Timothy A. Mietzner - Publications

Affiliations: 
University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Biochemistry, Microbiology Biology

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Paranjape SM, Lauer TW, Montelaro RC, Mietzner TA, Vij N. Modulation of proinflammatory activity by the engineered cationic antimicrobial peptide WLBU-2. F1000research. 2: 36. PMID 24555033 DOI: 10.12688/F1000Research.2-36.V1  0.44
2013 Deslouches B, Steckbeck JD, Craigo JK, Doi Y, Mietzner TA, Montelaro RC. Rational design of engineered cationic antimicrobial peptides consisting exclusively of arginine and tryptophan, and their activity against multidrug-resistant pathogens. Antimicrobial Agents and Chemotherapy. 57: 2511-21. PMID 23507278 DOI: 10.1128/Aac.02218-12  0.44
2012 Parker Siburt CJ, Mietzner TA, Crumbliss AL. FbpA--a bacterial transferrin with more to offer. Biochimica Et Biophysica Acta. 1820: 379-92. PMID 21933698 DOI: 10.1016/J.Bbagen.2011.09.001  0.44
2010 Weaver KD, Gabricevi? M, Anderson DS, Adhikari P, Mietzner TA, Crumbliss AL. Role of citrate and phosphate anions in the mechanism of iron(III) sequestration by ferric binding protein: kinetic studies of the formation of the holoprotein of wild-type FbpA and its engineered mutants. Biochemistry. 49: 6021-32. PMID 20496864 DOI: 10.1021/Bi902231C  0.44
2010 Skinner MC, Kiselev AO, Isaacs CE, Mietzner TA, Montelaro RC, Lampe MF. Evaluation of WLBU2 peptide and 3-O-octyl-sn-glycerol lipid as active ingredients for a topical microbicide formulation targeting Chlamydia trachomatis Antimicrobial Agents and Chemotherapy. 54: 627-636. PMID 20008784 DOI: 10.1128/Aac.00635-09  0.44
2010 Heymann JJ, Gabricevi? M, Mietzner TA, Crumbliss AL. Kinetics and mechanism of exogenous anion exchange in FeFbpA-NTA: significance of periplasmic anion lability and anion binding activity of ferric binding protein A. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 237-48. PMID 19813031 DOI: 10.1007/S00775-009-0589-2  0.44
2009 Siburt CJ, Roulhac PL, Weaver KD, Noto JM, Mietzner TA, Cornelissen CN, Fitzgerald MC, Crumbliss AL. Hijacking transferrin bound iron: protein-receptor interactions involved in iron transport in N. gonorrhoeae. Metallomics : Integrated Biometal Science. 1: 249-55. PMID 20161024 DOI: 10.1039/B902860A  0.44
2009 Chan YR, Liu JS, Pociask DA, Zheng M, Mietzner TA, Berger T, Mak TW, Clifton MC, Strong RK, Ray P, Kolls JK. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. Journal of Immunology (Baltimore, Md. : 1950). 182: 4947-56. PMID 19342674 DOI: 10.4049/Jimmunol.0803282  0.44
2008 Weaver KD, Heymann JJ, Mehta A, Roulhac PL, Anderson DS, Nowalk AJ, Adhikari P, Mietzner TA, Fitzgerald MC, Crumbliss AL. Ga3+ as a mechanistic probe in Fe3+ transport: characterization of Ga3+ interaction with FbpA. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 13: 887-98. PMID 18461372 DOI: 10.1007/S00775-008-0376-5  0.44
2008 Roulhac PL, Weaver KD, Adhikari P, Anderson DS, DeArmond PD, Mietzner TA, Crumbliss AL, Fitzgerald MC. Ex vivo analysis of synergistic anion binding to FbpA in Gram-negative bacteria. Biochemistry. 47: 4298-305. PMID 18338854 DOI: 10.1021/Bi701188X  0.44
2007 Heymann JJ, Weaver KD, Mietzner TA, Crumbliss AL. Sulfate as a synergistic anion facilitating iron binding by the bacterial transferrin FbpA: the origins and effects of anion promiscuity. Journal of the American Chemical Society. 129: 9704-12. PMID 17630737 DOI: 10.1021/Ja0709268  0.44
2007 Deslouches B, Gonzalez IA, DeAlmeida D, Islam K, Steele C, Montelaro RC, Mietzner TA. De novo-derived cationic antimicrobial peptide activity in a murine model of Pseudomonas aeruginosa bacteraemia. The Journal of Antimicrobial Chemotherapy. 60: 669-72. PMID 17623696 DOI: 10.1093/Jac/Dkm253  0.44
2007 Anderson DS, Adhikari P, Weaver KD, Crumbliss AL, Mietzner TA. The Haemophilus influenzae hFbpABC Fe3+ transporter: analysis of the membrane permease and development of a gallium-based screen for mutants. Journal of Bacteriology. 189: 5130-41. PMID 17496104 DOI: 10.1128/Jb.00145-07  0.44
2007 Novak KF, Diamond WJ, Kirakodu S, Peyyala R, Anderson KW, Montelaro RC, Mietzner TA. Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria. Antimicrobial Agents and Chemotherapy. 51: 1837-9. PMID 17325219 DOI: 10.1128/Aac.00924-06  0.44
2006 Isaacs CE, Rohan L, Xu W, Jia JH, Mietzner T, Hillier S. Inactivation of herpes simplex virus clinical isolates by using a combination microbicide Antimicrobial Agents and Chemotherapy. 50: 1063-1066. PMID 16495269 DOI: 10.1128/Aac.50.3.1063-1066.2006  0.44
2005 Deslouches B, Islam K, Craigo JK, Paranjape SM, Montelaro RC, Mietzner TA. Activity of the de novo engineered antimicrobial peptide WLBU2 against Pseudomonas aeruginosa in human serum and whole blood: implications for systemic applications. Antimicrobial Agents and Chemotherapy. 49: 3208-16. PMID 16048927 DOI: 10.1128/Aac.49.8.3208-3216.2005  0.44
2005 Dhungana S, Anderson DS, Mietzner TA, Crumbliss AL. Kinetics of iron release from ferric binding protein (FbpA): mechanistic implications in bacterial periplasm-to-cytosol Fe3+ transport. Biochemistry. 44: 9606-18. PMID 16008346 DOI: 10.1021/Bi0505518  0.44
2005 Phadke SM, Deslouches B, Hileman SE, Montelaro RC, Wiesenfeld HC, Mietzner TA. Antimicrobial peptides in mucosal secretions: the importance of local secretions in mitigating infection. The Journal of Nutrition. 135: 1289-93. PMID 15867326 DOI: 10.1093/Jn/135.5.1289  0.44
2005 Deslouches B, Phadke SM, Lazarevic V, Cascio M, Islam K, Montelaro RC, Mietzner TA. De novo generation of cationic antimicrobial peptides: influence of length and tryptophan substitution on antimicrobial activity. Antimicrobial Agents and Chemotherapy. 49: 316-22. PMID 15616311 DOI: 10.1128/Aac.49.1.316-322.2005  0.44
2004 Roulhac PL, Powell KD, Dhungana S, Weaver KD, Mietzner TA, Crumbliss AL, Fitzgerald MC. SUPREX (Stability of Unpurified Proteins from Rates of H/D Exchange) analysis of the thermodynamics of synergistic anion binding by ferric-binding protein (FbpA), a bacterial transferrin. Biochemistry. 43: 15767-74. PMID 15595832 DOI: 10.1021/Bi0481848  0.44
2004 Dhungana S, Anderson DS, Mietzner TA, Crumbliss AL. Phosphate ester hydrolysis is catalyzed by a bacterial transferrin: potential implications for in vivo iron transport mechanisms. Journal of Inorganic Biochemistry. 98: 1975-7. PMID 15522424 DOI: 10.1016/J.Jinorgbio.2004.08.004  0.44
2004 Anderson DS, Adhikari P, Nowalk AJ, Chen CY, Mietzner TA. The hFbpABC transporter from Haemophilus influenzae functions as a binding-protein-dependent ABC transporter with high specificity and affinity for ferric iron. Journal of Bacteriology. 186: 6220-9. PMID 15342592 DOI: 10.1128/Jb.186.18.6220-6229.2004  0.44
2004 Gabricevi? M, Anderson DS, Mietzner TA, Crumbliss AL. Kinetics and mechanism of iron(III) complexation by ferric binding protein: the role of phosphate. Biochemistry. 43: 5811-9. PMID 15134455 DOI: 10.1021/Bi036217Y  0.44
2003 Phadke SM, Islam K, Deslouches B, Kapoor SA, Beer Stolz D, Watkins SC, Montelaro RC, Pilewski JM, Mietzner TA. Selective toxicity of engineered lentivirus lytic peptides in a CF airway cell model. Peptides. 24: 1099-107. PMID 14612179 DOI: 10.1016/J.Peptides.2003.07.001  0.44
2003 Boukhalfa H, Anderson DS, Mietzner TA, Crumbliss AL. Kinetics and mechanism of iron release from the bacterial ferric binding protein nFbp: exogenous anion influence and comparison with mammalian transferrin. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 8: 881-92. PMID 14551810 DOI: 10.1007/S00775-003-0487-Y  0.44
2003 Dhungana S, Taboy CH, Anderson DS, Vaughan KG, Aisen P, Mietzner TA, Crumbliss AL. The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin. Proceedings of the National Academy of Sciences of the United States of America. 100: 3659-64. PMID 12646708 DOI: 10.1073/Pnas.0536897100  0.44
2002 Phadke SM, Lazarevic V, Bahr CC, Islam K, Stolz DB, Watkins S, Tencza SB, Vogel HJ, Montelaro RC, Mietzner TA. Lentivirus lytic peptide 1 perturbs both outer and inner membranes of Serratia marcescens. Antimicrobial Agents and Chemotherapy. 46: 2041-5. PMID 12019137 DOI: 10.1128/Aac.46.6.2041-2045.2002  0.44
2001 Bruns CM, Anderson DS, Vaughan KG, Williams PA, Nowalk AJ, McRee DE, Mietzner TA. Crystallographic and biochemical analyses of the metal-free Haemophilus influenzae Fe3+-binding protein. Biochemistry. 40: 15631-7. PMID 11747438 DOI: 10.1021/Bi0156759  0.44
2001 Yuan T, Tencza S, Mietzner TA, Montelaro RC, Vogel HJ. Calmodulin binding properties of peptide analogues and fragments of the calmodulin-binding domain of simian immunodeficiency virus transmembrane glycoprotein 41 Biopolymers. 58: 50-62. PMID 11072229 DOI: 10.1002/1097-0282(200101)58:1<50::Aid-Bip60>3.0.Co;2-S  0.44
2001 Taboy CH, Vaughan KG, Mietzner TA, Aisen P, Crumbliss AL. Fe3+ coordination and redox properties of a bacterial transferrin. The Journal of Biological Chemistry. 276: 2719-24. PMID 11029460 DOI: 10.1074/Jbc.M004763200  0.44
1999 Plymale DR, Comardelle AM, Fermi CD, Martin DS, Costin JM, Norris CH, Tencza SB, Mietzner TA, Montelaro RC, Garry RF. Concentration-dependent differential induction of necrosis or apoptosis by HIV-1 lytic peptide 1. Peptides. 20: 1275-83. PMID 10612441 DOI: 10.1016/S0196-9781(99)00132-1  0.44
1999 Tencza SB, Creighton DJ, Yuan T, Vogel HJ, Montelaro RC, Mietzner TA. Lentivirus-derived antimicrobial peptides: Increased potency by sequence engineering and dimerization Journal of Antimicrobial Chemotherapy. 44: 33-41. PMID 10459808 DOI: 10.1093/Jac/44.1.33  0.44
1999 Chakraborty A, Dyer KF, Cascio M, Mietzner TA, Tweardy DJ. Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor. Blood. 93: 15-24. PMID 9864141 DOI: 10.1182/Blood.V93.1.15.401A46_15_24  0.44
1998 Beary TP, Tencza SB, Mietzner TA, Montelaro RC. Interruption of T-cell signal transduction by lentivirus lytic peptides from HIV-1 transmembrane protein Journal of Peptide Research. 51: 75-79. PMID 9495594 DOI: 10.1111/J.1399-3011.1998.Tb00419.X  0.44
1997 Comardelle AM, Norris CH, Plymale DR, Gatti PJ, Choi B, Fermin CD, Haislip AM, Tencza SB, Mietzner TA, Montelaro RC, Garry RF. A synthetic peptide corresponding to the carboxy terminus of human immunodeficiency virus type 1 transmembrane glycoprotein induces alterations in the ionic permeability of Xenopus laevis oocytes. Aids Research and Human Retroviruses. 13: 1525-32. PMID 9390752 DOI: 10.1089/Aid.1997.13.1525  0.44
1997 Mietzner TA, Tencza SB, Adhikari P, Vaughan KG, Nowalk AJ. Fe(III) periplasm-to-cytosol transporters of gram-negative pathogens Current Topics in Microbiology and Immunology. 225: 113-135. PMID 9386331 DOI: 10.1007/978-3-642-80451-9_7  0.44
1997 Tencza SB, Douglass JP, Creighton DJ, Montelaro RC, Mietzner TA. Novel antimicrobial peptides derived from human immunodeficiency virus type 1 and other lentivirus transmembrane proteins Antimicrobial Agents and Chemotherapy. 41: 2394-2398. PMID 9371339 DOI: 10.1128/Aac.41.11.2394  0.44
1997 Bruns CM, Nowalk AJ, Arvai AS, McTigue MA, Vaughan KG, Mietzner TA, McRee DE. Structure of Haemophilus influenzae Fe+3-binding protein reveals convergent evolution within a superfamily Nature Structural Biology. 4: 919-924. PMID 9360608 DOI: 10.1038/Nsb1197-919  0.44
1997 Nowalk AJ, Vaughan KG, Day BW, Tencza SB, Mietzner TA. Metal-dependent conformers of the periplasmic ferric ion binding protein. Biochemistry. 36: 13054-9. PMID 9335567 DOI: 10.1021/Bi971413O  0.44
1997 Tencza SB, Mietzner TA, Montelaro RC. Calmodulin-binding function of LLP segments from the HIV type 1 transmembrane protein is conserved among natural sequence variants Aids Research and Human Retroviruses. 13: 263-269. PMID 9115814 DOI: 10.1089/Aid.1997.13.263  0.44
1996 Feili-Hariri M, Kao H, Mietzner TA, Morel PA. Functional consequences of the binding of MHC class II-derived peptides to MHC class II International Immunology. 8: 1857-1865. PMID 8982770 DOI: 10.1093/intimm/8.12.1857  0.44
1996 Adhikari P, Berish SA, Nowalk AJ, Veraldi KL, Morse SA, Mietzner TA. The fbpABC locus of Neisseria gonorrhoeae functions in the periplasm-to-cytosol transport of iron Journal of Bacteriology. 178: 2145-2149. PMID 8606197 DOI: 10.1128/Jb.178.7.2145-2149.1996  0.44
1995 Tencza SB, Miller MA, Islam K, Mietzner TA, Montelaro RC. Effect of amino acid substitutions on calmodulin binding and cytolytic properties of the LLP-1 peptide segment of human immunodeficiency virus type 1 transmembrane protein Journal of Virology. 69: 5199-5202. PMID 7609094 DOI: 10.1128/Jvi.69.8.5199-5202.1995  0.44
1995 Adhikari P, Kirby SD, Nowalk AJ, Veraldi KL, Schryvers AB, Mietzner TA. Biochemical characterization of a Haemophilus influenzae periplasmic iron transport operon. The Journal of Biological Chemistry. 270: 25142-9. PMID 7559648 DOI: 10.1074/Jbc.270.42.25142  0.44
1994 Mietzner TA, Morse SA. The role of iron-binding proteins in the survival of pathogenic bacteria Annual Review of Nutrition. 14: 471-493. PMID 7946530 DOI: 10.1146/Annurev.Nu.14.070194.002351  0.44
1993 Miller MA, Cloyd MW, Liebmann J, Rinaldo CR, Islam KR, Wang SZ, Mietzner TA, Montelaro RC. Alterations in cell membrane permeability by the lentivirus lytic peptide (LLP-1) of HIV-1 transmembrane protein. Virology. 196: 89-100. PMID 8356808 DOI: 10.1006/Viro.1993.1457  0.44
1993 Miller MA, Mietzner TA, Cloyd MW, Robey WG, Montelaro RC. Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein Aids Research and Human Retroviruses. 9: 1057-1066. PMID 8312049 DOI: 10.1089/Aid.1993.9.1057  0.44
1993 Chen CY, Berish SA, Morse SA, Mietzner TA. The ferric iron-binding protein of pathogenic Neisseria spp. functions as a periplasmic transport protein in iron acquisition from human transferrin Molecular Microbiology. 10: 311-318. PMID 7934822 DOI: 10.1111/J.1365-2958.1993.Tb01957.X  0.44
1992 Mietzner TA, Kokai-Kun JF, Hanna PC, McClane BA. A conjugated synthetic peptide corresponding to the C-terminal region of Clostridium perfringens type A enterotoxin elicits an enterotoxin- neutralizing antibody response in mice Infection and Immunity. 60: 3947-3951. PMID 1500207 DOI: 10.1128/Iai.60.9.3947-3951.1992  0.44
1992 Berish SA, Chen CY, Mietzner TA, Morse SA. Expression of a functional neisserial fbp gene in Escherichia coli Molecular Microbiology. 6: 2607-2615. PMID 1447971 DOI: 10.1111/J.1365-2958.1992.Tb01438.X  0.44
1992 Hanna PC, Wieckowski EU, Mietzner TA, McClane BA. Mapping of functional regions of Clostridium perfringens type A enterotoxin Infection and Immunity. 60: 2110-2114. PMID 1373406 DOI: 10.1128/Iai.60.5.2110-2114.1992  0.44
1991 Hanna PC, Mietzner TA, Schoolnik GK, McClane BA. Localization of the receptor-binding region of Clostridium perfringens enterotoxin utilizing cloned toxin fragments and synthetic peptides: The 30 C-terminal amino acids define a functional binding region Journal of Biological Chemistry. 266: 11037-11043. PMID 1645721  0.44
1990 Berish SA, Mietzner TA, Mayer LW, Genco CA, Holloway BP, Morse SA. Molecular cloning and characterization of the structural gene for the major iron-regulated protein expressed by Neisseria gonorrhoeae Journal of Experimental Medicine. 171: 1535-1546. PMID 2110241 DOI: 10.1084/Jem.171.5.1535  0.44
1990 Ho ASY, Mietzner TA, Smith AJ, Schoolnik GK. The pili of Aeromonas hydrophila: Identification of an environmentally regulated "mini pilin" Journal of Experimental Medicine. 172: 795-806. PMID 1974915 DOI: 10.1084/Jem.172.3.795  0.44
1988 Morse SA, Chen CY, LeFaou A, Mietzner TA. A potential role for the major iron-regulated protein expressed by pathogenic Neisseria species Reviews of Infectious Diseases. 10. PMID 3142015 DOI: 10.1093/Cid/10.Supplement_2.S306  0.44
1987 Mietzner TA, Bolan G, Schoolnik GK, Morse SA. Purification and characterization of the major iron-regulated protein expressed by pathogenic Neisseriae Journal of Experimental Medicine. 165: 1041-1057. PMID 3559476 DOI: 10.1084/Jem.165.4.1041  0.44
1987 Morse SA, Mietzner TA, Bolen G, Le Faou A, Schoolnik G. Characterization of the major iron-regulated protein of Neisseria gonorrhoeae and Neissereria meningitidis Antonie Van Leeuwenhoek. 53: 465-469. PMID 3130784 DOI: 10.1007/Bf00415504  0.44
1987 Fohn MJ, Mietzner TA, Hubbard TW, Morse SA, Hook EW. Human immunoglobulin G antibody response to the major gonococcal iron-regulated protein Infection and Immunity. 55: 3065-3069. PMID 3119496  0.44
1986 Mietzner TA, Barnes RC, Jeanlouis YA, Shafer WM, Morse SA. Distribution of an antigenically related iron-regulated protein among the Neisseria spp Infection and Immunity. 51: 60-68. PMID 3941006 DOI: 10.1128/Iai.51.1.60-68.1986  0.44
1986 Gariepy J, Mietzner TA, Schoolnik GK. Peptide antisera as sequence-specific probes of protein conformational transitions: Calmodulin exhibits calcium-dependent changes in antigenicity Proceedings of the National Academy of Sciences of the United States of America. 83: 8888-8892. PMID 2431410 DOI: 10.1073/Pnas.83.23.8888  0.44
1984 Mietzner TA, Luginbuhl GH, Sandstrom E, Morse SA. Identification of an iron-regulated 37,000-dalton protein in the cell envelope of Neisseria gonorrhoeae Infection and Immunity. 45: 410-416. PMID 6430806 DOI: 10.1128/Iai.45.2.410-416.1984  0.44
1983 McFarland L, Mietzner TA, Knapp JS, Sandstrom E, Holmes KK, Morse SA. Gonococcal sensitivity to fecal lipids can be mediated by an Mtr-independent mechanism Journal of Clinical Microbiology. 18: 121-127. PMID 6411761 DOI: 10.1128/Jcm.18.1.121-127.1983  0.44
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