Shawn M. Wnek, Ph.D.
Affiliations: | 2011 | Pharmacology & Toxicology | University of Arizona, Tucson, AZ |
Area:
Toxicology, Cell Biology, Genetics, OncologyGoogle:
"Shawn Wnek"Parents
Sign in to add mentor| A Jay Gandolfi | grad student | 2011 | University of Arizona | |
| (Mechanisms of malignant transformation of human urothelial cells by monomethylarsonous acid.) | ||||
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| Medeiros M, Zheng X, Novak P, et al. (2012) Global gene expression changes in human urothelial cells exposed to low-level monomethylarsonous acid. Toxicology. 291: 102-12 |
| Wnek SM, Kuhlman CL, Camarillo JM, et al. (2011) Interdependent genotoxic mechanisms of monomethylarsonous acid: role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells. Toxicology and Applied Pharmacology. 257: 1-13 |
| Wnek SM, Jensen TJ, Severson PL, et al. (2010) Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure. Toxicological Sciences : An Official Journal of the Society of Toxicology. 116: 44-57 |
| Escudero-Lourdes C, Medeiros MK, Cárdenas-González MC, et al. (2010) Low level exposure to monomethyl arsonous acid-induced the over-production of inflammation-related cytokines and the activation of cell signals associated with tumor progression in a urothelial cell model. Toxicology and Applied Pharmacology. 244: 162-73 |
| Jensen TJ, Novak P, Wnek SM, et al. (2009) Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells. Toxicology and Applied Pharmacology. 241: 221-9 |
| Wnek SM, Medeiros MK, Eblin KE, et al. (2009) Persistence of DNA damage following exposure of human bladder cells to chronic monomethylarsonous acid. Toxicology and Applied Pharmacology. 241: 202-9 |
| Jensen TJ, Wozniak RJ, Eblin KE, et al. (2009) Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation. Toxicology and Applied Pharmacology. 235: 39-46 |
| Eblin KE, Jensen TJ, Wnek SM, et al. (2009) Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling. Toxicology. 255: 107-14 |