| Year |
Citation |
Score |
| 2023 |
Li Y, Eans SO, Ganno-Sherwood M, Eliasof A, Houghten RA, McLaughlin JP. Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide. Molecules (Basel, Switzerland). 28. PMID 38005269 DOI: 10.3390/molecules28227548 |
0.393 |
|
| 2023 |
Scherrer KH, Eans SO, Medina JM, Senadheera SN, Khaliq T, Murray TF, McLaughlin JP, Aldrich JV. Tryptophan Substitution in CJ-15,208 ([Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference. Pharmaceuticals (Basel, Switzerland). 16. PMID 37765026 DOI: 10.3390/ph16091218 |
0.74 |
|
| 2023 |
Rayala R, Tiller A, Majumder SA, Stacy HM, Eans SO, Nedovic A, McLaughlin JP, Cudic P. Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration. Molecules (Basel, Switzerland). 28. PMID 36838810 DOI: 10.3390/molecules28041822 |
0.722 |
|
| 2022 |
Zhu J, Quizon PM, Wang Y, Adeniran CA, Strauss MJ, Torres AJ, Patel P, Cirino TJ, Eans SO, Hammond HR, Deliscar LS, O'Hara P, Saini SK, Ofori E, Vekariya RH, ... ... McLaughlin JP, et al. SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice. Neuropharmacology. 109239. PMID 36126727 DOI: 10.1016/j.neuropharm.2022.109239 |
0.799 |
|
| 2022 |
McLaughlin JP, Rayala R, Bunnell AJ, Tantak MP, Eans SO, Nefzi K, Ganno ML, Dooley CT, Nefzi A. Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics. International Journal of Molecular Sciences. 23. PMID 36077029 DOI: 10.3390/ijms23179623 |
0.419 |
|
| 2022 |
Wilson LL, Alleyne AR, Eans SO, Cirino TJ, Stacy HM, Mottinelli M, Intagliata S, McCurdy CR, McLaughlin JP. Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain. Molecules (Basel, Switzerland). 27. PMID 35684553 DOI: 10.3390/molecules27113617 |
0.781 |
|
| 2022 |
Brice-Tutt AC, Eans SO, Yakovlev D, Aldrich JV, McLaughlin JP. An analog of [d-Trp]CJ-15,208 exhibits kappa opioid receptor antagonism following oral administration and prevents stress-induced reinstatement of extinguished morphine conditioned place preference. Pharmacology, Biochemistry, and Behavior. 217: 173405. PMID 35584724 DOI: 10.1016/j.pbb.2022.173405 |
0.837 |
|
| 2022 |
Zhang P, Guergues J, Alleyne AR, Cirino TJ, Nadeau O, Figueroa AM, Stacy HM, Suzuki T, McLaughlin JP, Stevens SM, Liu B. Novel Histone Modifications in Microglia Derived from a Mouse Model of Chronic Pain. Proteomics. e2100137. PMID 35081661 DOI: 10.1002/pmic.202100137 |
0.77 |
|
| 2022 |
Wilson LL, Eans SO, Ramadan-Siraj I, Modica MN, Romeo G, Intagliata S, McLaughlin JP. Examination of the Novel Sigma-1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti-allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use. International Journal of Molecular Sciences. 23. PMID 35054797 DOI: 10.3390/ijms23020615 |
0.61 |
|
| 2021 |
Chakraborty S, Uprety R, Slocum ST, Irie T, Le Rouzic V, Li X, Wilson LL, Scouller B, Alder AF, Kruegel AC, Ansonoff M, Varadi A, Eans SO, Hunkele A, Allaoa A, ... ... McLaughlin JP, et al. Oxidative Metabolism as a Modulator of Kratom's Biological Actions. Journal of Medicinal Chemistry. PMID 34783240 DOI: 10.1021/acs.jmedchem.1c01111 |
0.643 |
|
| 2021 |
Chakraborty S, DiBerto JF, Faouzi A, Bernhard SM, Gutridge AM, Ramsey S, Zhou Y, Provasi D, Nuthikattu N, Jilakara R, Nelson MNF, Asher WB, Eans SO, Wilson LL, Chintala SM, ... ... McLaughlin JP, et al. A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. Journal of Medicinal Chemistry. PMID 34505767 DOI: 10.1021/acs.jmedchem.1c01273 |
0.662 |
|
| 2021 |
Aldrich JV, McLaughlin JP. Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development. Handbook of Experimental Pharmacology. PMID 34463847 DOI: 10.1007/164_2021_519 |
0.7 |
|
| 2021 |
Chakraborty S, Uprety R, Daibani AE, Rouzic VL, Hunkele A, Appourchaux K, Eans SO, Nuthikattu N, Jilakara R, Thammavong L, Pasternak GW, Pan YX, McLaughlin JP, Che T, Majumdar S. Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom. Acs Chemical Neuroscience. PMID 34213886 DOI: 10.1021/acschemneuro.1c00149 |
0.412 |
|
| 2021 |
Romeo G, Bonanno F, Wilson LL, Arena E, Modica MN, Pittalà V, Salerno L, Prezzavento O, McLaughlin JP, Intagliata S. Development of New Benzylpiperazine Derivatives as σ Receptor Ligands with Antinociceptive and Anti-Allodynic Effects. Acs Chemical Neuroscience. PMID 34019387 DOI: 10.1021/acschemneuro.1c00106 |
0.626 |
|
| 2021 |
Kandasamy R, Hillhouse TM, Livingston KE, Kochan KE, Meurice C, Eans SO, Li MH, White AD, Roques BP, McLaughlin JP, Ingram SL, Burford NT, Alt A, Traynor JR. Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33846240 DOI: 10.1073/pnas.2000017118 |
0.52 |
|
| 2021 |
Cirino TJ, McLaughlin JP. Mini review: Promotion of substance abuse in HIV patients: Biological mediation by HIV-1 Tat protein. Neuroscience Letters. 135877. PMID 33838257 DOI: 10.1016/j.neulet.2021.135877 |
0.798 |
|
| 2021 |
Paris JJ, Chen X, Anderson J, Qrareya AN, Mahdi F, Du F, McLaughlin JP, Kaufman MJ. In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain. Geroscience. PMID 33818687 DOI: 10.1007/s11357-021-00354-w |
0.64 |
|
| 2021 |
Cirino TJ, Alleyne AR, Duarte V, Figueroa A, Simons CA, Anceaume EM, Kendrick J, Wallman O, Eans SO, Stacy HM, Medina JM, McLaughlin JP. Expression of Human Immunodeficiency Virus Transactivator of Transcription (HIV-Tat) Protein Alters Nociceptive Processing that is Sensitive to Anti-Oxidant and Anti-Inflammatory Interventions. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 33619645 DOI: 10.1007/s11481-021-09985-4 |
0.788 |
|
| 2021 |
Uprety R, Che T, Zaidi SA, Grinnell SG, Varga BR, Faouzi A, Slocum ST, Allaoa A, Varadi A, Nelson M, Bernhard SM, Kulko E, LeRouzic V, Eans SO, Simons CA, ... ... McLaughlin JP, et al. Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site. Elife. 10. PMID 33555255 DOI: 10.7554/eLife.56519 |
0.376 |
|
| 2021 |
Wilson LL, Chakraborty S, Eans SO, Cirino TJ, Stacy HM, Simons CA, Uprety R, Majumdar S, McLaughlin JP. Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal. Cellular and Molecular Neurobiology. PMID 33433723 DOI: 10.1007/s10571-020-01034-7 |
0.83 |
|
| 2020 |
Wilson LL, Harris HM, Eans SO, Brice-Tutt AC, Cirino TJ, Stacy HM, Simons CA, León F, Sharma A, Boyer EW, Avery BA, McLaughlin JP, McCurdy CR. Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence. Drug and Alcohol Dependence. 216: 108310. PMID 33017752 DOI: 10.1016/j.drugalcdep.2020.108310 |
0.79 |
|
| 2020 |
Sivalingam K, Cirino TJ, McLaughlin JP, Samikkannu T. HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration. Molecular Neurobiology. PMID 32978730 DOI: 10.1007/s12035-020-02131-w |
0.791 |
|
| 2020 |
Brice-Tutt AC, Senadheera SN, Ganno ML, Eans SO, Khaliq T, Murray TF, McLaughlin JP, Aldrich JV. Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles. Molecules (Basel, Switzerland). 25. PMID 32887303 DOI: 10.3390/Molecules25173999 |
0.814 |
|
| 2020 |
Intagliata S, Sharma A, King TI, Mesangeau C, Seminerio M, Chin FT, Wilson LL, Matsumoto RR, McLaughlin JP, Avery BA, McCurdy CR. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. The Aaps Journal. 22: 94. PMID 32691179 DOI: 10.1208/S12248-020-00472-X |
0.656 |
|
| 2020 |
Brice-Tutt AC, Wilson LL, Eans SO, Stacy HM, Simons CA, Simpson GG, Coleman JS, Ferracane MJ, Aldrich JV, McLaughlin JP. Multifunctional Opioid Receptor Agonism and Antagonism by a Novel Macrocyclic Tetrapeptide Prevents Reinstatement of Morphine-Seeking Behavior. British Journal of Pharmacology. PMID 32562259 DOI: 10.1111/Bph.15165 |
0.828 |
|
| 2020 |
Ferracane MJ, Brice-Tutt A, Coleman J, Simpson G, Wilson L, Eans SO, Stacy H, Murray TF, McLaughlin JP, Aldrich JV. Design, Synthesis, and Characterization of the Macrocyclic Tetrapeptide [Pro-Sar-Phe-D-Phe]: a Mixed Opioid Receptor Agonist-Antagonist Following Oral Administration. Acs Chemical Neuroscience. PMID 32251585 DOI: 10.1021/Acschemneuro.0C00086 |
0.822 |
|
| 2020 |
Cirino TJ, Harden SW, McLaughlin JP, Frazier CJ. Region-specific effects of HIV-1 Tat on intrinsic electrophysiological properties of pyramidal neurons in mouse prefrontal cortex and hippocampus. Journal of Neurophysiology. PMID 32101482 DOI: 10.1152/Jn.00029.2020 |
0.786 |
|
| 2020 |
Norwood VM, Brice-Tutt A, Eans SO, Stacy H, Shi G, Ratnayake R, Rocca JR, Abboud KA, Li C, Luesch H, McLaughlin JP, Huigens Iii RW. Preventing Morphine Seeking Behavior through the Re-engineering of Vincamine's Biological Activity. Journal of Medicinal Chemistry. PMID 31913038 DOI: 10.1021/Acs.Jmedchem.9B01924 |
0.83 |
|
| 2020 |
Faouzi A, Zaidi S, Che T, Kormos C, Zhang T, Madasu M, Eans S, Simons C, Pan Y, McLaughlin J, Carroll I, Hassani RA, Roth B, Katritch V, Majumdar S. Design of first in class bitopic ligands targeting the sodium binding pocket in opioid receptors The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02437 |
0.375 |
|
| 2020 |
Norwood V, Brice-Tutt AC, Eans SO, Stacy HM, Shi G, Ratnayake R, Rocca JR, Abboud KA, Li C, Luesch H, McLaughlin JP, Huigens RW. Preventing Morphine-SeekingBehavior through the Re-Engineeringof Vincamine’s Biological Activity Journal of Medicinal Chemistry. DOI: 10.1021/Acs.Jmedchem.9B01924.S001 |
0.5 |
|
| 2019 |
Cirino TJ, Eans SO, Medina JM, Wilson LL, Mottinelli M, Intagliata S, McCurdy CR, McLaughlin JP. Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain. Frontiers in Pharmacology. 10: 678. PMID 31258480 DOI: 10.3389/Fphar.2019.00678 |
0.818 |
|
| 2019 |
Harris HM, Eans SO, Ganno ML, Davis JC, Dooley CT, McLaughlin JP, Nefzi A. Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs. Organic & Biomolecular Chemistry. PMID 31094391 DOI: 10.1039/C9Ob00882A |
0.503 |
|
| 2018 |
Miller DR, Shaerzadeh F, Phan L, Sharif N, Gamble-George J, McLaughlin JP, Streit WJ, Khoshbouei H. HIV-1 Tat regulation of dopamine transmission and microglial reactivity is brain region specific. Glia. PMID 29733459 DOI: 10.1002/Glia.23447 |
0.323 |
|
| 2017 |
McLaughlin JP, Paris JJ, Mintzopoulos D, Hymel KA, Kim JK, Cirino TJ, Gillis TE, Eans SO, Vitaliano GD, Medina JM, Krapf RC, Stacy HM, Kaufman MJ. Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 2: 599-609. PMID 29057370 DOI: 10.1016/J.Bpsc.2017.04.002 |
0.779 |
|
| 2017 |
Shao J, Houghten RA, Dooley CT, Cazares M, McLaughlin JP, Eans SO, Ganno ML, Hoot MR, Giulianotti MA, Yu Y. A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation. Organic & Biomolecular Chemistry. PMID 28875208 DOI: 10.1039/C7Ob01924F |
0.369 |
|
| 2017 |
Spetea M, Eans SO, Ganno ML, Lantero A, Mairegger M, Toll L, Schmidhammer H, McLaughlin JP. Selective κ opioid receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice. British Journal of Pharmacology. PMID 28494108 DOI: 10.1111/Bph.13854 |
0.495 |
|
| 2017 |
McLaughlin JP, Eans S, Medina J, Hymel K, Rock A, Mintzopoulos D, Kaufman MJ. HIV-1 Tat-protein elevates forebrain glutathione levels and increases morphine drug-seeking and depression-like behaviors in mice Drug and Alcohol Dependence. 171: e139. DOI: 10.1016/J.Drugalcdep.2016.08.386 |
0.41 |
|
| 2016 |
Váradi A, Marrone GF, Palmer TC, Narayan A, Szabó MR, Le Rouzic V, Grinnell SG, Subrath JJ, Warner E, Kalra S, Hunkele A, Pagirsky J, Eans SO, Medina JM, Xu J, ... ... McLaughlin JP, et al. Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism which do not recruit β-arrestin-2. Journal of Medicinal Chemistry. PMID 27556704 DOI: 10.1021/Acs.Jmedchem.6B00748 |
0.505 |
|
| 2016 |
Smeets CJ, Zmorzyńska J, Melo MN, Stargardt A, Dooley C, Bakalkin G, McLaughlin J, Sinke RJ, Marrink SJ, Reits E, Verbeek DS. Altered secondary structure of Dynorphin A associates with loss of opioid signalling and NMDA-mediated excitotoxicity in SCA23. Human Molecular Genetics. PMID 27260403 DOI: 10.1093/Hmg/Ddw130 |
0.427 |
|
| 2016 |
Hymel KA, Paris JJ, McLaughlin JP. Modulation of Opioid Analgesic Reward by Inflammatory Agents Neuropathology of Drug Addictions and Substance Misuse. 3: 545-554. DOI: 10.1016/B978-0-12-800634-4.00055-X |
0.694 |
|
| 2015 |
Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. Direct High Throughput In Vivo Screening: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine bis-Piperazines. Acs Combinatorial Science. PMID 26651386 DOI: 10.1021/Acscombsci.5B00126 |
0.305 |
|
| 2015 |
Mediouni S, Garibaldi Marcondes MC, Miller C, McLaughlin JP, Valente ST. The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders. Frontiers in Microbiology. 6: 1164. PMID 26557111 DOI: 10.3389/Fmicb.2015.01164 |
0.35 |
|
| 2015 |
Váradi A, Marrone GF, Eans SO, Ganno ML, Subrath JJ, Le Rouzic V, Hunkele A, Pasternak GW, McLaughlin JP, Majumdar S. Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior. Acs Chemical Neuroscience. PMID 26325040 DOI: 10.1021/Acschemneuro.5B00153 |
0.531 |
|
| 2015 |
Paris JJ, Singh HD, Carey AN, McLaughlin JP. Exposure to HIV-1 Tat in brain impairs sensorimotor gating and activates microglia in limbic and extralimbic brain regions of male mice. Behavioural Brain Research. 291: 209-18. PMID 26005128 DOI: 10.1016/J.Bbr.2015.05.021 |
0.789 |
|
| 2015 |
Eans SO, Ganno ML, Mizrachi E, Houghten RA, Dooley CT, McLaughlin JP, Nefzi A. Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors. Journal of Medicinal Chemistry. 58: 4905-17. PMID 25996309 DOI: 10.1021/Jm501637C |
0.523 |
|
| 2015 |
McLaughlin JP, Paris JJ. Contribution of HIV-Tat protein to HIV-sequelae. Current Hiv Research. 13: 2. PMID 25817718 DOI: 10.2174/1570162X1301150317101233 |
0.63 |
|
| 2015 |
Carey AN, Liu X, Mintzopoulos D, Paris JJ, McLaughlin JP, Kaufman MJ. Conditional Tat protein brain expression in the GT-tg bigenic mouse induces cerebral fractional anisotropy abnormalities. Current Hiv Research. 13: 3-9. PMID 25619988 DOI: 10.2174/1570162X13666150126125244 |
0.782 |
|
| 2015 |
Mediouni S, Jablonski J, Paris JJ, Clementz MA, Thenin-Houssier S, McLaughlin JP, Valente ST. Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice. Current Hiv Research. 13: 64-79. PMID 25613133 DOI: 10.2174/1570162X13666150121111548 |
0.683 |
|
| 2015 |
Hu M, Giulianotti MA, McLaughlin JP, Shao J, Debevec G, Maida LE, Geer P, Cazares M, Misler J, Li L, Dooley C, Ganno ML, Eans SO, Mizrachi E, Santos RG, et al. Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities. European Journal of Medicinal Chemistry. 92: 270-81. PMID 25559207 DOI: 10.1016/J.Ejmech.2014.12.049 |
0.465 |
|
| 2015 |
McLaughlin JP, Ganno ML, Paris JJ, Zhang Y, Kreek MJ. Exposure to HIV-1 Tat protein potentiates the rewarding effects of morphine and reinstates extinguished conditioned place preference Drug and Alcohol Dependence. 156: e147. DOI: 10.1016/J.Drugalcdep.2015.07.401 |
0.736 |
|
| 2015 |
Eans S, Ganno M, Mizrachi E, Senadheera S, Aldrich J, McLaughlin J. Influence of stereochemistry in the macrocyclic tetrapeptide CJ-15,208 on antinociceptive efficacy and opioid receptor selectivity Drug and Alcohol Dependence. 156: e62. DOI: 10.1016/J.Drugalcdep.2015.07.1086 |
0.457 |
|
| 2014 |
McLaughlin JP, Paris JJ. Contribution of HIV-Tat protein to HIV-sequelae (part 1). Current Hiv Research. 12: 377. PMID 25781162 DOI: 10.2174/1570162X1206150311152342 |
0.63 |
|
| 2014 |
McLaughlin JP, Ganno ML, Eans SO, Mizrachi E, Paris JJ. HIV-1 Tat protein exposure potentiates ethanol reward and reinstates extinguished ethanol-conditioned place preference. Current Hiv Research. 12: 415-23. PMID 25760047 DOI: 10.2174/1570162X1206150311160133 |
0.671 |
|
| 2014 |
Paris JJ, Fenwick J, McLaughlin JP. Estrous cycle and HIV-1 Tat protein influence cocaine-conditioned place preference and induced locomotion of female mice. Current Hiv Research. 12: 388-96. PMID 25613137 DOI: 10.2174/1570162X13666150121105221 |
0.674 |
|
| 2014 |
Journigan VB, Mésangeau C, Vyas N, Eans SO, Cutler SJ, McLaughlin JP, Mollereau C, McCurdy CR. Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors. Journal of Medicinal Chemistry. 57: 8903-27. PMID 25268943 DOI: 10.1021/Jm500989N |
0.368 |
|
| 2014 |
Hymel KA, Eans SO, L Sitchenko K, Gomes SM, Lukowsky AL, Medina JM, Sypek EI, Carey AN, McLaughlin JP. Stress-induced increases in depression-like and cocaine place-conditioned behaviors are reversed by disruption of memories during reconsolidation. Behavioural Pharmacology. 25: 599-608. PMID 25083575 DOI: 10.1097/Fbp.0000000000000074 |
0.707 |
|
| 2014 |
Paris JJ, Fenwick J, McLaughlin JP. Progesterone protects normative anxiety-like responding among ovariectomized female mice that conditionally express the HIV-1 regulatory protein, Tat, in the CNS. Hormones and Behavior. 65: 445-53. PMID 24726788 DOI: 10.1016/J.Yhbeh.2014.04.001 |
0.662 |
|
| 2014 |
Aldrich JV, Senadheera SN, Ross NC, Reilley KA, Ganno ML, Eans SE, Murray TF, McLaughlin JP. Alanine analogues of [D-Trp]CJ-15,208: novel opioid activity profiles and prevention of drug- and stress-induced reinstatement of cocaine-seeking behaviour. British Journal of Pharmacology. 171: 3212-22. PMID 24588614 DOI: 10.1111/Bph.12664 |
0.694 |
|
| 2014 |
Paris JJ, Singh HD, Ganno ML, Jackson P, McLaughlin JP. Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat. Psychopharmacology. 231: 2349-60. PMID 24352568 DOI: 10.1007/S00213-013-3385-1 |
0.647 |
|
| 2014 |
Paris JJ, Carey AN, Shay CF, Gomes SM, He JJ, McLaughlin JP. Effects of conditional central expression of HIV-1 tat protein to potentiate cocaine-mediated psychostimulation and reward among male mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 380-8. PMID 23945478 DOI: 10.1038/Npp.2013.201 |
0.804 |
|
| 2014 |
Paris JJ, Carey A, McLaughlin JP. Cocaine-seeking is dose dependently enhanced by HIV-1 tat protein expression in male and female mice Drug and Alcohol Dependence. 140: e168. DOI: 10.1016/J.Drugalcdep.2014.02.473 |
0.749 |
|
| 2014 |
McLaughlin JP, Ganno M, Eans S, Paris JJ, Singh H. HIV-1 tat protein expression in mouse brain potentiates ethanol reward and reinstates extinguished ethanol-seeking behavior Drug and Alcohol Dependence. 140: e141-e142. DOI: 10.1016/J.Drugalcdep.2014.02.401 |
0.636 |
|
| 2014 |
Eans S, Ganno M, Mizrachi E, Senadheera S, Aldrich J, McLaughlin JP. Development of mixed opioid agonist/antagonists to prevent reinstatement of extinguished cocaine-seeking behavior Drug and Alcohol Dependence. 140: e53-e54. DOI: 10.1016/J.Drugalcdep.2014.02.166 |
0.713 |
|
| 2013 |
Patkar KA, Wu J, Ganno ML, Singh HD, Ross NC, Rasakham K, Toll L, McLaughlin JP. Physical presence of nor-binaltorphimine in mouse brain over 21 days after a single administration corresponds to its long-lasting antagonistic effect on κ-opioid receptors. The Journal of Pharmacology and Experimental Therapeutics. 346: 545-54. PMID 23853171 DOI: 10.1124/Jpet.113.206086 |
0.804 |
|
| 2013 |
Eans SO, Ganno ML, Reilley KJ, Patkar KA, Senadheera SN, Aldrich JV, McLaughlin JP. The macrocyclic tetrapeptide [D-Trp]CJ-15,208 produces short-acting κ opioid receptor antagonism in the CNS after oral administration. British Journal of Pharmacology. 169: 426-36. PMID 23425081 DOI: 10.1111/Bph.12132 |
0.709 |
|
| 2013 |
Paris JJ, Eans SO, Mizrachi E, Reilley KJ, Ganno ML, McLaughlin JP. Central administration of angiotensin IV rapidly enhances novel object recognition among mice. Neuropharmacology. 70: 247-53. PMID 23416700 DOI: 10.1016/J.Neuropharm.2013.01.025 |
0.653 |
|
| 2013 |
Armishaw CJ, Banerjee J, Ganno ML, Reilley KJ, Eans SO, Mizrachi E, Gyanda R, Hoot MR, Houghten RA, McLaughlin JP. Discovery of novel antinociceptive α-conotoxin analogues from the direct in vivo screening of a synthetic mixture-based combinatorial library. Acs Combinatorial Science. 15: 153-61. PMID 23414173 DOI: 10.1021/Co300152X |
0.351 |
|
| 2013 |
Hoot MR, Sypek EI, Reilley KJ, Carey AN, Bidlack JM, McLaughlin JP. Inhibition of Gβγ-subunit signaling potentiates morphine-induced antinociception but not respiratory depression, constipation, locomotion, and reward. Behavioural Pharmacology. 24: 144-52. PMID 23412114 DOI: 10.1097/Fbp.0B013E32835F3D2F |
0.804 |
|
| 2013 |
Aldrich JV, Senadheera SN, Ross NC, Ganno ML, Eans SO, McLaughlin JP. The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine-seeking behavior. Journal of Natural Products. 76: 433-8. PMID 23327691 DOI: 10.1021/Np300697K |
0.715 |
|
| 2013 |
Carey AN, Liu X, Mintzopoulos D, Paris JJ, Muschamp JW, McLaughlin JP, Kaufman MJ. Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 43: 49-54. PMID 23269344 DOI: 10.1016/J.Pnpbp.2012.12.018 |
0.778 |
|
| 2013 |
Jackson KJ, McLaughlin JP, Carroll FI, Damaj MI. Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice. Psychopharmacology. 226: 763-8. PMID 22526543 DOI: 10.1007/S00213-012-2716-Y |
0.456 |
|
| 2012 |
Aldrich JV, McLaughlin JP. Opioid Peptides: Potential for Drug Development. Drug Discovery Today. Technologies. 9: e23-e31. PMID 23316256 DOI: 10.1016/J.Ddtec.2011.07.007 |
0.709 |
|
| 2012 |
Carey AN, Sypek EI, Singh HD, Kaufman MJ, McLaughlin JP. Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse. Behavioural Brain Research. 229: 48-56. PMID 22197678 DOI: 10.1016/J.Bbr.2011.12.019 |
0.701 |
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| 2012 |
Ross NC, Reilley KJ, Murray TF, Aldrich JV, McLaughlin JP. Novel opioid cyclic tetrapeptides: Trp isomers of CJ-15,208 exhibit distinct opioid receptor agonism and short-acting κ opioid receptor antagonism. British Journal of Pharmacology. 165: 1097-108. PMID 21671905 DOI: 10.1111/J.1476-5381.2011.01544.X |
0.733 |
|
| 2011 |
Paris JJ, Reilley KJ, McLaughlin JP. Kappa Opioid Receptor-Mediated Disruption of Novel Object Recognition: Relevance for Psychostimulant Treatment. Journal of Addiction Research & Therapy. PMID 22900234 DOI: 10.4172/2155-6105.S4-007 |
0.723 |
|
| 2011 |
Grimwood S, Lu Y, Schmidt AW, Vanase-Frawley MA, Sawant-Basak A, Miller E, McLean S, Freeman J, Wong S, McLaughlin JP, Verhoest PR. Pharmacological characterization of 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors. The Journal of Pharmacology and Experimental Therapeutics. 339: 555-66. PMID 21821697 DOI: 10.1124/Jpet.111.185108 |
0.435 |
|
| 2011 |
Aldrich JV, Kulkarni SS, Senadheera SN, Ross NC, Reilley KJ, Eans SO, Ganno ML, Murray TF, McLaughlin JP. Unexpected opioid activity profiles of analogues of the novel peptide kappa opioid receptor ligand CJ-15,208. Chemmedchem. 6: 1739-45. PMID 21761566 DOI: 10.1002/Cmdc.201100113 |
0.689 |
|
| 2010 |
Ross NC, Kulkarni SS, McLaughlin JP, Aldrich JV. Synthesis of CJ-15,208, a novel κ-opioid receptor antagonist. Tetrahedron Letters. 51: 5020-5023. PMID 22865937 DOI: 10.1016/J.Tetlet.2010.07.086 |
0.672 |
|
| 2010 |
Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA. Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library. The Aaps Journal. 12: 318-29. PMID 20422341 DOI: 10.1208/S12248-010-9191-3 |
0.409 |
|
| 2010 |
Sperling RE, Gomes SM, Sypek EI, Carey AN, McLaughlin JP. Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration. Psychopharmacology. 210: 199-209. PMID 20401606 DOI: 10.1007/S00213-010-1844-5 |
0.714 |
|
| 2009 |
McLaughlin JP, Gomes S, Seliga A, Goyette SR, Morrison A, Reich CG, Frye CA. Northeast Under/graduate Research Organization for Neuroscience (NEURON): Our Thirteenth Conference for Neuroscience Trainees and Educators. Journal of Undergraduate Neuroscience Education : June : a Publication of Fun, Faculty For Undergraduate Neuroscience. 7: A65-8. PMID 23493230 |
0.367 |
|
| 2009 |
Aldrich JV, Patkar KA, McLaughlin JP. Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action. Proceedings of the National Academy of Sciences of the United States of America. 106: 18396-401. PMID 19841255 DOI: 10.1073/Pnas.0910180106 |
0.713 |
|
| 2009 |
McLaughlin JP, Gomes S, Seliga A, Ramos-Goyette S, Morrison A, Reich CG, Frye CA. Northeast Under/graduate Research Organization for Neuroscience (NEURON): our 13th conference for neuroscience trainees and educators. Cbe Life Sciences Education. 8: 111-3. PMID 19487498 DOI: 10.1187/Cbe.08-08-0050 |
0.391 |
|
| 2009 |
Aldrich JV, McLaughlin JP. Peptide kappa opioid receptor ligands: potential for drug development. The Aaps Journal. 11: 312-22. PMID 19430912 DOI: 10.1208/S12248-009-9105-4 |
0.729 |
|
| 2009 |
Kulkarni SS, Ross NC, McLaughlin JP, Aldrich JV. Synthesis of cyclic tetrapeptide CJ 15,208: a novel kappa opioid receptor antagonist. Advances in Experimental Medicine and Biology. 611: 269-70. PMID 19400188 DOI: 10.1007/978-0-387-73657-0_121 |
0.71 |
|
| 2009 |
Carey AN, Lyons AM, Shay CF, Dunton O, McLaughlin JP. Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4293-300. PMID 19339623 DOI: 10.1523/Jneurosci.6146-08.2009 |
0.716 |
|
| 2008 |
Reindl JD, Rowan K, Carey AN, Peng X, Neumeyer JL, McLaughlin JP. Antidepressant-like effects of the novel kappa opioid antagonist MCL-144B in the forced-swim test. Pharmacology. 81: 229-35. PMID 18176093 DOI: 10.1159/000112867 |
0.725 |
|
| 2007 |
Carey AN, Borozny K, Aldrich JV, McLaughlin JP. Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn. European Journal of Pharmacology. 569: 84-9. PMID 17568579 DOI: 10.1016/J.Ejphar.2007.05.007 |
0.821 |
|
| 2006 |
McLaughlin JP, Land BB, Li S, Pintar JE, Chavkin C. Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 787-94. PMID 16123754 DOI: 10.1038/Sj.Npp.1300860 |
0.775 |
|
| 2006 |
McLaughlin JP, Li S, Valdez J, Chavkin TA, Chavkin C. Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1241-8. PMID 16123746 DOI: 10.1038/Sj.Npp.1300872 |
0.666 |
|
| 2004 |
Xu M, Petraschka M, McLaughlin JP, Westenbroek RE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Terman GW, Chavkin C. Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4576-84. PMID 15140929 DOI: 10.1523/Jneurosci.5552-03.2004 |
0.657 |
|
| 2004 |
McLaughlin JP, Myers LC, Zarek PE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Chavkin C. Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. The Journal of Biological Chemistry. 279: 1810-8. PMID 14597630 DOI: 10.1074/Jbc.M305796200 |
0.644 |
|
| 2004 |
Petraschka M, Xu M, Westenbroek R, McLaughlin J, Chavkin C. Animal models of chronic pain The Journal of Pain. 5: S14. DOI: 10.1016/J.Jpain.2004.02.022 |
0.534 |
|
| 2003 |
McLaughlin JP, Marton-Popovici M, Chavkin C. Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5674-83. PMID 12843270 |
0.628 |
|
| 2003 |
McLaughlin JP, Xu M, Mackie K, Chavkin C. Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. The Journal of Biological Chemistry. 278: 34631-40. PMID 12815037 DOI: 10.1074/Jbc.M304022200 |
0.616 |
|
| 2003 |
McLaughlin JP, Marton-Popovici M, Chavkin C. κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses The Journal of Neuroscience. 23: 5674-5683. DOI: 10.1523/Jneurosci.23-13-05674.2003 |
0.664 |
|
| 2002 |
Bidlack JM, Cohen DJ, McLaughlin JP, Lou R, Ye Y, Wentland MP. 8-Carboxamidocyclazocine: A long-acting, novel benzomorphan Journal of Pharmacology and Experimental Therapeutics. 302: 374-380. PMID 12065740 DOI: 10.1124/Jpet.302.1.374 |
0.682 |
|
| 2001 |
Chavkin C, McLaughlin JP, Celver JP. Regulation of opioid receptor function by chronic agonist exposure: constitutive activity and desensitization. Molecular Pharmacology. 60: 20-5. PMID 11408596 DOI: 10.1124/Mol.60.1.20 |
0.821 |
|
| 2001 |
McLaughlin JP, Chavkin C. Tyrosine phosphorylation of the mu-opioid receptor regulates agonist intrinsic efficacy. Molecular Pharmacology. 59: 1360-8. PMID 11353794 DOI: 10.1124/Mol.59.6.1360 |
0.619 |
|
| 2000 |
Appleyard SM, McLaughlin JP, Chavkin C. Tyrosine phosphorylation of the kappa -opioid receptor regulates agonist efficacy. The Journal of Biological Chemistry. 275: 38281-5. PMID 10995763 DOI: 10.1074/Jbc.M006756200 |
0.769 |
|
| 2000 |
Bidlack JM, McLaughlin JP, Wentland MP. Partial opioids. Medications for the treatment of pain and drug abuse Annals of the New York Academy of Sciences. 909: 1-11. PMID 10911920 DOI: 10.1111/J.1749-6632.2000.Tb06672.X |
0.682 |
|
| 1999 |
Xie W, Samoriski GM, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D. Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids. Proceedings of the National Academy of Sciences of the United States of America. 96: 10385-90. PMID 10468617 DOI: 10.1073/Pnas.96.18.10385 |
0.655 |
|
| 1999 |
McLaughlin JP, Hill KP, Jiang Q, Sebastian A, Archer S, Bidlack JM. Nitrocinnamoyl and chlorocinnamoyl derivatives of dihydrocodeinone: In vivo and in vitro characterization of μ-selective agonist and antagonist activity Journal of Pharmacology and Experimental Therapeutics. 289: 304-311. PMID 10087018 |
0.337 |
|
| 1997 |
McLaughlin JP, Sebastian A, Archer S, Bidlack JM. 14β-Chlorocinnamoylamino derivatives of metopon: Long-term μ-opioid receptor antagonists European Journal of Pharmacology. 320: 121-129. PMID 9059844 DOI: 10.1016/S0014-2999(96)00904-1 |
0.65 |
|
| 1995 |
McLaughlin JP, Nowak D, Sebastian A, Schultz AG, Archer S, Bidlack JM. Metopon and two unique derivatives: affinity and selectivity for the multiple opioid receptors. European Journal of Pharmacology. 294: 201-6. PMID 8788432 DOI: 10.1016/0014-2999(95)00536-6 |
0.625 |
|
| 1994 |
McLaughlin JP, Sebastian A, Archer S, Bidlack JM. 14β-Chlorocinnamoylamino derivatives of metopon interact differentially with the mu opioid receptor Regulatory Peptides. 54: 187-188. DOI: 10.1016/0167-0115(94)90453-7 |
0.636 |
|
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