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition. Chembiochem : a European Journal of Chemical Biology. PMID 26360642 DOI: 10.1002/Cbic.201500386  0.356
2015 Wong FT, Hotta K, Chen X, Fang M, Watanabe K, Kim CY. Epoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis. Journal of the American Chemical Society. 137: 86-9. PMID 25535803 DOI: 10.1021/Ja511374K  0.395
2015 Sato M, Yamada H, Hotta K, Watanabe K. Elucidation of the shanorellin biosynthetic pathway and functional analysis of associated enzymes Medchemcomm. 6: 425-430. DOI: 10.1039/C4Md00352G  0.358
2014 Ishikawa N, Tanaka H, Koyama F, Noguchi H, Wang CC, Hotta K, Watanabe K. Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids. Angewandte Chemie (International Ed. in English). 53: 12880-4. PMID 25251934 DOI: 10.1002/Anie.201407920  0.339
2014 Tsunematsu Y, Fukutomi M, Saruwatari T, Noguchi H, Hotta K, Tang Y, Watanabe K. Elucidation of pseurotin biosynthetic pathway points to trans-acting C-methyltransferase: generation of chemical diversity. Angewandte Chemie (International Ed. in English). 53: 8475-9. PMID 24939566 DOI: 10.1002/Anie.201404804  0.377
2014 Saruwatari T, Yagishita F, Mino T, Noguchi H, Hotta K, Watanabe K. Cytochrome P450 as dimerization catalyst in diketopiperazine alkaloid biosynthesis. Chembiochem : a European Journal of Chemical Biology. 15: 656-9. PMID 24677498 DOI: 10.1002/Cbic.201300751  0.355
2014 Hotta K, Keegan RM, Ranganathan S, Fang M, Bibby J, Winn MD, Sato M, Lian M, Watanabe K, Rigden DJ, Kim CY. Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis. Angewandte Chemie (International Ed. in English). 53: 824-8. PMID 24302672 DOI: 10.1002/Anie.201307404  0.332
2013 Tsunematsu Y, Ishikawa N, Wakana D, Goda Y, Noguchi H, Moriya H, Hotta K, Watanabe K. Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk. Nature Chemical Biology. 9: 818-25. PMID 24121553 DOI: 10.1038/Nchembio.1366  0.371
2013 Nakazawa T, Ishiuchi K, Sato M, Tsunematsu Y, Sugimoto S, Gotanda Y, Noguchi H, Hotta K, Watanabe K. Targeted disruption of transcriptional regulators in Chaetomium globosum activates biosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol. Journal of the American Chemical Society. 135: 13446-55. PMID 23941144 DOI: 10.1021/Ja405128K  0.355
2013 Tsunematsu Y, Ishiuchi K, Hotta K, Watanabe K. Yeast-based genome mining, production and mechanistic studies of the biosynthesis of fungal polyketide and peptide natural products. Natural Product Reports. 30: 1139-49. PMID 23824111 DOI: 10.1039/C3Np70037B  0.351
2013 Ishiuchi K, Nakazawa T, Yagishita F, Mino T, Noguchi H, Hotta K, Watanabe K. Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis. Journal of the American Chemical Society. 135: 7371-7. PMID 23611317 DOI: 10.1021/Ja402828W  0.376
2012 Nakazawa T, Ishiuchi K, Praseuth A, Noguchi H, Hotta K, Watanabe K. Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce a novel polyketide. Chembiochem : a European Journal of Chemical Biology. 13: 855-61. PMID 22447538 DOI: 10.1002/Cbic.201200107  0.327
2012 Ishiuchi K, Nakazawa T, Ookuma T, Sugimoto S, Sato M, Tsunematsu Y, Ishikawa N, Noguchi H, Hotta K, Moriya H, Watanabe K. Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics. Chembiochem : a European Journal of Chemical Biology. 13: 846-54. PMID 22447505 DOI: 10.1002/Cbic.201100798  0.349
2012 Hotta K, Chen X, Paton RS, Minami A, Li H, Swaminathan K, Mathews II, Watanabe K, Oikawa H, Houk KN, Kim CY. Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis. Nature. 483: 355-8. PMID 22388816 DOI: 10.1038/Nature10865  0.396
2011 Minami A, Migita A, Inada D, Hotta K, Watanabe K, Oguri H, Oikawa H. Enzymatic epoxide-opening cascades catalyzed by a pair of epoxide hydrolases in the ionophore polyether biosynthesis. Organic Letters. 13: 1638-41. PMID 21375229 DOI: 10.1021/Ol200100E  0.315
2009 Watanabe K, Hotta K, Praseuth AP, Searcey M, Wang CC, Oguri H, Oikawa H. Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli. Chembiochem : a European Journal of Chemical Biology. 10: 1965-8. PMID 19588480 DOI: 10.1002/Cbic.200900260  0.311
2009 Watanabe K, Hotta K, Nakaya M, Praseuth AP, Wang CC, Inada D, Takahashi K, Fukushi E, Oguri H, Oikawa H. Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product. Journal of the American Chemical Society. 131: 9347-53. PMID 19514719 DOI: 10.1021/Ja902261A  0.377
2009 Watanabe K, Praseuth AP, Praseuth MB, Hotta K. Chapter 15. Plasmid-borne gene cluster assemblage and heterologous biosynthesis of nonribosomal peptides in Escherichia coli. Methods in Enzymology. 458: 379-99. PMID 19374991 DOI: 10.1016/S0076-6879(09)04815-0  0.389
2008 Praseuth AP, Wang CC, Watanabe K, Hotta K, Oguri H, Oikawa H. Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus. Biotechnology Progress. 24: 1226-31. PMID 19194935 DOI: 10.1002/Btpr.34  0.31
2006 Watanabe K, Hotta K, Praseuth AP, Koketsu K, Migita A, Boddy CN, Wang CC, Oguri H, Oikawa H. Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. Nature Chemical Biology. 2: 423-8. PMID 16799553 DOI: 10.1038/Nchembio803  0.342
2004 Hu Y, Houk KN, Kikuchi K, Hotta K, Hilvert D. Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles. Journal of the American Chemical Society. 126: 8197-205. PMID 15225061 DOI: 10.1021/Ja0490727  0.531
2004 Boddy CN, Hotta K, Tse ML, Watts RE, Khosla C. Precursor-directed biosynthesis of epothilone in Escherichia coli. Journal of the American Chemical Society. 126: 7436-7. PMID 15198579 DOI: 10.1021/Ja048108S  0.347
2003 Ujaque G, Tantillo DJ, Hu Y, Houk KN, Hotta K, Hilvert D. Catalysis on the coastline: theozyme, molecular dynamics, and free energy perturbation analysis of antibody 21D8 catalysis of the decarboxylation of 5-nitro-3-carboxybenzisoxazole. Journal of Computational Chemistry. 24: 98-110. PMID 12483679 DOI: 10.1002/Jcc.10151  0.555
2003 Backes AC, Hotta K, Hilvert D. Promiscuity in Antibody Catalysis: Esterolytic Activity of the Decarboxylase 21D8 Helvetica Chimica Acta. 86: 1167-1174. DOI: 10.1002/Hlca.200390101  0.543
2002 Hotta K, Wilson IA, Hilvert D. Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism. Biochemistry. 41: 772-9. PMID 11790098 DOI: 10.1021/Bi0158167  0.54
2000 Hotta K, Lange H, Tantillo DJ, Houk KN, Hilvert D, Wilson IA. Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8. Journal of Molecular Biology. 302: 1213-25. PMID 11183784 DOI: 10.1006/Jmbi.2000.4503  0.553
2000 Hotta K, Kikuchi K, Hilvert D. Catalysis of 3‐Carboxy‐1,2‐benzisoxazole Decarboxylation by Hydrophobic Antibody Binding Pockets Helvetica Chimica Acta. 83: 2183-2191. DOI: 10.1002/1522-2675(20000906)83:9<2183::Aid-Hlca2183>3.0.Co;2-C  0.549
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