Michele D. Hastings, Ph.D.

Affiliations: 
2004 University of Washington, Seattle, Seattle, WA 
Area:
Genetics, Pathology, Pharmacology
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"Michele Hastings"

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Carol H. Sibley grad student 2004 University of Washington
 (Analysis of dihydrofolate reductase variations in relation to antifolate resistance in Plasmodium vivax.)
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Publications

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Hastings MD, Maguire JD, Bangs MJ, et al. (2005) Novel Plasmodium vivax dhfr alleles from the Indonesian Archipelago and Papua New Guinea: association with pyrimethamine resistance determined by a Saccharomyces cerevisiae expression system. Antimicrobial Agents and Chemotherapy. 49: 733-40
Hastings MD, Porter KM, Maguire JD, et al. (2004) Dihydrofolate reductase mutations in Plasmodium vivax from Indonesia and therapeutic response to sulfadoxine plus pyrimethamine. The Journal of Infectious Diseases. 189: 744-50
Hastings MD, Bates SJ, Blackstone EA, et al. (2002) Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene. 96: 674-6
Hastings MD, Sibley CH. (2002) Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax. Proceedings of the National Academy of Sciences of the United States of America. 99: 13137-41
Brophy VH, Hastings MD, Clendenning JB, et al. (2001) Polymorphisms in the human paraoxonase (PON1) promoter. Pharmacogenetics. 11: 77-84
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