Un J. Kang, Md - Publications

Affiliations: 
Columbia University, New York, NY 
Area:
Molecular Mechanisms of Neurodegeneration, Models of Parkinson's Disease, Basal Ganglia Circuitry and Plasticity

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Year Citation  Score
2020 Choi SJ, Ma TC, Ding Y, Cheung T, Joshi N, Sulzer D, Mosharov EV, Kang UJ. Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA. Elife. 9. PMID 32687053 DOI: 10.7554/Elife.56920  0.373
2020 Papa SM, Brundin P, Fung VSC, Kang UJ, Burn DJ, Colosimo C, Chiang HL, Alcalay RN, Trenkwalder C. Impact of the COVID-19 Pandemic on Parkinson's Disease and Movement Disorders. Movement Disorders Clinical Practice. 7: 357-360. PMID 32373651 DOI: 10.1002/Mdc3.12953  0.332
2020 Papa SM, Brundin P, Fung VSC, Kang UJ, Burn DJ, Colosimo C, Chiang HL, Alcalay RN, Trenkwalde C. Impact of the COVID-19 pandemic on Parkinson's disease and movement disorders. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32250460 DOI: 10.1002/Mds.28067  0.332
2020 Choi SJ, Ma TC, Ding Y, Cheung T, Joshi N, Sulzer D, Mosharov EV, Kang UJ. Author response: Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA Elife. DOI: 10.7554/Elife.56920.Sa2  0.344
2019 Hu Y, Zhang K, Zhang T, Wang J, Chen F, Qin W, Tong W, Guan Q, He Y, Gu C, Chen X, Kang UJ, Sun YE, Li S, Jin L. Exercise Reverses Dysregulation of T-Cell-Related Function in Blood Leukocytes of Patients With Parkinson's Disease. Frontiers in Neurology. 10: 1389. PMID 32047471 DOI: 10.3389/Fneur.2019.01389  0.33
2019 Luo L, Andrews H, Alcalay RN, Poyraz FC, Boehme AK, Goldman JG, Xie T, Tuite P, Henchcliffe C, Hogarth P, Amara AW, Frank S, Sutherland M, Kopil C, Naito A, ... Kang UJ, et al. Motor phenotype classification in moderate to advanced PD in BioFIND study. Parkinsonism & Related Disorders. PMID 31255537 DOI: 10.1016/J.Parkreldis.2019.06.017  0.332
2019 Kang UJ, Boehme AK, Fairfoul G, Shahnawaz M, Ma TC, Hutten SJ, Green A, Soto C. Comparative study of cerebrospinal fluid α-synuclein seeding aggregation assays for diagnosis of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30840785 DOI: 10.1002/Mds.27646  0.323
2019 Alcalay RN, Mallett V, Vanderperre B, Tavassoly O, Dauvilliers Y, Wu RYJ, Ruskey JA, Leblond CS, Ambalavanan A, Laurent SB, Spiegelman D, Dionne-Laporte A, Liong C, Levy OA, Fahn S, ... ... Kang UJ, et al. SMPD1 mutations, activity, and α-synuclein accumulation in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30788890 DOI: 10.1002/Mds.27642  0.361
2018 Meszaros J, Cheung T, Erler MM, Kang UJ, Sames D, Kellendonk C, Sulzer D. Evoked transients of pH-sensitive fluorescent false neurotransmitter reveal dopamine hot spots in the globus pallidus. Elife. 7. PMID 30566076 DOI: 10.7554/Elife.42383  0.608
2018 Chuhma N, Mingote S, Yetnikoff L, Kalmbach A, Ma T, Ztaou S, Sienna AC, Tepler S, Poulin JF, Ansorge M, Awatramani R, Kang UJ, Rayport S. Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons. Elife. 7. PMID 30295607 DOI: 10.7554/Elife.39786  0.359
2018 Li H, Ham A, Ma TC, Kuo SH, Kanter E, Kim D, Ko HS, Quan Y, Sardi SP, Li A, Arancio O, Kang UJ, Sulzer D, Tang G. Mitochondrial Dysfunction and Mitophagy Defect Triggered by Heterozygous GBA Mutations. Autophagy. PMID 30160596 DOI: 10.1080/15548627.2018.1509818  0.301
2018 Xie T, Bloom L, Padmanaban M, Bertacchi B, Kang W, MacCracken E, Dachman A, Vigil J, Satzer D, Zadikoff C, Markopoulou K, Warnke P, Kang UJ. Long-term effect of low frequency stimulation of STN on dysphagia, freezing of gait and other motor symptoms in PD. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 29654112 DOI: 10.1136/Jnnp-2018-318060  0.348
2018 Sulzer D, Cassidy C, Horga G, Kang UJ, Fahn S, Casella L, Pezzoli G, Langley J, Hu XP, Zucca FA, Isaias IU, Zecca L. Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson's disease. Npj Parkinson's Disease. 4: 11. PMID 29644335 DOI: 10.1038/S41531-018-0047-3  0.388
2018 Kim R, Lee J, Kim Y, Kim A, Jang M, Kim HJ, Jeon B, Kang UJ, Fahn S. Presynaptic striatal dopaminergic depletion predicts the later development of freezing of gait in de novo Parkinson's disease: An analysis of the PPMI cohort. Parkinsonism & Related Disorders. PMID 29523394 DOI: 10.1016/J.Parkreldis.2018.02.047  0.426
2018 Alcalay RN, Wolf P, Levy OA, Kang UJ, Waters C, Fahn S, Ford B, Kuo SH, Vanegas N, Shah H, Liong C, Narayan S, Pauciulo MW, Nichols WC, Gan-Or Z, et al. Alpha galactosidase A activity in Parkinson's disease. Neurobiology of Disease. PMID 29369793 DOI: 10.1016/J.Nbd.2018.01.012  0.333
2018 Meszaros J, Cheung T, Erler MM, Kang UJ, Sames D, Kellendonk C, Sulzer D. Author response: Evoked transients of pH-sensitive fluorescent false neurotransmitter reveal dopamine hot spots in the globus pallidus Elife. DOI: 10.7554/Elife.42383.020  0.59
2018 Chuhma N, Mingote S, Yetnikoff L, Kalmbach A, Ma T, Ztaou S, Sienna A, Tepler S, Poulin J, Ansorge M, Awatramani R, Kang UJ, Rayport S. Author response: Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons Elife. DOI: 10.7554/Elife.39786.027  0.354
2018 Cassidy C, Girgis R, Zecca L, Zucca F, Bellei C, Baker S, Weinstein J, Martinez CB, Kang U, Snellenberg JV, Sulzer D, Abi-Dargham A, Horga G. S236. Neuromelanin-Sensitive MRI: A Novel, Non-Invasive Proxy Measure of Dopamine Function in Neuropsychiatric Illness Biological Psychiatry. 83. DOI: 10.1016/J.Biopsych.2018.02.1128  0.32
2017 Martelli D, Luo L, Kang J, Kang UJ, Fahn S, Agrawal SK. Adaptation of Stability during Perturbed Walking in Parkinson's Disease. Scientific Reports. 7: 17875. PMID 29259237 DOI: 10.1038/S41598-017-18075-6  0.35
2017 Goldman JG, Andrews H, Amara A, Naito A, Alcalay RN, Shaw LM, Taylor P, Xie T, Tuite P, Henchcliffe C, Hogarth P, Frank S, Saint-Hilaire MH, Frasier M, Arnedo V, ... ... Kang UJ, et al. Cerebrospinal fluid, plasma, and saliva in the BioFIND study: Relationships among biomarkers and Parkinson's disease Features. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 29205509 DOI: 10.1002/Mds.27232  0.355
2017 Sklerov M, Kang UJ, Liong C, Clark L, Marder K, Pauciulo M, Nichols WC, Chung WK, Honig LS, Cortes E, Vonsattel JP, Alcalay RN. Frequency of GBA variants in autopsy-proven multiple system atrophy. Movement Disorders Clinical Practice. 4: 574-581. PMID 28966932 DOI: 10.1002/Mdc3.12481  0.302
2017 Chan RB, Perotte AJ, Zhou B, Liong C, Shorr EJ, Marder KS, Kang UJ, Waters CH, Levy OA, Xu Y, Shim HB, Pe'er I, Di Paolo G, Alcalay RN. Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis. Plos One. 12: e0172348. PMID 28212433 DOI: 10.1371/Journal.Pone.0172348  0.336
2016 Xie T, Kang UJ. Comments on the recent viewpoint article on low-frequency deep brain stimulation for Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 27862290 DOI: 10.1002/Mds.26861  0.318
2016 Barca E, Kleiner G, Tang G, Ziosi M, Tadesse S, Masliah E, Louis ED, Faust P, Kang UJ, Torres J, Cortes EP, Vonsattel JG, Kuo SH, Quinzii CM. Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum. Journal of Neuropathology and Experimental Neurology. PMID 27235405 DOI: 10.1093/Jnen/Nlw037  0.334
2016 Kang UJ, Goldman JG, Alcalay RN, Xie T, Tuite P, Henchcliffe C, Hogarth P, Amara AW, Frank S, Rudolph A, Casaceli C, Andrews H, Gwinn K, Sutherland M, Kopil C, et al. The BioFIND study: Characteristics of a clinically typical Parkinson's disease biomarker cohort. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 27113479 DOI: 10.1002/Mds.26613  0.365
2016 Alcalay RN, Levy OA, Wolf P, Oliva P, Zhang XK, Waters CH, Fahn S, Kang U, Liong C, Ford B, Mazzoni P, Kuo S, Johnson A, Xiong L, Rouleau GA, et al. SCARB2 variants and glucocerebrosidase activity in Parkinson's disease. Npj Parkinson's Disease. 2. PMID 27110593 DOI: 10.1038/Npjparkd.2016.4  0.307
2015 Jankovic J, Bressman S, Dauer W, Kang UJ. Clinical and scientific perspectives on movement disorders: Stanley Fahn's contributions. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 1862-9. PMID 26477883 DOI: 10.1002/Mds.26445  0.304
2015 Bastide MF, Meissner WG, Picconi B, Fasano S, Fernagut PO, Feyder M, Francardo V, Alcacer C, Ding Y, Brambilla R, Fisone G, Jon Stoessl A, Bourdenx M, Engeln M, Navailles S, ... ... Kang UJ, et al. Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease. Progress in Neurobiology. PMID 26209473 DOI: 10.1016/J.Pneurobio.2015.07.002  0.354
2015 Cazorla M, Kang UJ, Kellendonk C. Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 895-903. PMID 26018615 DOI: 10.1002/Mds.26282  0.64
2015 Lim SA, Xia R, Ding Y, Won L, Ray WJ, Hitchcock SA, McGehee DS, Kang UJ. Enhanced histamine H2 excitation of striatal cholinergic interneurons in L-DOPA-induced dyskinesia. Neurobiology of Disease. 76: 67-76. PMID 25661301 DOI: 10.1016/J.Nbd.2015.01.003  0.379
2015 Stewart T, Sossi V, Aasly JO, Wszolek ZK, Uitti RJ, Hasegawa K, Yokoyama T, Zabetian CP, Leverenz JB, Stoessl AJ, Wang Y, Ginghina C, Liu C, Cain KC, Auinger P, ... Kang UJ, et al. Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity. Acta Neuropathologica Communications. 3: 7. PMID 25637461 DOI: 10.1186/S40478-015-0185-3  0.365
2015 Xie T, Vigil J, MacCracken E, Gasparaitis A, Young J, Kang W, Bernard J, Warnke P, Kang UJ. Low-frequency stimulation of STN-DBS reduces aspiration and freezing of gait in patients with PD. Neurology. 84: 415-20. PMID 25540305 DOI: 10.1212/Wnl.0000000000001184  0.342
2015 Cazorla M, Kang UJ, Kellendonk C. Balancing the basal ganglia circuitry: A possible new role for dopamine D2 receptors in health and disease Movement Disorders. 30: 895-903. DOI: 10.1002/mds.26282  0.579
2014 Lim SA, Kang UJ, McGehee DS. Striatal cholinergic interneuron regulation and circuit effects. Frontiers in Synaptic Neuroscience. 6: 22. PMID 25374536 DOI: 10.3389/Fnsyn.2014.00022  0.356
2014 Beal MF, Oakes D, Shoulson I, Henchcliffe C, Galpern WR, Haas R, Juncos JL, Nutt JG, Voss TS, Ravina B, Shults CM, Helles K, Snively V, Lew MF, ... ... Kang UJ, et al. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. Jama Neurology. 71: 543-52. PMID 24664227 DOI: 10.1001/Jamaneurol.2014.131  0.339
2014 Won L, Ding Y, Singh P, Kang UJ. Striatal cholinergic cell ablation attenuates L-DOPA induced dyskinesia in parkinsonian mice Journal of Neuroscience. 34: 3090-3094. PMID 24553948 DOI: 10.1523/Jneurosci.2888-13.2014  0.376
2014 Lin W, Wadlington NL, Chen L, Zhuang X, Brorson JR, Kang UJ. Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3079-89. PMID 24553947 DOI: 10.1523/Jneurosci.2286-13.2014  0.348
2014 Frasier M, Kang UJ. Parkinson's disease biomarkers: Resources for discovery and validation Neuropsychopharmacology. 39: 241-242. PMID 24317317 DOI: 10.1038/Npp.2013.246  0.378
2013 Zhang J, Mattison HA, Liu C, Ginghina C, Auinger P, McDermott MP, Stewart T, Kang UJ, Cain KC, Shi M. Longitudinal assessment of tau and amyloid beta in cerebrospinal fluid of Parkinson disease. Acta Neuropathologica. 126: 671-82. PMID 23644819 DOI: 10.1007/S00401-013-1121-X  0.345
2013 Zhuang X, Mazzoni P, Kang UJ. The role of neuroplasticity in dopaminergic therapy for Parkinson disease. Nature Reviews. Neurology. 9: 248-56. PMID 23588357 DOI: 10.1038/Nrneurol.2013.57  0.447
2012 Khoo SK, Petillo D, Kang UJ, Resau JH, Berryhill B, Linder J, Forsgren L, Neuman LA, Tan AC. Plasma-based circulating MicroRNA biomarkers for Parkinson's disease. Journal of Parkinson's Disease. 2: 321-31. PMID 23938262 DOI: 10.3233/Jpd-012144  0.368
2012 Kang UJ, Xie T. Diagnostic biomarkers of Parkinson's disease: what gain at what cost? Journal of Neurology, Neurosurgery, and Psychiatry. 83: 769. PMID 22733084 DOI: 10.1136/Jnnp-2012-302529  0.343
2012 Xie T, Kang UJ, Warnke P. Effect of stimulation frequency on immediate freezing of gait in newly activated STN DBS in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 83: 1015-7. PMID 22696586 DOI: 10.1136/Jnnp-2011-302091  0.311
2012 Kang UJ, Auinger P. Activity enhances dopaminergic long-duration response in Parkinson disease Neurology. 78: 1146-1149. PMID 22459675 DOI: 10.1212/Wnl.0B013E31824F8056  0.405
2011 Shim JH, Yoon SH, Kim KH, Han JY, Ha JY, Hyun DH, Paek SH, Kang UJ, Zhuang X, Son JH. The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells. Mitochondrion. 11: 707-15. PMID 21664494 DOI: 10.1016/J.Mito.2011.05.013  0.404
2011 Shi M, Bradner J, Hancock AM, Chung KA, Quinn JF, Peskind ER, Galasko D, Jankovic J, Zabetian CP, Kim HM, Leverenz JB, Montine TJ, Ginghina C, Kang UJ, Cain KC, et al. Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Annals of Neurology. 69: 570-80. PMID 21400565 DOI: 10.1002/Ana.22311  0.377
2011 Ding Y, Won L, Britt JP, Lim SA, McGehee DS, Kang UJ. Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in parkinsonian mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 840-5. PMID 21187382 DOI: 10.1073/Pnas.1006511108  0.419
2010 Beeler JA, Cao ZF, Kheirbek MA, Ding Y, Koranda J, Murakami M, Kang UJ, Zhuang X. Dopamine-dependent motor learning: insight into levodopa's long-duration response. Annals of Neurology. 67: 639-47. PMID 20437561 DOI: 10.1002/Ana.21947  0.307
2010 Hong Z, Shi M, Chung KA, Quinn JF, Peskind ER, Galasko D, Jankovic J, Zabetian CP, Leverenz JB, Baird G, Montine TJ, Hancock AM, Hwang H, Pan C, Bradner J, ... Kang UJ, et al. DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Brain : a Journal of Neurology. 133: 713-26. PMID 20157014 DOI: 10.1093/Brain/Awq008  0.316
2009 Rotstein M, Kang UJ. Consideration of gene therapy for paediatric neurotransmitter diseases. Journal of Inherited Metabolic Disease. 32: 387-94. PMID 19259783 DOI: 10.1007/S10545-009-1054-7  0.358
2008 Chen L, Ding Y, Cagniard B, Van Laar AD, Mortimer A, Chi W, Hastings TG, Kang UJ, Zhuang X. Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 425-33. PMID 18184785 DOI: 10.1523/Jneurosci.3602-07.2008  0.461
2008 Hong S, Kang UJ, Isacson O, Kim KS. Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons. Journal of Neurochemistry. 104: 316-24. PMID 17944878 DOI: 10.1111/J.1471-4159.2007.04952.X  0.304
2007 Potashkin JA, Kang UJ, Loomis PA, Jodelka FM, Ding Y, Meredith GE. MPTP administration in mice changes the ratio of splice isoforms of fosB and rgs9. Brain Research. 1182: 1-10. PMID 17936734 DOI: 10.1016/J.Brainres.2007.08.080  0.365
2007 Yang W, Chen L, Ding Y, Zhuang X, Kang UJ. Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice. Human Molecular Genetics. 16: 2900-10. PMID 17823202 DOI: 10.1093/Hmg/Ddm249  0.348
2007 Ding Y, Restrepo J, Won L, Hwang DY, Kim KS, Kang UJ. Chronic 3,4-dihydroxyphenylalanine treatment induces dyskinesia in aphakia mice, a novel genetic model of Parkinson's disease. Neurobiology of Disease. 27: 11-23. PMID 17499513 DOI: 10.1016/J.Nbd.2007.03.013  0.418
2006 Meredith GE, Kang UJ. Behavioral models of Parkinson's disease in rodents: a new look at an old problem. Movement Disorders : Official Journal of the Movement Disorder Society. 21: 1595-606. PMID 16830310 DOI: 10.1002/Mds.21010  0.393
2006 Chung S, Shin BS, Hedlund E, Pruszak J, Ferree A, Kang UJ, Isacson O, Kim KS. Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation. Journal of Neurochemistry. 97: 1467-80. PMID 16696855 DOI: 10.1111/J.1471-4159.2006.03841.X  0.306
2006 Kim DW, Chung S, Hwang M, Ferree A, Tsai HC, Park JJ, Chung S, Nam TS, Kang UJ, Isacson O, Kim KS. Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells. Stem Cells (Dayton, Ohio). 24: 557-67. PMID 16123386 DOI: 10.1634/Stemcells.2005-0233  0.363
2005 Lin W, Kang UJ. Neuroprotective therapy in Parkinson's disease: current status and new directions from experimental and genetic clues. Journal of Clinical Neurology (Seoul, Korea). 1: 107-20. PMID 20396458 DOI: 10.3988/Jcn.2005.1.2.107  0.375
2005 Chen L, Cagniard B, Mathews T, Jones S, Koh HC, Ding Y, Carvey PM, Ling Z, Kang UJ, Zhuang X. Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. The Journal of Biological Chemistry. 280: 21418-26. PMID 15799973 DOI: 10.1074/Jbc.M413955200  0.396
2005 Chung S, Hedlund E, Hwang M, Kim DW, Shin BS, Hwang DY, Kang UJ, Isacson O, Kim KS. The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons. Molecular and Cellular Neurosciences. 28: 241-52. PMID 15691706 DOI: 10.1016/J.Mcn.2004.09.008  0.369
2004 Kweon GR, Marks JD, Krencik R, Leung EH, Schumacker PT, Hyland K, Kang UJ. Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells. The Journal of Biological Chemistry. 279: 51783-92. PMID 15469939 DOI: 10.1074/Jbc.M407336200  0.679
2004 Lee EA, Lee WY, Kim YS, Kang UJ. The effects of chronic L-DOPA therapy on pharmacodynamic parameters in a rat model of motor response fluctuations. Experimental Neurology. 184: 304-12. PMID 14637101 DOI: 10.1016/S0014-4886(03)00159-6  0.365
2003 Kang UJ, Nakamura K. Potential of gene therapy for pediatric neurotransmitter diseases: lessons from Parkinson's disease. Annals of Neurology. 54: S103-9. PMID 12891660 DOI: 10.1002/Ana.10654  0.312
2003 Hwang DY, Ardayfio P, Kang UJ, Semina EV, Kim KS. Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice. Brain Research. Molecular Brain Research. 114: 123-31. PMID 12829322 DOI: 10.1016/S0169-328X(03)00162-1  0.353
2002 Siderowf A, Stern M, Shoulson I, Kieburtz K, Oakes D, Day D, Shinaman A, Plumb S, Fahn S, Blindauer K, Lew M, Hurtig H, Lloyd M, Hauser R, Gauger L, ... ... Kang UJ, et al. A controlled trial of rasagiline in early Parkinson disease: The tempo study Archives of Neurology. 59: 1937-1943. PMID 12470183 DOI: 10.1001/Archneur.59.12.1937  0.355
2002 Chung S, Sonntag KC, Andersson T, Bjorklund LM, Park JJ, Kim DW, Kang UJ, Isacson O, Kim KS. Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. The European Journal of Neuroscience. 16: 1829-38. PMID 12453046 DOI: 10.1046/J.1460-9568.2002.02255.X  0.352
2002 Chang JW, Lee WY, Milstien S, Kang UJ. A site-specific mutation of tyrosine hydroxylase reduces feedback inhibition by dopamine in genetically modified cells grafted in parkinsonian rats. Journal of Neurochemistry. 83: 141-9. PMID 12358737 DOI: 10.1046/J.1471-4159.2002.01120.X  0.373
2001 Nakamura K, Bindokas VP, Kowlessur D, Elas M, Milstien S, Marks JD, Halpern HJ, Kang UJ. Tetrahydrobiopterin Scavenges Superoxide in Dopaminergic Neurons Journal of Biological Chemistry. 276: 34402-34407. PMID 11447224 DOI: 10.1074/Jbc.M103766200  0.369
2000 Nakamura K, Ahmed M, Barr E, Leiden JM, Kang UJ. The localization and functional contribution of striatal aromatic L-amino acid decarboxylase to L-3,4-dihydroxyphenylalanine decarboxylation in rodent parkinsonian models. Cell Transplantation. 9: 567-76. PMID 11144954 DOI: 10.1177/096368970000900502  0.409
2000 Nakamura K, Won L, Heller A, Kang UJ. Preferential resistance of dopaminergic neurons to glutathione depletion in a reconstituted nigrostriatal system. Brain Research. 873: 203-11. PMID 10930545 DOI: 10.1016/S0006-8993(00)02425-2  0.373
2000 Nakamura K, Bindokas VP, Marks JD, Wright DA, Frim DM, Miller RJ, Kang UJ. The selective toxicity of 1-methyl-4-phenylpyridinium to dopaminergic neurons: the role of mitochondrial complex I and reactive oxygen species revisited. Molecular Pharmacology. 58: 271-8. PMID 10908294 DOI: 10.1124/Mol.58.2.271  0.372
2000 Nakamura K, Wright DA, Wiatr T, Kowlessur D, Milstien S, Lei XG, Kang UJ. Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin. Journal of Neurochemistry. 74: 2305-14. PMID 10820190 DOI: 10.1046/J.1471-4159.2000.0742305.X  0.364
1999 Frim DM, Kang UJ. Gene therapy for Parkinson's disease: review and update. Expert Opinion On Investigational Drugs. 8: 1551-1564. PMID 11139810 DOI: 10.1517/13543784.8.10.1551  0.362
1999 Chang JW, Wachtel SR, Young D, Kang UJ. Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesions. Neuroscience. 88: 617-28. PMID 10197780 DOI: 10.1016/S0306-4522(98)00217-6  0.342
1999 Lee WY, Chang JW, Nemeth NL, Kang UJ. Vesicular Monoamine Transporter-2 and Aromaticl-Amino Acid Decarboxylase Enhance Dopamine Delivery afterl-3,4-Dihydroxyphenylalanine Administration in Parkinsonian Rats The Journal of Neuroscience. 19: 3266-3274. DOI: 10.1523/Jneurosci.19-08-03266.1999  0.416
1997 Wachtel SR, Bencsics C, Kang UJ. Role of aromatic L-amino acid decarboxylase for dopamine replacement by genetically modified fibroblasts in a rat model of Parkinson's disease. Journal of Neurochemistry. 69: 2055-63. PMID 9349551 DOI: 10.1046/J.1471-4159.1997.69052055.X  0.341
1997 Nakamura K, Wang W, Kang UJ. The role of glutathione in dopaminergic neuronal survival. Journal of Neurochemistry. 69: 1850-8. PMID 9349527 DOI: 10.1046/J.1471-4159.1997.69051850.X  0.382
1996 Bencsics C, Wachtel SR, Milstien S, Hatakeyama K, Becker JB, Kang UJ. Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 4449-56. PMID 8699255 DOI: 10.1523/Jneurosci.16-14-04449.1996  0.387
1993 Kang U, Fisher L, Joh T, O'Malley K, Gage F. Regulation of dopamine production by genetically modified primary fibroblasts The Journal of Neuroscience. 13: 5203-5211. DOI: 10.1523/Jneurosci.13-12-05203.1993  0.395
1992 Gage FH, Kang UJ, Fisher LJ. Intracerebral grafting in the dopaminergic system: issues and controversy. Current Opinion in Neurobiology. 1: 414-9. PMID 1821685 DOI: 10.1016/0959-4388(91)90063-D  0.365
1992 Kang UJ, Park DH, Wessel T, Baker H, Joh TH. DOPA-decarboxylation in the striata of rats with unilateral substantia nigra lesions Neuroscience Letters. 147: 53-57. PMID 1480324 DOI: 10.1016/0304-3940(92)90773-Z  0.428
1991 Chen LS, Ray J, Fisher LJ, Kawaja MD, Schinstine M, Kang UJ, Gage FH. Cellular replacement therapy for neurologic disorders: potential of genetically engineered cells. Journal of Cellular Biochemistry. 45: 252-7. PMID 2066374 DOI: 10.1002/Jcb.240450305  0.33
1990 Park DH, Kang UJ, Moskowitz CB, Burke RE, Joh TH, Fahn S. Dopamine beta-hydroxylase activity in cerebrospinal fluid of idiopathic torsion dystonia. Neurology. 40: 1626-8. PMID 2215959 DOI: 10.1212/Wnl.40.10.1626  0.319
1989 Burke RE, Kang UJ, Jankovic J, Miller LG, Fahn S. Tardive akathisia: an analysis of clinical features and response to open therapeutic trials. Movement Disorders : Official Journal of the Movement Disorder Society. 4: 157-75. PMID 2567492 DOI: 10.1002/Mds.870040208  0.322
1989 Kang UJ, Fahn S, Schwarz H, Shoulson I, Vallejos H, Goldman J. Case 1, 1989: juvenile-onset parkinsonism, dystonia, and pyramidal tract signs. Movement Disorders : Official Journal of the Movement Disorder Society. 4: 363-70. PMID 2530440 DOI: 10.1002/Mds.870040414  0.316
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