☰

Dan Roden - Publications

Affiliations: 
Vanderbilt University, Nashville, TN 
Area:
Pharmacology, Molecular Biology
Tree Info Grants Similar researchers PubMed Report error

218/500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wei WQ, Guardo C, Gandireddy S, Yan C, Ong H, Kerchberger V, Dickson A, Pfaff E, Master H, Basford M, Tran N, Mancuso S, Syed T, Zhao Z, Feng Q, ... ... Roden D, et al. Genetic and Survey Data Improves Performance of Machine Learning Model for Long COVID. Research Square. PMID 38196610 DOI: 10.21203/rs.3.rs-3749510/v1  0.632
2023 Ma JG, O'Neill MJ, Richardson E, Thomson KL, Ingles J, Muhammad A, Solus JF, Davogustto G, Anderson KC, Benjamin Shoemaker M, Stergachis AB, Floyd BJ, Dunn K, Parikh VN, Chubb H, ... ... Roden DM, et al. Multi-site validation of a functional assay to adjudicate Brugada Syndrome-associated variants. Medrxiv : the Preprint Server For Health Sciences. PMID 38196587 DOI: 10.1101/2023.12.19.23299592  0.678
2023 Yan C, Ong HH, Grabowska ME, Krantz MS, Su WC, Dickson AL, Peterson JF, Feng Q, Roden DM, Stein CM, Kerchberger VE, Malin BA, Wei WQ. Large Language Models Facilitate the Generation of Electronic Health Record Phenotyping Algorithms. Medrxiv : the Preprint Server For Health Sciences. PMID 38196578 DOI: 10.1101/2023.12.19.23300230  0.541
2023 Shuey MM, Stead WW, Aka I, Barnado AL, Bastarache JA, Brokamp E, Campbell M, Carroll RJ, Goldstein JA, Lewis A, Malow BA, Mosley JD, Osterman T, Padovani-Claudio DA, Ramirez A, ... Roden DM, et al. Next-generation phenotyping: introducing phecodeX for enhanced discovery research in medical phenomics. Bioinformatics (Oxford, England). 39. PMID 37930895 DOI: 10.1093/bioinformatics/btad655  0.776
2023 Pershad Y, Mack T, Poisner H, Jakubek YA, Stilp AM, Mitchell BD, Lewis JP, Boerwinkle E, Loos RJ, Chami N, Wang Z, Barnes K, Pankratz N, Fornage M, Redline S, ... ... Roden DM, et al. Determinants of mosaic chromosomal alteration fitness. Medrxiv : the Preprint Server For Health Sciences. PMID 37905118 DOI: 10.1101/2023.10.20.23297280  0.376
2023 O'Neill MJ, Yang T, Laudeman J, Calandranis M, Solus J, Roden DM, Glazer AM. ParSE-seq: A Calibrated Multiplexed Assay to Facilitate the Clinical Classification of Putative Splice-altering Variants. Medrxiv : the Preprint Server For Health Sciences. PMID 37732247 DOI: 10.1101/2023.09.04.23295019  0.655
2023 Deflaux N, Selvaraj MS, Condon HR, Mayo K, Haidermota S, Basford MA, Lunt C, Philippakis AA, Roden DM, Denny JC, Musick A, Collins R, Allen N, Effingham M, Glazer D, et al. Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis. Nature Communications. 14: 5419. PMID 37669985 DOI: 10.1038/s41467-023-41185-x  0.477
2023 Mosley JD, Shelley JP, Dickson AL, Zanussi J, Daniel LL, Zheng NS, Bastarache L, Wei WQ, Shi M, Jarvik GP, Rosenthal EA, Khan A, Sherafati A, Kullo IJ, Walunas TL, ... ... Roden DM, et al. Clinical consequences of a polygenic predisposition to benign lower white blood cell counts. Medrxiv : the Preprint Server For Health Sciences. PMID 37662324 DOI: 10.1101/2023.08.20.23294331  0.633
2023 Mayo KR, Basford MA, Carroll RJ, Dillon M, Fullen H, Leung J, Master H, Rura S, Sulieman L, Kennedy N, Banks E, Bernick D, Gauchan A, Lichtenstein L, Mapes BM, ... ... Roden DM, et al. The Data and Research Center: Creating a Secure, Scalable, and Sustainable Ecosystem for Biomedical Research. Annual Review of Biomedical Data Science. 6: 443-464. PMID 37561600 DOI: 10.1146/annurev-biodatasci-122120-104825  0.765
2023 Wei WQ, Yan C, Grabowska M, Dickson A, Li B, Wen Z, Roden D, Stein C, Embí P, Peterson J, Feng Q, Malin B. Leveraging Generative AI to Prioritize Drug Repurposing Candidates: Validating Identified Candidates for Alzheimer's Disease in Real-World Clinical Datasets. Research Square. PMID 37503019 DOI: 10.21203/rs.3.rs-3125859/v1  0.547
2023 Yan C, Grabowska ME, Dickson AL, Li B, Wen Z, Roden DM, Stein CM, Embí PJ, Peterson JF, Feng Q, Malin BA, Wei WQ. Leveraging Generative AI to Prioritize Drug Repurposing Candidates: Validating Identified Candidates for Alzheimer's Disease in Real-World Clinical Datasets. Medrxiv : the Preprint Server For Health Sciences. PMID 37461512 DOI: 10.1101/2023.07.07.23292388  0.547
2023 Lennon NJ, Kottyan LC, Kachulis C, Abul-Husn N, Arias J, Belbin G, Below JE, Berndt S, Chung W, Cimino JJ, Clayton EW, Connolly JJ, Crosslin D, Dikilitas O, Velez Edwards DR, ... ... Roden D, et al. Selection, optimization, and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse populations. Medrxiv : the Preprint Server For Health Sciences. PMID 37333246 DOI: 10.1101/2023.05.25.23290535  0.557
2023 O'Neill MJ, Chen SN, Rumping L, Johnson R, van Slegtenhorst M, Glazer AM, Yang T, Solus JF, Laudeman J, Mitchell DW, Vanags LR, Kroncke BM, Anderson K, Gao S, Verdonschot JAJ, ... ... Roden DM, et al. Multicenter Clinical and Functional Evidence Reclassifies a Recurrent Non-canonical Filamin C Splice-altering Variant. Heart Rhythm. PMID 37164047 DOI: 10.1016/j.hrthm.2023.05.006  0.656
2023 Muhammad A, Calandranis ME, Li B, Yang T, Blackwell DJ, Harvey ML, Smith JE, Chew AE, Capra JA, Matreyek KA, Fowler DM, Roden DM, Glazer AM. High-throughput functional mapping of variants in an arrhythmia gene, , reveals novel biology. Biorxiv : the Preprint Server For Biology. PMID 37162834 DOI: 10.1101/2023.04.28.538612  0.674
2023 Master H, Annis J, Huang S, Beckman JA, Ratsimbazafy F, Marginean K, Carroll R, Natarajan K, Harrell FE, Roden DM, Harris P, Brittain EL. Author Correction: Association of step counts over time with the risk of chronic disease in the All of Us Research Program. Nature Medicine. PMID 37046000 DOI: 10.1038/s41591-023-02313-8  0.44
2023 Floyd BJ, Weile J, Kannankeril PJ, Glazer AM, Reuter CM, MacRae CA, Ashley EA, Roden DM, Roth FP, Parikh VN. Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest. Circulation. Genomic and Precision Medicine. PMID 36716194 DOI: 10.1161/CIRCGEN.122.003792  0.627
2023 Linder JE, Allworth A, Bland ST, Caraballo PJ, Chisholm RL, Clayton EW, Crosslin DR, Dikilitas O, DiVietro A, Esplin ED, Forman S, Freimuth RR, Gordon AS, Green R, Harden MV, ... ... Roden DM, et al. Returning integrated genomic risk and clinical recommendations: the eMERGE study. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 100006. PMID 36621880 DOI: 10.1016/j.gim.2023.100006  0.529
2022 Hellwege JN, Dorn C, Irvin MR, Limdi NA, Cimino J, Beasley TM, Tsao PS, Damrauer SM, Roden DM, Velez Edwards DR, Wei WQ, Edwards TL. Predictive models for abdominal aortic aneurysms using polygenic scores and PheWAS-derived risk factors. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 28: 425-436. PMID 36540997  0.555
2022 Bersell KR, Yang T, Mosley JD, Glazer AM, Hale AT, Kryshtal DO, Kim K, Steimle JD, Brown JD, Salem JE, Campbell CC, Hong CC, Wells QS, Johnson AN, Short L, ... ... Roden DM, et al. Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization. Circulation. PMID 36524479 DOI: 10.1161/CIRCULATIONAHA.122.062193  0.641
2022 Strayer N, Zhang S, Yao L, Vessels T, Bejan CA, Hsi RS, Shirey-Rice JK, Balko JM, Johnson DB, Phillips EJ, Bick A, Edwards TL, Velez Edwards DR, Pulley JM, Wells QS, ... ... Roden DM, et al. Interactive network-based clustering and investigation of multimorbidity association matrices with associationSubgraphs. Bioinformatics (Oxford, England). PMID 36472455 DOI: 10.1093/bioinformatics/btac780  0.354
2022 Robinson JR, Carroll RJ, Bastarache L, Chen Q, Pirruccello J, Mou Z, Wei WQ, Connolly J, Mentch F, Crane PK, Hebbring SJ, Crosslin DR, Gordon AS, Rosenthal EA, Stanaway IB, ... ... Roden D, et al. Quantifying the phenome-wide disease burden of obesity using electronic health records and genomics. Obesity (Silver Spring, Md.). PMID 36372681 DOI: 10.1002/oby.23561  0.789
2022 Master H, Annis J, Huang S, Beckman JA, Ratsimbazafy F, Marginean K, Carroll R, Natarajan K, Harrell FE, Roden DM, Harris P, Brittain EL. Association of step counts over time with the risk of chronic disease in the All of Us Research Program. Nature Medicine. PMID 36216933 DOI: 10.1038/s41591-022-02012-w  0.469
2022 O'Neill MJ, Wada Y, Hall LD, Mitchell DW, Glazer A, Roden DM. Functional Assays Reclassify Suspected Splice-Altering Variants of Uncertain Significance in Mendelian Channelopathies. Circulation. Genomic and Precision Medicine. 101161CIRCGEN1220037. PMID 36197721 DOI: 10.1161/CIRCGEN.122.003782  0.655
2022 Ramirez AH, Sulieman L, Schlueter DJ, Halvorson A, Qian J, Ratsimbazafy F, Loperena R, Mayo K, Basford M, Deflaux N, Muthuraman KN, Natarajan K, Kho A, Xu H, Wilkins C, ... ... Roden DM, et al. The Research Program: Data quality, utility, and diversity. Patterns (New York, N.Y.). 3: 100570. PMID 36033590 DOI: 10.1016/j.patter.2022.100570  0.787
2022 Yoneda ZT, Anderson KC, Ye F, Quintana JA, O'Neill MJ, Sims RA, Sun L, Glazer AM, Davogustto G, El-Harasis M, Laws JL, Saldivar BN, Crawford DM, Stricker T, Wells Q, ... ... Roden DM, et al. Mortality Among Patients With Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes. Jama Cardiology. PMID 35544069 DOI: 10.1001/jamacardio.2022.0810  0.651
2022 Zeng C, Bastarache LA, Tao R, Venner E, Hebbring S, Andujar JD, Bland ST, Crosslin DR, Pratap S, Cooley A, Pacheco JA, Christensen KD, Perez E, Zawatsky CLB, Witkowski L, ... ... Roden DM, et al. Association of Pathogenic Variants in Hereditary Cancer Genes With Multiple Diseases. Jama Oncology. PMID 35446370 DOI: 10.1001/jamaoncol.2022.0373  0.452
2022 Sulieman L, Cronin RM, Carroll RJ, Natarajan K, Marginean K, Mapes B, Roden D, Harris P, Ramirez A. Comparing medical history data derived from electronic health records and survey answers in the All of Us Research Program. Journal of the American Medical Informatics Association : Jamia. PMID 35396991 DOI: 10.1093/jamia/ocac046  0.762
2022 O'Neill MJ, Muhammad A, Li B, Wada Y, Hall L, Solus JF, Short L, Roden DM, Glazer AM. Dominant negative effects of SCN5A missense variants. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 35305865 DOI: 10.1016/j.gim.2022.02.010  0.66
2022 Gulsevin A, Glazer AM, Shields T, Kroncke BM, Roden DM, Meiler J. Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel Na1.5. International Journal of Molecular Sciences. 23. PMID 35216338 DOI: 10.3390/ijms23042225  0.609
2022 Wu P, Feng Q, Kerchberger VE, Nelson SD, Chen Q, Li B, Edwards TL, Cox NJ, Phillips EJ, Stein CM, Roden DM, Denny JC, Wei WQ. Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension. Nature Communications. 13: 46. PMID 35013250 DOI: 10.1038/s41467-021-27751-1  0.69
2022 Wada Y, Yang T, Shaffer CM, Daniel LL, Glazer AM, Davogustto GE, Lowery BD, Farber-Eger E, Wells QS, Roden DM. Common Ancestry-specific Ion Channel Variants Predispose to Drug-induced Arrhythmias. Circulation. PMID 34994586 DOI: 10.1161/CIRCULATIONAHA.121.054883  0.675
2022 Bastarache L, Denny JC, Roden DM. Phenome-Wide Association Studies. Jama. 327: 75-76. PMID 34982132 DOI: 10.1001/jama.2021.20356  0.463
2021 Papagiannis J, Yang T, Glazer AM, Tisma-Dupanovic S, Avramidis D, Kannankeril PJ, Viskin S, Walsh EP, Roden DM. Incessant atrial and ventricular tachycardias associated with an mutation. Heartrhythm Case Reports. 7: 806-811. PMID 34987964 DOI: 10.1016/j.hrcr.2021.08.013  0.633
2021 Glazer AM, Davogustto GE, Shaffer CM, Vanoye CG, Desai RR, Farber-Eger E, Dikilitas O, Shang N, Pacheco JA, Yang T, Muhammad A, Mosley JD, Van Driest SL, Wells QS, Shaffer LL, ... ... Roden DM, et al. Arrhythmia Variant Associations and Reclassifications in the eMERGE-III Sequencing Study. Circulation. PMID 34930020 DOI: 10.1161/CIRCULATIONAHA.121.055562  0.798
2021 Yoneda ZT, Anderson KC, Quintana JA, O'Neill MJ, Sims RA, Glazer AM, Shaffer CM, Crawford DM, Stricker T, Ye F, Wells Q, Stevenson LW, Michaud GF, Darbar D, Lubitz SA, ... ... Roden DM, et al. Early-Onset Atrial Fibrillation and the Prevalence of Rare Variants in Cardiomyopathy and Arrhythmia Genes. Jama Cardiology. PMID 34495297 DOI: 10.1001/jamacardio.2021.3370  0.64
2021 Wells QS, Bagheri M, Aday AW, Gupta DK, Shaffer CM, Wei WQ, Sarna Vaitinadin N, Khan SS, Greenland P, Wang TJ, Stein CM, Roden DM, Mosley JD. Polygenic Risk Score to Identify Subclinical Coronary Heart Disease Risk in Young Adults. Circulation. Genomic and Precision Medicine. CIRCGEN121003341. PMID 34463132 DOI: 10.1161/CIRCGEN.121.003341  0.503
2021 Kozek K, Wada Y, Sala L, Denjoy I, Egly C, O'Neill MJ, Aiba T, Shimizu W, Makita N, Ishikawa T, Crotti L, Spazzolini C, Kotta MC, Dagradi F, Castelletti S, ... ... Roden DM, et al. Estimating the Post-Test Probability of Long QT Syndrome Diagnosis for Rare Variants. Circulation. Genomic and Precision Medicine. PMID 34309407 DOI: 10.1161/CIRCGEN.120.003289  0.696
2021 Wei WQ, Zhao J, Roden DM, Peterson JF. Machine Learning Challenges in Pharmacogenomic Research. Clinical Pharmacology and Therapeutics. PMID 34217153 DOI: 10.1002/cpt.2329  0.464
2021 Van Driest SL, Abul-Husn NS, Glessner JT, Bastarache L, Nirenberg S, Schildcrout JS, Eswarappa MS, Belbin GM, Shaffer CM, Mentch F, Connolly J, Shi M, Stein CM, Roden DM, Hakonarson H, et al. Association Between a Common, Benign Genotype and Unnecessary Bone Marrow Biopsies Among African American Patients. Jama Internal Medicine. PMID 34180972 DOI: 10.1001/jamainternmed.2021.3108  0.368
2021 Muhammad A, Aka IT, Birdwell KA, Gordon AS, Roden DM, Wei WQ, Mosley JD, Van Driest SL. Genome-wide approach to measure variant-based heritability of drug outcome phenotypes. Clinical Pharmacology and Therapeutics. PMID 34151428 DOI: 10.1002/cpt.2323  0.582
2021 Zheng NS, Stone CA, Jiang L, Shaffer CM, Kerchberger VE, Chung CP, Feng Q, Cox NJ, Stein CM, Roden DM, Denny JC, Phillips EJ, Wei WQ. High-throughput framework for genetic analyses of adverse drug reactions using electronic health records. Plos Genetics. 17: e1009593. PMID 34061827 DOI: 10.1371/journal.pgen.1009593  0.76
2021 Kawai VK, Shi M, Liu G, Feng Q, Wei W, Chung CP, Walunas TL, Gordon AS, Linneman JG, Hebbring SJ, Harley JB, Cox NJ, Roden DM, Stein CM, Mosley JD. Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis. Lupus. 9612033211014952. PMID 33977795 DOI: 10.1177/09612033211014952  0.66
2021 DeLozier S, Bastarache L, Bland S, McPheeters M, Wells Q, Farber-Eger E, Bejan CA, Fabbri D, Rosenbloom T, Roden D, Johnson KB, Wei WQ, Peterson J. Phenotyping coronavirus disease 2019 during a global health pandemic: lessons learned from the characterization of an early cohort. Journal of Biomedical Informatics. 103777. PMID 33838341 DOI: 10.1016/j.jbi.2021.103777  0.578
2021 Wu P, Nelson SD, Zhao J, Stone CA, Feng Q, Chen Q, Larson EA, Li B, Cox NJ, Stein CM, Phillips EJ, Roden DM, Denny JC, Wei WQ. DDIWAS: High-throughput electronic health record-based screening of drug-drug interactions. Journal of the American Medical Informatics Association : Jamia. PMID 33712848 DOI: 10.1093/jamia/ocab019  0.721
2020 Zheng NS, Warner JL, Osterman TJ, Wells QS, Shu XO, Deppen SA, Karp SJ, Dwyer S, Feng Q, Cox NJ, Peterson JF, Michael Stein C, Roden DM, Johnson KB, Wei WQ. A retrospective approach to evaluating potential adverse outcomes associated with delay of procedures for cardiovascular and cancer-related diagnoses in the context of COVID-19. Journal of Biomedical Informatics. 103657. PMID 33309899 DOI: 10.1016/j.jbi.2020.103657  0.78
2020 Streeten EA, See VY, Jeng LBJ, Maloney KA, Lynch M, Glazer AM, Yang T, Roden DM, Pollin TI, Daue M, Ryan KA, Van Hout C, Gosalia N, Gonzaga-Jauregui C, Economides A, et al. and Long QT Syndrome in 1/45 Amish: The Road from Identification to Implementation of Culturally Appropriate Precision Medicine. Circulation. Genomic and Precision Medicine. PMID 33141630 DOI: 10.1161/CIRCGEN.120.003133  0.683
2020 DeLozier S, Speltz P, Brito J, Tang LA, Wang J, Smith JC, Giuse D, Phillips E, Williams K, Strickland T, Davogustto G, Roden D, Denny JC. Real-time clinical note monitoring to detect conditions for rapid follow-up: A case study of clinical trial enrollment in drug-induced torsades de pointes and Stevens-Johnson syndrome. Journal of the American Medical Informatics Association : Jamia. PMID 33120413 DOI: 10.1093/jamia/ocaa213  0.465
2020 Zheng NS, Feng Q, Kerchberger VE, Zhao J, Edwards TL, Cox NJ, Stein CM, Roden DM, Denny JC, Wei WQ. PheMap: a multi-resource knowledge base for high-throughput phenotyping within electronic health records. Journal of the American Medical Informatics Association : Jamia. PMID 32974638 DOI: 10.1093/jamia/ocaa104  0.731
2020 Krebs K, Bovijn J, Zheng N, Lepamets M, Censin JC, Jürgenson T, Särg D, Abner E, Laisk T, Luo Y, Skotte L, Geller F, Feenstra B, Wang W, Auton A, ... ... Roden DM, et al. Genome-wide Study Identifies Association between HLA-B55:01 and Self-Reported Penicillin Allergy. American Journal of Human Genetics. PMID 32888428 DOI: 10.1016/J.Ajhg.2020.08.008  0.588
2020 Kroncke BM, Smith DK, Zuo Y, Glazer AM, Roden DM, Blume JD. A Bayesian method to estimate variant-induced disease penetrance. Plos Genetics. 16: e1008862. PMID 32569262 DOI: 10.1371/Journal.Pgen.1008862  0.69
2020 Glazer AM, Wada Y, Li B, Muhammad A, Kalash OR, O'Neill MJ, Shields T, Hall L, Short L, Blair MA, Kroncke BM, Capra JA, Roden DM. High-Throughput Reclassification of SCN5A Variants. American Journal of Human Genetics. PMID 32533946 DOI: 10.1016/J.Ajhg.2020.05.015  0.679
2020 Kozek KA, Glazer AM, Ng CA, Blackwell D, Egly CL, Vanags LR, Blair M, Mitchell D, Matreyek KA, Fowler DM, Knollmann BC, Vandenberg JI, Roden DM, Kroncke BM. High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel K11.1. Heart Rhythm. PMID 32522694 DOI: 10.1016/J.Hrthm.2020.05.041  0.652
2020 Mosley JD, Levinson RT, Farber-Eger E, Edwards TL, Hellwege JN, Hung AM, Giri A, Shuey MM, Shaffer CM, Shi M, Brittain EL, Chung WK, Kullo IJ, Arruda-Olson AM, Jarvik GP, ... ... Roden DM, et al. The polygenic architecture of left ventricular mass mirrors the clinical epidemiology. Scientific Reports. 10: 7561. PMID 32372017 DOI: 10.1038/S41598-020-64525-Z  0.487
2020 Kawai VK, Shi M, Feng Q, Chung CP, Liu G, Cox NJ, Jarvik GP, Lee MTM, Hebbring SJ, Harley JB, Kaufman KM, Namjou B, Larson E, Gordon AS, Roden DM, et al. Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis - a phenome-wide association study and inverse-variance weighted meta-analysis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 32307929 DOI: 10.1002/Art.41291  0.518
2020 Jerome RN, Joly MM, Kennedy N, Shirey-Rice JK, Roden DM, Bernard GR, Holroyd KJ, Denny JC, Pulley JM. Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use. Drug Safety. PMID 32112228 DOI: 10.1007/S40264-020-00915-6  0.428
2020 Choi L, Beck C, McNeer E, Weeks HL, Williams ML, James NT, Niu X, Abou-Khalil BW, Birdwell KA, Roden DM, Stein CM, Bejan CA, Denny JC, Van Driest SL. Development of a System for Post-marketing Population Pharmacokinetic and Pharmacodynamic Studies using Real-World Data from Electronic Health Records. Clinical Pharmacology and Therapeutics. PMID 31957870 DOI: 10.1002/Cpt.1787  0.429
2020 Glazer AM, Kroncke BM, Matreyek KA, Yang T, Wada Y, Shields T, Salem JE, Fowler DM, Roden DM. Deep Mutational Scan of an Voltage Sensor. Circulation. Genomic and Precision Medicine. PMID 31928070 DOI: 10.1161/CIRCGEN.119.002786  0.665
2020 Davogustto GE, Glazer A, Shaffer CM, Farber-Eger E, Dikilitas O, Ning S, Pacheco J, Mosley J, Van Driest S, Wells Q, Rinke LL, Kalash O, Wada Y, Bland S, Yoneda ZT, ... ... Roden DM, et al. Abstract 14663: High Rate of Arrhythmia Diagnoses Following Return of Pathogenic/likely Pathogenic Variants in an Unselected Population Circulation. 142. DOI: 10.1161/CIRC.142.SUPPL_3.14663  0.673
2019 Bernal CJ, Aka I, Carroll RJ, Coco JR, Lima JJ, Acra SA, Roden DM, Van Driest SL. CYP2C19 Phenotype and Risk of Proton Pump Inhibitor-Associated Infections. Pediatrics. PMID 31699831 DOI: 10.1542/peds.2019-0857  0.445
2019 Schmidt AF, Holmes MV, Preiss D, Swerdlow DI, Denaxas S, Fatemifar G, Faraway R, Finan C, Valentine D, Fairhurst-Hunter Z, Hartwig FP, Horta BL, Hypponen E, Power C, Moldovan M, ... ... Roden DM, et al. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9. Bmc Cardiovascular Disorders. 19: 240. PMID 31664920 DOI: 10.1186/S12872-019-1187-Z  0.475
2019 Bastarache L, Hughey JJ, Goldstein JA, Bastraache JA, Das S, Zaki NC, Zeng C, Tang LA, Roden DM, Denny JC. Improving the phenotype risk score as a scalable approach to identifying patients with Mendelian disease. Journal of the American Medical Informatics Association : Jamia. PMID 31609419 DOI: 10.1093/Jamia/Ocz179  0.715
2019 Robinson JR, Carroll RJ, Bastarache L, Chen Q, Mou Z, Wei WQ, Connolly JJ, Mentch F, Sleiman P, Crane PK, Hebbring SJ, Stanaway IB, Crosslin DR, Gordon AS, Rosenthal EA, ... ... Roden DM, et al. Association of Genetic Risk of Obesity with Postoperative Complications Using Mendelian Randomization. World Journal of Surgery. PMID 31605180 DOI: 10.1007/S00268-019-05202-9  0.772
2019 Shi Y, Graves JA, Garbett SP, Zhou Z, Marathi R, Wang X, Harrell FE, Lasko TA, Denny JC, Roden DM, Peterson JF, Schildcrout JS. A Decision-Theoretic Approach to Panel-Based, Preemptive Genotyping. Mdm Policy & Practice. 4: 2381468319864337. PMID 31453360 DOI: 10.1177/2381468319864337  0.482
2019 Peterson JF, Roden DM, Orlando LA, Ramirez AH, Mensah GA, Williams MS. Building evidence and measuring clinical outcomes for genomic medicine. Lancet (London, England). PMID 31395443 DOI: 10.1016/S0140-6736(19)31278-4  0.56
2019 Manolio TA, Rowley R, Williams MS, Roden D, Ginsburg GS, Bult C, Chisholm RL, Deverka PA, McLeod HL, Mensah GA, Relling MV, Rodriguez LL, Tamburro C, Green ED. Opportunities, resources, and techniques for implementing genomics in clinical care. Lancet (London, England). PMID 31395439 DOI: 10.1016/S0140-6736(19)31140-7  0.349
2019 Salem JE, Yang T, Moslehi JJ, Waintraub X, Gandjbakhch E, Bachelot A, Hidden-Lucet F, Hulot JS, Knollmann BC, Lebrun-Vignes B, Funck-Brentano C, Glazer AM, Roden DM. Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes. Circulation. PMID 31378084 DOI: 10.1161/CIRCULATIONAHA.119.040162  0.631
2019 Edwards TL, Giri A, Hellwege JN, Hartmann KE, Stewart EA, Jeff JM, Bray MJ, Pendergrass SA, Torstenson ES, Keaton JM, Jones SH, Gogoi RP, Kuivaniemi H, Jackson KL, Kho AN, ... ... Roden DM, et al. A -Ethnic Genome-Wide Association Study of Uterine Fibroids. Frontiers in Genetics. 10: 511. PMID 31249589 DOI: 10.3389/Fgene.2019.00511  0.489
2019 Hellwege JN, Stallings S, Torstenson ES, Carroll R, Borthwick KM, Brilliant MH, Crosslin D, Gordon A, Hripcsak G, Jarvik GP, Linneman JG, Devi P, Peissig PL, Sleiman PAM, Hakonarson H, ... ... Roden DM, et al. Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network. Scientific Reports. 9: 6077. PMID 30988330 DOI: 10.1038/S41598-019-42427-Z  0.515
2019 Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM. Genome-wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol. Clinical Pharmacology and Therapeutics. PMID 30924126 DOI: 10.1002/Cpt.1439  0.66
2019 Oshikoya KA, Carroll R, Aka I, Roden DM, Van Driest SL. Adverse Events Associated with Risperidone Use in Pediatric Patients: A Retrospective Biobank Study. Drugs - Real World Outcomes. PMID 30919267 DOI: 10.1007/S40801-019-0151-7  0.432
2019 Unlu G, Gamazon ER, Qi X, Levic DS, Bastarache L, Denny JC, Roden DM, Mayzus I, Breyer M, Zhong X, Konkashbaev AI, Rzhetsky A, Knapik EW, Cox NJ. GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish. American Journal of Human Genetics. PMID 30827500 DOI: 10.1016/J.Ajhg.2019.01.017  0.635
2019 Safarova MS, Satterfield BA, Fan X, Austin EE, Ye Z, Bastarache L, Zheng N, Ritchie MD, Borthwick KM, Williams MS, Larson EB, Scrol A, Jarvik GP, Crosslin DR, Leppig K, ... ... Roden DM, et al. A phenome-wide association study to discover pleiotropic effects of , , and . Npj Genomic Medicine. 4: 3. PMID 30774981 DOI: 10.1038/S41525-019-0078-7  0.745
2019 Ellervik C, Roselli C, Christophersen IE, Alonso A, Pietzner M, Sitlani CM, Trompet S, Arking DE, Geelhoed B, Guo X, Kleber ME, Lin HJ, Lin H, MacFarlane P, Selvin E, ... ... Roden D, et al. Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study. Jama Cardiology. PMID 30673084 DOI: 10.1001/Jamacardio.2018.4635  0.306
2019 Salem JE, Shoemaker MB, Bastarache L, Shaffer CM, Glazer AM, Kroncke B, Wells QS, Shi M, Straub P, Jarvik GP, Larson EB, Velez Edwards DR, Edwards TL, Davis LK, Hakonarson H, ... ... Roden DM, et al. Association of Thyroid Function Genetic Predictors With Atrial Fibrillation: A Phenome-Wide Association Study and Inverse-Variance Weighted Average Meta-analysis. Jama Cardiology. PMID 30673079 DOI: 10.1001/Jamacardio.2018.4615  0.702
2019 Oshikoya KA, Neely KM, Carroll RJ, Aka IT, Maxwell-Horn AC, Roden DM, Van Driest SL. CYP2D6 genotype and adverse events to risperidone in children and adolescents. Pediatric Research. PMID 30661084 DOI: 10.1038/s41390-019-0305-z  0.419
2019 Salem JE, Yang T, Moslehi JJ, Waintraub X, Gandjbakhch E, Bachelot A, Hidden-Lucet F, Hulot JS, Knollmann BC, Lebrun-Vignes B, Funck-Brentano C, Glazer AM, Roden DM. P6590Androgenic effects on ventricular repolarization: a translational study from pharmacovigilance databases to iPSC-cardiomyocytes European Heart Journal. 40. DOI: 10.1093/eurheartj/ehz746.1178  0.644
2018 Robinson JR, Wei WQ, Roden DM, Denny JC. Defining Phenotypes from Clinical Data to Drive Genomic Research. Annual Review of Biomedical Data Science. 1: 69-92. PMID 34109303 DOI: 10.1146/annurev-biodatasci-080917-013335  0.784
2018 Gonsalves SG, Dirksen RT, Sangkuhl K, Pulk R, Alvarellos M, Vo T, Hikino K, Roden D, Klein T, Mark Poler S, Patel S, Caudle KE, Gordon R, Brandom B, Biesecker LG. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR1 or CACNA1S genotypes. Clinical Pharmacology and Therapeutics. PMID 30499100 DOI: 10.1002/Cpt.1319  0.302
2018 Mosley JD, Feng Q, Wells QS, Van Driest SL, Shaffer CM, Edwards TL, Bastarache L, Wei WQ, Davis LK, McCarty CA, Thompson W, Chute CG, Jarvik GP, Gordon AS, Palmer MR, ... ... Roden DM, et al. A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers. Nature Communications. 9: 3522. PMID 30166544 DOI: 10.1038/S41467-018-05624-4  0.582
2018 Feng Q, Wei WQ, Chung CP, Levinson RT, Sundermann AC, Mosley JD, Bastarache L, Ferguson JF, Cox NJ, Roden DM, Denny JC, Linton MF, Edwards DRV, Stein CM. Relationship between very low low-density lipoprotein cholesterol concentrations not due to statin therapy and risk of type 2 diabetes: A US-based cross-sectional observational study using electronic health records. Plos Medicine. 15: e1002642. PMID 30153257 DOI: 10.1371/Journal.Pmed.1002642  0.711
2018 Pacheco JA, Rasmussen LV, Kiefer RC, Campion TR, Speltz P, Carroll RJ, Stallings SC, Mo H, Ahuja M, Jiang G, LaRose ER, Peissig PL, Shang N, Benoit B, Gainer VS, ... ... Roden DM, et al. A case study evaluating the portability of an executable computable phenotype algorithm across multiple institutions and electronic health record environments. Journal of the American Medical Informatics Association : Jamia. PMID 30124903 DOI: 10.1093/Jamia/Ocy101  0.582
2018 Jerome RN, Pulley JM, Roden DM, Shirey-Rice JK, Bastarache LA, Bernard G, Ekstrom L, Lancaster WJ, Denny JC. Reply to Ward and Colleagues' Comment on "Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors". Drug Safety. PMID 30066313 DOI: 10.1007/S40264-018-0701-Z  0.386
2018 Salem JE, Waintraub X, Courtillot C, Shaffer CM, Gandjbakhch E, Maupain C, Moslehi JJ, Badilini F, Haroche J, Gougis P, Fressart V, Glazer AM, Hidden-Lucet F, Touraine P, Lebrun-Vignes B, ... Roden DM, et al. Hypogonadism as a Reversible Cause of Torsades de Pointes in Men. Circulation. 138: 110-113. PMID 29967236 DOI: 10.1161/CIRCULATIONAHA.118.034282  0.593
2018 Choi L, Carroll RJ, Beck C, Mosley JD, Roden DM, Denny JC, Van Driest SL. Evaluating statistical approaches to leverage large clinical datasets for uncovering therapeutic and adverse medication effects. Bioinformatics (Oxford, England). PMID 29912272 DOI: 10.1093/Bioinformatics/Bty306  0.636
2018 Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, ... ... Roden DM, et al. Multi-ethnic genome-wide association study for atrial fibrillation. Nature Genetics. PMID 29892015 DOI: 10.1038/S41588-018-0133-9  0.481
2018 Smith JC, Chen Q, Denny JC, Roden DM, Johnson KB, Miller RA. Evaluation of a Novel System to Enhance Clinicians' Recognition of Preadmission Adverse Drug Reactions. Applied Clinical Informatics. 9: 313-325. PMID 29742757 DOI: 10.1055/S-0038-1646963  0.621
2018 Kroncke BM, Glazer AM, Smith DK, Blume JD, Roden DM. (Na1.5) Variant Functional Perturbation and Clinical Presentation: Variants of a Certain Significance. Circulation. Genomic and Precision Medicine. 11: e002095. PMID 29728395 DOI: 10.1161/CIRCGEN.118.002095  0.674
2018 Grouthier V, Lebrun-Vignes B, Glazer AM, Touraine P, Funck-Brentano C, Pariente A, Courtillot C, Bachelot A, Roden DM, Moslehi JJ, Salem JE. Increased long QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors. Heart (British Cardiac Society). PMID 29720397 DOI: 10.1136/heartjnl-2017-312934  0.62
2018 Roden DM, Glazer AM, Kroncke B. Arrhythmia genetics: Not dark and lite, but fifty shades of grey. Heart Rhythm. PMID 29709575 DOI: 10.1016/J.Hrthm.2018.04.031  0.647
2018 Wei WQ, Li X, Feng Q, Kubo M, Kullo IJ, Peissig PL, Karlson EW, Jarvik GP, Lee MTM, Shang N, Larson EA, Edwards T, Shaffer C, Mosley JD, Maeda S, ... ... Roden DM, et al. Variants are Associated with Residual Cardiovascular Risk in Patients Receiving Statins. Circulation. PMID 29703846 DOI: 10.1161/Circulationaha.117.031356  0.742
2018 Roden DM, Van Driest SL, Wells QS, Mosley JD, Denny JC, Peterson JF. Opportunities and Challenges in Cardiovascular Pharmacogenomics: From Discovery to Implementation. Circulation Research. 122: 1176-1190. PMID 29700066 DOI: 10.1161/Circresaha.117.310965  0.461
2018 Bastarache L, Hughey JJ, Hebbring S, Marlo J, Zhao W, Ho WT, Van Driest SL, McGregor TL, Mosley JD, Wells QS, Temple M, Ramirez AH, Carroll R, Osterman T, Edwards T, ... ... Roden DM, et al. Phenotype risk scores identify patients with unrecognized Mendelian disease patterns. Science (New York, N.Y.). 359: 1233-1239. PMID 29590070 DOI: 10.1126/Science.Aal4043  0.798
2018 Volpi S, Bult C, Chisholm RL, Deverka PA, Ginsburg GS, Jacob HJ, Kasapi M, McLeod HL, Roden DM, Williams MS, Green ED, Lyman Rodriguez L, Aronson S, Cavallari LH, Denny JC, et al. Research directions in the clinical implementation of pharmacogenomics - An Overview of US programs and projects. Clinical Pharmacology and Therapeutics. PMID 29460415 DOI: 10.1002/Cpt.1048  0.46
2018 Goldstein JA, Bastarache LA, Denny JC, Roden DM, Pulley JM, Aronoff DM. Calcium Channel Blockers as Drug Repurposing Candidates for Gestational Diabetes: Mining large scale genomic and electronic health records data to repurpose medications. Pharmacological Research. PMID 29448118 DOI: 10.1016/J.Phrs.2018.02.013  0.713
2018 Roden DM, Van Driest SL, Mosley JD, Wells QS, Robinson JR, Denny JC, Peterson JF. Benefit of pre-emptive pharmacogenetic information on clinical outcome. Clinical Pharmacology and Therapeutics. PMID 29377064 DOI: 10.1002/Cpt.1035  0.701
2018 Robinson JR, Wei W, Roden DM, Denny JC. Defining Phenotypes from Clinical Data to Drive Genomic Research Annual Review of Biomedical Data Science. 1: 69-92. DOI: 10.1146/ANNUREV-BIODATASCI-080917-013335  0.594
2018 Robinson JR, Carroll RJ, Bastarache L, Mou Z, Jackson GP, Roden DM, Denny JC. Association of Obesity with Postoperative Complications Using Phenome-Wide Association Studies and Mendelian Randomization Journal of the American College of Surgeons. 227. DOI: 10.1016/J.Jamcollsurg.2018.07.192  0.568
2018 Phillips EJ, Wei W, Shaffer CM, Feng Q, Stone CA, Stein CM, Roden DM, Denny JC. A High-Throughput Genetic Analysis of Common Drug Allergy Labels Using Data from a Large Biobank Journal of Allergy and Clinical Immunology. 141: AB399. DOI: 10.1016/J.Jaci.2017.12.937  0.646
2018 Parikh S, Chavali N, Glazer A, Shaffer C, Blair M, Roden D, Knollmann B. High-Throughput Investigation of Contractile and Electrophysiological Properties of Optically Stimulated hiPSC-CM Monolayers Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2122  0.625
2017 Jerome RN, Pulley JM, Roden DM, Shirey-Rice JK, Bastarache LA, R Bernard G, B Ekstrom L, Lancaster WJ, Denny JC. Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors. Drug Safety. PMID 29185237 DOI: 10.1007/S40264-017-0616-0  0.412
2017 Denny JC, Van Driest SL, Wei WQ, Roden DM. The influence of big (clinical) data and genomics on precision medicine and drug development. Clinical Pharmacology and Therapeutics. PMID 29171014 DOI: 10.1002/Cpt.951  0.674
2017 Robinson JR, Denny JC, Roden DM, Van Driest SL. Genome-wide and Phenome-wide Approaches to Understand Variable Drug Actions in Electronic Health Records. Clinical and Translational Science. PMID 29148204 DOI: 10.1111/Cts.12522  0.72
2017 Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, ... ... Roden DM, et al. Exome-wide association study of plasma lipids in >300,000 individuals. Nature Genetics. PMID 29083408 DOI: 10.1038/Ng.3977  0.431
2017 Hellwege JN, Jeff JM, Wise LA, Gallagher CS, Wellons M, Hartmann KE, Jones SF, Torstenson ES, Dickinson S, Ruiz-Narváez EA, Rohland N, Allen A, Reich D, Tandon A, Pasaniuc B, ... ... Roden DM, et al. Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans. Human Genetics. PMID 28975356 DOI: 10.1007/S00439-017-1846-Z  0.424
2017 Weng LC, Lunetta KL, Müller-Nurasyid M, Smith AV, Thériault S, Weeke PE, Barnard J, Bis JC, Lyytikäinen LP, Kleber ME, Martinsson A, Lin HJ, Rienstra M, Trompet S, Krijthe BP, ... ... Roden DM, et al. Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium. Scientific Reports. 7: 11303. PMID 28900195 DOI: 10.1038/S41598-017-09396-7  0.596
2017 Hellwege JN, Jeff JM, Wise LA, Gallagher CS, Wellons M, Hartmann KE, Jones SF, Torstenson ES, Dickinson S, Ruiz-Narváez EA, Rohland N, Allen A, Reich D, Tandon A, Pasaniuc B, ... ... Roden DM, et al. A multi-stage genome-wide association study of uterine fibroids in African Americans. Human Genetics. PMID 28836065 DOI: 10.1007/S00439-017-1836-1  0.471
2017 Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, ... ... Roden DM, et al. Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nature Genetics. 49: 1286. PMID 28747752 DOI: 10.1038/ng0817-1286c  0.466
2017 Karnes JH, Shaffer CM, Cronin R, Bastarache L, Gaudieri S, James I, Pavlos R, Steiner H, Mosley JD, Mallal S, Denny JC, Phillips EJ, Roden DM. Influence of human leukocyte antigen (HLA) alleles and killer cell immunoglobulin-like receptors (KIR) types on heparin-induced thrombocytopenia (HIT). Pharmacotherapy. PMID 28688202 DOI: 10.1002/Phar.1983  0.662
2017 Wei WQ, Bastarache LA, Carroll RJ, Marlo JE, Osterman TJ, Gamazon ER, Cox NJ, Roden DM, Denny JC. Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record. Plos One. 12: e0175508. PMID 28686612 DOI: 10.1371/Journal.Pone.0175508  0.787
2017 Wells QS, Veatch OJ, Fessel JP, Joon AY, Levinson RT, Mosley JD, Held EP, Lindsay CS, Shaffer CM, Weeke PE, Glazer AM, Bersell KR, Van Driest SL, Karnes JH, Blair MA, ... ... Roden DM, et al. Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults. Pharmacogenetics and Genomics. PMID 28542097 DOI: 10.1097/Fpc.0000000000000284  0.722
2017 Karnes JH, Bastarache L, Shaffer CM, Gaudieri S, Xu Y, Glazer AM, Mosley JD, Zhao S, Raychaudhuri S, Mallal S, Ye Z, Mayer JG, Brilliant MH, Hebbring SJ, Roden DM, et al. Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants. Science Translational Medicine. 9. PMID 28490672 DOI: 10.1126/Scitranslmed.Aai8708  0.733
2017 Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, ... ... Roden DM, et al. Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nature Genetics. PMID 28416818 DOI: 10.1038/Ng.3843  0.514
2017 Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, et al. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Assay and Drug Development Technologies. PMID 28379727 DOI: 10.1089/Adt.2016.772  0.48
2017 Manolio TA, Fowler DM, Starita LM, Haendel MA, MacArthur DG, Biesecker LG, Worthey E, Chisholm RL, Green ED, Jacob HJ, McLeod HL, Roden D, Rodriguez LL, Williams MS, Cooper GM, et al. Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research. Cell. 169: 6-12. PMID 28340351 DOI: 10.1016/J.Cell.2017.03.005  0.623
2017 Nadkarni GN, Galarneau G, Ellis SB, Nadukuru R, Zhang J, Scott SA, Schurmann C, Li R, Rasmussen-Torvik LJ, Kho AN, Hayes MG, Pacheco JA, Manolio TA, Chisholm RL, Roden DM, et al. Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans. Journal of the American College of Cardiology. 69: 1564-1574. PMID 28335839 DOI: 10.1016/J.Jacc.2017.01.040  0.433
2017 Dumitrescu L, Ritchie MD, Denny JC, El Rouby NM, McDonough CW, Bradford Y, Ramirez AH, Bielinski SJ, Basford MA, Chai HS, Peissig P, Carrell D, Pathak J, Rasmussen LV, Wang X, ... ... Roden DM, et al. Genome-wide study of resistant hypertension identified from electronic health records. Plos One. 12: e0171745. PMID 28222112 DOI: 10.1371/Journal.Pone.0171745  0.657
2017 Karnes JH, Shaffer CM, Bastarache L, Gaudieri S, Glazer AM, Steiner HE, Mosley JD, Mallal S, Denny JC, Phillips EJ, Roden DM. Comparison of HLA allelic imputation programs. Plos One. 12: e0172444. PMID 28207879 DOI: 10.1371/Journal.Pone.0172444  0.705
2017 Heit JA, Armasu SM, McCauley BM, Kullo IJ, Sicotte H, Pathak J, Chute CG, Gottesman O, Bottinger EP, Denny JC, Roden DM, Li R, Ritchie MD, de Andrade M. Identification of unique venous thromboembolism-susceptibility variants in African-Americans. Thrombosis and Haemostasis. PMID 28203683 DOI: 10.1160/Th16-08-0652  0.494
2016 Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, Hartwig FP, Horta BL, Hyppönen E, Power C, Moldovan M, van Iperen E, Hovingh GK, Demuth I, Norman K, ... ... Roden DM, et al. PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. The Lancet. Diabetes & Endocrinology. PMID 27908689 DOI: 10.1016/S2213-8587(16)30396-5  0.431
2016 Wiley LK, Vanhouten JP, Samuels DC, Aldrich MC, Roden DM, Peterson JF, Denny JC. STRATEGIES FOR EQUITABLE PHARMACOGENOMIC-GUIDED WARFARIN DOSING AMONG EUROPEAN AND AFRICAN AMERICAN INDIVIDUALS IN A CLINICAL POPULATION. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 22: 545-556. PMID 27897005  0.765
2016 Schildcrout JS, Denny JC, Roden DM. On the Potential of Preemptive Genotyping Towards Preventing Medication-Related Adverse Events: Results from the South Korean National Health Insurance Database. Drug Safety. PMID 27873192 DOI: 10.1007/S40264-016-0476-Z  0.446
2016 Lubitz SA, Yin X, Lin H, Kolek M, Smith JG, Trompet S, Rienstra M, Rost NS, Teixeira P, Almgren P, Anderson CD, Chen LY, Engström G, Ford I, Furie KL, ... ... Roden DM, et al. Genetic Risk Prediction of Atrial Fibrillation. Circulation. PMID 27793994 DOI: 10.1161/Circulationaha.116.024143  0.429
2016 Mosley JD, Van Driest SL, Wells QS, Shaffer CM, Edwards TL, Bastarache L, McCarty CA, Thompson W, Chute CG, Jarvik GP, Crosslin DR, Larson EB, Kullo IJ, Pacheco JA, Peissig PL, ... ... Roden DM, et al. Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile using Historical Data. Circulation. Cardiovascular Genetics. PMID 27780847 DOI: 10.1161/Circgenetics.116.001530  0.473
2016 Shekhar A, Lin X, Liu FY, Zhang J, Mo H, Bastarache L, Denny JC, Cox NJ, Delmar M, Roden DM, Fishman GI, Park DS. Transcription factor ETV1 is essential for rapid conduction in the heart. The Journal of Clinical Investigation. PMID 27775552 DOI: 10.1172/Jci87968  0.623
2016 Roden DM, Mosley JD, Denny JC. Finding a Needle in a QT Interval Big Data Haystack: The Role for Orthogonal Datasets. Journal of the American College of Cardiology. 68: 1765-1768. PMID 27737743 DOI: 10.1016/J.Jacc.2016.08.012  0.433
2016 Kolek MJ, Graves AJ, Xu M, Bian A, Teixeira PL, Shoemaker MB, Parvez B, Xu H, Heckbert SR, Ellinor PT, Benjamin EJ, Alonso A, Denny JC, Moons KG, Shintani AK, ... ... Roden DM, et al. Evaluation of a Prediction Model for the Development of Atrial Fibrillation in a Repository of Electronic Medical Records. Jama Cardiology. PMID 27732699 DOI: 10.1001/Jamacardio.2016.3366  0.566
2016 Daneshjou R, Cavallari LH, Weeke PE, Karczewski KJ, Drozda K, Perera MA, Johnson JA, Klein TE, Bustamante CD, Roden DM, Shaffer C, Denny JC, Zehnder JL, Altman RB. Population-specific single-nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans. Molecular Genetics & Genomic Medicine. 4: 513-520. PMID 27652279 DOI: 10.1002/Mgg3.226  0.438
2016 Iwuchukwu OF, Ramirez AH, Shi Y, Bowton EA, Kawai VK, Schildcrout JS, Roden DM, Denny JC, Stein CM. Genetic determinants of variability in warfarin response after the dose-titration phase. Pharmacogenetics and Genomics. PMID 27632229 DOI: 10.1097/Fpc.0000000000000244  0.628
2016 Teixeira PL, Wei WQ, Cronin RM, Mo H, VanHouten JP, Carroll RJ, LaRose E, Bastarache LA, Rosenbloom ST, Edwards TL, Roden DM, Lasko TA, Dart RA, Nikolai AM, Peissig PL, et al. Evaluating electronic health record data sources and algorithmic approaches to identify hypertensive individuals. Journal of the American Medical Informatics Association : Jamia. PMID 27497800 DOI: 10.1093/Jamia/Ocw071  0.79
2016 Denny JC, Bastarache L, Roden DM. Phenome-Wide Association Studies as a Tool to Advance Precision Medicine. Annual Review of Genomics and Human Genetics. PMID 27147087 DOI: 10.1146/Annurev-Genom-090314-024956  0.542
2016 Mosley JD, Witte JS, Larkin EK, Bastarache L, Shaffer CM, Karnes JH, Stein CM, Phillips E, Hebbring SJ, Brilliant MH, Mayer J, Ye Z, Roden DM, Denny JC. Identifying genetically driven clinical phenotypes using linear mixed models. Nature Communications. 7: 11433. PMID 27109359 DOI: 10.1038/Ncomms11433  0.513
2016 Joshi AD, Andersson C, Buch S, Stender S, Noordam R, Weng LC, Weeke PE, Auer PL, Boehm B, Chen C, Choi H, Curhan G, Denny JC, De Vivo I, Eicher JD, ... ... Roden DM, et al. Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-wide Association Studies. Gastroenterology. PMID 27094239 DOI: 10.1053/J.Gastro.2016.04.007  0.484
2016 Kirby JC, Speltz P, Rasmussen LV, Basford M, Gottesman O, Peissig PL, Pacheco JA, Tromp G, Pathak J, Carrell DS, Ellis SB, Lingren T, Thompson WK, Savova G, Haines J, ... Roden DM, et al. PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability. Journal of the American Medical Informatics Association : Jamia. PMID 27026615 DOI: 10.1093/Jamia/Ocv202  0.454
2016 Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, et al. The phenotypic legacy of admixture between modern humans and Neandertals. Science (New York, N.Y.). 351: 737-41. PMID 26912863 DOI: 10.1126/Science.Aad2149  0.5
2016 Bush WS, Crosslin DR, Obeng AO, Wallace J, Almoguera B, Basford MA, Bielinski SJ, Carrell DS, Connolly JJ, Crawford D, Doheny KF, Gallego CJ, Gordon AS, Keating B, Kirby J, ... ... Roden DM, et al. Genetic Variation among 82 Pharmacogenes: the PGRN-Seq data from the eMERGE Network. Clinical Pharmacology and Therapeutics. PMID 26857349 DOI: 10.1002/Cpt.350  0.526
2016 Van Driest SL, Wells QS, Stallings S, Bush WS, Gordon A, Nickerson DA, Kim JH, Crosslin DR, Jarvik GP, Carrell DS, Ralston JD, Larson EB, Bielinski SJ, Olson JE, Ye Z, ... ... Roden DM, et al. Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records. Jama. 315: 47-57. PMID 26746457 DOI: 10.1001/Jama.2015.17701  0.525
2016 Roden DM, Denny JC. Integrating electronic health record genotype and phenotype datasets to transform patient care. Clinical Pharmacology & Therapeutics. 99: 298-305. PMID 26667791 DOI: 10.1002/Cpt.321  0.455
2015 Dahlin A, Denny J, Roden DM, Brilliant MH, Ingram C, Kitchner TE, Linneman JG, Shaffer CM, Weeke P, Xu H, Kubo M, Tamari M, Clemmer GL, Ziniti J, McGeachie MJ, et al. CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids. Immunity, Inflammation and Disease. 3: 350-9. PMID 26734457 DOI: 10.1002/Iid3.73  0.451
2015 Schildcrout JS, Shi Y, Danciu I, Bowton E, Field JR, Pulley JM, Basford M, Gregg W, Cowan J, Harrell FE, Roden DM, Peterson JF, Denny JC. A prognostic model based on readily available clinical data enriched a preemptive pharmacogenetic testing program. Journal of Clinical Epidemiology. PMID 26628336 DOI: 10.1016/J.Jclinepi.2015.08.028  0.431
2015 Herr TM, Bielinski SJ, Bottinger E, Brautbar A, Brilliant M, Chute CG, Cobb BL, Denny JC, Hakonarson H, Hartzler AL, Hripcsak G, Kannry J, Kohane IS, Kullo IJ, Lin S, ... ... Roden DM, et al. Practical considerations in genomic decision support: The eMERGE experience. Journal of Pathology Informatics. 6: 50. PMID 26605115 DOI: 10.4103/2153-3539.165999  0.418
2015 Hoh BL, Gong Y, McDonough CW, Waters MF, Royster AJ, Sheehan TO, Burkley B, Langaee TY, Mocco J, Zuckerman SL, Mummareddy N, Stephens ML, Ingram C, Shaffer CM, Denny JC, ... ... Roden DM, et al. CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease. Journal of Neurosurgery. 1-6. PMID 26587656 DOI: 10.3171/2015.6.Jns15795  0.489
2015 Herr TM, Bielinski SJ, Bottinger E, Brautbar A, Brilliant M, Chute CG, Denny J, Freimuth RR, Hartzler A, Kannry J, Kohane IS, Kullo IJ, Lin S, Pathak J, Peissig P, ... ... Roden D, et al. A conceptual model for translating omic data into clinical action. Journal of Pathology Informatics. 6: 46. PMID 26430534 DOI: 10.4103/2153-3539.163985  0.506
2015 Gallego CJ, Burt A, Sundaresan AS, Ye Z, Shaw C, Crosslin DR, Crane PK, Fullerton SM, Hansen K, Carrell D, Kuivaniemi H, Derr K, de Andrade M, McCarty CA, Kitchner TE, ... ... Roden DM, et al. Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network. American Journal of Human Genetics. PMID 26365338 DOI: 10.1016/J.Ajhg.2015.08.008  0.451
2015 Mo H, Thompson WK, Rasmussen LV, Pacheco JA, Jiang G, Kiefer R, Zhu Q, Xu J, Montague E, Carrell DS, Lingren T, Mentch FD, Ni Y, Wehbe FH, Peissig PL, ... ... Roden DM, et al. Desiderata for computable representations of electronic health records-driven phenotype algorithms. Journal of the American Medical Informatics Association : Jamia. PMID 26342218 DOI: 10.1093/Jamia/Ocv112  0.46
2015 Karol SE, Yang W, Van Driest SL, Chang TY, Kaste S, Bowton E, Basford M, Bastarache L, Roden DM, Denny JC, Larsen E, Winick N, Carroll WL, Cheng C, Pei D, et al. Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia. Blood. PMID 26265699 DOI: 10.1182/Blood-2015-05-643601  0.469
2015 Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei WQ, Teixeira PL, Bastarache L, Crawford DC, Li R, Manolio TA, Bottinger EP, McCarty CA, ... ... Roden DM, et al. A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. The Pharmacogenomics Journal. PMID 26169577 DOI: 10.1038/Tpj.2015.51  0.722
2015 Sun J, Zhao M, Jia P, Wang L, Wu Y, Iverson C, Zhou Y, Bowton E, Roden DM, Denny JC, Aldrich MC, Xu H, Zhao Z. Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action. Plos Computational Biology. 11: e1004202. PMID 26083494 DOI: 10.1371/Journal.Pcbi.1004202  0.44
2015 Williams VS, Cresswell CJ, Ruspi G, Yang T, Atak TC, McLoughlin M, Ingram CD, Ramirez AH, Roden D, Armstrong M. Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 17: 635-41. PMID 25564553 DOI: 10.1093/Europace/Euu288  0.625
2015 Karnes JH, Cronin RM, Rollin J, Teumer A, Pouplard C, Shaffer CM, Blanquicett C, Bowton EA, Cowan JD, Mosley JD, Van Driest SL, Weeke PE, Wells QS, Bakchoul T, Denny JC, ... ... Roden DM, et al. A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record. Thrombosis and Haemostasis. 113: 772-81. PMID 25503805 DOI: 10.1160/Th14-08-0670  0.711
2015 Weeke P, Denny JC, Basterache L, Shaffer C, Bowton E, Ingram C, Darbar D, Roden DM. Examining rare and low-frequency genetic variants previously associated with lone or familial forms of atrial fibrillation in an electronic medical record system: a cautionary note. Circulation. Cardiovascular Genetics. 8: 58-63. PMID 25410959 DOI: 10.1161/Circgenetics.114.000718  0.496
2015 Naidoo D, Wu AC, Brilliant MH, Denny J, Ingram C, Kitchner TE, Linneman JG, McGeachie MJ, Roden DM, Shaffer CM, Shah A, Weeke P, Weiss ST, Xu H, Medina MW. A polymorphism in HLA-G modifies statin benefit in asthma. The Pharmacogenomics Journal. 15: 272-7. PMID 25266681 DOI: 10.1038/Tpj.2014.55  0.411
2015 Xu H, Aldrich MC, Chen Q, Liu H, Peterson NB, Dai Q, Levy M, Shah A, Han X, Ruan X, Jiang M, Li Y, Julien JS, Warner J, Friedman C, ... Roden DM, et al. Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality. Journal of the American Medical Informatics Association : Jamia. 22: 179-91. PMID 25053577 DOI: 10.1136/Amiajnl-2014-002649  0.442
2015 Triana TS, Farber-Eger E, Wang T, Roden D, Wells Q. Clinical Phenotypes Associated With Potentially Pathologic Variants In Cardiomyopathy-Associated Genes In A Large Electronic Medical Record Journal of the American College of Cardiology. 65. DOI: 10.1016/S0735-1097(15)60955-X  0.381
2014 Wei WQ, Feng Q, Weeke P, Bush W, Waitara MS, Iwuchukwu OF, Roden DM, Wilke RA, Stein CM, Denny JC. Creation and Validation of an EMR-based Algorithm for Identifying Major Adverse Cardiac Events while on Statins. Amia Joint Summits On Translational Science Proceedings Amia Summit On Translational Science. 2014: 112-9. PMID 25717410  0.657
2014 Jeff JM, Brown-Gentry K, Goodloe R, Ritchie MD, Denny JC, Kho AN, Armstrong LL, McClellan B, Mayo P, Allen M, Jin H, Gillani NB, Schnetz-Boutaud N, Dilks HH, Basford MA, ... ... Roden DM, et al. Replication of SCN5A Associations with Electrocardio-graphic Traits in African Americans from Clinical and Epidemiologic Studies. Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics. Evobio (Conference), Author. 2014: 939-951. PMID 25590050 DOI: 10.1007/978-3-662-45523-4_76  0.524
2014 Kawai VK, Cunningham A, Vear SI, Van Driest SL, Oginni A, Xu H, Jiang M, Li C, Denny JC, Shaffer C, Bowton E, Gage BF, Ray WA, Roden DM, Stein CM. Genotype and risk of major bleeding during warfarin treatment. Pharmacogenomics. 15: 1973-83. PMID 25521356 DOI: 10.2217/Pgs.14.153  0.468
2014 Iwuchukwu OF, Feng Q, Wei WQ, Jiang L, Jiang M, Xu H, Denny JC, Wilke RA, Krauss RM, Roden DM, Stein CM. Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting. Pharmacogenomics. 15: 1739-1747. PMID 25493567 DOI: 10.2217/Pgs.14.128  0.661
2014 Malinowski JR, Denny JC, Bielinski SJ, Basford MA, Bradford Y, Peissig PL, Carrell D, Crosslin DR, Pathak J, Rasmussen L, Pacheco J, Kho A, Newton KM, Li R, Kullo IJ, ... ... Roden DM, et al. Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network. Plos One. 9: e111301. PMID 25436638 DOI: 10.1371/Journal.Pone.0111301  0.488
2014 Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, ... ... Roden DM, et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease. The New England Journal of Medicine. 371: 2072-82. PMID 25390462 DOI: 10.1056/Nejmoa1405386  0.429
2014 Cronin RM, Field JR, Bradford Y, Shaffer CM, Carroll RJ, Mosley JD, Bastarache L, Edwards TL, Hebbring SJ, Lin S, Hindorff LA, Crane PK, Pendergrass SA, Ritchie MD, Crawford DC, ... ... Roden DM, et al. Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index. Frontiers in Genetics. 5: 250. PMID 25177340 DOI: 10.3389/Fgene.2014.00250  0.761
2014 Heatherly R, Denny JC, Haines JL, Roden DM, Malin BA. Size matters: how population size influences genotype-phenotype association studies in anonymized data. Journal of Biomedical Informatics. 52: 243-50. PMID 25038554 DOI: 10.1016/J.Jbi.2014.07.005  0.493
2014 Crawford DC, Crosslin DR, Tromp G, Kullo IJ, Kuivaniemi H, Hayes MG, Denny JC, Bush WS, Haines JL, Roden DM, McCarty CA, Jarvik GP, Ritchie MD. eMERGEing progress in genomics-the first seven years. Frontiers in Genetics. 5: 184. PMID 24987407 DOI: 10.3389/Fgene.2014.00184  0.486
2014 Rasmussen-Torvik LJ, Stallings SC, Gordon AS, Almoguera B, Basford MA, Bielinski SJ, Brautbar A, Brilliant MH, Carrell DS, Connolly JJ, Crosslin DR, Doheny KF, Gallego CJ, Gottesman O, Kim DS, ... ... Roden DM, et al. Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems. Clinical Pharmacology and Therapeutics. 96: 482-9. PMID 24960519 DOI: 10.1038/Clpt.2014.137  0.505
2014 Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, ... ... Roden DM, et al. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nature Genetics. 46: 826-36. PMID 24952745 DOI: 10.1038/Ng.3014  0.498
2014 Bowton E, Field JR, Wang S, Schildcrout JS, Van Driest SL, Delaney JT, Cowan J, Weeke P, Mosley JD, Wells QS, Karnes JH, Shaffer C, Peterson JF, Denny JC, Roden DM, et al. Biobanks and electronic medical records: enabling cost-effective research. Science Translational Medicine. 6: 234cm3. PMID 24786321 DOI: 10.1126/Scitranslmed.3008604  0.466
2014 Jeff JM, Armstrong LL, Ritchie MD, Denny JC, Kho AN, Basford MA, Wolf WA, Pacheco JA, Li R, Chisholm RL, Roden DM, Hayes MG, Crawford DC. Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans. Plos One. 9: e86931. PMID 24595071 DOI: 10.1371/Journal.Pone.0086931  0.469
2014 Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, ... ... Roden DM, et al. Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome. Journal of the American College of Cardiology. 63: 1430-7. PMID 24561134 DOI: 10.1016/J.Jacc.2014.01.031  0.582
2014 Caudle KE, Klein TE, Hoffman JM, Muller DJ, Whirl-Carrillo M, Gong L, McDonagh EM, Sangkuhl K, Thorn CF, Schwab M, Agundez JA, Freimuth RR, Huser V, Lee MT, Iwuchukwu OF, ... ... Roden D, et al. Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process. Current Drug Metabolism. 15: 209-17. PMID 24479687 DOI: 10.2174/1389200215666140130124910  0.332
2014 Karnes JH, Van Driest S, Bowton EA, Weeke PE, Mosley JD, Peterson JF, Denny JC, Roden DM. Using systems approaches to address challenges for clinical implementation of pharmacogenomics. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 6: 125-35. PMID 24319008 DOI: 10.1002/Wsbm.1255  0.481
2014 Oetjens M, Bush WS, Birdwell KA, Dilks HH, Bowton EA, Denny JC, Wilke RA, Roden DM, Crawford DC. Utilization of an EMR-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 253-264. PMID 24297552  0.449
2014 Van Driest SL, Shi Y, Bowton EA, Schildcrout JS, Peterson JF, Pulley J, Denny JC, Roden DM. Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing. Clinical Pharmacology and Therapeutics. 95: 423-31. PMID 24253661 DOI: 10.1038/Clpt.2013.229  0.551
2014 Kolek MJ, Parvez B, Muhammad R, Shoemaker MB, Blair MA, Stubblefield T, Kucera GA, Denny JC, Roden DM, Darbar D. A common variant on chromosome 4q25 is associated with prolonged PR interval in subjects with and without atrial fibrillation. The American Journal of Cardiology. 113: 309-13. PMID 24161141 DOI: 10.1016/J.Amjcard.2013.08.045  0.449
2014 Wei WQ, Feng Q, Jiang L, Waitara MS, Iwuchukwu OF, Roden DM, Jiang M, Xu H, Krauss RM, Rotter JI, Nickerson DA, Davis RL, Berg RL, Peissig PL, McCarty CA, et al. Characterization of statin dose response in electronic medical records. Clinical Pharmacology and Therapeutics. 95: 331-8. PMID 24096969 DOI: 10.1038/Clpt.2013.202  0.66
2014 Shameer K, Denny JC, Ding K, Jouni H, Crosslin DR, de Andrade M, Chute CG, Peissig P, Pacheco JA, Li R, Bastarache L, Kho AN, Ritchie MD, Masys DR, Chisholm RL, ... ... Roden DM, et al. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Human Genetics. 133: 95-109. PMID 24026423 DOI: 10.1007/S00439-013-1355-7  0.515
2014 Chang T, Yang W, Sara VDL, Kaste SC, Bowten EA, Basford M, Bastarache L, Roden DM, Denny JC, Mattano LA, Larsen EC, Winick NJ, Carroll WL, Cheng C, Pei D, et al. Glutamate Receptor Polymorphisms Contribute to Glucocorticoid-Associated Osteonecrosis Blood. 124: 367-367. DOI: 10.1182/Blood.V124.21.367.367  0.477
2014 Wijeyeratne YD, Muggenthaler M, Tanck MW, Schott J, Kyndt F, Probst V, Borggrefe M, McKeown P, Veltmann C, Crotti L, Schwartz P, Sharma S, Makita N, Roden D, Behr ER. 163 Genetic Modifiers in Carriers of the SCN5A E1784K Mutation with Variable Phenotypic Expression - Long QT3 / Brugada Syndrome Overlap Disease Heart. 100. DOI: 10.1136/Heartjnl-2014-306118.163  0.411
2014 Wijeyeratne YD, Muggenthaler M, Batchvarov V, Tanck M, Schott JJ, Kyndt F, Probst V, Shimizu W, Borggrefe M, McKeown P, Papadakis M, Veltmann C, Horie M, Crotti L, Schwartz P, ... ... Roden D, et al. 16Ethnicity and phenotype in the SCN5A E1784K mutation Europace. 16. DOI: 10.1093/Europace/Euu237.10  0.313
2013 Denny JC, Bastarache L, Ritchie MD, Carroll RJ, Zink R, Mosley JD, Field JR, Pulley JM, Ramirez AH, Bowton E, Basford MA, Carrell DS, Peissig PL, Kho AN, Pacheco JA, ... ... Roden DM, et al. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nature Biotechnology. 31: 1102-10. PMID 24270849 DOI: 10.1038/Nbt.2749  0.766
2013 Wells QS, Becker JR, Su YR, Mosley JD, Weeke P, D'Aoust L, Ausborn NL, Ramirez AH, Pfotenhauer JP, Naftilan AJ, Markham L, Exil V, Roden DM, Hong CC. Whole exome sequencing identifies a causal RBM20 mutation in a large pedigree with familial dilated cardiomyopathy. Circulation. Cardiovascular Genetics. 6: 317-26. PMID 23861363 DOI: 10.1161/CIRCGENETICS.113.000011  0.547
2013 Heatherly RD, Loukides G, Denny JC, Haines JL, Roden DM, Malin BA. Correction: Enabling Genomic-Phenomic Association Discovery without Sacrificing Anonymity. Plos One. 8. PMID 23825513 DOI: 10.1371/Annotation/Db45627A-50Ec-4C52-8B5F-95Dec75B1C80  0.429
2013 Perera MA, Cavallari LH, Limdi NA, Gamazon ER, Konkashbaev A, Daneshjou R, Pluzhnikov A, Crawford DC, Wang J, Liu N, Tatonetti N, Bourgeois S, Takahashi H, Bradford Y, Burkley BM, ... ... Roden DM, et al. Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. Lancet. 382: 790-6. PMID 23755828 DOI: 10.1016/S0140-6736(13)60681-9  0.421
2013 Gottesman O, Kuivaniemi H, Tromp G, Faucett WA, Li R, Manolio TA, Sanderson SC, Kannry J, Zinberg R, Basford MA, Brilliant M, Carey DJ, Chisholm RL, Chute CG, Connolly JJ, ... ... Roden DM, et al. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 15: 761-71. PMID 23743551 DOI: 10.1038/Gim.2013.72  0.481
2013 Ding K, de Andrade M, Manolio TA, Crawford DC, Rasmussen-Torvik LJ, Ritchie MD, Denny JC, Masys DR, Jouni H, Pachecho JA, Kho AN, Roden DM, Chisholm R, Kullo IJ. Genetic variants that confer resistance to malaria are associated with red blood cell traits in African-Americans: an electronic medical record-based genome-wide association study. G3 (Bethesda, Md.). 3: 1061-8. PMID 23696099 DOI: 10.1534/G3.113.006452  0.522
2013 Oetjens MT, Denny JC, Ritchie MD, Gillani NB, Richardson DM, Restrepo NA, Pulley JM, Dilks HH, Basford MA, Bowton E, Masys DR, Wilke RA, Roden DM, Crawford DC. Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records. Pharmacogenomics. 14: 735-44. PMID 23651022 DOI: 10.2217/Pgs.13.64  0.46
2013 Jeff JM, Ritchie MD, Denny JC, Kho AN, Ramirez AH, Crosslin D, Armstrong L, Basford MA, Wolf WA, Pacheco JA, Chisholm RL, Roden DM, Hayes MG, Crawford DC. Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. Annals of Human Genetics. 77: 321-32. PMID 23534349 DOI: 10.1111/Ahg.12023  0.693
2013 Ritchie MD, Denny JC, Zuvich RL, Crawford DC, Schildcrout JS, Bastarache L, Ramirez AH, Mosley JD, Pulley JM, Basford MA, Bradford Y, Rasmussen LV, Pathak J, Chute CG, Kullo IJ, ... ... Roden DM, et al. Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation. 127: 1377-85. PMID 23463857 DOI: 10.1161/Circulationaha.112.000604  0.654
2013 Heatherly RD, Loukides G, Denny JC, Haines JL, Roden DM, Malin BA. Enabling genomic-phenomic association discovery without sacrificing anonymity. Plos One. 8: e53875. PMID 23405076 DOI: 10.1371/Journal.Pone.0053875  0.496
2013 Denny JC, Schildcrout JS, Pulley JM, Roden DM. Response to "doubt about the feasibility of preemptive genotyping" Clinical Pharmacology and Therapeutics. 93: 234. PMID 23249779 DOI: 10.1038/Clpt.2012.223  0.389
2013 Behr ER, Roden D. Drug-induced arrhythmia: pharmacogenomic prescribing? European Heart Journal. 34: 89-95. PMID 23091201 DOI: 10.1093/Eurheartj/Ehs351  0.315
2013 Behr ER, January C, Schulze-Bahr E, Grace AA, Kääb S, Fiszman M, Gathers S, Buckman S, Youssef A, Pirmohamed M, Roden D. The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes. European Heart Journal. 34: 1958-63. PMID 22752616 DOI: 10.1093/Eurheartj/Ehs172  0.351
2013 Motsinger-Reif AA, Jorgenson E, Relling MV, Kroetz DL, Weinshilboum R, Cox NJ, Roden DM. Genome-wide association studies in pharmacogenomics: successes and lessons. Pharmacogenetics and Genomics. 23: 383-94. PMID 20639796 DOI: 10.1097/Fpc.0B013E32833D7B45  0.433
2013 Heit JA, de Andrade M, Armasu SM, Kullo IJ, Pathak J, Chute CG, Gottesman O, Bottinger EP, Denny JC, Roden DM, Li R, Ritchie MD. Genome-Wide Association Study (GWAS) Of Venous Thromboembolism (VTE) In African-Americans From The Electronic Medical Records & Genomics (eMERGE) Networkm Blood. 122: 458-458. DOI: 10.1182/Blood.V122.21.458.458  0.49
2013 Barc J, Bezzina C, Mizusawa Y, Remme C, Gourraud J, Verkerk A, Schwartz P, Guicheney P, Antzelevitch C, Schulze-Bahr E, Behr E, Tfelt-Hanson J, Kaab S, Watanabe H, Horie M, ... ... Roden D, et al. Genome-Wide Association Analysis Identifies 3 Common Variants Predisposing to Brugada Syndrome, a Rare Disease with High Risk of Sudden Cardiac Death Heart Rhythm. 10: 1743-1744. DOI: 10.1016/J.Hrthm.2013.09.020  0.404
2012 Rasmussen-Torvik LJ, Pacheco JA, Wilke RA, Thompson WK, Ritchie MD, Kho AN, Muthalagu A, Hayes MG, Armstrong LL, Scheftner DA, Wilkins JT, Zuvich RL, Crosslin D, Roden DM, Denny JC, et al. High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE. Clinical and Translational Science. 5: 394-9. PMID 23067351 DOI: 10.1111/J.1752-8062.2012.00446.X  0.469
2012 Schildcrout JS, Denny JC, Bowton E, Gregg W, Pulley JM, Basford MA, Cowan JD, Xu H, Ramirez AH, Crawford DC, Ritchie MD, Peterson JF, Masys DR, Wilke RA, Roden DM. Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping. Clinical Pharmacology and Therapeutics. 92: 235-42. PMID 22739144 DOI: 10.1038/Clpt.2012.66  0.484
2012 Parvez B, Vaglio J, Rowan S, Muhammad R, Kucera G, Stubblefield T, Carter S, Roden D, Darbar D. Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation Journal of the American College of Cardiology. 60: 539-545. PMID 22726630 DOI: 10.1016/J.Jacc.2012.01.070  0.344
2012 Roden DM, Xu H, Denny JC, Wilke RA. Electronic medical records as a tool in clinical pharmacology: Opportunities and challenges Clinical Pharmacology and Therapeutics. 91: 1083-1086. PMID 22534870 DOI: 10.1038/Clpt.2012.42  0.47
2012 Ramirez AH, Shi Y, Schildcrout JS, Delaney JT, Xu H, Oetjens MT, Zuvich RL, Basford MA, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley JM, Ritchie MD, ... ... Roden DM, et al. Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Pharmacogenomics. 13: 407-18. PMID 22329724 DOI: 10.2217/Pgs.11.164  0.651
2012 Delaney JT, Ramirez AH, Bowton E, Pulley JM, Basford MA, Schildcrout JS, Shi Y, Zink R, Oetjens M, Xu H, Cleator JH, Jahangir E, Ritchie MD, Masys DR, Roden DM, et al. Predicting clopidogrel response using DNA samples linked to an electronic health record. Clinical Pharmacology and Therapeutics. 91: 257-63. PMID 22190063 DOI: 10.1038/Clpt.2011.221  0.47
2011 Liu M, Jiang M, Kawai VK, Stein CM, Roden DM, Denny JC, Xu H. Modeling drug exposure data in electronic medical records: an application to warfarin Amia ... Annual Symposium Proceedings / Amia Symposium. Amia Symposium. 2011: 815-823. PMID 22195139  0.442
2011 Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford Y, Chai HS, Bastarache L, Zuvich R, Peissig P, Carrell D, Ramirez AH, Pathak J, Wilke RA, Rasmussen L, ... ... Roden DM, et al. Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. American Journal of Human Genetics. 89: 529-42. PMID 21981779 DOI: 10.1016/J.Ajhg.2011.09.008  0.694
2011 Xu H, Jiang M, Oetjens M, Bowton EA, Ramirez AH, Jeff JM, Basford MA, Pulley JM, Cowan JD, Wang X, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC. Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. Journal of the American Medical Informatics Association : Jamia. 18: 387-91. PMID 21672908 DOI: 10.1136/Amiajnl-2011-000208  0.752
2011 Tatonetti NP, Denny JC, Murphy SN, Fernald GH, Krishnan G, Castro V, Yue P, Tsao PS, Tsau PS, Kohane I, Roden DM, Altman RB. Detecting drug interactions from adverse-event reports: interaction between paroxetine and pravastatin increases blood glucose levels. Clinical Pharmacology and Therapeutics. 90: 133-42. PMID 21613990 DOI: 10.1038/Clpt.2011.83  0.481
2011 Pirmohamed M, Aithal G, Behr E, Daly A, Roden D. The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions. Clinical Pharmacology & Therapeutics. 89: 784-785. PMID 21593754 DOI: 10.1038/Clpt.2011.30  0.31
2011 Turner SD, Berg RL, Linneman JG, Peissig PL, Crawford DC, Denny JC, Roden DM, McCarty CA, Ritchie MD, Wilke RA. Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks Plos One. 6. PMID 21589926 DOI: 10.1371/Journal.Pone.0019586  0.483
2011 Wilke RA, Xu H, Denny JC, Roden DM, Krauss RM, McCarty CA, Davis RL, Skaar T, Lamba J, Savova G. The emerging role of electronic medical records in pharmacogenomics. Clinical Pharmacology and Therapeutics. 89: 379-86. PMID 21248726 DOI: 10.1038/Clpt.2010.260  0.477
2011 Altman RB, Kroemer HK, McCarty CA, Ratain MJ, Roden D. Pharmacogenomics: will the promise be fulfilled? Nature Reviews. Genetics. 12: 69-73. PMID 21116304 DOI: 10.1038/Nrg2920  0.344
2011 Ramirez AH, Schildcrout JS, Blakemore DL, Masys DR, Pulley JM, Basford MA, Roden DM, Denny JC. Modulators of normal electrocardiographic intervals identified in a large electronic medical record. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 8: 271-7. PMID 21044898 DOI: 10.1016/J.Hrthm.2010.10.034  0.645
2010 Denny JC, Ritchie MD, Crawford DC, Schildcrout JS, Ramirez AH, Pulley JM, Basford MA, Masys DR, Haines JL, Roden DM. Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation. 122: 2016-21. PMID 21041692 DOI: 10.1161/Circulationaha.110.948828  0.67
2010 Dumitrescu L, Ritchie MD, Brown-Gentry K, Pulley JM, Basford M, Denny JC, Oksenberg JR, Roden DM, Haines JL, Crawford DC. Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 12: 648-50. PMID 20733501 DOI: 10.1097/Gim.0B013E3181Efe2Df  0.467
2010 Schildcrout JS, Basford MA, Pulley JM, Masys DR, Roden DM, Wang D, Chute CG, Kullo IJ, Carrell D, Peissig P, Kho A, Denny JC. An analytical approach to characterize morbidity profile dissimilarity between distinct cohorts using electronic medical records. Journal of Biomedical Informatics. 43: 914-23. PMID 20688191 DOI: 10.1016/J.Jbi.2010.07.011  0.473
2010 Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. American Journal of Human Genetics. 86: 560-72. PMID 20362271 DOI: 10.1016/J.Ajhg.2010.03.003  0.707
2010 Chopra SS, Stroud DM, Watanabe H, Bennett JS, Burns CG, Wells KS, Yang T, Zhong TP, Roden DM. Voltage-gated sodium channels are required for heart development in zebrafish. Circulation Research. 106: 1342-50. PMID 20339120 DOI: 10.1161/CIRCRESAHA.109.213132  0.57
2010 Denny JC, Ritchie MD, Basford MA, Pulley JM, Bastarache L, Brown-Gentry K, Wang D, Masys DR, Roden DM, Crawford DC. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics (Oxford, England). 26: 1205-10. PMID 20335276 DOI: 10.1093/Bioinformatics/Btq126  0.496
2010 Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM. Erratum: Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record (American Journal of Human Genetics (2010) 86 (560-572)) American Journal of Human Genetics. 87. DOI: 10.1016/J.Ajhg.2010.06.018  0.503
2009 Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM. Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation. Circulation. Arrhythmia and Electrophysiology. 2: 268-75. PMID 19808477 DOI: 10.1161/Circep.108.779181  0.595
2007 Chopra SS, Watanabe H, Zhong TP, Roden DM. Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates. Bmc Evolutionary Biology. 7: 113. PMID 17623065 DOI: 10.1186/1471-2148-7-113  0.559
2007 Altman RB, Benowitz N, Gurwitz D, Lunshof J, Relling M, Lamba J, Wieben E, Mooney S, Giacomini K, Weiss S, Johnson JA, McLeod H, Flockhart D, Weinshilboum R, Shuldiner AR, ... Roden D, et al. Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing. Pharmacogenomics. 8: 519. PMID 17465717 DOI: 10.2217/14622416.8.5.519  0.373
Low-probability matches (unlikely to be authored by this person)
1989 Funck‐Brentano C, Kroemer H, Pavlou H, Woosley R, Roden D. Genetically-determined interaction between propafenone and low dose quinidine: role of active metabolites in modulating net drug effect. British Journal of Clinical Pharmacology. 27: 435-444. PMID 2719900 DOI: 10.1111/J.1365-2125.1989.Tb05391.X  0.298
2014 Mosley JD, Van Driest SL, Weeke PE, Delaney JT, Wells QS, Bastarache L, Roden DM, Denny JC. Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associations Plos One. 9. PMID 24949630 DOI: 10.1371/Journal.Pone.0100322  0.297
2009 Gudbjartsson DF, Holm H, Gretarsdottir S, Thorleifsson G, Walters GB, Thorgeirsson G, Gulcher J, Mathiesen EB, Njølstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, Kucera G, ... ... Roden D, et al. A sequence variant in ZFHX3 on 16q22 associates with a trial fibrillation and ischemic stroke Nature Genetics. 41: 876-878. PMID 19597491 DOI: 10.1038/Ng.417  0.295
2006 Simard C, Drolet B, Roden D. PharmGKB submission update: VII. PAT submissions of genetic variation in KCND3 to the PharmGKB network Pharmacological Reviews. 58: 136-137. DOI: 10.1124/Pr.58.2.1  0.295
2011 Scott SA, Sangkuhl K, Gardner EE, Stein CM, Hulot JS, Johnson JA, Roden DM, Klein TE, Shuldiner AR. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy. Clinical Pharmacology and Therapeutics. 90: 328-32. PMID 21716271 DOI: 10.1038/Clpt.2011.132  0.293
1998 Roden D, Willerson JT. Cardiovascular Drugs Review of Mechanisms and Clinical Applications Circulation. 97: 415-415. DOI: 10.1161/01.Cir.97.5.415  0.293
2011 Roden DM, Tyndale RF. Pharmacogenomics at the tipping point: challenges and opportunities. Clinical Pharmacology and Therapeutics. 89: 323-7. PMID 21326256 DOI: 10.1038/Clpt.2010.340  0.292
2018 Wijeyeratne YD, Tanck MW, Muir A, Bos JM, Denjoy I, Galvin J, Page S, Ohno S, Veltmann C, Crotti L, Roden D, Makita N, Probst V, Aiba T, Behr ER. P3815A genetic risk score predicts Brugada syndrome phenotype in SCN5A overlap syndrome European Heart Journal. 39. DOI: 10.1093/Eurheartj/Ehy563.P3815  0.292
2017 Farrell M, Yoneda Z, Montgomery J, Crawford D, Wray LL, Xu M, Kolek MJ, Richardson T, Lugo R, Metawee M, Michaud G, Estrada JC, Saavedra P, Shen S, Kanagasundram A, ... ... Roden D, et al. Non-pulmonary vein mediated atrial fibrillation: A novel sub-phenotype. Plos One. 12: e0184354. PMID 28880943 DOI: 10.1371/Journal.Pone.0184354  0.291
2001 Demolombe S, Franco D, Boer Pd, Kuperschmidt S, Roden D, Pereon Y, Jarry A, Moorman AFM, Escande D. Differential expression of KvLQT1 and its regulator IsK in mouse epithelia. American Journal of Physiology-Cell Physiology. 280. PMID 11208532 DOI: 10.1152/Ajpcell.2001.280.2.C359  0.289
2020 Lahrouchi N, Tadros R, Crotti L, Mizusawa Y, Postema PG, Beekman L, Walsh R, Hasegawa K, Barc J, Ernsting M, Turkowski KL, Mazzanti A, Beckmann BM, Shimamoto K, Diamant UB, ... ... Roden DM, et al. Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome. Circulation. PMID 32429735 DOI: 10.1161/Circulationaha.120.045956  0.289
1991 Turgeon J, Evans WE, Relling MV, Wilkinson GR, Roden DM. Phenotypic debrisoquine 4-hydroxylase activity among extensive metabolizers is unrelated to genotype as determined by the Xba-I restriction fragment length polymorphism. British Journal of Clinical Pharmacology. 32: 283-8. PMID 1685663 DOI: 10.1111/J.1365-2125.1991.Tb03900.X  0.284
2013 Behr ER, Ritchie MD, Tanaka T, Kääb S, Crawford DC, Nicoletti P, Floratos A, Sinner MF, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Zumhagen S, Guicheney P, Bishopric NH, ... ... Roden DM, et al. Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes. Plos One. 8: e78511. PMID 24223155 DOI: 10.1371/Journal.Pone.0078511  0.284
2015 Proost D, Vandeweyer G, Meester JA, Salemink S, Kempers M, Ingram C, Peeters N, Saenen J, Vrints C, Lacro RV, Roden D, Wuyts W, Dietz HC, Mortier G, Loeys BL, et al. Performant Mutation Identification Using Targeted Next-Generation Sequencing of 14 Thoracic Aortic Aneurysm Genes. Human Mutation. 36: 808-14. PMID 25907466 DOI: 10.1002/Humu.22802  0.284
2008 Roden DM, Pulley JM, Basford MA, Bernard GR, Clayton EW, Balser JR, Masys DR. Development of a large-scale de-identified DNA biobank to enable personalized medicine Clinical Pharmacology and Therapeutics. 84: 362-369. PMID 18500243 DOI: 10.1038/Clpt.2008.89  0.283
2022 Barc J, Tadros R, Glinge C, Chiang DY, Jouni M, Simonet F, Jurgens SJ, Baudic M, Nicastro M, Potet F, Offerhaus JA, Walsh R, Choi SH, Verkerk AO, Mizusawa Y, ... ... Roden D, et al. Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Nature Genetics. PMID 35210625 DOI: 10.1038/s41588-021-01007-6  0.282
2013 Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, ... ... Roden DM, et al. Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data. Plos One. 8: e81503. PMID 24349080 DOI: 10.1371/Journal.Pone.0081503  0.281
2020 Walsh R, Lahrouchi N, Tadros R, Kyndt F, Glinge C, Postema PG, Amin AS, Nannenberg EA, Ware JS, Whiffin N, Mazzarotto F, Škorić-Milosavljević D, Krijger C, Arbelo E, Babuty D, ... ... Roden DM, et al. Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 32893267 DOI: 10.1038/S41436-020-00946-5  0.271
2023 Lancaster MC, Chen HH, Shoemaker MB, Fleming MR, Baker JT, Evans G, Polikowsky HG, Samuels DC, Huff CD, Roden DM, Below JE. Detection of distant relatedness in biobanks for identification of undiagnosed carriers of a Mendelian disease variant: application to Long QT Syndrome. Research Square. PMID 37790303 DOI: 10.21203/rs.3.rs-3314860/v1  0.263
2013 Weeke P, Roden DM. Pharmacogenomics and cardiovascular disease. Current Cardiology Reports. 15: 376. PMID 23689943 DOI: 10.1007/s11886-013-0376-0  0.262
2021 Taliun D, Harris DN, Kessler MD, Carlson J, Szpiech ZA, Torres R, Taliun SAG, Corvelo A, Gogarten SM, Kang HM, Pitsillides AN, LeFaive J, Lee SB, Tian X, Browning BL, ... ... Roden D, et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 590: 290-299. PMID 33568819 DOI: 10.1038/s41586-021-03205-y  0.261
1992 Hallstrom AP, Bigger JT, Roden D, Friedman L, Akiyama T, Richardson DW, Rogers WJ, Waldo AL, Pratt CM, Capone RJ, Griffith L, Theroux PA, Barker AH, Woosley RL. Prognostic significance of ventricular premature depolarizations measured 1 year after myocardial infraction in patient with early postinfarction asymptomatic ventricular arrhythmia Journal of the American College of Cardiology. 20: 259-264. PMID 1378858 DOI: 10.1016/0735-1097(92)90089-6  0.261
2020 Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, Szeto MD, Liao X, Leventhal MJ, Nasser J, Chang K, Laurie C, Burugula BB, Gibson CJ, Lin AE, ... ... Roden DM, et al. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. PMID 33057201 DOI: 10.1038/s41586-020-2819-2  0.26
2017 Strauss DG, Vicente J, Johannesen L, Blinova K, Mason JW, Weeke P, Behr ER, Roden DM, Woosley R, Kosova G, Rosenberg MA, Newton-Cheh C. A Common Genetic Variant Risk Score is Associated with Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study. Circulation. PMID 28213480 DOI: 10.1161/Circulationaha.116.023980  0.26
2004 Roden DM. Human genomics and its impact on arrhythmias. Trends in Cardiovascular Medicine. 14: 112-6. PMID 15121159 DOI: 10.1016/J.TCM.2004.01.001  0.26
2016 Roden DM. Pharmacogenetic implementation lessons from the "real world". Clinical Pharmacology and Therapeutics. PMID 27981579 DOI: 10.1002/Cpt.584  0.259
2004 Moskowitz IP, Pizard A, Patel VV, Bruneau BG, Kim JB, Kupershmidt S, Roden D, Berul CI, Seidman CE, Seidman JG. The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development (Cambridge, England). 131: 4107-16. PMID 15289437 DOI: 10.1242/Dev.01265  0.259
1992 Birgersdotter U, Wong W, Turgeon J, Roden D. Stereoselective genetically-determined interaction between chronic flecainide and quinidine in patients with arrhythmias. British Journal of Clinical Pharmacology. 33: 275-280. PMID 1576047 DOI: 10.1111/J.1365-2125.1992.Tb04035.X  0.259
2024 Lennon NJ, Kottyan LC, Kachulis C, Abul-Husn NS, Arias J, Belbin G, Below JE, Berndt SI, Chung WK, Cimino JJ, Clayton EW, Connolly JJ, Crosslin DR, Dikilitas O, Velez Edwards DR, ... ... Roden DM, et al. Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations. Nature Medicine. PMID 38374346 DOI: 10.1038/s41591-024-02796-z  0.259
2012 Ashley EA, Hershberger RE, Caleshu C, Ellinor PT, Garcia JG, Herrington DM, Ho CY, Johnson JA, Kittner SJ, Macrae CA, Mudd-Martin G, Rader DJ, Roden DM, Scholes D, Sellke FW, et al. Genetics and cardiovascular disease: a policy statement from the American Heart Association. Circulation. 126: 142-57. PMID 22645291 DOI: 10.1161/Cir.0B013E31825B07F8  0.259
1984 Woosley RL, Wang T, Stone W, Siddoway L, Thompson K, Duff HJ, Cerskus I, Roden D. Pharmacology, electrophysiology, and pharmacokinetics of mexiletine American Heart Journal. 107: 1058-1065. PMID 6326558 DOI: 10.1016/0002-8703(84)90175-3  0.257
2010 Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PI, Mueller M, Lubitz SA, Fox E, Darbar D, Smith NL, Smith JD, Schnabel RB, ... ... Roden DM, et al. Common variants in KCNN3 are associated with lone atrial fibrillation. Nature Genetics. 42: 240-4. PMID 20173747 DOI: 10.1038/Ng.537  0.256
2018 van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP, Lyytikäinen LP, Müller C, Müller-Nurasyid M, ... ... Roden DM, et al. PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature Communications. 9: 2904. PMID 30046033 DOI: 10.1038/S41467-018-04766-9  0.256
2013 Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, ... ... Roden DM, et al. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nature Genetics. 45: 1044-9. PMID 23872634 DOI: 10.1038/Ng.2712  0.255
2023 Zhang X, Brody JA, Graff M, Highland HM, Chami N, Xu H, Wang Z, Ferrier K, Chittoor G, Josyula NS, Li X, Li Z, Allison MA, Becker DM, Bielak LF, ... ... Roden DM, et al. WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE. Medrxiv : the Preprint Server For Health Sciences. PMID 37662265 DOI: 10.1101/2023.08.21.23293271  0.254
1983 Duff HJ, Roden D, Primm RK, Oates JA, Woosley RL. Mexiletine in the treatment of resistant ventricular arrhythmias: enhancement of efficacy and reduction of dose-related side effects by combination with quinidine. Circulation. 67: 1124-1128. PMID 6831673 DOI: 10.1161/01.Cir.67.5.1124  0.254
2012 Lynch D, Delaney J, Kasasbeh E, Roden D, Cleator J. Evaluation Of The Association Of The F2R Ivs-14A/T Par-1 Polymorphism With Stent Thrombosis And Subsequent Cardiovascular Events In A Cohort Of Coronary Artery Disease Patients Journal of the American College of Cardiology. 59. DOI: 10.1016/S0735-1097(12)61400-4  0.254
2020 Roberts JD, Asaki SY, Mazzanti A, Bos JM, Tuleta I, Muir AR, Crotti L, Krahn AD, Kutyifa V, Shoemaker MB, Johnsrude CL, Aiba T, Marcondes L, Baban A, Udupa S, ... ... Roden DM, et al. An International Multi-Center Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition. Circulation. PMID 31941373 DOI: 10.1161/Circulationaha.119.043114  0.253
2020 Ntalla I, Weng LC, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD, Roselli C, Barnes MR, Mifsud B, Warren HR, Hayward C, Marten J, Cranley JJ, ... ... Roden DM, et al. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications. 11: 2542. PMID 32439900 DOI: 10.1038/S41467-020-15706-X  0.253
2018 Giudicessi JR, Roden DM, Wilde AAM, Ackerman MJ. Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing. Circulation. 137: 619-630. PMID 29431662 DOI: 10.1161/CIRCULATIONAHA.117.030142  0.253
2016 Hall JL, Ryan JJ, Bray BE, Brown C, Lanfear D, Newby LK, Relling MV, Risch NJ, Roden DM, Shaw SY, Tcheng JE, Tenenbaum J, Wang TN, Weintraub WS. Merging Electronic Health Record Data and Genomics for Cardiovascular Research: A Science Advisory From the American Heart Association. Circulation. Cardiovascular Genetics. PMID 26976545 DOI: 10.1161/Hcg.0000000000000029  0.252
2015 Behr ER, Savio-Galimberti E, Barc J, Holst AG, Petropoulou E, Prins BP, Jabbari J, Torchio M, Berthet M, Mizusawa Y, Yang T, Nannenberg EA, Dagradi F, Weeke P, Bastiaenan R, ... ... Roden DM, et al. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study. Cardiovascular Research. 106: 520-9. PMID 25691538 DOI: 10.1093/Cvr/Cvv042  0.252
2002 Yang P, Kanki H, Drolet B, Yang T, Wei J, Viswanathan PC, Hohnloser SH, Shimizu W, Schwartz PJ, Stanton M, Murray KT, Norris K, George AL, Roden DM. Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation. 105: 1943-8. PMID 11997281 DOI: 10.1161/01.Cir.0000014448.19052.4C  0.252
2020 Shoemaker MB, Shah RL, Roden DM, Perez MV. How Will Genetics Inform the Clinical Care of Atrial Fibrillation? Circulation Research. 127: 111-127. PMID 32716712 DOI: 10.1161/CIRCRESAHA.120.316365  0.25
2022 Ghouse J, Tragante V, Muhammad A, Ahlberg G, Skov MW, Roden DM, Jonsdottir I, Andreasen L, Lundegaard PR, Trudsø LC, Banasik K, Brunak S, Ostrowski SR, Torp-Pedersen C, Pedersen OV, et al. Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci. European Heart Journal. PMID 35751511 DOI: 10.1093/eurheartj/ehac322  0.248
2001 Franco D, Demolombe S, Kupershmidt S, Dumaine R, Dominguez JN, Roden D, Antzelevitch C, Escande D, Moorman AFM. Divergent expression of delayed rectifier K(+) channel subunits during mouse heart development. Cardiovascular Research. 52: 65-75. PMID 11557234 DOI: 10.1016/S0008-6363(01)00349-2  0.246
2022 Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang Y, Raghavan S, Miao J, Arias JD, Graham SE, Mukamel RE, Spracklen CN, ... ... Roden DM, et al. A saturated map of common genetic variants associated with human height. Nature. PMID 36224396 DOI: 10.1038/s41586-022-05275-y  0.244
2018 Thorolfsdottir RB, Sveinbjornsson G, Sulem P, Nielsen JB, Jonsson S, Halldorsson GH, Melsted P, Ivarsdottir EV, Davidsson OB, Kristjansson RP, Thorleifsson G, Helgadottir A, Gretarsdottir S, Norddahl G, Rajamani S, ... ... Roden DM, et al. Coding variants in and increase risk of atrial fibrillation. Communications Biology. 1: 68. PMID 30271950 DOI: 10.1038/s42003-018-0068-9  0.244
2011 Parvez B, Chopra N, Rowan S, Vaglio J, Muhammad R, Roden D, Darbar D. A Common β-Adrenergic Receptor Polymorphism Modulates Response to Rate Control in Atrial Fibrillation Heart Rhythm. 8: 1825. DOI: 10.1016/J.Hrthm.2011.09.045  0.244
2022 Wainschtein P, Jain D, Zheng Z, Cupples LA, Shadyab AH, McKnight B, Shoemaker BM, Mitchell BD, Psaty BM, Kooperberg C, Liu CT, Albert CM, Roden D, Chasman DI, Darbar D, et al. Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. Nature Genetics. PMID 35256806 DOI: 10.1038/s41588-021-00997-7  0.243
2009 Roden DM, Stein CM. Clopidogrel and the concept of high-risk pharmacokinetics. Circulation. 119: 2127-30. PMID 19398674 DOI: 10.1161/Circulationaha.109.865907  0.243
2017 Mosley JD, Shoemaker MB, Wells QS, Darbar D, Shaffer CM, Edwards TL, Bastarache L, McCarty CA, Thompson W, Chute CG, Jarvik GP, Crosslin DR, Larson EB, Kullo IJ, Pacheco JA, ... ... Roden DM, et al. Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes. Circulation. Cardiovascular Genetics. 10. PMID 28416512 DOI: 10.1161/Circgenetics.116.001482  0.242
2020 Giles JB, Rollin J, Shaffer CM, Steiner HE, Momozawa Y, Stanaway I, Mushiroda T, Pouplard C, Heddle N, Kubo M, Phillips E, Warkentin TE, Gruel Y, Greinacher A, Roden D, et al. Genome-Wide Association Study Identifies Variation in ABO As Risk Factor for Platelet Reactivity in Heparin-Induced Thrombocytopenia Blood. 136: 38-39. DOI: 10.1182/blood-2020-139651  0.242
2013 Manolio TA, Chisholm RL, Ozenberger B, Roden DM, Williams MS, Wilson R, Bick D, Bottinger EP, Brilliant MH, Eng C, Frazer KA, Korf B, Ledbetter DH, Lupski JR, Marsh C, et al. Implementing genomic medicine in the clinic: the future is here. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 15: 258-67. PMID 23306799 DOI: 10.1097/01.Ogx.0000435523.89711.77  0.24
2022 Piekos JA, Hellwege JN, Zhang Y, Torstenson ES, Jarvik GP, Dikilitas O, Kullo IJ, Schaid DJ, Crosslin DR, Pendergrass SA, Lee MTM, Roden D, Denny JC, Edwards TL, Velez Edwards DR. Uterine fibroid polygenic risk score (PRS) associates and predicts risk for uterine fibroid. Human Genetics. PMID 35226188 DOI: 10.1007/s00439-022-02442-z  0.24
2013 Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, ... ... Roden DM, et al. Erratum: Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death (Nature Genetics (2013) 45 (1044-1049)) Nature Genetics. 45. DOI: 10.1038/Ng1113-1409B  0.239
2024 Seagle HM, Hellwege JN, Mautz BS, Li C, Xu Y, Zhang S, Roden DM, McGregor TL, Velez Edwards DR, Edwards TL. Evidence of recent and ongoing admixture in the U.S. and influences on health and disparities. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 29: 374-388. PMID 38160293  0.237
2010 Roden DM, Kannankeri PJ, Darbar D. Arrhythmia pharmacogenomics: methodological considerations. Current Pharmaceutical Design. 15: 3734-41. PMID 19925424 DOI: 10.2174/138161209789649529  0.237
2017 Thorolfsdottir RB, Sveinbjornsson G, Sulem P, Helgadottir A, Gretarsdottir S, Benonisdottir S, Magnusdottir A, Davidsson OB, Rajamani S, Roden DM, Darbar D, Pedersen TR, Sabatine MS, Jonsdottir I, Arnar DO, et al. A Missense Variant in PLEC Increases Risk of Atrial Fibrillation. Journal of the American College of Cardiology. 70: 2157-2168. PMID 29050564 DOI: 10.1016/j.jacc.2017.09.005  0.234
2019 Roden DM, McLeod HL, Relling MV, Williams MS, Mensah GA, Peterson JF, Van Driest SL. Pharmacogenomics. Lancet (London, England). PMID 31395440 DOI: 10.1016/S0140-6736(19)31276-0  0.233
2014 Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, ... Roden DM, et al. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Clinical Pharmacology and Therapeutics. 96: 370-9. PMID 24853734 DOI: 10.1038/Clpt.2014.109  0.23
2016 Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JJ, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin. Clinical Pharmacology and Therapeutics. PMID 27415606 DOI: 10.1002/Cpt.428  0.23
2008 Cooper GM, Johnson JA, Langaee TY, Feng H, Stanaway IB, Schwarz UI, Ritchie MD, Stein CM, Roden DM, Smith JD, Veenstra DL, Rettie AE, Rieder MJ. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood. 112: 1022-7. PMID 18535201 DOI: 10.1182/Blood-2008-01-134247  0.23
1992 Li P, Benitez J, Roden D, Branch RA. Angiotensin II facilitates tricyclic antidepressant-induced changes in QRS-duration in the rat Clinical Toxicology. 30: 83-98. PMID 1542151 DOI: 10.3109/15563659208994448  0.228
2000 Sesti F, Abbott GW, Wei J, Murray KT, Saksena S, Schwartz PJ, Priori SG, Roden DM, George AL, Goldstein SA. A common polymorphism associated with antibiotic-induced cardiac arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. 97: 10613-8. PMID 10984545 DOI: 10.1073/Pnas.180223197  0.228
2007 Mohler PJ, Le Scouarnec S, Denjoy I, Lowe JS, Guicheney P, Caron L, Driskell IM, Schott JJ, Norris K, Leenhardt A, Kim RB, Escande D, Roden DM. Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes. Circulation. 115: 432-41. PMID 17242276 DOI: 10.1161/Circulationaha.106.656512  0.228
2013 Kullo IJ, Jarvik GP, Manolio TA, Williams MS, Roden DM. Leveraging the electronic health record to implement genomic medicine. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 15: 270-1. PMID 23018749 DOI: 10.1038/Gim.2012.131  0.227
2016 Husser D, Ueberham L, Dinov B, Kosiuk J, Kornej J, Hindricks G, Shoemaker MB, Roden DM, Bollmann A, Büttner P. Genomic contributors to atrial electroanatomical remodeling and atrial fibrillation progression: Pathway enrichment analysis of GWAS data. Scientific Reports. 6: 36630. PMID 27857207 DOI: 10.1038/srep36630  0.227
2022 Lukas Laws J, Lancaster MC, Ben Shoemaker M, Stevenson WG, Hung RR, Wells Q, Marshall Brinkley D, Hughes S, Anderson K, Roden D, Stevenson LW. Arrhythmias as Presentation of Genetic Cardiomyopathy. Circulation Research. 130: 1698-1722. PMID 35617362 DOI: 10.1161/CIRCRESAHA.122.319835  0.226
2006 Roden DM. Long QT syndrome: reduced repolarization reserve and the genetic link. Journal of Internal Medicine. 259: 59-69. PMID 16336514 DOI: 10.1111/j.1365-2796.2005.01589.x  0.226
2016 Roden DM. Cardiovascular pharmacogenomics: current status and future directions. Journal of Human Genetics. 61: 79-85. PMID 26178435 DOI: 10.1038/jhg.2015.78  0.225
2013 Darbar D, Roden DM. Genetic mechanisms of atrial fibrillation: impact on response to treatment. Nature Reviews. Cardiology. 10: 317-29. PMID 23591267 DOI: 10.1038/nrcardio.2013.53  0.225
2011 Jeff JM, Brown-Gentry K, Buxbaum SG, Sarpong DF, Taylor HA, George AL, Roden DM, Crawford DC. SCN5A variation is associated with electrocardiographic traits in the Jackson Heart Study. Circulation. Cardiovascular Genetics. 4: 139-44. PMID 21325150 DOI: 10.1161/CIRCGENETICS.110.958124  0.224
2009 Milan DJ, Kim AM, Winterfield JR, Jones IL, Pfeufer A, Sanna S, Arking DE, Amsterdam AH, Sabeh KM, Mably JD, Rosenbaum DS, Peterson RT, Chakravarti A, Kääb S, Roden DM, et al. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Circulation. 120: 553-9. PMID 19652097 DOI: 10.1161/Circulationaha.108.821082  0.222
2005 Zhang M, Houamed K, Kupershmidt S, Roden D, Satin LS. Pharmacological properties and functional role of Kslow current in mouse pancreatic beta-cells: SK channels contribute to Kslow tail current and modulate insulin secretion. The Journal of General Physiology. 126: 353-63. PMID 16186562 DOI: 10.1085/Jgp.200509312  0.222
2020 Wijeyeratne YD, Tanck MW, Mizusawa Y, Batchvarov V, Barc J, Crotti L, Bos JM, Tester DJ, Muir A, Veltmann C, Ohno S, Page SP, Galvin J, Tadros R, Muggenthaler M, ... ... Roden DM, et al. Mutation Type and a Genetic Risk Score Associate Variably with Brugada Syndrome Phenotype in Families. Circulation. Genomic and Precision Medicine. PMID 33164571 DOI: 10.1161/CIRCGEN.120.002911  0.222
2012 Lieb W, Völzke H, Pulley JM, Roden DM, Kroemer HK. Strategies for personalized medicine-based research and implementation in the clinical workflow. Clinical Pharmacology and Therapeutics. 92: 443-5. PMID 22910438 DOI: 10.1038/clpt.2012.119  0.221
1990 Funk‐Brentano C, Silberstein D, Roden D, Wood A, Woosley R. A mechanism of D-(+)-sotalol effects on heart rate not related to beta-adrenoceptor antagonism. British Journal of Clinical Pharmacology. 30: 195-202. PMID 2169833 DOI: 10.1111/J.1365-2125.1990.Tb03765.X  0.221
2020 Shoemaker MB, Husser D, Roselli C, Al Jazairi M, Chrispin J, Kühne M, Neumann B, Knight S, Sun H, Mohanty S, Shaffer C, Thériault S, Rinke LL, Siland JE, Crawford DM, ... ... Roden DM, et al. Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation. Circulation. Arrhythmia and Electrophysiology. PMID 32078373 DOI: 10.1161/Circep.119.007676  0.219
2011 Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, et al. Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. Plos One. 6: e24593. PMID 21980348 DOI: 10.1371/Journal.Pone.0024593  0.218
2022 Barc J, Tadros R, Glinge C, Chiang DY, Jouni M, Simonet F, Jurgens SJ, Baudic M, Nicastro M, Potet F, Offerhaus JA, Walsh R, Choi SH, Verkerk AO, Mizusawa Y, ... ... Roden D, et al. Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Nature Genetics. PMID 35474365 DOI: 10.1038/s41588-022-01079-y  0.218
2024 O'Neill MJ, Ng CA, Aizawa T, Sala L, Bains S, Denjoy I, Winbo A, Ullah R, Shen Q, Tan CY, Kozek K, Vanags LR, Mitchell DW, Shen A, Wada Y, ... ... Roden DM, et al. Prognostic Value of Multiplexed Assays of Variant Effect and Automated Patch-clamping for -LQTS Risk Stratification. Medrxiv : the Preprint Server For Health Sciences. PMID 38370760 DOI: 10.1101/2024.02.01.24301443  0.217
2018 Lukács Krogager M, Skals RK, Appel EVR, Schnurr TM, Engelbrechtsen L, Have CT, Pedersen O, Engstrøm T, Roden DM, Gislason G, Poulsen HE, Køber L, Stender S, Hansen T, Grarup N, et al. Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography. Plos One. 13: e0208645. PMID 30566436 DOI: 10.1371/journal.pone.0208645  0.216
2019 Glessner JT, Li J, Desai A, Palmer M, Kim D, Lucas AM, Chang X, Connolly JJ, Almoguera B, Harley JB, Jarvik GP, Ritchie MD, Sleiman PMA, Roden DM, Crosslin D, et al. CNV Association of Diverse Clinical Phenotypes from eMERGE reveals novel disease biology underlying cardiovascular disease. International Journal of Cardiology. PMID 31447229 DOI: 10.1016/J.Ijcard.2019.07.058  0.215
2006 Motsinger AA, Donahue BS, Brown NJ, Roden DM, Ritchie MD. Risk factor interactions and genetic effects associated with post-operative atrial fibrillation. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 584-95. PMID 17094271  0.214
2015 Bowton EA, Collier SP, Wang X, Sutcliffe CB, Van Driest SL, Couch LJ, Herrera M, Jerome RN, Slebos RJ, Alborn WE, Liebler DC, McNaughton CD, Mernaugh RL, Wells QS, Brown NJ, ... Roden DM, et al. Phenotype-Driven Plasma Biobanking Strategies and Methods. Journal of Personalized Medicine. 5: 140-152. PMID 26110578 DOI: 10.3390/jpm5020140  0.214
2015 Van Driest SL, McGregor TL, Velez Edwards DR, Saville BR, Kitchner TE, Hebbring SJ, Brilliant M, Jouni H, Kullo IJ, Creech CB, Kannankeril PJ, Vear SI, Brothers KB, Bowton EA, Shaffer CM, ... ... Roden DM, et al. Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy. Plos One. 10: e0127791. PMID 26030142 DOI: 10.1371/Journal.Pone.0127791  0.214
2022 Mukherjee S, Cassini TA, Hu N, Yang T, Li B, Shen W, Moth CW, Rinker DC, Sheehan JH, Cogan JD, Newman JH, Hamid R, Macdonald RL, Roden DM, Meiler J, et al. Personalized structural biology reveals the molecular mechanisms underlying heterogeneous epileptic phenotypes caused by KCNC2 variants. Hgg Advances. 3: 100131. PMID 36035247 DOI: 10.1016/j.xhgg.2022.100131  0.213
2000 Chiang CE, Roden DM. The long QT syndromes: genetic basis and clinical implications. Journal of the American College of Cardiology. 36: 1-12. PMID 10898405 DOI: 10.1016/S0735-1097(00)00716-6  0.213
2004 Brame CJ, Boutaud O, Davies SS, Yang T, Oates JA, Roden D, Roberts LJ. Modification of proteins by isoketal-containing oxidized phospholipids. The Journal of Biological Chemistry. 279: 13447-51. PMID 14715668 DOI: 10.1074/Jbc.M313349200  0.213
2020 Verma SS, Bergmeijer TO, Gong L, Reny JL, Lewis JP, Mitchell BD, Alexopoulos D, Aradi D, Altman RB, Bliden K, Bradford Y, Campo G, Chang K, Cleator JH, Déry JP, ... ... Roden DM, et al. Genome-wide association study of platelet reactivity and cardiovascular response in patients treated with clopidogrel: a study by the International Clopidogrel Pharmacogenomics Consortium (ICPC). Clinical Pharmacology and Therapeutics. PMID 32472697 DOI: 10.1002/Cpt.1911  0.212
2022 Giles J, Steiner HE, Rollin J, Shaffer C, Momozawa Y, Mushiroda T, Inai C, Selleng K, Thiele T, Pouplard C, Heddle NM, Kubo M, Miller EC, Martinez KL, Phillips EJ, ... ... Roden DM, et al. Genome-wide association study of platelet factor 4/heparin antibodies in heparin-induced thrombocytopenia. Blood Advances. PMID 35533259 DOI: 10.1182/bloodadvances.2022007673  0.211
2007 Wilke RA, Lin DW, Roden DM, Watkins PB, Flockhart D, Zineh I, Giacomini KM, Krauss RM. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nature Reviews. Drug Discovery. 6: 904-16. PMID 17971785 DOI: 10.1038/Nrd2423  0.211
2007 Kannankeril PJ, Roden DM. Drug-induced long QT and torsade de pointes: recent advances. Current Opinion in Cardiology. 22: 39-43. PMID 17143043 DOI: 10.1097/HCO.0b013e32801129eb  0.21
2014 Weeke P, Parvez B, Blair M, Short L, Ingram C, Kucera G, Stubblefield T, Roden DM, Darbar D. Candidate gene approach to identifying rare genetic variants associated with lone atrial fibrillation. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 11: 46-52. PMID 24120998 DOI: 10.1016/j.hrthm.2013.10.025  0.21
2022 Vaitinadin NS, Shi M, Shaffer CM, Farber-Eger E, Lowery BD, Agrawal V, Gupta DK, Roden DM, Wells QS, Mosley JD. Genetic Determinants of Body Mass Index and Fasting Glucose Are Mediators of Grade 1 Diastolic Dysfunction. Journal of the American Heart Association. e025578. PMID 35656995 DOI: 10.1161/JAHA.122.025578  0.209
2005 DONAHUE B, DARBAR D, GEORGEJR A, LI C, BROWN N, RITCHIE M, RODEN D. Pharmacogenomics of atrial fibrillation Clinical Pharmacology & Therapeutics. 77: P7-P7. DOI: 10.1016/J.Clpt.2004.11.029  0.208
2006 Roden DM. Proarrhythmia as a pharmacogenomic entity: a critical review and formulation of a unifying hypothesis. Cardiovascular Research. 67: 419-25. PMID 15936006 DOI: 10.1016/J.CARDIORES.2005.04.022  0.208
2013 Roden DM. Cardiovascular pharmacogenomics: the future of cardiovascular therapeutics? The Canadian Journal of Cardiology. 29: 58-66. PMID 23200096 DOI: 10.1016/j.cjca.2012.07.845  0.208
2022 Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, Straka RJ, Gong L, Tuteja S, Wilke RA, Wadelius M, Larson EA, Roden DM, Klein TE, Yee SW, Krauss RM, et al. The Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for SLCO1B1, ABCG2, and CYP2C9 and statin-associated musculoskeletal symptoms. Clinical Pharmacology and Therapeutics. PMID 35152405 DOI: 10.1002/cpt.2557  0.207
2022 Nakao T, Bick AG, Taub MA, Zekavat SM, Uddin MM, Niroula A, Carty CL, Lane J, Honigberg MC, Weinstock JS, Pampana A, Gibson CJ, Griffin GK, Clarke SL, Bhattacharya R, ... ... Roden DM, et al. Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential. Science Advances. 8: eabl6579. PMID 35385311 DOI: 10.1126/sciadv.abl6579  0.207
2011 Kannankeril P, Roden DM, Darbar D. Drug-induced long QT syndrome. Pharmacological Reviews. 62: 760-81. PMID 21079043 DOI: 10.1124/pr.110.003723  0.206
1999 Priori SG, Barhanin J, Hauer RN, Haverkamp W, Jongsma HJ, Kleber AG, McKenna WJ, Roden DM, Rudy Y, Schwartz K, Schwartz PJ, Towbin JA, Wilde AM. Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II. Circulation. 99: 518-28. PMID 9927398 DOI: 10.1161/01.Cir.99.4.518  0.206
2016 Mital S, Musunuru K, Garg V, Russell MW, Lanfear DE, Gupta RM, Hickey KT, Ackerman MJ, Perez MV, Roden DM, Woo D, Fox CS, Ware S. Enhancing Literacy in Cardiovascular Genetics: A Scientific Statement From the American Heart Association. Circulation. Cardiovascular Genetics. PMID 27672144 DOI: 10.1161/Hcg.0000000000000031  0.206
2016 Yagihara N, Watanabe H, Barnett P, Duboscq-Bidot L, Thomas AC, Yang P, Ohno S, Hasegawa K, Kuwano R, Chatel S, Redon R, Schott JJ, Probst V, Koopmann TT, Bezzina CR, ... ... Roden DM, et al. Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes. Journal of the American Heart Association. 5. PMID 27625342 DOI: 10.1161/JAHA.116.003644  0.206
1999 Roden DM, Balser JR. A plethora of mechanisms in the HERG-related long QT syndrome: Genetics meets electrophysiology Cardiovascular Research. 44: 242-246. PMID 10690299 DOI: 10.1016/S0008-6363(99)00224-2  0.205
2014 Weeke P, Roden DM. Applied pharmacogenomics in cardiovascular medicine. Annual Review of Medicine. 65: 81-94. PMID 24111889 DOI: 10.1146/annurev-med-101712-122545  0.205
2018 Choi SH, Weng LC, Roselli C, Lin H, Haggerty CM, Shoemaker MB, Barnard J, Arking DE, Chasman DI, Albert CM, Chaffin M, Tucker NR, Smith JD, Gupta N, Gabriel S, ... ... Roden DM, et al. Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation. Jama. 320: 2354-2364. PMID 30535219 DOI: 10.1001/Jama.2018.18179  0.205
2005 Crotti L, Lundquist AL, Insolia R, Pedrazzini M, Ferrandi C, De Ferrari GM, Vicentini A, Yang P, Roden DM, George AL, Schwartz PJ. KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome. Circulation. 112: 1251-8. PMID 16116052 DOI: 10.1161/Circulationaha.105.549071  0.205
2018 Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, ... ... Roden DM, et al. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. The Lancet. Respiratory Medicine. PMID 30527956 DOI: 10.1016/S2213-2600(18)30409-0  0.204
2012 Ellinor PT, Lunetta KL, Albert CM, Glazer NL, Ritchie MD, Smith AV, Arking DE, Müller-Nurasyid M, Krijthe BP, Lubitz SA, Bis JC, Chung MK, Dörr M, Ozaki K, Roberts JD, ... ... Roden DM, et al. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nature Genetics. 44: 670-5. PMID 22544366 DOI: 10.1038/Ng.2261  0.204
2011 Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, ... ... Roden DM, et al. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation. 124: 1001-11. PMID 21824921 DOI: 10.1161/Circulationaha.110.987248  0.203
2017 Song W, Milne G, Fahrenholz J, Agrawal V, Clark D, Li W, McPherson J, Oates J, Roden D, Linton M. A Patient With Elevated Plasma High Density Lipoprotein (HDL) and Facial Flushing Journal of Clinical Lipidology. 11: 794. DOI: 10.1016/J.Jacl.2017.04.037  0.203
2006 Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini KM, Johnson JA, Krauss RM, McLeod HL, Ratain MJ, Relling MV, Ring HZ, Shuldiner AR, Weinshilboum RM, Weiss ST. Pharmacogenomics: challenges and opportunities. Annals of Internal Medicine. 145: 749-57. PMID 17116919 DOI: 10.7326/0003-4819-145-10-200611210-00007  0.203
2016 MacRae CA, Roden DM, Loscalzo J. The Future of Cardiovascular Therapeutics. Circulation. 133: 2610-7. PMID 27324356 DOI: 10.1161/Circulationaha.116.023555  0.203
2004 Petersen CI, McFarland TR, Stepanovic SZ, Yang P, Reiner DJ, Hayashi K, George AL, Roden DM, Thomas JH, Balser JR. In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. 101: 11773-8. PMID 15280551 DOI: 10.1073/Pnas.0306005101  0.202
2011 Gong IY, Tirona RG, Schwarz UI, Crown N, Dresser GK, Larue S, Langlois N, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Carrier M, Forgie M, Wells PS, et al. Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy. Blood. 118: 3163-71. PMID 21725053 DOI: 10.1182/Blood-2011-03-345173  0.202
2020 Bowman L, Baras A, Bombien R, Califf RM, Chen Z, Gale CP, Gaziano JM, Grobbee DE, Maggioni AP, Muse ED, Roden DM, Schroeder S, Wallentin L, Casadei B. Understanding the use of observational and randomized data in cardiovascular medicine. European Heart Journal. PMID 32016367 DOI: 10.1093/eurheartj/ehaa020  0.201
2018 Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, ... ... Roden DM, et al. Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC). American Heart Journal. 198: 152-159. PMID 29653637 DOI: 10.1016/J.Ahj.2017.12.010  0.201
2012 Delaney JT, Jeff JM, Brown NJ, Pretorius M, Okafor HE, Darbar D, Roden DM, Crawford DC. Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans. Plos One. 7: e32338. PMID 22384221 DOI: 10.1371/journal.pone.0032338  0.201
2019 Wise AL, Manolio TA, Mensah GA, Peterson JF, Roden DM, Tamburro C, Williams MS, Green ED. Genomic medicine for undiagnosed diseases. Lancet (London, England). PMID 31395441 DOI: 10.1016/S0140-6736(19)31274-7  0.201
2007 Yang P, Koopmann TT, Pfeufer A, Jalilzadeh S, Schulze-Bahr E, Kääb S, Wilde AA, Roden DM, Bezzina CR. Polymorphisms in the cardiac sodium channel promoter displaying variant in vitro expression activity. European Journal of Human Genetics : Ejhg. 16: 350-7. PMID 18059420 DOI: 10.1038/sj.ejhg.5201952  0.201
2011 Roden DM, Johnson JA, Kimmel SE, Krauss RM, Medina MW, Shuldiner A, Wilke RA. Cardiovascular pharmacogenomics. Circulation Research. 109: 807-20. PMID 21921273 DOI: 10.1161/CIRCRESAHA.110.230995  0.2
2011 Roden DM, Wilke RA, Kroemer HK, Stein CM. Pharmacogenomics: the genetics of variable drug responses. Circulation. 123: 1661-70. PMID 21502584 DOI: 10.1161/Circulationaha.109.914820  0.2
2018 Salem JE, Weintraub X, Courtillot C, Schaffer C, Gandjbakhch E, Maupain C, Moslehi D, Gougis P, Fressard V, Glaser A, Hidden-Lucet F, Touraine P, Vignes BL, Roden D, Bachelot A, et al. L’hypogonadisme peut être un facteur de risque de torsade de pointes chez l’homme Annales D Endocrinologie. 79: 237. DOI: 10.1016/J.Ando.2018.06.122  0.2
2011 Pendergrass S, Dudek SM, Roden DM, Crawford DC, Ritchie MD. Visual integration of results from a large DNA biobank (BioVU) using synthesis-view. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 265-75. PMID 21121054  0.2
2022 Leppig KA, Kulchak Rahm A, Appelbaum P, Aufox S, Bland ST, Buchanan A, Christensen KD, Chung WK, Clayton EW, Crosslin D, Denny J, DeVange S, Gordon A, Green RC, Hakonarson H, ... ... Roden DM, et al. The reckoning: The return of genomic results to 1444 participants across the eMERGE3 Network. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 35216901 DOI: 10.1016/j.gim.2022.01.015  0.199
2014 Delaney JT, Muhammad R, Shi Y, Schildcrout JS, Blair M, Short L, Roden DM, Darbar D. Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 16: 485-90. PMID 24072447 DOI: 10.1093/Europace/Eut278  0.198
2014 Kolek MJ, Edwards TL, Muhammad R, Balouch A, Shoemaker MB, Blair MA, Kor KC, Takahashi A, Kubo M, Roden DM, Tanaka T, Darbar D. A genome-wide association study to identify genomic modulators of rate control therapy in patients with atrial fibrillation. The American Journal of Cardiology. 114: 593-600. PMID 25015694 DOI: 10.1016/j.amjcard.2014.05.040  0.198
2009 Raj SR, Stein CM, Saavedra PJ, Roden DM. Cardiovascular effects of noncardiovascular drugs. Circulation. 120: 1123-32. PMID 19770411 DOI: 10.1161/Circulationaha.107.728576  0.198
2012 Wells QS, Delaney JT, Roden DM. Genetic determinants of response to cardiovascular drugs. Current Opinion in Cardiology. 27: 253-61. PMID 22382501 DOI: 10.1097/HCO.0b013e32835220e3  0.198
2013 Müller II, Melville DB, Tanwar V, Rybski WM, Mukherjee A, Shoemaker MB, Wang WD, Schoenhard JA, Roden DM, Darbar D, Knapik EW, Hatzopoulos AK. Functional modeling in zebrafish demonstrates that the atrial-fibrillation- associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm Dmm Disease Models and Mechanisms. 6: 332-341. PMID 23223679 DOI: 10.1242/Dmm.010488  0.197
2015 Kolek MJ, Muehlschlegel JD, Bush WS, Parvez B, Murray KT, Stein CM, Shoemaker MB, Blair MA, Kor KC, Roden DM, Donahue BS, Fox AA, Shernan SK, Collard CD, Body SC, et al. Genetic and clinical risk prediction model for postoperative atrial fibrillation. Circulation. Arrhythmia and Electrophysiology. 8: 25-31. PMID 25567478 DOI: 10.1161/Circep.114.002300  0.197
2018 Büttner P, Ueberham L, Shoemaker MB, Roden DM, Dinov B, Hindricks G, Bollmann A, Husser D. Identification of Central Regulators of Calcium Signaling and ECM-Receptor Interaction Genetically Associated With the Progression and Recurrence of Atrial Fibrillation. Frontiers in Genetics. 9: 162. PMID 29868113 DOI: 10.3389/fgene.2018.00162  0.197
2023 Dikilitas O, Sherafati A, Saadatagah S, Satterfield BA, Kochan DC, Anderson KC, Chung WK, Hebbring SJ, Salvati ZM, Sharp RR, Sturm AC, Gibbs RA, Rowley R, Venner E, Linder JE, ... ... Roden DM, et al. Familial Hypercholesterolemia in the Electronic Medical Records and Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, and Outcomes After Return of Results. Circulation. Genomic and Precision Medicine. 16: e003816. PMID 37071725 DOI: 10.1161/CIRCGEN.122.003816  0.197
2022 O'Neill MJ, Sala L, Denjoy I, Wada Y, Kozek K, Crotti L, Dagradi F, Kotta MC, Spazzolini C, Leenhardt A, Salem JE, Kashiwa A, Ohno S, Tao R, Roden DM, et al. Continuous Bayesian Variant Interpretation Accounts for Incomplete Penetrance among Mendelian Cardiac Channelopathies. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 36496179 DOI: 10.1016/j.gim.2022.12.002  0.196
2023 Zhang S, Strayer N, Vessels T, Choi K, Wang GW, Li Y, Bejan CA, Hsi RS, Bick AG, Velez Edwards DR, Savona MR, Philips EJ, Pulley J, Self WH, Hopkins WC, ... Roden DM, et al. PheMIME: An Interactive Web App and Knowledge Base for Phenome-Wide, Multi-Institutional Multimorbidity Analysis. Medrxiv : the Preprint Server For Health Sciences. PMID 37547012 DOI: 10.1101/2023.07.23.23293047  0.195
2015 Kolder IC, Tanck MW, Postema PG, Barc J, Sinner MF, Zumhagen S, Husemann A, Stallmeyer B, Koopmann TT, Hofman N, Pfeufer A, Lichtner P, Meitinger T, Beckmann BM, Myerburg RJ, ... ... Roden DM, et al. Analysis for Genetic Modifiers of Disease Severity in Patients With Long-QT Syndrome Type 2. Circulation. Cardiovascular Genetics. 8: 447-56. PMID 25737393 DOI: 10.1161/Circgenetics.114.000785  0.195
2022 Wiley K, Findley L, Goldrich M, Rakhra-Burris TK, Stevens A, Williams P, Bult CJ, Chisholm R, Deverka P, Ginsburg GS, Green ED, Jarvik G, Mensah GA, Ramos E, Relling MV, ... Roden DM, et al. A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources. Journal of the American Medical Informatics Association : Jamia. PMID 35485600 DOI: 10.1093/jamia/ocac057  0.194
2002 Roden DM, George AL. The genetic basis of variability in drug responses. Nature Reviews. Drug Discovery. 1: 37-44. PMID 12119608 DOI: 10.1038/nrd705  0.194
2015 Manolio TA, Abramowicz M, Al-Mulla F, Anderson W, Balling R, Berger AC, Bleyl S, Chakravarti A, Chantratita W, Chisholm RL, W Dissanayake VH, Dunn M, Dzau VJ, Han BG, Hubbard T, ... ... Roden DM, et al. Global implementation of genomic medicine: We are not alone. Science Translational Medicine. 7: 290ps13. PMID 26041702 DOI: 10.1126/Scitranslmed.Aab0194  0.194
2001 Roden DM. Pharmacogenetics and drug-induced arrhythmias. Cardiovascular Research. 50: 224-31. PMID 11334826 DOI: 10.1016/S0008-6363(00)00302-3  0.192
2013 Weeke P, Delaney J, Mosley JD, Wells Q, Van Driest S, Norris K, Kucera G, Stubblefield T, Roden DM. QT variability during initial exposure to sotalol: experience based on a large electronic medical record. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 15: 1791-7. PMID 23787903 DOI: 10.1093/europace/eut153  0.192
2023 Lancaster MC, Chen HH, Shoemaker MB, Fleming MR, Baker JT, Polikowsky HG, Samuels DC, Huff CD, Roden DM, Below JE. Detection of distant familial relatedness in biobanks for identification of undiagnosed carriers of a Mendelian disease variant: application to Long QT syndrome. Medrxiv : the Preprint Server For Health Sciences. PMID 37163006 DOI: 10.1101/2023.04.19.23288831  0.192
2022 Meester JAN, Peeters S, Van Den Heuvel L, Vandeweyer G, Fransen E, Cappella E, Dietz HC, Forbus G, Gelb BD, Goldmuntz E, Hoskoppal A, Landstrom AP, Lee T, Mital S, Morris S, ... ... Roden DM, et al. Molecular characterization and investigation of the role of genetic variation in phenotypic variability and response to treatment in a large pediatric Marfan syndrome cohort. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 35058154 DOI: 10.1016/j.gim.2021.12.015  0.192
2024 Davogustto G, Zhao S, Li Y, Farber-Eger E, Lowery BD, Shaffer LL, Mosley JD, Shoemaker MB, Xu Y, Roden DM, Wells QS. Unbiased characterization of atrial fibrillation phenotypic architecture provides insight to genetic liability and clinically relevant outcomes. Medrxiv : the Preprint Server For Health Sciences. PMID 38405916 DOI: 10.1101/2024.02.13.24302788  0.192
2017 Husser D, Ueberham L, Hindricks G, Büttner P, Ingram C, Weeke P, Shoemaker MB, Adams V, Arya A, Sommer P, Darbar D, Roden DM, Bollmann A. Rare variants in genes encoding the cardiac sodium channel and associated compounds and their impact on outcome of catheter ablation of atrial fibrillation. Plos One. 12: e0183690. PMID 28837624 DOI: 10.1371/journal.pone.0183690  0.192
2008 Darbar D, Kimbrough J, Jawaid A, McCray R, Ritchie MD, Roden DM. Persistent atrial fibrillation is associated with reduced risk of torsades de pointes in patients with drug-induced long QT syndrome. Journal of the American College of Cardiology. 51: 836-42. PMID 18294569 DOI: 10.1016/J.Jacc.2007.09.066  0.191
2012 Kääb S, Crawford DC, Sinner MF, Behr ER, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Guicheney P, Bishopric NH, Myerburg RJ, Schott JJ, Pfeufer A, Beckmann BM, Martens E, ... ... Roden DM, et al. A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circulation. Cardiovascular Genetics. 5: 91-9. PMID 22100668 DOI: 10.1161/Circgenetics.111.960930  0.19
2009 Husser D, Stridh M, Sörnmo L, Roden DM, Darbar D, Bollmann A. A genotype-dependent intermediate ECG phenotype in patients with persistent lone atrial fibrillation genotype ECG-phenotype correlation in atrial fibrillation. Circulation. Arrhythmia and Electrophysiology. 2: 24-8. PMID 19305639 DOI: 10.1161/CIRCEP.108.799098  0.19
2003 Kupershmidt S, Yang IC, Hayashi K, Wei J, Chanthaphaychith S, Petersen CI, Johns DC, George AL, Roden DM, Balser JR. The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 2263-5. PMID 14525949 DOI: 10.1096/Fj.02-1057Fje  0.19
2024 Yan C, Grabowska ME, Dickson AL, Li B, Wen Z, Roden DM, Michael Stein C, Embí PJ, Peterson JF, Feng Q, Malin BA, Wei WQ. Leveraging generative AI to prioritize drug repurposing candidates for Alzheimer's disease with real-world clinical validation. Npj Digital Medicine. 7: 46. PMID 38409350 DOI: 10.1038/s41746-024-01038-3  0.19
2016 Stroud DM, Yang T, Bersell K, Kryshtal DO, Nagao S, Shaffer C, Short L, Hall L, Atack TC, Zhang W, Knollmann BC, Baudenbacher F, Roden DM. Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart. Journal of the American Heart Association. 5. PMID 27806966 DOI: 10.1161/Jaha.115.002946  0.189
2008 Knollmann BC, Roden DM. A genetic framework for improving arrhythmia therapy. Nature. 451: 929-36. PMID 18288182 DOI: 10.1038/nature06799  0.189
2010 Bezzina CR, Pazoki R, Bardai A, Marsman RF, de Jong JS, Blom MT, Scicluna BP, Jukema JW, Bindraban NR, Lichtner P, Pfeufer A, Bishopric NH, Roden DM, Meitinger T, Chugh SS, et al. Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction. Nature Genetics. 42: 688-91. PMID 20622880 DOI: 10.1038/Ng.623  0.188
2014 Roden DM. Personalized medicine to treat arrhythmias. Current Opinion in Pharmacology. 15: 61-7. PMID 24721655 DOI: 10.1016/j.coph.2013.11.013  0.188
2020 Giudicessi JR, Roden DM, Wilde AAM, Ackerman MJ. Genetic Susceptibility for COVID-19-Associated Sudden Cardiac Death in African Americans. Heart Rhythm. PMID 32380288 DOI: 10.1016/j.hrthm.2020.04.045  0.187
2008 Darbar D, Kannankeril PJ, Donahue BS, Kucera G, Stubblefield T, Haines JL, George AL, Roden DM. Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation. 117: 1927-35. PMID 18378609 DOI: 10.1161/CIRCULATIONAHA.107.757955  0.187
2009 Bush WS, Crawford DC, Alexander C, George AL, Roden DM, Ritchie MD. Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Pharmacogenomics. 10: 1043-53. PMID 19530973 DOI: 10.2217/Pgs.09.67  0.185
2012 Jamshidi Y, Nolte IM, Dalageorgou C, Zheng D, Johnson T, Bastiaenen R, Ruddy S, Talbott D, Norris KJ, Snieder H, George AL, Marshall V, Shakir S, Kannankeril PJ, Munroe PB, ... ... Roden DM, et al. Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia. Journal of the American College of Cardiology. 60: 841-50. PMID 22682551 DOI: 10.1016/j.jacc.2012.03.031  0.185
2016 Roden DM. Predicting drug-induced QT prolongation and torsades de pointes. The Journal of Physiology. 594: 2459-68. PMID 26660066 DOI: 10.1113/JP270526  0.185
2013 Peterson JF, Bowton E, Field JR, Beller M, Mitchell J, Schildcrout J, Gregg W, Johnson K, Jirjis JN, Roden DM, Pulley JM, Denny JC. Electronic health record design and implementation for pharmacogenomics: a local perspective. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 15: 833-41. PMID 24009000 DOI: 10.1038/Gim.2013.109  0.184
2017 Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, Kanoni S, Nelson CP, Ferrario PG, König IR, Eicher JD, Johnson AD, Hamby SE, Betsholtz C, Ruusalepp A, ... ... Roden DM, et al. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Journal of the American College of Cardiology. 69: 823-836. PMID 28209224 DOI: 10.1016/J.Jacc.2016.11.056  0.184
2008 Wilke RA, Lin DW, Roden DM, Watkins PB, Flockhart D, Zineh I, Giacomini KM, Krauss RM. Erratum: Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges Nature Reviews Drug Discovery. 7: 185-185. DOI: 10.1038/nrd2508  0.184
2007 Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, ... ... Roden DM, et al. The pharmacogenetics research network: from SNP discovery to clinical drug response. Clinical Pharmacology and Therapeutics. 81: 328-45. PMID 17339863 DOI: 10.1038/Sj.Clpt.6100087  0.183
2019 Kroncke BM, Yang T, Roden DM. Multiple mechanisms underlie increased cardiac late sodium current. Heart Rhythm. PMID 30677491 DOI: 10.1016/J.Hrthm.2019.01.018  0.182
2011 McCarty CA, Chisholm RL, Chute CG, Kullo IJ, Jarvik GP, Larson EB, Li R, Masys DR, Ritchie MD, Roden DM, Struewing JP, Wolf WA. The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. Bmc Medical Genomics. 4: 13. PMID 21269473 DOI: 10.1186/1755-8794-4-13  0.182
2014 Savio-Galimberti E, Weeke P, Muhammad R, Blair M, Ansari S, Short L, Atack TC, Kor K, Vanoye CG, Olesen MS, LuCamp, Yang T, George AL, Roden DM, Darbar D. SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation. Cardiovascular Research. 104: 355-63. PMID 25053638 DOI: 10.1093/cvr/cvu170  0.182
2005 Brink PA, Crotti L, Corfield V, Goosen A, Durrheim G, Hedley P, Heradien M, Geldenhuys G, Vanoli E, Bacchini S, Spazzolini C, Lundquist AL, Roden DM, George AL, Schwartz PJ. Phenotypic variability and unusual clinical severity of congenital long-QT syndrome in a founder population. Circulation. 112: 2602-10. PMID 16246960 DOI: 10.1161/Circulationaha.105.572453  0.181
2024 Puckelwartz MJ, Pesce LL, Hernandez EJ, Webster G, Dellefave-Castillo LM, Russell MW, Geisler SS, Kearns SD, Karthik F, Etheridge SP, Monroe TO, Pottinger TD, Kannankeril PJ, Shoemaker MB, Fountain D, ... Roden DM, et al. The impact of damaging epilepsy and cardiac genetic variant burden in sudden death in the young. Genome Medicine. 16: 13. PMID 38229148 DOI: 10.1186/s13073-024-01284-w  0.181
2023 Puckelwartz MJ, Pesce LL, Hernandez EJ, Webster G, Dellefave-Castillo LM, Russell MW, Geisler SS, Kearns SD, Etheridge FK, Etheridge SP, Monroe TO, Pottinger TD, Kannankeril PJ, Shoemaker MB, Fountain D, ... Roden DM, et al. The impact of damaging epilepsy and cardiac genetic variant burden in sudden death in the young. Medrxiv : the Preprint Server For Health Sciences. PMID 37034657 DOI: 10.1101/2023.03.27.23287711  0.181
1986 Roden DM, Woosley RL, Primm RK. Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care. American Heart Journal. 111: 1088-93. PMID 3716982 DOI: 10.1016/0002-8703(86)90010-4  0.179
2006 McCray R, Ritchie MD, Roden DM, Darbar D. P1-22: Persistent atrial fibrillation is associated with reduced risk of Torsades de Pointes in patients with drug-induced long QT syndrome Heart Rhythm. 3. DOI: 10.1016/J.Hrthm.2006.02.345  0.179
2013 Ramirez AH, Shaffer CM, Delaney JT, Sexton DP, Levy SE, Rieder MJ, Nickerson DA, George AL, Roden DM. Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes Pharmacogenomics Journal. 13: 325-329. DOI: 10.1038/tpj.2012.14  0.178
1987 Roden DM, Iansmith DH. Effects of low potassium or magnesium concentrations on isolated cardiac tissue. The American Journal of Medicine. 82: 18-23. PMID 3565423 DOI: 10.1016/0002-9343(87)90128-8  0.178
2016 Van Driest SL, Wells QS, Roden DM. Long QT Syndrome and Potentially Pathogenic Genetic Variants--In Reply. Jama. 315: 2467-8. PMID 27299624 DOI: 10.1001/jama.2016.2921  0.178
2018 Aragam KG, Chaffin M, Levinson RT, McDermott G, Choi SH, Shoemaker MB, Haas ME, Weng LC, Lindsay ME, Smith JG, Newton-Cheh C, Roden DM, London B, Wells QS, Ellinor PT, et al. Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery. Circulation. PMID 30586722 DOI: 10.1161/Circulationaha.118.035774  0.178
2011 Holm H, Gudbjartsson DF, Sulem P, Masson G, Helgadottir HT, Zanon C, Magnusson OT, Helgason A, Saemundsdottir J, Gylfason A, Stefansdottir H, Gretarsdottir S, Matthiasson SE, Thorgeirsson GM, Jonasdottir A, ... ... Roden DM, et al. A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nature Genetics. 43: 316-20. PMID 21378987 DOI: 10.1038/ng.781  0.177
2020 Van Driest SL, Sleeper LA, Gelb BD, Morris SA, Dietz HC, Forbus GA, Goldmuntz E, Hoskoppal A, James J, Lee TM, Levine JC, Li JS, Loeys BL, Markham LW, Meester JAN, ... ... Roden DM, et al. Variants in ADRB1 and CYP2C9: Association with Response to Atenolol and Losartan in Marfan Syndrome. The Journal of Pediatrics. 222: 213-220.e5. PMID 32586526 DOI: 10.1016/J.Jpeds.2020.03.064  0.177
2017 Lee HJ, Jiang M, Wu Y, Shaffer CM, Cleator JH, Friedman EA, Lewis JP, Roden DM, Denny J, Xu H. A comparative study of different methods for automatic identification of clopidogrel-induced bleedings in electronic health records. Amia Joint Summits On Translational Science Proceedings. Amia Joint Summits On Translational Science. 2017: 185-192. PMID 28815128  0.177
2022 Gray B, Baruteau AE, Antolin AA, Pittman A, Sarganas G, Molokhia M, Blom MT, Bastiaenen R, Bardai A, Priori SG, Napolitano C, Weeke PE, Shakir SA, Haverkamp W, Mestres J, ... ... Roden DM, et al. Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome. Circulation. Genomic and Precision Medicine. CIRCGEN121003391. PMID 35113648 DOI: 10.1161/CIRCGEN.121.003391  0.177
1999 Priori SG, Barhanin J, Hauer RN, Haverkamp W, Jongsma HJ, Kleber AG, McKenna WJ, Roden DM, Rudy Y, Schwartz K, Schwartz PJ, Towbin JA, Wilde AM. Genetic and molecular basis of cardiac arrhythmias: impact on clinical management part III. Circulation. 99: 674-81. PMID 9950666 DOI: 10.1161/01.Cir.99.5.674  0.176
2013 Curtis MJ, Hancox JC, Farkas A, Wainwright CL, Stables CL, Saint DA, Clements-Jewery H, Lambiase PD, Billman GE, Janse MJ, Pugsley MK, Ng GA, Roden DM, Camm AJ, Walker MJ. The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacology & Therapeutics. 139: 213-48. PMID 23588158 DOI: 10.1016/j.pharmthera.2013.04.008  0.176
2010 Fishman GI, Chugh SS, Dimarco JP, Albert CM, Anderson ME, Bonow RO, Buxton AE, Chen PS, Estes M, Jouven X, Kwong R, Lathrop DA, Mascette AM, Nerbonne JM, O'Rourke B, ... ... Roden DM, et al. Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Circulation. 122: 2335-48. PMID 21147730 DOI: 10.1161/Circulationaha.110.976092  0.176
2009 Watanabe H, Kaiser DW, Makino S, MacRae CA, Ellinor PT, Wasserman BS, Kannankeril PJ, Donahue BS, Roden DM, Darbar D. ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 6: 1327-32. PMID 19648063 DOI: 10.1016/J.Hrthm.2009.05.014  0.176
2002 Kanki H, Yang P, Xie HG, Kim RB, George AL, Roden DM. Polymorphisms in beta-adrenergic receptor genes in the acquired long QT syndrome. Journal of Cardiovascular Electrophysiology. 13: 252-6. PMID 11942593 DOI: 10.1046/j.1540-8167.2002.00252.x  0.176
2021 Kertai MD, Mosley JD, He J, Ramakrishnan A, Abdelmalak M, Hong Y, Shoemaker MB, Roden DM, Bastarache L. Predictive Accuracy of a Polygenic Risk Score for Postoperative Atrial Fibrillation After Cardiac Surgery. Circulation. Genomic and Precision Medicine. PMID 33647223 DOI: 10.1161/CIRCGEN.120.003269  0.175
2012 Grace AA, Roden DM. Systems biology and cardiac arrhythmias. Lancet. 380: 1498-508. PMID 23101717 DOI: 10.1016/S0140-6736(12)61462-7  0.175
2000 Roden DM, Spooner PM. Inherited long QT syndromes: a paradigm for understanding arrhythmogenesis. Journal of Cardiovascular Electrophysiology. 10: 1664-83. PMID 10636197 DOI: 10.1111/j.1540-8167.1999.tb00231.x  0.175
2005 Kannankeril PJ, Roden DM, Norris KJ, Whalen SP, George AL, Murray KT. Genetic susceptibility to acquired long QT syndrome: Pharmacologic challenge in first-degree relatives Heart Rhythm. 2: 134-140. PMID 15851285 DOI: 10.1016/J.Hrthm.2004.10.039  0.174
2012 Makita N, Seki A, Sumitomo N, Chkourko H, Fukuhara S, Watanabe H, Shimizu W, Bezzina CR, Hasdemir C, Mugishima H, Makiyama T, Baruteau A, Baron E, Horie M, Hagiwara N, ... ... Roden DM, et al. A connexin40 mutation associated with a malignant variant of progressive familial heart block type I. Circulation. Arrhythmia and Electrophysiology. 5: 163-72. PMID 22247482 DOI: 10.1161/CIRCEP.111.967604  0.174
2009 Klein TE, Altman RB, Eriksson N, Gage BF, Kimmel SE, Lee MT, Limdi NA, Page D, Roden DM, Wagner MJ, Caldwell MD, Johnson JA. Estimation of the warfarin dose with clinical and pharmacogenetic data. The New England Journal of Medicine. 360: 753-64. PMID 19228618 DOI: 10.1056/NEJMoa0809329  0.173
2012 Savio Galimberti E, Vanoye C, Yang T, Atack T, Muhammad R, Roden D, Darbar D. SCN10A Rare Variants Associated with Atrial Fibrillation and Slow Ventricular Rates Reveal Increased Late Sodium Current Heart Rhythm. 9: 1911. DOI: 10.1016/J.HRTHM.2012.09.095  0.173
2010 Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Circulation. 121: 1047-60. PMID 20142454 DOI: 10.1161/Circulationaha.109.192704  0.172
1999 Wei J, Wang DW, Alings M, Fish F, Wathen M, Roden DM, George AL. Congenital long-QT syndrome caused by a novel mutation in a conserved acidic domain of the cardiac Na+ channel. Circulation. 99: 3165-71. PMID 10377081 DOI: 10.1161/01.CIR.99.24.3165  0.172
2005 Darbar D, Hardy A, Ritchie MD, Gainer J, Roden DM. ACE I/D polymorphism modulates response to antiarrhythmic drug therapy in patients with atrial fibrillation Heart Rhythm. 2: S67. DOI: 10.1016/J.Hrthm.2005.02.212  0.171
2008 Watanabe H, Koopmann TT, Scouarnec SL, Yang T, Ingram CR, Schott J, Demolombe S, Probst V, Anselme F, Escande D, Wiesfeld ACP, Pfeufer A, Kääb S, Wichmann H-, Hasdemir C, ... ... Roden DM, et al. Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans Journal of Clinical Investigation. 118: 2260-2268. PMID 18464934 DOI: 10.1172/Jci33891  0.171
2003 Johnson WH, Yang P, Yang T, Lau YR, Mostella BA, Wolff DJ, Roden DM, Benson DW. Clinical, genetic, and biophysical characterization of a homozygous HERG mutation causing severe neonatal long QT syndrome. Pediatric Research. 53: 744-8. PMID 12621127 DOI: 10.1203/01.PDR.0000059750.17002.B6  0.17
2009 Kääb S, Darbar D, van Noord C, Dupuis J, Pfeufer A, Newton-Cheh C, Schnabel R, Makino S, Sinner MF, Kannankeril PJ, Beckmann BM, Choudry S, Donahue BS, Heeringa J, Perz S, ... ... Roden DM, et al. Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. European Heart Journal. 30: 813-9. PMID 19141561 DOI: 10.1093/Eurheartj/Ehn578  0.17
2010 Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Journal of the American College of Cardiology. 55: 934-47. PMID 20185054 DOI: 10.1016/J.Jacc.2010.01.001  0.169
2003 Laohakunakorn P, Benson DW, Yang P, Yang T, Roden DM, Kugler JD. Bidirectional ventricular tachycardia and channelopathy. The American Journal of Cardiology. 92: 991-5. PMID 14556882 DOI: 10.1016/S0002-9149(03)00987-1  0.169
2005 Simard C, Drolet B, Yang P, Kim RB, Roden DM. Polymorphism screening in the cardiac K+ channel gene KCNA5. Clinical Pharmacology and Therapeutics. 77: 138-44. PMID 15735608 DOI: 10.1016/j.clpt.2004.10.008  0.169
1999 Roden DM, Wilde AA. Drug-induced J point elevation: a marker for genetic risk of sudden death or ECG curiosity? Journal of Cardiovascular Electrophysiology. 10: 219-23. PMID 10090225 DOI: 10.1111/j.1540-8167.1999.tb00663.x  0.168
2023 Weinstock JS, Laurie CA, Broome JG, Taylor KD, Guo X, Shuldiner AR, O'Connell JR, Lewis JP, Boerwinkle E, Barnes KC, Chami N, Kenny EE, Loos RJF, Fornage M, Redline S, ... ... Roden D, et al. The genetic determinants of recurrent somatic mutations in 43,693 blood genomes. Science Advances. 9: eabm4945. PMID 37126548 DOI: 10.1126/sciadv.abm4945  0.167
2017 Roden DM. Reprint of Editiorial Commentary: Genomics and drug discovery: The next frontier in precision medicine. Trends in Cardiovascular Medicine. PMID 28601251 DOI: 10.1016/j.tcm.2017.05.008  0.167
2018 Mosley JD, Levinson RT, Brittain EL, Gupta DK, Farber-Eger E, Shaffer CM, Denny JC, Roden DM, Wells QS. Clinical Features Associated With Nascent Left Ventricular Diastolic Dysfunction in a Population Aged 40 to 55 Years. The American Journal of Cardiology. PMID 29627106 DOI: 10.1016/j.amjcard.2018.02.042  0.166
2007 Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, Nakamura Y. When good drugs go bad. Nature. 446: 975-7. PMID 17460642 DOI: 10.1038/446975A  0.166
2020 Nguyen LS, Dolladille C, Drici MD, Fenioux C, Alexandre J, Mira JP, Moslehi JJ, Roden DM, Funck-Brentano C, Salem JE. Cardiovascular Toxicities Associated with Hydroxychloroquine and Azithromycin: An Analysis of the World Health Organization Pharmacovigilance Database. Circulation. PMID 32442023 DOI: 10.1161/CIRCULATIONAHA.120.048238  0.166
2017 Roden DM. Phenome-wide association studies: A new method for functional genomics in humans. The Journal of Physiology. PMID 28229460 DOI: 10.1113/JP273122  0.166
2016 Roden DM. Editiorial Commentary: Genomics and drug discovery: The next frontier in precision medicine. Trends in Cardiovascular Medicine. PMID 27771237 DOI: 10.1016/j.tcm.2016.09.004  0.166
2008 Schwarz UI, Ritchie MD, Bradford Y, Li C, Dudek SM, Frye-Anderson A, Kim RB, Roden DM, Stein CM. Genetic determinants of response to warfarin during initial anticoagulation. The New England Journal of Medicine. 358: 999-1008. PMID 18322281 DOI: 10.1056/Nejmoa0708078  0.166
2019 Kroncke BM, Mendenhall J, Smith DK, Sanders CR, Capra JA, George AL, Blume JD, Meiler J, Roden DM. Protein structure aids predicting functional perturbation of missense variants in and . Computational and Structural Biotechnology Journal. 17: 206-214. PMID 30828412 DOI: 10.1016/J.Csbj.2019.01.008  0.166
2006 Zipes DP, Camm AJ, Borggrefe M, Buxton AE, Chaitman B, Fromer M, Gregoratos G, Klein G, Moss AJ, Myerburg RJ, Priori SG, Quinones MA, Roden DM, Silka MJ, Tracy C, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 8: 746-837. PMID 16935866 DOI: 10.1093/Europace/Eul108  0.166
2008 Roden DM. Cellular basis of drug-induced torsades de pointes. British Journal of Pharmacology. 154: 1502-7. PMID 18552874 DOI: 10.1038/bjp.2008.238  0.166
2004 Roden DM. Genetic polymorphisms, drugs, and proarrhythmia. Journal of Interventional Cardiac Electrophysiology : An International Journal of Arrhythmias and Pacing. 9: 131-5. PMID 14574023 DOI: 10.1023/A:1026267903800  0.166
2002 Roden DM, Balser JR, George AL, Anderson ME. Cardiac ion channels. Annual Review of Physiology. 64: 431-75. PMID 11826275 DOI: 10.1146/Annurev.Physiol.64.083101.145105  0.166
2019 Lewis JP, Backman JD, Reny JL, Bergmeijer TO, Mitchell BD, Ritchie MD, Déry JP, Pakyz RE, Gong L, Ryan K, Kim EY, Aradi D, Fernandez-Cadenas I, Lee MTM, Whaley RM, ... ... Roden DM, et al. Pharmacogenomic Polygenic Response Score Predicts Ischemic Events and Cardiovascular Mortality in Clopidogrel-Treated Patients. European Heart Journal. Cardiovascular Pharmacotherapy. PMID 31504375 DOI: 10.1093/Ehjcvp/Pvz045  0.165
2023 Virk ZM, Richardson TL, Nowatzke JF, Ullah A, Pedrotty DM, Shoemaker MB, Kanagasundram A, Roden DM, Stevenson WG. Cardiac Sarcoidosis and a Likely Pathogenic Variant in a Patient Presenting With Ventricular Tachycardia. Jacc. Case Reports. 16: 101878. PMID 37396334 DOI: 10.1016/j.jaccas.2023.101878  0.165
2008 Rhodes TE, Abraham RL, Welch RC, Vanoye CG, Crotti L, Arnestad M, Insolia R, Pedrazzini M, Ferrandi C, Vege A, Rognum T, Roden DM, Schwartz PJ, George AL. Cardiac potassium channel dysfunction in sudden infant death syndrome. Journal of Molecular and Cellular Cardiology. 44: 571-81. PMID 18222468 DOI: 10.1016/J.Yjmcc.2007.11.015  0.165
2015 Peterson JF, Field JR, Unertl K, Schildcrout JS, Johnson DC, Shi Y, Danciu I, Cleator JH, Pulley JM, McPherson JA, Denny JC, Laposata M, Roden DM, Johnson KB. Physician response to implementation of genotype-tailored antiplatelet therapy. Clinical Pharmacology and Therapeutics. PMID 26693963 DOI: 10.1002/Cpt.331  0.164
2001 Yang T, Snyders D, Roden DM. Drug block of I(kr): model systems and relevance to human arrhythmias. Journal of Cardiovascular Pharmacology. 38: 737-44. PMID 11602820 DOI: 10.1097/00005344-200111000-00010  0.164
2013 Parvez B, Shoemaker MB, Muhammad R, Richardson R, Jiang L, Blair MA, Roden DM, Darbar D. Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 10: 849-55. PMID 23428961 DOI: 10.1016/j.hrthm.2013.02.018  0.164
2015 Shoemaker MB, Bollmann A, Lubitz SA, Ueberham L, Saini H, Montgomery J, Edwards T, Yoneda Z, Sinner MF, Arya A, Sommer P, Delaney J, Goyal SK, Saavedra P, Kanagasundram A, ... ... Roden DM, et al. Common genetic variants and response to atrial fibrillation ablation. Circulation. Arrhythmia and Electrophysiology. 8: 296-302. PMID 25684755 DOI: 10.1161/Circep.114.001909  0.164
2006 Bezzina CR, Shimizu W, Yang P, Koopmann TT, Tanck MW, Miyamoto Y, Kamakura S, Roden DM, Wilde AA. Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction. Circulation. 113: 338-44. PMID 16415376 DOI: 10.1161/CIRCULATIONAHA.105.580811  0.164
2020 Mosley JD, Gupta DK, Tan J, Yao J, Wells QS, Shaffer CM, Kundu S, Robinson-Cohen C, Psaty BM, Rich SS, Post WS, Guo X, Rotter JI, Roden DM, Gerszten RE, et al. Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease. Jama. 323: 627-635. PMID 32068817 DOI: 10.1001/Jama.2019.21782  0.163
2011 Kannankeril PJ, Norris KJ, Carter S, Roden DM. Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers. Heart Rhythm. 8: 1530-4. PMID 21420510 DOI: 10.1016/j.hrthm.2011.03.042  0.163
2004 Fenichel RR, Malik M, Antzelevitch C, Sanguinetti M, Roden DM, Priori SG, Ruskin JN, Lipicky RJ, Cantilena LR. Drug-induced torsades de pointes and implications for drug development. Journal of Cardiovascular Electrophysiology. 15: 475-95. PMID 15090000 DOI: 10.1046/J.1540-8167.2004.03534.X  0.163
2021 Shi M, Manouchehri AM, Shaffer CM, Vaitinadin NS, Hellwege JN, Salem JE, Davis LK, Simmons JH, Roden DM, Shoemaker MB, Ferguson JF, Mosley JD. Genetic thyroid stimulating hormone regulation of atrial fibrillation risk is mediated through an effect on height. The Journal of Clinical Endocrinology and Metabolism. PMID 33895829 DOI: 10.1210/clinem/dgab272  0.162
2013 Roden DM, Tyndale RF. Genomic medicine, precision medicine, personalized medicine: what's in a name? Clinical Pharmacology and Therapeutics. 94: 169-72. PMID 23872826 DOI: 10.1038/clpt.2013.101  0.162
1996 Roden DM. Ionic mechanisms for prolongation of refractoriness and their proarrhythmic and antiarrhythmic correlates. The American Journal of Cardiology. 78: 12-6. PMID 8780324 DOI: 10.1016/S0002-9149(96)00448-1  0.162
2006 Darbar D, Roden DM. Pharmacogenetics of antiarrhythmic therapy. Expert Opinion On Pharmacotherapy. 7: 1583-90. PMID 16872261 DOI: 10.1517/14656566.7.12.1583  0.161
2009 Li C, Schwarz UI, Ritchie MD, Roden DM, Stein CM, Kurnik D. Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy. Blood. 113: 3925-30. PMID 19074728 DOI: 10.1182/Blood-2008-09-176859  0.161
2020 Davogustto GE, Farber-Eger E, MURRAY KT, Michaud GF, Shoemaker BB, Mosley J, Roden DM, Wells Q. Abstract 16179: Concordance Between Machine Learning-based Methods of Atrial Fibrillation Subtyping in 49,905 Individuals and Relationship to Genetically Predicted Af Risk and Inflammation Circulation. 142. DOI: 10.1161/CIRC.142.SUPPL_3.16179  0.161
2017 Kannankeril PJ, Moore JP, Cerrone M, Priori SG, Kertesz NJ, Ro PS, Batra AS, Kaufman ES, Fairbrother DL, Saarel EV, Etheridge SP, Kanter RJ, Carboni MP, Dzurik MV, Fountain D, ... ... Roden DM, et al. Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial. Jama Cardiology. PMID 28492868 DOI: 10.1001/jamacardio.2017.1320  0.161
2010 Wang DW, Gillani N, Roden DM, Darbar D, George AL. Sodium Channel Variants Associated with Atrial Fibrillation Exhibit Abnormal Fast and Slow Inactivation Biophysical Journal. 98: 310a. DOI: 10.1016/J.BPJ.2009.12.1687  0.16
2013 Manolio TA, Chisholm RL, Ozenberger B, Roden DM, Williams MS, Wilson R, Bick D, Bottinger EP, Brilliant MH, Eng C, Frazer KA, Korf B, Ledbetter DH, Lupski JR, Marsh C, et al. Implementing Genomic Medicine in the Clinic Obstetrical & Gynecological Survey. 68: 621-623. DOI: 10.1097/01.ogx.0000435523.89711.77  0.16
2021 Levinson RT, Vaitinidin NS, Farber-Eger E, Roden DM, Lasko TA, Wells QS, Mosley JD. Heart failure clinical care analysis uncovers risk reduction opportunities for preserved ejection fraction subtype. Scientific Reports. 11: 18618. PMID 34545125 DOI: 10.1038/s41598-021-97831-1  0.159
2017 Yang Z, Prinsen JK, Bersell KR, Shen W, Yermalitskaya L, Sidorova T, Luis PB, Hall L, Zhang W, Du L, Milne G, Tucker P, George AL, Campbell CM, Pickett RA, ... ... Roden DM, et al. Azithromycin Causes a Novel Proarrhythmic Syndrome. Circulation. Arrhythmia and Electrophysiology. 10. PMID 28408648 DOI: 10.1161/Circep.115.003560  0.159
1985 Roden DM, Woosley RL. QT prolongation and arrhythmia suppression. American Heart Journal. 109: 411-5. PMID 2578242 DOI: 10.1016/0002-8703(85)90627-1  0.159
2019 Wells QS, Gupta DK, Smith JG, Collins SP, Storrow AB, Ferguson J, Smith ML, Pulley JM, Collier S, Wang X, Roden DM, Gerszten RE, Wang TJ. Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics. Journal of the American College of Cardiology. 73: 2195-2205. PMID 31047008 DOI: 10.1016/j.jacc.2019.01.074  0.158
2015 Barrett TW, Storrow AB, Jenkins CA, Abraham RL, Liu D, Miller KF, Moser KM, Russ S, Roden DM, Harrell FE, Darbar D. The AFFORD clinical decision aid to identify emergency department patients with atrial fibrillation at low risk for 30-day adverse events. The American Journal of Cardiology. 115: 763-70. PMID 25633190 DOI: 10.1016/J.Amjcard.2014.12.036  0.158
2021 Yoneda ZT, Anderson KC, Estrada JC, Quintana JA, Strickland T, Montgomery JA, Michaud GF, Roden DM, Shoemaker MB. Genetic Testing for Early Onset Atrial Arrhythmias Changes Clinical Management: 2 Cases of Cardiac Emerinopathy. Jacc. Clinical Electrophysiology. PMID 33516708 DOI: 10.1016/j.jacep.2020.11.006  0.158
2023 El-Harasis MA, Yoneda ZT, Davogustto GE, Crawford DM, Laws JL, Frye B, Herrmann T, Patel B, Touchton SA, Roden DM, Richardson TD, Saavedra P, Shen ST, Estrada JC, Kanagasundram AN, et al. Pulmonary Vein Myocardial Sleeve Length and its Association With Sex and 4q25/PITX2 Genotype. Jacc. Clinical Electrophysiology. 9: 1147-1157. PMID 37495323 DOI: 10.1016/j.jacep.2022.12.028  0.158
2008 Makita N, Behr E, Shimizu W, Horie M, Sunami A, Crotti L, Schulze-Bahr E, Fukuhara S, Mochizuki N, Makiyama T, Itoh H, Christiansen M, McKeown P, Miyamoto K, Kamakura S, ... ... Roden DM, et al. The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. The Journal of Clinical Investigation. 118: 2219-29. PMID 18451998 DOI: 10.1172/Jci34057  0.157
1996 Roden DM, Lazzara R, Rosen M, Schwartz PJ, Towbin J, Vincent GM. Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS. Circulation. 94: 1996-2012. PMID 8873679 DOI: 10.1161/01.Cir.94.8.1996  0.157
2009 Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, Duff HJ, Roden DM, Wilde AA, Knollmann BC. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nature Medicine. 15: 380-3. PMID 19330009 DOI: 10.1038/nm.1942  0.157
1994 Roden DM. Current status of class III antiarrhythmic drug therapy. The American Journal of Cardiology. 72: 44B-49B. PMID 8256755 DOI: 10.1016/0002-9149(93)90040-J  0.156
2021 Prifti E, Fall A, Davogustto G, Pulini A, Denjoy I, Funck-Brentano C, Khan Y, Durand-Salmon A, Badilini F, Wells QS, Leenhardt A, Zucker JD, Roden DM, Extramiana F, Salem JE. Deep learning analysis of electrocardiogram for risk prediction of drug-induced arrhythmias and diagnosis of long QT syndrome. European Heart Journal. PMID 34468739 DOI: 10.1093/eurheartj/ehab588  0.156
2021 Rossow KM, Oshikoya KA, Aka IT, Maxwell-Horn AC, Roden DM, Van Driest SL. Evidence for Pharmacogenomic Effects on Risperidone Outcomes in Pediatrics. Journal of Developmental and Behavioral Pediatrics : Jdbp. 42: 205-212. PMID 33759847 DOI: 10.1097/DBP.0000000000000883  0.156
1984 Woosley RL, Cerskus I, Roden DM. Antiarrhythmic therapy: clinical pharmacology update. Journal of Clinical Pharmacology. 24: 295-305. PMID 6384277 DOI: 10.1002/j.1552-4604.1984.tb01838.x  0.155
1981 Roden DM, Duff HJ, Reele SB, Woosley RL, Oates JA, Smith RF, Friesinger GC. Recurrent ventricular tachycardia in the absence of overt heart disease: clinical characteristics and response to drug therapy. Southern Medical Journal. 74: 1090-4. PMID 7280757 DOI: 10.1097/00007611-198109000-00020  0.155
1999 Nattel S, Roden DM, Escande D. A spotlight on electrophysiological remodeling and the molecular biology of ion channels Cardiovascular Research. 42: 267-269. PMID 10533565 DOI: 10.1016/S0008-6363(99)00072-3  0.155
2018 Mosley JD, Benson MD, Smith JG, Melander O, Ngo D, Shaffer CM, Ferguson JF, Herzig MS, McCarty CA, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, ... ... Roden DM, et al. Probing the Virtual Proteome to Identify Novel Disease Biomarkers. Circulation. 138: 2469-2481. PMID 30571344 DOI: 10.1161/Circulationaha.118.036063  0.155
2022 Lee CR, Luzum JA, Sangkuhl K, Gammal RS, Sabatine MS, Stein CM, Kisor DF, Limdi NA, Lee YM, Scott SA, Hulot JS, Roden DM, Gaedigk A, Caudle KE, Klein TE, et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update. Clinical Pharmacology and Therapeutics. PMID 35034351 DOI: 10.1002/cpt.2526  0.154
2007 Darbar D, Motsinger AA, Ritchie MD, Gainer JV, Roden DM. Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation. Heart Rhythm. 4: 743-9. PMID 17556195 DOI: 10.1016/J.Hrthm.2007.02.006  0.154
1999 Vitola J, Vukanovic J, Roden DM. Cisapride-induced torsades de pointes. Journal of Cardiovascular Electrophysiology. 9: 1109-13. PMID 9817562 DOI: 10.1111/j.1540-8167.1998.tb00888.x  0.154
2017 Hill JA, Ardehali R, Clarke KT, Del Zoppo GJ, Eckhardt LL, Griendling KK, Libby P, Roden DM, Sadek HA, Seidman CE, Vaughan DE. Fundamental Cardiovascular Research: Returns on Societal Investment: A Scientific Statement From the American Heart Association. Circulation Research. PMID 28652256 DOI: 10.1161/Res.0000000000000155  0.154
1994 Roden DM. Early after-depolarizations and torsade de pointes: implications for the control of cardiac arrhythmias by prolonging repolarization. European Heart Journal. 56-61. PMID 8293755 DOI: 10.1093/EURHEARTJ/14.SUPPL_H.56  0.154
2010 Pulley J, Clayton E, Bernard GR, Roden DM, Masys DR. Principles of human subjects protections applied in an opt-out, de-identified biobank. Clinical and Translational Science. 3: 42-8. PMID 20443953 DOI: 10.1111/j.1752-8062.2010.00175.x  0.153
2023 Han L, Annis J, Master H, Hughes A, Roden D, Harris P, Ruderfer D, Brittain E. Quantifying physical activity needed to mitigate genetic risk for obesity. Research Square. PMID 37333237 DOI: 10.21203/rs.3.rs-2986582/v1  0.153
1984 Siddoway LA, Roden DM, Woosley RL. Clinical pharmacology of propafenone: pharmacokinetics, metabolism and concentration-response relations. The American Journal of Cardiology. 54: 9D-12D. PMID 6496371 DOI: 10.1016/S0002-9149(84)80278-7  0.153
2021 Kaufman ES, Eckhardt LL, Ackerman MJ, Aziz PF, Behr ER, Cerrone M, Chung MK, Cutler MJ, Etheridge SP, Krahn AD, Lubitz SA, Perez MV, Priori SG, Roberts JD, Roden DM, et al. Management of Congenital Long-QT Syndrome: Commentary From the Experts. Circulation. Arrhythmia and Electrophysiology. CIRCEP120009726. PMID 34238011 DOI: 10.1161/CIRCEP.120.009726  0.153
2019 Salem JE, Lebrun-Vignes B, Pariente A, Shaffer CM, Malouf GG, Dureau P, Potey C, Funck-Brentano C, Roden DM, Moslehi JJ, Bretagne M. P2597Heart failure and atrial tachyarrhythmia on abiraterone: a characterization using pharmacovigilance databases European Heart Journal. 40. DOI: 10.1093/eurheartj/ehz748.0922  0.152
1996 Roden DM, George AL, Bennett PB. Recent advances in understanding the molecular mechanisms of the long QT syndrome. Journal of Cardiovascular Electrophysiology. 6: 1023-31. PMID 8589871 DOI: 10.1111/j.1540-8167.1995.tb00379.x  0.152
1986 Roden DM, Thompson KA, Hoffman BF, Woosley RL. Clinical features and basic mechanisms of quinidine-induced arrhythmias Journal of the American College of Cardiology. 8. PMID 2423573 DOI: 10.1016/S0735-1097(86)80032-8  0.151
2023 Krogager ML, Skals RK, Appel EVR, Schnurr TM, Engelbrechtsen L, Have CT, Pedersen O, Engstrøm T, Roden DM, Gislason G, Poulsen HE, Køber L, Stender S, Hansen T, Grarup N, et al. Correction: Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography. Plos One. 18: e0293765. PMID 37883362 DOI: 10.1371/journal.pone.0293765  0.151
2018 Alexandre J, Moslehi J, Bersell KR, Funck-Brentano C, Roden DM, Salem JE. Anticancer drug-induced cardiac rhythm disorders: Current knowledge and basic underlying mechanisms. Pharmacology & Therapeutics. PMID 29698683 DOI: 10.1016/j.pharmthera.2018.04.009  0.151
2002 Roden DM. The problem, challenge and opportunity of genetic heterogeneity in monogenic diseases predisposing to sudden death. Journal of the American College of Cardiology. 40: 357-9. PMID 12106944 DOI: 10.1016/S0735-1097(02)01963-0  0.15
1997 Roden DM. A practical approach to torsade de pointes. Clinical Cardiology. 20: 285-90. PMID 9068917 DOI: 10.1002/CLC.4960200318  0.15
2012 Delaney JT, Muhammad R, Blair MA, Kor K, Fish FA, Roden DM, Darbar D. A KCNJ8 mutation associated with early repolarization and atrial fibrillation. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 14: 1428-32. PMID 22562657 DOI: 10.1093/europace/eus150  0.15
2009 Yang T, Chung SK, Zhang W, Mullins JG, McCulley CH, Crawford J, MacCormick J, Eddy CA, Shelling AN, French JK, Yang P, Skinner JR, Roden DM, Rees MI. Biophysical properties of 9 KCNQ1 mutations associated with long-QT syndrome. Circulation. Arrhythmia and Electrophysiology. 2: 417-26. PMID 19808498 DOI: 10.1161/CIRCEP.109.850149  0.15
2017 Luzum JA, Pakyz RE, Elsey AR, Haidar CE, Peterson JF, Whirl-Carrillo M, Handelman SK, Palmer K, Pulley JM, Beller M, Schildcrout JS, Field JR, Weitzel KW, Cooper-DeHoff RM, Cavallari LH, ... ... Roden DM, et al. "The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems". Clinical Pharmacology and Therapeutics. PMID 28090649 DOI: 10.1002/Cpt.630  0.15
2014 Jeff JM, Donahue BS, Brown-Gentry K, Roden DM, Crawford DC, Stein CM, Kurnik D. Genetic variation in the β1-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery. American Heart Journal. 167: 101-108.e1. PMID 24332148 DOI: 10.1016/J.Ahj.2013.09.016  0.15
2017 Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee SW, Johnson GT, Giacomini KM. New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine. Clinical Pharmacology and Therapeutics. PMID 28795399 DOI: 10.1002/Cpt.755  0.15
1987 Woosley RL, Roden DM. Pharmacologic causes of arrhythmogenic actions of antiarrhythmic drugs. The American Journal of Cardiology. 59: 19E-25E. PMID 3554949 DOI: 10.1016/0002-9149(87)90197-4  0.149
2005 Liu K, Yang T, Viswanathan PC, Roden DM. New mechanism contributing to drug-induced arrhythmia: rescue of a misprocessed LQT3 mutant. Circulation. 112: 3239-46. PMID 16301357 DOI: 10.1161/CIRCULATIONAHA.105.564008  0.149
2015 Van Wagoner DR, Piccini JP, Albert CM, Anderson ME, Benjamin EJ, Brundel B, Califf RM, Calkins H, Chen PS, Chiamvimonvat N, Darbar D, Eckhardt LL, Ellinor PT, Exner DV, Fogel RI, ... ... Roden DM, et al. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 12: e5-e29. PMID 25460864 DOI: 10.1016/J.Hrthm.2014.11.011  0.148
1989 Murray KT, Barbey JT, Kopelman HA, Siddoway LA, Echt DS, Woosley RL, Roden DM. Mexiletine and tocainide: a comparison of antiarrhythmic efficacy, adverse effects, and predictive value of lidocaine testing. Clinical Pharmacology and Therapeutics. 45: 553-61. PMID 2498025 DOI: 10.1038/Clpt.1989.72  0.148
2008 Darbar D, Kucera G, Stubblefield T, George AL, Roden DM, Kannankeril PJ, Donahue BS, Haines JL. Response to Letter Regarding Article, “Cardiac Sodium Channel ( SCN5A ) Variants Associated with Atrial Fibrillation” Circulation. 118. DOI: 10.1161/CIRCULATIONAHA.108.800888  0.148
2012 Ritchie MD, Rowan S, Kucera G, Stubblefield T, Blair M, Carter S, Roden DM, Darbar D. Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation. Journal of the American College of Cardiology. 60: 1173-81. PMID 22818067 DOI: 10.1016/J.Jacc.2012.04.030  0.148
2018 Kroncke BM, Yang T, Kannankeril P, Shoemaker MB, Roden DM. Exploiting ion channel structure to assess rare variant pathogenicity. Heart Rhythm. PMID 29330128 DOI: 10.1016/J.Hrthm.2018.01.021  0.147
2021 Salem JE, Nguyen LS, Moslehi JJ, Ederhy S, Lebrun-Vignes B, Roden DM, Funck-Brentano C, Gougis P. Anticancer drug-induced life-threatening ventricular arrhythmias: a World Health Organization pharmacovigilance study. European Heart Journal. PMID 34370839 DOI: 10.1093/eurheartj/ehab362  0.147
Hide low-probability matches.