Jay L. Degen
Affiliations: | Cincinnati Children's Hospital, Cincinnati, OH, United States |
Area:
blood coagulation, genetics, inflammationGoogle:
"Jay Degen"Mean distance: 9.18 | S | N | B | C | P |
Parents
Sign in to add mentor| Jack E. Kyte | research assistant | Cincinnati Children's Hospital | |
| David R. Morris | grad student | Cincinnati Children's Hospital | |
| Edward Reich | post-doc | Cincinnati Children's Hospital |
Children
Sign in to add trainee| Matthew J. Flick | post-doc | 2000-2007 | Cincinnati Children's Hospital Medical Center |
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Publications
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| Negrón O, Hur WS, Prasad J, et al. (2022) Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection. Plos Pathogens. 18: e1010227 |
| Prasad JM, Negrón O, Du X, et al. (2021) Host fibrinogen drives antimicrobial function in peritonitis through bacterial-mediated prothrombin activation. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Gould TW, Dominguez B, de Winter F, et al. (2019) Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal. Plos Genetics. 15: e1007948 |
| Shaw MA, Gao Z, McElhinney KE, et al. (2017) Plasminogen deficiency delays the onset and protects from demyelination and paralysis in autoimmune neuroinflammatory disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience |
| Mignemi NA, Yuasa M, Baker CE, et al. (2016) Plasmin Prevents Dystrophic Calcification after Muscle Injury. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research |
| Shaw MA, Kombrinck KW, McElhinney KE, et al. (2016) Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice. Blood |
| Ryu JK, Petersen MA, Murray SG, et al. (2015) Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nature Communications. 6: 8164 |
| Yuasa M, Mignemi NA, Nyman JS, et al. (2015) Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification. The Journal of Clinical Investigation. 125: 3723 |
| Arumugam PI, Mullins ES, Shanmukhappa SK, et al. (2015) Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice. Blood. 126: 1844-55 |
| Prasad JM, Gorkun OV, Raghu H, et al. (2015) Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood |