Ralph F. Hirschmann, Ph.D.
Affiliations: | 1950-1987 | Chemistry | Merck, Semoy, Centre-Val de Loire, France |
| 1988-2009 | Chemistry | University of Pennsylvania, Philadelphia, PA, United States |
Area:
organic, medicinal and bioorganic chemistryWebsite:
https://www.sas.upenn.edu/news/death-renowned-penn-chemist-ralph-f-hirschmann-1922-2009Google:
"Ralph F. Hirschmann"Bio:
(1922 - 2009)
http://www.nasonline.org/member-directory/deceased-members/30580.html
http://www.acsmedchem.org/hirschmann.html
http://articles.chicagotribune.com/2009-07-26/news/0907240460_1_amino-enzyme-molecules
http://en.wikipedia.org/wiki/Ralph_F._Hirschmann
http://www.chem.umn.edu/groups/baranygp/puzzles/Hirschmann%20Reflections%202007.pdf
Mean distance: 7.78 | S | N | B | C | P |
Parents
Sign in to add mentor| William Summer Johnson | grad student | 1950 | UW Madison | |
| (A new synthesis of the 6-methoxy-17-equilenones : some related stereochemical considerations, synthesis of 5-substituted-1-methyl-2-vinyl-1-cyclohexenes) | ||||
Children
Sign in to add trainee| John Hynes | grad student | ||
| David A Favor | grad student | 1993-1999 | |
| Josephine Liu | grad student | 2000 | Penn |
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Publications
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| Smith AB, Charnley AK, Hirschmann R. (2011) Pyrrolinone-based peptidomimetics. "Let the enzyme or receptor be the judge". Accounts of Chemical Research. 44: 180-93 |
| Smith AB, Xiong H, Charnley AK, et al. (2010) Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 2. Macrocyclic hexapyrrolinones. Organic Letters. 12: 2994-7 |
| Smith AB, Wang W, Charnley AK, et al. (2010) Design, synthesis, and structural analysis of D,L-mixed polypyrrolinones. 1. From nonpeptide peptidomimetics to nanotubes. Organic Letters. 12: 2990-3 |
| SMITH ABI, BENOWITZ AB, FAVOR DA, et al. (2010) ChemInform Abstract: A Second-Generation Synthesis of Scalemic 3,5,5-Trisubstituted Pyrrolin-4-ones: Incorporation of Functionalized Amino Acid Side- Chains. Cheminform. 28: no-no |
| Mowery BP, Prasad V, Kenesky CS, et al. (2006) Catechol: A minimal scaffold for non-peptide peptidomimetics of the i + 1 and i + 2 positions of the beta-turn of somatostatin. Organic Letters. 8: 4397-400 |
| Neelamkavil S, Arison B, Birzin E, et al. (2005) Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol. Journal of Medicinal Chemistry. 48: 4025-30 |
| Angeles AR, Neagu I, Birzin ET, et al. (2005) Synthesis and binding affinities of novel SRIF-mimicking beta-D-glucosides satisfying the requirement for a pi-cloud at C1. Organic Letters. 7: 1121-4 |
| Neelamkavil S, Mowery BP, Thornton ER, et al. (2005) A practical synthesis of Nalpha-Fmoc-L-pyrazinylalanine via Schöllkopf's chiral auxiliary. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 139-42 |
| Smith AB, Charnley AK, Mesaros EF, et al. (2005) Design, synthesis, and binding affinities of pyrrolinone-based somatostatin mimetics. Organic Letters. 7: 399-402 |
| Abrous L, Jokiel PA, Friedrich SR, et al. (2004) Novel chimeric scaffolds to extend the exploration of receptor space: hybrid beta-D-glucose-benzoheterodiazepine structures for broad screening. Effect of amide alkylation on the course of cyclization reactions. The Journal of Organic Chemistry. 69: 280-302 |