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Yueming Li - Publications

Affiliations: 
Cornell University, Ithaca, NY, United States 
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62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Meah A, Vedarethinam V, Bronstein R, Gujarati N, Jain T, Mallipattu SK, Li Y, Wang J. Single-Cell Spatial MIST for Versatile, Scalable Detection of Protein Markers. Biosensors. 13. PMID 37754086 DOI: 10.3390/bios13090852  0.644
2023 Jain T, Li YM. Gut microbes modulate neurodegeneration. Science (New York, N.Y.). 379: 142-143. PMID 36634183 DOI: 10.1126/science.adf9548  0.626
2022 Yang L, Ball A, Liu J, Jain T, Li YM, Akhter F, Zhu D, Wang J. Cyclic microchip assay for measurement of hundreds of functional proteins in single neurons. Nature Communications. 13: 3548. PMID 35729174 DOI: 10.1038/s41467-022-31336-x  0.677
2022 Jonas LA, Jain T, Li YM. Functional insight into LOAD-associated microglial response genes. Open Biology. 12: 210280. PMID 35078351 DOI: 10.1098/rsob.210280  0.663
2022 Luo JE, Li YM. Turning the tide on Alzheimer's disease: modulation of γ-secretase. Cell & Bioscience. 12: 2. PMID 34983641 DOI: 10.1186/s13578-021-00738-7  0.336
2020 Mekala S, Nelson G, Li YM. Recent developments of small molecule γ-secretase modulators for Alzheimer's disease. Rsc Medicinal Chemistry. 11: 1003-1022. PMID 33479693 DOI: 10.1039/d0md00196a  0.334
2020 Wong E, Frost GR, Li YM. γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors. Frontiers in Aging Neuroscience. 12: 614690. PMID 33343338 DOI: 10.3389/fnagi.2020.614690  0.333
2020 Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, ... ... Li YM, et al. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. Nature. PMID 32879487 DOI: 10.1038/S41586-020-2681-2  0.422
2020 Luo W, Ip FCF, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng EYL, Wu X, Bustos V, Greengard P, Li YM, Sinha SC, Ip NY. A pentacyclic triterpene from targets γ-secretase. Acs Chemical Neuroscience. PMID 32786303 DOI: 10.1021/Acschemneuro.0C00389  0.427
2019 Zhao J, Xiao Y, Liu X, Kim S, Wu X, Barros M, Zhuang M, Robakis NK, Li Y, Wang C. SUBSTRATE BINDING INHIBITS γ-SECRETASE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN Alzheimers & Dementia. 15: 1595. DOI: 10.1016/J.Jalz.2019.09.052  0.38
2017 Frost GR, Li YM. The role of astrocytes in amyloid production and Alzheimer's disease. Open Biology. 7. PMID 29237809 DOI: 10.1098/rsob.170228  0.301
2017 Johnson DS, Li YM, Pettersson M, St George-Hyslop PH. Structural and Chemical Biology of Presenilin Complexes. Cold Spring Harbor Perspectives in Medicine. PMID 28320827 DOI: 10.1101/Cshperspect.A024067  0.361
2017 Gertsik N, Am Ende CW, Geoghegan KF, Nguyen C, Mukherjee P, Mente S, Seneviratne U, Johnson DS, Li YM. Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes. Cell Chemical Biology. PMID 28065657 DOI: 10.1016/J.Chembiol.2016.12.006  0.36
2016 Crump CJ, Murrey HE, Ballard TE, Am Ende CW, Wu X, Gertsik N, Johnson DS, Li YM. Development of Sulfonamide Photoaffinity Inhibitors for Probing Cellular γ-Secretase. Acs Chemical Neuroscience. PMID 27253220 DOI: 10.1021/Acschemneuro.6B00127  0.373
2016 Carroll CM, Li YM. Physiological and pathological roles of the γ-secretase complex. Brain Research Bulletin. PMID 27133790 DOI: 10.1016/j.brainresbull.2016.04.019  0.352
2016 Zhang X, Sullivan E, Scimeca M, Wu X, Li YM, Sisodia SS. Evidence that the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity. The Journal of Biological Chemistry. PMID 26887941 DOI: 10.1074/Jbc.C115.701649  0.353
2015 Gilchrist ML, Ahn K, Li YM. Imaging and Functional Analysis of γ-Secretase and Substrate in a Proteolipobead System with an Activity-Based Probe. Analytical Chemistry. PMID 26699370 DOI: 10.1021/Acs.Analchem.5B03762  0.309
2015 Dang S, Wu S, Wang J, Li H, Huang M, He W, Li YM, Wong CC, Shi Y. Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH. Proceedings of the National Academy of Sciences of the United States of America. 112: 3344-9. PMID 25733893 DOI: 10.1073/Pnas.1502150112  0.362
2014 Gertsik N, Chiu D, Li YM. Complex regulation of γ-secretase: from obligatory to modulatory subunits. Frontiers in Aging Neuroscience. 6: 342. PMID 25610395 DOI: 10.3389/Fnagi.2014.00342  0.44
2014 Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner SL, Wang R, Koide S, Sisodia SS. A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase. The Journal of Biological Chemistry. 289: 34851-61. PMID 25352592 DOI: 10.1074/Jbc.M114.609636  0.434
2014 Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, Hu CJ, de Stanchina E, Simon MC, Sisodia SS, Scheinberg DA, Li YM. Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer. Cell Reports. 8: 1077-92. PMID 25131208 DOI: 10.1016/J.Celrep.2014.07.028  0.348
2014 Gertsik N, Ballard TE, Am Ende CW, Johnson DS, Li YM. Development of CBAP-BPyne, a probe for γ-secretase and presenilinase. Medchemcomm. 5: 338-341. PMID 24914408 DOI: 10.1039/C3Md00281K  0.379
2014 Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 53: 702-13. PMID 24401146 DOI: 10.1021/Bi401537V  0.39
2013 Crump CJ, Johnson DS, Li YM. Development and mechanism of γ-secretase modulators for Alzheimer's disease. Biochemistry. 52: 3197-216. PMID 23614767 DOI: 10.1021/Bi400377P  0.455
2013 Chau DM, Shum D, Radu C, Bhinder B, Gin D, Gilchrist ML, Djaballah H, Li YM. A novel high throughput 1536-well notch1 γsecretase AlphaLISA assay Combinatorial Chemistry and High Throughput Screening. 16: 415-424. PMID 23448293 DOI: 10.2174/1386207311316060001  0.351
2013 Pozdnyakov N, Murrey HE, Crump CJ, Pettersson M, Ballard TE, Am Ende CW, Ahn K, Li YM, Bales KR, Johnson DS. γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin. The Journal of Biological Chemistry. 288: 9710-20. PMID 23396974 DOI: 10.1074/Jbc.M112.398602  0.396
2013 Li Y. Endogenous and exogenous regulation of gamma-secretase Molecular Neurodegeneration. 8: 1-1. DOI: 10.1186/1750-1326-8-S1-O10  0.387
2012 Crump CJ, Castro SV, Wang F, Pozdnyakov N, Ballard TE, Sisodia SS, Bales KR, Johnson DS, Li YM. BMS-708,163 targets presenilin and lacks notch-sparing activity. Biochemistry. 51: 7209-11. PMID 22931393 DOI: 10.1021/Bi301137H  0.349
2012 Zhang X, Hoey RJ, Lin G, Koide A, Leung B, Ahn K, Dolios G, Paduch M, Ikeuchi T, Wang R, Li YM, Koide S, Sisodia SS. Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies. Proceedings of the National Academy of Sciences of the United States of America. 109: 8534-9. PMID 22586122 DOI: 10.1073/Pnas.1202691109  0.349
2012 Chau DM, Crump CJ, Villa JC, Scheinberg DA, Li YM. Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase. The Journal of Biological Chemistry. 287: 17288-96. PMID 22461631 DOI: 10.1074/Jbc.M111.300483  0.363
2012 Crump CJ, am Ende CW, Ballard TE, Pozdnyakov N, Pettersson M, Chau DM, Bales KR, Li YM, Johnson DS. Development of clickable active site-directed photoaffinity probes for γ-secretase. Bioorganic & Medicinal Chemistry Letters. 22: 2997-3000. PMID 22418280 DOI: 10.1016/J.Bmcl.2012.02.027  0.341
2012 Li Y. Gamma-secretase: from pathogenesis to therapeutics. Molecular Neurodegeneration. 7: 1-1. DOI: 10.1186/1750-1326-7-S1-L4  0.369
2011 Crump CJ, Fish BA, Castro SV, Chau DM, Gertsik N, Ahn K, Stiff C, Pozdnyakov N, Bales KR, Johnson DS, Li YM. Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1. Acs Chemical Neuroscience. 2: 705-710. PMID 22229075 DOI: 10.1021/Cn200098P  0.433
2011 Crump CJ, Johnson DS, Li YM. Target of γ-secretase modulators, presenilin marks the spot. The Embo Journal. 30: 4696-8. PMID 22126818 DOI: 10.1038/Emboj.2011.410  0.422
2011 Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, et al. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. Cell. 147: 615-28. PMID 22036569 DOI: 10.1016/J.Cell.2011.09.036  0.315
2011 Renzi F, Zhang X, Rice WJ, Torres-Arancivia C, Gomez-Llorente Y, Diaz R, Ahn K, Yu C, Li YM, Sisodia SS, Ubarretxena-Belandia I. Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy. The Journal of Biological Chemistry. 286: 21440-9. PMID 21454611 DOI: 10.1074/Jbc.M110.193326  0.365
2010 Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM. Activation and intrinsic gamma-secretase activity of presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. 107: 21435-40. PMID 21115843 DOI: 10.1073/Pnas.1013246107  0.377
2010 Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, ... ... Li YM, et al. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 67: 769-80. PMID 20826309 DOI: 10.1016/J.Neuron.2010.08.018  0.424
2010 Tian Y, Crump CJ, Li YM. Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production. The Journal of Biological Chemistry. 285: 32549-56. PMID 20675367 DOI: 10.1074/Jbc.M110.128439  0.397
2010 Placanica L, Chien JW, Li YM. Characterization of an atypical gamma-secretase complex from hematopoietic origin. Biochemistry. 49: 2796-804. PMID 20178366 DOI: 10.1021/Bi901388T  0.395
2010 Tian Y, Bassit B, Chau D, Li YM. An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production. Nature Structural & Molecular Biology. 17: 151-8. PMID 20062056 DOI: 10.1038/nsmb.1743  0.314
2009 Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM. Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 106: 20228-33. PMID 19906985 DOI: 10.1073/Pnas.0910757106  0.308
2009 Shelton CC, Tian Y, Shum D, Radu C, Djaballah H, Li YM. A miniaturized 1536-well format gamma-secretase assay. Assay and Drug Development Technologies. 7: 461-70. PMID 19715456 DOI: 10.1089/Adt.2009.0202  0.411
2009 Escobar-Alvarez S, Goldgur Y, Yang G, Ouerfelli O, Li Y, Scheinberg DA. Structure and activity of human mitochondrial peptide deformylase, a novel cancer target. Journal of Molecular Biology. 387: 1211-28. PMID 19236878 DOI: 10.1016/J.Jmb.2009.02.032  0.317
2009 Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. The Journal of Biological Chemistry. 284: 2967-77. PMID 19036728 DOI: 10.1074/Jbc.M807269200  0.388
2008 Lei X, Ahn K, Zhu L, Ubarretxena-Belandia I, Li YM. Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents. Biochemistry. 47: 11920-9. PMID 18937501 DOI: 10.1021/Bi800385R  0.342
2008 Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Parent AT, Saido TC, Li YM, Sisodia SS, et al. Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. The Journal of Biological Chemistry. 283: 19489-98. PMID 18456655 DOI: 10.1074/Jbc.M801037200  0.347
2007 Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM. {gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE. The Journal of Biological Chemistry. 282: 23639-44. PMID 17556361 DOI: 10.1074/Jbc.M704601200  0.382
2007 Antczak C, Shum D, Escobar S, Bassit B, Kim E, Seshan VE, Wu N, Yang G, Ouerfelli O, Li YM, Scheinberg DA, Djaballah H. High-throughput identification of inhibitors of human mitochondrial peptide deformylase. Journal of Biomolecular Screening. 12: 521-35. PMID 17435169 DOI: 10.1177/1087057107300463  0.302
2007 Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas MZ, Thinakaran G. Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Molecular Neurodegeneration. 2: 4. PMID 17288597 DOI: 10.1186/1750-1326-2-4  0.415
2006 Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li YM, Zheng H. Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3845-54. PMID 16597739 DOI: 10.1523/Jneurosci.5384-05.2006  0.434
2006 Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage. Journal of Neurochemistry. 96: 118-25. PMID 16300640 DOI: 10.1111/J.1471-4159.2005.03528.X  0.319
2004 Carter TL, Verdile G, Groth D, Bogush A, Thomas S, Shen P, Fraser PE, Mathews P, Nixon RA, Ehrlich ME, Kwok JB, St George-Hyslop P, Schofield P, Li Y, Yang A, et al. Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer Disease and Associated Disorders. 18: 261-3. PMID 15592142  0.33
2004 Tarassishin L, Yin YI, Bassit B, Li YM. Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct. Proceedings of the National Academy of Sciences of the United States of America. 101: 17050-5. PMID 15563588 DOI: 10.1073/Pnas.0408007101  0.414
2004 Kim SH, Yin YI, Li YM, Sisodia SS. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. The Journal of Biological Chemistry. 279: 48615-9. PMID 15456788 DOI: 10.1074/Jbc.C400396200  0.39
2004 Wang H, Luo WJ, Zhang YW, Li YM, Thinakaran G, Greengard P, Xu H. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components. The Journal of Biological Chemistry. 279: 40560-6. PMID 15247291 DOI: 10.1074/Jbc.M404345200  0.389
2003 Lee MD, Antczak C, Li Y, Sirotnak FM, Bornmann WG, Scheinberg DA. A new human peptide deformylase inhibitable by actinonin. Biochemical and Biophysical Research Communications. 312: 309-15. PMID 14637138 DOI: 10.1016/J.Bbrc.2003.10.123  0.31
2003 Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/Pnas.1735338100  0.409
2003 Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P. Gleevec inhibits beta-amyloid production but not Notch cleavage. Proceedings of the National Academy of Sciences of the United States of America. 100: 12444-9. PMID 14523244 DOI: 10.1073/Pnas.1534745100  0.401
2002 Xu M, Lai MT, Huang Q, DiMuzio-Mower J, Castro JL, Harrison T, Nadin A, Neduvelil JG, Shearman MS, Shafer JA, Gardell SJ, Li YM. gamma-Secretase: characterization and implication for Alzheimer disease therapy. Neurobiology of Aging. 23: 1023-30. PMID 12470798  0.348
2002 Figueroa DJ, Morris JA, Ma L, Kandpal G, Chen E, Li YM, Austin CP. Presenilin-dependent gamma-secretase activity modulates neurite outgrowth. Neurobiology of Disease. 9: 49-60. PMID 11848684 DOI: 10.1006/nbdi.2001.0447  0.33
2000 Beher D, Li Y, Gardell SJ, Shearman MS. Direct analysis of γ-secretase activity in SH-SY5Y neuroblastoma cells identifies the Golgi as the main compartment of amyloid-β(X-40) peptide. Generation Neurobiology of Aging. 21: 187. DOI: 10.1016/S0197-4580(00)82183-1  0.338
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