Brian W. Freie, Ph.D.
Affiliations: | 2003 | Indiana University, Bloomington, Bloomington, IN, United States |
Area:
Oncology, Genetics, Cell BiologyGoogle:
"Brian Freie"Parents
Sign in to add mentor| Wade D. Clapp | grad student | 2003 | Indiana University Bloomington | |
| (Role of Fanconi anemia type C (FANCC) and its cooperation with tumor suppressor p53 in cell cycle checkpoint control, apoptosis, and tumorigenesis.) | ||||
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Publications
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| Freie B, Carroll PA, Varnum-Finney BJ, et al. (2024) A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies. Genes & Development |
| Freie B, Carroll PA, Varnum-Finney BJ, et al. (2023) A Germline Point Mutation in the MYC-FBW7 Phosphodegron Initiates Hematopoietic Malignancies. Biorxiv : the Preprint Server For Biology |
| Mathsyaraja H, Freie B, Cheng PF, et al. (2019) deletion destabilizes MYC protein and abrogates Eµ- lymphomagenesis. Genes & Development |
| Park H, Staehling-Hampton K, Appleby MW, et al. (2008) A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity. The Journal of Experimental Medicine. 205: 2899-913 |
| Li X, Le Beau MM, Ciccone S, et al. (2005) Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy. Blood. 105: 3465-71 |
| Freie BW, Ciccone SL, Li X, et al. (2004) A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint. The Journal of Biological Chemistry. 279: 50986-93 |
| Park SJ, Ciccone SL, Beck BD, et al. (2004) Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins. The Journal of Biological Chemistry. 279: 30053-9 |
| Li X, Yang Y, Yuan J, et al. (2004) Continuous in vivo infusion of interferon-gamma (IFN-γ) preferentially reduces myeloid progenitor numbers and enhances engraftment of syngeneic wild-type cells in Fancc-/- mice Blood. 104: 1204-1209 |
| Park SJ, Ciccone SL, Freie B, et al. (2004) A positive role for the Ku complex in DNA replication following strand break damage in mammals. The Journal of Biological Chemistry. 279: 6046-55 |
| Freie B, Li X, Ciccone SL, et al. (2003) Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis. Blood. 102: 4146-52 |