| Year |
Citation |
Score |
| 2023 |
Poeggeler B, Singh SK, Sambamurti K, Pappolla MA. Nitric Oxide as a Determinant of Human Longevity and Health Span. International Journal of Molecular Sciences. 24. PMID 37833980 DOI: 10.3390/ijms241914533 |
0.503 |
|
| 2023 |
Poeggeler B, Singh SK, Sambamurti K, Pappolla MA. Tryptophan in Nutrition and Health 2.0. International Journal of Molecular Sciences. 24. PMID 37108272 DOI: 10.3390/ijms24087112 |
0.464 |
|
| 2023 |
Pappolla MA, Carare RO, Poeggeler B, Wisniewski T, Sambamurti K. The Lymphatic System in Neurological Disease and Alzheimer's Disease. A Brief Editorial. Current Alzheimer Research. 19: 689-693. PMID 36306458 DOI: 10.2174/1567205020666221028111517 |
0.595 |
|
| 2021 |
Cui J, Ait-Ghezala G, Sambamurti K, Gao F, Shen Y, Li R. Sex-specific regulation of β-Secretase: a novel estrogen response element (ERE)-dependent mechanism in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34903570 DOI: 10.1523/JNEUROSCI.0864-20.2021 |
0.325 |
|
| 2021 |
Pappolla MA, Perry G, Fang X, Zagorski M, Sambamurti K, Poeggeler B. Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease. Neurobiology of Disease. 105403. PMID 34087380 DOI: 10.1016/j.nbd.2021.105403 |
0.653 |
|
| 2020 |
Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Correction: Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease. Translational Psychiatry. 10: 81. PMID 32123156 DOI: 10.1038/S41398-020-0757-2 |
0.383 |
|
| 2020 |
Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease. Translational Psychiatry. 10: 47. PMID 32066688 DOI: 10.1038/S41398-020-0709-X |
0.502 |
|
| 2018 |
Teich AF, Sharma E, Barnwell E, Zhang H, Staniszewski A, Utsuki T, Padmaraju V, Mazell C, Tzekou A, Sambamurti K, Arancio O, Maccecchini ML. Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse. Alzheimer's & Dementia (New York, N. Y.). 4: 37-45. PMID 29955650 DOI: 10.1016/J.Trci.2017.12.001 |
0.492 |
|
| 2018 |
Pappolla MA, Matsubara E, Vidal R, Pacheco-Quinto J, Poeggeler B, Zagorski M, Sambamurti K. Melatonin treatment enhances Aβ lymphatic clearance in a transgenic mouse model of amyloidosis. Current Alzheimer Research. PMID 29637859 DOI: 10.2174/1567205015666180411092551 |
0.701 |
|
| 2015 |
Baranello RJ, Bharani KL, Padmaraju V, Chopra N, Lahiri DK, Greig NH, Pappolla MA, Sambamurti K. Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Current Alzheimer Research. 12: 32-46. PMID 25523424 DOI: 10.2174/1567205012666141218140953 |
0.728 |
|
| 2015 |
Wang X, Zhu M, Hjorth E, Cortés-Toro V, Eyjolfsdottir H, Graff C, Nennesmo I, Palmblad J, Eriksdotter M, Sambamurti K, Fitzgerald JM, Serhan CN, Granholm AC, Schultzberg M. Resolution of inflammation is altered in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 40-50.e1-2. PMID 24530025 DOI: 10.1016/J.Jalz.2013.12.024 |
0.427 |
|
| 2015 |
Lahiri DK, Maloney B, Long J, Chopra N, Bayon BL, Greig NH, Sambamurti K, Spence J, Ray B. P2-048: Does the mini-mental state examination (MMSE) measure a deeper biological process? modeling mmse score versus three selected mirna levels may reveal pathological roles in Alzheimer's disease progression Alzheimer's & Dementia. 11: P499-P500. DOI: 10.1016/J.Jalz.2015.06.584 |
0.335 |
|
| 2015 |
Sambamurti K, Greig NH, Baranello RJ, Chinnakkanu P, Lahiri DK, Padmaraju V. P4-156: Methionine restriction leads to Aβ reduction and neuroprotection: Implications in Alzheimer's disease pathogenesis and prevention Alzheimer's & Dementia. 11: P838-P839. DOI: 10.1016/J.Jalz.2015.06.1863 |
0.489 |
|
| 2014 |
Zhao Y, Bhattacharjee S, Jones BM, Hill JM, Clement C, Sambamurti K, Dua P, Lukiw WJ. Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD). Molecular Neurobiology. PMID 25204496 DOI: 10.1007/S12035-014-8886-3 |
0.537 |
|
| 2014 |
Greig NH, Sambamurti K, Lahiri DK, Becker RE. Amyloid-β precursor protein synthesis inhibitors for Alzheimer's disease treatment. Annals of Neurology. 76: 629-30. PMID 25146731 DOI: 10.1002/Ana.24254 |
0.464 |
|
| 2014 |
Pappolla M, Sambamurti K, Vidal R, Pacheco-Quinto J, Poeggeler B, Matsubara E. Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice. Neurobiology of Disease. 71: 215-9. PMID 25102344 DOI: 10.1016/J.Nbd.2014.07.012 |
0.659 |
|
| 2014 |
Barnwell E, Padmaraju V, Baranello R, Pacheco-Quinto J, Crosson C, Ablonczy Z, Eckman E, Eckman CB, Ramakrishnan V, Greig NH, Pappolla MA, Sambamurti K. Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein. Plos One. 9: e91531. PMID 24658363 DOI: 10.1371/Journal.Pone.0091531 |
0.652 |
|
| 2014 |
Pappolla M, Sambamurti K, Vidal R, Pacheco-Quinto J, Poeggeler B, Matsubara E. Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice Neurobiology of Disease. 71: 215-219. DOI: 10.1016/j.nbd.2014.07.012 |
0.629 |
|
| 2013 |
Pinnix I, Ghiso JA, Pappolla MA, Sambamurti K. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 21: 474-83. PMID 23570890 DOI: 10.1016/J.Jagp.2013.02.009 |
0.665 |
|
| 2013 |
Yu QS, Reale M, Kamal MA, Holloway HW, Luo W, Sambamurti K, Ray B, Lahiri DK, Rogers JT, Greig NH. Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergic action. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 12: 117-28. PMID 23360256 DOI: 10.2174/1871523011312020003 |
0.45 |
|
| 2012 |
Vidal R, Sammeta N, Garringer HJ, Sambamurti K, Miravalle L, Lamb BT, Ghetti B. The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2899-910. PMID 22459153 DOI: 10.1096/Fj.12-205542 |
0.474 |
|
| 2012 |
Maloney B, Sambamurti K, Zawia N, Lahiri DK. Applying epigenetics to Alzheimer's disease via the latent early-life associated regulation (LEARn) model. Current Alzheimer Research. 9: 589-99. PMID 22300406 DOI: 10.2174/156720512800617955 |
0.477 |
|
| 2012 |
Sambamurti K, Vasudevaraju P. Can the Failure of Alzheimer?s Disease Clinical Trials be Stepping Stones to Ultimate Success: Is the Amyloid Hypothesis Discredited by Animal Models Journal of Alzheimer’S Disease & Parkinsonism. 2. DOI: 10.4172/2161-0460.1000E115 |
0.415 |
|
| 2012 |
Ghetti B, Vidal R, Sammeta N, Garringer H, Sambamurti K, Miravalle L, Lamb B. The Psen1-L166P knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice Alzheimers & Dementia. 8: 86. DOI: 10.1016/J.Jalz.2012.05.209 |
0.405 |
|
| 2011 |
Britton GB, Smith MA, Perry G, Sambamurti K, Jagannatha Rao KS. Drug discovery for neurodegenerative diseases: challenges and novel biochemical targets dedicated to the memory of Mark A. Smith for his inspiring contribution to Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 24: 1-2. PMID 21525570 DOI: 10.3233/Jad-2011-110021 |
0.408 |
|
| 2011 |
Yu J, Gattoni-Celli M, Zhu H, Bhat NR, Sambamurti K, Gattoni-Celli S, Kindy MS. Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice. Journal of Alzheimer's Disease : Jad. 25: 295-307. PMID 21422528 DOI: 10.3233/Jad-2011-101986 |
0.425 |
|
| 2011 |
Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA. Targets for AD treatment: conflicting messages from γ-secretase inhibitors. Journal of Neurochemistry. 117: 359-74. PMID 21320126 DOI: 10.1111/J.1471-4159.2011.07213.X |
0.716 |
|
| 2010 |
Poeggeler B, Sambamurti K, Siedlak SL, Perry G, Smith MA, Pappolla MA. A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan. Plos One. 5: e10206. PMID 20421998 DOI: 10.1371/Journal.Pone.0010206 |
0.553 |
|
| 2010 |
Prakasam A, Muthuswamy A, Ablonczy Z, Greig NH, Fauq A, Rao KJ, Pappolla MA, Sambamurti K. Differential accumulation of secreted AbetaPP metabolites in ocular fluids. Journal of Alzheimer's Disease : Jad. 20: 1243-53. PMID 20413851 DOI: 10.3233/Jad-2010-100210 |
0.685 |
|
| 2010 |
Li Y, Duffy KB, Ottinger MA, Ray B, Bailey JA, Holloway HW, Tweedie D, Perry T, Mattson MP, Kapogiannis D, Sambamurti K, Lahiri DK, Greig NH. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 19: 1205-19. PMID 20308787 DOI: 10.3233/Jad-2010-1314 |
0.506 |
|
| 2010 |
Ramesh BN, Rao TS, Prakasam A, Sambamurti K, Rao KS. Neuronutrition and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 19: 1123-39. PMID 20308778 DOI: 10.3233/Jad-2010-1312 |
0.428 |
|
| 2010 |
Zambón D, Quintana M, Mata P, Alonso R, Benavent J, Cruz-Sánchez F, Gich J, Pocovà M, Civeira F, Capurro S, Bachman D, Sambamurti K, Nicholas J, Pappolla MA. Higher incidence of mild cognitive impairment in familial hypercholesterolemia. The American Journal of Medicine. 123: 267-74. PMID 20193836 DOI: 10.1016/J.Amjmed.2009.08.015 |
0.561 |
|
| 2009 |
Sambamurti K, Jagannatha Rao KS, Pappolla MA. Frontiers in the pathogenesis of Alzheimer's disease. Indian Journal of Psychiatry. 51: S56-60. PMID 21416019 |
0.674 |
|
| 2009 |
Ablonczy Z, Prakasam A, Fant J, Fauq A, Crosson C, Sambamurti K. Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase. The Journal of Biological Chemistry. 284: 30177-86. PMID 19723623 DOI: 10.1074/Jbc.M109.032391 |
0.301 |
|
| 2009 |
Hegde ML, Bharathi P, Suram A, Venugopal C, Jagannathan R, Poddar P, Srinivas P, Sambamurti K, Rao KJ, Scancar J, Messori L, Zecca L, Zatta P. Challenges associated with metal chelation therapy in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 17: 457-68. PMID 19363258 DOI: 10.3233/Jad-2009-1068 |
0.664 |
|
| 2009 |
Nicolle MM, Watson ML, McQuail JA, Sambamurti K, Brady AE, Jones C, Conn PJ, Lindsey CW. P3-276: Acute administration of a novel M1 receptor allosteric potentiator (BQCA) restores reversal learning in a transgenic mouse model of Alzheimer's disease (Tg2576) Alzheimer's & Dementia. 5: P424-P424. DOI: 10.1016/J.Jalz.2009.04.947 |
0.346 |
|
| 2008 |
Zhuo JM, Prakasam A, Murray ME, Zhang HY, Baxter MG, Sambamurti K, Nicolle MM. An increase in Abeta42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice. Current Alzheimer Research. 5: 385-91. PMID 18690835 DOI: 10.2174/156720508785132280 |
0.457 |
|
| 2008 |
Venugopal C, Demos CM, Rao KS, Pappolla MA, Sambamurti K. Beta-secretase: structure, function, and evolution. Cns & Neurological Disorders Drug Targets. 7: 278-94. PMID 18673212 DOI: 10.2174/187152708784936626 |
0.786 |
|
| 2008 |
Lahiri DK, Zawia NH, Greig NH, Sambamurti K, Maloney B. Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model. Biogerontology. 9: 375-9. PMID 18668339 DOI: 10.1007/S10522-008-9162-6 |
0.412 |
|
| 2008 |
Sambamurti K, Pappolla MA, Jagannatha Rao KS. Value in development of a TAPIR-like mouse monoclonal antibody to Abeta. Journal of Alzheimer's Disease : Jad. 14: 175-7. PMID 18663823 DOI: 10.3233/Jad-2008-14205 |
0.722 |
|
| 2008 |
Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy MS, Bhat NR. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice Journal of Neurochemistry. 106: 475-485. PMID 18410513 DOI: 10.1111/J.1471-4159.2008.05415.X |
0.391 |
|
| 2008 |
Zhou Y, Suram A, Venugopal C, Prakasam A, Lin S, Su Y, Li B, Paul SM, Sambamurti K. Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 47-54. PMID 17666454 DOI: 10.1096/Fj.07-8175Com |
0.71 |
|
| 2008 |
Sambamurti K, Prakasam A, Jayachandran AD, Venugopal C, Rao JK, Lahiri DK, Greig NH, Pappolla MA, Zhou Y. P1-412: Isoprenoids phenocopy familial Alzheimer's disease mutations and regulate gamma-secretase Alzheimer's & Dementia. 4: T340-T340. DOI: 10.1016/J.Jalz.2008.05.994 |
0.738 |
|
| 2008 |
Pappolla MA, Ros E, Sambamurti K, Pocovi M, Nicholas J, Mata P, Alonso R, Bachman D, Cruz-Sanchez F, Benavent J, Capurro S, Zambon D. O1-01-08: Cognitive impairment in heterozygous familial hypercholesterolemia Alzheimer's & Dementia. 4: T108-T108. DOI: 10.1016/J.Jalz.2008.05.218 |
0.529 |
|
| 2008 |
Pacheco-Quinto J, Sambamurti K, Pappolla MA. P3-343: Homocysteine inhibits the enzymatic degradation of Aβ peptide Alzheimer's & Dementia. 4: T622-T622. DOI: 10.1016/J.Jalz.2008.05.1912 |
0.619 |
|
| 2007 |
Tweedie D, Sambamurti K, Greig NH. TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets. Current Alzheimer Research. 4: 378-85. PMID 17908040 DOI: 10.2174/156720507781788873 |
0.33 |
|
| 2007 |
Venugopal C, Pappolla MA, Sambamurti K. Insulysin cleaves the APP cytoplasmic fragment at multiple sites. Neurochemical Research. 32: 2225-34. PMID 17701350 DOI: 10.1007/S11064-007-9449-Z |
0.78 |
|
| 2007 |
Lahiri DK, Chen D, Maloney B, Holloway HW, Yu QS, Utsuki T, Giordano T, Sambamurti K, Greig NH. The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. The Journal of Pharmacology and Experimental Therapeutics. 320: 386-96. PMID 17003227 DOI: 10.1124/Jpet.106.112102 |
0.558 |
|
| 2006 |
Lahiri DK, Ge YW, Rogers JT, Sambamurti K, Greig NH, Maloney B. Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. Current Alzheimer Research. 3: 475-83. PMID 17168646 DOI: 10.2174/156720506779025224 |
0.448 |
|
| 2006 |
Suram A, Venugopal C, Prakasam A, Sambamurti K. Genotoxicity in Alzheimer's disease: role of amyloid. Current Alzheimer Research. 3: 365-75. PMID 17017867 DOI: 10.2174/156720506778249380 |
0.747 |
|
| 2006 |
Tweedie D, Brossi A, Chen D, Ge YW, Bailey J, Yu QS, Kamal MA, Sambamurti K, Lahiri DK, Greig NH. Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 10: 9-16. PMID 16988475 DOI: 10.3233/Jad-2006-10102 |
0.527 |
|
| 2006 |
Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 51: 29-42. PMID 16815330 DOI: 10.1016/J.Neuron.2006.05.022 |
0.389 |
|
| 2006 |
Utsuki T, Yu QS, Davidson D, Chen D, Holloway HW, Brossi A, Sambamurti K, Lahiri DK, Greig NH, Giordano T. Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide. The Journal of Pharmacology and Experimental Therapeutics. 318: 855-62. PMID 16690718 DOI: 10.1124/Jpet.106.103309 |
0.501 |
|
| 2006 |
Pacheco-Quinto J, Rodriguez de Turco EB, DeRosa S, Howard A, Cruz-Sanchez F, Sambamurti K, Refolo L, Petanceska S, Pappolla MA. Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels. Neurobiology of Disease. 22: 651-6. PMID 16516482 DOI: 10.1016/J.Nbd.2006.01.005 |
0.713 |
|
| 2006 |
Sambamurti K, Suram A, Venugopal C, Prakasam A, Zhou Y, Lahiri DK, Greig NH. A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis. Current Alzheimer Research. 3: 81-90. PMID 16472208 DOI: 10.2174/156720506775697142 |
0.753 |
|
| 2006 |
Bruinsma G, Cullen E, Greig NH, Lahiri D, Sambamurti K, Friedhoff L. P1-004: Oral treatment of mice with Posiphen™
significantly lowers brain levels of beta amyloid (1-42) Alzheimer's & Dementia. 2: S95-S95. DOI: 10.1016/J.Jalz.2006.05.379 |
0.386 |
|
| 2006 |
Sambamurti K, Prakasam A, Anitha S, Venugopal C, Cullen E, Zhou Y, Bruinsma G, Lahiri DK, Greig NH, Friedhoff L. P2-417: Oral phenserine tartrate treatment is associated with reduced plasma Abeta 1-42 in a phase I clinical study Alzheimer's & Dementia. 2: S369-S370. DOI: 10.1016/J.Jalz.2006.05.1258 |
0.628 |
|
| 2006 |
Lockrow J, Willis L, Granholm A, Sambamurti K. APP accumulation and inflammation in the Ts65dn mouse, a model for Down's syndrome Experimental Neurology. 198: 578. DOI: 10.1016/J.Expneurol.2006.02.065 |
0.307 |
|
| 2005 |
Granholm AC, Bachman D, Mintzer J, Sambamurti K. Commentary: "Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified?" by Claudio Costantini, Rekha M.K. Kolasani, Luigi Puglielli. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 1: 53-4. PMID 19595818 DOI: 10.1016/J.Jalz.2005.06.010 |
0.366 |
|
| 2005 |
Greig NH, Utsuki T, Ingram DK, Wang Y, Pepeu G, Scali C, Yu QS, Mamczarz J, Holloway HW, Giordano T, Chen D, Furukawa K, Sambamurti K, Brossi A, Lahiri DK. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proceedings of the National Academy of Sciences of the United States of America. 102: 17213-8. PMID 16275899 DOI: 10.1073/Pnas.0508575102 |
0.494 |
|
| 2005 |
Greig NH, Sambamurti K, Yu QS, Brossi A, Bruinsma GB, Lahiri DK. An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Current Alzheimer Research. 2: 281-90. PMID 15974893 DOI: 10.2174/1567205054367829 |
0.514 |
|
| 2004 |
Greig NH, Mattson MP, Perry T, Chan SL, Giordano T, Sambamurti K, Rogers JT, Ovadia H, Lahiri DK. New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists. Annals of the New York Academy of Sciences. 1035: 290-315. PMID 15681814 DOI: 10.1196/Annals.1332.018 |
0.413 |
|
| 2004 |
Lahiri DK, Rogers JT, Greig NH, Sambamurti K. Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents. Current Pharmaceutical Design. 10: 3111-9. PMID 15544501 DOI: 10.2174/1381612043383331 |
0.526 |
|
| 2004 |
Gandhi S, Refolo LM, Sambamurti K. Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization. Journal of Molecular Neuroscience : Mn. 24: 137-43. PMID 15314262 DOI: 10.1385/Jmn:24:1:137 |
0.514 |
|
| 2004 |
Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, Mintzer JE. Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Current Drug Targets. 5: 517-28. PMID 15270198 DOI: 10.2174/1389450043345335 |
0.562 |
|
| 2004 |
Lahiri DK, Sambamurti K, Bennett DA. Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease. Neurobiology of Aging. 25: 651-60. PMID 15172744 DOI: 10.1016/J.Neurobiolaging.2003.12.024 |
0.466 |
|
| 2004 |
Brown J, Theisler C, Silberman S, Magnuson D, Gottardi-Littell N, Lee JM, Yager D, Crowley J, Sambamurti K, Rahman MM, Reiss AB, Eckman CB, Wolozin B. Differential expression of cholesterol hydroxylases in Alzheimer's disease. The Journal of Biological Chemistry. 279: 34674-81. PMID 15148325 DOI: 10.1074/Jbc.M402324200 |
0.482 |
|
| 2004 |
Sambamurti K, Kinsey R, Maloney B, Ge YW, Lahiri DK. Gene structure and organization of the human beta-secretase (BACE) promoter. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1034-6. PMID 15059975 DOI: 10.1096/Fj.03-1378Fje |
0.41 |
|
| 2004 |
Greig NH, Utsuki T, Wang Y, Ingram DK, Mamczar J, Rogers J, Yun Q, Holloway HW, Perry TA, Sambamurti K, Scali C, Pepeu G, Lahiri DK. P1-414 Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers amyloid-beta peptide in rodents: a new treatment strategy for Alzheimer's disease Neurobiology of Aging. 25: S216. DOI: 10.1016/S0197-4580(04)80726-7 |
0.461 |
|
| 2004 |
Salehi A, Delcroix J, Xia W, Sambamurti K, Mobley WC. P1-254 APP and β-amyloid levels in segmental trisomy mouse model of down syndrome Neurobiology of Aging. 25: S168. DOI: 10.1016/S0197-4580(04)80567-0 |
0.342 |
|
| 2004 |
Lahiri DK, Bailey J, Alley G, Chen D, Sambamurti K, Greig N. O3-06-01 Effects of diverse cholinesterase inhibitors and memantine on the amyloid pathway and its implications in Alzheimer's disease Neurobiology of Aging. 25: S63-S64. DOI: 10.1016/S0197-4580(04)80214-8 |
0.451 |
|
| 2003 |
Marlow L, Cain M, Pappolla MA, Sambamurti K. Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP). Journal of Molecular Neuroscience : Mn. 20: 233-9. PMID 14501002 DOI: 10.1385/Jmn:20:3:233 |
0.696 |
|
| 2003 |
Marlow L, Canet RM, Haugabook SJ, Hardy JA, Lahiri DK, Sambamurti K. APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity. Biochemical and Biophysical Research Communications. 305: 502-9. PMID 12763021 DOI: 10.1016/S0006-291X(03)00797-6 |
0.535 |
|
| 2003 |
Perry T, Lahiri DK, Sambamurti K, Chen D, Mattson MP, Egan JM, Greig NH. Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. Journal of Neuroscience Research. 72: 603-12. PMID 12749025 DOI: 10.1002/Jnr.10611 |
0.444 |
|
| 2003 |
Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB, Thiele DL. Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proceedings of the National Academy of Sciences of the United States of America. 100: 6221-6. PMID 12732730 DOI: 10.1073/Pnas.1031520100 |
0.482 |
|
| 2003 |
Baker LD, Sambamurti K, Craft S, Cherrier M, Raskind MA, Stanczyk FZ, Plymate SR, Asthana S. 17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary study. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 11: 239-44. PMID 12611754 |
0.394 |
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| 2003 |
Lahiri DK, Farlow MR, Sambamurti K, Greig NH, Giacobini E, Schneider LS. A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease. Current Drug Targets. 4: 97-112. PMID 12558063 DOI: 10.2174/1389450033346957 |
0.525 |
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| 2003 |
Eckman EA, Watson M, Marlow L, Sambamurti K, Eckman CB. Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme. The Journal of Biological Chemistry. 278: 2081-4. PMID 12464614 DOI: 10.1074/Jbc.C200642200 |
0.544 |
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| 2003 |
Baker LD, Sambamurti K, Craft S, Cherrier M, Raskind MA, Stanczyk FZ, Plymate SR, Asthana S. 17β-Estradiol Reduces Plasma Aβ40 for HRT-Naïve Postmenopausal Women With Alzheimer Disease: A Preliminary Study The American Journal of Geriatric Psychiatry. 11: 239-244. DOI: 10.1097/00019442-200303000-00015 |
0.374 |
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| 2003 |
Marlow L, Canet RM, Haugabook SJ, Hardy JA, Lahiri DK, Sambamurti K. Addendum “APH1, PEN2, and Nicastrin increase Aβ levels and γ-secretase activity” [Biochem. Biophys. Res. Commun. 305 (2003) 502–509] Biochemical and Biophysical Research Communications. 307: 756. DOI: 10.1016/S0006-291X(03)01247-6 |
0.352 |
|
| 2002 |
Greig NH, Lahiri DK, Sambamurti K. Butyrylcholinesterase: an important new target in Alzheimer's disease therapy. International Psychogeriatrics / Ipa. 14: 77-91. PMID 12636181 DOI: 10.1017/S1041610203008676 |
0.463 |
|
| 2002 |
Lahiri DK, Kotwal GJ, Farlow MR, Sima A, Kupsky W, Sarkar FH, Sambamurti K. The role of the carboxyl-terminal fragments of amyloid precursor protein in Alzheimer's disease. Annals of the New York Academy of Sciences. 973: 334-9. PMID 12485889 DOI: 10.1111/J.1749-6632.2002.Tb04661.X |
0.54 |
|
| 2002 |
Utsuki T, Shoaib M, Holloway HW, Ingram DK, Wallace WC, Haroutunian V, Sambamurti K, Lahiri DK, Greig NH. Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat. Journal of Alzheimer's Disease : Jad. 4: 405-15. PMID 12446972 DOI: 10.3233/Jad-2002-4507 |
0.443 |
|
| 2002 |
Tun H, Marlow L, Pinnix I, Kinsey R, Sambamurti K. Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway. Journal of Molecular Neuroscience : Mn. 19: 31-5. PMID 12212790 DOI: 10.1007/S12031-002-0007-5 |
0.412 |
|
| 2002 |
Sambamurti K, Greig NH, Lahiri DK. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Medicine. 1: 1-31. PMID 12025813 DOI: 10.1385/Nmm:1:1:1 |
0.578 |
|
| 2002 |
Lahiri DK, Farlow MR, Greig NH, Sambamurti K. Current drug targets for Alzheimer's disease treatment Drug Development Research. 56: 267-281. DOI: 10.1002/Ddr.10081 |
0.548 |
|
| 2002 |
Sambamurti K, Hardy J, Refolo LM, Lahiri DK. Targeting APP metabolism for the treatment of Alzheimer's disease Drug Development Research. 56: 211-227. DOI: 10.1002/Ddr.10077 |
0.557 |
|
| 2001 |
Pinnix I, Council JE, Roseberry B, Onstead L, Mallender W, Sucic J, Sambamurti K. Convertases other than furin cleave beta-secretase to its mature form. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 1810-2. PMID 11481238 DOI: 10.1096/Fj.00-0891Fje |
0.395 |
|
| 2001 |
Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, Ge YW, Lahiri DK, Greig NH. Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proceedings of the National Academy of Sciences of the United States of America. 98: 7605-10. PMID 11404470 DOI: 10.1073/Pnas.131152998 |
0.448 |
|
| 2001 |
Mallender WD, Yager D, Onstead L, Nichols MR, Eckman C, Sambamurti K, Kopcho LM, Marcinkeviciene J, Copeland RA, Rosenberry TL. Characterization of recombinant, soluble beta-secretase from an insect cell expression system. Molecular Pharmacology. 59: 619-26. PMID 11179458 DOI: 10.1124/Mol.59.3.619 |
0.511 |
|
| 2001 |
Haugabook SJ, Le T, Yager D, Zenk B, Healy BM, Eckman EA, Prada C, Younkin L, Murphy P, Pinnix I, Onstead L, Sambamurti K, Golde TE, Dickson D, Younkin SG, et al. Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 16-18. PMID 11099491 DOI: 10.1096/Fj.00-0528Fje |
0.539 |
|
| 2001 |
Pinnix I, Musunuru U, Tun H, Sridharan A, Golde T, Eckman C, Ziani-Cherif C, Onstead L, Sambamurti K. A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. The Journal of Biological Chemistry. 276: 481-7. PMID 11035007 DOI: 10.1074/Jbc.M005968200 |
0.393 |
|
| 2000 |
McLendon C, Xin T, Ziani-Cherif C, Murphy MP, Findlay KA, Lewis PA, Pinnix I, Sambamurti K, Wang R, Fauq A, Golde TE. Cell-free assays for gamma-secretase activity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 2383-6. PMID 11024004 DOI: 10.1096/Fj.00-0286Fje |
0.412 |
|
| 2000 |
Refolo LM, Malester B, LaFrancois J, Bryant-Thomas T, Wang R, Tint GS, Sambamurti K, Duff K, Pappolla MA. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiology of Disease. 7: 321-31. PMID 10964604 DOI: 10.1006/Nbdi.2000.0304 |
0.709 |
|
| 2000 |
Greig NH, Yu Q, Utsuki T, Halloway HW, Ingram DK, Haroutinian V, Sambamurti K, Lahiri DK. Novel selective butyrylcholinesterase inhibitors as a new strategy for the treatment of Alzheimer's disease Neurobiology of Aging. 21: 274. DOI: 10.1016/S0197-4580(00)83183-8 |
0.376 |
|
| 2000 |
Refolo LM, Wang R, Tint SG, Sambamurti K, Francois JL, Duff K. Hypercholesterolemia accelerates amyloid pathology in a transgenic mouse model of Alzheimer's amyloidosis Neurobiology of Aging. 21: 125. DOI: 10.1016/S0197-4580(00)82363-5 |
0.506 |
|
| 1999 |
Refolo LM, Eckman C, Prada CM, Yager D, Sambamurti K, Mehta N, Hardy J, Younkin SG. Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells. Journal of Neurochemistry. 73: 2383-8. PMID 10582597 DOI: 10.1046/J.1471-4159.1999.0732383.X |
0.498 |
|
| 1999 |
Sambamurti K, Sevlever D, Koothan T, Refolo LM, Pinnix I, Gandhi S, Onstead L, Younkin L, Prada CM, Yager D, Ohyagi Y, Eckman CB, Rosenberry TL, Younkin SG. Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein. The Journal of Biological Chemistry. 274: 26810-4. PMID 10480887 DOI: 10.1074/Jbc.274.38.26810 |
0.508 |
|
| 1998 |
Lahiri DK, Farlow MR, Sambamurti K. The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells. Brain Research. Molecular Brain Research. 62: 131-40. PMID 9813282 DOI: 10.1016/S0169-328X(98)00236-8 |
0.557 |
|
| 1998 |
Sambamurti K, Lahiri DK. ERAB contains a putative noncleavable signal peptide Biochemical and Biophysical Research Communications. 249: 546-549. PMID 9712734 DOI: 10.1006/Bbrc.1998.9178 |
0.468 |
|
| 1998 |
Tezapsidis N, Li HC, Ripellino JA, Efthimiopoulos S, Vassilacopoulou D, Sambamurti K, Toneff T, Yasothornsrikul S, Hook VY, Robakis NK. Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes. Biochemistry. 37: 1274-82. PMID 9477953 DOI: 10.1021/Bi9714159 |
0.393 |
|
| 1997 |
Lahiri DK, Farlow MR, Sambamurti K, Nall C. The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells. Life Sciences. 61: 1985-92. PMID 9366505 DOI: 10.1016/S0024-3205(97)00868-0 |
0.454 |
|
| 1996 |
Pappolla MA, Sos M, Omar RA, Sambamurti K. The heat shock/oxidative stress connection. Relevance to Alzheimer disease. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 28: 21-34. PMID 8871938 DOI: 10.1007/BF02815201 |
0.605 |
|
| 1996 |
Pappolla M, Sos M, Reiter R, Sambamurti K, Omar R, Robakis N, Efthimiopoulos S. 589 Melatonin prevents oxidative damage and heat-shock protein induction in cultured cells exposed to the Alzheimer's amyloid beta protein (Aβ) Neurobiology of Aging. 17: S146-S147. DOI: 10.1016/S0197-4580(96)80591-4 |
0.664 |
|
| 1996 |
Sambamurti K, McConlogue L, de Wit C, Refolo L. 88 Studies on the role of glycosylation on processing of the Alzheimer amyloid precursor protein (APP) Neurobiology of Aging. 17: S22. DOI: 10.1016/S0197-4580(96)80090-X |
0.422 |
|
| 1995 |
Pappolla MA, Sambamurti K, Efthimiopoulos S, Refolo L, Omar RA, Robakis NK. Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins. Neuroscience Letters. 192: 105-8. PMID 7675314 DOI: 10.1016/0304-3940(95)11627-9 |
0.588 |
|
| 1995 |
Refolo LM, Sambamurti K, Efthimiopoulos S, Pappolla MA, Robakis NK. Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization. Journal of Neuroscience Research. 40: 694-706. PMID 7602619 DOI: 10.1002/Jnr.490400515 |
0.583 |
|
| 1995 |
Ogburn J, Sambamurti K, Wisniewski T, Franuione B, Dudley A, Pappolla M. COLLOID INCLUSIONS OF PARKINSONʼS DISEASE Journal of Neuropathology and Experimental Neurology. 54: 445. DOI: 10.1097/00005072-199505000-00152 |
0.534 |
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| 1994 |
Efthimiopoulos S, Felsenstein KM, Sambamurti K, Robakis NK, Refolo LM. Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. Journal of Neuroscience Research. 38: 81-90. PMID 8057394 DOI: 10.1002/Jnr.490380111 |
0.319 |
|
| 1993 |
Robakis NK, Vassilacopoulou D, Efthimiopoulos S, Sambamurti K, Refolo LM, Shioi J. Cellular processing and proteoglycan nature of amyloid precursor proteins. Annals of the New York Academy of Sciences. 695: 132-8. PMID 8239271 DOI: 10.1111/J.1749-6632.1993.Tb23041.X |
0.4 |
|
| 1992 |
Sambamurti K, Shioi J, Anderson JP, Pappolla MA, Robakis NK. Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. Journal of Neuroscience Research. 33: 319-29. PMID 1453494 DOI: 10.1002/jnr.490330216 |
0.618 |
|
| 1992 |
Sambamurti K, Refolo LM, Shioi J, Pappolla MA, Robakis NK. The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment. Annals of the New York Academy of Sciences. 674: 118-28. PMID 1283818 DOI: 10.1111/j.1749-6632.1992.tb27481.x |
0.634 |
|
| 1991 |
Anderson JP, Esch FS, Keim PS, Sambamurti K, Lieberburg I, Robakis NK. Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neuroscience Letters. 128: 126-8. PMID 1922940 DOI: 10.1016/0304-3940(91)90775-O |
0.447 |
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