Brian K. Coombes, Ph.D.

2002 McMaster University, Hamilton, ON, Canada 
Microbiology Biology, Pathology
"Brian Coombes"


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James Mahony grad student 2002 McMaster University
 (Cellular and molecular host -pathogen interactions during Chlamydia pneumoniae infection.)
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Falconer SB, Reid-Yu SA, King AM, et al. (2016) Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae Acs Infectious Diseases. 1: 533-543
Oberc A, Coombes BK. (2015) Convergence of External Crohn's Disease Risk Factors on Intestinal Bacteria. Frontiers in Immunology. 6: 558
Ferreira RB, Valdez Y, Coombes BK, et al. (2015) A Highly Effective Component Vaccine against Nontyphoidal Salmonella enterica Infections. Mbio. 6
Reid-Yu SA, Tuinema BR, Small CN, et al. (2015) CXCL9 contributes to antimicrobial protection of the gut during citrobacter rodentium infection independent of chemokine-receptor signaling. Plos Pathogens. 11: e1004648
Mulder DT, McPhee JB, Reid-Yu SA, et al. (2015) Multiple histidines in the periplasmic domain of the Salmonella enterica sensor kinase SsrA enhance signaling in response to extracellular acidification. Molecular Microbiology. 95: 678-91
Tuinema BR, Reid-Yu SA, Coombes BK. (2014) Salmonella evades D-amino acid oxidase to promote infection in neutrophils. Mbio. 5: e01886
Allison SE, Tuinema BR, Everson ES, et al. (2014) Identification of the docking site between a type III secretion system ATPase and a chaperone for effector cargo. The Journal of Biological Chemistry. 289: 23734-44
King AM, Reid-Yu SA, Wang W, et al. (2014) Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. Nature. 510: 503-6
McPhee JB, Small CL, Reid-Yu SA, et al. (2014) Host defense peptide resistance contributes to colonization and maximal intestinal pathology by Crohn's disease-associated adherent-invasive Escherichia coli. Infection and Immunity. 82: 3383-93
Cooper CA, Mulder DT, Allison SE, et al. (2013) The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA. Bmc Microbiology. 13: 221
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