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Marc Ouellette - Publications

Affiliations: 
Universite Laval (Canada) 
Area:
Microbiology Biology
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179 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Queffeulou M, Leprohon P, Fernandez-Prada C, Ouellette M, Mejía-Jaramillo AM. CRISPR-Cas9 high-throughput screening to study drug resistance in . Mbio. e0047724. PMID 38864609 DOI: 10.1128/mbio.00477-24  0.328
2024 Telhig S, Pham NP, Ben Said L, Rebuffat S, Ouellette M, Zirah S, Fliss I. Exploring the genetic basis of natural resistance to microcins. Microbial Genomics. 10. PMID 38407259 DOI: 10.1099/mgen.0.001156  0.362
2023 Potvin JÉ, Fani F, Queffeulou M, Gazanion É, Leprohon P, Ouellette M. Increased copy number of the target gene squalene monooxygenase as the main resistance mechanism to terbinafine in Leishmania infantum. International Journal For Parasitology. Drugs and Drug Resistance. 23: 37-43. PMID 37703646 DOI: 10.1016/j.ijpddr.2023.09.001  0.411
2023 Gingras H, Peillard-Fiorente F, Godin C, Patron K, Leprohon P, Ouellette M. New Resistance Mutations Linked to Decreased Susceptibility to Solithromycin in Streptococcus pneumoniae Revealed by Chemogenomic Screens. Antimicrobial Agents and Chemotherapy. e0039523. PMID 37409958 DOI: 10.1128/aac.00395-23  0.306
2023 Bigot S, Leprohon P, Ouellette M. Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection. Plos Neglected Tropical Diseases. 17: e0011458. PMID 37384801 DOI: 10.1371/journal.pntd.0011458  0.411
2022 Bigot S, Leprohon P, Vasquez A, Bhadoria R, Skouta R, Ouellette M. Thiophene derivatives activity against the protozoan parasite Leishmania infantum. International Journal For Parasitology. Drugs and Drug Resistance. 21: 13-20. PMID 36525934 DOI: 10.1016/j.ijpddr.2022.11.004  0.36
2022 Fujii TTS, Gomes PS, do Monte-Neto RL, de Oliveira Gomes DC, Ouellette M, Torres-Santos EC, Andrade-Neto VV, de Matos Guedes HL. Simvastatin Resistance of Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors. Microorganisms. 10. PMID 35208853 DOI: 10.3390/microorganisms10020398  0.393
2021 Roy G, Bhattacharya A, Leprohon P, Ouellette M. Decreased glutamate transport in acivicin resistant Leishmania tarentolae. Plos Neglected Tropical Diseases. 15: e0010046. PMID 34914690 DOI: 10.1371/journal.pntd.0010046  0.439
2021 Van den Kerkhof M, Leprohon P, Mabille D, Hendrickx S, Tulloch LB, Wall RJ, Wyllie S, Chatelain E, Mowbray CE, Braillard S, Ouellette M, Maes L, Caljon G. Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series. Microorganisms. 9. PMID 34210040 DOI: 10.3390/microorganisms9071408  0.409
2021 Bhattacharya A, Leprohon P, Ouellette M. Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum. Plos Neglected Tropical Diseases. 15: e0009377. PMID 33905412 DOI: 10.1371/journal.pntd.0009377  0.348
2020 Gingras H, Patron K, Leprohon P, Ouellette M. Azithromycin resistance mutations in as revealed by a chemogenomic screen. Microbial Genomics. PMID 33074087 DOI: 10.1099/mgen.0.000454  0.344
2020 Potvin JE, Leprohon P, Queffeulou M, Sundar S, Ouellette M. Mutations in an aquaglyceroporin as a proven marker of antimony clinical resistance in the parasite Leishmania donovani. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 32827255 DOI: 10.1093/Cid/Ciaa1236  0.46
2020 Van den Kerkhof M, Mabille D, Hendrickx S, Leprohon P, Mowbray CE, Braillard S, Ouellette M, Maes L, Caljon G. ANTILEISHMANIAL AMINOPYRAZOLES: STUDIES INTO MECHANISMS AND STABILITY OF EXPERIMENTAL DRUG RESISTANCE. Antimicrobial Agents and Chemotherapy. PMID 32601168 DOI: 10.1128/Aac.00152-20  0.503
2020 Douanne N, Wagner V, Roy G, Leprohon P, Ouellette M, Fernandez-Prada C. MRPA-independent mechanisms of antimony resistance in Leishmania infantum. International Journal For Parasitology. Drugs and Drug Resistance. 13: 28-37. PMID 32413766 DOI: 10.1016/J.Ijpddr.2020.03.003  0.575
2020 Ouellette M, Bhattacharya A. Exploiting antimicrobial resistance: Better knowledge of resistance mechanisms can inform the search for and development of new antibiotics. Embo Reports. e50249. PMID 32159920 DOI: 10.15252/Embr.202050249  0.451
2020 Bhattacharya A, Bigot S, Padmanabhan PK, Mukherjee A, Coelho A, Leprohon P, Papadopoulou B, Ouellette M. New insights in the mode of action of anti-leishmanial drugs by using chemical mutagenesis screens coupled to next-generation sequencing. Microbial Cell (Graz, Austria). 7: 59-61. PMID 32025514 DOI: 10.15698/Mic2020.02.708  0.501
2019 Bhattacharya A, Leprohon P, Bigot S, Padmanabhan PK, Mukherjee A, Roy G, Gingras H, Mestdagh A, Papadopoulou B, Ouellette M. Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania. Nature Communications. 10: 5627. PMID 31819054 DOI: 10.1038/S41467-019-13344-6  0.52
2019 El Khoury JY, Maure A, Gingras H, Leprohon P, Ouellette M. Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria. Msystems. 4. PMID 31744905 DOI: 10.1128/mSystems.00465-19  0.419
2019 Bhattacharya A, Sharma M, Pakkinathan C, Rosen BP, Leprohon P, Ouellette M. Genomewide Analysis of Mode of Action of the -Adenosylmethionine Analogue Sinefungin in Leishmania infantum. Msystems. 4. PMID 31615876 DOI: 10.1128/mSystems.00416-19  0.355
2019 Wallace RL, Ouellette M, Jean J. Effect of UV-C light or hydrogen peroxide wipes on the inactivation of methicillin-resistant Staphylococcus aureus, Clostridium difficile spores, and norovirus surrogate. Journal of Applied Microbiology. PMID 31077510 DOI: 10.1111/Jam.14308  0.317
2019 Potvin JE, Leprohon P, Gazanion E, Sharma M, Fernandez-Prada C, Ouellette M. Cos-Seq: A High-Throughput Gain-of-Function Screen for Drug Resistance Studies in Leishmania. Methods in Molecular Biology (Clifton, N.J.). 1971: 141-167. PMID 30980302 DOI: 10.1007/978-1-4939-9210-2_7  0.423
2019 Raymond F, Boissinot M, Ouameur AA, Déraspe M, Plante PL, Kpanou SR, Bérubé È, Huletsky A, Roy PH, Ouellette M, Bergeron MG, Corbeil J. Culture-enriched human gut microbiomes reveal core and accessory resistance genes. Microbiome. 7: 56. PMID 30953542 DOI: 10.1186/S40168-019-0669-7  0.474
2019 Gingras H, Patron K, Bhattacharya A, Leprohon P, Ouellette M. Gain and loss of function screens coupled to next generation sequencing for antibiotic mode of action and resistance studies in . Antimicrobial Agents and Chemotherapy. PMID 30783004 DOI: 10.1128/Aac.02381-18  0.444
2018 Fernandez-Prada C, Sharma M, Plourde M, Bresson E, Roy G, Leprohon P, Ouellette M. High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms. International Journal For Parasitology. Drugs and Drug Resistance. 8: 165-173. PMID 29602064 DOI: 10.1016/J.Ijpddr.2018.03.004  0.534
2018 Gingras H, Dridi B, Leprohon P, Ouellette M. Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli. Microbial Genomics. PMID 29319470 DOI: 10.1099/mgen.0.000148  0.363
2017 Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, Pulcini C, Kahlmeter G, Kluytmans J, Carmeli Y, Ouellette M, Outterson K, Patel J, Cavaleri M, Cox EM, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. The Lancet. Infectious Diseases. PMID 29276051 DOI: 10.1016/S1473-3099(17)30753-3  0.429
2017 El Khoury JY, Boucher N, Bergeron MG, Leprohon P, Ouellette M. Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae. Scientific Reports. 7: 14587. PMID 29109543 DOI: 10.1038/S41598-017-15035-Y  0.461
2016 Fernandez-Prada C, Vincent IM, Brotherton MC, Roberts M, Roy G, Rivas L, Leprohon P, Smith TK, Ouellette M. Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms. Plos Neglected Tropical Diseases. 10: e0005171. PMID 27911896 DOI: 10.1371/Journal.Pntd.0005171  0.444
2016 Maheux AF, Sellam A, Piché Y, Boissinot M, Pelletier R, Boudreau DK, Picard FJ, Trépanier H, Boily MJ, Ouellette M, Roy PH, Bergeron MG. Use of phylogenetical analysis to predict susceptibility of pathogenic Candida spp. to antifungal drugs. Journal of Microbiological Methods. PMID 27713018 DOI: 10.1016/J.Mimet.2016.09.020  0.36
2016 Laffitte MN, Leprohon P, Papadopoulou B, Ouellette M. Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance. F1000research. 5: 2350. PMID 27703673 DOI: 10.12688/F1000Research.9218.1  0.364
2016 Laffitte MN, Leprohon P, Légaré D, Ouellette M. Deep-sequencing revealing mutation dynamics in the miltefosine transporter gene in Leishmania infantum selected for miltefosine resistance. Parasitology Research. PMID 27457482 DOI: 10.1007/S00436-016-5195-Y  0.43
2016 Laffitte MN, Leprohon P, Hainse M, Légaré D, Masson JY, Ouellette M. Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism. Plos Genetics. 12: e1006117. PMID 27314941 DOI: 10.1371/Journal.Pgen.1006117  0.339
2016 Gazanion É, Fernández-Prada C, Papadopoulou B, Leprohon P, Ouellette M. Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania. Proceedings of the National Academy of Sciences of the United States of America. PMID 27162331 DOI: 10.1073/Pnas.1520693113  0.512
2015 Vincent IM, Racine G, Légaré D, Ouellette M. Mitochondrial Proteomics of Antimony and Miltefosine Resistant Leishmania infantum. Proteomes. 3: 328-346. PMID 28248274 DOI: 10.3390/Proteomes3040328  0.439
2015 Roy G, Ouellette M. Inactivation of the cytosolic and mitochondrial serine hydroxymethyl transferase genes in Leishmania major. Molecular and Biochemical Parasitology. 204: 106-10. PMID 26868981 DOI: 10.1016/J.Molbiopara.2016.02.003  0.361
2015 Leprohon P, Gingras H, Ouennane S, Moineau S, Ouellette M. A genomic approach to understand interactions between Streptococcus pneumoniae and its bacteriophages. Bmc Genomics. 16: 972. PMID 26582495 DOI: 10.1186/S12864-015-2134-8  0.398
2015 Raymond F, Ouameur AA, Déraspe M, Iqbal N, Gingras H, Dridi B, Leprohon P, Plante PL, Giroux R, Bérubé È, Frenette J, Boudreau DK, Simard JL, Chabot I, Domingo MC, ... ... Ouellette M, et al. The initial state of the human gut microbiome determines its reshaping by antibiotics. The Isme Journal. PMID 26359913 DOI: 10.1038/Ismej.2015.148  0.371
2015 Plourde M, Ubeda JM, Mandal G, do Monte-Neto RL, Mukhopadhyay R, Ouellette M. Generation of an aquaglyceroporin AQP1 null mutant in Leishmania major. Molecular and Biochemical Parasitology. PMID 26222914 DOI: 10.1016/J.Molbiopara.2015.07.003  0.459
2015 Lupien A, Gingras H, Leprohon P, Ouellette M. Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA. The Journal of Antimicrobial Chemotherapy. 70: 2973-80. PMID 26183184 DOI: 10.1093/Jac/Dkv211  0.452
2015 Dridi B, Lupien A, Bergeron MG, Leprohon P, Ouellette M. Differences in antibiotic-induced oxidative stress responses between laboratory and clinical isolates of Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy. 59: 5420-6. PMID 26100702 DOI: 10.1128/Aac.00316-15  0.376
2015 Leprohon P, Fernandez-Prada C, Gazanion É, Monte-Neto R, Ouellette M. Drug resistance analysis by next generation sequencing in Leishmania. International Journal For Parasitology. Drugs and Drug Resistance. 5: 26-35. PMID 25941624 DOI: 10.1016/J.Ijpddr.2014.09.005  0.502
2015 Lupien A, Gingras H, Bergeron MG, Leprohon P, Ouellette M. Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing. The Journal of Antimicrobial Chemotherapy. 70: 1946-59. PMID 25862682 DOI: 10.1093/Jac/Dkv060  0.396
2015 Genois MM, Plourde M, Éthier C, Roy G, Poirier GG, Ouellette M, Masson JY. Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum. Nucleic Acids Research. 43: 2701-15. PMID 25712090 DOI: 10.1093/Nar/Gkv118  0.451
2015 Monte-Neto R, Laffitte MC, Leprohon P, Reis P, Frézard F, Ouellette M. Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis. Plos Neglected Tropical Diseases. 9: e0003476. PMID 25679388 DOI: 10.1371/Journal.Pntd.0003476  0.481
2014 Laffitte MC, Genois MM, Mukherjee A, Légaré D, Masson JY, Ouellette M. Formation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nuclease. Plos Genetics. 10: e1004805. PMID 25474106 DOI: 10.1371/Journal.Pgen.1004805  0.388
2014 Brotherton MC, Bourassa S, Légaré D, Poirier GG, Droit A, Ouellette M. Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum. International Journal For Parasitology. Drugs and Drug Resistance. 4: 126-32. PMID 25057462 DOI: 10.1016/J.Ijpddr.2014.05.002  0.479
2014 Ubeda JM, Raymond F, Mukherjee A, Plourde M, Gingras H, Roy G, Lapointe A, Leprohon P, Papadopoulou B, Corbeil J, Ouellette M. Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania. Plos Biology. 12: e1001868. PMID 24844805 DOI: 10.1371/Journal.Pbio.1001868  0.319
2014 Genois MM, Paquet ER, Laffitte MC, Maity R, Rodrigue A, Ouellette M, Masson JY. DNA repair pathways in trypanosomatids: from DNA repair to drug resistance. Microbiology and Molecular Biology Reviews : Mmbr. 78: 40-73. PMID 24600040 DOI: 10.1128/Mmbr.00045-13  0.34
2014 Vincent IM, Weidt S, Rivas L, Burgess K, Smith TK, Ouellette M. Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism. International Journal For Parasitology. Drugs and Drug Resistance. 4: 20-7. PMID 24596665 DOI: 10.1016/J.Ijpddr.2013.11.002  0.353
2014 Fani F, Leprohon P, Zhanel GG, Bergeron MG, Ouellette M. Genomic analyses of DNA transformation and penicillin resistance in Streptococcus pneumoniae clinical isolates. Antimicrobial Agents and Chemotherapy. 58: 1397-403. PMID 24342643 DOI: 10.1128/Aac.01311-13  0.429
2014 Moreira W, Légaré D, Racine G, Roy G, Ouellette M. Proteomic analysis of metacyclogenesis in Leishmania infantum wild-type and PTR1 null mutant Eupa Open Proteomics. 4: 171-183. DOI: 10.1016/J.Euprot.2014.07.003  0.318
2013 Brotherton MC, Bourassa S, Leprohon P, Légaré D, Poirier GG, Droit A, Ouellette M. Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant. Plos One. 8: e81899. PMID 24312377 DOI: 10.1371/Journal.Pone.0081899  0.471
2013 Ritt JF, Raymond F, Leprohon P, Légaré D, Corbeil J, Ouellette M. Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum. Plos Neglected Tropical Diseases. 7: e2564. PMID 24278495 DOI: 10.1371/Journal.Pntd.0002564  0.479
2013 Lupien A, Billal DS, Fani F, Soualhine H, Zhanel GG, Leprohon P, Ouellette M. Genomic characterization of ciprofloxacin resistance in a laboratory-derived mutant and a clinical isolate of Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy. 57: 4911-9. PMID 23877698 DOI: 10.1128/Aac.00418-13  0.481
2013 Kumar P, Lodge R, Raymond F, Ritt JF, Jalaguier P, Corbeil J, Ouellette M, Tremblay MJ. Gene expression modulation and the molecular mechanisms involved in Nelfinavir resistance in Leishmania donovani axenic amastigotes. Molecular Microbiology. 89: 565-82. PMID 23782314 DOI: 10.1111/Mmi.12298  0.564
2013 Fani F, Brotherton MC, Leprohon P, Ouellette M. Genomic analysis and reconstruction of cefotaxime resistance in Streptococcus pneumoniae. The Journal of Antimicrobial Chemotherapy. 68: 1718-27. PMID 23608923 DOI: 10.1093/Jac/Dkt113  0.39
2013 Santarém N, Racine G, Silvestre R, Cordeiro-da-Silva A, Ouellette M. Exoproteome dynamics in Leishmania infantum. Journal of Proteomics. 84: 106-18. PMID 23558030 DOI: 10.1016/J.Jprot.2013.03.012  0.303
2013 Mukherjee A, Boisvert S, Monte-Neto RL, Coelho AC, Raymond F, Mukhopadhyay R, Corbeil J, Ouellette M. Telomeric gene deletion and intrachromosomal amplification in antimony-resistant Leishmania. Molecular Microbiology. 88: 189-202. PMID 23421749 DOI: 10.1111/Mmi.12178  0.517
2012 Coelho AC, Leprohon P, Ouellette M. Generation of Leishmania hybrids by whole genomic DNA transformation. Plos Neglected Tropical Diseases. 6: e1817. PMID 23029579 DOI: 10.1371/Journal.Pntd.0001817  0.423
2012 Genois MM, Mukherjee A, Ubeda JM, Buisson R, Paquet E, Roy G, Plourde M, Coulombe Y, Ouellette M, Masson JY. Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum. Nucleic Acids Research. 40: 6570-84. PMID 22505581 DOI: 10.1093/Nar/Gks306  0.33
2012 Walker J, Gongora R, Vasquez JJ, Drummelsmith J, Burchmore R, Roy G, Ouellette M, Gomez MA, Saravia NG. Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysis. Molecular and Biochemical Parasitology. 183: 166-76. PMID 22449941 DOI: 10.1016/J.Molbiopara.2012.03.002  0.52
2012 Coelho AC, Boisvert S, Mukherjee A, Leprohon P, Corbeil J, Ouellette M. Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing. Plos Neglected Tropical Diseases. 6: e1512. PMID 22348164 DOI: 10.1371/Journal.Pntd.0001512  0.461
2012 Plourde M, Coelho A, Keynan Y, Larios OE, Ndao M, Ruest A, Roy G, Rubinstein E, Ouellette M. Genetic polymorphisms and drug susceptibility in four isolates of Leishmania tropica obtained from Canadian soldiers returning from Afghanistan. Plos Neglected Tropical Diseases. 6: e1463. PMID 22272366 DOI: 10.1371/Journal.Pntd.0001463  0.308
2011 Fani F, Leprohon P, Légaré D, Ouellette M. Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease. Genome Biology. 12: R115. PMID 22108223 DOI: 10.1186/Gb-2011-12-11-R115  0.466
2011 Billal DS, Feng J, Leprohon P, Légaré D, Ouellette M. Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations. Bmc Genomics. 12: 512. PMID 22004526 DOI: 10.1186/1471-2164-12-512  0.411
2011 Leprohon P, Légaré D, Ouellette M. ABC transporters involved in drug resistance in human parasites. Essays in Biochemistry. 50: 121-44. PMID 21967055 DOI: 10.1042/Bse0500121  0.455
2011 Moreira W, Leprohon P, Ouellette M. Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania Cell Death and Disease. 2. PMID 21881603 DOI: 10.1038/Cddis.2011.83  0.468
2011 Feng J, Billal DS, Lupien A, Racine G, Winstall E, Légaré D, Leprohon P, Ouellette M. Proteomic and transcriptomic analysis of linezolid resistance in Streptococcus pneumoniae. Journal of Proteome Research. 10: 4439-52. PMID 21875071 DOI: 10.1021/Pr200221S  0.528
2011 do Monte-Neto RL, Coelho AC, Raymond F, Légaré D, Corbeil J, Melo MN, Frézard F, Ouellette M. Gene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensis. Plos Neglected Tropical Diseases. 5: e1167. PMID 21629719 DOI: 10.1371/Journal.Pntd.0001167  0.496
2011 Sabri M, Häuser R, Ouellette M, Liu J, Dehbi M, Moeck G, García E, Titz B, Uetz P, Moineau S. Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1. Journal of Bacteriology. 193: 551-62. PMID 21097633 DOI: 10.1128/Jb.01117-10  0.306
2010 Dridi L, Ahmed Ouameur A, Ouellette M. High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family. The Journal of Biological Chemistry. 285: 19767-75. PMID 20406813 DOI: 10.1074/Jbc.M110.114520  0.519
2010 Dridi L, Haimeur A, Ouellette M. Structure-function analysis of the highly conserved charged residues of the membrane protein FT1, the main folic acid transporter of the protozoan parasite Leishmania. Biochemical Pharmacology. 79: 30-8. PMID 19660435 DOI: 10.1016/J.Bcp.2009.07.019  0.339
2009 Ouellette M, Papadopoulou B. Coordinated gene expression by post-transcriptional regulons in African trypanosomes. Journal of Biology. 8: 100. PMID 20017896 DOI: 10.1186/Jbiol203  0.33
2009 Mukherjee A, Roy G, Guimond C, Ouellette M. The gamma-glutamylcysteine synthetase gene of Leishmania is essential and involved in response to oxidants. Molecular Microbiology. 74: 914-27. PMID 19818018 DOI: 10.1111/J.1365-2958.2009.06907.X  0.387
2009 El Fadili K, Drummelsmith J, Roy G, Jardim A, Ouellette M. Down regulation of KMP-11 in Leishmania infantum axenic antimony resistant amastigotes as revealed by a proteomic screen. Experimental Parasitology. 123: 51-7. PMID 19500579 DOI: 10.1016/J.Exppara.2009.05.013  0.503
2009 Rochette A, Raymond F, Corbeil J, Ouellette M, Papadopoulou B. Whole-genome comparative RNA expression profiling of axenic and intracellular amastigote forms of Leishmania infantum. Molecular and Biochemical Parasitology. 165: 32-47. PMID 19393160 DOI: 10.1016/J.Molbiopara.2008.12.012  0.394
2009 Feng J, Lupien A, Gingras H, Wasserscheid J, Dewar K, Légaré D, Ouellette M. Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Research. 19: 1214-23. PMID 19351617 DOI: 10.1101/Gr.089342.108  0.485
2009 Leprohon P, Légaré D, Ouellette M. Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials. Antimicrobial Agents and Chemotherapy. 53: 2646-9. PMID 19307364 DOI: 10.1128/Aac.01474-08  0.422
2009 Leprohon P, Légaré D, Raymond F, Madore E, Hardiman G, Corbeil J, Ouellette M. Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum. Nucleic Acids Research. 37: 1387-99. PMID 19129236 DOI: 10.1093/nar/gkn1069  0.382
2009 Moreira W, Leblanc E, Ouellette M. The role of reduced pterins in resistance to reactive oxygen and nitrogen intermediates in the protozoan parasite Leishmania. Free Radical Biology & Medicine. 46: 367-75. PMID 19022374 DOI: 10.1016/J.Freeradbiomed.2008.10.034  0.363
2008 Keynan Y, Larios OE, Wiseman MC, Plourde M, Ouellette M, Rubinstein E. Use of oral miltefosine for cutaneous leishmaniasis in Canadian soldiers returning from Afghanistan. The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie MéDicale / Ammi Canada. 19: 394-6. PMID 19436567 DOI: 10.1155/2008/802710  0.31
2008 Trudel N, Garg R, Messier N, Sundar S, Ouellette M, Tremblay MJ. Intracellular survival of Leishmania species that cause visceral leishmaniasis is significantly reduced by HIV-1 protease inhibitors. The Journal of Infectious Diseases. 198: 1292-9. PMID 18816190 DOI: 10.1086/592280  0.347
2008 Ouameur AA, Girard I, Légaré D, Ouellette M. Functional analysis and complex gene rearrangements of the folate/biopterin transporter (FBT) gene family in the protozoan parasite Leishmania. Molecular and Biochemical Parasitology. 162: 155-64. PMID 18796316 DOI: 10.1016/J.Molbiopara.2008.08.007  0.503
2008 Isabel S, Leblanc E, Boissinot M, Boudreau DK, Grondin M, Picard FJ, Martel EA, Parham NJ, Chain PS, Bader DE, Mulvey MR, Bryden L, Roy PH, Ouellette M, Bergeron MG. Divergence among genes encoding the elongation factor Tu of Yersinia Species. Journal of Bacteriology. 190: 7548-58. PMID 18790860 DOI: 10.1128/Jb.01067-08  0.362
2008 Ubeda JM, Légaré D, Raymond F, Ouameur AA, Boisvert S, Rigault P, Corbeil J, Tremblay MJ, Olivier M, Papadopoulou B, Ouellette M. Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy. Genome Biology. 9: R115. PMID 18638379 DOI: 10.1186/Gb-2008-9-7-R115  0.539
2008 Rochette A, Raymond F, Ubeda JM, Smith M, Messier N, Boisvert S, Rigault P, Corbeil J, Ouellette M, Papadopoulou B. Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species. Bmc Genomics. 9: 255. PMID 18510761 DOI: 10.1186/1471-2164-9-255  0.369
2008 Genest PA, Haimeur A, Légaré D, Sereno D, Roy G, Messier N, Papadopoulou B, Ouellette M. A protein of the leucine-rich repeats (LRRs) superfamily is implicated in antimony resistance in Leishmania infantum amastigotes. Molecular and Biochemical Parasitology. 158: 95-9. PMID 18164495 DOI: 10.1016/J.Molbiopara.2007.11.008  0.502
2008 El Fadili K, Imbeault M, Messier N, Roy G, Gourbal B, Bergeron M, Tremblay MJ, Légaré D, Ouellette M. Modulation of gene expression in human macrophages treated with the anti-leishmania pentavalent antimonial drug sodium stibogluconate. Antimicrobial Agents and Chemotherapy. 52: 526-33. PMID 18070969 DOI: 10.1128/Aac.01183-07  0.415
2007 Drummelsmith J, Winstall E, Bergeron MG, Poirier GG, Ouellette M. Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains. Journal of Proteome Research. 6: 4690-702. PMID 17997515 DOI: 10.1021/Pr070521M  0.396
2007 Figarella K, Uzcategui NL, Zhou Y, LeFurgey A, Ouellette M, Bhattacharjee H, Mukhopadhyay R. Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis. Molecular Microbiology. 65: 1006-17. PMID 17640270 DOI: 10.1111/j.1365-2958.2007.05845.x  0.34
2007 Hadighi R, Boucher P, Khamesipour A, Meamar AR, Roy G, Ouellette M, Mohebali M. Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs Parasitology Research. 101: 1319-1322. PMID 17610079 DOI: 10.1007/S00436-007-0638-0  0.465
2007 Coelho AC, Messier N, Ouellette M, Cotrim PC. Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes. Antimicrobial Agents and Chemotherapy. 51: 3030-2. PMID 17452480 DOI: 10.1128/Aac.00404-07  0.479
2007 Mukherjee A, Padmanabhan PK, Singh S, Roy G, Girard I, Chatterjee M, Ouellette M, Madhubala R. Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani. The Journal of Antimicrobial Chemotherapy. 59: 204-11. PMID 17213267 DOI: 10.1093/Jac/Dkl494  0.462
2007 Vergnes B, Gourbal B, Girard I, Sundar S, Drummelsmith J, Ouellette M. A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death. Molecular & Cellular Proteomics : McP. 6: 88-101. PMID 17050524 DOI: 10.1074/Mcp.M600319-Mcp200  0.489
2006 Leprohon P, Légaré D, Girard I, Papadopoulou B, Ouellette M. Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites. Eukaryotic Cell. 5: 1713-25. PMID 17030997 DOI: 10.1128/Ec.00152-06  0.46
2006 Gagnon D, Foucher A, Girard I, Ouellette M. Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania. Molecular and Biochemical Parasitology. 150: 63-71. PMID 16876889 DOI: 10.1016/J.Molbiopara.2006.06.009  0.44
2006 McNicoll F, Drummelsmith J, Müller M, Madore E, Boilard N, Ouellette M, Papadopoulou B. A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum. Proteomics. 6: 3567-81. PMID 16705753 DOI: 10.1002/Pmic.200500853  0.329
2006 Rojas R, Valderrama L, Valderrama M, Varona MX, Ouellette M, Saravia NG. Resistance to antimony and treatment failure in human Leishmania (Viannia) infection. The Journal of Infectious Diseases. 193: 1375-83. PMID 16619185 DOI: 10.1086/503371  0.393
2006 Hadighi R, Mohebali M, Boucher P, Hajjaran H, Khamesipour A, Ouellette M. Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites. Plos Medicine. 3: e162. PMID 16605301 DOI: 10.1371/journal.pmed.0030162  0.332
2006 Walker J, Vasquez JJ, Gomez MA, Drummelsmith J, Burchmore R, Girard I, Ouellette M. Identification of developmentally-regulated proteins in Leishmania panamensis by proteome profiling of promastigotes and axenic amastigotes. Molecular and Biochemical Parasitology. 147: 64-73. PMID 16530278 DOI: 10.1016/J.Molbiopara.2006.01.008  0.345
2006 Carter KC, Hutchison S, Henriquez FL, Légaré D, Ouellette M, Roberts CW, Mullen AB. Resistance of Leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase. Antimicrobial Agents and Chemotherapy. 50: 88-95. PMID 16377672 DOI: 10.1128/Aac.50.1.88-95.2006  0.401
2005 Soualhine H, Brochu V, Ménard F, Papadopoulou B, Weiss K, Bergeron MG, Légaré D, Drummelsmith J, Ouellette M. A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter. Molecular Microbiology. 58: 1430-40. PMID 16313627 DOI: 10.1111/J.1365-2958.2005.04914.X  0.532
2005 Paradis S, Boissinot M, Paquette N, Bélanger SD, Martel EA, Boudreau DK, Picard FJ, Ouellette M, Roy PH, Bergeron MG. Phylogeny of the Enterobacteriaceae based on genes encoding elongation factor Tu and F-ATPase beta-subunit. International Journal of Systematic and Evolutionary Microbiology. 55: 2013-25. PMID 16166704 DOI: 10.1099/Ijs.0.63539-0  0.34
2005 Marquis N, Gourbal B, Rosen BP, Mukhopadhyay R, Ouellette M. Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania. Molecular Microbiology. 57: 1690-9. PMID 16135234 DOI: 10.1111/J.1365-2958.2005.04782.X  0.495
2005 El Fadili K, Messier N, Leprohon P, Roy G, Guimond C, Trudel N, Saravia NG, Papadopoulou B, Légaré D, Ouellette M. Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes. Antimicrobial Agents and Chemotherapy. 49: 1988-93. PMID 15855523 DOI: 10.1128/Aac.49.5.1988-1993.2005  0.579
2004 Brochu C, Haimeur A, Ouellette M. The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite leishmania. Cell Stress & Chaperones. 9: 294-303. PMID 15544167 DOI: 10.1379/Csc-15R1.1  0.743
2004 Richard D, Leprohon P, Drummelsmith J, Ouellette M. Growth phase regulation of the main folate transporter of Leishmania infantum and its role in methotrexate resistance. The Journal of Biological Chemistry. 279: 54494-501. PMID 15466466 DOI: 10.1074/Jbc.M409264200  0.732
2004 Picard FJ, Ke D, Boudreau DK, Boissinot M, Huletsky A, Richard D, Ouellette M, Roy PH, Bergeron MG. Use of tuf sequences for genus-specific PCR detection and phylogenetic analysis of 28 streptococcal species. Journal of Clinical Microbiology. 42: 3686-95. PMID 15297518 DOI: 10.1128/Jcm.42.8.3686-3695.2004  0.677
2004 Zhou Y, Messier N, Ouellette M, Rosen BP, Mukhopadhyay R. Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam. The Journal of Biological Chemistry. 279: 37445-51. PMID 15220340 DOI: 10.1074/Jbc.M404383200  0.303
2004 Drummelsmith J, Girard I, Trudel N, Ouellette M. Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance. The Journal of Biological Chemistry. 279: 33273-80. PMID 15190060 DOI: 10.1074/Jbc.M405183200  0.531
2004 Gourbal B, Sonuc N, Bhattacharjee H, Legare D, Sundar S, Ouellette M, Rosen BP, Mukhopadhyay R. Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin. The Journal of Biological Chemistry. 279: 31010-7. PMID 15138256 DOI: 10.1074/Jbc.M403959200  0.413
2004 El Fadili A, Kündig C, Roy G, Ouellette M. Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate. The Journal of Biological Chemistry. 279: 18575-82. PMID 14981076 DOI: 10.1074/Jbc.M400652200  0.793
2003 Ouellette M, Olivier M, Sato S, Papadopoulou B. [Studies on the parasite Leishmania in the post-genomic era]. MéDecine Sciences : M/S. 19: 900-9. PMID 14612998 DOI: 10.1051/Medsci/20031910900  0.405
2003 Guimond C, Trudel N, Brochu C, Marquis N, El Fadili A, Peytavi R, Briand G, Richard D, Messier N, Papadopoulou B, Corbeil J, Bergeron MG, Légaré D, Ouellette M. Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays. Nucleic Acids Research. 31: 5886-96. PMID 14530437 DOI: 10.1093/Nar/Gkg806  0.76
2003 Pérez-Victoria FJ, Gamarro F, Ouellette M, Castanys S. Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance. The Journal of Biological Chemistry. 278: 49965-71. PMID 14514670 DOI: 10.1074/jbc.M308352200  0.357
2003 Brochu C, Wang J, Roy G, Messier N, Wang XY, Saravia NG, Ouellette M. Antimony uptake systems in the protozoan parasite Leishmania and accumulation differences in antimony-resistant parasites. Antimicrobial Agents and Chemotherapy. 47: 3073-9. PMID 14506011 DOI: 10.1128/Aac.47.10.3073-3079.2003  0.755
2003 El-Fadili A, Richard D, Kündig C, Ouellette M. Effect of polyglutamylation of methotrexate on its accumulation and the development of resistance in the protozoan parasite Leishmania. Biochemical Pharmacology. 66: 999-1008. PMID 12963486 DOI: 10.1016/S0006-2952(03)00417-9  0.773
2003 Lapierre P, Huletsky A, Fortin V, Picard FJ, Roy PH, Ouellette M, Bergeron MG. Real-time PCR assay for detection of fluoroquinolone resistance associated with grlA mutations in Staphylococcus aureus. Journal of Clinical Microbiology. 41: 3246-51. PMID 12843071 DOI: 10.1128/Jcm.41.7.3246-3251.2003  0.389
2003 Ferreira Cdos S, Martins PS, Demicheli C, Brochu C, Ouellette M, Frézard F. Thiol-induced reduction of antimony(V) into antimony(III): a comparative study with trypanothione, cysteinyl-glycine, cysteine and glutathione. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 16: 441-6. PMID 12680707 DOI: 10.1023/A:1022823605068  0.673
2003 Drummelsmith J, Brochu V, Girard I, Messier N, Ouellette M. Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms. Molecular & Cellular Proteomics : McP. 2: 146-55. PMID 12644573 DOI: 10.1074/Mcp.M200085-Mcp200  0.478
2002 El Fadili A, Kündig C, Ouellette M. Characterization of the folylpolyglutamate synthetase gene and polyglutamylation of folates in the protozoan parasite Leishmania. Molecular and Biochemical Parasitology. 124: 63-71. PMID 12387851 DOI: 10.1016/S0166-6851(02)00163-9  0.754
2002 El Fakhry Y, Ouellette M, Papadopoulou B. A proteomic approach to identify developmentally regulated proteins in Leishmania infantum. Proteomics. 2: 1007-17. PMID 12203896 DOI: 10.1002/1615-9861(200208)2:8<1007::Aid-Prot1007>3.0.Co;2-G  0.34
2002 Richard D, Kündig C, Ouellette M. A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells. The Journal of Biological Chemistry. 277: 29460-7. PMID 12023977 DOI: 10.1074/Jbc.M204796200  0.749
2002 Ouellette M, Drummelsmith J, El-Fadili A, Kündig C, Richard D, Roy G. Pterin transport and metabolism in Leishmania and related trypanosomatid parasites. International Journal For Parasitology. 32: 385-98. PMID 11849635 DOI: 10.1016/S0020-7519(01)00346-0  0.707
2002 Papadopoulou B, Roy G, Breton M, Kündig C, Dumas C, Fillion I, Singh AK, Olivier M, Ouellette M. Reduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination. Infection and Immunity. 70: 62-8. PMID 11748164 DOI: 10.1128/Iai.70.1.62-68.2002  0.373
2001 Singh AK, Papadopoulou B, Ouellette M. Gene amplification in amphotericin B-resistant Leishmania tarentolae Experimental Parasitology. 99: 141-147. PMID 11846524 DOI: 10.1006/Expr.2001.4663  0.532
2001 Légaré D, Cayer S, Singh AK, Richard D, Papadopoulou B, Ouellette M. ABC proteins of Leishmania. Journal of Bioenergetics and Biomembranes. 33: 469-74. PMID 11804188 DOI: 10.1023/A:1012870904097  0.754
2001 Ouellette M. Biochemical and molecular mechanisms of drug resistance in parasites Tropical Medicine and International Health. 6: 874-882. PMID 11703841 DOI: 10.1046/J.1365-3156.2001.00777.X  0.499
2001 Ouellette M, Légaré D, Papadopoulou B. Multidrug resistance and ABC transporters in parasitic protozoa Journal of Molecular Microbiology and Biotechnology. 3: 201-206. PMID 11321574  0.465
2001 Roy G, Kündig C, Olivier M, Papadopoulou B, Ouellette M. Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin Experimental Parasitology. 97: 161-168. PMID 11312578 DOI: 10.1006/Expr.2001.4595  0.321
2001 Légaré D, Richard D, Mukhopadhyay R, Stierhof YD, Rosen BP, Haimeur A, Papadopoulou B, Ouellette M. The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase. The Journal of Biological Chemistry. 276: 26301-7. PMID 11306588 DOI: 10.1074/Jbc.M102351200  0.701
2001 Sereno D, Roy G, Loup Lemesre J, Papadopoulou B, Ouellette M. DNA transformation of Leishmania infantum axenic amastigotes and their use in drug screening Antimicrobial Agents and Chemotherapy. 45: 1168-1173. PMID 11257031 DOI: 10.1128/Aac.45.4.1168-1173.2001  0.361
2000 Ke D, Boissinot M, Huletsky A, Picard FJ, Frenette J, Ouellette M, Roy PH, Bergeron MG. Evidence for horizontal gene transfer in evolution of elongation factor Tu in enterococci. Journal of Bacteriology. 182: 6913-20. PMID 11092850 DOI: 10.1128/Jb.182.24.6913-6920.2000  0.399
2000 Roy G, Dumas C, Sereno D, Wu Y, Singh AK, Tremblay MJ, Ouellette M, Olivier M, Papadopoulou B. Episomal and stable expression of the luciferase reporter gene for quantifying Leishmania spp. infections in macrophages and in animal models Molecular and Biochemical Parasitology. 110: 195-206. PMID 11071276 DOI: 10.1016/S0166-6851(00)00270-X  0.384
2000 Martineau F, Picard FJ, Grenier L, Roy PH, Ouellette M, Bergeron MG. Multiplex PCR assays for the detection of clinically relevant antibiotic resistance genes in staphylococci isolated from patients infected after cardiac surgery. The ESPRIT Trial. The Journal of Antimicrobial Chemotherapy. 46: 527-34. PMID 11020248 DOI: 10.1093/Jac/46.4.527  0.484
2000 Lansac N, Picard FJ, Ménard C, Boissinot M, Ouellette M, Roy PH, Bergeron MG. Novel genus-specific PCR-based assays for rapid identification of Neisseria species and Neisseria meningitidis. European Journal of Clinical Microbiology & Infectious Diseases. 19: 443-451. PMID 10947220 DOI: 10.1007/S100960000290  0.313
2000 Haimeur A, Brochu C, Genest P, Papadopoulou B, Ouellette M. Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae. Molecular and Biochemical Parasitology. 108: 131-5. PMID 10802326 DOI: 10.1016/S0166-6851(00)00187-0  0.783
2000 Martineau F, Picard FJ, Lansac N, Ménard C, Roy PH, Ouellette M, Bergeron MG. Correlation between the resistance genotype determined by multiplex PCR assays and the antibiotic susceptibility patterns of Staphylococcus aureus and Staphylococcus epidermidis. Antimicrobial Agents and Chemotherapy. 44: 231-8. PMID 10639342 DOI: 10.1128/Aac.44.2.231-238.2000  0.485
1999 Dey S, Ouellette M, Rosen BP. ATP-binding cassette transporters: from multidrug resistance to genetic disease, Gosau, Austria, 20-27 February 1999. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 2: 130-133. PMID 11504481 DOI: 10.1054/Drup.1999.0072  0.388
1999 Haimeur A, Guimond C, Pilote S, Mukhopadhyay R, Rosen BP, Poulin R, Ouellette M. Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite-resistant Leishmania Molecular Microbiology. 34: 726-735. PMID 10564512 DOI: 10.1046/J.1365-2958.1999.01634.X  0.529
1999 Kündig C, Leblanc E, Papadopoulou B, Ouellette M. Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae Nucleic Acids Research. 27: 3653-3659. PMID 10471733 DOI: 10.1093/Nar/27.18.3653  0.511
1999 Kündig C, Haimeur A, Légaré D, Papadopoulou B, Ouellette M. Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae Embo Journal. 18: 2342-2351. PMID 10228149 DOI: 10.1093/Emboj/18.9.2342  0.493
1998 Ouellette M, Légaré D, Haimeur A, Grondin K, Roy G, Brochu C, Papadopoulou B. ABC transporters in Leishmania and their role in drug resistance. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 1: 43-8. PMID 17092795 DOI: 10.1016/S1368-7646(98)80213-6  0.773
1998 Ouellette M, Leblanc E, Kündig C, Papadopoulou B. Antifolate resistance mechanisms from bacteria to cancer cells with emphasis on parasites Advances in Experimental Medicine and Biology. 456: 99-113. PMID 10549365 DOI: 10.1007/978-1-4615-4897-3_6  0.318
1998 Bergeron MG, Ouellette M. Preventing Antibiotic Resistance Using Rapid DNA-Based Diagnostic Tests Infection Control and Hospital Epidemiology. 19: 560-564. PMID 9758055 DOI: 10.1086/647873  0.363
1998 Ouellette M, Haimeur A, Grondin K, Légaré D, Papadopoulou B. Amplification of ABC transporter gene pgpA and of other heavy metal resistance genes in Leishmania tarentolae and their study by gene transfection and gene disruption Methods in Enzymology. 292: 182-193. PMID 9711554 DOI: 10.1016/S0076-6879(98)92015-8  0.542
1998 Bergeron MG, Ouellette M. Preventing antibiotic resistance through rapid genotypic identification of bacteria and of their antibiotic resistance genes in the clinical microbiology laboratory Journal of Clinical Microbiology. 36: 2169-2172. PMID 9665984 DOI: 10.1128/Jcm.36.8.2169-2172.1998  0.427
1998 Haimeur A, Ouellette M. Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate Antimicrobial Agents and Chemotherapy. 42: 1689-1694. PMID 9661005 DOI: 10.1128/Aac.42.7.1689  0.541
1998 Grondin K, Kündig C, Roy G, Ouellette M. Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolae Nucleic Acids Research. 26: 3372-3378. PMID 9649621 DOI: 10.1093/Nar/26.14.3370  0.482
1998 Martineau F, Picard FJ, Roy PH, Ouellette M, Bergeron MG. Species-specific and ubiquitous-DNA-based assays for rapid identification of Staphylococcus aureus. Journal of Clinical Microbiology. 36: 618-23. PMID 9508283 DOI: 10.1128/Jcm.36.3.618-623.1998  0.342
1998 Leblanc E, Papadopoulou B, Bernatchez C, Ouellette M. Residues involved in co-factor and substrate binding of the short-chain dehydrogenase/reductase PTR1 producing methotrexate resistance in Leishmania European Journal of Biochemistry. 251: 768-774. PMID 9490050 DOI: 10.1046/J.1432-1327.1998.2510768.X  0.328
1998 Papadopoulou B, Kündig C, Singh A, Ouellette M. Drug resistance in Leishmania: similarities and differences to other organisms Drug Resistance Updates. 1: 266-278. DOI: 10.1016/S1368-7646(98)80007-1  0.487
1997 Légaré D, Papadopoulou B, Roy G, Mukhopadhyay R, Haimeur A, Dey S, Grondin K, Brochu C, Rosen BP, Ouellette M. Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania. Experimental Parasitology. 87: 275-82. PMID 9371094 DOI: 10.1006/Expr.1997.4222  0.767
1997 Grondin K, Haimeur A, Mukhopadhyay R, Rosen BP, Ouellette M. Co-amplification of the γ-glutamylcysteine synthetase gene gsh1 and of the ABC transporter gene pgpA in arsenite-resistant Leishmania tarentolae Embo Journal. 16: 3057-3065. PMID 9214623 DOI: 10.1093/Emboj/16.11.3057  0.564
1997 Wang J, Leblanc E, Chang CF, Papadopoulou B, Bray T, Whiteley JM, Lin SX, Ouellette M. Pterin and folate reduction by the Leishmania tarentolae H locus short- chain dehydrogenase/reductase PTR1 Archives of Biochemistry and Biophysics. 342: 197-202. PMID 9186479 DOI: 10.1006/Abbi.1997.0126  0.32
1997 Muyombwe A, Olivier M, Ouellette M, Papadopoulou B. Selective killing of Leishmania amastigotes expressing a thymidine kinase suicide gene Experimental Parasitology. 85: 35-42. PMID 9024200 DOI: 10.1006/Expr.1996.4115  0.375
1997 Ouellette M, Kündig C. Microbial multidrug resistance International Journal of Antimicrobial Agents. 8: 179-187. DOI: 10.1016/S0924-8579(96)00370-6  0.531
1997 Ouellette M, Papadopoulou B, Olivier M. New molecular and cellular aspects of infection by Leishmania Medecine/Sciences. 13: 934-941.  0.344
1996 Mukhopadhyay R, Dey S, Xu N, Gage D, Lightbody J, Ouellette M, Rosen BP. Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania. Proceedings of the National Academy of Sciences of the United States of America. 93: 10383-7. PMID 8816809 DOI: 10.1073/Pnas.93.19.10383  0.392
1996 Papadopoulou B, Roy G, Dey S, Rosen BP, Olivier M, Ouellette M. Gene disruption of the p-glycoprotein related gene pgpA of leishmania tarentolae Biochemical and Biophysical Research Communications. 224: 772-778. PMID 8713121 DOI: 10.1006/Bbrc.1996.1098  0.515
1996 Dey S, Ouellette M, Lightbody J, Papadopoulou B, Rosen BP. An ATP-dependent as(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae Proceedings of the National Academy of Sciences of the United States of America. 93: 2192-2197. PMID 8700907 DOI: 10.1073/Pnas.93.5.2192  0.383
1996 Grondin K, Roy G, Ouellette M. Formation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolae Molecular and Cellular Biology. 16: 3587-3595. PMID 8668175 DOI: 10.1128/Mcb.16.7.3587  0.47
1995 Borst P, Ouellette M. New mechanisms of drug resistance in parasitic protozoa Annual Review of Microbiology. 49: 427-460. PMID 8561467 DOI: 10.1146/Annurev.Mi.49.100195.002235  0.467
1994 Papadopoulou B, Roy G, Ouellette M. Autonomous replication of bacterial DNA plasmid oligomers in Leishmania Molecular and Biochemical Parasitology. 65: 39-49. PMID 7935627 DOI: 10.1016/0166-6851(94)90113-9  0.448
1994 Gamarro F, Chiquero MJ, Amador MV, Légaré D, Ouellette M, Castanys S. P-glycoprotein overexpression in methotrexate-resistant Leishmania tropica. Biochemical Pharmacology. 47: 1939-47. PMID 7912069 DOI: 10.1016/0006-2952(94)90067-1  0.53
1994 Légaré D, Hettema E, Ouellette M. The P-glycoprotein-related gene family in Leishmania Molecular and Biochemical Parasitology. 68: 81-91. PMID 7891750 DOI: 10.1016/0166-6851(94)00156-1  0.5
1994 Ouellette M, Légaré D, Papadopoulou B. Microbial multidrug-resistance ABC transporters Trends in Microbiology. 2: 407-411. PMID 7850210 DOI: 10.1016/0966-842X(94)90620-3  0.526
1994 Dey S, Papadopoulou B, Haimeur A, Roy G, Grondin K, Dou D, Rosen BP, Ouellette M. High level arsenite resistance in Leishmania tarentolae is mediated by an active extrusion system Molecular and Biochemical Parasitology. 67: 49-57. PMID 7838183 DOI: 10.1016/0166-6851(94)90095-7  0.536
1993 Papadopoulou B, Roy G, Ouellette M. Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methortexate resistant lesihmania Nucleic Acids Research. 21: 4305-4312. PMID 8414986 DOI: 10.1093/Nar/21.18.4305  0.503
1993 Papadopoulou B, Ouellette M. Frequent amplification of a short chain dehydrogenase gene in methotrexate resistant Leishmania Advances in Experimental Medicine and Biology. 338: 559-562. PMID 8304180 DOI: 10.1007/978-1-4615-2960-6_114  0.519
1993 Grondin K, Papadopoulon B, Ouellette M. Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania Nucleic Acids Research. 21: 1895-1901. PMID 8098523 DOI: 10.1093/Nar/21.8.1895  0.435
1993 Ouellette M, Papadopoulou B. Mechanisms of drug resistance in Leishmania Parasitology Today. 9: 150-153. DOI: 10.1016/0169-4758(93)90135-3  0.334
1992 Papadopoulou B, Roy G, Ouellette M. A novel antifolate resistance gene on the amplified H circle of Leishmania Embo Journal. 11: 3601-3608. PMID 1396560 DOI: 10.1002/J.1460-2075.1992.Tb05444.X  0.398
1991 Ouellette M, Borst P. Drug resistance and P-glycoprotein gene amplification in the protozoan parasite Leishmania Research in Microbiology. 142: 737-746. PMID 1961984 DOI: 10.1016/0923-2508(91)90089-S  0.317
1990 Ouellette M, Fase-Fowler F, Borst P. The amplified H circle of methotrexate-resistant Leishmania tarentolae contains a novel P-glycoprotein gene Embo Journal. 9: 1027-1033. PMID 1969794 DOI: 10.1002/J.1460-2075.1990.Tb08206.X  0.421
1988 Ouellette M, Gerbaud G, Courvalin P. Genetic, biochemical and molecular characterization of strains of Vibrio cholerae multiresistant to antibiotics Annales De L'Institut Pasteur Microbiology. 139: 105-113. PMID 3260105  0.345
1988 Ouellette M, Paul GC, Philippon AM, Roy PH. Oligonucleotide probes (TEM-1, OXA-1) versus isoelectric focusing in β-lactamase characterization of 114 resistant strains Antimicrobial Agents and Chemotherapy. 32: 397-399. PMID 3259123 DOI: 10.1128/Aac.32.3.397  0.309
1987 Ouellette M, Rossi JJ, Bazin R, Roy PH. Oligonucleotide probes for the detection of TEM-1 and TEM-2 β-lactamase genes and their transposons Canadian Journal of Microbiology. 33: 205-211. PMID 3032386 DOI: 10.1139/M87-035  0.341
1987 Ouellette M, Gerbaud G, Lambert T, Courvalin P. Acquisition by a Campylobacter-like strain of aphA-1, a kanamycin resistance determinant from members of the family Enterobacteriaceae Antimicrobial Agents and Chemotherapy. 31: 1021-1026. PMID 2821885 DOI: 10.1128/Aac.31.7.1021  0.38
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