Reuben S. Harris - Publications

Affiliations: 
Biochemistry, Molecular Bio, and Biophysics University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Virology Biology, Molecular Biology

209 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Carpenter MA, Temiz NA, Ibrahim MA, Jarvis MC, Brown MR, Argyris PP, Brown WL, Starrett GJ, Yee D, Harris RS. Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer. Plos Genetics. 19: e1011043. PMID 38033156 DOI: 10.1371/journal.pgen.1011043  0.321
2023 Harjes S, Kurup HM, Rieffer AE, Bayarjargal M, Filitcheva J, Su Y, Hale TK, Filichev VV, Harjes E, Harris RS, Jameson GB. Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nature Communications. 14: 6382. PMID 37821454 DOI: 10.1038/s41467-023-42174-w  0.316
2023 Ikeda T, Shimizu R, Nasser H, Carpenter MA, Cheng AZ, Brown WL, Sauter D, Harris RS. APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1. Mbio. e0078223. PMID 37555667 DOI: 10.1128/mbio.00782-23  0.328
2023 Wick C, Moghadasi SA, Becker JT, Fanunza E, Oh S, Bournique E, Buisson R, Harris RS. Mitochondrial double-stranded RNA triggers induction of the antiviral DNA deaminase APOBEC3A and nuclear DNA damage. The Journal of Biological Chemistry. 299: 105073. PMID 37474103 DOI: 10.1016/j.jbc.2023.105073  0.729
2023 Becker JT, Auerbach AA, Harris RS. APEX3 - an optimized tool for rapid and unbiased proximity labeling. Journal of Molecular Biology. 168145. PMID 37182813 DOI: 10.1016/j.jmb.2023.168145  0.676
2023 Ikeda T, Shimizu R, Nasser H, Carpenter MA, Cheng AZ, Brown WL, Sauter D, Harris RS. APOBEC3 degradation is the primary function of HIV-1 Vif for virus replication in the myeloid cell line THP-1. Biorxiv : the Preprint Server For Biology. PMID 37034786 DOI: 10.1101/2023.03.28.534666  0.326
2023 Harjes S, Kurup HM, Rieffer AE, Bayarjargal M, Filitcheva J, Su Y, Hale TK, Filichev VV, Harjes E, Harris RS, Jameson GB. Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Biorxiv : the Preprint Server For Biology. PMID 36824964 DOI: 10.1101/2023.02.17.528918  0.325
2023 Manjunath L, Oh S, Ortega P, Bouin A, Bournique E, Sanchez A, Martensen PM, Auerbach AA, Becker JT, Seldin M, Harris RS, Semler BL, Buisson R. APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection. Nature Communications. 14: 820. PMID 36781883 DOI: 10.1038/s41467-023-36445-9  0.69
2022 Moraes SN, Becker JT, Moghadasi SA, Shaban NM, Auerbach AA, Cheng AZ, Harris RS. Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases. Elife. 11. PMID 36458685 DOI: 10.7554/eLife.83893  0.704
2022 Auerbach AA, Becker JT, Moraes SN, Moghadasi SA, Duda JM, Salamango DJ, Harris RS. Ancestral APOBEC3B Nuclear Localization Is Maintained in Humans and Apes and Altered in Most Other Old World Primate Species. Msphere. e0045122. PMID 36374108 DOI: 10.1128/msphere.00451-22  0.745
2022 Moghadasi SA, Esler MA, Otsuka Y, Becker JT, Moraes SN, Anderson CB, Chamakuri S, Belica C, Wick C, Harki DA, Young DW, Scampavia L, Spicer TP, Shi K, Aihara H, ... ... Harris RS, et al. Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M/3CL in Living Cells. Mbio. e0078422. PMID 35471084 DOI: 10.1128/mbio.00784-22  0.667
2021 Cheng AZ, Moraes SN, Shaban NM, Fanunza E, Bierle CJ, Southern PJ, Bresnahan WA, Rice SA, Harris RS. APOBECs and Herpesviruses. Viruses. 13. PMID 33671095 DOI: 10.3390/v13030390  0.368
2020 Salamango DJ, Harris RS. Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle Arrest. Frontiers in Microbiology. 11: 622012. PMID 33510734 DOI: 10.3389/fmicb.2020.622012  0.319
2020 Conboy CB, Vélez-Reyes GL, Rathe SK, Abrahante JE, Temiz NA, Burns MB, Harris RS, Starr TK, Largaespada DA. R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers. Dna and Cell Biology. PMID 33320737 DOI: 10.1089/dna.2020.5585  0.644
2020 Moghadasi SA, Becker JT, Belica C, Wick C, Brown WL, Harris RS. Gain-of-function assay for SARS-CoV-2 M inhibition in living cells. Biorxiv : the Preprint Server For Biology. PMID 33200129 DOI: 10.1101/2020.11.09.375139  0.668
2020 Roelofs PA, Goh CY, Chua BH, Jarvis MC, Stewart TA, McCann JL, McDougle RM, Carpenter MA, Martens JW, Span PN, Kappei D, Harris RS. Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B. Elife. 9. PMID 32985974 DOI: 10.7554/eLife.61287  0.314
2020 Nakano Y, Yamamoto K, Ueda MT, Soper A, Konno Y, Kimura I, Uriu K, Kumata R, Aso H, Misawa N, Nagaoka S, Shimizu S, Mitsumune K, Kosugi Y, Juarez-Fernandez G, ... ... Harris RS, et al. A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans. Plos Pathogens. 16: e1008812. PMID 32913367 DOI: 10.1371/Journal.Ppat.1008812  0.405
2020 Law EK, Levin-Klein R, Jarvis MC, Kim H, Argyris PP, Carpenter MA, Starrett GJ, Temiz NA, Larson LK, Durfee C, Burns MB, Vogel RI, Stavrou S, Aguilera AN, Wagner S, ... ... Harris RS, et al. APOBEC3A catalyzes mutation and drives carcinogenesis in vivo. The Journal of Experimental Medicine. 217. PMID 32870257 DOI: 10.1084/Jem.20200261  0.683
2020 Salamango DJ, McCann JL, Demir Ö, Becker JT, Wang J, Lingappa JR, Temiz NA, Brown WL, Amaro RE, Harris RS. Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated using Patient HIV-1 Isolates and Computational Modeling. Journal of Virology. PMID 32847850 DOI: 10.1128/Jvi.00631-20  0.747
2020 Bhatt V, Shi K, Salamango DJ, Moeller NH, Pandey KK, Bera S, Bohl TE, Kurniawan F, Orellana K, Zhang W, Grandgenett DP, Harris RS, Sundborger-Lunna AC, Aihara H. Structural basis of host protein hijacking in human T-cell leukemia virus integration. Nature Communications. 11: 3121. PMID 32561747 DOI: 10.1038/S41467-020-16963-6  0.374
2020 Harris RS, Serebrenik AA, Argyris P, Jarvis MC, Brown WL, Bazzaro M, Vogel RI, Erickson BK, Lee SH, Goergen KM, Maurer MJ, Oberg AL, Hou X, Weroha SJ, Kaufmann SH, et al. The DNA cytosine deaminase APOBEC3B is a molecular determinant of platinum responsiveness in clear cell ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32060098 DOI: 10.1158/1078-0432.Ccr-19-2786  0.352
2020 Driscoll CB, Schuelke MR, Kottke T, Thompson JM, Wongthida P, Tonne JM, Huff AL, Miller A, Shim KG, Molan A, Wetmore C, Selby P, Samson A, Harrington K, Pandha H, ... ... Harris R, et al. APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy. Nature Communications. 11: 790. PMID 32034147 DOI: 10.1038/S41467-020-14568-7  0.328
2019 Salamango DJ, Ikeda T, Moghadasi SA, Wang J, McCann JL, Serebrenik AA, Ebrahimi D, Jarvis MC, Brown WL, Harris RS. HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators. Cell Reports. 29: 1057-1065.e4. PMID 31665623 DOI: 10.1016/J.Celrep.2019.09.057  0.424
2019 Wang J, Becker JT, Shi K, Lauer KV, Salamango DJ, Aihara H, Shaban NM, Harris RS. The Role of RNA in HIV-1 Vif-Mediated Degradation of APOBEC3H. Journal of Molecular Biology. PMID 31628948 DOI: 10.1016/J.Jmb.2019.09.014  0.748
2019 Serebrenik AA, Starrett GJ, Leenen S, Jarvis MC, Shaban NM, Salamango DJ, Nilsen H, Brown WL, Harris RS. The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase. Proceedings of the National Academy of Sciences of the United States of America. PMID 31611371 DOI: 10.1073/Pnas.1904024116  0.435
2019 Brown WL, Law EK, Argyris PP, Carpenter MA, Levin-Klein R, Ranum AN, Molan AM, Forster CL, Anderson BD, Lackey L, Harris RS. A Rabbit Monoclonal Antibody against the Antiviral and Cancer Genomic DNA Mutating Enzyme APOBEC3B. Antibodies (Basel, Switzerland). 8. PMID 31544853 DOI: 10.3390/Antib8030047  0.759
2019 Cheng AZ, Nóbrega de Moraes S, Attarian C, Yockteng-Melgar J, Jarvis MC, Biolatti M, Galitska G, Dell'Oste V, Frappier L, Bierle CJ, Rice SA, Harris RS. A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits. Journal of Virology. PMID 31534038 DOI: 10.1128/Jvi.01539-19  0.446
2019 McCann JM, Klein MM, Leland EM, Law EK, Brown WL, Salamango DJ, Harris RS. The DNA deaminase APOBEC3B interacts with the cell cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1. The Journal of Biological Chemistry. PMID 31217276 DOI: 10.1074/Jbc.Ra119.008443  0.415
2019 Ikeda T, Molan AM, Jarvis MC, Carpenter MA, Salamango DJ, Brown WL, Harris RS. HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1. The Journal of General Virology. PMID 31145054 DOI: 10.1099/Jgv.0.001276  0.483
2019 Ikeda T, Tennyson R, Walker SN, Harris RS, McNaughton B. Evolved Proteins Inhibit Entry of Enfuvirtide-Resistant HIV-1. Acs Infectious Diseases. PMID 30811933 DOI: 10.1021/Acsinfecdis.8B00362  0.391
2019 Starrett GJ, Serebrenik AA, Roelofs PA, McCann JL, Verhalen B, Jarvis MC, Stewart TA, Law EK, Krupp A, Jiang M, Martens JWM, Cahir-McFarland E, Span PN, Harris RS. Polyomavirus T Antigen Induces Expression Using an LXCXE-Dependent and TP53-Independent Mechanism. Mbio. 10. PMID 30723127 DOI: 10.1128/Mbio.02690-18  0.464
2019 Huff AL, Wongthida P, Kottke T, Thompson J, Driscoll CB, Schuelke M, Shim KG, Harris RS, Molan A, Pulido JS, Selby PJ, Harrington KJ, Melcher A, Evgin L, Vile R. Abstract A133: APOBEC3 confers resistance to oncolytic VSV therapy Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A133  0.368
2018 Carpenter MA, Law EK, Serebrenik A, Brown WL, Harris RS. A lentivirus-based system for Cas9/gRNA expression and subsequent removal by Cre-mediated recombination. Methods (San Diego, Calif.). PMID 30578845 DOI: 10.1016/J.Ymeth.2018.12.006  0.362
2018 Anderson BD, Ikeda T, Moghadasi SA, Martin AS, Brown WL, Harris RS. Natural APOBEC3C variants can elicit differential HIV-1 restriction activity. Retrovirology. 15: 78. PMID 30558640 DOI: 10.1186/S12977-018-0459-5  0.452
2018 Cheng AZ, Yockteng-Melgar J, Jarvis MC, Malik-Soni N, Borozan I, Carpenter MA, McCann JL, Ebrahimi D, Shaban NM, Marcon E, Greenblatt J, Brown WL, Frappier L, Harris RS. Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity. Nature Microbiology. PMID 30420783 DOI: 10.1038/S41564-018-0284-6  0.435
2018 Kvach MV, Barzak FM, Harjes S, Schares HAM, Jameson GB, Ayoub AM, Moorthy R, Aihara H, Harris RS, Filichev V, Harki DA, Harjes E. Inhibiting APOBEC3 activity with single-stranded DNA containing 2'-deoxyzebularine analogs. Biochemistry. PMID 30418757 DOI: 10.1021/Acs.Biochem.8B00858  0.415
2018 Ebrahimi D, Richards CM, Carpenter MA, Wang J, Ikeda T, Becker JT, Cheng AZ, McCann JL, Shaban NM, Salamango DJ, Starrett GJ, Lingappa JR, Yong J, Brown WL, Harris RS. Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease. Nature Communications. 9: 4137. PMID 30297863 DOI: 10.1038/S41467-018-06594-3  0.749
2018 Huff AL, Wongthida P, Kottke T, Thompson JM, Driscoll CB, Schuelke M, Shim KG, Harris RS, Molan A, Pulido JS, Selby PJ, Harrington KJ, Melcher A, Evgin L, Vile RG. APOBEC3 Mediates Resistance to Oncolytic Viral Therapy. Molecular Therapy Oncolytics. 11: 1-13. PMID 30294666 DOI: 10.1016/J.Omto.2018.08.003  0.367
2018 Salamango DJ, Becker JT, McCann JL, Cheng AZ, Demir Ö, Amaro RE, Brown WL, Shaban NM, Harris RS. APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction. Molecular and Cellular Biology. PMID 30224517 DOI: 10.1128/Mcb.00356-18  0.77
2018 Wagner JR, Demir O, Carpenter MA, Aihara H, Harki DA, Harris RS, Amaro RE. Determinants of Oligonucleotide Selectivity of APOBEC3B. Journal of Chemical Information and Modeling. PMID 30130104 DOI: 10.1021/Acs.Jcim.8B00427  0.353
2018 Jarvis MC, Ebrahimi D, Temiz NA, Harris RS. Mutation Signatures Including APOBEC in Cancer Cell Lines. Jnci Cancer Spectrum. 2. PMID 29888758 DOI: 10.1093/Jncics/Pky002  0.402
2018 Salamango DJ, McCann JL, Demir Ö, Brown WL, Amaro RE, Harris RS. APOBEC3B Nuclear Localization Requires two Distinct N-Terminal Domain Surfaces. Journal of Molecular Biology. PMID 29787764 DOI: 10.1016/J.Jmb.2018.04.044  0.352
2018 Peretti A, Geoghegan EM, Pastrana DV, Smola S, Feld P, Sauter M, Lohse S, Ramesh M, Lim ES, Wang D, Borgogna C, FitzGerald PC, Bliskovsky V, Starrett GJ, Law EK, ... Harris RS, et al. Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution. Cell Host & Microbe. 23: 628-635.e7. PMID 29746834 DOI: 10.1016/J.Chom.2018.04.005  0.362
2018 St Martin A, Salamango D, Serebrenik A, Shaban N, Brown WL, Donati F, Munagala U, Conticello SG, Harris RS. A fluorescent reporter for quantification and enrichment of DNA editing by APOBEC-Cas9 or cleavage by Cas9 in living cells. Nucleic Acids Research. PMID 29746667 DOI: 10.1093/Nar/Gky332  0.398
2018 Ikeda T, Symeonides M, Albin JS, Li M, Thali M, Harris RS. HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G. Plos Pathogens. 14: e1007010. PMID 29677220 DOI: 10.1371/Journal.Ppat.1007010  0.799
2018 Wang J, Shaban NM, Land AM, Brown WL, Harris RS. SIVVif and Human APOBEC3B Interactions Resemble Those Between HIV-1 Vif and Human APOBEC3G. Journal of Virology. PMID 29618650 DOI: 10.1128/Jvi.00447-18  0.455
2018 Hayward JA, Tachedjian M, Cui J, Cheng AZ, Johnson A, Baker M, Harris RS, Wang LF, Tachedjian G. Differential evolution of antiretroviral restriction factors in pteropid bats as revealed by APOBEC3 gene complexity. Molecular Biology and Evolution. PMID 29617834 DOI: 10.1093/Molbev/Msy048  0.433
2018 Venkatesan S, Rosenthal R, Kanu N, McGranahan N, Bartek J, Quezada SA, Hare J, Harris RS, Swanton C. APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution. Annals of Oncology : Official Journal of the European Society For Medical Oncology. PMID 29324969 DOI: 10.1093/Annonc/Mdy003  0.402
2018 Meissner T, Amallraja A, Willis S, Harris R, Leyland-Jones B, Williams C. Abstract PD8-10: APOBEC mutation signature in breast cancer correlates with tumor mutation burden and poor responses to therapy Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-Pd8-10  0.381
2017 Shaban NM, Shi K, Lauer KV, Carpenter MA, Richards CM, Salamango D, Wang J, Lopresti MW, Banerjee S, Levin-Klein R, Brown WL, Aihara H, Harris RS. The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism. Molecular Cell. PMID 29290613 DOI: 10.1016/J.Molcel.2017.12.010  0.417
2017 Shi K, Demir Ö, Carpenter MA, Wagner J, Kurahashi K, Harris RS, Amaro RE, Aihara H. Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B. Scientific Reports. 7: 17415. PMID 29234087 DOI: 10.1038/S41598-017-17694-3  0.349
2017 Gorle S, Pan Y, Sun Z, Shlyakhtenko LS, Harris RS, Lyubchenko YL, Vuković L. Computational Model and Dynamics of Monomeric Full-Length APOBEC3G. Acs Central Science. 3: 1180-1188. PMID 29202020 DOI: 10.1021/Acscentsci.7B00346  0.346
2017 Olson ME, Harris RS, Harki DA. APOBEC Enzymes as Targets for Virus and Cancer Therapy. Cell Chemical Biology. PMID 29153851 DOI: 10.1016/J.Chembiol.2017.10.007  0.457
2017 Nakano Y, Misawa N, Juarez-Fernandez G, Moriwaki M, Nakaoka S, Funo T, Yamada E, Soper A, Yoshikawa R, Ebrahimi D, Tachiki Y, Iwami S, Harris RS, Koyanagi Y, Sato K. Correction: HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation. Plos Pathogens. 13: e1006606. PMID 28880964 DOI: 10.1371/Journal.Ppat.1006606  0.346
2017 Molan AM, Hanson HM, Chweya CM, Anderson BD, Starrett GJ, Richards CM, Harris RS. APOBEC3B lysine residues are dispensable for DNA cytosine deamination, HIV-1 restriction, and nuclear localization. Virology. 511: 74-81. PMID 28841445 DOI: 10.1016/J.Virol.2017.08.025  0.505
2017 Tennyson RL, Walker SN, Ikeda T, Harris RS, McNaughton BR. Evaluation of sequence variability in HIV-1 gp41 C-peptide helix-grafted proteins. Bioorganic & Medicinal Chemistry. PMID 28811070 DOI: 10.1016/J.Bmc.2017.07.064  0.323
2017 Nikkilä J, Kumar R, Campbell J, Brandsma I, Pemberton HN, Wallberg F, Nagy K, Scheer I, Vertessy BG, Serebrenik AA, Monni V, Harris RS, Pettitt SJ, Ashworth A, Lord CJ. Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells. British Journal of Cancer. PMID 28535155 DOI: 10.1038/Bjc.2017.133  0.306
2017 Nakano Y, Misawa N, Juarez-Fernandez G, Moriwaki M, Nakaoka S, Funo T, Yamada E, Soper A, Yoshikawa R, Ebrahimi D, Tachiki Y, Iwami S, Harris RS, Koyanagi Y, Sato K. HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation. Plos Pathogens. 13: e1006348. PMID 28475648 DOI: 10.1371/Journal.Ppat.1006348  0.455
2017 Ikeda T, Shimoda M, Ebrahimi D, VandeBerg JL, Harris RS, Koito A, Maeda K. Opossum APOBEC1 is a DNA mutator with retrovirus and retroelement restriction activity. Scientific Reports. 7: 46719. PMID 28429755 DOI: 10.1038/Srep46719  0.429
2017 Starrett GJ, Marcelus C, Cantalupo PG, Katz JP, Cheng J, Akagi K, Thakuria M, Rabinowits G, Wang LC, Symer DE, Pipas JM, Harris RS, DeCaprio JA. Merkel Cell Polyomavirus Exhibits Dominant Control of the Tumor Genome and Transcriptome in Virus-Associated Merkel Cell Carcinoma. Mbio. 8. PMID 28049147 DOI: 10.1128/Mbio.02079-16  0.335
2017 Harris R, Starrett G, McCann J, Carpenter M. Abstract P5-06-03: A solution to the APOBEC mutation paradox in breast cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P5-06-03  0.37
2017 Demir O, Wagner JR, Shi K, Carpenter MA, Banerjee S, Shaban NM, Kurahashi K, Salamango DJ, McCann JL, Starrett GJ, Duffy JV, Harki D, Aihara H, Amaro RE, Harris RS. Abstract 5236: The dynamic interplay between the cancer genome mutating enzyme APOBEC3B and DNA substrates Cancer Research. 77: 5236-5236. DOI: 10.1158/1538-7445.Am2017-5236  0.383
2016 Pan Y, Sun Z, Maiti A, Kanai T, Matsuo H, Li M, Harris RS, Shlyakhtenko LS, Lyubchenko YL. Nanoscale Characterization of Interaction of APOBEC3G with RNA. Biochemistry. PMID 28029777 DOI: 10.1021/Acs.Biochem.6B01189  0.304
2016 Shi K, Carpenter MA, Banerjee S, Shaban NM, Kurahashi K, Salamango DJ, McCann JL, Starrett GJ, Duffy JV, Demir Ö, Amaro RE, Harki DA, Harris RS, Aihara H. Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B. Nature Structural & Molecular Biology. PMID 27991903 DOI: 10.1038/Nsmb.3344  0.411
2016 Harris RS, Anderson BD. Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes. Plos Pathogens. 12: e1005958. PMID 27907174 DOI: 10.1371/Journal.Ppat.1005958  0.481
2016 Richards CM, Li M, Perkins AL, Rathore A, Harki DA, Harris RS. Reassessing APOBEC3G inhibition by HIV-1 Vif-derived peptides. Journal of Molecular Biology. PMID 27887868 DOI: 10.1016/J.Jmb.2016.11.012  0.415
2016 Law EK, Sieuwerts AM, LaPara K, Leonard B, Starrett GJ, Molan AM, Temiz NA, Vogel RI, Meijer-van Gelder ME, Sweep FC, Span PN, Foekens JA, Martens JW, Yee D, Harris RS. The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer. Science Advances. 2: e1601737. PMID 27730215 DOI: 10.1126/Sciadv.1601737  0.353
2016 Starrett GJ, Luengas EM, McCann JL, Ebrahimi D, Temiz NA, Love RP, Feng Y, Adolph MB, Chelico L, Law EK, Carpenter MA, Harris RS. The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis. Nature Communications. 7: 12918. PMID 27650891 DOI: 10.1038/Ncomms12918  0.435
2016 Kanu N, Cerone MA, Goh G, Zalmas LP, Bartkova J, Dietzen M, McGranahan N, Rogers R, Law EK, Gromova I, Kschischo M, Walton MI, Rossanese OW, Bartek J, Harris RS, et al. DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer. Genome Biology. 17: 185. PMID 27634334 DOI: 10.1186/S13059-016-1042-9  0.387
2016 Shlyakhtenko LS, Dutta S, Li M, Harris RS, Lyubchenko YL. Single-Molecule Force Spectroscopy Studies of APOBEC3A-ssDNA Complexes. Biochemistry. PMID 27182892 DOI: 10.1021/Acs.Biochem.6B00214  0.328
2016 Akre MK, Starrett GJ, Quist JS, Temiz NA, Carpenter MA, Tutt AN, Grigoriadis A, Harris RS. Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B. Plos One. 11: e0155391. PMID 27163364 DOI: 10.1371/Journal.Pone.0155391  0.418
2016 Verhalen B, Starrett GJ, Harris RS, Jiang M. Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses. Journal of Virology. PMID 27147740 DOI: 10.1128/Jvi.00771-16  0.435
2016 Shaban NM, Shi K, Li M, Aihara H, Harris RS. 1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure. Journal of Molecular Biology. PMID 27139641 DOI: 10.1016/J.Jmb.2016.04.026  0.303
2016 Leonard B, Starrett GJ, Maurer MJ, Oberg A, Van Bockstal M, Van Dorpe J, De Wever O, Helleman J, Sieuwerts AM, Berns EM, Martens JW, Anderson B, Brown WL, Kalli KR, Kaufmann SH, ... Harris RS, et al. APOBEC3G expression correlates with T cell infiltration and improved clinical outcomes in high-grade serous ovarian carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27016308 DOI: 10.1158/1078-0432.Ccr-15-2910  0.35
2016 Leonard B, McCann J, Starrett G, Kosyakovsky L, Amy M, Burns M, McDougle R, Parker P, Brown W, Harris R. Abstract B43: APOBEC3B upregulation by the PKC-NFκB pathway in breast cancer Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-B43  0.666
2016 Harris R, Law E, Sieuwerts A, LaPara K, Leonard B, Starrett G, Temiz N, Sweep F, Span P, Foekens J, Martens J, Yee D. Abstract S4-07: Tamoxifen resistance driven by the DNA cytosine deaminase APOBEC3B in recurrent estrogen receptor positive breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-S4-07  0.338
2016 McCann J, Leonard B, Starrett G, Kosyakovsky L, Molan A, Burns M, McDougle R, Parker P, Brown W, Harris R. Abstract P4-08-02: APOBEC3B upregulation by the PKC-NFκB pathway in breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P4-08-02  0.664
2016 LaPara KS, Law E, Harris R, Yee D. Abstract 295: The cytosine deaminase APOBEC3B affects responses to therapy in estrogen receptor positive breast cancer cells Cancer Research. 76: 295-295. DOI: 10.1158/1538-7445.Am2016-295  0.344
2016 Rajani K, Shim KG, Kazemi NY, Gendron W, Kottke T, Molan A, Driscoll C, Harris R, Vile R. 64. Generation of Tumor Cells Resistant to Oncolysis Is Mediated Through Virus Induced APOBEC Expression Molecular Therapy. 24: S28. DOI: 10.1016/S1525-0016(16)32873-8  0.33
2015 Richards C, Albin JS, Demir Ö, Shaban NM, Luengas EM, Land AM, Anderson BD, Holten JR, Anderson JS, Harki DA, Amaro RE, Harris RS. The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches. Cell Reports. PMID 26628363 DOI: 10.1016/J.Celrep.2015.10.067  0.794
2015 Anderson BD, Harris RS. Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-β/RUNX axis. Science Advances. 1: e1500296. PMID 26601257 DOI: 10.1126/Sciadv.1500296  0.404
2015 Land AM, Wang J, Law EK, Aberle R, Kirmaier A, Krupp A, Johnson WE, Harris RS. Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV Vif. Oncotarget. PMID 26544511 DOI: 10.18632/Oncotarget.5483  0.507
2015 Shlyakhtenko LS, Dutta S, Banga J, Li M, Harris RS, Lyubchenko YL. APOBEC3G Interacts with ssDNA by Two Modes: AFM Studies. Scientific Reports. 5: 15648. PMID 26503602 DOI: 10.1038/Srep15648  0.301
2015 Yoshikawa R, Izumi T, Yamada E, Nakano Y, Misawa N, Ren F, Carpenter MA, Ikeda T, Münk C, Harris RS, Miyazawa T, Koyanagi Y, Sato K. A naturally occurring domestic cat APOBEC3 variant confers resistance to FIV infection. Journal of Virology. PMID 26491161 DOI: 10.1128/Jvi.02612-15  0.36
2015 Leonard B, McCann JL, Starrett GJ, Kosyakovsky L, Luengas EM, Molan AM, Burns MB, McDougle RM, Parker PJ, Brown WL, Harris RS. The PKC/NF-κB Signaling Pathway Induces APOBEC3B Expression in Multiple Human Cancers. Cancer Research. 75: 4538-47. PMID 26420215 DOI: 10.1158/0008-5472.Can-15-2171-T  0.668
2015 Shi K, Carpenter MA, Kurahashi K, Harris RS, Aihara H. Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain. The Journal of Biological Chemistry. PMID 26416889 DOI: 10.1074/Jbc.M115.679951  0.41
2015 Swanton C, McGranahan N, Starrett GJ, Harris RS. APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity. Cancer Discovery. 5: 704-12. PMID 26091828 DOI: 10.1158/2159-8290.Cd-15-0344  0.347
2015 Kouno T, Luengas EM, Shigematsu M, Shandilya SM, Zhang J, Chen L, Hara M, Schiffer CA, Harris RS, Matsuo H. Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G. Nature Structural & Molecular Biology. 22: 485-91. PMID 25984970 DOI: 10.1038/Nsmb.3033  0.313
2015 Kane JR, Stanley DJ, Hultquist JF, Johnson JR, Mietrach N, Binning JM, Jónsson SR, Barelier S, Newton BW, Johnson TL, Franks-Skiba KE, Li M, Brown WL, Gunnarsson HI, Adalbjornsdóttir A, ... ... Harris RS, et al. Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity. Cell Reports. 11: 1236-50. PMID 25981045 DOI: 10.1016/J.Celrep.2015.04.038  0.673
2015 Harris RS, Perrino FW, Shaban NM. The multidimensional nature of antiviral innate immunity. Cell Host & Microbe. 17: 423-5. PMID 25856751 DOI: 10.1016/J.Chom.2015.03.011  0.352
2015 Harris RS. Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer. Breast Cancer Research : Bcr. 17: 8. PMID 25848704 DOI: 10.1186/S13058-014-0498-3  0.437
2015 Harris RS, Dudley JP. APOBECs and virus restriction. Virology. 479: 131-45. PMID 25818029 DOI: 10.1016/J.Virol.2015.03.012  0.409
2015 Burns MB, Leonard B, Harris RS. APOBEC3B: pathological consequences of an innate immune DNA mutator. Biomedical Journal. 38: 102-10. PMID 25566802 DOI: 10.4103/2319-4170.148904  0.719
2015 Yoshikawa R, Takeuchi JS, Yamada E, Nakano Y, Ren F, Tanaka H, Münk C, Harris RS, Miyazawa T, Koyanagi Y, Sato K. Vif determines the requirement for CBF-β in APOBEC3 degradation. The Journal of General Virology. 96: 887-92. PMID 25516542 DOI: 10.1099/Jgv.0.000027  0.354
2014 Vieira VC, Leonard B, White EA, Starrett GJ, Temiz NA, Lorenz LD, Lee D, Soares MA, Lambert PF, Howley PM, Harris RS. Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B. Mbio. 5. PMID 25538195 DOI: 10.1128/Mbio.02234-14  0.326
2014 Refsland EW, Hultquist JF, Luengas EM, Ikeda T, Shaban NM, Law EK, Brown WL, Reilly C, Emerman M, Harris RS. Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity. Plos Genetics. 10: e1004761. PMID 25411794 DOI: 10.1371/Journal.Pgen.1004761  0.833
2014 Land AM, Shaban NM, Evans L, Hultquist JF, Albin JS, Harris RS. APOBEC3F determinants of HIV-1 Vif sensitivity. Journal of Virology. 88: 12923-7. PMID 25142588 DOI: 10.1128/Jvi.02362-14  0.804
2014 Zhang W, Wang H, Li Z, Liu X, Liu G, Harris RS, Yu XF. Cellular requirements for bovine immunodeficiency virus Vif-mediated inactivation of bovine APOBEC3 proteins. Journal of Virology. 88: 12528-40. PMID 25142583 DOI: 10.1128/Jvi.02072-14  0.409
2014 Sieuwerts AM, Willis S, Burns MB, Look MP, Meijer-Van Gelder ME, Schlicker A, Heideman MR, Jacobs H, Wessels L, Leyland-Jones B, Gray KP, Foekens JA, Harris RS, Martens JW. Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers. Hormones & Cancer. 5: 405-13. PMID 25123150 DOI: 10.1007/S12672-014-0196-8  0.636
2014 Matsui M, Shindo K, Izumi T, Io K, Shinohara M, Komano J, Kobayashi M, Kadowaki N, Harris RS, Takaori-Kondo A. Small molecules that inhibit Vif-induced degradation of APOBEC3G. Virology Journal. 11: 122. PMID 24986077 DOI: 10.1186/1743-422X-11-122  0.413
2014 Shlyakhtenko LS, Lushnikov AJ, Li M, Harris RS, Lyubchenko YL. Interaction of APOBEC3A with DNA assessed by atomic force microscopy. Plos One. 9: e99354. PMID 24905100 DOI: 10.1371/Journal.Pone.0099354  0.424
2014 Albin JS, Brown WL, Harris RS. Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus. Virology. 450: 49-54. PMID 24503066 DOI: 10.1016/J.Virol.2013.11.041  0.805
2014 Matsui Y, Shindo K, Nagata K, Io K, Tada K, Iwai F, Kobayashi M, Kadowaki N, Harris RS, Takaori-Kondo A. Defining HIV-1 Vif residues that interact with CBFβ by site-directed mutagenesis. Virology. 449: 82-7. PMID 24418540 DOI: 10.1016/J.Virol.2013.11.004  0.448
2014 Li J, Chen Y, Li M, Carpenter MA, McDougle RM, Luengas EM, Macdonald PJ, Harris RS, Mueller JD. APOBEC3 multimerization correlates with HIV-1 packaging and restriction activity in living cells. Journal of Molecular Biology. 426: 1296-307. PMID 24361275 DOI: 10.1016/J.Jmb.2013.12.014  0.463
2013 Shee C, Cox BD, Gu F, Luengas EM, Joshi MC, Chiu LY, Magnan D, Halliday JA, Frisch RL, Gibson JL, Nehring RB, Do HG, Hernandez M, Li L, Herman C, ... ... Harris RS, et al. Engineered proteins detect spontaneous DNA breakage in human and bacterial cells. Elife. 2: e01222. PMID 24171103 DOI: 10.7554/Elife.01222  0.659
2013 Leonard B, Hart SN, Burns MB, Carpenter MA, Temiz NA, Rathore A, Vogel RI, Nikas JB, Law EK, Brown WL, Li Y, Zhang Y, Maurer MJ, Oberg AL, Cunningham JM, ... ... Harris RS, et al. APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma. Cancer Research. 73: 7222-31. PMID 24154874 DOI: 10.1158/0008-5472.Can-13-1753  0.68
2013 Harris RS. Cancer mutation signatures, DNA damage mechanisms, and potential clinical implications. Genome Medicine. 5: 87. PMID 24073723 DOI: 10.1186/Gm490  0.416
2013 Shlyakhtenko LS, Lushnikov AY, Miyagi A, Li M, Harris RS, Lyubchenko YL. Atomic force microscopy studies of APOBEC3G oligomerization and dynamics. Journal of Structural Biology. 184: 217-25. PMID 24055458 DOI: 10.1016/J.Jsb.2013.09.008  0.372
2013 Rathore A, Carpenter MA, Demir Ö, Ikeda T, Li M, Shaban NM, Law EK, Anokhin D, Brown WL, Amaro RE, Harris RS. The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution. Journal of Molecular Biology. 425: 4442-54. PMID 23938202 DOI: 10.1016/J.Jmb.2013.07.040  0.391
2013 Ali S, Karki N, Bhattacharya C, Zhu R, MacDuff DA, Stenglein MD, Schumacher AJ, Demorest ZL, Harris RS, Matin A, Aggarwal S. APOBEC3 inhibits DEAD-END function to regulate microRNA activity. Bmc Molecular Biology. 14: 16. PMID 23890083 DOI: 10.1186/1471-2199-14-16  0.769
2013 Burns MB, Temiz NA, Harris RS. Evidence for APOBEC3B mutagenesis in multiple human cancers. Nature Genetics. 45: 977-83. PMID 23852168 DOI: 10.1038/Ng.2701  0.69
2013 Refsland EW, Harris RS. The APOBEC3 family of retroelement restriction factors. Current Topics in Microbiology and Immunology. 371: 1-27. PMID 23686230 DOI: 10.1007/978-3-642-37765-5_1  0.8
2013 Bohn MF, Shandilya SM, Albin JS, Kouno T, Anderson BD, McDougle RM, Carpenter MA, Rathore A, Evans L, Davis AN, Zhang J, Lu Y, Somasundaran M, Matsuo H, Harris RS, et al. Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain. Structure (London, England : 1993). 21: 1042-50. PMID 23685212 DOI: 10.1016/J.Str.2013.04.010  0.791
2013 Land AM, Law EK, Carpenter MA, Lackey L, Brown WL, Harris RS. Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic. The Journal of Biological Chemistry. 288: 17253-60. PMID 23640892 DOI: 10.1074/Jbc.M113.458661  0.755
2013 Harjes S, Solomon WC, Li M, Chen KM, Harjes E, Harris RS, Matsuo H. Impact of H216 on the DNA binding and catalytic activities of the HIV restriction factor APOBEC3G. Journal of Virology. 87: 7008-14. PMID 23596292 DOI: 10.1128/Jvi.03173-12  0.421
2013 McDougle RM, Hultquist JF, Stabell AC, Sawyer SL, Harris RS. D316 is critical for the enzymatic activity and HIV-1 restriction potential of human and rhesus APOBEC3B. Virology. 441: 31-9. PMID 23542011 DOI: 10.1016/J.Virol.2013.03.003  0.706
2013 Burns MB, Lackey L, Carpenter MA, Rathore A, Land AM, Leonard B, Refsland EW, Kotandeniya D, Tretyakova N, Nikas JB, Yee D, Temiz NA, Donohue DE, McDougle RM, Brown WL, ... ... Harris RS, et al. APOBEC3B is an enzymatic source of mutation in breast cancer. Nature. 494: 366-70. PMID 23389445 DOI: 10.1038/Nature11881  0.798
2013 Lackey L, Law EK, Brown WL, Harris RS. Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination. Cell Cycle (Georgetown, Tex.). 12: 762-72. PMID 23388464 DOI: 10.4161/Cc.23713  0.78
2013 Albin JS, Anderson JS, Johnson JR, Harjes E, Matsuo H, Krogan NJ, Harris RS. Dispersed sites of HIV Vif-dependent polyubiquitination in the DNA deaminase APOBEC3F. Journal of Molecular Biology. 425: 1172-82. PMID 23318957 DOI: 10.1016/J.Jmb.2013.01.010  0.77
2013 Olson ME, Li M, Harris RS, Harki DA. Small-molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4-amino-1,2,4-triazole-3-thiol scaffold. Chemmedchem. 8: 112-7. PMID 23180603 DOI: 10.1002/Cmdc.201200411  0.407
2013 Harris RS. Abstract IA23: Molecular and clinical impact of APOBEC3B mutagenesis in breast cancer Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-Ia23  0.362
2013 Harris R. Abstract A133: The DNA cytosine deaminase APOBEC3B drives mutagenesis in breast cancer Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-A133  0.386
2013 Conboy CB, Tschida BR, Hu H, Burns MB, Temiz NA, Kuka T, Keng VW, Toffanin S, Harris RS, Llovet J, Starr TK, Largaespada DA. Abstract A242: R-spondin 2 drives Wnt signaling and tumor formation in breast and liver cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A242  0.657
2013 Sieuwerts A, Burns M, Look M, Gelder MM, Schlicker A, Heidemann, Jacobs H, Wessels L, Willis S, Leyland-Jones B, Gray K, Foekens J, Harris R, Martens J. Abstract S6-05: High levels of APOBEC3B, a DNA deaminase and an enzymatic source of C-to-T transitions, are a validated marker of poor outcome in estrogen receptor-positive breast cancer Cancer Research. 73. DOI: 10.1158/0008-5472.Sabcs13-S6-05  0.669
2013 Harris R. Abstract P5-07-10: APOBEC3B drives mutagenesis in breast cancer Cancer Research. 73. DOI: 10.1158/0008-5472.Sabcs13-P5-07-10  0.382
2013 Carpenter MA, Li M, Rathore A, Lackey L, Law EK, Land AM, Leonard B, Shandilya SM, Bohn M, Schiffer CA, Brown WL, Harris RS. 116 Deamination of both methyl- and normal-cytosine by the foreign DNA restriction enzyme APOBEC3A Journal of Biomolecular Structure and Dynamics. 31: 74-74. DOI: 10.1080/07391102.2013.786358  0.775
2013 Burns MB, Lackey L, Carpenter MA, Rathore A, Land AM, Leonard B, Refsland EW, Kotandeniya D, Tretyakova N, Nikas JB, Yee D, Temiz NA, Donohue DE, McDougle RM, Brown WL, ... ... Harris RS, et al. Correction: Corrigendum: APOBEC3B is an enzymatic source of mutation in breast cancer Nature. 502: 580-580. DOI: 10.1038/Nature12667  0.783
2012 Shindo K, Li M, Gross PJ, Brown WL, Harjes E, Lu Y, Matsuo H, Harris RS. A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G. Biology. 1: 260-76. PMID 24832226 DOI: 10.3390/Biology1020260  0.41
2012 Stanley DJ, Bartholomeeusen K, Crosby DC, Kim DY, Kwon E, Yen L, Cartozo NC, Li M, Jäger S, Mason-Herr J, Hayashi F, Yokoyama S, Krogan NJ, Harris RS, Peterlin BM, et al. Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G. Plos Pathogens. 8: e1003085. PMID 23300442 DOI: 10.1371/Journal.Ppat.1003085  0.448
2012 Harris RS, Hultquist JF, Evans DT. The restriction factors of human immunodeficiency virus. The Journal of Biological Chemistry. 287: 40875-83. PMID 23043100 DOI: 10.1074/Jbc.R112.416925  0.677
2012 Solyom S, Ewing AD, Rahrmann EP, Doucet T, Nelson HH, Burns MB, Harris RS, Sigmon DF, Casella A, Erlanger B, Wheelan S, Upton KR, Shukla R, Faulkner GJ, Largaespada DA, et al. Extensive somatic L1 retrotransposition in colorectal tumors. Genome Research. 22: 2328-38. PMID 22968929 DOI: 10.1101/Gr.145235.112  0.646
2012 Carpenter MA, Li M, Rathore A, Lackey L, Law EK, Land AM, Leonard B, Shandilya SM, Bohn MF, Schiffer CA, Brown WL, Harris RS. Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A. The Journal of Biological Chemistry. 287: 34801-8. PMID 22896697 DOI: 10.1074/Jbc.M112.385161  0.78
2012 Shlyakhtenko LS, Lushnikov AY, Miyagi A, Li M, Harris RS, Lyubchenko YL. Nanoscale structure and dynamics of ABOBEC3G complexes with single-stranded DNA. Biochemistry. 51: 6432-40. PMID 22809226 DOI: 10.1021/Bi300733D  0.372
2012 Refsland EW, Hultquist JF, Harris RS. Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n. Plos Pathogens. 8: e1002800. PMID 22807680 DOI: 10.1371/Journal.Ppat.1002800  0.831
2012 Hultquist JF, McDougle RM, Anderson BD, Harris RS. HIV type 1 viral infectivity factor and the RUNX transcription factors interact with core binding factor β on genetically distinct surfaces. Aids Research and Human Retroviruses. 28: 1543-51. PMID 22725134 DOI: 10.1089/Aid.2012.0142  0.66
2012 Nowarski R, Wilner OI, Cheshin O, Shahar OD, Kenig E, Baraz L, Britan-Rosich E, Nagler A, Harris RS, Goldberg M, Willner I, Kotler M. APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair. Blood. 120: 366-75. PMID 22645179 DOI: 10.1182/Blood-2012-01-402123  0.405
2012 Lackey L, Demorest ZL, Land AM, Hultquist JF, Brown WL, Harris RS. APOBEC3B and AID have similar nuclear import mechanisms. Journal of Molecular Biology. 419: 301-14. PMID 22446380 DOI: 10.1016/J.Jmb.2012.03.011  0.804
2012 Hultquist JF, Binka M, LaRue RS, Simon V, Harris RS. Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors. Journal of Virology. 86: 2874-7. PMID 22205746 DOI: 10.1128/Jvi.06950-11  0.798
2012 Jäger S, Kim DY, Hultquist JF, Shindo K, LaRue RS, Kwon E, Li M, Anderson BD, Yen L, Stanley D, Mahon C, Kane J, Franks-Skiba K, Cimermancic P, Burlingame A, ... ... Harris RS, et al. Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature. 481: 371-5. PMID 22190037 DOI: 10.1038/Nature10693  0.817
2012 Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, ... ... Harris RS, et al. First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G. Acs Chemical Biology. 7: 506-17. PMID 22181350 DOI: 10.1021/Cb200440Y  0.424
2012 Macdonald PJ, Chen Y, Li M, Harris RS, Mueller JD. Fluorescence Fluctuation Spectroscopy Applied to Cell-Free Expression, Chromophore Maturation and Protein-DNA Interaction Biophysical Journal. 102: 208a. DOI: 10.1016/J.Bpj.2011.11.1134  0.4
2012 Olson ME, Li M, Harris RS, Harki DA. Back Cover: Small-Molecule APOBEC3G DNA Cytosine Deaminase Inhibitors Based on a 4-Amino-1,2,4-triazole-3-thiol Scaffold (ChemMedChem 1/2013) Chemmedchem. 8: 172-172. DOI: 10.1002/Cmdc.201290068  0.315
2011 Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS. Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1. Journal of Virology. 85: 11220-34. PMID 21835787 DOI: 10.1128/Jvi.05238-11  0.811
2011 Demorest ZL, Li M, Harris RS. Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein. The Journal of Biological Chemistry. 286: 26568-75. PMID 21659520 DOI: 10.1074/Jbc.M111.235721  0.788
2011 Shlyakhtenko LS, Lushnikov AY, Li M, Lackey L, Harris RS, Lyubchenko YL. Atomic force microscopy studies provide direct evidence for dimerization of the HIV restriction factor APOBEC3G. The Journal of Biological Chemistry. 286: 3387-95. PMID 21123176 DOI: 10.1074/Jbc.M110.195685  0.757
2011 Burns MB, Lackey L, Land A, Rathore A, Refsland E, Harris R. Abstract LB-193: APOBEC3 catalyzed genomic mutations in breast cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-193  0.795
2010 Albin JS, LaRue RS, Weaver JA, Brown WL, Shindo K, Harjes E, Matsuo H, Harris RS. A single amino acid in human APOBEC3F alters susceptibility to HIV-1 Vif. The Journal of Biological Chemistry. 285: 40785-92. PMID 20971849 DOI: 10.1074/Jbc.M110.173161  0.811
2010 Offer SM, Pan-Hammarström Q, Hammarström L, Harris RS. Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID. Plos One. 5: e12260. PMID 20805886 DOI: 10.1371/Journal.Pone.0012260  0.689
2010 Albin JS, Haché G, Hultquist JF, Brown WL, Harris RS. Long-term restriction by APOBEC3F selects human immunodeficiency virus type 1 variants with restored Vif function. Journal of Virology. 84: 10209-19. PMID 20686027 DOI: 10.1128/Jvi.00632-10  0.793
2010 Demorest ZL, MacDuff DA, Brown WL, Morham SG, Parise LV, Harris RS. The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination. Plos One. 5: e11660. PMID 20652029 DOI: 10.1371/Journal.Pone.0011660  0.794
2010 Hastings PJ, Hersh MN, Thornton PC, Fonville NC, Slack A, Frisch RL, Ray MP, Harris RS, Leal SM, Rosenberg SM. Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells. Plos One. 5: e10862. PMID 20523737 DOI: 10.1371/Journal.Pone.0010862  0.633
2010 Larue RS, Lengyel J, Jónsson SR, Andrésdóttir V, Harris RS. Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity. Journal of Virology. 84: 8193-201. PMID 20519393 DOI: 10.1128/Jvi.00685-10  0.706
2010 Sadler HA, Stenglein MD, Harris RS, Mansky LM. APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis. Journal of Virology. 84: 7396-404. PMID 20463080 DOI: 10.1128/Jvi.00056-10  0.701
2010 Refsland EW, Stenglein MD, Shindo K, Albin JS, Brown WL, Harris RS. Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction. Nucleic Acids Research. 38: 4274-84. PMID 20308164 DOI: 10.1093/Nar/Gkq174  0.806
2010 Shandilya SM, Nalam MN, Nalivaika EA, Gross PJ, Valesano JC, Shindo K, Li M, Munson M, Royer WE, Harjes E, Kono T, Matsuo H, Harris RS, Somasundaran M, Schiffer CA. Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces. Structure (London, England : 1993). 18: 28-38. PMID 20152150 DOI: 10.1016/J.Str.2009.10.016  0.363
2010 Albin JS, Harris RS. Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics. Expert Reviews in Molecular Medicine. 12: e4. PMID 20096141 DOI: 10.1017/S1462399409001343  0.8
2010 Stenglein MD, Burns MB, Li M, Lengyel J, Harris RS. APOBEC3 proteins mediate the clearance of foreign DNA from human cells. Nature Structural & Molecular Biology. 17: 222-9. PMID 20062055 DOI: 10.1038/Nsmb.1744  0.786
2009 Hultquist JF, Harris RS. Leveraging APOBEC3 proteins to alter the HIV mutation rate and combat AIDS. Future Virology. 4: 605. PMID 20174454 DOI: 10.2217/Fvl.09.59  0.694
2009 Haché G, Harris RS. CEM-T4 cells do not lack an APOBEC3G cofactor. Plos Pathogens. 5: e1000528. PMID 19649317 DOI: 10.1371/Journal.Ppat.1000528  0.415
2009 Harjes E, Gross PJ, Chen KM, Lu Y, Shindo K, Nowarski R, Gross JD, Kotler M, Harris RS, Matsuo H. An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model. Journal of Molecular Biology. 389: 819-32. PMID 19389408 DOI: 10.1016/J.Jmb.2009.04.031  0.32
2009 Haché G, Abbink TE, Berkhout B, Harris RS. Optimal translation initiation enables Vif-deficient human immunodeficiency virus type 1 to escape restriction by APOBEC3G. Journal of Virology. 83: 5956-60. PMID 19297501 DOI: 10.1128/Jvi.00045-09  0.432
2009 MacDuff DA, Demorest ZL, Harris RS. AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity. Nucleic Acids Research. 37: 1854-67. PMID 19188259 DOI: 10.1093/Nar/Gkp030  0.808
2009 LaRue RS, Andrésdóttir V, Blanchard Y, Conticello SG, Derse D, Emerman M, Greene WC, Jónsson SR, Landau NR, Löchelt M, Malik HS, Malim MH, Münk C, O'Brien SJ, Pathak VK, ... ... Harris RS, et al. Guidelines for naming nonprimate APOBEC3 genes and proteins. Journal of Virology. 83: 494-7. PMID 18987154 DOI: 10.1128/Jvi.01976-08  0.655
2008 LaRue RS, Jónsson SR, Silverstein KA, Lajoie M, Bertrand D, El-Mabrouk N, Hötzel I, Andrésdóttir V, Smith TP, Harris RS. The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals. Bmc Molecular Biology. 9: 104. PMID 19017397 DOI: 10.1186/1471-2199-9-104  0.682
2008 Harris RS. Enhancing immunity to HIV through APOBEC. Nature Biotechnology. 26: 1089-90. PMID 18846074 DOI: 10.1038/Nbt1008-1089  0.409
2008 Stenglein MD, Matsuo H, Harris RS. Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization. Journal of Virology. 82: 9591-9. PMID 18667511 DOI: 10.1128/Jvi.02471-07  0.627
2008 DeHart JL, Bosque A, Harris RS, Planelles V. Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation. Journal of Virology. 82: 9265-72. PMID 18596088 DOI: 10.1128/Jvi.00377-08  0.402
2008 Haché G, Shindo K, Albin JS, Harris RS. Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G. Current Biology : Cb. 18: 819-24. PMID 18501607 DOI: 10.1016/J.Cub.2008.04.073  0.803
2008 Chen KM, Harjes E, Gross PJ, Fahmy A, Lu Y, Shindo K, Harris RS, Matsuo H. Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G. Nature. 452: 116-9. PMID 18288108 DOI: 10.1038/Nature06638  0.492
2008 Schumacher AJ, Haché G, Macduff DA, Brown WL, Harris RS. The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD, and human immunodeficiency virus type 1 restriction. Journal of Virology. 82: 2652-60. PMID 18184715 DOI: 10.1128/Jvi.02391-07  0.837
2007 Chen KM, Martemyanova N, Lu Y, Shindo K, Matsuo H, Harris RS. Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G. Febs Letters. 581: 4761-6. PMID 17869248 DOI: 10.1016/J.Febslet.2007.08.076  0.36
2007 Jónsson SR, LaRue RS, Stenglein MD, Fahrenkrug SC, Andrésdóttir V, Harris RS. The restriction of zoonotic PERV transmission by human APOBEC3G. Plos One. 2: e893. PMID 17849022 DOI: 10.1371/Journal.Pone.0000893  0.802
2007 Mbisa JL, Barr R, Thomas JA, Vandegraaff N, Dorweiler IJ, Svarovskaia ES, Brown WL, Mansky LM, Gorelick RJ, Harris RS, Engelman A, Pathak VK. Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration. Journal of Virology. 81: 7099-110. PMID 17428871 DOI: 10.1128/Jvi.00272-07  0.468
2007 Sekine H, Ferreira RC, Pan-Hammarström Q, Graham RR, Ziemba B, de Vries SS, Liu J, Hippen K, Koeuth T, Ortmann W, Iwahori A, Elliott MK, Offer S, Skon C, Du L, ... ... Harris RS, et al. Role for Msh5 in the regulation of Ig class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 104: 7193-8. PMID 17409188 DOI: 10.1073/Pnas.0700815104  0.687
2007 Cook AJ, Raftery JM, Lau KK, Jessup A, Harris RS, Takeda S, Jolly CJ. DNA-dependent protein kinase inhibits AID-induced antibody gene conversion. Plos Biology. 5: e80. PMID 17355182 DOI: 10.1371/Journal.Pbio.0050080  0.432
2007 Macduff DA, Offer SM, Demorest ZL, Harris RS. Antibody Gene Diversification by Aid-Catalyzed DNA Editing Rna and Dna Editing: Molecular Mechanisms and Their Integration Into Biological Systems. 31-70. DOI: 10.1002/9780470262269.ch2  0.786
2006 Jónsson SR, Haché G, Stenglein MD, Fahrenkrug SC, Andrésdóttir V, Harris RS. Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins. Nucleic Acids Research. 34: 5683-94. PMID 17038330 DOI: 10.1093/Nar/Gkl721  0.73
2006 Stenglein MD, Harris RS. APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism. The Journal of Biological Chemistry. 281: 16837-41. PMID 16648136 DOI: 10.1074/Jbc.M602367200  0.631
2006 Macduff DA, Harris RS. Directed DNA deamination by AID/APOBEC3 in immunity. Current Biology : Cb. 16: R186-9. PMID 16546065 DOI: 10.1016/J.Cub.2006.02.035  0.754
2006 MacDuff DA, Neuberger MS, Harris RS. MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells. Molecular Immunology. 43: 1099-108. PMID 16122802 DOI: 10.1016/J.Molimm.2005.07.024  0.788
2005 Schumacher AJ, Nissley DV, Harris RS. APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast. Proceedings of the National Academy of Sciences of the United States of America. 102: 9854-9. PMID 16000409 DOI: 10.1073/Pnas.0501694102  0.798
2005 Haché G, Liddament MT, Harris RS. The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domain. The Journal of Biological Chemistry. 280: 10920-4. PMID 15647250 DOI: 10.1074/Jbc.M500382200  0.334
2004 Harris RS, Liddament MT. Retroviral restriction by APOBEC proteins. Nature Reviews. Immunology. 4: 868-77. PMID 15516966 DOI: 10.1038/Nri1489  0.459
2004 Liddament MT, Brown WL, Schumacher AJ, Harris RS. APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo. Current Biology : Cb. 14: 1385-91. PMID 15296757 DOI: 10.1016/J.Cub.2004.06.050  0.789
2004 Beale RC, Petersen-Mahrt SK, Watt IN, Harris RS, Rada C, Neuberger MS. Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo. Journal of Molecular Biology. 337: 585-96. PMID 15019779 DOI: 10.1016/J.Jmb.2004.01.046  0.466
2004 Harris RS, Bishop KN, Sheehy AM, Craig HM, Petersen-Mahrt SK, Watt IN, Neuberger MS, Malim MH. Erratum: DNA Deamination Mediates Innate Immunity to Retroviral Infection (Cell (June 13, 2003) 113 (803-809)) Cell. 116. DOI: 10.1016/S0092-8674(04)00163-1  0.36
2004 Harris RS. 87. APOBEC3G and Immunity to retroviruses Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.021  0.417
2003 Conticello SG, Harris RS, Neuberger MS. The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G. Current Biology : Cb. 13: 2009-13. PMID 14614829 DOI: 10.1016/J.Cub.2003.10.034  0.482
2003 Harris RS, Sheehy AM, Craig HM, Malim MH, Neuberger MS. DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses. Nature Immunology. 4: 641-3. PMID 12830140 DOI: 10.1038/Ni0703-641  0.373
2003 Neuberger MS, Harris RS, Di Noia J, Petersen-Mahrt SK. Immunity through DNA deamination. Trends in Biochemical Sciences. 28: 305-12. PMID 12826402 DOI: 10.1016/S0968-0004(03)00111-7  0.412
2003 Harris RS, Bishop KN, Sheehy AM, Craig HM, Petersen-Mahrt SK, Watt IN, Neuberger MS, Malim MH. DNA deamination mediates innate immunity to retroviral infection. Cell. 113: 803-9. PMID 12809610 DOI: 10.1016/S0092-8674(03)00423-9  0.483
2002 Harris RS, Petersen-Mahrt SK, Neuberger MS. RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Molecular Cell. 10: 1247-53. PMID 12453430 DOI: 10.1016/S1097-2765(02)00742-6  0.452
2002 Petersen-Mahrt SK, Harris RS, Neuberger MS. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 418: 99-103. PMID 12097915 DOI: 10.1038/Nature00862  0.416
2002 Harris RS, Sale JE, Petersen-Mahrt SK, Neuberger MS. AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Current Biology : Cb. 12: 435-8. PMID 11882297 DOI: 10.1016/S0960-9822(02)00717-0  0.318
2001 Harris RS, Croom-Carter DS, Rickinson AB, Neuberger MS. Epstein-Barr virus and the somatic hypermutation of immunoglobulin genes in Burkitt's lymphoma cells. Journal of Virology. 75: 10488-92. PMID 11581418 DOI: 10.1128/Jvi.75.21.10488-10492.2001  0.322
2000 McKenzie GJ, Harris RS, Lee PL, Rosenberg SM. The SOS response regulates adaptive mutation Proceedings of the National Academy of Sciences of the United States of America. 97: 6646-6651. PMID 10829077 DOI: 10.1073/Pnas.120161797  0.631
1999 Harris RS, Feng G, Ross KJ, Sidhu R, Thulin C, Longerich S, Szigety SK, Hastings PJ, Winkler ME, Rosenberg SM. Mismatch repair is diminished during stationary-phase mutation Mutation Research - Reviews in Mutation Research. 437: 51-60. PMID 10425389 DOI: 10.1016/S1383-5742(99)00064-2  0.606
1999 Harris RS, Kong Q, Maizels N. Somatic hypermutation and the three R's: repair, replication and recombination. Mutation Research. 436: 157-78. PMID 10095138 DOI: 10.1016/S1383-5742(99)00003-4  0.396
1998 Kong Q, Harris RS, Maizels N. Recombination-based mechanisms for somatic hypermutation Immunological Reviews. 162: 67-76. PMID 9602353 DOI: 10.1111/J.1600-065X.1998.Tb01430.X  0.371
1998 Harris RS, Ross KJ, Lombardo M, Rosenberg SM. Mismatch repair in Escherichia coli cells lacking single-strand exonucleases ExoI, ExoVII, and RecJ. Journal of Bacteriology. 180: 989-993. PMID 9473057 DOI: 10.1128/Jb.180.4.989-993.1998  0.643
1997 Harris RS, Feng G, Ross KJ, Sidhu R, Thulin C, Longerich S, Szigety SK, Winkler ME, Rosenberg SM. Mismatch repair protein MutL becomes limiting during stationary-phase mutation Genes and Development. 11: 2426-2437. PMID 9308969 DOI: 10.1101/Gad.11.18.2426  0.61
1997 Torkelson J, Harris RS, Lombardo MJ, Nagendran J, Thulin C, Rosenberg SM. Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation. The Embo Journal. 16: 3303-3311. PMID 9214645 DOI: 10.1093/Emboj/16.11.3303  0.621
1997 Harris RS, Bull HJ, Rosenberg SM. A direct role for DNA polymerase III in adaptive reversion of a frameshift mutation in Escherichia coli. Mutation Research. 375: 19-24. PMID 9129676 DOI: 10.1016/S0027-5107(96)00244-8  0.647
1997 Harris RS, Torkelson J, Feng G, Lombardo M, Rose KJ, Longerich S, Nagendran J, Sidhu R, Thulin C, Szigety SK, McKenzie G, Bull HJ, Winkler ME, Rosenberg SM. O III A.3 Recombination-dependent stationary-phase mutation: A model for mutagenesis in non-dividing cells Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 379: S17. DOI: 10.1016/S0027-5107(97)82649-8  0.581
1996 Rosenberg SM, Harris RS, Longerich S, Galloway AM. Recombination-dependent mutation in non-dividing cells Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 350: 69-76. PMID 8657199 DOI: 10.1016/0027-5107(95)00092-5  0.644
1995 Rosenberg SM, Harris RS, Torkelson J. Molecular handles on adaptive mutation Molecular Microbiology. 18: 185-189. PMID 8709838 DOI: 10.1111/J.1365-2958.1995.Mmi_18020185.X  0.624
1995 Longerich S, Galloway AM, Harris RS, Wong C, Rosenberg SM. Adaptive mutation sequences reproduced by mismatch repair deficiency Proceedings of the National Academy of Sciences of the United States of America. 92: 12017-12020. PMID 8618835 DOI: 10.1073/Pnas.92.26.12017  0.618
1994 Harris RS, Longerich S, Rosenberg SM. Recombination in Adaptive Mutation Science. 264: 258-260. PMID 8146657 DOI: 10.1126/Science.8146657  0.621
1994 Rosenberg SM, Longerich S, Gee P, Harris RS. Adaptive Mutation by Deletions in Small Mononucleotide Repeats Science. 265: 405-407. PMID 8023163 DOI: 10.1126/Science.8023163  0.642
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