| Year |
Citation |
Score |
| 2023 |
Misra P, Tischer A, Lampe L, Pierluissi-Ruiz V, Dick CJ, Bragantini B, Kormshchikov N, Auton M, Ramirez-Alvarado M. Biophysical characterization of human-cell-expressed, full-length κI O18/O8, AL-09, λ6a, and Wil immunoglobulin light chains. Biochimica Et Biophysica Acta. Proteins and Proteomics. 140993. PMID 38169170 DOI: 10.1016/j.bbapap.2023.140993 |
0.332 |
|
| 2021 |
Misra P, Ramirez-Alvarado M. Early events in light chain aggregation at physiological pH reveal new insights on assembly, stability, and aggregate dissociation. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-12. PMID 33533277 DOI: 10.1080/13506129.2021.1877129 |
0.357 |
|
| 2019 |
Jordan TL, Maar K, Redhage KR, Misra P, Blancas-Mejia LM, Dick CJ, Wall JS, Williams A, Dietz AB, van Wijnen AJ, Lin Y, Ramirez-Alvarado M. Light chain amyloidosis induced inflammatory changes in cardiomyocytes and adipose-derived mesenchymal stromal cells. Leukemia. PMID 31796914 DOI: 10.1038/S41375-019-0640-4 |
0.425 |
|
| 2019 |
Sidana S, Larson DP, Greipp PT, He R, McPhail ED, Dispenzieri A, Murray DL, Dasari S, Ansell SM, Muchtar E, Gonsalves WI, Kourelis TV, Ramirez-Alvarado M, Kapoor P, Rajkumar SV, et al. IgM AL amyloidosis: delineating disease biology and outcomes with clinical, genomic and bone marrow morphological features. Leukemia. PMID 31780812 DOI: 10.1038/S41375-019-0667-6 |
0.316 |
|
| 2019 |
Misra P, Blancas-Mejia LM, Ramirez-Alvarado M. Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains. Biochemistry. PMID 31287666 DOI: 10.1021/Acs.Biochem.9B00311 |
0.466 |
|
| 2019 |
Blancas-Mejia LM, Misra P, Dick CJ, Marin-Argany M, Redhage KR, Cooper SA, Ramirez-Alvarado M. Assays for Light Chain Amyloidosis Formation and Cytotoxicity. Methods in Molecular Biology (Clifton, N.J.). 1873: 123-153. PMID 30341607 DOI: 10.1007/978-1-4939-8820-4_8 |
0.393 |
|
| 2019 |
Kourelis T, Dasari S, Fayyaz AU, Grogan M, Ramirez-Alvarado M, Redfield M, abou Ezzeddine OF, Dispenzieri A, McPhail ED. A Proteomic Atlas of Cardiac Amyloidosis Blood. 134: 1790-1790. DOI: 10.1182/Blood-2019-124802 |
0.413 |
|
| 2019 |
Sidana S, Dasari S, Kourelis T, Dispenzieri A, Murray DL, King RL, McPhail ED, Ramirez-Alvarado M, Kumar SK, Gertz MA. Immunoglobulin Variable Gene Region (IGVL) Usage Correlates with Distinct Clinical Presentation in IgM Versus Non-IgM Light Chain Amyloidosis Blood. 134: 1770-1770. DOI: 10.1182/Blood-2019-121714 |
0.357 |
|
| 2018 |
Blancas-Mejia LM, Misra P, Dick CJ, Cooper SA, Redhage KR, Bergman MR, Jordan TL, Maar K, Ramirez-Alvarado M. Immunoglobulin light chain amyloid aggregation. Chemical Communications (Cambridge, England). PMID 30087961 DOI: 10.1039/C8Cc04396E |
0.502 |
|
| 2018 |
Redhage K, Dick C, Lin Y, Marin-Argany M, Williams A, Wall JS, Ramirez-Alvarado M. Cardiac Light Chain Amyloidosis, Understanding the Implications of Cellular Toxicity in a 3D Model Biophysical Journal. 114: 498a. DOI: 10.1016/J.Bpj.2017.11.2728 |
0.314 |
|
| 2018 |
Misra P, Blancas Mejia L, Ramirez-Alvarado M. Structural Insights into Aggregation Mechanism of Immunoglobulin Light Chain Variable Domain Biophysical Journal. 114: 427a. DOI: 10.1016/J.Bpj.2017.11.2366 |
0.391 |
|
| 2017 |
Lin Y, Marin-Argany M, Dick CJ, Redhage KR, Blancas-Mejia LM, Bulur P, Butler GW, Deeds MC, Madden BJ, Williams A, Wall JS, Dietz A, Ramirez-Alvarado M. Mesenchymal stromal cells protect human cardiomyocytes from amyloid fibril damage. Cytotherapy. PMID 29037943 DOI: 10.1016/J.Jcyt.2017.08.021 |
0.452 |
|
| 2017 |
Blancas-Mejía LM, Martin EB, Williams A, Wall JS, Ramirez-Alvarado M. Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients. Biophysical Chemistry. PMID 28916410 DOI: 10.1016/J.Bpc.2017.08.011 |
0.453 |
|
| 2017 |
Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia L, Kennel SJ, Wall JS. Recruitment of human light chain proteins by synthetic fibrils is dependent on disease state and may be used to predict amyloidogenic propensity. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 24: 24-25. PMID 28434355 DOI: 10.1080/13506129.2017.1295374 |
0.401 |
|
| 2017 |
Gade Malmos K, Blancas-Mejia LM, Weber B, Buchner J, Ramirez-Alvarado M, Naiki H, Otzen D. ThT 101: a primer on the use of thioflavin T to investigate amyloid formation. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-16. PMID 28393556 DOI: 10.1080/13506129.2017.1304905 |
0.376 |
|
| 2017 |
Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia LM, Lands RH, Kennel SJ, Wall JS. Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity. Plos One. 12: e0174152. PMID 28350808 DOI: 10.1371/Journal.Pone.0174152 |
0.467 |
|
| 2017 |
Ramirez-Alvarado M, Barnidge DR, Murray DL, Dispenzieri A, Marin-Argany M, Dick CJ, Cooper SA, Nasr SH, Ward CJ, Dasari S, Jiménez-Zepeda VH, Leung N. Assessment of renal response with urinary exosomes in patients with AL amyloidosis: A proof of concept. American Journal of Hematology. PMID 28295502 DOI: 10.1002/Ajh.24717 |
0.403 |
|
| 2017 |
Piehl DW, Blancas-Mejía LM, Wall JS, Kennel SJ, Ramirez-Alvarado M, Rienstra CM. Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini. Acs Omega. 2: 712-720. PMID 28261692 DOI: 10.1021/acsomega.6b00494 |
0.368 |
|
| 2017 |
Blancas-Mejía LM, Misra P, Ramirez-Alvarado M. Differences in protein concentration dependence for nucleation and elongation in light chain amyloid formation. Biochemistry. PMID 28074646 DOI: 10.1021/Acs.Biochem.6B01043 |
0.477 |
|
| 2017 |
Piehl D, Blancas-Mejia L, Ramirez-Alvarado M, Rienstra C. Solid-state NMR 13C and 15N chemical shift assignments for AL-09 VL immunoglobulin light chain fibrils Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr26879 |
0.366 |
|
| 2017 |
Ramirez-Alvarado M, Marin-Argany M, Dick CJ, Blancas-Mejia LM, Misra P, Lin Y, Williams A, Wall JS. From Native to Amyloid in the Test Tube and in Cells: A Journey of Misbehaving Antibodies Biophysical Journal. 112: 15a. DOI: 10.1016/J.Bpj.2016.11.115 |
0.515 |
|
| 2016 |
Kourelis TV, Dasari S, Theis JD, Ramirez-Alvarado M, Kurtin PJ, Gertz MA, Zeldenrust SR, Zenka RM, Dogan A, Dispenzieri A. Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light chain amyloidosis by mass spectrometry. Blood. PMID 27856462 DOI: 10.1182/Blood-2016-10-743997 |
0.353 |
|
| 2016 |
Piehl DW, Blancas-Mejía LM, Ramirez-Alvarado M, Rienstra CM. Solid-state NMR chemical shift assignments for AL-09 VL immunoglobulin light chain fibrils. Biomolecular Nmr Assignments. PMID 27771830 DOI: 10.1007/S12104-016-9718-3 |
0.489 |
|
| 2016 |
Marin-Argany M, Lin Y, Misra P, Williams A, Wall JS, Howell KG, Elsbernd LR, McClure M, Ramirez-Alvarado M. Cell Damage in Light Chain Amyloidosis: Fibril Internalization, Toxicity and Cell-Mediated Seeding. The Journal of Biological Chemistry. PMID 27462073 DOI: 10.1074/Jbc.M116.736736 |
0.489 |
|
| 2016 |
Blancas-Mejía LM, Ramirez-Alvarado M. Recruitment of Light Chains by Homologous and Heterologous Fibrils Shows Distinctive Kinetic and Conformational Specificity. Biochemistry. PMID 27158939 DOI: 10.1021/Acs.Biochem.6B00090 |
0.458 |
|
| 2016 |
Misra PP, Blancas-Mejia LM, Ramirez-Alvarado M. Insights into the Genesis of Light Chain Amyloid Assembly Biophysical Journal. 110: 401. DOI: 10.1016/J.Bpj.2015.11.2164 |
0.466 |
|
| 2016 |
Marin-Argany M, Lin Y, Wall JS, Elsbernd LR, McClure M, Ramirez-Alvarado M. Light Chain Amyloid Fibrils Act as a Recruitment Point for Soluble Protein and Reveal their Cytotoxic Potential in Human Cardiomyocytes Biophysical Journal. 110: 400a-401a. DOI: 10.1016/J.Bpj.2015.11.2163 |
0.496 |
|
| 2016 |
Blancas-Mejia LM, Ramirez-Alvarado M. Mechanism of Light Chain Amyloid Fibril Formation: Seeding-Nucleation and Polymerization Amyloid Formation and the Cross-Seeding Phenomenon Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2153 |
0.404 |
|
| 2015 |
McWilliams-Koeppen HP, Foster JS, Hackenbrack N, Ramirez-Alvarado M, Donohoe D, Williams A, Macy S, Wooliver C, Wortham D, Morrell-Falvey J, Foster CM, Kennel SJ, Wall JS. Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes. Plos One. 10: e0137716. PMID 26393799 DOI: 10.1371/Journal.Pone.0137716 |
0.453 |
|
| 2015 |
Marin-Argany M, Güell-Bosch J, Blancas-Mejía LM, Villegas S, Ramirez-Alvarado M. Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils. Protein Science : a Publication of the Protein Society. 24: 1829-40. PMID 26300552 DOI: 10.1002/Pro.2790 |
0.487 |
|
| 2015 |
Blancas-Mejía LM, Horn TJ, Marin-Argany M, Auton M, Tischer A, Ramirez-Alvarado M. Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding. Biophysical Chemistry. 207: 13-20. PMID 26263488 DOI: 10.1016/J.Bpc.2015.07.005 |
0.495 |
|
| 2015 |
Blancas-Mejía LM, Hammernik J, Marin-Argany M, Ramirez-Alvarado M. Differential effects on light chain amyloid formation depend on mutations and type of glycosaminoglycans. The Journal of Biological Chemistry. 290: 4953-65. PMID 25538238 DOI: 10.1074/Jbc.M114.615401 |
0.49 |
|
| 2014 |
Barnidge DR, Dasari S, Ramirez-Alvarado M, Fontan A, Willrich MA, Tschumper RC, Jelinek DF, Snyder MR, Dispenzieri A, Katzmann JA, Murray DL. Phenotyping polyclonal kappa and lambda light chain molecular mass distributions in patient serum using mass spectrometry. Journal of Proteome Research. 13: 5198-205. PMID 25134970 DOI: 10.1021/Pr5005967 |
0.317 |
|
| 2014 |
Dai H, Pang YP, Ramirez-Alvarado M, Kaufmann SH. Evaluation of the BH3-only protein Puma as a direct Bak activator. The Journal of Biological Chemistry. 289: 89-99. PMID 24265320 DOI: 10.1074/Jbc.M113.505701 |
0.326 |
|
| 2014 |
Truran S, Weissig V, Ramirez-Alvarado M, Franco DA, Burciu C, Georges J, Murarka S, Okoth WA, Schwab S, Hari P, Migrino RQ. Nanoliposomes protect against AL amyloid light chain protein-induced endothelial injury. Journal of Liposome Research. 24: 69-73. PMID 24236475 DOI: 10.3109/08982104.2013.838258 |
0.381 |
|
| 2014 |
Blancas-MejÃa LM, Tischer A, Thompson JR, Tai J, Wang L, Auton M, Ramirez-Alvarado M. Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations. Journal of Molecular Biology. 426: 347-61. PMID 24157440 DOI: 10.1016/J.Jmb.2013.10.016 |
0.471 |
|
| 2014 |
Kourelis T, Dasari S, Theis JD, Ramirez-Alvarado M, Kurtin PJ, Gertz MA, Zeldensrust SR, Dogan A, Dispenzieri A. Clarifying immunoglobulin gene usage in immunoglobulin light chain amyloidosis by mass spectrometry of amyloid in clinical tissue specimens. Journal of Clinical Oncology. 32: 8605-8605. DOI: 10.1200/Jco.2014.32.15_Suppl.8605 |
0.365 |
|
| 2014 |
Kourelis T, Dasari S, Kurtin PJ, Ramirez-Alvarado M, Zeldenrust SR, Theis JD, Gertz MA, Dogan A, Dispenzieri A. Immunoglobulin Variable Region Family Usage and Outcomes of Patients with Systemic Light Chain Amyloidosis Blood. 124: 3402-3402. DOI: 10.1182/Blood.V124.21.3402.3402 |
0.347 |
|
| 2013 |
Poshusta TL, Katoh N, Gertz MA, Dispenzieri A, Ramirez-Alvarado M. Thermal stability threshold for amyloid formation in light chain amyloidosis. International Journal of Molecular Sciences. 14: 22604-17. PMID 24248061 DOI: 10.3390/Ijms141122604 |
0.474 |
|
| 2013 |
Levinson RT, Olatoye OO, Randles EG, Howell KG, DiCostanzo AC, Ramirez-Alvarado M. Role of mutations in the cellular internalization of amyloidogenic light chains into cardiomyocytes. Scientific Reports. 3: 1278. PMID 23417147 DOI: 10.1038/Srep01278 |
0.469 |
|
| 2013 |
Bergen HR, Murray DL, Jelinek DF, Tschumper RC, Barnidge DR, Ramirez-Alvarado M, Dasari S. Monitoring Minimum Residual Disease In Multiple Myeloma Patients By LC-MS/MS Blood. 122: 3152-3152. DOI: 10.1182/Blood.V122.21.3152.3152 |
0.347 |
|
| 2013 |
Mereuta OM, Dasari S, Theis JD, Vrana JA, Grogg KL, Gertz MA, Zeldenrust SR, Dispenzieri A, Ramirez-Alvarado M, Jelinek DF, Kurtin PJ, Dogan A. Mass Spectrometry-Based Proteomics Reveals Distinct Immunoglobulin Light Chain Variable Region Usage In Systemic Versus Localized AL Amyloidosis Blood. 122: 3142-3142. DOI: 10.1182/Blood.V122.21.3142.3142 |
0.354 |
|
| 2012 |
Ramirez-Alvarado M. Amyloid formation in light chain amyloidosis. Current Topics in Medicinal Chemistry. 12: 2523-33. PMID 23339305 DOI: 10.2174/1568026611212220007 |
0.483 |
|
| 2012 |
Leung N, Gertz M, Kyle RA, Fervenza FC, Irazabal MV, Eirin A, Kumar S, Cha SS, Rajkumar SV, Lacy MQ, Zeldenrust SR, Buadi FK, Hayman SR, Nasr SH, Sethi S, ... Ramirez-Alvarado M, et al. Urinary albumin excretion patterns of patients with cast nephropathy and other monoclonal gammopathy-related kidney diseases. Clinical Journal of the American Society of Nephrology : Cjasn. 7: 1964-8. PMID 23024162 DOI: 10.2215/Cjn.11161111 |
0.358 |
|
| 2012 |
DiCostanzo AC, Thompson JR, Peterson FC, Volkman BF, Ramirez-Alvarado M. Tyrosine residues mediate fibril formation in a dynamic light chain dimer interface. The Journal of Biological Chemistry. 287: 27997-8006. PMID 22740699 DOI: 10.1074/Jbc.M112.362921 |
0.464 |
|
| 2012 |
Ramirez-Alvarado M, Ward CJ, Huang BQ, Gong X, Hogan MC, Madden BJ, Charlesworth MC, Leung N. Differences in immunoglobulin light chain species found in urinary exosomes in light chain amyloidosis (Al). Plos One. 7: e38061. PMID 22723846 DOI: 10.1371/Journal.Pone.0038061 |
0.394 |
|
| 2012 |
Poduslo JF, Howell KG, Olson NC, Ramirez-Alvarado M, Kandimalla KK. Alzheimer's disease amyloid β-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils. Biochemistry. 51: 3993-4003. PMID 22545812 DOI: 10.1021/Bi300275G |
0.337 |
|
| 2012 |
Kumar SK, Dispenzieri A, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Zeldenrust SR, Ramirez-Alvarado M, Kapoor P, Hogan W, Rajkumar SV, Gertz MA. Doxycycline Used As Post Transplant Antibacterial Prophylaxis Improves Survival in Patients with Light Chain Amyloidosis Undergoing Autologous Stem Cell Transplantation. Blood. 120: 3138-3138. DOI: 10.1182/Blood.V120.21.3138.3138 |
0.303 |
|
| 2012 |
DiCostanzo AC, Thompson JR, Peterson FC, Volkman BF, Ramirez-Alvarado M. Tyrosine residues mediate fibril formation in a dynamic light chain dimer interface (The Journal of Biological Chemistry (2012) 287 (27997-28006)) Journal of Biological Chemistry. 287: 35541. DOI: 10.1074/Jbc.A112.362921 |
0.396 |
|
| 2012 |
Poduslo J, Howell K, Olson N, Ramirez-Alvarado M. P3-048: Alzheimer's disease beta-amyloid protein mutations and deletions that define neuronal binding/internalization as early-state nonfibrillar/fibrillar aggregates and late-state fibrils Alzheimer's & Dementia. 8: P472-P472. DOI: 10.1016/J.Jalz.2012.05.2124 |
0.384 |
|
| 2011 |
Katoh N, Poshusta TL, Manske MK, Dispenzieri A, Gertz MA, Abraham RS, Ramirez-Alvarado M. A reappraisal of immunoglobulin variable gene primers and its impact on assessing clonal relationships between PB B cells and BM plasma cells in AL amyloidosis. Journal of Clinical Immunology. 31: 1029-37. PMID 21909811 DOI: 10.1007/S10875-011-9582-Y |
0.336 |
|
| 2011 |
Martin DJ, Ramirez-Alvarado M. Glycosaminoglycans promote fibril formation by amyloidogenic immunoglobulin light chains through a transient interaction. Biophysical Chemistry. 158: 81-9. PMID 21640469 DOI: 10.1016/J.Bpc.2011.05.011 |
0.459 |
|
| 2010 |
Sikkink LA, Ramirez-Alvarado M. Cytotoxicity of amyloidogenic immunoglobulin light chains in cell culture. Cell Death & Disease. 1: e98. PMID 21368874 DOI: 10.1038/cddis.2010.75 |
0.367 |
|
| 2010 |
Martin DJ, Ramirez-Alvarado M. Comparison of amyloid fibril formation by two closely related immunoglobulin light chain variable domains. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 17: 129-36. PMID 21077798 DOI: 10.3109/13506129.2010.530081 |
0.504 |
|
| 2010 |
Kumar S, Dispenzieri A, Katzmann JA, Larson DR, Colby CL, Lacy MQ, Hayman SR, Buadi FK, Leung N, Zeldenrust SR, Ramirez-Alvarado M, Clark RJ, Kyle RA, Rajkumar SV, Gertz MA. Serum immunoglobulin free light-chain measurement in primary amyloidosis: prognostic value and correlations with clinical features. Blood. 116: 5126-9. PMID 20798235 DOI: 10.1182/Blood-2010-06-290668 |
0.391 |
|
| 2010 |
Peterson FC, Baden EM, Owen BA, Volkman BF, Ramirez-Alvarado M. A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface. Structure (London, England : 1993). 18: 563-70. PMID 20462490 DOI: 10.1016/J.Str.2010.02.012 |
0.476 |
|
| 2010 |
Lorenz EC, Sethi S, Poshusta TL, Ramirez-Alvarado M, Kumar S, Lager DJ, Fervenza FC, Leung N. Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 25: 1340-3. PMID 20061318 DOI: 10.1093/Ndt/Gfp735 |
0.31 |
|
| 2010 |
Chadli A, Felts SJ, Wang Q, Sullivan WP, Botuyan MV, Fauq A, Ramirez-Alvarado M, Mer G. Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. The Journal of Biological Chemistry. 285: 4224-31. PMID 19996313 DOI: 10.1074/Jbc.M109.081018 |
0.315 |
|
| 2010 |
Volkman BF, Peterson FC, Ramirez-Alvarado M, Baden EM. Solution Structure Of The Al-09 H87Y Immunoglobulin Light Chain Variable Domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kqn/Pdb |
0.379 |
|
| 2010 |
Volkman BF, Peterson FC, Ramirez-Alvarado M, Baden EM. Solution structure of the KI O18/O8 Y87H immunoglobulin light chain variable domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kqm/Pdb |
0.308 |
|
| 2010 |
Murray DL, Theis JD, Vrana JA, Ramirez-Alvarado M, Abraham R, Dispenzieri A, Katzmann JA, Dogan A. Proteomic Analysis of Immunoglobulin Light Chains (LC) In AL Amyloidosis Shows That the Sequence of Clonal LC Secreted by the Neoplastic Plasma Cells Is Identical to the LC Deposited In the Amyloid Plaques Blood. 116: 1909-1909. DOI: 10.1182/Blood.V116.21.1909.1909 |
0.411 |
|
| 2010 |
Martin D, Ramirez-Alvarado M. Structural and Functional Analysis of Amyloid Fibril Formation by Two Closely Related Light Chains Biophysical Journal. 98: 252a. DOI: 10.1016/J.Bpj.2009.12.1371 |
0.518 |
|
| 2009 |
Baden EM, Sikkink LA, Ramirez-Alvarado M. Light chain amyloidosis - current findings and future prospects. Current Protein & Peptide Science. 10: 500-8. PMID 19538145 DOI: 10.2174/138920309789351949 |
0.502 |
|
| 2009 |
Weaver TM, Smith JA, Hocking JM, Bailey LJ, Wawrzyn GT, Howard DR, Sikkink LA, Ramirez-Alvarado M, Thompson JR. Structural and functional studies of truncated hemolysin A from Proteus mirabilis. The Journal of Biological Chemistry. 284: 22297-309. PMID 19494116 DOI: 10.1074/Jbc.M109.014431 |
0.384 |
|
| 2009 |
Poshusta TL, Sikkink LA, Leung N, Clark RJ, Dispenzieri A, Ramirez-Alvarado M. Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis. Plos One. 4: e5169. PMID 19365555 DOI: 10.1371/Journal.Pone.0005169 |
0.456 |
|
| 2009 |
Randles EG, Thompson JR, Martin DJ, Ramirez-Alvarado M. Structural alterations within native amyloidogenic immunoglobulin light chains. Journal of Molecular Biology. 389: 199-210. PMID 19361523 DOI: 10.1016/J.Jmb.2009.04.010 |
0.507 |
|
| 2009 |
Kaplan B, Ramirez-Alvarado M, Sikkink L, Golderman S, Dispenzieri A, Livneh A, Gallo G. Free light chains in plasma of patients with light chain amyloidosis and non-amyloid light chain deposition disease. High proportion and heterogeneity of disulfide-linked monoclonal free light chains as pathogenic features of amyloid disease. British Journal of Haematology. 144: 705-15. PMID 19076171 DOI: 10.1111/J.1365-2141.2008.07522.X |
0.459 |
|
| 2009 |
Kumar S, Gertz MA, Lacy MQ, Hayman SR, Buadi F, Zeldenrust SR, Ramirez-Alvarado M, Leung N, Dispenzieri A. Changes in Serum Free Light Chain Rather Than Intact Monoclonal Immunoglobulin Levels Predict Outcome with Therapy in Patients with Light Chain Amyloidosis. Blood. 114: 747-747. DOI: 10.1182/Blood.V114.22.747.747 |
0.4 |
|
| 2009 |
Ramirez-Alvarado M, Ward CJ, Huang BQ, Gong X, Hogan MC, Madden BJ, Charlesworth C, Dispenzieri A, Gertz MA, Leung N. Detection of High Molecular Weight Light Chain Oligomers in Urinary Exosomes of Patients with AL Amyloidosis. Blood. 114: 4886-4886. DOI: 10.1182/Blood.V114.22.4886.4886 |
0.413 |
|
| 2009 |
Kumar S, Dispenzieri A, Lacy MQ, Hayman S, Buadi F, Zeldenrust SR, Leung N, Ramirez-Alvarado M, Kyle RA, Rajkumar SV, Gertz MA. A Novel Prognostic Staging System for Light Chain Amyloidosis (AL) Incorporating Markers of Plasma Cell Burden and Organ Involvement. Blood. 114: 2797-2797. DOI: 10.1182/Blood.V114.22.2797.2797 |
0.36 |
|
| 2008 |
Ramirez-Alvarado M. Principles of protein misfolding. Progress in Molecular Biology and Translational Science. 84: 115-60. PMID 19121701 DOI: 10.1016/S0079-6603(08)00404-2 |
0.407 |
|
| 2008 |
Baden EM, Randles EG, Aboagye AK, Thompson JR, Ramirez-Alvarado M. Structural insights into the role of mutations in amyloidogenesis. The Journal of Biological Chemistry. 283: 30950-6. PMID 18768467 DOI: 10.1074/Jbc.M804822200 |
0.393 |
|
| 2008 |
Arendt BK, Ramirez-Alvarado M, Sikkink LA, Keats JJ, Ahmann GJ, Dispenzieri A, Fonseca R, Ketterling RP, Knudson RA, Mulvihill EM, Tschumper RC, Wu X, Zeldenrust SR, Jelinek DF. Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2. Blood. 112: 1931-41. PMID 18567838 DOI: 10.1182/Blood-2008-03-143040 |
0.402 |
|
| 2008 |
Ramakrishnan M, Wengenack TM, Kandimalla KK, Curran GL, Gilles EJ, Ramirez-Alvarado M, Lin J, Garwood M, Jack CR, Poduslo JF. Selective contrast enhancement of individual Alzheimer's disease amyloid plaques using a polyamine and Gd-DOTA conjugated antibody fragment against fibrillar Abeta42 for magnetic resonance molecular imaging. Pharmaceutical Research. 25: 1861-72. PMID 18443900 DOI: 10.1007/S11095-008-9600-9 |
0.301 |
|
| 2008 |
Baden EM, Owen BA, Peterson FC, Volkman BF, Ramirez-Alvarado M, Thompson JR. Altered dimer interface decreases stability in an amyloidogenic protein. The Journal of Biological Chemistry. 283: 15853-60. PMID 18400753 DOI: 10.1074/Jbc.M705347200 |
0.467 |
|
| 2008 |
Sikkink LA, Ramirez-Alvarado M. Salts enhance both protein stability and amyloid formation of an immunoglobulin light chain. Biophysical Chemistry. 135: 25-31. PMID 18395318 DOI: 10.1016/J.Bpc.2008.02.019 |
0.465 |
|
| 2008 |
Sikkink LA, Ramirez-Alvarado M. Biochemical and aggregation analysis of Bence Jones proteins from different light chain diseases. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 15: 29-39. PMID 18266119 DOI: 10.1080/13506120701815324 |
0.493 |
|
| 2008 |
Kaplan B, Ramirez-Alvarado M, Dispenzieri A, Zeldenrust SR, Leung N, Livneh A, Gallo G. Isolation and biochemical characterization of plasma monoclonal free light chains in amyloidosis and multiple myeloma: a pilot study of intact and truncated forms of light chains and their charge properties. Clinical Chemistry and Laboratory Medicine : Cclm / Fescc. 46: 335-41. PMID 18254719 DOI: 10.1515/Cclm.2008.068 |
0.407 |
|
| 2007 |
Poduslo JF, Ramakrishnan M, Holasek SS, Ramirez-Alvarado M, Kandimalla KK, Gilles EJ, Curran GL, Wengenack TM. In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques. Journal of Neurochemistry. 102: 420-33. PMID 17596213 DOI: 10.1111/J.1471-4159.2007.04591.X |
0.308 |
|
| 2006 |
McLaughlin RW, De Stigter JK, Sikkink LA, Baden EM, Ramirez-Alvarado M. The effects of sodium sulfate, glycosaminoglycans, and Congo red on the structure, stability, and amyloid formation of an immunoglobulin light-chain protein. Protein Science : a Publication of the Protein Society. 15: 1710-22. PMID 16751605 DOI: 10.1110/Ps.051997606 |
0.496 |
|
| 2006 |
Kandimalla KK, Curran GL, Holasek SS, Gilles EJ, Wengenack TM, Ramirez-Alvarado M, Poduslo JF. Physiological and biophysical factors that influence Alzheimer's disease amyloid plaque targeting of native and putrescine modified human amyloid beta40. The Journal of Pharmacology and Experimental Therapeutics. 318: 17-25. PMID 16565169 DOI: 10.1124/Jpet.105.095711 |
0.346 |
|
| 2006 |
Carrigan PE, Sikkink LA, Smith DF, Ramirez-Alvarado M. Domain:domain interactions within Hop, the Hsp70/Hsp90 organizing protein, are required for protein stability and structure. Protein Science : a Publication of the Protein Society. 15: 522-32. PMID 16452615 DOI: 10.1110/Ps.051810106 |
0.307 |
|
| 2006 |
Arendt BK, Ahmann GJ, Mulvihill EM, Sikkink LA, Dispenzieri A, Ramirez-Alvarado M, Zeldenrust SR, Fonseca R, Jelinek DF. Establishment and Characterization of an Ig Lambda Secreting Cell Line from a Patient with AL Amyloidosis. Blood. 108: 3520-3520. DOI: 10.1182/Blood.V108.11.3520.3520 |
0.373 |
|
| 2005 |
Wang J, Gülich S, Bradford C, Ramirez-Alvarado M, Regan L. A twisted four-sheeted model for an amyloid fibril. Structure (London, England : 1993). 13: 1279-88. PMID 16154085 DOI: 10.1016/J.Str.2005.06.010 |
0.401 |
|
| 2005 |
Wang L, Nguyen TV, McLaughlin RW, Sikkink LA, Ramirez-Alvarado M, Weinshilboum RM. Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. Proceedings of the National Academy of Sciences of the United States of America. 102: 9394-9. PMID 15967990 DOI: 10.1073/Pnas.0502352102 |
0.314 |
|
| 2004 |
Abraham RS, Geyer SM, Ramírez-Alvarado M, Price-Troska TL, Gertz MA, Fonseca R. Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL). Journal of Clinical Immunology. 24: 340-53. PMID 15163890 DOI: 10.1023/B:Joci.0000029113.68758.9F |
0.463 |
|
| 2003 |
Khurana R, Ionescu-Zanetti C, Pope M, Li J, Nielson L, Ramírez-Alvarado M, Regan L, Fink AL, Carter SA. A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy. Biophysical Journal. 85: 1135-44. PMID 12885658 DOI: 10.1016/S0006-3495(03)74550-0 |
0.381 |
|
| 2003 |
Ramírez-Alvarado M, Cocco MJ, Regan L. Mutations in the B1 domain of protein G that delay the onset of amyloid fibril formation in vitro. Protein Science : a Publication of the Protein Society. 12: 567-76. PMID 12592027 DOI: 10.1110/Ps.0227403 |
0.387 |
|
| 2002 |
Ramírez-Alvarado M, Regan L. Does the location of a mutation determine the ability to form amyloid fibrils? Journal of Molecular Biology. 323: 17-22. PMID 12368095 DOI: 10.1016/S0022-2836(02)00840-9 |
0.306 |
|
| 2001 |
López de la Paz M, Lacroix E, Ramírez-Alvarado M, Serrano L. Computer-aided design of beta-sheet peptides. Journal of Molecular Biology. 312: 229-46. PMID 11545599 DOI: 10.1006/Jmbi.2001.4918 |
0.466 |
|
| 2001 |
Ramírez-Alvarado M, Blanco FJ, Serrano L. Elongation of the BH8 beta-hairpin peptide: Electrostatic interactions in beta-hairpin formation and stability. Protein Science : a Publication of the Protein Society. 10: 1381-92. PMID 11420440 DOI: 10.1110/Ps.52901 |
0.536 |
|
| 2001 |
Nesmelova I, Krushelnitsky A, Idiyatullin D, Blanco F, Ramirez-Alvarado M, Daragan VA, Serrano L, Mayo KH. Conformational exchange on the microsecond time scale in alpha-helix and beta-hairpin peptides measured by 13C NMR transverse relaxation. Biochemistry. 40: 2844-53. PMID 11258895 DOI: 10.1021/Bi001293B |
0.497 |
|
| 2000 |
Ramirez-Alvarado M, Merkel JS, Regan L. A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. 97: 8979-84. PMID 10908649 DOI: 10.1073/Pnas.150091797 |
0.459 |
|
| 1999 |
Ramírez-Alvarado M, Kortemme T, Blanco FJ, Serrano L. Beta-hairpin and beta-sheet formation in designed linear peptides. Bioorganic & Medicinal Chemistry. 7: 93-103. PMID 10199660 DOI: 10.1016/S0968-0896(98)00215-6 |
0.659 |
|
| 1998 |
Kortemme T, Ramírez-Alvarado M, Serrano L. Design of a 20-amino acid, three-stranded beta-sheet protein. Science (New York, N.Y.). 281: 253-6. PMID 9657719 DOI: 10.1126/Science.281.5374.253 |
0.661 |
|
| 1998 |
Ramirez-Alvarado M, Daragan VA, Serrano L, Mayo KH. Motional dynamics of residues in a beta-hairpin peptide measured by 13C-NMR relaxation. Protein Science : a Publication of the Protein Society. 7: 720-9. PMID 9541404 DOI: 10.1002/Pro.5560070321 |
0.428 |
|
| 1998 |
Blanco F, Ramírez-Alvarado M, Serrano L. Formation and stability of beta-hairpin structures in polypeptides. Current Opinion in Structural Biology. 8: 107-11. PMID 9519303 DOI: 10.1016/S0959-440X(98)80017-1 |
0.547 |
|
| 1997 |
Ramírez-Alvarado M, Blanco FJ, Niemann H, Serrano L. Role of beta-turn residues in beta-hairpin formation and stability in designed peptides. Journal of Molecular Biology. 273: 898-912. PMID 9367780 DOI: 10.1006/Jmbi.1997.1347 |
0.492 |
|
| 1997 |
Ramírez-Alvarado M, Serrano L, Blanco FJ. Conformational analysis of peptides corresponding to all the secondary structure elements of protein L B1 domain: secondary structure propensities are not conserved in proteins with the same fold. Protein Science : a Publication of the Protein Society. 6: 162-74. PMID 9007989 DOI: 10.1002/pro.5560060119 |
0.493 |
|
| 1996 |
Ramírez-Alvarado M, Blanco FJ, Serrano L. De novo design and structural analysis of a model beta-hairpin peptide system. Nature Structural Biology. 3: 604-12. PMID 8673604 DOI: 10.1038/Nsb0796-604 |
0.557 |
|
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