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Matthew T. Auton, Ph.D. - Publications

Affiliations: 
2004 University of Texas Medical Branch, Galveston, TX 
Area:
Biochemistry, General Biophysics
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42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Tischer A, Moon-Tasson LM, Auton M. Removal of the vicinal disulfide enhances the platelet capturing function of Von Willebrand Factor. Blood. PMID 36603190 DOI: 10.1182/blood.2022018803  0.372
2021 Bury L, Falcinelli E, Kuchi Bhotla H, Mezzasoma AM, Guglielmini G, Tischer A, Moon-Tasson L, Auton M, Gresele P. A p.Arg127Gln variant in GPIbα LRR5 allosterically enhances affinity for VWF: a novel form of platelet-type VWD. Blood Advances. PMID 34619770 DOI: 10.1182/bloodadvances.2021005463  0.307
2020 Huck V, Chen PC, Xu ER, Tischer A, Klemm U, Aponte-Santamaría C, Mess C, Obser T, Kutzki F, König G, Denis C, Gräter F, Wilmanns M, Auton M, Schneider SW, et al. Gain-of-function variant p.Pro2555Arg of von Willebrand factor increases aggregate size through altering stem dynamics. Thrombosis and Haemostasis. PMID 33385180 DOI: 10.1055/a-1344-4405  0.316
2019 Tischer A, Brehm MA, Machha VR, Moon-Tasson L, Benson LM, Nelton KJ, Leger RR, Obser T, Martinez-Vargas M, Whitten ST, Chen D, Pruthi RK, Bergen HR, Cruz MA, Schneppenheim R, ... Auton M, et al. zEvidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease. Journal of Molecular Biology. PMID 31628947 DOI: 10.1016/J.Jmb.2019.09.022  0.465
2019 Tischer A, Machha VR, Moon-Tasson L, Benson LM, Auton M. Glycosylation Sterically Inhibits Platelet Adhesion to von Willebrand Factor without Altering Intrinsic Conformational Dynamics. Journal of Thrombosis and Haemostasis : Jth. PMID 31479573 DOI: 10.1111/Jth.14628  0.436
2019 Tischer A, Machha VR, Moon-Tasson L, Auton M. Platelet-Type von Willebrand Disease: Local Disorder of the Platelet GPIbα β-Switch Drives High-affinity Binding to von Willebrand Factor. Journal of Thrombosis and Haemostasis : Jth. PMID 31448872 DOI: 10.1111/Jth.14597  0.351
2019 Tischer A, Brown M, Schleif RF, Auton M. Arabinose Alters Both Local and Distal H-D Exchange Rates in the Escherichia coli AraC Transcriptional Regulator. Biochemistry. PMID 31199144 DOI: 10.1021/Acs.Biochem.9B00389  0.389
2018 Schneppenheim R, Hellermann N, Brehm MA, Klemm U, Obser T, Huck V, Schneider SW, Denis CV, Tischer A, Auton M, März W, Xu ER, Wilmanns M, Zotz RB. The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction. Blood. PMID 30366922 DOI: 10.1182/Blood-2018-04-843425  0.36
2018 O'Neil PT, Machen AJ, Deatherage BC, Trecazzi C, Tischer A, Machha VR, Auton MT, Baldwin MR, White TA, Fisher MT. The Chaperonin GroEL: A Versatile Tool for Applied Biotechnology Platforms. Frontiers in Molecular Biosciences. 5: 46. PMID 29868607 DOI: 10.3389/Fmolb.2018.00046  0.454
2018 Tischer A, Machha VR, Rösgen J, Auton M. "Cooperative collapse" of the denatured state revealed through Clausius-Clapeyron analysis of protein denaturation phase diagrams. Biopolymers. PMID 29457634 DOI: 10.1002/Bip.23106  0.385
2017 Tischer A, Machha VR, Frontroth JP, Brehm MA, Obser T, Schneppenheim R, Mayne L, Walter Englander S, Auton M. Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping. Journal of Molecular Biology. PMID 28533135 DOI: 10.1016/J.Jmb.2017.05.013  0.464
2017 Blackburn PR, Tischer A, Zimmermann MT, Kemppainen JL, Sastry S, Knight Johnson AE, Cousin MA, Boczek NJ, Oliver G, Misra VK, Gavrilova RH, Lomberk GA, Auton M, Urrutia RA, Klee EW. A Novel Kleefstra Syndrome Associated Variant that Affects the Conserved TPLX Motif within the Ankyrin Repeat of EHMT1 Leads to Abnormal Protein Folding. The Journal of Biological Chemistry. PMID 28057753 DOI: 10.1074/Jbc.M116.770545  0.319
2016 Machha VR, Tischer A, Moon-Tasson L, Auton M. The von Willebrand Factor A1-Collagen III Interaction is Independent of Conformation and Type 2 von Willebrand Disease Phenotype. Journal of Molecular Biology. PMID 27889474 DOI: 10.1016/J.Jmb.2016.11.014  0.479
2016 Campbell JC, Tischer A, Machha V, Moon-Tasson L, Sankaran B, Kim C, Auton M. Data on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain. Data in Brief. 7: 1700-1706. PMID 27761512 DOI: 10.1016/J.Dib.2016.05.004  0.464
2016 Lea WA, O 'Neil PT, Machen AJ, Naik S, Chaudhuri TK, McGinn-Straub W, Tischer A, Auton MT, Burns JR, Baldwin MR, Khar KR, Karanicolas J, Fisher MT. Chaperonin-based biolayer interferometry to assess the kinetic stability of metastable, aggregation-prone proteins. Biochemistry. PMID 27505032 DOI: 10.1021/Acs.Biochem.6B00293  0.421
2016 Auton M. Untangling a Structurally Resolved Protein Folding Intermediate. Biophysical Journal. 110: 1205-6. PMID 27028629 DOI: 10.1016/J.Bpj.2016.01.028  0.375
2015 Tischer A, Campbell JC, Machha VR, Moon-Tasson L, Benson LM, Sankaran B, Kim C, Auton M. Mutational constraints on local unfolding inhibit the rheological adaptation of von Willebrand factor. The Journal of Biological Chemistry. PMID 26677223 DOI: 10.1074/Jbc.M115.703850  0.469
2015 Blancas-Mejía LM, Horn TJ, Marin-Argany M, Auton M, Tischer A, Ramirez-Alvarado M. Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding. Biophysical Chemistry. 207: 13-20. PMID 26263488 DOI: 10.1016/J.Bpc.2015.07.005  0.34
2015 Zimmermann MT, Tischer A, Whitten ST, Auton M. Structural origins of misfolding propensity in the platelet adhesive von willebrand factor A1 domain. Biophysical Journal. 109: 398-406. PMID 26200876 DOI: 10.1016/J.Bpj.2015.06.008  0.492
2014 Perez RB, Tischer A, Auton M, Whitten ST. Alanine and proline content modulate global sensitivity to discrete perturbations in disordered proteins. Proteins. 82: 3373-84. PMID 25244701 DOI: 10.1002/Prot.24692  0.37
2014 Tischer A, Madde P, Moon-Tasson L, Auton MT. Misfolding of vWF to pathologically disordered conformations impacts the severity of von Willebrand disease. Biophysical Journal. 107: 1185-1195. PMID 25185554 DOI: 10.1016/J.Bpj.2014.07.026  0.447
2014 Tischer A, Pultke H, Topf A, Auton M, Lange C, Lilie H. The effects of N-ethyl-N'-methyl imidazolium chloride on the solubility, stability and aggregation of tc-rPA. The Febs Journal. 281: 1738-49. PMID 24506586 DOI: 10.1111/Febs.12736  0.368
2014 Tischer A, Madde P, Blancas-Mejia LM, Auton M. A molten globule intermediate of the Von Willebrand factor A1 domain firmly tethers platelets under shear flow Proteins. 82: 867-878. PMID 24265179 DOI: 10.1002/Prot.24464  0.481
2014 Blancas-Mejía LM, Tischer A, Thompson JR, Tai J, Wang L, Auton M, Ramirez-Alvarado M. Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations. Journal of Molecular Biology. 426: 347-61. PMID 24157440 DOI: 10.1016/J.Jmb.2013.10.016  0.398
2014 Tischer A, Madde P, Tasson LM, Auton M. Misfolding Induced By the Mutations V1314D and F1369I Affects the Function and the Structure of the Von Willebrand A1-Domain Blood. 124: 1521-1521. DOI: 10.1182/Blood.V124.21.1521.1521  0.483
2013 Tischer A, Auton M. Urea-temperature phase diagrams capture the thermodynamics of denatured state expansion that accompany protein unfolding. Protein Science. 22: 1147-1160. PMID 23813497 DOI: 10.1002/Pro.2301  0.337
2013 Tischer A, Cruz MA, Auton M. The linker between the D3 and A1 domains of vWF suppresses A1-GPIbα catch bonds by site-specific binding to the A1 domain. Protein Science : a Publication of the Protein Society. 22: 1049-59. PMID 23775931 DOI: 10.1002/Pro.2294  0.47
2013 Auton M, Bassett GR, Gillard BK, Pownall HJ. Free cholesterol determines reassembled high-density lipoprotein phospholipid phase structure and stability Biochemistry. 52: 4324-4330. PMID 23721456 DOI: 10.1021/Bi4006732  0.305
2012 Auton M, Sowa KE, Behymer M, Cruz MA. N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress Journal of Biological Chemistry. 287: 14579-14585. PMID 22431729 DOI: 10.1074/Jbc.M112.348573  0.489
2011 Auton M, Rösgen J, Sinev M, Holthauzen LM, Bolen DW. Osmolyte effects on protein stability and solubility: a balancing act between backbone and side-chains. Biophysical Chemistry. 159: 90-9. PMID 21683504 DOI: 10.1016/J.Bpc.2011.05.012  0.368
2011 Holthauzen LM, Auton M, Sinev M, Rösgen J. Protein stability in the presence of cosolutes. Methods in Enzymology. 492: 61-125. PMID 21333789 DOI: 10.1016/B978-0-12-381268-1.00015-X  0.351
2010 Auton M, Zhu C, Cruz MA. The mechanism of VWF-mediated platelet GPIbα binding Biophysical Journal. 99: 1192-1201. PMID 20713003 DOI: 10.1016/J.Bpj.2010.06.002  0.492
2010 Auton M, Sowa KE, Smith SM, Sedlák E, Vijayan KV, Cruz MA. Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress. The Journal of Biological Chemistry. 285: 22831-9. PMID 20498367 DOI: 10.1074/Jbc.M110.103358  0.451
2009 Auton M, Sedlák E, Marek J, Wu T, Zhu C, Cruz MA. Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha. Biophysical Journal. 97: 618-27. PMID 19619477 DOI: 10.1016/J.Bpj.2009.05.009  0.452
2008 Auton M, Bolen DW, Rösgen J. Structural thermodynamics of protein preferential solvation: osmolyte solvation of proteins, aminoacids, and peptides. Proteins. 73: 802-13. PMID 18498104 DOI: 10.1002/Prot.22103  0.368
2008 Auton M, Sedlák E, Moake JL, Cruz MA. Thermodynamic Analysis of Von Willebrand Disease Type 2B and 2M Mutations on the Structural Stability of the Von Willebrand Factor A1 Domain. Blood. 112: 3389-3389. DOI: 10.1182/Blood.V112.11.3389.3389  0.487
2007 Auton M, Holthauzen LM, Bolen DW. Anatomy of energetic changes accompanying urea-induced protein denaturation. Proceedings of the National Academy of Sciences of the United States of America. 104: 15317-22. PMID 17878304 DOI: 10.1073/Pnas.0706251104  0.411
2007 Auton M, Bolen DW. Application of the transfer model to understand how naturally occurring osmolytes affect protein stability. Methods in Enzymology. 428: 397-418. PMID 17875431 DOI: 10.1016/S0076-6879(07)28023-1  0.368
2007 Auton M, Cruz MA, Moake J. Conformational Stability and Domain Unfolding of the Von Willebrand Factor A Domains Journal of Molecular Biology. 366: 986-1000. PMID 17187823 DOI: 10.1016/J.Jmb.2006.10.067  0.445
2006 Auton M, Ferreon AC, Bolen DW. Metrics that differentiate the origins of osmolyte effects on protein stability: a test of the surface tension proposal. Journal of Molecular Biology. 361: 983-92. PMID 16889793 DOI: 10.1016/J.Jmb.2006.07.003  0.364
2005 Auton M, Bolen DW. Predicting the energetics of osmolyte-induced protein folding/unfolding. Proceedings of the National Academy of Sciences of the United States of America. 102: 15065-8. PMID 16214887 DOI: 10.1073/Pnas.0507053102  0.382
2004 Auton M, Bolen DW. Additive transfer free energies of the peptide backbone unit that are independent of the model compound and the choice of concentration scale. Biochemistry. 43: 1329-42. PMID 14756570 DOI: 10.1021/Bi035908R  0.333
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