David A. McDonald
Affiliations: | Duke University, Durham, NC |
Area:
education, graduate student education, career outcomes, career developmentGoogle:
"David McDonald"Parents
Sign in to add mentor| Peggy Borum | research assistant | 2004-2008 | UF Gainesville | |
| Douglas Marchuk | grad student | 2008-2013 | Duke | |
| (Cerebral Cavernous Malformations: From Two-Hit Mechanism to Developing a Targeted Therapy.) | ||||
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Publications
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| Shenkar R, Shi C, Austin C, et al. (2016) RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations. Stroke |
| Shenkar R, Shi C, Rebeiz T, et al. (2015) Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 17: 188-96 |
| McDonald DA, Shi C, Shenkar R, et al. (2014) Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis. Human Molecular Genetics. 23: 4357-70 |
| McDonald DA, Shi C, Shenkar R, et al. (2012) Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke; a Journal of Cerebral Circulation. 43: 571-4 |
| Dickinson RE, Griffin H, Bigley V, et al. (2011) Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood. 118: 2656-8 |
| Hambleton S, Salem S, Bustamante J, et al. (2011) IRF8 mutations and human dendritic-cell immunodeficiency. The New England Journal of Medicine. 365: 127-38 |
| McDonald DA, Shenkar R, Shi C, et al. (2011) A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Human Molecular Genetics. 20: 211-22 |
| Jones LL, McDonald DA, Borum PR. (2010) Acylcarnitines: role in brain. Progress in Lipid Research. 49: 61-75 |