| Year |
Citation |
Score |
| 2024 |
Urban MW, Charsar BA, Heinsinger NM, Markandaiah SS, Sprimont L, Zhou W, Brown EV, Henderson NT, Thomas SJ, Ghosh B, Cain RE, Trotti D, Pasinelli P, Wright MC, Dalva MB, et al. EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS. Elife. 12. PMID 38224498 DOI: 10.7554/eLife.89298 |
0.35 |
|
| 2023 |
Urban MW, Charsar BA, Heinsinger NM, Markandaiah SS, Sprimont L, Zhou W, Henderson NT, Ghosh B, Cain RE, Trotti D, Pasinelli P, Wright MC, Dalva MB, Lepore AC. EphrinB2 knockdown in spinal cord astrocytes preserves diaphragm innervation in a mutant SOD1 mouse model of ALS. Biorxiv : the Preprint Server For Biology. PMID 37215009 DOI: 10.1101/2023.05.10.538887 |
0.363 |
|
| 2022 |
Ghaffari LT, Trotti D, Haeusler AR, Jensen BK. Breakdown of the central synapses in C9orf72-linked ALS/FTD. Frontiers in Molecular Neuroscience. 15: 1005112. PMID 36187344 DOI: 10.3389/fnmol.2022.1005112 |
0.317 |
|
| 2022 |
Gleixner AM, Verdone BM, Otte CG, Anderson EN, Ramesh N, Shapiro OR, Gale JR, Mauna JC, Mann JR, Copley KE, Daley EL, Ortega JA, Cicardi ME, Kiskinis E, Kofler J, ... ... Trotti D, et al. NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility. Nature Communications. 13: 3380. PMID 35697676 DOI: 10.1038/s41467-022-31098-6 |
0.33 |
|
| 2022 |
Jensen BK, McAvoy KJ, Heinsinger NM, Lepore AC, Ilieva H, Haeusler AR, Trotti D, Pasinelli P. Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice. Glia. 70: 1426-1449. PMID 35474517 DOI: 10.1002/glia.24183 |
0.383 |
|
| 2022 |
Verdone BM, Cicardi ME, Wen X, Sriramoji S, Russell K, Markandaiah SS, Jensen BK, Krishnamurthy K, Haeusler AR, Pasinelli P, Trotti D. A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes. Scientific Reports. 12: 5644. PMID 35379876 DOI: 10.1038/s41598-022-09593-z |
0.33 |
|
| 2021 |
Cicardi ME, Marrone L, Azzouz M, Trotti D. Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis. The Embo Journal. e106389. PMID 33792056 DOI: 10.15252/embj.2020106389 |
0.304 |
|
| 2020 |
Jensen BK, Schuldi MH, McAvoy K, Russell KA, Boehringer A, Curran BM, Krishnamurthy K, Wen X, Westergard T, Ma L, Haeusler AR, Edbauer D, Pasinelli P, Trotti D. Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment. Embo Molecular Medicine. 12: e10722. PMID 32347002 DOI: 10.15252/Emmm.201910722 |
0.327 |
|
| 2019 |
Mohamed LA, Markandaiah SS, Bonanno S, Pasinelli P, Trotti D. Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis. Experimental Neurology. PMID 30974102 DOI: 10.1016/J.Expneurol.2019.04.002 |
0.363 |
|
| 2019 |
Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, Pasinelli P, Trotti D, Haeusler A. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. Embo Molecular Medicine. PMID 30617154 DOI: 10.15252/Emmm.201809423 |
0.326 |
|
| 2018 |
Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, ... ... Trotti D, et al. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nature Medicine. PMID 29400714 DOI: 10.1038/Nm.4490 |
0.399 |
|
| 2018 |
Kia A, McAvoy K, Krishnamurthy K, Trotti D, Pasinelli P. Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha. Glia. PMID 29380416 DOI: 10.1002/Glia.23298 |
0.356 |
|
| 2017 |
Rosenblum LT, Trotti D. EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis. Advances in Neurobiology. 16: 117-136. PMID 28828608 DOI: 10.1007/978-3-319-55769-4_6 |
0.527 |
|
| 2017 |
Rosenblum LT, Shamamandri-Markandaiah S, Ghosh B, Foran E, Lepore AC, Pasinelli P, Trotti D. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS. Experimental Neurology. PMID 28342750 DOI: 10.1016/J.Expneurol.2017.03.014 |
0.723 |
|
| 2016 |
Westergard T, Jensen BK, Wen X, Cai J, Kropf E, Iacovitti L, Pasinelli P, Trotti D. Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD. Cell Reports. 17: 645-652. PMID 27732842 DOI: 10.1016/J.Celrep.2016.09.032 |
0.305 |
|
| 2016 |
Qosa H, Lichter J, Sarlo M, Markandaiah SS, McAvoy K, Richard JP, Jablonski MR, Maragakis NJ, Pasinelli P, Trotti D. Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis. Glia. PMID 27158936 DOI: 10.1002/Glia.23003 |
0.316 |
|
| 2015 |
Qosa H, Miller DS, Pasinelli P, Trotti D. Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders. Brain Research. PMID 26187753 DOI: 10.1016/J.Brainres.2015.07.005 |
0.318 |
|
| 2015 |
Jablonski M, Miller DS, Pasinelli P, Trotti D. ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis. Brain Research. 1607: 1-14. PMID 25175835 DOI: 10.1016/J.Brainres.2014.08.060 |
0.405 |
|
| 2014 |
Wen X, Tan W, Westergard T, Krishnamurthy K, Markandaiah SS, Shi Y, Lin S, Shneider NA, Monaghan J, Pandey UB, Pasinelli P, Ichida JK, Trotti D. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron. 84: 1213-25. PMID 25521377 DOI: 10.1016/J.Neuron.2014.12.010 |
0.312 |
|
| 2014 |
Foran E, Rosenblum L, Bogush A, Pasinelli P, Trotti D. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization. Glia. 62: 1241-53. PMID 24753081 DOI: 10.1002/Glia.22677 |
0.758 |
|
| 2013 |
Foran E, Rosenblum L, Bogush AI, Trotti D. Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis. Neuromolecular Medicine. 15: 760-70. PMID 24062161 DOI: 10.1007/S12017-013-8262-X |
0.703 |
|
| 2012 |
Jablonski MR, Jacob DA, Campos C, Miller DS, Maragakis NJ, Pasinelli P, Trotti D. Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS. Neurobiology of Disease. 47: 194-200. PMID 22521463 DOI: 10.1016/J.Nbd.2012.03.040 |
0.385 |
|
| 2011 |
Foran E, Bogush A, Goffredo M, Roncaglia P, Gustincich S, Pasinelli P, Trotti D. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2. Glia. 59: 1719-31. PMID 21769946 DOI: 10.1002/Glia.21218 |
0.734 |
|
| 2010 |
Fieni F, Parkar A, Misgeld T, Kerschensteiner M, Lichtman JW, Pasinelli P, Trotti D. Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria. The Journal of Biological Chemistry. 285: 27411-7. PMID 20551319 DOI: 10.1074/Jbc.M110.131243 |
0.595 |
|
| 2009 |
Foran E, Trotti D. Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis. Antioxidants & Redox Signaling. 11: 1587-602. PMID 19413484 DOI: 10.1089/Ars.2009.2444 |
0.755 |
|
| 2008 |
Boston-Howes W, Williams EO, Bogush A, Scolere M, Pasinelli P, Trotti D. Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis. Experimental Neurology. 213: 229-37. PMID 18625223 DOI: 10.1016/J.Expneurol.2008.06.010 |
0.407 |
|
| 2007 |
Gibb SL, Boston-Howes W, Lavina ZS, Gustincich S, Brown RH, Pasinelli P, Trotti D. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 282: 32480-90. PMID 17823119 DOI: 10.1074/Jbc.M704314200 |
0.507 |
|
| 2006 |
Boston-Howes W, Gibb SL, Williams EO, Pasinelli P, Brown RH, Trotti D. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. The Journal of Biological Chemistry. 281: 14076-84. PMID 16567804 DOI: 10.1074/Jbc.M600653200 |
0.527 |
|
| 2004 |
Marciani P, Trotti D, Hediger MA, Monticelli G. Modulation of DMT1 Activity by Redox Compounds Journal of Membrane Biology. 197: 91-99. PMID 15014911 DOI: 10.1007/s00232-003-0644-9 |
0.489 |
|
| 2002 |
Trotti D. A role for glutamate transporters in neurodegenerative diseases. Advances in Experimental Medicine and Biology. 513: 225-48. PMID 12575823 |
0.435 |
|
| 2001 |
Trotti D, Peng JB, Dunlop J, Hediger MA. Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters Brain Research. 914: 196-203. PMID 11578612 DOI: 10.1016/S0006-8993(01)02802-5 |
0.651 |
|
| 2001 |
Gegelashvili G, Robinson MB, Trotti D, Rauen T. Regulation of glutamate transporters in health and disease. Progress in Brain Research. 132: 267-86. PMID 11544995 DOI: 10.1016/S0079-6123(01)32082-4 |
0.463 |
|
| 2001 |
Trotti D, Aoki M, Pasinelli P, Berger UV, Danbolt NC, Brown RH, Hediger MA. Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity Journal of Biological Chemistry. 276: 576-582. PMID 11031254 DOI: 10.1074/Jbc.M003779200 |
0.656 |
|
| 2001 |
Sacchi VF, Castagna M, Trotti D, Shayakul C, Hediger MA. Neutral amino acid absorption in the midgut of lepidopteran larvae Advances in Insect Physiology. 28: 168-184. DOI: 10.1016/S0065-2806(01)28010-2 |
0.507 |
|
| 1999 |
Trotti D, Rolfs A, Danbolt NC, Brown RH, Hediger MA. SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter Nature Neuroscience. 2: 427-433. PMID 10321246 DOI: 10.1038/8091 |
0.636 |
|
| 1998 |
Trotti D, Danbolt NC, Volterra A. Glutamate transporters are oxidant-vulnerable: A molecular link between oxidative and excitotoxic neurodegeneration? Trends in Pharmacological Sciences. 19: 328-334. PMID 9745361 DOI: 10.1016/S0165-6147(98)01230-9 |
0.513 |
|
| 1998 |
Castagna M, Shayakul C, Trotti D, Sacchi VF, Harvey WR, Hediger MA. Cloning and characterization of a potassium-coupled amino acid transporter. Proceedings of the National Academy of Sciences of the United States of America. 95: 5395-400. PMID 9560287 DOI: 10.1073/pnas.95.9.5395 |
0.521 |
|
| 1998 |
Peng JB, Chen XZ, Trotti D, Hediger MA. Mutations of amino acid residues that alter the chloride conductance of the human neuronal glutamate transporter EAAC1 Faseb Journal. 12. |
0.382 |
|
| 1997 |
Trotti D. Short communication differential modulation of the uptake currents by redox interconversion of cysteine residues in the human neuronal glutamate transporter EAAC1 European Journal of Neuroscience. 9: 2207-2212. PMID 9421181 DOI: 10.1111/J.1460-9568.1997.Tb01388.X |
0.542 |
|
| 1997 |
Coco S, Verderio C, Trotti D, Rothstein JD, Volterra A, Matteoli M. Non-synaptic localization of the glutamate transporter EAAC1 in cultured hippocampal neurons. The European Journal of Neuroscience. 9: 1902-10. PMID 9383213 DOI: 10.1111/J.1460-9568.1997.Tb00757.X |
0.448 |
|
| 1997 |
Trotti D, Rizzini BL, Rossi D, Haugeto O, Racagni G, Danbolt NC, Volterra A. Neuronal and glial glutamate transporters possess an SH-based redox regulatory mechanism European Journal of Neuroscience. 9: 1236-1243. PMID 9215707 DOI: 10.1111/J.1460-9568.1997.Tb01478.X |
0.554 |
|
| 1997 |
Castagna M, Shayakul C, Trotti D, Sacchi VF, Harvey WR, Hediger MA. Molecular characteristics of mammalian and insect amino acid transporters: implications for amino acid homeostasis. The Journal of Experimental Biology. 200: 269-86. PMID 9050235 |
0.366 |
|
| 1996 |
Volterra A, Bezzi P, Rizzini BL, Trotti D, Ullensvang K, Danbolt NC, Racagni G. The competitive transport inhibitor L-trans-pyrrolidine-2, 4-dicarboxylate triggers excitotoxicity in rat cortical neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition. The European Journal of Neuroscience. 8: 2019-28. PMID 8921292 DOI: 10.1111/J.1460-9568.1996.Tb01345.X |
0.531 |
|
| 1996 |
Trotti D, Rossi D, Gjesdal O, Levy LM, Racagni G, Danbolt NC, Volterra A. Peroxynitrite inhibits glutamate transporter subtypes Journal of Biological Chemistry. 271: 5976-5979. PMID 8626378 DOI: 10.1074/Jbc.271.11.5976 |
0.544 |
|
| 1995 |
Trotti D, Volterra A, Lehre KP, Rossi D, Gjesdal O, Racagni G, Danbolt NC. Arachidonic acid inhibits a purified and reconstituted glutamate transporter directly from the water phase and not via the phospholipid membrane Journal of Biological Chemistry. 270: 9890-9895. PMID 7730372 DOI: 10.1074/Jbc.270.17.9890 |
0.443 |
|
| 1995 |
Volterra A, Bezzi P, Lodi Rizzini B, Trotti D, Rossi D, Racagni G. S-22-5 Enhanced extracellular glutamate and delayed neurotoxicity in cortical neuroglial cocultures exposed to the glutamate uptake inhibitor PDC European Neuropsychopharmacology. 5: 224. DOI: 10.1016/0924-977X(95)90261-B |
0.456 |
|
| 1994 |
Volterra A, Trotti D, Racagni G. Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms Molecular Pharmacology. 46: 986-992. PMID 7969090 |
0.34 |
|
| 1994 |
Volterra A, Trotti D, Tromba C, Floridi S, Racagni G. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes Journal of Neuroscience. 14: 2924-2932. PMID 7910203 DOI: 10.1523/Jneurosci.14-05-02924.1994 |
0.506 |
|
| 1994 |
Volterra A, Trotti D, Floridi S, Racagni G. Reactive oxygen species inhibit high-affinity glutamate uptake: Molecular mechanism and neuropathological implications Annals of the New York Academy of Sciences. 738: 153-162. PMID 7832426 DOI: 10.1111/J.1749-6632.1994.Tb21800.X |
0.374 |
|
| 1994 |
Racagni G, Riva M, Trotti D, Volterra A. Modulation of glutamate uptake by oxygen free radicals and changes in the expression of NMDA receptor subunits: relevance to neurotoxicity European Neuropsychopharmacology. 4: 261-262. DOI: 10.1016/0924-977X(94)90081-7 |
0.403 |
|
| 1993 |
Volterra A, Trotti D, Floridi S, Mazza F, Racagni G. Inhibition of high-affinity glutamate uptake by arachidonic acid and oxygen free radicals: physiopathological significance European Neuropsychopharmacology. 3: 182-183. DOI: 10.1016/0924-977X(93)90014-D |
0.424 |
|
| 1992 |
Volterra A, Trotti D, Cassutti P, Tromba C, Salvaggio A, Melcangi RC, Racagni G. High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes Journal of Neurochemistry. 59: 600-606. PMID 1629731 DOI: 10.1111/J.1471-4159.1992.Tb09411.X |
0.457 |
|
| 1992 |
Volterra A, Trotti D, Cassutti P, Tromba C, Galimberti R, Lecchi P, Racagni G. A role for the arachidonic acid cascade in fast synaptic modulation: Ion channels and transmitter uptake systems as target proteins Advances in Experimental Medicine and Biology. 318: 147-158. PMID 1378992 DOI: 10.1007/978-1-4615-3426-6_13 |
0.461 |
|
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