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Alexandra M. Ortiz, Ph.D. - Publications

Affiliations: 
2012 Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Immunology
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ortiz AM, Castello Casta F, Rahmberg A, Markowitz TE, Brooks K, Simpson J, Brenchley JM. 2-Hydroxypropyl-β-Cyclodextrin Treatment Induces Modest Immune Activation in Healthy Rhesus Macaques. Journal of Virology. e0060023. PMID 37338342 DOI: 10.1128/jvi.00600-23  0.422
2022 Simpson J, Starke CE, Ortiz AM, Ransier A, Darko S, Douek DC, Brenchley JM. Multiple modes of antigen exposure induce clonotypically diverse epitope-specific CD8+ T cells across multiple tissues in nonhuman primates. Plos Pathogens. 18: e1010611. PMID 35797339 DOI: 10.1371/journal.ppat.1010611  0.45
2022 Ortiz AM, Simpson J, Langner CA, Baker PJ, Aguilar C, Brooks K, Flynn JK, Vinton CL, Rahmberg AR, Hickman HD, Brenchley JM. Butyrate administration is not sufficient to improve immune reconstitution in antiretroviral-treated SIV-infected macaques. Scientific Reports. 12: 7491. PMID 35523797 DOI: 10.1038/s41598-022-11122-x  0.433
2021 Bochart RM, Busman-Sahay K, Bondoc S, Morrow DW, Ortiz AM, Fennessey CM, Fischer MB, Shiel O, Swanson T, Shriver-Munsch CM, Crank HB, Armantrout KM, Barber-Axthelm AM, Langner C, Moats CR, et al. Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques. Plos Pathogens. 17: e1009565. PMID 33970966 DOI: 10.1371/journal.ppat.1009565  0.464
2021 Flynn JK, Langner CA, Karmele EP, Baker PJ, Pei L, Gorfu EG, Bochart RM, Santiana M, Smelkinson MG, Nutman TB, Altan-Bonnet N, Bosinger SE, Kelsall BL, Brenchley JM, Ortiz AM. Luminal microvesicles uniquely influence translocating bacteria after SIV infection. Mucosal Immunology. PMID 33731830 DOI: 10.1038/s41385-021-00393-8  0.355
2020 Sortino O, Phanuphak N, Schuetz A, Ortiz AM, Chomchey N, Belkaid Y, Davis J, Mystakelis HA, Quiñones M, Deleage C, Ingram B, Rerknimitr R, Pinyakorn S, Rupert A, Robb ML, et al. Impact of Acute HIV Infection and Early Antiretroviral Therapy on the Human Gut Microbiome. Open Forum Infectious Diseases. 7: ofz367. PMID 33324725 DOI: 10.1093/Ofid/Ofz367  0.423
2019 Vinton CL, Magaziner SJ, Dowd KA, Robertson SJ, Amaro-Carambot E, Karmele EP, Ortiz AM, Starke CE, Mudd JC, Whitehead SS, Best SM, Pierson TC, Hickman HD, Brenchley JM. Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance. Mbio. 10. PMID 31796542 DOI: 10.1128/Mbio.02790-19  0.486
2019 Starke CE, Vinton CL, Ladell K, McLaren JE, Ortiz AM, Mudd JC, Flynn JK, Lai SH, Wu F, Hirsch VM, Darko S, Douek DC, Price DA, Brenchley JM. SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues. The Journal of Clinical Investigation. PMID 31661461 DOI: 10.1172/Jci129161  0.599
2019 Ortiz AM, Flynn JK, DiNapoli SR, Sortino O, Vujkovic-Cvijin I, Belkaid Y, Sereti I, Brenchley JM. Antiretroviral therapy administration in healthy rhesus macaques is associated with transient shifts in intestinal bacterial diversity and modest immunological perturbations. Journal of Virology. PMID 31270225 DOI: 10.1128/Jvi.00472-19  0.471
2019 Lai S, Starke CE, Flynn JK, Vinton CL, Ortiz AM, Mudd JC, Brenchley JM. SIV infects functionally polarized memory CD4 T cells equivalently . Journal of Virology. PMID 30787150 DOI: 10.1128/Jvi.02163-18  0.621
2018 Ortiz AM, Flynn JK, DiNapoli SR, Vujkovic-Cvijin I, Starke CE, Lai SH, Long ME, Sortino O, Vinton CL, Mudd JC, Johnston L, Busman-Sahay K, Belkaid Y, Estes JD, Brenchley JM. Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques. Nature Medicine. PMID 30061696 DOI: 10.1038/S41591-018-0132-5  0.415
2017 Ortiz AM, Brenchley JM. Microbial translocation: translating simian immunodeficiency virus to HIV. Current Opinion in Hiv and Aids. PMID 29028666 DOI: 10.1097/Coh.0000000000000424  0.422
2017 Vinton CL, Ortiz AM, Calantone N, Mudd JC, Deleage C, Morcock DR, Whitted S, Estes JD, Hirsch VM, Brenchley JM. Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4(+) T Cells in African Green Monkeys. Journal of Immunology (Baltimore, Md. : 1950). PMID 28438898 DOI: 10.4049/Jimmunol.1700136  0.592
2017 DiNapoli SR, Ortiz AM, Wu F, Matsuda K, Twigg HL, Hirsch VM, Knox K, Brenchley JM. Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques. Jci Insight. 2: e91214. PMID 28239657 DOI: 10.1172/Jci.Insight.91214  0.511
2016 Ortiz AM, Carnathan DG, Yu J, Sheehan KM, Kim P, Reynaldi A, Vanderford TH, Klatt NR, Brenchley JM, Davenport MP, Silvestri G. Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys. Plos One. 11: e0156352. PMID 27227993 DOI: 10.1371/Journal.Pone.0156352  0.718
2015 Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y, Apetrei C, Pandrea I, Hecht FM, Pilcher CD, et al. Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. Cell Reports. 13: 1589-97. PMID 26586432 DOI: 10.1016/J.Celrep.2015.10.026  0.498
2015 Fonseca DM, Hand TW, Han SJ, Gerner MY, Glatman Zaretsky A, Byrd AL, Harrison OJ, Ortiz AM, Quinones M, Trinchieri G, Brenchley JM, Brodsky IE, Germain RN, Randolph GJ, Belkaid Y. Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity. Cell. 163: 354-66. PMID 26451485 DOI: 10.1016/J.Cell.2015.08.030  0.387
2015 Ortiz AM, Klase ZA, DiNapoli SR, Vujkovic-Cvijin I, Carmack K, Perkins MR, Calantone N, Vinton CL, Riddick NE, Gallagher J, Klatt NR, McCune JM, Estes JD, Paiardini M, Brenchley JM. IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. Mucosal Immunology. PMID 26286233 DOI: 10.1038/Mi.2015.75  0.555
2015 Ortiz AM, DiNapoli SR, Brenchley JM. Macrophages Are Phenotypically and Functionally Diverse across Tissues in Simian Immunodeficiency Virus-Infected and Uninfected Asian Macaques. Journal of Virology. 89: 5883-94. PMID 25787286 DOI: 10.1128/Jvi.00005-15  0.424
2015 Klase Z, Ortiz A, Deleage C, Mudd JC, Quiñones M, Schwartzman E, Klatt NR, Canary L, Estes JD, Brenchley JM. Dysbiotic bacteria translocate in progressive SIV infection. Mucosal Immunology. 8: 1009-20. PMID 25586559 DOI: 10.1038/Mi.2014.128  0.529
2014 Micci L, Alvarez X, Iriele RI, Ortiz AM, Ryan ES, McGary CS, Deleage C, McAtee BB, He T, Apetrei C, Easley K, Pahwa S, Collman RG, Derdeyn CA, Davenport MP, et al. CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells. Plos Pathogens. 10: e1004467. PMID 25356757 DOI: 10.1371/Journal.Ppat.1004467  0.716
2014 Calantone N, Wu F, Klase Z, Deleage C, Perkins M, Matsuda K, Thompson EA, Ortiz AM, Vinton CL, Ourmanov I, Loré K, Douek DC, Estes JD, Hirsch VM, Brenchley JM. Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells. Immunity. 41: 493-502. PMID 25238099 DOI: 10.1016/J.Immuni.2014.08.014  0.571
2014 Perkins MR, Briant JA, Calantone N, Whitted S, Vinton CL, Klatt NR, Ourmanov I, Ortiz AM, Hirsch VM, Brenchley JM. Homeostatic cytokines induce CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD8αα T cells. Journal of Virology. 88: 10714-24. PMID 24991011 DOI: 10.1128/Jvi.01331-14  0.615
2013 Francella N, Elliott ST, Yi Y, Gwyn SE, Ortiz AM, Li B, Silvestri G, Paiardini M, Derdeyn CA, Collman RG. Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo. Retrovirology. 10: 133. PMID 24219995 DOI: 10.1186/1742-4690-10-133  0.625
2013 Sundaravaradan V, Saleem R, Micci L, Gasper MA, Ortiz AM, Else J, Silvestri G, Paiardini M, Aitchison JD, Sodora DL. Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection. Plos Pathogens. 9: e1003441. PMID 23825945 DOI: 10.1371/Journal.Ppat.1003441  0.681
2013 Francella N, Gwyn SE, Yi Y, Li B, Xiao P, Elliott ST, Ortiz AM, Hoxie JA, Paiardini M, Silvestri G, Derdeyn CA, Collman RG. CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo. Journal of Virology. 87: 9719-32. PMID 23824793 DOI: 10.1128/Jvi.01254-13  0.682
2012 Klatt NR, Estes JD, Sun X, Ortiz AM, Barber JS, Harris LD, Cervasi B, Yokomizo LK, Pan L, Vinton CL, Tabb B, Canary LA, Dang Q, Hirsch VM, Alter G, et al. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunology. 5: 646-57. PMID 22643849 DOI: 10.1038/Mi.2012.38  0.623
2011 Ortiz AM, Klatt NR, Li B, Yi Y, Tabb B, Hao XP, Sternberg L, Lawson B, Carnathan PM, Cramer EM, Engram JC, Little DM, Ryzhova E, Gonzalez-Scarano F, Paiardini M, et al. Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques. The Journal of Clinical Investigation. 121: 4433-45. PMID 22005304 DOI: 10.1172/Jci46023  0.725
2011 Paiardini M, Cervasi B, Reyes-Aviles E, Micci L, Ortiz AM, Chahroudi A, Vinton C, Gordon SN, Bosinger SE, Francella N, Hallberg PL, Cramer E, Schlub T, Chan ML, Riddick NE, et al. Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression. Nature Medicine. 17: 830-6. PMID 21706028 DOI: 10.1038/Nm.2395  0.691
2010 Chan ML, Petravic J, Ortiz AM, Engram J, Paiardini M, Cromer D, Silvestri G, Davenport MP. Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys. Proceedings. Biological Sciences / the Royal Society. 277: 3773-81. PMID 20591864 DOI: 10.1098/Rspb.2010.0972  0.717
2010 Klatt NR, Shudo E, Ortiz AM, Engram JC, Paiardini M, Lawson B, Miller MD, Else J, Pandrea I, Estes JD, Apetrei C, Schmitz JE, Ribeiro RM, Perelson AS, Silvestri G. CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells. Plos Pathogens. 6: e1000747. PMID 20126441 DOI: 10.1371/Journal.Ppat.1000747  0.681
2009 Ortiz AM, Silvestri G. Immunopathogenesis of AIDS. Current Infectious Disease Reports. 11: 239-45. PMID 19366567 DOI: 10.1007/S11908-009-0035-1  0.545
2009 Paiardini M, Hoffman J, Cervasi B, Ortiz AM, Stroud F, Silvestri G, Wilson ME. T-cell phenotypic and functional changes associated with social subordination and gene polymorphisms in the serotonin reuptake transporter in female rhesus monkeys. Brain, Behavior, and Immunity. 23: 286-93. PMID 18992804 DOI: 10.1016/J.Bbi.2008.10.006  0.537
2002 Ortiz AM, Laffon A, Gonzalez-Alvaro I. CD69 expression on lymphocytes and interleukin-15 levels in synovial fluids from different inflammatory arthropathies Rheumatology International. 21: 182-188. PMID 11958434 DOI: 10.1007/s00296-001-0161-z  0.34
2000 Ortiz AM, Garcia-Vicuna R, Sancho D, Laffon A, Sanchez-Madrid F, Gonzalez-Alvaro I. Cyclosporin A inhibits CD69 expression induced on synovial fluid and peripheral blood lymphocytes by interleukin 15 Journal of Rheumatology. 27: 2329-2338. PMID 11036825  0.348
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