| Year |
Citation |
Score |
| 2020 |
Mahmud F, Deng S, Chen H, Miller DD, Li W. Orally available tubulin inhibitor VERU-111 enhances antitumor efficacy in paclitaxel-resistant lung cancer. Cancer Letters. PMID 32920198 DOI: 10.1016/J.Canlet.2020.09.004 |
0.318 |
|
| 2020 |
Banerjee S, Norman DD, Deng S, Fakayode SO, Lee SC, Parrill AL, Li W, Miller DD, Tigyi GJ. Molecular modelling guided design, synthesis and QSAR analysis of new small molecule non-lipid autotaxin inhibitors. Bioorganic Chemistry. 103: 104188. PMID 32890995 DOI: 10.1016/J.Bioorg.2020.104188 |
0.412 |
|
| 2020 |
Deng S, Krutilina RI, Parke DN, Chen H, Miller DD, Seagroves TN, Li W. Abstract 3071: VERU-111, a novel orally bioavailable tubulin inhibitor, overcomes taxane resistance in metastatic triple-negative breast cancer Cancer Research. 80: 3071-3071. DOI: 10.1158/1538-7445.Am2020-3071 |
0.304 |
|
| 2019 |
Chen H, Deng S, Wang Y, Albadari NG, Kumar G, Ma D, Li W, White SW, Miller DD, Li W. Structure Activity Relationships Study of Novel 6 Aryl-2-Benzoyl-Pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties. Journal of Medicinal Chemistry. PMID 31860298 DOI: 10.1021/Acs.Jmedchem.9B01815 |
0.331 |
|
| 2019 |
Deng S, Krutilina RI, Wang Q, Lin Z, Parke DN, Playa HC, Chen H, Miller DD, Seagroves TN, Li W. An orally available tubulin inhibitor, VERU-111, suppresses triple-negative breast cancer tumor growth and metastasis and bypasses taxane resistance. Molecular Cancer Therapeutics. PMID 31645441 DOI: 10.1158/1535-7163.Mct-19-0536 |
0.303 |
|
| 2019 |
Deng S, Chen H, Krutilina R, Albadari NG, Seagroves TN, Miller DD, Li W. Abstract 4608: Colchicine binding site agents as potent tubulin inhibitors suppressing triple negative breast cancer Cancer Research. 79: 4608-4608. DOI: 10.1158/1538-7445.Am2019-4608 |
0.335 |
|
| 2019 |
Kashyap VK, Hafeez BB, Wang Q, Chauhan N, Nagesh PK, Yallapu MM, Miller DD, Li W, Jaggi M, Chauhan SC. Abstract 3619: Nanoparticle formulation of VERU 111 for pancreatic cancer treatment Cancer Research. 79: 3619-3619. DOI: 10.1158/1538-7445.Am2019-3619 |
0.323 |
|
| 2019 |
Ponnusamy SU, Noto FK, Adedeji BT, He Y, Hwang D, Moody S, Thiyagarajan T, Jamling TY, Miller DD, Narayanan R. Abstract B037: Potential next-generation androgen receptor-targeted therapeutic for enzalutamide-resistant prostate cancer; In vivo characterization in immune-compromised SRG rats Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-B037 |
0.357 |
|
| 2018 |
Hwang DJ, He Y, Ponnusamy S, Mohler ML, Thiyagarajan T, McEwan IJ, Narayanan R, Miller DD. A New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity. Journal of Medicinal Chemistry. PMID 30525603 DOI: 10.1021/Acs.Jmedchem.8B00973 |
0.377 |
|
| 2018 |
Wang Q, Arnst K, Wang Y, Kumar G, Ma D, Chen H, Wu Z, Yang J, White SW, Miller DD, Li W. Structural modification of the 3,4,5-trimethoxyphenyl moiety in the tubulin inhibitor VERU-111 leads to improved antiproliferative activities. Journal of Medicinal Chemistry. PMID 30122035 DOI: 10.1021/Acs.Jmedchem.8B00827 |
0.317 |
|
| 2018 |
Pi M, Kapoor K, Ye R, Hwang DJ, Miller DD, Smith JC, Baudry J, Quarles LD. Computationally identified novel agonists for GPRC6A. Plos One. 13: e0195980. PMID 29684031 DOI: 10.1371/Journal.Pone.0195980 |
0.317 |
|
| 2018 |
Wang Q, Arnst KE, Xue Y, Lei ZN, Ma D, Chen ZS, Miller DD, Li W. Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors. European Journal of Medicinal Chemistry. 149: 211-224. PMID 29501942 DOI: 10.1016/J.Ejmech.2018.02.045 |
0.378 |
|
| 2018 |
Banerjee S, Arnst KE, Wang Y, Kumar G, Deng S, Yang L, Li GB, Yang J, White SW, Li W, Miller DD. Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Anti-Tumor Efficacy. Journal of Medicinal Chemistry. PMID 29406710 DOI: 10.1021/Acs.Jmedchem.7B01858 |
0.333 |
|
| 2018 |
Lin Z, Marepally SR, Goh ESY, Cheng CYS, Janjetovic Z, Kim TK, Miller DD, Postlethwaite AE, Slominski AT, Tuckey RC, Peluso-Iltis C, Rochel N, Li W. Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities. Scientific Reports. 8: 1478. PMID 29367669 DOI: 10.1038/S41598-018-19183-7 |
0.331 |
|
| 2018 |
Deng S, Krutilina R, Wang Q, Seagroves TN, Miller DD, Li W. Abstract 2154: A potent and orally available tubulin inhibitor ABI-231 suppresses triple negative breast cancer tumor growth and metastasis Cancer Research. 78: 2154-2154. DOI: 10.1158/1538-7445.Am2018-2154 |
0.344 |
|
| 2018 |
Getzenberg R, Dalton J, Miller D, Steiner M. MP52-02 A NOVEL ORAL ? AND ? TUBULIN INHIBITOR, VERU-111, HAS POTENT ACTIVITY AGAINST PACLITAXEL SENSITIVE AND RESISTANT PROSTATE CANCER Journal of Urology. 199. DOI: 10.1016/J.Juro.2018.02.1653 |
0.309 |
|
| 2017 |
Arnst KE, Wang Y, Hwang DJ, Xue Y, Costello T, Hamilton D, Chen Q, Yang J, Park F, Dalton JT, Miller DD, Li W. A potent, metabolically stable tubulin inhibitor targets the colchicine binding site and overcomes taxane resistance. Cancer Research. PMID 29180476 DOI: 10.1158/0008-5472.Can-17-0577 |
0.344 |
|
| 2017 |
Ponnusamy S, Coss CC, Thiyagarajan T, Watts K, Hwang DJ, He Y, Selth LA, McEwan IJ, Duke CB, Pagadala J, Singh G, Wake RW, Ledbetter C, Tilley WD, Moldoveanu T, ... ... Miller DD, et al. Novel selective agents for the degradation of androgen receptor variants to treat castration-resistant prostate cancer. Cancer Research. PMID 28978635 DOI: 10.1158/0008-5472.Can-17-0976 |
0.364 |
|
| 2017 |
Park F, Miller D. Role of lysophosphatidic acid and its receptors in the kidney. Physiological Genomics. physiolgenomics.0007. PMID 28939644 DOI: 10.1152/Physiolgenomics.00070.2017 |
0.325 |
|
| 2017 |
He H, Weir RL, Toutounchian JJ, Pagadala J, Steinle JJ, Baudry J, Miller DD, Yates CR. The quinic acid derivative KZ-41 prevents glucose-induced caspase-3 activation in retinal endothelial cells through an IGF-1 receptor dependent mechanism. Plos One. 12: e0180808. PMID 28796787 DOI: 10.1371/Journal.Pone.0180808 |
0.303 |
|
| 2017 |
Yang R, Mondal G, Ness RA, Arnst K, Mundra V, Miller DD, Li W, Mahato RI. Polymer conjugate of a microtubule destabilizer inhibits lung metastatic melanoma. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 28130039 DOI: 10.1016/J.Jconrel.2017.01.028 |
0.31 |
|
| 2017 |
Banerjee S, Norman DD, Lee SC, Parrill AL, Pham TC, Baker DL, Tigyi GG, Miller DD. Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells. Journal of Medicinal Chemistry. PMID 28112925 DOI: 10.1021/Acs.Jmedchem.6B01270 |
0.368 |
|
| 2017 |
Ponnusamy S, Tran QT, Thiyagarajan T, Miller DD, Bridges D, Narayanan R. An estrogen receptor β-selective agonist inhibits non-alcoholic steatohepatitis in preclinical models by regulating bile acid and xenobiotic receptors. Experimental Biology and Medicine (Maywood, N.J.). 1535370216688569. PMID 28092182 DOI: 10.1177/1535370216688569 |
0.314 |
|
| 2017 |
Arnst K, Hwang D, Miller DD, Li W. Abstract 3223: Novel tubulin inhibitor DJ101 targets the colchicine binding site and suppresses melanoma growth and metastasis Cancer Research. 77: 3223-3223. DOI: 10.1158/1538-7445.Am2017-3223 |
0.366 |
|
| 2017 |
Kashyap VK, Hafeez BB, Wang Q, Setua S, Massey A, Ganju A, Yallapu MM, Miller DD, Li W, Jaggi M, Chauhan SC. Abstract 3216: Attenuation of pancreatic tumor growth by a small molecule tubulin inhibitor Cancer Research. 77: 3216-3216. DOI: 10.1158/1538-7445.Am2017-3216 |
0.345 |
|
| 2017 |
Getzenberg R, Ponnusamy S, Thiyagarajan T, Hwang D, He Y, McEwan I, Watt C, Moldoveanu T, Miller D, Narayanan R. Identification and characterization of selective androgen receptor degraders (SARDs) for the treatment of enzalutamide unresponsive and/or resistant prostate cancer European Urology Supplements. 16: e1288-e1289. DOI: 10.1016/J.Juro.2017.02.1777 |
0.32 |
|
| 2016 |
Ponnusamy S, Coss C, Hwang D, McEwan I, Watt C, Thiyagarajan T, Ledbetter C, Patterson A, Grimes B, Wake R, Schwartzberg L, Dalton J, Miller D, Narayanan R. LB-S&T-06 NOVEL DUAL-BINDING SELECTIVE DEGRADERS OF FULL LENGTH AND SPLICE VARIANT ANDROGEN RECEPTORS FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER Journal of Urology. 195. DOI: 10.1016/J.Juro.2016.03.087 |
0.321 |
|
| 2015 |
Hwang DJ, Wang J, Li W, Miller DD. Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents. Acs Medicinal Chemistry Letters. 6: 993-7. PMID 26396686 DOI: 10.1021/Acsmedchemlett.5B00208 |
0.368 |
|
| 2015 |
Banerjee S, Wang J, Pfeffer S, Ma D, Pfeffer LM, Patil SA, Li W, Miller DD. Design, Synthesis and Biological Evaluation of Novel 5H-Chromenopyridines as Potential Anti-Cancer Agents. Molecules (Basel, Switzerland). 20: 17152-17165. PMID 26393554 DOI: 10.3390/Molecules200917152 |
0.311 |
|
| 2015 |
Rao P, Midde NM, Miller D, Chauhan S, Kumar A, Kumar S. Diallyl sulfide: Potential use in novel therapeutic interventions in alcohol, drugs, and disease mediated cellular toxicity by targeting cytochrome P450 2E1. Current Drug Metabolism. PMID 26264202 DOI: 10.2174/1389200216666150812123554 |
0.302 |
|
| 2015 |
Xiao M, Wang J, Lin Z, Lu Y, Li Z, White SW, Miller DD, Li W. Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties. Plos One. 10: e0129807. PMID 26070194 DOI: 10.1371/Journal.Pone.0129807 |
0.389 |
|
| 2015 |
Mundra V, Peng Y, Kumar V, Li W, Miller DD, Mahato RI. Systemic delivery of nanoparticle formulation of novel tubulin inhibitor for treating metastatic melanoma. Drug Delivery and Translational Research. 5: 199-208. PMID 25924699 DOI: 10.1007/S13346-015-0226-2 |
0.305 |
|
| 2015 |
Patil SA, Pfeffer SR, Seibel WL, Pfeffer LM, Miller DD. Identification of imidazoquinoline derivatives as potent antiglioma agents. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 11: 400-6. PMID 25219925 DOI: 10.2174/1573406410666140914162701 |
0.332 |
|
| 2015 |
Lee SC, Fujiwara Y, Liu J, Yue J, Shimizu Y, Norman DD, Wang Y, Tsukahara R, Szabo E, Patil R, Banerjee S, Miller DD, Balazs L, Ghosh MC, Waters CM, et al. Autotaxin and LPA1 and LPA5 receptors exert disparate functions in tumor cells versus the host tissue microenvironment in melanoma invasion and metastasis. Molecular Cancer Research : McR. 13: 174-85. PMID 25158955 DOI: 10.1158/1541-7786.Mcr-14-0263 |
0.339 |
|
| 2015 |
Xiao M, Wang J, Lu Y, Miller DD, Li W. Abstract B20: Design, synthesis and SAR studies of novel survivin inhibitors with potent antiproliferative properties Cancer Research. 75. DOI: 10.1158/1538-7445.Mel2014-B20 |
0.384 |
|
| 2015 |
Lee S, Fujiwara Y, Liu J, Yue J, Tsukahara R, Szabo E, Patil R, Miller DD, Balazs L, Oravecz T, Tigyi GJ. Abstract B28: Autotaxin, LPA1 and LPA5 receptors in the tumor microenvironment determine melanoma invasion and metastasis Cancer Research. 75. DOI: 10.1158/1538-7445.Chtme14-B28 |
0.344 |
|
| 2015 |
Wang J, Xiao M, Miller DD, Li W. Abstract 3659: Target validation and structural optimization of selective small molecule survivin inhibitors as potential anti-cancer agents Cancer Research. 75: 3659-3659. DOI: 10.1158/1538-7445.Am2015-3659 |
0.392 |
|
| 2014 |
McMillan JE, Bukiya AN, Terrell CL, Patil SA, Miller DD, Dopico AM, Parrill AL. Multi-generational pharmacophore modeling for ligands to the cholane steroid-recognition site in the β₁ modulatory subunit of the BKCa channel. Journal of Molecular Graphics & Modelling. 54: 174-83. PMID 25459769 DOI: 10.1016/J.Jmgm.2014.10.008 |
0.312 |
|
| 2014 |
Leblanc R, Lee SC, David M, Bordet JC, Norman DD, Patil R, Miller D, Sahay D, Ribeiro J, Clézardin P, Tigyi GJ, Peyruchaud O. Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone. Blood. 124: 3141-50. PMID 25277122 DOI: 10.1182/Blood-2014-04-568683 |
0.321 |
|
| 2014 |
Lu Y, Chen J, Wang J, Li CM, Ahn S, Barrett CM, Dalton JT, Li W, Miller DD. Design, synthesis, and biological evaluation of stable colchicine binding site tubulin inhibitors as potential anticancer agents. Journal of Medicinal Chemistry. 57: 7355-66. PMID 25122533 DOI: 10.1021/Jm500764V |
0.349 |
|
| 2014 |
Patil R, Fells JI, Szabó E, Lim KG, Norman DD, Balogh A, Patil S, Strobos J, Miller DD, Tigyi GJ. Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor. Journal of Medicinal Chemistry. 57: 7136-40. PMID 25100502 DOI: 10.1021/Jm5007116 |
0.414 |
|
| 2014 |
Jiang Y, Pagadala J, Miller DD, Steinle JJ. Insulin-like growth factor-1 binding protein 3 (IGFBP-3) promotes recovery from trauma-induced expression of inflammatory and apoptotic factors in retina. Cytokine. 70: 115-9. PMID 25082650 DOI: 10.1016/J.Cyto.2014.07.004 |
0.31 |
|
| 2014 |
Narayanan R, Ahn S, Cheney MD, Yepuru M, Miller DD, Steiner MS, Dalton JT. Selective androgen receptor modulators (SARMs) negatively regulate triple-negative breast cancer growth and epithelial:mesenchymal stem cell signaling. Plos One. 9: e103202. PMID 25072326 DOI: 10.1371/Journal.Pone.0103202 |
0.311 |
|
| 2014 |
Morales-Lázaro SL, Serrano-Flores B, Llorente I, Hernández-GarcÃa E, González-RamÃrez R, Banerjee S, Miller D, Gududuru V, Fells J, Norman D, Tigyi G, Escalante-Alcalde D, Rosenbaum T. Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs. The Journal of Biological Chemistry. 289: 24079-90. PMID 25035428 DOI: 10.1074/Jbc.M114.572503 |
0.368 |
|
| 2014 |
Thompson KE, Zeng K, Wilson CM, Gaber MW, Miller DD, Yates CR. Quinic acid derivative KZ-41 exhibits radiomitigating activity in preclinical models of radiation injury. Drug Development Research. 75: 29-36. PMID 24648047 DOI: 10.1002/Ddr.21164 |
0.664 |
|
| 2014 |
Patil R, Hosni-Ahmed A, Jones TS, Patil SA, Asres LB, Wang X, Yates RC, Geisert EE, Miller DD. Synthesis and in vitro evaluation of novel 1,2,3,4-tetrahydroisoquinoline derivatives as potent antiglioma agents. Anti-Cancer Agents in Medicinal Chemistry. 14: 473-82. PMID 24533653 DOI: 10.2174/18715206113139990328 |
0.343 |
|
| 2014 |
Fells JI, Lee SC, Norman DD, Tsukahara R, Kirby JR, Nelson S, Seibel W, Papoian R, Patil R, Miller DD, Parrill AL, Pham TC, Baker DL, Bittman R, Tigyi G. Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif. The Febs Journal. 281: 1017-28. PMID 24314137 DOI: 10.1111/Febs.12674 |
0.324 |
|
| 2014 |
Morales-Lázaro SL, Serrano-Flores B, Llorente I, Hernández-García E, González-Ramírez R, Banerjee S, Miller D, Gududuru V, Fells J, Norman D, Tigyi G, Escalante-Alcalde D, Rosenbaum T. Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs. Journal of Biological Chemistry. 289: 33876-33876. DOI: 10.1074/Jbc.A114.572503 |
0.307 |
|
| 2013 |
Yepuru M, Wu Z, Barrett C, Kim J, Penning TM, Steiner MS, Miller DD, Dalton JT. Aldo-keto reductase (AKR) 1C3 as an androgen receptor coactivator. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 100. PMID 28137027 DOI: 10.1200/Jco.2013.31.6_Suppl.100 |
0.336 |
|
| 2013 |
Narayanan R, Yepuru M, Coss CC, Wu Z, Bauler MN, Barrett CM, Mohler ML, Wang Y, Kim J, Snyder LM, He Y, Levy N, Miller DD, Dalton JT. Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation. Plos One. 8: e83380. PMID 24386191 DOI: 10.1371/Journal.Pone.0083380 |
0.346 |
|
| 2013 |
Patil SA, Patil R, Pfeffer LM, Miller DD. Chromenes: potential new chemotherapeutic agents for cancer. Future Medicinal Chemistry. 5: 1647-60. PMID 24047270 DOI: 10.4155/Fmc.13.126 |
0.304 |
|
| 2013 |
Yepuru M, Wu Z, Kulkarni A, Yin F, Barrett CM, Kim J, Steiner MS, Miller DD, Dalton JT, Narayanan R. Steroidogenic enzyme AKR1C3 is a novel androgen receptor-selective coactivator that promotes prostate cancer growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 5613-25. PMID 23995860 DOI: 10.1158/1078-0432.Ccr-13-1151 |
0.335 |
|
| 2013 |
Jiang Y, Liu L, Pagadala J, Miller DD, Steinle JJ. Compound 49b protects against blast-induced retinal injury. Journal of Neuroinflammation. 10: 96. PMID 23899290 DOI: 10.1186/1742-2094-10-96 |
0.325 |
|
| 2013 |
Fells JI, Lee SC, Fujiwara Y, Norman DD, Lim KG, Tsukahara R, Liu J, Patil R, Miller DD, Kirby RJ, Nelson S, Seibel W, Papoian R, Parrill AL, Baker DL, et al. Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface. Molecular Pharmacology. 84: 415-24. PMID 23793291 DOI: 10.1124/Mol.113.087080 |
0.396 |
|
| 2013 |
Xiao M, Ahn S, Wang J, Chen J, Miller DD, Dalton JT, Li W. Discovery of 4-Aryl-2-benzoyl-imidazoles as tubulin polymerization inhibitor with potent antiproliferative properties. Journal of Medicinal Chemistry. 56: 3318-29. PMID 23547728 DOI: 10.1021/Jm4001117 |
0.372 |
|
| 2013 |
Xiao M, Ahn S, Chen J, Wang J, Miller DD, Dalton JT, Li W. Abstract 5684: Target tubulin polymerization with novel reverse ABI analogs interacting with the colchicine binding site. Cancer Research. 73: 5684-5684. DOI: 10.1158/1538-7445.Am2013-5684 |
0.384 |
|
| 2013 |
Tigyi G, Fujiwara Y, Lee S, Liu J, Patil R, Gupte R, Miller DD, Oravecz T, Balazs L. Abstract 3884: Targeting ATX and LPA receptors melanoma invasion and metastasis. Cancer Research. 73: 3884-3884. DOI: 10.1158/1538-7445.Am2013-3884 |
0.788 |
|
| 2013 |
Lu Y, Narayanan R, Wang J, Li W, Yepuru M, Liu L, Loveless VS, Miller DD. Abstract 1320: Effects of selective androgen-receptor and estrogen-receptor modulators on telomerase activity in melanoma and prostate cancer cells. Cancer Research. 73: 1320-1320. DOI: 10.1158/1538-7445.Am2013-1320 |
0.359 |
|
| 2012 |
Patil SA, Patil R, Miller DD. Indole molecules as inhibitors of tubulin polymerization: potential new anticancer agents. Future Medicinal Chemistry. 4: 2085-115. PMID 23157240 DOI: 10.4155/Fmc.12.141 |
0.306 |
|
| 2012 |
Kiss GN, Fells JI, Gupte R, Lee SC, Liu J, Nusser N, Lim KG, Ray RM, Lin FT, Parrill AL, Sümegi B, Miller DD, Tigyi G. Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Molecular Pharmacology. 82: 1162-73. PMID 22968304 DOI: 10.1124/Mol.112.079699 |
0.806 |
|
| 2012 |
Chen J, Ahn S, Wang J, Lu Y, Dalton JT, Miller DD, Li W. Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents. Journal of Medicinal Chemistry. 55: 7285-9. PMID 22783954 DOI: 10.1021/Jm300564B |
0.354 |
|
| 2012 |
Li CM, Lu Y, Chen J, Costello TA, Narayanan R, Dalton MN, Snyder LM, Ahn S, Li W, Miller DD, Dalton JT. Orally bioavailable tubulin antagonists for paclitaxel-refractory cancer. Pharmaceutical Research. 29: 3053-63. PMID 22760659 DOI: 10.1007/S11095-012-0814-5 |
0.332 |
|
| 2012 |
Giddabasappa A, Eswaraka JR, Barrett CM, Bauler MN, Wu Z, Yepuru M, Miller DD, Dalton JT. β-LGND2, an ERβ selective agonist, inhibits pathologic retinal neovascularization. Investigative Ophthalmology & Visual Science. 53: 5066-75. PMID 22714897 DOI: 10.1167/Iovs.12-9627 |
0.306 |
|
| 2012 |
Patil SA, Wang J, Li XS, Chen J, Jones TS, Hosni-Ahmed A, Patil R, Seibel WL, Li W, Miller DD. New substituted 4H-chromenes as anticancer agents. Bioorganic & Medicinal Chemistry Letters. 22: 4458-61. PMID 22608389 DOI: 10.1016/J.Bmcl.2012.04.074 |
0.353 |
|
| 2012 |
Mohler ML, Coss CC, Duke CB, Patil SA, Miller DD, Dalton JT. Androgen receptor antagonists: a patent review (2008-2011). Expert Opinion On Therapeutic Patents. 22: 541-65. PMID 22583332 DOI: 10.1517/13543776.2012.682571 |
0.353 |
|
| 2012 |
Yang J, Ahn S, Wu Z, Hwang DJ, Miller DD, Dalton JT. Pharmacokinetics, pharmacodynamics and metabolism of a novel anticancer agent for prostate cancer. International Journal of Oncology. 41: 337-44. PMID 22576690 DOI: 10.3892/Ijo.2012.1442 |
0.302 |
|
| 2012 |
Kim TK, Wang J, Janjetovic Z, Chen J, Tuckey RC, Nguyen MN, Tang EK, Miller D, Li W, Slominski AT. Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength. Molecular and Cellular Endocrinology. 361: 143-52. PMID 22546549 DOI: 10.1016/J.Mce.2012.04.001 |
0.317 |
|
| 2012 |
Danquah M, Duke CB, Patil R, Miller DD, Mahato RI. Combination therapy of antiandrogen and XIAP inhibitor for treating advanced prostate cancer. Pharmaceutical Research. 29: 2079-91. PMID 22451249 DOI: 10.1007/S11095-012-0737-1 |
0.312 |
|
| 2012 |
Wang XD, Freeman NE, Patil R, Patil SA, Mitra S, Orr WE, Abner CW, Yates CR, Miller DD, Geisert EE. EDL-291, a novel isoquinoline, presents antiglioblastoma effects in vitro and in vivo. Anti-Cancer Drugs. 23: 494-504. PMID 22391460 DOI: 10.1097/Cad.0B013E328351Ee4F |
0.315 |
|
| 2012 |
Coss CC, Jones A, Parke DN, Narayanan R, Barrett CM, Kearbey JD, Veverka KA, Miller DD, Morton RA, Steiner MS, Dalton JT. Preclinical characterization of a novel diphenyl benzamide selective ERα agonist for hormone therapy in prostate cancer. Endocrinology. 153: 1070-81. PMID 22294742 DOI: 10.1210/En.2011-1608 |
0.304 |
|
| 2012 |
Gotoh M, Fujiwara Y, Yue J, Liu J, Lee S, Fells J, Uchiyama A, Murakami-Murofushi K, Kennel S, Wall J, Patil R, Gupte R, Balazs L, Miller DD, Tigyi GJ. Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis. Biochemical Society Transactions. 40: 31-6. PMID 22260662 DOI: 10.1042/Bst20110608 |
0.785 |
|
| 2012 |
Ahn S, Li C, Barrett CM, Chen J, Li W, Lu Y, Miller DD, Dalton JT. Abstract 2788: GTx-230: an orally available novel tubulin inhibitor that disrupts tumor vasculature and displays single-agent antitumor efficacy in multidrug-resistant prostate cancer with less neurotoxicity Cancer Research. 72: 2788-2788. DOI: 10.1158/1538-7445.Am2012-2788 |
0.367 |
|
| 2011 |
Zeng K, Thompson KE, Presley CS, Miller DD, Yates CR. Preclinical pharmacokinetics of the radiomitigator KZ-41 in rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 41: 1006-12. PMID 21864202 DOI: 10.3109/00498254.2011.603387 |
0.665 |
|
| 2011 |
Chen J, Li CM, Wang J, Ahn S, Wang Z, Lu Y, Dalton JT, Miller DD, Li W. Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization. Bioorganic & Medicinal Chemistry. 19: 4782-95. PMID 21775150 DOI: 10.1016/J.Bmc.2011.06.084 |
0.394 |
|
| 2011 |
Li CM, Chen J, Lu Y, Narayanan R, Parke DN, Li W, Ahn S, Miller DD, Dalton JT. Pharmacokinetic optimization of 4-substituted methoxybenzoyl-aryl-thiazole and 2-aryl-4-benzoyl-imidazole for improving oral bioavailability. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 1833-9. PMID 21742898 DOI: 10.1124/Dmd.110.036616 |
0.314 |
|
| 2011 |
Lu Y, Li CM, Wang Z, Chen J, Mohler ML, Li W, Dalton JT, Miller DD. Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents. Journal of Medicinal Chemistry. 54: 4678-93. PMID 21557538 DOI: 10.1021/Jm2003427 |
0.367 |
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| 2011 |
Duke CB, Jones A, Bohl CE, Dalton JT, Miller DD. Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets. Journal of Medicinal Chemistry. 54: 3973-6. PMID 21506597 DOI: 10.1021/Jm2000097 |
0.371 |
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| 2011 |
Gupte R, Patil R, Liu J, Wang Y, Lee SC, Fujiwara Y, Fells J, Bolen AL, Emmons-Thompson K, Yates CR, Siddam A, Panupinthu N, Pham TC, Baker DL, Parrill AL, ... ... Miller DD, et al. Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity. Chemmedchem. 6: 922-35. PMID 21465666 DOI: 10.1002/Cmdc.201000425 |
0.811 |
|
| 2011 |
Ahn S, Kearbey JD, Li CM, Duke CB, Miller DD, Dalton JT. Biotransformation of a novel antimitotic agent, I-387, by mouse, rat, dog, monkey, and human liver microsomes and in vivo pharmacokinetics in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 636-43. PMID 21233217 DOI: 10.1124/Dmd.110.036673 |
0.317 |
|
| 2011 |
Li CM, Wang Z, Lu Y, Ahn S, Narayanan R, Kearbey JD, Parke DN, Li W, Miller DD, Dalton JT. Biological activity of 4-substituted methoxybenzoyl-aryl-thiazole: an active microtubule inhibitor. Cancer Research. 71: 216-24. PMID 21084278 DOI: 10.1158/0008-5472.Can-10-1725 |
0.371 |
|
| 2011 |
Zmijewski MA, Li W, Chen J, Kim TK, Zjawiony JK, Sweatman TW, Miller DD, Slominski AT. Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity. Steroids. 76: 193-203. PMID 21070794 DOI: 10.1016/J.Steroids.2010.10.009 |
0.349 |
|
| 2011 |
Ahn S, Hwang DJ, Barrett CM, Yang J, Duke CB, Miller DD, Dalton JT. A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer. Cancer Chemotherapy and Pharmacology. 67: 293-304. PMID 20383708 DOI: 10.1007/S00280-010-1319-8 |
0.361 |
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| 2011 |
Li W, Chen J, Wang Z, Li C, Lu Y, Dalton JT, Miller D. Abstract 1350: Novel ABI analogs target the colchicine site in tubulin and overcome multidrug resistance in metastatic melanoma Cancer Research. 71: 1350-1350. DOI: 10.1158/1538-7445.Am2011-1350 |
0.358 |
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| 2011 |
Pagadala J, Williams-Guy K, Nooh MM, Steinle JJ, Miller DD. Beta-adrenergic receptor signaling by the isomers of isoproterenol and like drugs in retinal endothelial cells and Müller cells Medchemcomm. 2: 726-730. DOI: 10.1039/C0Md00227E |
0.368 |
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| 2011 |
Patil R, Patil S, Wang X, Ma F, Orr WE, Li W, Yates CR, Geisert EE, Miller DD. Synthesis and evaluation of new 1,2,3,4-tetrahydroisoquinoline analogs as antiglioma agents Medicinal Chemistry Research. 20: 131-137. DOI: 10.1007/S00044-010-9356-8 |
0.354 |
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| 2010 |
Gupte R, Siddam A, Lu Y, Li W, Fujiwara Y, Panupinthu N, Pham TC, Baker DL, Parrill AL, Gotoh M, Murakami-Murofushi K, Kobayashi S, Mills GB, Tigyi G, Miller DD. Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid. Bioorganic & Medicinal Chemistry Letters. 20: 7525-8. PMID 21051230 DOI: 10.1016/J.Bmcl.2010.09.115 |
0.798 |
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| 2010 |
Chen J, Wang Z, Li CM, Lu Y, Vaddady PK, Meibohm B, Dalton JT, Miller DD, Li W. Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. Journal of Medicinal Chemistry. 53: 7414-27. PMID 20919720 DOI: 10.1021/Jm100884B |
0.385 |
|
| 2010 |
Ahn S, Duke CB, Barrett CM, Hwang DJ, Li CM, Miller DD, Dalton JT. I-387, a novel antimitotic indole, displays a potent in vitro and in vivo antitumor activity with less neurotoxicity. Molecular Cancer Therapeutics. 9: 2859-68. PMID 20829196 DOI: 10.1158/1535-7163.Mct-10-0399 |
0.366 |
|
| 2010 |
Li CM, Narayanan R, Lu Y, Hurh E, Coss CC, Barrett CM, Miller DD, Dalton JT. 2-Arylthiazolidine-4-carboxylic acid amides (ATCAA) target dual pathways in cancer cells: 5'-AMP-activated protein kinase (AMPK)/mTOR and PI3K/Akt/mTOR pathways. International Journal of Oncology. 37: 1023-30. PMID 20811725 DOI: 10.3892/Ijo_00000754 |
0.361 |
|
| 2010 |
Li CM, Lu Y, Narayanan R, Miller DD, Dalton JT. Drug metabolism and pharmacokinetics of 4-substituted methoxybenzoyl-aryl-thiazoles. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 2032-9. PMID 20675405 DOI: 10.1124/Dmd.110.034348 |
0.322 |
|
| 2010 |
Nassr M, Wang X, Mitra S, Freeman-Anderson NE, Patil R, Yates CR, Miller DD, Geisert EE. Treating retinoblastoma in tissue culture and in a rat model with a novel isoquinoline derivative. Investigative Ophthalmology & Visual Science. 51: 3813-9. PMID 20570997 DOI: 10.1167/Iovs.09-5042 |
0.306 |
|
| 2010 |
Giddabasappa A, Bauler MN, Barrett CM, Coss CC, Wu Z, Miller DD, Dalton JT, Eswaraka JR. GTx-822, an ER{beta}-selective agonist, protects retinal pigment epithelium (ARPE-19) from oxidative stress by activating MAPK and PI3-K pathways. Investigative Ophthalmology & Visual Science. 51: 5934-42. PMID 20554624 DOI: 10.1167/Iovs.10-5630 |
0.302 |
|
| 2010 |
Jones A, Hwang DJ, Duke CB, He Y, Siddam A, Miller DD, Dalton JT. Nonsteroidal selective androgen receptor modulators enhance female sexual motivation. The Journal of Pharmacology and Experimental Therapeutics. 334: 439-48. PMID 20444881 DOI: 10.1124/Jpet.110.168880 |
0.348 |
|
| 2010 |
Mohler ML, Narayanan R, Coss CC, Hu K, He Y, Wu Z, Hong SS, Hwang DJ, Miller DD, Dalton JT. Estrogen receptor beta selective nonsteroidal estrogens: seeking clinical indications. Expert Opinion On Therapeutic Patents. 20: 507-34. PMID 20302450 DOI: 10.1517/13543771003657164 |
0.35 |
|
| 2010 |
Mohler ML, He Y, Wu Z, Hong SS, Miller DD. Non-steroidal glucocorticoid receptor antagonists: the race to replace RU-486 for anti-glucocorticoid therapy. Expert Opinion On Therapeutic Patents. 17: 59-81. PMID 20144063 DOI: 10.1517/13543776.17.1.59 |
0.302 |
|
| 2010 |
Narayanan R, Yepuru M, Szafran AT, Szwarc M, Bohl CE, Young NL, Miller DD, Mancini MA, Dalton JT. Discovery and mechanistic characterization of a novel selective nuclear androgen receptor exporter for the treatment of prostate cancer. Cancer Research. 70: 842-51. PMID 20068182 DOI: 10.1158/0008-5472.Can-09-3206 |
0.359 |
|
| 2010 |
Li F, Lu Y, Li W, Miller DD, Mahato RI. Synthesis, formulation and in vitro evaluation of a novel microtubule destabilizer, SMART-100. Journal of Controlled Release : Official Journal of the Controlled Release Society. 143: 151-8. PMID 20060430 DOI: 10.1016/J.Jconrel.2009.12.028 |
0.327 |
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| 2010 |
Lu Y, Wang Z, Li CM, Chen J, Dalton JT, Li W, Miller DD. Synthesis, in vitro structure-activity relationship, and in vivo studies of 2-arylthiazolidine-4-carboxylic acid amides as anticancer agents. Bioorganic & Medicinal Chemistry. 18: 477-95. PMID 20056548 DOI: 10.1016/J.Bmc.2009.12.020 |
0.392 |
|
| 2010 |
Kim TK, Chen J, Li W, Zjawiony J, Miller D, Janjetovic Z, Tuckey RC, Slominski A. A new steroidal 5,7-diene derivative, 3beta-hydroxyandrosta-5,7-diene-17beta-carboxylic acid, shows potent anti-proliferative activity. Steroids. 75: 230-9. PMID 20025893 DOI: 10.1016/J.Steroids.2009.12.004 |
0.34 |
|
| 2010 |
Li W, Wang Z, Chen J, Lu Y, Li C, Dalton JT, Miller D. Abstract 730: Targeting colchicine binding site in tubulin for the treatment of advanced melanoma Cancer Research. 70: 730-730. DOI: 10.1158/1538-7445.Am10-730 |
0.32 |
|
| 2009 |
Kearbey JD, Gao W, Fisher SJ, Wu D, Miller DD, Dalton JT. Effects of selective androgen receptor modulator (SARM) treatment in osteopenic female rats. Pharmaceutical Research. 26: 2471-7. PMID 19728047 DOI: 10.1007/S11095-009-9962-7 |
0.351 |
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| 2009 |
Zeng K, Thompson KE, Yates CR, Miller DD. Synthesis and biological evaluation of quinic acid derivatives as anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. 19: 5458-60. PMID 19674895 DOI: 10.1016/J.Bmcl.2009.07.096 |
0.694 |
|
| 2009 |
Wang Z, Lu Y, Seibel W, Miller DD, Li W. Identifying novel molecular structures for advanced melanoma by ligand-based virtual screening. Journal of Chemical Information and Modeling. 49: 1420-7. PMID 19445498 DOI: 10.1021/Ci800445A |
0.334 |
|
| 2009 |
Lu Y, Li CM, Wang Z, Ross CR, Chen J, Dalton JT, Li W, Miller DD. Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships. Journal of Medicinal Chemistry. 52: 1701-11. PMID 19243174 DOI: 10.1021/Jm801449A |
0.404 |
|
| 2009 |
Zmijewski MA, Li W, Zjawiony JK, Sweatman TW, Chen J, Miller DD, Slominski AT. Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3beta, 17alpha, 20-triol and their bioactivity in melanoma cells. Steroids. 74: 218-28. PMID 19028513 DOI: 10.1016/J.Steroids.2008.10.017 |
0.315 |
|
| 2009 |
Jones A, Chen J, Hwang DJ, Miller DD, Dalton JT. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 150: 385-95. PMID 18772237 DOI: 10.1210/En.2008-0674 |
0.305 |
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| 2009 |
Yang J, Wu Z, Wu D, Darby MV, Hong SS, Miller DD, Dalton JT. Pharmacokinetics, biodistribution and metabolism of a novel selective androgen receptor modulator designed for prostate cancer imaging International Journal of Oncology. 36: 213-222. DOI: 10.3892/Ijo_00000492 |
0.352 |
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| 2008 |
Narayanan R, Mohler ML, Bohl CE, Miller DD, Dalton JT. Selective androgen receptor modulators in preclinical and clinical development. Nuclear Receptor Signaling. 6: e010. PMID 19079612 DOI: 10.1621/Nrs.06010 |
0.329 |
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| 2008 |
Zmijewski MA, Li W, Zjawiony JK, Sweatman TW, Chen J, Miller DD, Slominski AT. Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. 7: 1570-6. PMID 19037511 DOI: 10.1039/B809005J |
0.327 |
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| 2008 |
Khandoga AL, Fujiwara Y, Goyal P, Pandey D, Tsukahara R, Bolen A, Guo H, Wilke N, Liu J, Valentine WJ, Durgam GG, Miller DD, Jiang G, Prestwich GD, Tigyi G, et al. Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin. Platelets. 19: 415-27. PMID 18925509 DOI: 10.1080/09537100802220468 |
0.798 |
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| 2008 |
Bohl CE, Wu Z, Chen J, Mohler ML, Yang J, Hwang DJ, Mustafa S, Miller DD, Bell CE, Dalton JT. Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators. Bioorganic & Medicinal Chemistry Letters. 18: 5567-70. PMID 18805694 DOI: 10.1016/J.Bmcl.2008.09.002 |
0.358 |
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| 2008 |
Narayanan R, Coss CC, Yepuru M, Kearbey JD, Miller DD, Dalton JT. Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways. Molecular Endocrinology (Baltimore, Md.). 22: 2448-65. PMID 18801930 DOI: 10.1210/Me.2008-0160 |
0.34 |
|
| 2008 |
Kang GS, Wang XD, Mohler ML, Kirichenko OV, Patil R, Orr WE, Miller DD, Geisert EE. Effects, in an in-vivo model system, of 1,2,3,4-tetrahydroisoquinoline on glioma. Anti-Cancer Drugs. 19: 859-70. PMID 18766000 DOI: 10.1097/Cad.0B013E32830D5887 |
0.762 |
|
| 2008 |
Chen J, Wang Z, Lu Y, Dalton JT, Miller DD, Li W. Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma. Bioorganic & Medicinal Chemistry Letters. 18: 3183-7. PMID 18477505 DOI: 10.1016/J.Bmcl.2008.04.073 |
0.368 |
|
| 2008 |
Patil S, Bukiya AN, Li W, Dopico AM, Miller D. Design and synthesis of hydroxy-alkynoic acids and their methyl esters as novel activators of BK channels Bioorganic and Medicinal Chemistry Letters. 18: 3427-3430. PMID 18462939 DOI: 10.1016/J.Bmcl.2008.03.080 |
0.312 |
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| 2008 |
Ramagiri S, Gupte R, Rakov I, Yates CR, Miller DD. Quantitative chiral analysis of phthaloylglutamic acid and related analogs by a single ratio kinetic method using electrospray ionization and matrix-assisted laser desorption techniques. Rapid Communications in Mass Spectrometry : Rcm. 22: 639-46. PMID 18247407 DOI: 10.1002/Rcm.3405 |
0.758 |
|
| 2007 |
Li W, Lu Y, Wang Z, Dalton JT, Miller DD. Synthesis and antiproliferative activity of thiazolidine analogs for melanoma. Bioorganic & Medicinal Chemistry Letters. 17: 4113-7. PMID 17561392 DOI: 10.1016/J.Bmcl.2007.05.059 |
0.392 |
|
| 2007 |
Hao F, Tan M, Xu X, Han J, Miller DD, Tigyi G, Cui MZ. Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha. Biochimica Et Biophysica Acta. 1771: 883-92. PMID 17531530 DOI: 10.1016/J.Bbalip.2007.04.010 |
0.353 |
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| 2007 |
Deng W, Shuyu E, Tsukahara R, Valentine WJ, Durgam G, Gududuru V, Balazs L, Manickam V, Arsura M, VanMiddlesworth L, Johnson LR, Parrill AL, Miller DD, Tigyi G. The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury. Gastroenterology. 132: 1834-51. PMID 17484878 DOI: 10.1053/J.Gastro.2007.03.038 |
0.777 |
|
| 2007 |
Bohl CE, Wu Z, Miller DD, Bell CE, Dalton JT. Crystal structure of the T877A human androgen receptor ligand-binding domain complexed to cyproterone acetate provides insight for ligand-induced conformational changes and structure-based drug design. The Journal of Biological Chemistry. 282: 13648-55. PMID 17311914 DOI: 10.1074/Jbc.M611711200 |
0.342 |
|
| 2006 |
Mohler ML, Kang GS, Hong SS, Patil R, Kirichenko OV, Li W, Rakov IM, Geisert EE, Miller DD. Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues. Journal of Medicinal Chemistry. 49: 5845-8. PMID 16970409 DOI: 10.1021/Jm060020X |
0.778 |
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| 2006 |
Salazar-Bookaman MM, Miller DD, Patil PN. Antagonism by imidazoline-type drugs of muscarinic and other receptors in the guinea-pig ileum. Autonomic & Autacoid Pharmacology. 26: 267-73. PMID 16879492 DOI: 10.1111/J.1474-8673.2006.00355.X |
0.318 |
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| 2006 |
Bavadekar SA, Ma G, Mustafa SM, Moore BM, Miller DD, Feller DR. Tethered yohimbine analogs as selective human alpha2C-adrenergic receptor ligands. The Journal of Pharmacology and Experimental Therapeutics. 319: 739-48. PMID 16873606 DOI: 10.1124/Jpet.106.105981 |
0.348 |
|
| 2006 |
Hwang DJ, Yang J, Xu H, Rakov IM, Mohler ML, Dalton JT, Miller DD. Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer. Bioorganic & Medicinal Chemistry. 14: 6525-38. PMID 16828557 DOI: 10.1016/J.Bmc.2006.06.019 |
0.369 |
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| 2006 |
Perera MA, Yin D, Wu D, Chan KK, Miller DD, Dalton J. In vivo metabolism and final disposition of a novel nonsteroidal androgen in rats and dogs. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1713-21. PMID 16815963 DOI: 10.1124/Dmd.106.009985 |
0.327 |
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| 2006 |
Yang J, Bohl CE, Nair VA, Mustafa SM, Seoung SH, Miller DD, Dalton JT. Preclinical pharmacology of a nonsteroidal ligand for androgen receptor-mediated imaging of prostate cancer Journal of Pharmacology and Experimental Therapeutics. 317: 402-408. PMID 16434567 DOI: 10.1124/Jpet.105.094334 |
0.354 |
|
| 2006 |
Nikulin VI, Rakov IM, De Los Angeles JE, Mehta RC, Boyd LY, Feller DR, Miller DD. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diols as novel affinity and photoaffinity probes for beta-adrenoceptor subtypes. Bioorganic & Medicinal Chemistry. 14: 1684-97. PMID 16431119 DOI: 10.1016/J.Bmc.2005.12.027 |
0.334 |
|
| 2006 |
Wu D, Wu Z, Yang J, Nair VA, Miller DD, Dalton JT. Pharmacokinetics and metabolism of a selective androgen receptor modulator in rats: Implication of molecular properties and intensive metabolic profile to investigate ideal pharmacokinetic characteristics of a propanamide in preclinical study Drug Metabolism and Disposition. 34: 483-494. PMID 16381665 DOI: 10.1124/Dmd.105.006643 |
0.33 |
|
| 2006 |
Gududuru V, Zeng K, Tsukahara R, Makarova N, Fujiwara Y, Pigg KR, Baker DL, Tigyi G, Miller DD. Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors. Bioorganic & Medicinal Chemistry Letters. 16: 451-6. PMID 16290140 DOI: 10.1016/J.Bmcl.2005.08.096 |
0.751 |
|
| 2006 |
Durgam GG, Tsukahara R, Makarova N, Walker MD, Fujiwara Y, Pigg KR, Baker DL, Sardar VM, Parrill AL, Tigyi G, Miller DD. Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands. Bioorganic & Medicinal Chemistry Letters. 16: 633-40. PMID 16263282 DOI: 10.1016/J.Bmcl.2005.10.031 |
0.787 |
|
| 2006 |
Goyal P, Durgam G, Wilke N, Miller D, Tigyi G, Siess W. We-P11:210 Evaluation of novel phosphatidic acid derivatives as antagonists of platelet activation induced by the plaque lipid lysophosphatidic acid Atherosclerosis Supplements. 7: 392. DOI: 10.1016/S1567-5688(06)81564-3 |
0.782 |
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| 2005 |
Gao W, Wu Z, Bohl CE, Yang J, Miller DD, Dalton JT. Characterization of the in vitro metabolism of selective androgen receptor modulator using human, rat, and dog liver enzyme preparations. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 243-53. PMID 16272404 DOI: 10.1124/Dmd.105.007112 |
0.302 |
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| 2005 |
Chen J, Hwang DJ, Chung K, Bohl CE, Fisher SJ, Miller DD, Dalton JT. In vitro and in vivo structure-activity relationships of novel androgen receptor ligands with multiple substituents in the B-ring. Endocrinology. 146: 5444-54. PMID 16166218 DOI: 10.1210/En.2005-0732 |
0.421 |
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| 2005 |
Hong SS, Bavadekar SA, Lee SI, Patil PN, Lalchandani SG, Feller DR, Miller DD. Bioisosteric phentolamine analogs as potent alpha-adrenergic antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 4691-5. PMID 16153828 DOI: 10.1016/J.Bmcl.2005.07.083 |
0.347 |
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| 2005 |
Bohl CE, Miller DD, Chen J, Bell CE, Dalton JT. Structural basis for accommodation of nonsteroidal ligands in the androgen receptor. The Journal of Biological Chemistry. 280: 37747-54. PMID 16129672 DOI: 10.1074/Jbc.M507464200 |
0.376 |
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| 2005 |
Durgam GG, Virag T, Walker MD, Tsukahara R, Yasuda S, Liliom K, van Meeteren LA, Moolenaar WH, Wilke N, Siess W, Tigyi G, Miller DD. Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. Journal of Medicinal Chemistry. 48: 4919-30. PMID 16033271 DOI: 10.1021/Jm049609R |
0.805 |
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| 2005 |
Gududuru V, Hurh E, Sullivan J, Dalton JT, Miller DD. SAR studies of 2-arylthiazolidine-4-carboxylic acid amides: a novel class of cytotoxic agents for prostate cancer. Bioorganic & Medicinal Chemistry Letters. 15: 4010-3. PMID 16005217 DOI: 10.1016/J.Bmcl.2005.06.032 |
0.37 |
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| 2005 |
Kim J, Wu D, Hwang DJ, Miller DD, Dalton JT. The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgen receptor modulators. The Journal of Pharmacology and Experimental Therapeutics. 315: 230-9. PMID 15987833 DOI: 10.1124/Jpet.105.088344 |
0.366 |
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| 2005 |
Mustafa SM, Bavadekar SA, Ma G, Moore BM, Feller DR, Miller DD. Synthesis and biological studies of yohimbine derivatives on human alpha2C-adrenergic receptors. Bioorganic & Medicinal Chemistry Letters. 15: 2758-60. PMID 15911252 DOI: 10.1016/J.Bmcl.2005.03.116 |
0.389 |
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| 2005 |
Bohl CE, Gao W, Miller DD, Bell CE, Dalton JT. Structural basis for antagonism and resistance of bicalutamide in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 102: 6201-6. PMID 15833816 DOI: 10.1073/Pnas.0500381102 |
0.329 |
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| 2005 |
Gududuru V, Hurh E, Dalton JT, Miller DD. Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer. Journal of Medicinal Chemistry. 48: 2584-8. PMID 15801848 DOI: 10.1021/Jm049208B |
0.4 |
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| 2005 |
Mohler ML, Nair VA, Hwang DJ, Rakov IM, Patil R, Miller DD. Nonsteroidal tissue selective androgen receptor modulators: A promising class of clinical candidates Expert Opinion On Therapeutic Patents. 15: 1565-1585. DOI: 10.1517/13543776.15.11.1565 |
0.336 |
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| 2005 |
Nair VA, Mustafa SM, Mohler ML, Yang J, Kirkovsky LI, Dalton JT, Miller DD. Synthesis of irreversibly binding bicalutamide analogs for imaging studies Tetrahedron Letters. 46: 4821-4823. DOI: 10.1016/J.Tetlet.2005.04.143 |
0.346 |
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| 2004 |
Gududuru V, Hurh E, Dalton JT, Miller DD. Synthesis and antiproliferative activity of 2-aryl-4-oxo-thiazolidin-3-yl-amides for prostate cancer. Bioorganic & Medicinal Chemistry Letters. 14: 5289-93. PMID 15454213 DOI: 10.1016/J.Bmcl.2004.08.029 |
0.353 |
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| 2004 |
Chen J, Hwang DJ, Bohl CE, Miller DD, Dalton JT. A selective androgen receptor modulator for hormonal male contraception. The Journal of Pharmacology and Experimental Therapeutics. 312: 546-53. PMID 15347734 DOI: 10.1124/Jpet.104.075424 |
0.348 |
|
| 2004 |
Gududuru V, Hurh E, Durgam GG, Hong SS, Sardar VM, Xu H, Dalton JT, Miller DD. Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer. Bioorganic & Medicinal Chemistry Letters. 14: 4919-23. PMID 15341952 DOI: 10.1016/J.Bmcl.2004.07.026 |
0.753 |
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| 2004 |
Gao W, Kearbey JD, Nair VA, Chung K, Parlow AF, Miller DD, Dalton JT. Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: New approach for benign prostate hyperplasia Endocrinology. 145: 5420-5428. PMID 15308613 DOI: 10.1210/En.2004-0627 |
0.336 |
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| 2004 |
Bohl CE, Chang C, Mohler ML, Chen J, Miller DD, Swaan PW, Dalton JT. A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor. Journal of Medicinal Chemistry. 47: 3765-76. PMID 15239655 DOI: 10.1021/Jm0499007 |
0.374 |
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| 2004 |
Marhefka CA, Gao W, Chung K, Kim J, He Y, Yin D, Bohl C, Dalton JT, Miller DD. Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators. Journal of Medicinal Chemistry. 47: 993-8. PMID 14761201 DOI: 10.1021/Jm030336U |
0.412 |
|
| 2004 |
Wu Z, Gao W, Phelps MA, Wu D, Miller DD, Dalton JT. Favorable effects of weak acids on negative-ion electrospray ionization mass spectrometry. Analytical Chemistry. 76: 839-47. PMID 14750883 DOI: 10.1021/Ac0351670 |
0.324 |
|
| 2004 |
Lalchandani SG, Zhang X, Hong SS, Liggett SB, Li W, Moore BM, Miller DD, Feller DR. Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors. Biochemical Pharmacology. 67: 87-96. PMID 14667931 DOI: 10.1016/J.Bcp.2003.08.043 |
0.322 |
|
| 2004 |
Nair VA, Mustafa SM, Mohler ML, Fisher SJ, Dalton JT, Miller DD. Synthesis of novel iodo derived bicalutamide analogs Tetrahedron Letters. 45: 9475-9477. DOI: 10.1016/J.Tetlet.2004.10.130 |
0.335 |
|
| 2003 |
Virag T, Elrod DB, Liliom K, Sardar VM, Parrill AL, Yokoyama K, Durgam G, Deng W, Miller DD, Tigyi G. Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors. Molecular Pharmacology. 63: 1032-42. PMID 12695531 DOI: 10.1124/Mol.63.5.1032 |
0.78 |
|
| 2003 |
Yin D, Gao W, Kearbey JD, Xu H, Chung K, He Y, Marhefka CA, Veverka KA, Miller DD, Dalton JT. Pharmacodynamics of selective androgen receptor modulators. The Journal of Pharmacology and Experimental Therapeutics. 304: 1334-40. PMID 12604714 DOI: 10.1124/Jpet.102.040840 |
0.4 |
|
| 2003 |
Yin D, Xu H, He Y, Kirkovsky LI, Miller DD, Dalton JT. Pharmacology, pharmacokinetics, and metabolism of acetothiolutamide, a novel nonsteroidal agonist for the androgen receptor. The Journal of Pharmacology and Experimental Therapeutics. 304: 1323-33. PMID 12604713 DOI: 10.1124/Jpet.102.040832 |
0.353 |
|
| 2003 |
Yin D, He Y, Perera MA, Hong SS, Marhefka C, Stourman N, Kirkovsky L, Miller DD, Dalton JT. Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor. Molecular Pharmacology. 63: 211-23. PMID 12488554 DOI: 10.1124/Mol.63.1.211 |
0.387 |
|
| 2002 |
Lalchandani SG, Lei L, Zheng W, Suni MM, Moore BM, Liggett SB, Miller DD, Feller DR. Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype. The Journal of Pharmacology and Experimental Therapeutics. 303: 979-84. PMID 12438517 DOI: 10.1124/Jpet.102.039057 |
0.321 |
|
| 2002 |
He Y, Yin D, Perera M, Kirkovsky L, Stourman N, Li W, Dalton JT, Miller DD. Novel nonsteroidal ligands with high binding affinity and potent functional activity for the androgen receptor. European Journal of Medicinal Chemistry. 37: 619-34. PMID 12161060 DOI: 10.1016/S0223-5234(02)01335-1 |
0.37 |
|
| 2001 |
Marhefka CA, Moore BM, Bishop TC, Kirkovsky L, Mukherjee A, Dalton JT, Miller DD. Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands Journal of Medicinal Chemistry. 44: 1729-1740. PMID 11356108 DOI: 10.1021/Jm0005353 |
0.345 |
|
| 2001 |
Liliom K, Sun G, Bünemann M, Virág T, Nusser N, Baker DL, Wang DA, Fabian MJ, Brandts B, Bender K, Eickel A, Malik KU, Miller DD, Desiderio DM, Tigyi G, et al. Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors. The Biochemical Journal. 355: 189-97. PMID 11256963 DOI: 10.1042/0264-6021:3550189 |
0.306 |
|
| 2000 |
Donkor IO, Zheng X, Han J, Miller DD. Asymmetric synthesis of 2,3-methanoleucine stereoisomers from common intermediates. Chirality. 12: 551-7. PMID 10861954 DOI: 10.1002/1520-636X(2000)12:7<551::Aid-Chir1>3.0.Co;2-C |
0.328 |
|
| 2000 |
Tigyi G, Fischer DJ, Baker D, Wang DA, Yue J, Nusser N, Virag T, Zsiros V, Liliom K, Miller D, Parrill A. Pharmacological characterization of phospholipid growth-factor receptors. Annals of the New York Academy of Sciences. 905: 34-53. PMID 10818440 DOI: 10.1111/J.1749-6632.2000.Tb06536.X |
0.38 |
|
| 2000 |
Kirkovsky L, Mukherjee A, Yin D, Dalton JT, Miller DD. Chiral nonsteroidal affinity ligands for the androgen receptor. 1. Bicalutamide analogues bearing electrophilic groups in the B aromatic ring. Journal of Medicinal Chemistry. 43: 581-90. PMID 10691684 DOI: 10.1021/Jm990027X |
0.348 |
|
| 2000 |
Mehta RC, Salazar-Bookaman MM, Fertel RH, De Los Angeles J, Nikulin VI, Fraundorfer PF, Miller DD, Feller DR. Biochemical and functional characterization of 1-benzyl substituted trimetoquinol affinity analogs on rat and human beta-adrenoceptors. Biochemical Pharmacology. 59: 517-29. PMID 10660118 DOI: 10.1016/S0006-2952(99)00376-7 |
0.325 |
|
| 1999 |
Tigyi G, Fisher DJ, Lilion K, Guo Z, Virag T, Sun G, Miller DD, Murakami-Murofushi K, Kobayashi S, Erickson JR. Determinants of receptor subtype specificity in the LPA-like lipid mediator family. Advances in Experimental Medicine and Biology. 469: 245-51. PMID 10667337 DOI: 10.1007/978-1-4615-4793-8_36 |
0.375 |
|
| 1999 |
Zheng W, Nikulin VI, Konkar AA, Vansal SS, Shams G, Feller DR, Miller DD. 2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridines: novel selective beta3-adrenoceptor agonists. Journal of Medicinal Chemistry. 42: 2287-94. PMID 10377236 DOI: 10.1021/Jm990012Z |
0.306 |
|
| 1998 |
Fischer DJ, Liliom K, Guo Z, Nusser N, Virág T, Murakami-Murofushi K, Kobayashi S, Erickson JR, Sun G, Miller DD, Tigyi G. Naturally occurring analogs of lysophosphatidic acid elicit different cellular responses through selective activation of multiple receptor subtypes. Molecular Pharmacology. 54: 979-88. PMID 9855625 DOI: 10.1124/Mol.54.6.979 |
0.375 |
|
| 1998 |
Liliom K, Fischer DJ, Virág T, Sun G, Miller DD, Tseng JL, Desiderio DM, Seidel MC, Erickson JR, Tigyi G. Identification of a novel growth factor-like lipid, 1-O-cis-alk-1'-enyl-2-lyso-sn-glycero-3-phosphate (alkenyl-GP) that is present in commercial sphingolipid preparations. The Journal of Biological Chemistry. 273: 13461-8. PMID 9593679 DOI: 10.1074/Jbc.273.22.13461 |
0.331 |
|
| 1998 |
Lei L, Vaghy PL, Slavica M, De Los Angeles J, Smith B, Miller DD, Feller DR. Activation of L-type calcium channel by tolazoline derivatives: role of isothiocyanate moiety. Journal of Cardiovascular Pharmacology. 31: 721-33. PMID 9593072 DOI: 10.1097/00005344-199805000-00011 |
0.31 |
|
| 1998 |
Sun G, Slavica M, Uretsky NJ, Wallace LJ, Shams G, Weinstein DM, Miller JC, Miller DD. Design and synthesis of enantiomers of 3,5-dinitro-o-tyrosine: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptor antagonists. Journal of Medicinal Chemistry. 41: 1034-41. PMID 9544203 DOI: 10.1021/Jm970276Q |
0.377 |
|
| 1998 |
Dalton JT, Mukherjee A, Zhu Z, Kirkovsky L, Miller DD. Discovery of nonsteroidal androgens. Biochemical and Biophysical Research Communications. 244: 1-4. PMID 9514878 DOI: 10.1006/Bbrc.1998.8209 |
0.361 |
|
| 1997 |
Hill RA, Wallace LJ, Miller DD, Weinstein DM, Shams G, Tai H, Layer RT, Willins D, Uretsky NJ, Danthi SN. Structure--activity studies for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid receptors: acidic hydroxyphenylalanines. Journal of Medicinal Chemistry. 40: 3182-91. PMID 9379437 DOI: 10.1021/Jm950028Z |
0.391 |
|
| 1997 |
Zhang X, De Los Angeles JE, He MY, Dalton JT, Shams G, Lei L, Patil PN, Feller DR, Miller DD, Hsu FL. Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potential binding interactions with alpha 2-adrenoceptors involving a "methyl pocket". Journal of Medicinal Chemistry. 40: 3014-24. PMID 9301663 DOI: 10.1021/Jm960642Q |
0.306 |
|
| 1997 |
Shams G, Romstedt KJ, Lust LA, Clark MT, Miller DD, Feller DR. Beta-adrenergic receptor and platelet inhibitory activities of a new series of trimetoquinol and related benzazepine analogs. General Pharmacology. 28: 323-30. PMID 9013212 DOI: 10.1016/S0306-3623(96)00223-6 |
0.385 |
|
| 1997 |
Mukherjee A, Kirkovsky L, Yao XT, Yates RC, Miller DD, Dalton JT. Enantioselective binding of Casodex to the androgen receptor. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 26: 117-22. PMID 8867996 DOI: 10.3109/00498259609046693 |
0.348 |
|
| 1996 |
Bünemann M, Liliom K, Brandts BK, Pott L, Tseng JL, Desiderio DM, Sun G, Miller D, Tigyi G. A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. The Embo Journal. 15: 5527-34. PMID 8896446 DOI: 10.1002/J.1460-2075.1996.Tb00937.X |
0.387 |
|
| 1996 |
Sun G, Uretsky NJ, Wallace LJ, Shams G, Weinstein DM, Miller DD. Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor agonists and antagonists. Journal of Medicinal Chemistry. 39: 4430-8. PMID 8893837 DOI: 10.1021/jm950632 |
0.357 |
|
| 1996 |
Ishikawa H, Miller DD, Patil PN. Irreversible agonist and antagonist properties of isothiocyanatobenzyl imidazoline in albino rabbit iris muscles Naunyn-Schmiedeberg's Archives of Pharmacology. 354: 362-368. PMID 8878068 DOI: 10.1007/Bf00171069 |
0.303 |
|
| 1996 |
Ishikawa H, Miller DD, Patil PN. Actions of imidazolines on bovine ciliary artery Journal of Ocular Pharmacology and Therapeutics. 12: 313-322. PMID 8875337 DOI: 10.1089/Jop.1996.12.313 |
0.301 |
|
| 1996 |
De Los Angeles JE, Nikulin VI, Shams G, Konkar AA, Mehta R, Feller DR, Miller DD. Iodinated analogs of trimetoquinol as highly potent and selective beta 2-adrenoceptor ligands. Journal of Medicinal Chemistry. 39: 3701-11. PMID 8809159 DOI: 10.1021/Jm960208O |
0.311 |
|
| 1996 |
Zhang X, Yao XT, Dalton JT, Shams G, Lei L, Patil PN, Feller DR, Hsu FL, George C, Miller DD. Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine. Journal of Medicinal Chemistry. 39: 3001-13. PMID 8709134 DOI: 10.1021/Jm9506074 |
0.304 |
|
| 1994 |
Slavica M, Lei L, Patil PN, Kerezy A, Feller DR, Miller DD. Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta. Journal of Medicinal Chemistry. 37: 1874-81. PMID 8021927 DOI: 10.1021/Jm00038A017 |
0.328 |
|
| 1994 |
Hong SS, Romstedt KJ, Feller DR, Hsu FL, Cupps TL, Lyon RA, Miller DD. A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors. Journal of Medicinal Chemistry. 37: 2328-33. PMID 7914537 DOI: 10.1021/Jm00041A011 |
0.313 |
|
| 1994 |
Farooqui T, Brooks K, Harrold MW, Miller DD, Wallace LJ, Uretsky NJ. Interaction of permanently charged metoclopramide analogs with D-2 dopamine receptors. General Pharmacology. 25: 1577-84. PMID 7721031 DOI: 10.1016/0306-3623(94)90357-3 |
0.306 |
|
| 1993 |
Farooqui T, Markovich K, Wallace L, Miller D, Uretsky N. Interaction of AZA analogs of chlorpromazine with the dopamine D2 receptor General Pharmacology. 24: 147-151. PMID 8482489 DOI: 10.1016/0306-3623(93)90026-T |
0.32 |
|
| 1993 |
Abdel-Ghany YS, Ihnat MA, Miller DD, Kunin CM, Tong HH. Structure-activity relationship of glycine betaine analogs on osmotolerance of enteric bacteria. Journal of Medicinal Chemistry. 36: 784-9. PMID 8459406 DOI: 10.1021/Jm00058A017 |
0.31 |
|
| 1993 |
Kunin CM, Tong HH, Miller DD, Abdel-Ghany Y, Poggi MC, LeRudulier D. Effect of novel compound, 1-methyl-1-piperidino methane sulfonate (MPMS), on the osmoprotectant activity of glycine betaine, choline and L-proline in Escherichia coli. Archives of Microbiology. 160: 81-6. PMID 8397499 DOI: 10.1007/Bf00288707 |
0.305 |
|
| 1993 |
Romstedt KJ, Shin Y, Shams G, Doyle K, Tantishaiyakul V, Clark MT, Adejare A, Hamada A, Miller DD, Feller DR. Halogen-substituted trimetoquinol analogs as thromboxane A2 receptor antagonists in platelets and aorta. Biochemical Pharmacology. 46: 2051-9. PMID 8267653 DOI: 10.1016/0006-2952(93)90647-F |
0.702 |
|
| 1993 |
Harrold MW, Sriburi A, Matsumoto K, Miller DD, Farooqui T, Uretsky N. The interaction of ammonium, sulfonium, and sulfide analogues of metoclopramide with the dopamine D2 receptor. Journal of Medicinal Chemistry. 36: 3166-70. PMID 8230103 DOI: 10.1021/Jm00073A017 |
0.349 |
|
| 1993 |
Markovich KM, Farooqui T, Wallace LJ, Uretsky NJ, Miller DD. Enhancement of binding of quaternary ammonium derivatives of chlorpromaxine to dopamine D-2 receptors by the addition of a H-bonding group Bioorganic and Medicinal Chemistry Letters. 3: 1241-1244. DOI: 10.1016/S0960-894X(00)80323-6 |
0.319 |
|
| 1992 |
Smar MW, Ares JJ, Nakayama T, Itabe H, Kador PF, Miller DD. Selective irreversible inhibitors of aldose reductase. Journal of Medicinal Chemistry. 35: 1117-20. PMID 1552504 DOI: 10.1021/Jm00084A017 |
0.323 |
|
| 1992 |
Hong SS, Romstedt KJ, Feller DR, Hsu FL, George C, Cupps TL, Lyon RA, Miller DD. Resolution and adrenergic activities of the optical isomers of 4-[1-(1-naphthyl)ethyl]-1H-imidazole. Chirality. 4: 432-8. PMID 1361151 DOI: 10.1002/Chir.530040706 |
0.34 |
|
| 1992 |
Amemiya Y, Hong SS, Venkataraman BV, Patil PN, Shams G, Romstedt K, Feller DR, Hsu FL, Miller DD. Synthesis and alpha-adrenergic activities of 2- and 4-substituted imidazoline and imidazole analogues. Journal of Medicinal Chemistry. 35: 750-5. PMID 1347319 DOI: 10.1021/Jm00082A017 |
0.314 |
|
| 1992 |
Markovich KM, Tantishaiyakul V, Hamada A, Miller DD, Romstedt KJ, Shams G, Shin Y, Fraundorfer PF, Doyle K, Feller DR. Synthesis of halogenated trimetoquinol derivatives and evaluation of their beta-agonist and thromboxane A2 (TXA2) antagonist activities. Journal of Medicinal Chemistry. 35: 466-79. PMID 1346651 DOI: 10.1021/Jm00081A007 |
0.339 |
|
| 1992 |
Esbenshade TA, Hamada A, Miller DD, Feller DR. Effects of the stereochemical orientation of phenethylamines and imidazolines on alpha-adrenergic receptor-mediated DNA synthesis in primary cultured rat hepatocytes. Chirality. 4: 279-85. PMID 1323987 DOI: 10.1002/Chir.530040504 |
0.356 |
|
| 1991 |
Shin Y, Romstedt KJ, Doyle K, Harrold MW, Gerhardt MA, Miller DD, Patil PN, Feller DR. Pharmacologic antagonism of thromboxane A2 receptors by trimetoquinol analogs in vitro and in vivo Chirality. 3: 112-117. PMID 1830752 DOI: 10.1002/Chir.530030206 |
0.388 |
|
| 1991 |
Shams G, Fedyna J, Romstedt KJ, Adejare A, Miller DD, Roche VF, Feller DR. Pharmacological properties of novel bicyclic isoquinoline analogs in isolated guinea pig atria, trachea and in human platelets: Relationship to trimetoquinol General Pharmacology. 22: 1155-1163. PMID 1687397 DOI: 10.1016/0306-3623(91)90595-W |
0.693 |
|
| 1991 |
Shams G, Venkataraman BV, Hamada A, Miller DD, Patil PN, Feller DR. Diversity of the pharmacological actions of some tolazoline analogues in human platelets and rat aorta. European Journal of Pharmacology. 199: 315-23. PMID 1655482 DOI: 10.1016/0014-2999(91)90495-C |
0.348 |
|
| 1990 |
Ahn Ch, Shams G, Schotzinger RL, Miller DD, Feller DR. Stereostructure Activity Relationships of Catecholamines on Human Platelet Function Proceedings of the Society For Experimental Biology and Medicine. 194: 149-156. PMID 2190233 DOI: 10.3181/00379727-194-43071 |
0.311 |
|
| 1990 |
Miller DD, Hamada A, Clark MT, Adejare A, Patil PN, Shams G, Romstedt KJ, Kim SU, Intrasuksri U, McKenzie JL. Synthesis and alpha 2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogues in human platelets. Journal of Medicinal Chemistry. 33: 1138-44. PMID 2157007 DOI: 10.1021/jm00166a009 |
0.643 |
|
| 1990 |
Shams G, Wallace LJ, Miller DD, Feller DR. Effects of thromboxane a2 on thoracic aorta of young and old rats: Use of selective thromboxane receptor antagonists Pharmacology. 40: 27-32. PMID 2139513 DOI: 10.1159/000138635 |
0.341 |
|
| 1990 |
Shams G, Romstedt KJ, Gerhardt MA, Harrold MW, Miller DD, Feller DR. Pharmacological evaluation of the β-adrenoceptor agonist and thromboxane receptor blocking properties of 1-benzyl substituted trimetoquinol analogues European Journal of Pharmacology. 184: 21-31. PMID 1976530 DOI: 10.1016/0014-2999(90)90663-Q |
0.34 |
|
| 1989 |
Rice PJ, Miller DD, Sokoloski TD, Patil PN. Pharmacologic implications of α-adrenoreceptor interactive parameters for epinephrine enantiomers in the rat vas deferens Chirality. 1: 14-19. PMID 2561990 DOI: 10.1002/Chir.530010106 |
0.318 |
|
| 1989 |
Nichols AJ, Hamada A, Adejare A, Miller DD, Patil PN, Ruffolo RR. Effect of aromatic fluorine substitution on the alpha and beta adrenoceptor-mediated effects of 3,4-dihydroxytolazoline in the pithed rat. The Journal of Pharmacology and Experimental Therapeutics. 248: 671-6. PMID 2537407 |
0.639 |
|
| 1989 |
Wallace RA, Wallace L, Harrold M, Miller D, Uretsky NJ. Interaction of permanently charged chlorpromazine and dopamine analogs with the striatal D-1 dopaminergic receptor Biochemical Pharmacology. 38: 2019-2025. PMID 2525907 DOI: 10.1016/0006-2952(89)90502-9 |
0.339 |
|
| 1989 |
Harrold MW, Wallace RA, Farooqui T, Wallace LJ, Uretsky N, Miller DD. Synthesis and D2 dopaminergic activity of pyrrolidinium, tetrahydrothiophenium, and tetrahydrothiophene analogues of sulpiride Journal of Medicinal Chemistry. 32: 874-880. PMID 2522993 DOI: 10.1021/Jm00124A024 |
0.352 |
|
| 1988 |
Harrold MW, Grajzl B, Shin Y, Romstedt KJ, Feller DR, Miller DD. Synthesis and thromboxane A2 antagonist activity of N-benzyltrimetoquinol analogues Journal of Medicinal Chemistry. 31: 1506-1512. PMID 3397988 DOI: 10.1021/Jm00403A006 |
0.392 |
|
| 1988 |
Chang-Ho A, Romstedt KJ, Wallace LJ, Miller DD, Feller DR. Characterization of the inhibition of U46619-mediated human platelet activation by the trimetoquinol isomers. Evidence for endoperoxide/thromboxane A2 receptor blockade Biochemical Pharmacology. 37: 3023-3033. PMID 3134894 DOI: 10.1016/0006-2952(88)90292-4 |
0.348 |
|
| 1988 |
Ahn CH, Wallace LJ, Miller DD, Feller DR. Use of [3h]trimetoquinol as a radioligand in human platelets: Interaction with putative endoperoxide/thromboxane A2 receptor sites Thrombosis Research. 50: 387-399. PMID 2969151 DOI: 10.1016/0049-3848(88)90268-X |
0.326 |
|
| 1988 |
Wallace RA, Farooqui T, Wallace L, Ares J, Yu An C, Miller D, Uretsky N. Interaction of permanently uncharged dopamine analogs with the D-2 dopaminergic receptor Biochemical Pharmacology. 37: 2077-2084. PMID 2967702 DOI: 10.1016/0006-2952(88)90559-X |
0.307 |
|
| 1988 |
Lamba-Kanwal VK, Hamada A, Adejare A, Clark MT, Miller DD, Patil PN. Activation of alpha-1 adrenoreceptors of rat aorta by analogs of imidazoline. The Journal of Pharmacology and Experimental Therapeutics. 245: 793-7. PMID 2838604 |
0.665 |
|
| 1987 |
Chambers ST, Kunin CM, Miller D, Hamada A. Dimethylthetin can substitute for glycine betaine as an osmoprotectant molecule for Escherichia coli. Journal of Bacteriology. 169: 4845-7. PMID 3308858 DOI: 10.1128/Jb.169.10.4845-4847.1987 |
0.319 |
|
| 1987 |
Harrold MW, Chang YA, Wallace RA, Farooqui T, Wallace LJ, Uretsky N, Miller DD. Charged analogues of chlorpromazine as dopamine antagonists Journal of Medicinal Chemistry. 30: 1631-1635. PMID 2887659 DOI: 10.1021/Jm00392A019 |
0.34 |
|
| 1987 |
Fedyna JS, Adejare A, Miller DD, Feller DR. Pharmacological evaluation of the β-adrenoceptor agonist and thromboxane antagonist properties of N-substituted trimetoquinol analogues European Journal of Pharmacology. 135: 161-171. PMID 2884118 DOI: 10.1016/0014-2999(87)90608-X |
0.668 |
|
| 1987 |
Clark MT, Adejare A, Shams G, Feller DR, Miller DD. 5-fluoro- and 8-fluorotrimetoquinol: selective beta 2-adrenoceptor agonists. Journal of Medicinal Chemistry. 30: 86-90. PMID 2879920 DOI: 10.1021/Jm00384A015 |
0.644 |
|
| 1986 |
Ares JJ, Kador PF, Miller DD. Synthesis and biological evaluation of irreversible inhibitors of aldose reductase. Journal of Medicinal Chemistry. 29: 2384-9. PMID 3097318 DOI: 10.1021/Jm00161A040 |
0.325 |
|
| 1986 |
Boldry R, Chang Y, Miller DD, Uretsky NJ. Behavioral effects of a dimethylsulfonium analog of dopamine after injection into the nucleus accumbens and the striatum. Pharmacology, Biochemistry and Behavior. 24: 223-228. PMID 3081914 DOI: 10.1016/0091-3057(86)90342-4 |
0.312 |
|
| 1986 |
Adejare A, Miller DD, Fedyna JS, Ahn CH, Feller DR. Syntheses and β-adrenergic agonist and antiaggregatory properties of N-substituted trimetoquinol analogues Journal of Medicinal Chemistry. 29: 1603-1609. PMID 2875182 DOI: 10.1021/Jm00159A008 |
0.683 |
|
| 1986 |
CLARK MT, CHANG J, NAVRAN SS, HUZOOR-AKBAR H, MUKHOPADHYAY A, AMIN H, FELLER DR, MILLER DD. ChemInform Abstract: Synthesis and Investigation of the β-Adrenoceptor Agonist and Platelet Antiaggregatory Properties of 1,7,8-Trisubstituted 2,3,4,5-Tetrahydro-1H-2-benzazepine Analogues of Trimetoquinol. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198623244 |
0.308 |
|
| 1985 |
Huzoor-Akbar, Mukhopadhyay A, Anderson KS, Navran SS, Romstedt K, Miller DD, Feller DR. Antagonism of prostaglandin-mediated responses in platelets and vascular smooth muscle by 13-azaprostanoic acid analogs. Evidence for selective blockade of thromboxane A2 responses Biochemical Pharmacology. 34: 641-647. PMID 3156599 DOI: 10.1016/0006-2952(85)90258-8 |
0.383 |
|
| 1985 |
Hamada A, Yaden EL, Horng JS, Ruffolo RR, Patil PN, Miller DD. N-substituted imidazolines and ethylenediamines and their action on alpha- and beta-adrenergic receptors. Journal of Medicinal Chemistry. 28: 1269-73. PMID 2993616 DOI: 10.1021/Jm00147A026 |
0.345 |
|
| 1984 |
Nichols DE, Jadhav KP, Oberlender RA, Zabik JE, Bossart JF, Hamada A, Miller DD. Synthesis and evaluation of substituted 2-phenylcyclobutylamines as analogues of hallucinogenic phenethylamines: lack of LSD-like biological activity. Journal of Medicinal Chemistry. 27: 1108-11. PMID 6471065 DOI: 10.1002/Chin.198505188 |
0.302 |
|
| 1984 |
Navran SS, Romstedt K, Chang J, Miller DD, Feller DR, Huzoor-Akbar. Human platelet activation by bacterial phospholipase C is mediated by phosphatidylinositol hydrolysis but not generation of phosphatidic acid: Inhibition by a selective inhibitor of phospholipase C Thrombosis Research. 33: 499-510. PMID 6372157 DOI: 10.1016/0049-3848(84)90015-X |
0.332 |
|
| 1984 |
Hamada A, Chang YA, Uretsky N, Miller DD. Dopaminergic agonists: comparative actions of amine and sulfonium analogues of dopamine. Journal of Medicinal Chemistry. 27: 675-80. PMID 6143827 DOI: 10.1021/Jm00371A021 |
0.334 |
|
| 1984 |
Adejare A, Miller DD. Synthesis of fluorinated biphenyls via aryne reaction Tetrahedron Letters. 25: 5597-5598. DOI: 10.1016/S0040-4039(01)91388-7 |
0.634 |
|
| 1982 |
Huzoor-Akbar, Navran SS, Chang J, Miller DD, Feller DR. Investigation of the effects of phospholipase C on human platelets: evidence that aggregation induced by phospholipase C is independent of prostaglandin generation, released ADP and is modulated by cyclic AMP Thrombosis Research. 27: 405-417. PMID 6293114 DOI: 10.1016/0049-3848(82)90058-5 |
0.305 |
|
| 1981 |
Mayo JR, Navran SS, Huzoor-Akbar, Miller DD, Feller DR. Stereo-dependent inhibition of human platelet function by the optical isomers of trimetoquinol Biochemical Pharmacology. 30: 2237-2241. PMID 7188564 DOI: 10.1016/0006-2952(81)90093-9 |
0.337 |
|
| 1981 |
Sober DJ, Chang J, Fowble JW, Mukhopadhyay A, Feller DR, Miller DD, Fairchild EH. Selective and potent beta 2-adrenoceptor agents within the tetrahydroisoquinoline class: effect of methyl substitution at the benzylic carbon of the 1-(3,4,5-trimethoxybenzyl) group of trimetoquinol. Journal of Medicinal Chemistry. 24: 970-4. PMID 6120236 DOI: 10.1021/Jm00140A011 |
0.314 |
|
| 1981 |
Fuder H, Nelson WL, Miller DD, Patil PN. Alpha adrenoreceptors of rabbit aorta and stomach fundus Journal of Pharmacology and Experimental Therapeutics. 217: 1-9. PMID 6110772 |
0.518 |
|
| 1980 |
Miller DD, Bossart JF, Mayo JR, Feller DR. Synthesis, β-adrenergic activity, and platelet antiaggregatory activity of a positional isomer of trimetoquinol: 1-(2′,4′,5′-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline Journal of Medicinal Chemistry. 23: 331-333. PMID 6102607 DOI: 10.1021/Jm00177A027 |
0.347 |
|
| 1980 |
MILLER DD, BOSSART JF, MAYO JR, FELLER DR. ChemInform Abstract: SYNTHESIS, β-ADRENERGIC ACTIVITY, AND PLATELET ANTIAGGREGATORY ACTIVITY OF A POSITIONAL ISOMER OF TRIMETOQUINOL: 1-(2′,4′,5′-TRIMETHOXYBENZYL)-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE Chemischer Informationsdienst. 11. DOI: 10.1002/Chin.198034213 |
0.31 |
|
| 1979 |
Piascik MT, Piascik MF, Miller DD, Feller DR. 1-substituted tetrahydroisoquinoline analogs: Beta adrenoceptor blocking agents in the isolated perfused rabbit heart Life Sciences. 24: 2433-2439. PMID 39210 DOI: 10.1016/0024-3205(79)90452-1 |
0.323 |
|
| 1978 |
Osei-Gyimah P, Piascik MT, Fowble JW, Feller DR, Miller DD. Synthesis and β-adrenoceptor activity of the erythro and threo isomers of substituted α-hydroxytrimetoquinol Journal of Medicinal Chemistry. 21: 1173-1178. PMID 31479 DOI: 10.1021/Jm00209A019 |
0.323 |
|
| 1978 |
Piascik MT, Osei-Gyimah P, Miller DD, Feller DR. Stereoselective interaction of tetrahydroisoquinolines in β-adrenoceptor systems European Journal of Pharmacology. 48: 393-401. PMID 25778 DOI: 10.1016/0014-2999(78)90166-8 |
0.307 |
|
| 1978 |
MILLER DD, OSEI-GYIMAH P, RAMAN RV, FELLER DR. ChemInform Abstract: SYNTHESIS OF 1-SUBSTITUTED ANALOGS OF TRIMETOQUINOL POSSESSING DIFFERENTIAL AND SELECTIVE β-ADRENERGIC PROPERTIES Chemischer Informationsdienst. 9. DOI: 10.1002/Chin.197816225 |
0.301 |
|
| 1977 |
Miller DD, Osei-Gyimah P, Raman RV, Feller DR. Synthesis of 1-substituted analogues of trimetoquinol possessing differential and selective β-adrenergic properties Journal of Medicinal Chemistry. 20: 1502-1504. PMID 21293 DOI: 10.1021/Jm00221A029 |
0.32 |
|
| 1977 |
Kador PF, Venkatraman R, Feller DR, Miller DD. Synthesis and biological evaluation of a tetrahydroisoquinoline derivative possessing selective beta2-adrenergic agonist activity. Journal of Medicinal Chemistry. 20: 891-4. PMID 17750 DOI: 10.1021/Jm00217A004 |
0.342 |
|
| 1977 |
KADOR PF, VENKATRAMAN R, FELLER DR, MILLER DD. ChemInform Abstract: SYNTHESIS AND BIOLOGICAL EVALUATION OF A TETRAHYDROISOQUINOLINE DERIVATIVE POSSESSING SELECTIVE β2-ADRENERGIC AGONIST ACTIVITY Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/Chin.197743238 |
0.352 |
|
| 1976 |
Salman KN, Chai HS, Miller DD, Patil PN. Influence of group selective reagents in tissues containing alpha- and beta-adrenoceptors. European Journal of Pharmacology. 36: 41-8. PMID 1261602 DOI: 10.1016/0014-2999(76)90254-5 |
0.319 |
|
| 1976 |
Ruffolo RR, Fowble JW, Miller DD, Patil PN. Binding of [3H]dihydroazapetine to alpha-adrenoreceptor-related proteins from rat vas deferens. Proceedings of the National Academy of Sciences of the United States of America. 73: 2730-4. PMID 8779 DOI: 10.1073/Pnas.73.8.2730 |
0.323 |
|
| 1975 |
Miller DD, Osei-Gyimah P, Bardin J, Feller DR. Synthesis and biological evaluation of fragmented derivatives of tetrahydroisoquinolines. 2. Trimetoquinol studies Journal of Medicinal Chemistry. 18: 454-457. PMID 239233 DOI: 10.1021/Jm00239A002 |
0.353 |
|
| 1974 |
Lee OS, Mears JA, Miller DD, Feller DR. Evaluation of the optical isomers of tetrahydroisoquinolines in rat adipose tissue and guinea pig aorta. European Journal of Pharmacology. 28: 225-9. PMID 4430326 DOI: 10.1016/0014-2999(74)90137-X |
0.305 |
|
| 1971 |
Shonk RF, Miller DD, Feller DR. Influence of substituted tetrahydroisoquinolines and catecholamines on lipolysis, in vitro-II. Stereoselectivity Biochemical Pharmacology. 20: 3403-3412. PMID 5132887 DOI: 10.1016/0006-2952(71)90445-X |
0.345 |
|
| 1970 |
Nelson WL, Miller DD. Tricyclic norephedrine analogs. The isomeric 9-hydroxy-10-amino-1,2,3,4,4a,9,10,10a-(trans-4a,10a)-octahydrophenanthrenes Journal of Medicinal Chemistry. 13: 807-814. PMID 4394055 DOI: 10.1021/Jm00299A005 |
0.463 |
|
| 1970 |
Nelson WL, Miller DD, Shefter E. Acetyl nitrate addition to cyclic olefins. The isomeric 9-acetoxy-10-nitro-1,2,3,4,4a,9,10,10a-(trans-4a,10a)-octahydrophenanthrenes Journal of Organic Chemistry. 35: 3433-3436. DOI: 10.1021/Jo00835A054 |
0.432 |
|
| 1970 |
Nelson WL, Miller DD. Oxazoline formation from N-acylaziridines. Isolation of an intermediate in an octahydrophenanthrene system Journal of Organic Chemistry. 35: 1185-1187. DOI: 10.1021/Jo00829A076 |
0.423 |
|
| 1969 |
Nelson WL, Miller DD, Wilson RS. Cyclic lactams. The hexahydrodibenzazepinones from l,2,3,4,4a,9,10,10a-(trans-4a,10a)-octahydro-9-oxophenanthrene Journal of Heterocyclic Chemistry. 6: 131-133. DOI: 10.1002/Jhet.5570060127 |
0.418 |
|
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