| Year |
Citation |
Score |
| 2023 |
Henderson RG, Lefever TW, Heintz MM, Trexler KR, Borghoff SJ, Bonn-Miller MO. Oral toxicity evaluation of cannabidiol. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 176: 113778. PMID 37105391 DOI: 10.1016/j.fct.2023.113778 |
0.312 |
|
| 2020 |
Pham LL, Borghoff S, Thompson C. Comparison of threshold of toxicological concern (TTC) values to oral reference dose (RfD) values. Regulatory Toxicology and Pharmacology : Rtp. 104651. PMID 32229245 DOI: 10.1016/J.Yrtph.2020.104651 |
0.314 |
|
| 2019 |
Wikoff DS, Rager JE, Chappell GA, Fitch S, Haws L, Borghoff SJ. A Framework for Systematic Evaluation and Quantitative Integration of Mechanistic Data in Assessments of Potential Human Carcinogens. Toxicological Sciences : An Official Journal of the Society of Toxicology. 167: 322-335. PMID 30423162 DOI: 10.1093/Toxsci/Kfy279 |
0.323 |
|
| 2018 |
Borghoff SJ, Fitch S, Rager JE, Huggett D. A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine activity of perfluorohexanoic acid. Regulatory Toxicology and Pharmacology : Rtp. 99: 168-181. PMID 30240830 DOI: 10.1016/J.Yrtph.2018.09.001 |
0.34 |
|
| 2018 |
Klaren WD, Ring C, Harris MA, Thompson CM, Borghoff S, Sipes NS, Hsieh JH, Auerbach SS, Rager JE. Identifying Attributes that Influence In Vitro-to-In Vivo Concordance by Comparing In Vitro Tox21 Bioactivity versus In Vivo DrugMatrix Transcriptomic Responses across 130 Chemicals. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30202884 DOI: 10.1093/Toxsci/Kfy220 |
0.41 |
|
| 2018 |
Thompson CM, Suh M, Chappell G, Borghoff S, Ellis-Hutchings R, Wiench K, Finch L, Proctor DM. Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regulatory Toxicology and Pharmacology : Rtp. PMID 29738809 DOI: 10.1016/J.Yrtph.2018.05.006 |
0.404 |
|
| 2018 |
Suh M, Proctor D, Chappell G, Rager J, Thompson C, Borghoff S, Finch L, Ellis-Hutchings R, Wiench K. A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates. Toxicology. PMID 29689363 DOI: 10.1016/J.Tox.2018.04.006 |
0.388 |
|
| 2018 |
Proctor DM, Suh M, Chappell G, Borghoff SJ, Thompson CM, Wiench K, Finch L, Ellis-Hutchings R. An Adverse Outcome Pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regulatory Toxicology and Pharmacology : Rtp. PMID 29684431 DOI: 10.1016/J.Yrtph.2018.04.016 |
0.317 |
|
| 2016 |
Borghoff SJ, Ring C, Banton MI, Leavens TL. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to α2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes. Journal of Applied Toxicology : Jat. PMID 27885692 DOI: 10.1002/Jat.3412 |
0.524 |
|
| 2016 |
Hughes BJ, Thomas J, Lynch AM, Borghoff SJ, Green S, Mensing T, Sarang SS, LeBaron MJ. Methyl isobutyl ketone-induced hepatocellular carcinogenesis in B6C3F1 mice: A constitutive androstane receptor (Car) -mediated mode of action. Regulatory Toxicology and Pharmacology : Rtp. PMID 27664318 DOI: 10.1016/J.Yrtph.2016.09.024 |
0.369 |
|
| 2016 |
Wikoff DS, Rager JE, Haws LC, Borghoff SJ. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework Regulatory Toxicology and Pharmacology. 77: 143-159. DOI: 10.1016/J.Yrtph.2016.01.018 |
0.455 |
|
| 2016 |
Borghoff SJ, Wikoff D, Harvey S, Haws L. Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats Toxicology Reports. 3: 190-201. DOI: 10.1016/j.toxrep.2016.01.007 |
0.321 |
|
| 2015 |
Wikoff D, Thompson C, Perry C, White M, Borghoff S, Fitzgerald L, Haws LC. Development of toxicity values and exposure estimates for tetrabromobisphenol A: application in a margin of exposure assessment. Journal of Applied Toxicology : Jat. PMID 25825072 DOI: 10.1002/Jat.3132 |
0.417 |
|
| 2015 |
Borghoff SJ, Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC. Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding. Toxicology. 333: 1-13. PMID 25797582 DOI: 10.1016/J.Tox.2015.02.003 |
0.428 |
|
| 2014 |
Faber W, Kirkpatrick D, Coder P, Li A, Borghoff S, Banton M. Subchronic, reproductive, and maternal toxicity studies with tertiary butyl acetate (TBAC). Regulatory Toxicology and Pharmacology : Rtp. 68: 332-42. PMID 24486531 DOI: 10.1016/J.Yrtph.2014.01.006 |
0.441 |
|
| 2012 |
Becker RA, Bergfelt DR, Borghoff S, Davis JP, Hamby BT, O'Connor JC, Kaplan AM, Sloan CS, Tyl RW, Wade M, Marty MS. Interlaboratory study comparison of the 15-day intact adult male rat screening assay: evaluation of an antithyroid chemical and a negative control chemical. Birth Defects Research. Part B, Developmental and Reproductive Toxicology. 95: 63-78. PMID 22127959 DOI: 10.1002/Bdrb.20343 |
0.378 |
|
| 2010 |
Borghoff SJ, Parkinson H, Leavens TL. Physiologically based pharmacokinetic rat model for methyl tertiary-butyl ether; comparison of selected dose metrics following various MTBE exposure scenarios used for toxicity and carcinogenicity evaluation. Toxicology. 275: 79-91. PMID 20561556 DOI: 10.1016/j.tox.2010.06.003 |
0.434 |
|
| 2009 |
Borghoff SJ, Hard GC, Berdasco NM, Gingell R, Green SM, Gulledge W. Methyl isobutyl ketone (MIBK) induction of alpha2u-globulin nephropathy in male, but not female rats. Toxicology. 258: 131-8. PMID 19428932 DOI: 10.1016/J.Tox.2009.01.018 |
0.377 |
|
| 2009 |
Leavens TL, Borghoff SJ. Physiologically based pharmacokinetic model of methyl tertiary butyl ether and tertiary butyl alcohol dosimetry in male rats based on binding to alpha2u-globulin. Toxicological Sciences : An Official Journal of the Society of Toxicology. 109: 321-35. PMID 19270017 DOI: 10.1093/Toxsci/Kfp049 |
0.535 |
|
| 2009 |
Clewell RA, Kremer JJ, Williams CC, Campbell JL, Sochaski MA, Andersen ME, Borghoff SJ. Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats. Toxicology. 255: 80-90. PMID 19010379 DOI: 10.1016/J.Tox.2008.10.010 |
0.418 |
|
| 2008 |
Clewell RA, Kremer JJ, Williams CC, Campbell JL, Andersen ME, Borghoff SJ. Tissue exposures to free and glucuronidated monobutylyphthalate in the pregnant and fetal rat following exposure to di-n-butylphthalate: evaluation with a PBPK model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 103: 241-59. PMID 18344531 DOI: 10.1093/Toxsci/Kfn054 |
0.528 |
|
| 2007 |
Liao KH, Tan YM, Conolly RB, Borghoff SJ, Gargas ML, Andersen ME, Clewell HJ. Bayesian estimation of pharmacokinetic and pharmacodynamic parameters in a mode-of-action-based cancer risk assessment for chloroform. Risk Analysis : An Official Publication of the Society For Risk Analysis. 27: 1535-51. PMID 18093051 DOI: 10.1111/J.1539-6924.2007.00987.X |
0.505 |
|
| 2007 |
Ferguson LJ, Lebetkin EH, Lih FB, Tomer KB, Parkinson HD, Borghoff SJ, Burka LT. 14C-labeled pulegone and metabolites binding to alpha2u-globulin in kidneys of male F-344 rats. Journal of Toxicology and Environmental Health. Part A. 70: 1416-23. PMID 17687727 DOI: 10.1080/15287390701382720 |
0.397 |
|
| 2007 |
Gaido KW, Hensley JB, Liu D, Wallace DG, Borghoff S, Johnson KJ, Hall SJ, Boekelheide K. Fetal mouse phthalate exposure shows that Gonocyte multinucleation is not associated with decreased testicular testosterone. Toxicological Sciences : An Official Journal of the Society of Toxicology. 97: 491-503. PMID 17361019 DOI: 10.1093/Toxsci/Kfm049 |
0.44 |
|
| 2007 |
Cruzan G, Borghoff SJ, de Peyster A, Hard GC, McClain M, McGregor DB, Thomas MG. Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents. Regulatory Toxicology and Pharmacology : Rtp. 47: 156-65. PMID 17084497 DOI: 10.1016/J.Yrtph.2006.09.003 |
0.406 |
|
| 2006 |
Schlosser PM, Borghoff SJ, Coldham NG, David JA, Ghosh SK. Physiologically-based pharmacokinetic modeling of genistein in rats, Part I: Model development. Risk Analysis : An Official Publication of the Society For Risk Analysis. 26: 483-500. PMID 16573635 DOI: 10.1111/J.1539-6924.2006.00743.X |
0.4 |
|
| 2006 |
Soucy NV, Parkinson HD, Sochaski MA, Borghoff SJ. Kinetics of genistein and its conjugated metabolites in pregnant Sprague-Dawley rats following single and repeated genistein administration. Toxicological Sciences : An Official Journal of the Society of Toxicology. 90: 230-40. PMID 16352619 DOI: 10.1093/Toxsci/Kfj077 |
0.433 |
|
| 2005 |
Kremer JJ, Williams CC, Parkinson HD, Borghoff SJ. Pharmacokinetics of monobutylphthalate, the active metabolite of di-n-butylphthalate, in pregnant rats. Toxicology Letters. 159: 144-53. PMID 15994034 DOI: 10.1016/J.Toxlet.2005.05.006 |
0.385 |
|
| 2003 |
Bauer AK, Faiola B, Abernethy DJ, Marchan R, Pluta LJ, Wong VA, Gonzalez FJ, Butterworth BE, Borghoff SJ, Everitt JI, Recio L. Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 72: 201-9. PMID 12655032 DOI: 10.1093/Toxsci/Kfg024 |
0.335 |
|
| 2001 |
Williams TM, Borghoff SJ. Characterization of tert-Butyl alcohol binding to α2u-globulin in F-344 rats Toxicological Sciences. 62: 228-235. PMID 11452135 DOI: 10.1093/toxsci/62.2.228 |
0.347 |
|
| 2001 |
Licata AC, Dekant W, Smith CE, Borghoff SJ. A physiologically based pharmacokinetic model for methyl tert-butyl ether in humans: implementing sensitivity and variability analyses. Toxicological Sciences : An Official Journal of the Society of Toxicology. 62: 191-204. PMID 11452131 DOI: 10.1093/Toxsci/62.2.191 |
0.463 |
|
| 2001 |
Borghoff SJ, Prescott JS, Janszen DB, Wong BA, Everitt JI. α2u-Globulin nephropathy, renal cell proliferation, and dosimetry of inhaled tert-butyl alcohol in male and female F-344 rats Toxicological Sciences. 61: 176-186. PMID 11294988 DOI: 10.1093/Toxsci/61.1.176 |
0.394 |
|
| 2000 |
Williams TM, Borghoff SJ. Induction of testosterone biotransformation enzymes following oral administration of methyl tert-butyl ether to male sprague-dawley rats Toxicological Sciences. 57: 147-155. PMID 10966521 DOI: 10.1093/Toxsci/57.1.147 |
0.407 |
|
| 2000 |
Williams TM, Cattley RC, Borghoff SJ. Alterations in endocrine responses in male Sprague-Dawley rats following oral administration of methyl tert-butyl ether Toxicological Sciences. 54: 168-176. PMID 10746943 DOI: 10.1093/Toxsci/54.1.168 |
0.411 |
|
| 1999 |
Collins AS, Sumner SCJ, Borghoff SJ, Medinsky MA. A physiological model for tert-amyl methyl ether and tert-amyl alcohol: Hypothesis testing of model structures Toxicological Sciences. 49: 15-28. PMID 10367338 DOI: 10.1093/Toxsci/49.1.15 |
0.539 |
|
| 1999 |
Prescott-Mathews JS, Poet TS, Borghoff SJ. Evaluation of the in vivo interaction of methyl tert-butyl ether with α2u-globulin in male F-344 rats Toxicology and Applied Pharmacology. 157: 60-67. PMID 10329508 DOI: 10.1006/Taap.1999.8661 |
0.395 |
|
| 1997 |
Poet TS, Valentine JL, Borghoff SJ. Pharmacokinetics of tertiary butyl alcohol in male and female Fischer 344 rats Toxicology Letters. 92: 179-186. PMID 9334828 DOI: 10.1016/S0378-4274(97)00056-8 |
0.359 |
|
| 1997 |
Poet TS, Borghoff SJ. In vitro uptake of methyl tert-butyl ether in male rat kidney: Use of a two-compartment model to describe protein interactions Toxicology and Applied Pharmacology. 145: 340-348. PMID 9266807 DOI: 10.1006/Taap.1997.8193 |
0.421 |
|
| 1997 |
Dix KJ, Kedderis GL, Borghoff SJ. Vehicle-dependent oral absorption and target tissue dosimetry of cl chloroform in male rats and female mice Toxicology Letters. 91: 197-209. PMID 9217240 DOI: 10.1016/S0378-4274(97)00023-4 |
0.405 |
|
| 1997 |
Prescott-Mathews JS, Wolf DC, Wong BA, Borghoff SJ. Methyl tert-butyl ether causes α2u-globulin nephropathy and enhanced renal cell proliferation in male Fischer-344 rats Toxicology and Applied Pharmacology. 143: 301-314. PMID 9144447 DOI: 10.1006/Taap.1996.8085 |
0.403 |
|
| 1996 |
Borghoff SJ, Murphy JE, Medinsky MA. Development of a physiologically based pharmacokinetic model for methyl tertiary-butyl ether and tertiary-butanol in male fischer-344 rats' Fundamental and Applied Toxicology. 30: 264-275. PMID 8812274 DOI: 10.1093/Toxsci/30.2.264 |
0.6 |
|
| 1995 |
Butterworth BE, Templin MV, Borghoff SJ, Conolly RB, Kedderis GL, Wolf DC. The role of regenerative cell proliferation in chloroform-induced cancer. Toxicology Letters. 82: 23-6. PMID 8597058 DOI: 10.1016/0378-4274(95)03543-5 |
0.363 |
|
| 1995 |
Borghoff SJ, Gargas ML, Andersen ME, Conolly RB. Development of a mechanism-based dosimetry model for 2,4,4-trimethyl-2-pentanol-induced α2u-globulin nephropathy in male Fischer 344 rats Fundamental and Applied Toxicology. 25: 124-137. PMID 7541379 DOI: 10.1006/Faat.1995.1046 |
0.461 |
|
| 1995 |
Borghoff SJ, Gargas ML, Andersen ME, Conolly RB. Development of a mechanism-based dosimetry model for 2,4,4-trimethyl-2-pentanol-lnduced α2u-globulin nephropathy in male fischer 344 rats Toxicological Sciences. 25: 124-137. DOI: 10.1093/toxsci/25.1.124 |
0.367 |
|
| 1994 |
Wilke AV, Dorman DC, Borghoff SJ. Use of primary rat proximal tubule fragments for study of α2u-globulin, 2,5-dichlorophenol, and 2,4,4-trimethyl-2-pentanol toxicity In Vitro Toxicology: Journal of Molecular and Cellular Toxicology. 7: 357-368. |
0.388 |
|
| 1993 |
Borghoff SJ, Lagarde WH. Assessment of Binding of 2,4,4-Trimethyl-2-Pentanol to Low-Molecular-Weight Proteins Isolated from Kidneys of Male Rats and Humans Toxicology and Applied Pharmacology. 119: 228-235. PMID 7683150 DOI: 10.1006/Taap.1993.1064 |
0.385 |
|
| 1992 |
Borghoff SJ, Youtsey NL, Swenberg JA. A comparison of European High Test gasoline and PS-6 unleaded gasoline in their abilities to induce alpha 2u-globulin nephropathy and renal cell proliferation. Toxicology Letters. 63: 21-33. PMID 1384172 DOI: 10.1016/0378-4274(92)90104-R |
0.376 |
|
| 1990 |
Borghoff SJ, Short BG, Swenberg JA. Biochemical mechanisms and pathobiology of alpha 2u-globulin nephropathy. Annual Review of Pharmacology and Toxicology. 30: 349-67. PMID 1693054 DOI: 10.1146/Annurev.Pa.30.040190.002025 |
0.353 |
|
| 1989 |
Swenberg JA, Short B, Borghoff S, Strasser J, Charbonneau M. The comparative pathobiology of alpha 2u-globulin nephropathy. Toxicology and Applied Pharmacology. 97: 35-46. PMID 2464861 DOI: 10.1016/0041-008X(89)90053-7 |
0.407 |
|
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