| Year |
Citation |
Score |
| 2018 |
Dougan G, Dowson C, Overington J. Meeting the discovery challenge of drug-resistant infections: progress and focusing resources. Drug Discovery Today. PMID 30476550 DOI: 10.1016/J.Drudis.2018.11.015 |
0.317 |
|
| 2017 |
Tang J, Tanoli ZU, Ravikumar B, Alam Z, Rebane A, Vähä-Koskela M, Peddinti G, van Adrichem AJ, Wakkinen J, Jaiswal A, Karjalainen E, Gautam P, He L, Parri E, Khan S, ... ... Overington JP, et al. Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions. Cell Chemical Biology. PMID 29276046 DOI: 10.1016/j.chembiol.2017.11.009 |
0.33 |
|
| 2017 |
Tresadern G, Trabanco AA, Pérez-Benito L, Overington JP, van Vlijmen HWT, van Westen GJP. Identification of Allosteric Modulators of Metabotropic Glutamate 7 Receptor Using Proteochemometric Modeling. Journal of Chemical Information and Modeling. PMID 29172488 DOI: 10.1021/acs.jcim.7b00338 |
0.305 |
|
| 2017 |
Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP. Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach. Frontiers in Pharmacology. 8: 681. PMID 29018348 DOI: 10.3389/Fphar.2017.00681 |
0.543 |
|
| 2017 |
Finan C, Gaulton A, Kruger FA, Lumbers RT, Shah T, Engmann J, Galver L, Kelley R, Karlsson A, Santos R, Overington JP, Hingorani AD, Casas JP. The druggable genome and support for target identification and validation in drug development. Science Translational Medicine. 9. PMID 28356508 DOI: 10.1126/Scitranslmed.Aag1166 |
0.528 |
|
| 2016 |
Santos R, Ursu O, Gaulton A, Bento AP, Donadi RS, Bologa CG, Karlsson A, Al-Lazikani B, Hersey A, Oprea TI, Overington JP. A comprehensive map of molecular drug targets. Nature Reviews. Drug Discovery. PMID 27910877 DOI: 10.1038/nrd.2016.230 |
0.522 |
|
| 2016 |
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, et al. The ChEMBL database in 2017. Nucleic Acids Research. PMID 27899562 DOI: 10.1093/Nar/Gkw1074 |
0.315 |
|
| 2016 |
Mutowo P, Bento AP, Dedman N, Gaulton A, Hersey A, Lomax J, Overington JP. A drug target slim: using gene ontology and gene ontology annotations to navigate protein-ligand target space in ChEMBL. Journal of Biomedical Semantics. 7: 59. PMID 27678076 DOI: 10.1186/S13326-016-0102-0 |
0.339 |
|
| 2016 |
Bajorath J, Overington J, Jenkins JL, Walters P. Drug discovery and development in the era of Big Data. Future Medicinal Chemistry. PMID 27654148 DOI: 10.4155/Fmc-2014-0081 |
0.364 |
|
| 2015 |
Alvaro N, Conway M, Doan S, Lofi C, Overington J, Collier N. Crowdsourcing Twitter annotations to identify first-hand experiences of prescription drug use. Journal of Biomedical Informatics. PMID 26556646 DOI: 10.1016/J.Jbi.2015.11.004 |
0.344 |
|
| 2015 |
Cortés-Ciriano I, van Westen GJ, Bouvier G, Nilges M, Overington JP, Bender A, Malliavin TE. Improved large-scale prediction of growth inhibition patterns using the NCI60 cancer cell line panel. Bioinformatics (Oxford, England). PMID 26351271 DOI: 10.1093/Bioinformatics/Btv529 |
0.72 |
|
| 2015 |
Gaulton A, Kale N, van Westen GJ, Bellis LJ, Bento AP, Davies M, Hersey A, Papadatos G, Forster M, Wege P, Overington JP. A large-scale crop protection bioassay data set. Scientific Data. 2: 150032. PMID 26175909 DOI: 10.1038/Sdata.2015.32 |
0.721 |
|
| 2015 |
Mugumbate G, Overington JP. The relationship between target-class and the physicochemical properties of antibacterial drugs. Bioorganic & Medicinal Chemistry. PMID 25975639 DOI: 10.1016/j.bmc.2015.04.063 |
0.338 |
|
| 2015 |
Davies M, Dedman N, Hersey A, Papadatos G, Hall MD, Cucurull-Sanchez L, Jeffrey P, Hasan S, Eddershaw PJ, Overington JP. ADME SARfari: comparative genomics of drug metabolizing systems. Bioinformatics (Oxford, England). 31: 1695-7. PMID 25964657 DOI: 10.1093/bioinformatics/btv010 |
0.326 |
|
| 2015 |
Mugumbate G, Abrahams KA, Cox JA, Papadatos G, van Westen G, Lelièvre J, Calus ST, Loman NJ, Ballell L, Barros D, Overington JP, Besra GS. Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation. Plos One. 10: e0121492. PMID 25799414 DOI: 10.1371/Journal.Pone.0121492 |
0.717 |
|
| 2014 |
van Westen GJ, Bender A, Overington JP. Towards predictive resistance models for agrochemicals by combining chemical and protein similarity via proteochemometric modelling. Journal of Chemical Biology. 7: 119-23. PMID 25320644 DOI: 10.1007/S12154-014-0112-2 |
0.745 |
|
| 2014 |
Papadatos G, van Westen GJ, Croset S, Santos R, Trubian S, Overington JP. A document classifier for medicinal chemistry publications trained on the ChEMBL corpus. Journal of Cheminformatics. 6: 40. PMID 25221627 DOI: 10.1186/S13321-014-0040-8 |
0.746 |
|
| 2014 |
Dossetter AG, Ecker G, Laverty H, Overington J. 'Big data' in pharmaceutical science: challenges and opportunities. Future Medicinal Chemistry. 6: 857-64. PMID 24962278 DOI: 10.4155/Fmc.14.45 |
0.352 |
|
| 2014 |
Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L, Vasquez L, Valdes AM, ... ... Overington JP, et al. An atlas of genetic influences on human blood metabolites. Nature Genetics. 46: 543-50. PMID 24816252 DOI: 10.1038/Ng.2982 |
0.437 |
|
| 2014 |
van Westen GJ, Gaulton A, Overington JP. Chemical, target, and bioactive properties of allosteric modulation. Plos Computational Biology. 10: e1003559. PMID 24699297 DOI: 10.1371/journal.pcbi.1003559 |
0.714 |
|
| 2014 |
Bento AP, Gaulton A, Hersey A, Bellis LJ, Chambers J, Davies M, Krüger FA, Light Y, Mak L, McGlinchey S, Nowotka M, Papadatos G, Santos R, Overington JP. The ChEMBL bioactivity database: an update. Nucleic Acids Research. 42: D1083-90. PMID 24214965 DOI: 10.1093/Nar/Gkt1031 |
0.525 |
|
| 2013 |
Martínez-Jiménez F, Papadatos G, Yang L, Wallace IM, Kumar V, Pieper U, Sali A, Brown JR, Overington JP, Marti-Renom MA. Target prediction for an open access set of compounds active against Mycobacterium tuberculosis. Plos Computational Biology. 9: e1003253. PMID 24098102 DOI: 10.1371/Journal.Pcbi.1003253 |
0.484 |
|
| 2013 |
van Westen GJ, Swier RF, Cortes-Ciriano I, Wegner JK, Overington JP, Ijzerman AP, van Vlijmen HW, Bender A. Benchmarking of protein descriptor sets in proteochemometric modeling (part 2): modeling performance of 13 amino acid descriptor sets. Journal of Cheminformatics. 5: 42. PMID 24059743 DOI: 10.1186/1758-2946-5-42 |
0.751 |
|
| 2013 |
van Westen GJ, Overington JP. A ligand's-eye view of protein similarity. Nature Methods. 10: 116-7. PMID 23361090 DOI: 10.1038/nmeth.2339 |
0.664 |
|
| 2012 |
Kruger FA, Rostom R, Overington JP. Mapping small molecule binding data to structural domains. Bmc Bioinformatics. 13: S11. PMID 23282026 DOI: 10.1186/1471-2105-13-S17-S11 |
0.32 |
|
| 2012 |
Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic Acids Research. 40: D1100-7. PMID 21948594 DOI: 10.1093/Nar/Gkr777 |
0.342 |
|
| 2012 |
Wegner JK, Sterling A, Guha R, Bender A, Faulon JL, Hastings J, O'Boyle N, Overington J, Van Vlijmen H, Willighagen E. Cheminformatics Communications of the Acm. 55: 65-75. DOI: 10.1145/2366316.2366334 |
0.406 |
|
| 2011 |
Bellis LJ, Akhtar R, Al-Lazikani B, Atkinson F, Bento AP, Chambers J, Davies M, Gaulton A, Hersey A, Ikeda K, Krüger FA, Light Y, McGlinchey S, Santos R, Stauch B, ... Overington JP, et al. Collation and data-mining of literature bioactivity data for drug discovery. Biochemical Society Transactions. 39: 1365-70. PMID 21936816 DOI: 10.1042/Bst0391365 |
0.773 |
|
| 2011 |
Orchard S, Al-Lazikani B, Bryant S, Clark D, Calder E, Dix I, Engkvist O, Forster M, Gaulton A, Gilson M, Glen R, Grigorov M, Hammond-Kosack K, Harland L, Hopkins A, ... ... Overington J, et al. Minimum information about a bioactive entity (MIABE). Nature Reviews. Drug Discovery. 10: 661-9. PMID 21878981 DOI: 10.1038/Nrd3503 |
0.682 |
|
| 2011 |
Aranda B, Blankenburg H, Kerrien S, Brinkman FS, Ceol A, Chautard E, Dana JM, De Las Rivas J, Dumousseau M, Galeota E, Gaulton A, Goll J, Hancock RE, Isserlin R, Jimenez RC, ... ... Overington J, et al. PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nature Methods. 8: 528-9. PMID 21716279 DOI: 10.1038/Nmeth.1637 |
0.308 |
|
| 2011 |
van der Horst E, Peironcely JE, van Westen GJ, van den Hoven OO, Galloway WR, Spring DR, Wegner JK, van Vlijmen HW, Ijzerman AP, Overington JP, Bender A. Chemogenomics approaches for receptor deorphanization and extensions of the chemogenomics concept to phenotypic space. Current Topics in Medicinal Chemistry. 11: 1964-77. PMID 21470175 DOI: 10.2174/156802611796391230 |
0.761 |
|
| 2011 |
Hopkins AL, Bickerton GR, Carruthers IM, Boyer SK, Rubin H, Overington JP. Rapid analysis of pharmacology for infectious diseases. Current Topics in Medicinal Chemistry. 11: 1292-300. PMID 21401504 DOI: 10.2174/156802611795429130 |
0.668 |
|
| 2011 |
Gleeson MP, Hersey A, Montanari D, Overington J. Probing the links between in vitro potency, ADMET and physicochemical parameters. Nature Reviews. Drug Discovery. 10: 197-208. PMID 21358739 DOI: 10.1038/Nrd3367 |
0.374 |
|
| 2010 |
Abad-Zapatero C, Periši? O, Wass J, Bento AP, Overington J, Al-Lazikani B, Johnson ME. Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation. Drug Discovery Today. 15: 804-11. PMID 20727982 DOI: 10.1016/J.Drudis.2010.08.004 |
0.325 |
|
| 2009 |
Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey CR, Coghlan A, ... ... Overington JP, et al. The genome of the blood fluke Schistosoma mansoni. Nature. 460: 352-8. PMID 19606141 DOI: 10.1038/Nature08160 |
0.38 |
|
| 2009 |
Steinbeck C, Al-Lazikani B, Hermjakob H, Overington J, Thornton J. New open drug activity data at EBI Chemistry Central Journal. 3. DOI: 10.1186/1752-153X-3-S1-O3 |
0.34 |
|
| 2008 |
Agüero F, Al-Lazikani B, Aslett M, Berriman M, Buckner FS, Campbell RK, Carmona S, Carruthers IM, Chan AW, Chen F, Crowther GJ, Doyle MA, Hertz-Fowler C, Hopkins AL, McAllister G, ... ... Overington JP, et al. Genomic-scale prioritization of drug targets: the TDR Targets database. Nature Reviews. Drug Discovery. 7: 900-7. PMID 18927591 DOI: 10.1038/Nrd2684 |
0.726 |
|
| 2006 |
Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are there? Nature Reviews. Drug Discovery. 5: 993-6. PMID 17139284 DOI: 10.1038/nrd2199 |
0.66 |
|
| 2006 |
Hopkins AL, Mason JS, Overington JP. Can we rationally design promiscuous drugs? Current Opinion in Structural Biology. 16: 127-36. PMID 16442279 DOI: 10.1016/j.sbi.2006.01.013 |
0.644 |
|
| 2002 |
Michalovich D, Overington J, Fagan R. Protein sequence analysis in silico: application of structure-based bioinformatics to genomic initiatives. Current Opinion in Pharmacology. 2: 574-80. PMID 12324262 DOI: 10.1016/S1471-4892(02)00202-3 |
0.396 |
|
| 2002 |
Dumez E, Snaith JS, Jackson RF, McElroy AB, Overington J, Wythes MJ, Withka JM, McLellan TJ. Synthesis of macrocyclic, potential protease inhibitors using a generic scaffold. The Journal of Organic Chemistry. 67: 4882-92. PMID 12098301 DOI: 10.1021/Jo025615O |
0.341 |
|
| 2002 |
Danilewicz JC, Abel SM, Brown AD, Fish PV, Hawkeswood E, Holland SJ, James K, McElroy AB, Overington J, Powling MJ, Rance DJ. Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence. Journal of Medicinal Chemistry. 45: 2432-53. PMID 12036353 DOI: 10.1021/Jm011133D |
0.316 |
|
| 2002 |
Swindells MB, Overington JP. Prioritizing the proteome: identifying pharmaceutically relevant targets. Drug Discovery Today. 7: 516-21. PMID 11983568 DOI: 10.1016/S1359-6446(02)02250-X |
0.336 |
|
| 2001 |
Weir M, Swindells M, Overington J. Insights into protein function through large-scale computational analysis of sequence and structure. Trends in Biotechnology. 19: S61-6. PMID 11780973 DOI: 10.1016/S0167-7799(01)01794-2 |
0.375 |
|
| 1998 |
Sowdhamini R, Burke DF, Deane C, Huang JF, Mizuguchi K, Nagarajaram HA, Overington JP, Srinivasan N, Steward RE, Blundell TL. Protein three-dimensional structural databases: domains, structurally aligned homologues and superfamilies. Acta Crystallographica. Section D, Biological Crystallography. 54: 1168-77. PMID 10089493 DOI: 10.1107/S0907444998007148 |
0.623 |
|
| 1998 |
Mizuguchi K, Deane CM, Blundell TL, Overington JP. HOMSTRAD: a database of protein structure alignments for homologous families. Protein Science : a Publication of the Protein Society. 7: 2469-71. PMID 9828015 DOI: 10.1002/pro.5560071126 |
0.479 |
|
| 1998 |
Mizuguchi K, Deane CM, Blundell TL, Johnson MS, Overington JP. JOY: protein sequence-structure representation and analysis. Bioinformatics (Oxford, England). 14: 617-23. PMID 9730927 DOI: 10.1093/bioinformatics/14.7.617 |
0.453 |
|
| 1994 |
Donnelly D, Overington JP, Blundell TL. The prediction and orientation of alpha-helices from sequence alignments: the combined use of environment-dependent substitution tables, Fourier transform methods and helix capping rules. Protein Engineering. 7: 645-53. PMID 8073034 |
0.435 |
|
| 1994 |
Topham CM, Srinivasan N, Thorpe CJ, Overington JP, Kalsheker NA. Comparative modelling of major house dust mite allergen Der p I: structure validation using an extended environmental amino acid propensity table. Protein Engineering. 7: 869-94. PMID 7971950 DOI: 10.1093/Protein/7.7.869 |
0.497 |
|
| 1994 |
Sali A, Overington JP. Derivation of rules for comparative protein modeling from a database of protein structure alignments. Protein Science : a Publication of the Protein Society. 3: 1582-96. PMID 7833817 DOI: 10.1002/Pro.5560030923 |
0.515 |
|
| 1993 |
Johnson MS, Overington JP, Blundell TL. Alignment and searching for common protein folds using a data bank of structural templates. Journal of Molecular Biology. 231: 735-52. PMID 8515448 DOI: 10.1006/jmbi.1993.1323 |
0.492 |
|
| 1993 |
Donnelly D, Overington JP, Ruffle SV, Nugent JH, Blundell TL. Modeling alpha-helical transmembrane domains: the calculation and use of substitution tables for lipid-facing residues. Protein Science : a Publication of the Protein Society. 2: 55-70. PMID 8443590 DOI: 10.1002/pro.5560020106 |
0.437 |
|
| 1993 |
Topham CM, McLeod A, Eisenmenger F, Overington JP, Johnson MS, Blundell TL. Fragment ranking in modelling of protein structure. Conformationally constrained environmental amino acid substitution tables. Journal of Molecular Biology. 229: 194-220. PMID 8421300 DOI: 10.1006/jmbi.1993.1018 |
0.453 |
|
| 1993 |
Hoffrén AM, Saloheimo M, Thomas P, Overington JP, Johnson MS, Knowles JK, Blundell TL. Modelling of the lignin peroxidase LIII of Phlebia radiata: use of a sequence template generated from a 3-D structure. Protein Engineering. 6: 177-82. PMID 8386362 |
0.444 |
|
| 1993 |
Overington JP, Zhu ZY, Sali A, Johnson MS, Sowdhamini R, Louie GV, Blundell TL. Molecular recognition in protein families: a database of aligned three-dimensional structures of related proteins. Biochemical Society Transactions. 21: 597-604. PMID 8224474 DOI: 10.1042/Bst0210597 |
0.58 |
|
| 1992 |
Overington J. Structural constraints on residue substitution. Genetic Engineering. 14: 231-49. PMID 1368278 DOI: 10.1007/978-1-4615-3424-2_13 |
0.4 |
|
| 1992 |
Overington J, Donnelly D, Johnson MS, Sali A, Blundell TL. Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds. Protein Science : a Publication of the Protein Society. 1: 216-26. PMID 1304904 DOI: 10.1002/Pro.5560010203 |
0.631 |
|
| 1991 |
Hoffrén A, Saloheimo M, Thomas P, Overington J, Johnson M, Blundell T. Modelling the lignin peroxidase LIII of Phlebia radiata using a knowledge-based approach Journal De Chimie Physique. 88: 2659-2662. DOI: 10.1063/1.41321 |
0.507 |
|
| 1990 |
Topham CM, Overington J, Kowlessur D, Thomas M, Thomas EW, Brocklehurst K. Investigation of mechanistic consequences of natural structural variation within the cysteine proteinases by knowledge-based modelling and kinetic methods. Biochemical Society Transactions. 18: 579-80. PMID 2276446 DOI: 10.1042/Bst0180579 |
0.309 |
|
| 1990 |
Sali A, Overington JP, Johnson MS, Blundell TL. From comparisons of protein sequences and structures to protein modelling and design. Trends in Biochemical Sciences. 15: 235-40. PMID 2200167 DOI: 10.1016/0968-0004(90)90036-B |
0.593 |
|
| 1990 |
Topham CM, Thomas P, Overington JP, Johnson MS, Eisenmenger F, Blundell TL. An assessment of COMPOSER: a rule-based approach to modelling protein structure. Biochemical Society Symposium. 57: 1-9. PMID 2099735 |
0.442 |
|
| 1990 |
Overington J, Johnson MS, Sali A, Blundell TL. Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction. Proceedings. Biological Sciences / the Royal Society. 241: 132-45. PMID 1978340 DOI: 10.1098/Rspb.1990.0077 |
0.62 |
|
| 1990 |
Johnson M, Overington J, Šali A, Thomas P, Blundell T. From the comparative analysis of proteins to knowledge based modeling Journal of Molecular Graphics. 8: 231. DOI: 10.1016/0263-7855(90)80017-A |
0.513 |
|
| 1990 |
Johnson MS, Overington J, Sali A, Zhu Z, Donnelly D, Thomas P, McCleod A, Goold R, Topham C, Blundell TL. From comparative structure analysis to protein engineering: Knowledge-based protein modelling and design Fresenius' Journal of Analytical Chemistry. 337: 1-3. DOI: 10.1007/Bf00325709 |
0.348 |
|
| 1989 |
Lapatto R, Blundell T, Hemmings A, Overington J, Wilderspin A, Wood S, Merson JR, Whittle PJ, Danley DE, Geoghegan KF. X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes. Nature. 342: 299-302. PMID 2682266 DOI: 10.1038/342299A0 |
0.45 |
|
| 1989 |
Blundell TL, Elliott G, Gardner SP, Hubbard T, Islam S, Johnson M, Mantafounis D, Murray-Rust P, Overington J, Pitts JE. Protein engineering and design. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 324: 447-60. PMID 2573083 DOI: 10.1098/Rstb.1989.0059 |
0.504 |
|
| 1988 |
Blundell T, Carney D, Gardner S, Hayes F, Howlin B, Hubbard T, Overington J, Singh DA, Sibanda BL, Sutcliffe M. 18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design. European Journal of Biochemistry / Febs. 172: 513-20. PMID 3280310 DOI: 10.1111/J.1432-1033.1988.Tb13917.X |
0.562 |
|
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