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Sergei Y. Fuchs - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Fuchs SY, et al. SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway. Journal of Virology. JVI0086221. PMID 34260266 DOI: 10.1128/JVI.00862-21  0.338
2021 Alicea-Torres K, Sanseviero E, Gui J, Chen J, Veglia F, Yu Q, Donthireddy L, Kossenkov A, Lin C, Fu S, Mulligan C, Nam B, Masters G, Denstman F, Bennett J, ... ... Fuchs SY, et al. Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway. Nature Communications. 12: 1717. PMID 33741967 DOI: 10.1038/s41467-021-22033-2  0.301
2019 Gui J, Katlinski KV, Koumenis C, Diehl JA, Fuchs SY. The PKR-like endoplasmic reticulum kinase promotes the dissemination of Myc-induced leukemic cells. Molecular Cancer Research : McR. PMID 30902831 DOI: 10.1158/1541-7786.Mcr-19-0002  0.377
2017 Gui J, Zhao B, Lyu K, Tong W, Fuchs SY. Downregulation of the IFNAR1 chain of type 1 interferon receptor contributes to the maintenance of the hematopoietic stem cells. Cancer Biology & Therapy. 0. PMID 28678581 DOI: 10.1080/15384047.2017.1345395  0.35
2017 Zhao B, Bhattacharya S, Yu Q, Fuchs SY. Expression of the IFNAR1 chain of type 1 interferon receptor in benign cells protects against progression of acute leukemia. Leukemia & Lymphoma. 1-7. PMID 28503979 DOI: 10.1080/10428194.2017.1319053  0.325
2016 Katlinskaya YV, Katlinski KV, Yu Q, Ortiz A, Beiting DP, Brice A, Davar D, Sanders C, Kirkwood JM, Rui H, Xu X, Koumenis C, Diehl JA, Fuchs SY. Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression. Cell Reports. PMID 27052162 DOI: 10.1016/J.Celrep.2016.03.006  0.328
2015 Xia C, Vijayan M, Pritzl CJ, Fuchs SY, McDermott AB, Hahm B. Hemagglutinin of influenza A virus antagonizes type I IFN responses by inducing degradation of type I IFN receptor 1. Journal of Virology. PMID 26676772 DOI: 10.1128/JVI.02749-15  0.313
2014 Carbone CJ, Fuchs SY. Eliminative signaling by Janus kinases: role in the downregulation of associated receptors. Journal of Cellular Biochemistry. 115: 8-16. PMID 23959845 DOI: 10.1002/Jcb.24647  0.371
2013 Bhattacharya S, HuangFu WC, Dong G, Qian J, Baker DP, Karar J, Koumenis C, Diehl JA, Fuchs SY. Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses. Oncogene. 32: 4214-21. PMID 23045272 DOI: 10.1038/onc.2012.439  0.448
2013 Koumenis C, Hart LS, Cunningham T, Dey S, Tameire F, Mills I, Ruggero D, Diehl AJ, Fuchs S. Abstract SY32-04: The translation initiation factor elF2α regulates cytoprotective autophagy in Myc-dependent lymphoma. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Sy32-04  0.331
2012 Carbone CJ, Zheng H, Bhattacharya S, Lewis JR, Reiter AM, Henthorn P, Zhang ZY, Baker DP, Ukkiramapandian R, Bence KK, Fuchs SY. Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies. Proceedings of the National Academy of Sciences of the United States of America. 109: 19226-31. PMID 23129613 DOI: 10.1073/Pnas.1211491109  0.399
2012 Huangfu WC, Qian J, Liu C, Liu J, Lokshin AE, Baker DP, Rui H, Fuchs SY. Inflammatory signaling compromises cell responses to interferon alpha. Oncogene. 31: 161-72. PMID 21666722 DOI: 10.1038/Onc.2011.221  0.376
2011 Zheng H, Qian J, Baker DP, Fuchs SY. Tyrosine phosphorylation of protein kinase D2 mediates ligand-inducible elimination of the Type 1 interferon receptor. The Journal of Biological Chemistry. 286: 35733-41. PMID 21865166 DOI: 10.1074/jbc.M111.263608  0.423
2011 Bhattacharya S, Zheng H, Tzimas C, Carroll M, Baker DP, Fuchs SY. Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor. Blood. 118: 4179-87. PMID 21821707 DOI: 10.1182/Blood-2010-12-325373  0.373
2011 Qian J, Zheng H, Huangfu WC, Liu J, Carbone CJ, Leu NA, Baker DP, Fuchs SY. Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1. Plos Pathogens. 7: e1002065. PMID 21695243 DOI: 10.1371/Journal.Ppat.1002065  0.372
2011 Bhattacharya S, Qian J, Tzimas C, Baker DP, Koumenis C, Diehl JA, Fuchs SY. Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor. The Journal of Biological Chemistry. 286: 22069-76. PMID 21540188 DOI: 10.1074/Jbc.M111.238766  0.441
2011 Zheng H, Qian J, Varghese B, Baker DP, Fuchs S. Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2. Molecular and Cellular Biology. 31: 710-20. PMID 21173164 DOI: 10.1128/Mcb.01154-10  0.408
2010 HuangFu WC, Qian J, Liu C, Rui H, Fuchs SY. Melanoma cell-secreted soluble factor that stimulates ubiquitination and degradation of the interferon alpha receptor and attenuates its signaling. Pigment Cell & Melanoma Research. 23: 838-40. PMID 21644263 DOI: 10.1111/J.1755-148X.2010.00770.X  0.363
2010 Varghese B, Swaminathan G, Plotnikov A, Tzimas C, Yang N, Rui H, Fuchs SY. Prolactin inhibits activity of pyruvate kinase M2 to stimulate cell proliferation. Molecular Endocrinology (Baltimore, Md.). 24: 2356-65. PMID 20962042 DOI: 10.1210/Me.2010-0219  0.369
2010 Bhattacharya S, HuangFu WC, Liu J, Veeranki S, Baker DP, Koumenis C, Diehl JA, Fuchs SY. Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor. The Journal of Biological Chemistry. 285: 2318-25. PMID 19948722 DOI: 10.1074/Jbc.M109.071498  0.468
2010 Fuchs SY. SS10-2 Phosphorylation-dependent regulation of IFNAR1 stability and signaling Cytokine. 52: 78. DOI: 10.1016/j.cyto.2010.07.324  0.33
2010 Zheng H, Qian J, Varghese B, Baker DP, Fuchs S. PS2-36 Limiting cellular responses to interferon alpha: Role of protein kinase D2 Cytokine. 52: 58. DOI: 10.1016/J.Cyto.2010.07.241  0.311
2009 Liu J, Carvalho LP, Bhattacharya S, Carbone CJ, Kumar KG, Leu NA, Yau PM, Donald RG, Weiss MJ, Baker DP, McLaughlin KJ, Scott P, Fuchs SY. Mammalian casein kinase 1alpha and its leishmanial ortholog regulate stability of IFNAR1 and type I interferon signaling. Molecular and Cellular Biology. 29: 6401-12. PMID 19805514 DOI: 10.1128/Mcb.00478-09  0.427
2009 Liu J, HuangFu WC, Kumar KG, Qian J, Casey JP, Hamanaka RB, Grigoriadou C, Aldabe R, Diehl JA, Fuchs SY. Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. Cell Host & Microbe. 5: 72-83. PMID 19154989 DOI: 10.1016/J.Chom.2008.11.008  0.398
2008 Kumar KG, Varghese B, Banerjee A, Baker DP, Constantinescu SN, Pellegrini S, Fuchs SY. Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif. The Journal of Biological Chemistry. 283: 18566-72. PMID 18474601 DOI: 10.1074/Jbc.M800991200  0.329
2008 Plotnikov A, Li Y, Tran TH, Tang W, Palazzo JP, Rui H, Fuchs SY. Oncogene-mediated inhibition of glycogen synthase kinase 3 beta impairs degradation of prolactin receptor. Cancer Research. 68: 1354-61. PMID 18316598 DOI: 10.1158/0008-5472.Can-07-6094  0.323
2008 Swaminathan G, Varghese B, Thangavel C, Carbone CJ, Plotnikov A, Kumar KG, Jablonski EM, Clevenger CV, Goffin V, Deng L, Frank SJ, Fuchs SY. Prolactin stimulates ubiquitination, initial internalization, and degradation of its receptor via catalytic activation of Janus kinase 2. The Journal of Endocrinology. 196: R1-7. PMID 18252943 DOI: 10.1677/Joe-07-0554  0.414
2008 Liu J, Plotnikov A, Banerjee A, Suresh Kumar KG, Ragimbeau J, Marijanovic Z, Baker DP, Pellegrini S, Fuchs SY. Ligand-independent pathway that controls stability of interferon alpha receptor. Biochemical and Biophysical Research Communications. 367: 388-93. PMID 18166147 DOI: 10.1016/j.bbrc.2007.12.137  0.429
2008 Liu J, HuangFu W, Kumar KGS, Casey JP, Hamanaka R, Grigoriadou C, Aldabe R, Diehl JA, Fuchs SY. 371 Virus-induced unfolded protein response attenuates anti-viral defenses via phosphorylation-dependent ubiquitination and degradation of Type I interferon receptor Cytokine. 43: 331-331. DOI: 10.1016/J.Cyto.2008.07.456  0.307
2007 Kumar KG, Barriere H, Carbone CJ, Liu J, Swaminathan G, Xu P, Li Y, Baker DP, Peng J, Lukacs GL, Fuchs SY. Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis. The Journal of Cell Biology. 179: 935-50. PMID 18056411 DOI: 10.1083/Jcb.200706034  0.336
2007 Kumar KG, Liu J, Li Y, Yu D, Thomas-Tikhonenko A, Herlyn M, Fuchs SY. Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells. Cancer Biology & Therapy. 6: 1437-41. PMID 17873516 DOI: 10.4161/Cbt.6.9.4569  0.387
2007 Deng L, He K, Wang X, Yang N, Thangavel C, Jiang J, Fuchs SY, Frank SJ. Determinants of growth hormone receptor down-regulation. Molecular Endocrinology (Baltimore, Md.). 21: 1537-51. PMID 17488973 DOI: 10.1210/Me.2007-0138  0.376
2007 Liu J, Kumar KGS, Carvalho L, Donald RGK, Scott P, Fuchs SY. 89 Regulation of Type I Interferon Receptor Stability and Signaling by Casein Kinase 1-alpha and its Leishmania Orthologue Cytokine. 39: 25-25. DOI: 10.1016/J.Cyto.2007.07.094  0.391
2006 Malakhova OA, Kim KI, Luo JK, Zou W, Kumar KG, Fuchs SY, Shuai K, Zhang DE. UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. The Embo Journal. 25: 2358-67. PMID 16710296 DOI: 10.1038/Sj.Emboj.7601149  0.356
2006 Marijanovic Z, Ragimbeau J, Kumar KG, Fuchs SY, Pellegrini S. TYK2 activity promotes ligand-induced IFNAR1 proteolysis. The Biochemical Journal. 397: 31-8. PMID 16551269 DOI: 10.1042/BJ20060272  0.421
2004 Kumar KG, Krolewski JJ, Fuchs SY. Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor. The Journal of Biological Chemistry. 279: 46614-20. PMID 15337770 DOI: 10.1074/Jbc.M407082200  0.375
2004 Li Y, Kumar KG, Tang W, Spiegelman VS, Fuchs SY. Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase. Molecular and Cellular Biology. 24: 4038-48. PMID 15082796 DOI: 10.1128/MCB.24.9.4038-4048.2004  0.345
2003 Kumar KG, Tang W, Ravindranath AK, Clark WA, Croze E, Fuchs SY. SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. The Embo Journal. 22: 5480-90. PMID 14532120 DOI: 10.1093/emboj/cdg524  0.414
2002 Spiegelman VS, Tang W, Chan AM, Igarashi M, Aaronson SA, Sassoon DA, Katoh M, Slaga TJ, Fuchs SY. Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling. The Journal of Biological Chemistry. 277: 36624-30. PMID 12151397 DOI: 10.1074/Jbc.M204524200  0.332
2001 Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, Gaarde WA, Holbrook NJ, Shiloh Y, Ronai Z. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Molecular and Cellular Biology. 21: 2743-54. PMID 11283254 DOI: 10.1128/MCB.21.8.2743-2754.2001  0.316
2000 Fuchs SY, Tappin I, Ronai Z. Stability of the ATF2 transcription factor is regulated by phosphorylation and dephosphorylation. The Journal of Biological Chemistry. 275: 12560-4. PMID 10777545 DOI: 10.1074/Jbc.275.17.12560  0.405
1999 Adler V, Yin Z, Fuchs SY, Benezra M, Rosario L, Tew KD, Pincus MR, Sardana M, Henderson CJ, Wolf CR, Davis RJ, Ronai Z. Regulation of JNK signaling by GSTp. The Embo Journal. 18: 1321-34. PMID 10064598 DOI: 10.1093/Emboj/18.5.1321  0.359
1998 Fuchs SY, Fried VA, Ronai Z. Stress-activated kinases regulate protein stability. Oncogene. 17: 1483-90. PMID 9779995 DOI: 10.1038/Sj.Onc.1202184  0.359
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