| Year |
Citation |
Score |
| 2023 |
Castillo-Garcia AA, Kappe CO, Cantillo D, Barta K. Aniline derivatives from lignin under mild conditions enabled by electrochemistry. Chemsuschem. e202301374. PMID 37988183 DOI: 10.1002/cssc.202301374 |
0.314 |
|
| 2020 |
von Keutz T, Cantillo D, Kappe CO. Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates. Organic Letters. PMID 32914630 DOI: 10.1021/acs.orglett.0c02725 |
0.418 |
|
| 2020 |
Dallinger D, Gutmann B, Kappe CO. The Concept of Chemical Generators: On-Site On-Demand Production of Hazardous Reagents in Continuous Flow. Accounts of Chemical Research. PMID 32543830 DOI: 10.1021/acs.accounts.0c00199 |
0.341 |
|
| 2020 |
Chen Y, Glotz G, Cantillo D, Kappe CO. Organophotocatalytic N-Demethylation of Oxycodone using Molecular Oxygen. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31898822 DOI: 10.1002/Chem.201905505 |
0.759 |
|
| 2020 |
Mata A, Weigl U, Flögel O, Baur P, Hone CA, Kappe CO. Acyl azide generation and amide bond formation in continuous-flow for the synthesis of peptides Reaction Chemistry & Engineering. 5: 645-650. DOI: 10.1039/d0re00034e |
0.326 |
|
| 2019 |
Ötvös SB, Pericàs MA, Kappe CO. Multigram-scale flow synthesis of the chiral key intermediate of (-)-paroxetine enabled by solvent-free heterogeneous organocatalysis. Chemical Science. 10: 11141-11146. PMID 32206263 DOI: 10.1039/c9sc04752b |
0.388 |
|
| 2019 |
Mata A, Hone CA, Gutmann B, Moens L, Kappe CO. Continuous-Flow Pd-Catalyzed Carbonylation of Aryl Chlorides with Carbon Monoxide at Elevated Temperature and Pressure. Chemcatchem. 11: 997-1001. PMID 31681449 DOI: 10.1002/cctc.201801974 |
0.402 |
|
| 2019 |
Williams JD, Otake Y, Coussanes G, Saridakis I, Maulide N, Kappe CO. Towards a Scalable Synthesis of 2-Oxabicyclo[2.2.0]hex-5-en-3-one Using Flow Photochemistry. Chemphotochem. 3: 229-232. PMID 31423462 DOI: 10.1002/cptc.201900017 |
0.329 |
|
| 2019 |
Chen Y, Cantillo D, Kappe CO. Visible Light-Promoted Beckmann Rearrangements: Separating Sequential Photochemical and Thermal Phenomena in a Continuous Flow Reactor. European Journal of Organic Chemistry. 2019: 2163-2171. PMID 31423105 DOI: 10.1002/Ejoc.201900231 |
0.776 |
|
| 2019 |
Rosso C, Williams JD, Filippini G, Prato M, Kappe CO. Visible-Light-Mediated Iodoperfluoroalkylation of Alkenes in Flow and Its Application to the Synthesis of a Key Fulvestrant Intermediate. Organic Letters. PMID 31247766 DOI: 10.1021/Acs.Orglett.9B01992 |
0.345 |
|
| 2019 |
Aguiar RM, Leão RAC, Mata A, Cantillo D, Kappe CO, Miranda LSM, de Souza ROMA. Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients. Organic & Biomolecular Chemistry. PMID 30693360 DOI: 10.1039/c8ob03088j |
0.349 |
|
| 2019 |
Otake Y, Williams JD, Rincón JA, de Frutos O, Mateos C, Kappe CO. Photochemical benzylic bromination in continuous flow using BrCCl and its application to telescoped p-methoxybenzyl protection. Organic & Biomolecular Chemistry. PMID 30676602 DOI: 10.1039/c9ob00044e |
0.313 |
|
| 2018 |
Hone CA, Kappe CO. The Use of Molecular Oxygen for Liquid Phase Aerobic Oxidations in Continuous Flow. Topics in Current Chemistry (Cham). 377: 2. PMID 30536152 DOI: 10.1007/s41061-018-0226-z |
0.315 |
|
| 2018 |
Hone C, Lopatka P, Munday R, O'Kearney-McMullan A, Kappe CO. Continuous-flow Synthesis of Aryl Aldehydes by Pd-catalyzed Formylation of Aryl Bromides Using Carbon Monoxide and Hydrogen. Chemsuschem. PMID 30300970 DOI: 10.1002/cssc.201802261 |
0.426 |
|
| 2018 |
Rossa TA, Suveges NS, Sá MM, Cantillo D, Kappe CO. Continuous multistep synthesis of 2-(azidomethyl)oxazoles. Beilstein Journal of Organic Chemistry. 14: 506-514. PMID 29520312 DOI: 10.3762/bjoc.14.36 |
0.399 |
|
| 2018 |
Köckinger M, Ciaglia T, Bersier M, Hanselmann P, Gutmann B, Kappe CO. Utilization of fluoroform for difluoromethylation in continuous flow: a concise synthesis of α-difluoromethyl-amino acids Green Chemistry. 20: 108-112. DOI: 10.1039/C7GC02913F |
0.339 |
|
| 2018 |
von Keutz T, Strauss FJ, Cantillo D, Kappe CO. Continuous flow multistep synthesis of α-functionalized esters via lithium enolate intermediates Tetrahedron. 74: 3113-3117. DOI: 10.1016/J.TET.2017.11.063 |
0.336 |
|
| 2018 |
Chen Y, de Frutos O, Mateos C, Rincon JA, Cantillo D, Kappe CO. Continuous Flow Photochemical Benzylic Bromination of a Key Intermediate in the Synthesis of a 2-Oxazolidinone Chemphotochem. 2: 906-912. DOI: 10.1002/CPTC.201800114 |
0.779 |
|
| 2017 |
Cantillo D, Inglesby PA, Boyd A, Kappe CO. Hydrogen sulfide chemistry in continuous flow: Efficient synthesis of 2-oxopropanethioamide Journal of Flow Chemistry. 7: 29-32. DOI: 10.1556/1846.2017.00006 |
0.363 |
|
| 2017 |
Cantillo D, Kappe CO. Halogenation of organic compounds using continuous flow and microreactor technology Reaction Chemistry & Engineering. 2: 7-19. DOI: 10.1039/C6RE00186F |
0.364 |
|
| 2017 |
Chen Y, Hone CA, Gutmann B, Kappe CO. Continuous Flow Synthesis of Carbonylated Heterocycles via Pd-Catalyzed Oxidative Carbonylation Using CO and O2 at Elevated Temperatures and Pressures Organic Process Research & Development. 21: 1080-1087. DOI: 10.1021/Acs.Oprd.7B00217 |
0.768 |
|
| 2017 |
Cantillo D, Wolf B, Goetz R, Kappe CO. Continuous Flow Synthesis of a Key 1,4-Benzoxazinone Intermediate via a Nitration/Hydrogenation/Cyclization Sequence Organic Process Research & Development. 21: 125-132. DOI: 10.1021/ACS.OPRD.6B00409 |
0.352 |
|
| 2017 |
Suveges NS, de Souza ROMA, Gutmann B, Kappe CO. Synthesis of Mepivacaine and Its Analogues by a Continuous-Flow Tandem Hydrogenation/Reductive Amination Strategy European Journal of Organic Chemistry. 2017: 6511-6517. DOI: 10.1002/EJOC.201700824 |
0.372 |
|
| 2017 |
Hone CA, O'Kearney-McMullan A, Munday R, Kappe CO. A Continuous-Flow Process for Palladium-Catalyzed Olefin Cleavage by using Oxygen within the Explosive Regime Chemcatchem. 9: 3298-3302. DOI: 10.1002/cctc.201700671 |
0.361 |
|
| 2017 |
Glotz G, Lebl R, Dallinger D, Kappe CO. Integration of Bromine and Cyanogen Bromide Generators for the Continuous-Flow Synthesis of Cyclic Guanidines Angewandte Chemie. 129: 13974-13977. DOI: 10.1002/ANGE.201708533 |
0.376 |
|
| 2016 |
Monteiro JL, Carneiro PF, Elsner P, Roberge D, Wuts PG, Kurjan K, Gutmann B, Kappe CO. Continuous Flow Homolytic Aromatic Substitution with Electrophilic Radicals - A Fast and Scalable Protocol for Trifluoromethylation. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27775849 DOI: 10.1002/chem.201604579 |
0.39 |
|
| 2016 |
Chen Y, Gutmann B, Kappe CO. Continuous-Flow Electrophilic Amination of Arenes and Schmidt Reaction of Carboxylic Acids Utilizing the Superacidic Trimethylsilyl Azide/Triflic Acid Reagent System. The Journal of Organic Chemistry. PMID 27648816 DOI: 10.1021/Acs.Joc.6B02085 |
0.776 |
|
| 2016 |
Gutmann B, Weigl U, Cox DP, Kappe CO. Batch and Continuous Flow Aerobic Oxidation of 14-Hydroxy Opioids to 1,3-Oxazolidines - A Concise Synthesis of Noroxymorphone. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27172347 DOI: 10.1002/chem.201601902 |
0.379 |
|
| 2016 |
Pieber B, Kappe CO. Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies. Organic Letters. 18: 1076-9. PMID 26902154 DOI: 10.1021/acs.orglett.6b00194 |
0.744 |
|
| 2016 |
Strauss FJ, Cantillo D, Guerra J, Kappe CO. A laboratory-scale continuous flow chlorine generator for organic synthesis Reaction Chemistry & Engineering. 1: 472-476. DOI: 10.1039/C6RE00135A |
0.395 |
|
| 2016 |
Guerra J, Cantillo D, Kappe CO. Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flow Catalysis Science & Technology. 6: 4695-4699. DOI: 10.1039/C6CY00070C |
0.333 |
|
| 2016 |
Gutmann B, Elsner P, Cox DP, Weigl U, Roberge DM, Kappe CO. Toward the Synthesis of Noroxymorphone via Aerobic Palladium-Catalyzed Continuous Flow N-Demethylation Strategies Acs Sustainable Chemistry & Engineering. 4: 6048-6061. DOI: 10.1021/ACSSUSCHEMENG.6B01371 |
0.38 |
|
| 2016 |
Monteiro JL, Pieber B, Correa AC, Kappe CO. ChemInform Abstract: Continuous Synthesis of Hydantoins: Intensifying the Bucherer-Bergs Reaction. Cheminform. 47. DOI: 10.1002/CHIN.201623145 |
0.334 |
|
| 2015 |
Cantillo D, Mateos C, Rincon JA, de Frutos O, Kappe CO. Light-Induced C-H Arylation of (Hetero)arenes by In Situ Generated Diazo Anhydrides. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 12894-8. PMID 26239967 DOI: 10.1002/chem.201502357 |
0.378 |
|
| 2015 |
Gutmann B, Cantillo D, Kappe CO. Continuous-flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients. Angewandte Chemie (International Ed. in English). 54: 6688-728. PMID 25989203 DOI: 10.1002/anie.201409318 |
0.371 |
|
| 2015 |
Salvador CE, Pieber B, Neu PM, Torvisco A, Kleber Z Andrade C, Kappe CO. A sequential Ugi multicomponent/Cu-catalyzed azide-alkyne cycloaddition approach for the continuous flow generation of cyclic peptoids. The Journal of Organic Chemistry. 80: 4590-602. PMID 25842982 DOI: 10.1021/Acs.Joc.5B00445 |
0.757 |
|
| 2015 |
Pieber B, Glasnov T, Kappe CO. Continuous flow reduction of artemisinic acid utilizing multi-injection strategies-closing the gap towards a fully continuous synthesis of antimalarial drugs. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 4368-76. PMID 25655090 DOI: 10.1002/chem.201406439 |
0.732 |
|
| 2015 |
Kappe C, Monteiro J, Pieber B, Corrêa A. Continuous Synthesis of Hydantoins: Intensifying the Bucherer–Bergs Reaction Synlett. 27: 83-87. DOI: 10.1055/S-0035-1560317 |
0.325 |
|
| 2015 |
Greco R, Goessler W, Cantillo D, Kappe CO. Benchmarking Immobilized Di- and Triarylphosphine Palladium Catalysts for Continuous-Flow Cross-Coupling Reactions: Efficiency, Durability, and Metal Leaching Studies Acs Catalysis. 5: 1303-1312. DOI: 10.1021/CS5020089 |
0.318 |
|
| 2015 |
Carneiro PF, Gutmann B, de Souza ROMA, Kappe CO. Process Intensified Flow Synthesis of 1H-4-Substituted Imidazoles: Toward the Continuous Production of Daclatasvir Acs Sustainable Chemistry & Engineering. 3: 3445-3453. DOI: 10.1021/ACSSUSCHEMENG.5B01191 |
0.326 |
|
| 2015 |
Pieber B, Cox DP, Kappe CO. Selective Olefin Reduction in Thebaine Using Hydrazine Hydrate and O2under Intensified Continuous Flow Conditions Organic Process Research & Development. 20: 376-385. DOI: 10.1021/ACS.OPRD.5B00370 |
0.31 |
|
| 2015 |
Gutmann B, Elsner P, O’Kearney-McMullan A, Goundry W, Roberge DM, Kappe CO. Development of a Continuous Flow Sulfoxide Imidation Protocol Using Azide Sources under Superacidic Conditions Organic Process Research & Development. 19: 1062-1067. DOI: 10.1021/Acs.Oprd.5B00217 |
0.414 |
|
| 2014 |
Moghaddam MM, Pieber B, Glasnov T, Kappe CO. Immobilized iron oxide nanoparticles as stable and reusable catalysts for hydrazine-mediated nitro reductions in continuous flow. Chemsuschem. 7: 3122-31. PMID 25209099 DOI: 10.1002/cssc.201402455 |
0.704 |
|
| 2014 |
Gutmann B, Elsner P, Glasnov T, Roberge DM, Kappe CO. Shifting chemical equilibria in flow--efficient decarbonylation driven by annular flow regimes. Angewandte Chemie (International Ed. in English). 53: 11557-61. PMID 25196172 DOI: 10.1002/anie.201407219 |
0.345 |
|
| 2014 |
Cantillo D, de Frutos O, Rincón JA, Mateos C, Kappe CO. A continuous-flow protocol for light-induced benzylic fluorinations. The Journal of Organic Chemistry. 79: 8486-90. PMID 25144336 DOI: 10.1021/jo5016757 |
0.309 |
|
| 2014 |
Hofbauer HF, Schopf FH, Schleifer H, Knittelfelder OL, Pieber B, Rechberger GN, Wolinski H, Gaspar ML, Kappe CO, Stadlmann J, Mechtler K, Zenz A, Lohner K, Tehlivets O, Henry SA, et al. Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids. Developmental Cell. 29: 729-39. PMID 24960695 DOI: 10.1016/J.Devcel.2014.04.025 |
0.665 |
|
| 2014 |
Pinho VD, Gutmann B, Miranda LS, de Souza RO, Kappe CO. Continuous flow synthesis of α-halo ketones: essential building blocks of antiretroviral agents. The Journal of Organic Chemistry. 79: 1555-62. PMID 24471789 DOI: 10.1021/jo402849z |
0.319 |
|
| 2014 |
Cantillo D, de Frutos O, Rincón JA, Mateos C, Kappe CO. Continuous flow α-trifluoromethylation of ketones by metal-free visible light photoredox catalysis. Organic Letters. 16: 896-9. PMID 24432711 DOI: 10.1021/ol403650y |
0.377 |
|
| 2014 |
Cantillo D, de Frutos O, Rincon JA, Mateos C, Kappe CO. A scalable procedure for light-induced benzylic brominations in continuous flow. The Journal of Organic Chemistry. 79: 223-9. PMID 24261546 DOI: 10.1021/jo402409k |
0.403 |
|
| 2014 |
Cantillo D, Damm M, Dallinger D, Bauser M, Berger M, Kappe CO. Sequential Nitration/Hydrogenation Protocol for the Synthesis of Triaminophloroglucinol: Safe Generation and Use of an Explosive Intermediate under Continuous-Flow Conditions Organic Process Research & Development. 18: 1360-1366. DOI: 10.1021/OP5001435 |
0.357 |
|
| 2014 |
Martinez ST, Pinto AC, Glasnov T, Kappe CO. Chemistry of pyrrolizidine alkaloids revisited—semi-synthetic microwave and continuous-flow approaches toward Crotalaria-alkaloids Tetrahedron Letters. 55: 4181-4184. DOI: 10.1016/J.TETLET.2014.05.055 |
0.317 |
|
| 2014 |
de Oliveira Lopes R, de Miranda AS, Reichart B, Glasnov T, Kappe CO, Simon RC, Kroutil W, Miranda LS, Leal IC, de Souza RO. Combined batch and continuous flow procedure to the chemo-enzymatic synthesis of biaryl moiety of Odanacatib Journal of Molecular Catalysis B: Enzymatic. 104: 101-107. DOI: 10.1016/J.MOLCATB.2014.03.017 |
0.355 |
|
| 2013 |
Cantillo D, Kappe CO. Direct preparation of nitriles from carboxylic acids in continuous flow. The Journal of Organic Chemistry. 78: 10567-71. PMID 24066706 DOI: 10.1021/jo401945r |
0.39 |
|
| 2013 |
Pieber B, Martinez ST, Cantillo D, Kappe CO. In situ generation of diimide from hydrazine and oxygen: continuous-flow transfer hydrogenation of olefins. Angewandte Chemie (International Ed. in English). 52: 10241-4. PMID 23946202 DOI: 10.1002/anie.201303528 |
0.71 |
|
| 2013 |
Damm M, Gutmann B, Kappe CO. Continuous-flow synthesis of adipic acid from cyclohexene using hydrogen peroxide in high-temperature explosive regimes. Chemsuschem. 6: 978-82. PMID 23592635 DOI: 10.1002/cssc.201300197 |
0.355 |
|
| 2013 |
Kappe CO, Pieber B, Dallinger D. Microwave effects in organic synthesis: myth or reality? Angewandte Chemie (International Ed. in English). 52: 1088-94. PMID 23225754 DOI: 10.1002/anie.201204103 |
0.691 |
|
| 2013 |
Kappe CO. TheJournal of Flow Chemistryoff to a Good Start and already Highly Cited Journal of Flow Chemistry. 3: 1-2. DOI: 10.1556/JFC-D-13-11101 |
0.326 |
|
| 2013 |
Gutmann B, Gottsponer M, Elsner P, Cantillo D, Roberge DM, Kappe CO. On the Fischer Indole Synthesis of 7-Ethyltryptophol—Mechanistic and Process Intensification Studies under Continuous Flow Conditions Organic Process Research & Development. 17: 294-302. DOI: 10.1021/OP300363S |
0.374 |
|
| 2012 |
Kumar GS, Pieber B, Reddy KR, Kappe CO. Copper-catalyzed formation of C-O bonds by direct α-C-H bond activation of ethers using stoichiometric amounts of peroxide in batch and continuous-flow formats. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 6124-8. PMID 22492535 DOI: 10.1002/chem.201200815 |
0.739 |
|
| 2012 |
Pieber B, Cantillo D, Kappe CO. Direct arylation of benzene with aryl bromides using high-temperature/high-pressure process windows: expanding the scope of C-H activation chemistry. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 5047-55. PMID 22396386 DOI: 10.1002/chem.201103748 |
0.704 |
|
| 2012 |
Gutmann B, Obermayer D, Roduit J, Roberge DM, Kappe CO. Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor Journal of Flow Chemistry. 2: 8-19. DOI: 10.1556/jfchem.2012.00021 |
0.353 |
|
| 2012 |
Glasnov TN, Holbrey JD, Kappe CO, Seddon KR, Yan T. Methylation using dimethylcarbonate catalysed by ionic liquids under continuous flow conditions Green Chemistry. 14: 3071-3076. DOI: 10.1039/C2Gc36226K |
0.385 |
|
| 2012 |
Reichart B, Tekautz G, Kappe CO. Continuous Flow Synthesis ofn-Alkyl Chlorides in a High-Temperature Microreactor Environment Organic Process Research & Development. 17: 152-157. DOI: 10.1021/OP300273U |
0.385 |
|
| 2012 |
Reichart B, Kappe CO. High-temperature continuous flow synthesis of 1,3,4-oxadiazoles via N-acylation of 5-substituted tetrazoles Tetrahedron Letters. 53: 952-955. DOI: 10.1016/J.TETLET.2011.12.043 |
0.363 |
|
| 2012 |
Reichart B, Kappe CO. ChemInform Abstract: High-Temperature Continuous Flow Synthesis of 1,3,4-Oxadiazoles via N-Acylation of 5-Substituted Tetrazoles. Cheminform. 43: no-no. DOI: 10.1002/CHIN.201223139 |
0.37 |
|
| 2011 |
Gutmann B, Roduit JP, Roberge D, Kappe CO. A two-step continuous-flow synthesis of N-(2-aminoethyl)acylamides through ring-opening/hydrogenation of oxazolines. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 13146-50. PMID 22002534 DOI: 10.1002/chem.201102772 |
0.326 |
|
| 2011 |
Glasnov TN, Kappe CO. The microwave-to-flow paradigm: translating high-temperature batch microwave chemistry to scalable continuous-flow processes. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 11956-68. PMID 21932289 DOI: 10.1002/chem.201102065 |
0.321 |
|
| 2011 |
Obermayer D, Glasnov TN, Kappe CO. Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides. The Journal of Organic Chemistry. 76: 6657-69. PMID 21721531 DOI: 10.1021/jo2009824 |
0.379 |
|
| 2011 |
Gutmann B, Glasnov TN, Razzaq T, Goessler W, Roberge DM, Kappe CO. Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor. Beilstein Journal of Organic Chemistry. 7: 503-17. PMID 21647324 DOI: 10.3762/bjoc.7.59 |
0.333 |
|
| 2011 |
Irfan M, Glasnov TN, Kappe CO. Heterogeneous catalytic hydrogenation reactions in continuous-flow reactors. Chemsuschem. 4: 300-16. PMID 21337528 DOI: 10.1002/cssc.201000354 |
0.381 |
|
| 2011 |
Irfan M, Glasnov TN, Kappe CO. Continuous flow ozonolysis in a laboratory scale reactor. Organic Letters. 13: 984-7. PMID 21268661 DOI: 10.1021/ol102984h |
0.324 |
|
| 2011 |
Viviano M, Glasnov TN, Reichart B, Tekautz G, Kappe CO. A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones Organic Process Research & Development. 15: 858-870. DOI: 10.1021/OP2001047 |
0.402 |
|
| 2011 |
Yoshida J, Kim H, Nagaki A, Illg T, Hessel V, Löb P, Schouten JC, Irfan M, Glasnov TN, Kappe CO. Cover Picture: Green and Sustainable Chemical Synthesis Using Flow Microreactors / Continuous Synthesis of tert-Butyl Peroxypivalate using a Single-Channel Microreactor Equipped with Orifices as Emulsification Units / Heterogeneous Catalytic Hydrogenation Chemsuschem. 4: 285-285. DOI: 10.1002/CSSC.201190009 |
0.327 |
|
| 2011 |
Glasnov TN, Kappe CO. ChemInform Abstract: Continuous-Flow Syntheses of Heterocycles Cheminform. 42: no-no. DOI: 10.1002/CHIN.201123218 |
0.361 |
|
| 2010 |
Razzaq T, Kappe CO. Continuous flow organic synthesis under high-temperature/pressure conditions. Chemistry, An Asian Journal. 5: 1274-89. PMID 20411525 DOI: 10.1002/asia.201000010 |
0.375 |
|
| 2010 |
Kappe CO. Journal club. A chemist muses on the technique of microwaving flowing chemical reactions. Nature. 464: 817. PMID 20376111 DOI: 10.1038/464817e |
0.312 |
|
| 2010 |
Kappe CO, Van der Eycken E. Click chemistry under non-classical reaction conditions. Chemical Society Reviews. 39: 1280-90. PMID 20309486 DOI: 10.1039/b901973c |
0.331 |
|
| 2010 |
Damm M, Glasnov TN, Kappe CO. Translating High-Temperature Microwave Chemistry to Scalable Continuous Flow Processes Organic Process Research & Development. 14: 215-224. DOI: 10.1021/OP900297E |
0.324 |
|
| 2010 |
Glasnov TN, Kappe CO. Continuous-flow syntheses of heterocycles Journal of Heterocyclic Chemistry. 48: 11-30. DOI: 10.1002/JHET.568 |
0.355 |
|
| 2010 |
DALVI TS, KAPPE CO, WENTRUP C, KOLLENZ G. ChemInform Abstract: Reaction of Dipivaloylketene Dimer with Oximes and Hydrazines - Synthesis of Tetraoxaadamantanes. Cheminform. 29: no-no. DOI: 10.1002/CHIN.199851177 |
0.314 |
|
| 2010 |
KAPPE CO, FALSONE SF. ChemInform Abstract: Synthesis and Reactions of Biginelli Compounds. Part 12. Polyphosphate Ester Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction. Cheminform. 29: no-no. DOI: 10.1002/CHIN.199843161 |
0.323 |
|
| 2010 |
KAPPE CO, MURPHREE SS, PADWA A. ChemInform Abstract: Synthetic Applications of Furan Diels-Alder Chemistry Cheminform. 29: no-no. DOI: 10.1002/CHIN.199805272 |
0.41 |
|
| 2010 |
KAPPE CO, PADWA A. ChemInform Abstract: A Facile and Efficient Synthesis of Thieno(2,3-c)furans and Furo(3,4-b) indoles via a Pummerer-Induced Cyclization Reaction. Cheminform. 28: no-no. DOI: 10.1002/chin.199704068 |
0.458 |
|
| 2010 |
PADWA A, KAPPE CO, REGER TS. ChemInform Abstract: Tandem Diels-Alder N-Acyliminium Ion Cyclization Reactions. A New Entry into the Erythrinane Skeleton. Cheminform. 27: no-no. DOI: 10.1002/chin.199649241 |
0.388 |
|
| 2010 |
BAKULEV VA, KAPPE CO, PADWA A. ChemInform Abstract: Application of the 1,5-Electrocyclic Reaction in Heterocyclic Synthesis Cheminform. 27: no-no. DOI: 10.1002/chin.199644262 |
0.478 |
|
| 2010 |
PADWA A, COCHRAN JE, KAPPE CO. ChemInform Abstract: Tandem Pummerer-Diels-Alder Reaction Sequence. A Novel Cascade Process for the Preparation of 1-Arylnaphthalene Lignans. Cheminform. 27: no-no. DOI: 10.1002/chin.199639067 |
0.427 |
|
| 2010 |
KAPPE CO, COCHRAN JE, PADWA A. ChemInform Abstract: Generation and Subsequent Cycloaddition Chemistry of α-Amino Isobenzofurans Formed by Cationic Cyclization. Cheminform. 27: no-no. DOI: 10.1002/chin.199615129 |
0.389 |
|
| 2010 |
KAPPE CO, URAY G, ROSCHGER P, LINDNER W, KRATKY C, KELLER W. ChemInform Abstract: Synthesis and Reactions of Biginelli Compounds. Part 5. Facile Preparation and Resolution of a Stable 5-Dihydropyrimidinecarboxylic Acid. Cheminform. 23: no-no. DOI: 10.1002/chin.199242183 |
0.307 |
|
| 2010 |
Glasnov TN, Kappe CO. Toward a Continuous-Flow Synthesis of Boscalid® Advanced Synthesis & Catalysis. 352: 3089-3097. DOI: 10.1002/ADSC.201000646 |
0.379 |
|
| 2010 |
Fuchs M, Goessler W, Pilger C, Kappe CO. Mechanistic Insights into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions using Continuous Flow Conditions Advanced Synthesis & Catalysis. 352: 323-328. DOI: 10.1002/ADSC.200900726 |
0.364 |
|
| 2009 |
Razzaq T, Glasnov TN, Kappe CO. ChemInform Abstract: Continuous-Flow Microreactor Chemistry under High-Temperature/Pressure Conditions. Cheminform. 40. DOI: 10.1002/chin.200928025 |
0.301 |
|
| 2008 |
Chebanov VA, Saraev VE, Desenko SM, Chernenko VN, Knyazeva IV, Groth U, Glasnov TN, Kappe CO. Tuning of chemo- and regioselectivities in multicomponent condensations of 5-aminopyrazoles, dimedone, and aldehydes. The Journal of Organic Chemistry. 73: 5110-8. PMID 18512991 DOI: 10.1021/jo800825c |
0.313 |
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| 2007 |
Machetti F, Bucelli I, Indiani G, Kappe CO, Guarna A. Parallel synthesis of an amide library based on the 6,8-dioxa-3-azabicyclo[3.2.1]octane scaffold by direct aminolysis of methyl esters. Journal of Combinatorial Chemistry. 9: 454-61. PMID 17411098 DOI: 10.1021/CC060120O |
0.335 |
|
| 2007 |
Pisani L, Prokopcová H, Kremsner JM, Kappe CO. 5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques. Journal of Combinatorial Chemistry. 9: 415-21. PMID 17341121 DOI: 10.1021/CC0700041 |
0.339 |
|
| 2007 |
Glasnov TN, Kappe CO. Microwave-Assisted Synthesis under Continuous-Flow Conditions Macromolecular Rapid Communications. 28: 395-410. DOI: 10.1002/MARC.200600665 |
0.376 |
|
| 2006 |
Chebanov VA, Muravyova EA, Desenko SM, Musatov VI, Knyazeva IV, Shishkina SV, Shishkin OV, Kappe CO. Microwave-assisted three-component synthesis of 7-aryl-2-alkylthio-4,7-dihydro-1,2,4-triazolo[1,5-a]-pyrimidine-6-carboxamides and their selective reduction. Journal of Combinatorial Chemistry. 8: 427-34. PMID 16677013 DOI: 10.1021/CC060021A |
0.338 |
|
| 2006 |
Wannberg J, Dallinger D, Kappe CO, Larhed M. Microwave-enhanced and metal-catalyzed functionalizations of the 4-aryl-dihydropyrimidone template. Journal of Combinatorial Chemistry. 7: 574-83. PMID 16004501 DOI: 10.1021/CC049816C |
0.318 |
|
| 2006 |
Glasnov TN, Vugts DJ, Koningstein MM, Desai B, Fabian WMF, Orru RVA, Kappe CO. Microwave-assisted Dimroth rearrangement of thiazines to dihydropyrimidinethiones: Synthetic and mechanistic aspects Qsar and Combinatorial Science. 25: 509-518. DOI: 10.1002/Qsar.200540210 |
0.343 |
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| 2005 |
Glasnov TN, Stadlbauer W, Kappe CO. Microwave-assisted multistep synthesis of functionalized 4-arylquinolin-2(1H)-ones using palladium-catalyzed cross-coupling chemistry. The Journal of Organic Chemistry. 70: 3864-70. PMID 15876072 DOI: 10.1021/JO0502549 |
0.303 |
|
| 2005 |
Khanetskyy B, Dallinger D, Kappe CO. Combining Biginelli multicomponent and click chemistry: generation of 6-(1,2,3-triazol-1-yl)-dihydropyrimidone libraries. Journal of Combinatorial Chemistry. 6: 884-92. PMID 15530114 DOI: 10.1021/CC0498938 |
0.307 |
|
| 2005 |
Strohmeier GA, Haas W, Kappe CO. Synthesis of functionalized 1,3-thiazine libraries combining solid-phase synthesis and post-cleavage modification methods. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 2919-26. PMID 15214073 DOI: 10.1002/CHEM.200305658 |
0.318 |
|
| 2003 |
Kaval N, Bisztray K, Dehaen W, Kappe CO, Van Der Eycken E. Microwave-enhanced transition metal-catalyzed decoration of 2(1H)-pyrazinone scaffolds Molecular Diversity. 7: 125-133. PMID 14870841 DOI: 10.1023/B:MODI.0000006807.43408.d5 |
0.304 |
|
| 2003 |
Stadler A, Yousefi BH, Dallinger D, Walla P, Van Der Eycken E, Kaval N, Kappe CO. Scalability of microwave-assisted organic synthesis. From single-mode to multimode parallel batch reactors Organic Process Research and Development. 7: 707-716. DOI: 10.1021/op034075+ |
0.32 |
|
| 2002 |
Stadler A, Kappe CO. Automated library generation using sequential microwave-assisted chemistry. Application toward the Biginelli multicomponent condensation. Journal of Combinatorial Chemistry. 3: 624-30. PMID 11703160 DOI: 10.1021/CC010044J |
0.314 |
|
| 2001 |
Kappe CO. Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog. Accounts of Chemical Research. 33: 879-88. PMID 11123887 DOI: 10.1021/AR000048H |
0.301 |
|
| 2000 |
Padwa A, Snyder JP, Curtis EA, Sheehan SM, Worsencroft KJ, Kappe CO. Rhodium(II)-catalyzed equilibration of push-pull carbonyl and ammonium ylides. A computationally based understanding of the reaction pathway Journal of the American Chemical Society. 122: 8155-8167. DOI: 10.1021/Ja001088J |
0.464 |
|
| 1998 |
Kappe CO, Falsone SF. Polyphosphate Ester-Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction Synlett. 1998: 718-720. DOI: 10.1055/S-1998-1764 |
0.313 |
|
| 1997 |
Padwa A, Kappe CO, Cochran JE, Snyder JP. Studies Dealing with the Cycloaddition/Ring Opening/Elimination Sequence of 2-Amino-Substituted Isobenzofurans. The Journal of Organic Chemistry. 62: 2786-2797. PMID 11671641 DOI: 10.1021/jo962358c |
0.449 |
|
| 1996 |
Kappe CO, Padwa A. A Facile and Efficient Synthesis of Thieno[2,3-c]furans and Furo[3,4-b]indoles via a Pummerer-Induced Cyclization Reaction. The Journal of Organic Chemistry. 61: 6166-6174. PMID 11667451 DOI: 10.1021/jo9607929 |
0.51 |
|
| 1996 |
Padwa A, Cochran JE, Kappe CO. Tandem Pummerer-Diels-Alder Reaction Sequence. A Novel Cascade Process for the Preparation of 1-Arylnaphthalene Lignans. The Journal of Organic Chemistry. 61: 3706-3714. PMID 11667219 DOI: 10.1021/jo960295s |
0.452 |
|
| 1995 |
Kappe CO, Cochran JE, Padwa A. Generation and Subsequent Cycloaddition Chemistry of α-Amino Isobenzofurans Formed by Cationic Cyclization Tetrahedron Letters. 36: 9285-9288. DOI: 10.1016/0040-4039(95)02013-F |
0.407 |
|
| 1989 |
Kappe CO, Roschger P. Synthesis and reactions of “biginelli-compounds”. Part I Journal of Heterocyclic Chemistry. 26: 55-64. DOI: 10.1002/jhet.5570260112 |
0.306 |
|
| 1989 |
KAPPE CO, ROSCHGER P. ChemInform Abstract: Synthesis and Reactions of “Biginelli-Compounds”. Part 1. Cheminform. 20. DOI: 10.1002/chin.198934221 |
0.316 |
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