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William Valdar - Publications

Affiliations: 
Statistics University of North Carolina, Chapel Hill, Chapel Hill, NC 
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Crouse WL, Keele GR, Gastonguay MS, Churchill GA, Valdar W. A Bayesian model selection approach to mediation analysis. Plos Genetics. 18: e1010184. PMID 35533209 DOI: 10.1371/journal.pgen.1010184  0.359
2021 Keele GR, Prokop JW, He H, Holl K, Littrell J, Deal AW, Kim Y, Kyle PB, Attipoe E, Johnson AC, Uhl KL, Sirpilla OL, Jahanbakhsh S, Robinson M, Levy S, ... Valdar W, et al. Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model. Scientific Reports. 11: 2071. PMID 33483609 DOI: 10.1038/s41598-021-81550-8  0.313
2020 Crouse WL, Kelada SNP, Valdar W. Inferring the Allelic Series at QTL in Multiparental Populations. Genetics. PMID 33082282 DOI: 10.1534/genetics.120.303393  0.316
2020 Sigmon JS, Blanchard MW, Baric RS, Bell TA, Brennan J, Brockmann GA, Burks AW, Calabrese JM, Caron KM, Cheney RE, Ciavatta D, Conlon F, Darr DB, Faber J, Franklin C, ... ... Valdar W, et al. Content and Performance of the MiniMUGA Genotyping Array, a New Tool To Improve Rigor and Reproducibility in Mouse Research. Genetics. PMID 33067325 DOI: 10.1534/genetics.120.303596  0.617
2020 Keele GR, Quach BC, Israel JW, Chappell GA, Lewis L, Safi A, Simon JM, Cotney P, Crawford GE, Valdar W, Rusyn I, Furey TS. Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation. Plos Genetics. 16: e1008537. PMID 31961859 DOI: 10.1371/Journal.Pgen.1008537  0.341
2020 Schoenrock SA, Kumar P, Gómez-A A, Dickson PE, Kim SM, Bailey L, Neira S, Riker KD, Farrington J, Gaines CH, Khan S, Wilcox TD, Roy TA, Leonardo MR, Olson AA, ... ... Valdar W, et al. Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine. Psychopharmacology. PMID 31897574 DOI: 10.1007/S00213-019-05429-3  0.373
2020 Woods LS, Prokop J, Keele G, Holl K, He H, Littrell J, Deal A, Valdar W, Garrett M. Integrating Genetic Fine‐mapping in Outbred Rats with a Novel Human Tubule Fibrosis Model Identifies Sept8 as a Gene Involved in Cellular Structure and Kidney Fibrosis The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06988  0.323
2019 Mosedale M, Cai Y, Eaddy JS, Corty RW, Nautiyal M, Watkins PB, Valdar W. Identification of Candidate Risk Factor Genes for Human Idelalisib Toxicity Using a Collaborative Cross Approach. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31501888 DOI: 10.1093/Toxsci/Kfz199  0.343
2019 Keele GR, Crouse WL, Kelada SNP, Valdar W. Determinants of QTL Mapping Power in the Realized Collaborative Cross. G3 (Bethesda, Md.). PMID 30914424 DOI: 10.1534/G3.119.400194  0.405
2019 Shorter JR, Maurizio PL, Bell TA, Shaw GD, Miller DR, Gooch TJ, Spence JS, McMillan L, Valdar W, Pardo-Manuel de Villena F. A Diallel of the Mouse Collaborative Cross Founders Reveals Strong Strain-Specific Maternal Effects on Litter Size. G3 (Bethesda, Md.). PMID 30877080 DOI: 10.1534/G3.118.200847  0.73
2018 Corty RW, Valdar W. vqtl: An R Package for Mean-Variance QTL Mapping. G3 (Bethesda, Md.). PMID 30389795 DOI: 10.1534/G3.118.200642  0.395
2018 Corty RW, Valdar W. QTL Mapping on a Background of Variance Heterogeneity. G3 (Bethesda, Md.). PMID 30389794 DOI: 10.1534/G3.118.200790  0.402
2018 Corty RW, Kumar V, Tarantino LM, Takahashi JS, Valdar W. Mean-Variance QTL Mapping Identifies Novel QTL for Circadian Activity and Exploratory Behavior in Mice. G3 (Bethesda, Md.). PMID 30389793 DOI: 10.1534/G3.118.200194  0.358
2018 Kafkafi N, Agassi J, Chesler EJ, Crabbe JC, Crusio WE, Eilam D, Gerlai R, Golani I, Gomez-Marin A, Heller R, Iraqi F, Jaljuli I, Karp NA, Morgan H, Nicholson G, ... ... Valdar W, et al. Reproducibility and replicability of rodent phenotyping in preclinical studies. Neuroscience and Biobehavioral Reviews. PMID 29357292 DOI: 10.1016/J.Neubiorev.2018.01.003  0.318
2017 Maurizio PL, Ferris MT, Keele GR, Miller DR, Shaw GD, Whitmore AC, West A, Morrison CR, Noll KE, Plante KS, Cockrell AS, Threadgill DW, Pardo-Manuel de Villena F, Baric RS, Heise MT, ... Valdar W, et al. Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice. G3 (Bethesda, Md.). PMID 29187420 DOI: 10.1534/G3.117.300438  0.743
2017 Turner SD, Maurizio PL, Valdar W, Yandell BS, Simon P. Dissecting the Genetic Architecture of Shoot Growth in Carrot (Daucus carota L.) Using a Diallel Mating Design. G3 (Bethesda, Md.). PMID 29187419 DOI: 10.1534/G3.117.300235  0.751
2017 Schoenrock SA, Oreper D, Farrington J, McMullan RC, Ervin R, Miller DR, Pardo-Manuel de Villena F, Valdar W, Tarantino LM. Perinatal nutrition interacts with genetic background to alter behavior in a parent-of-origin dependent manner in adult Collaborative Cross mice. Genes, Brain, and Behavior. PMID 29125223 DOI: 10.1111/Gbb.12438  0.382
2017 Oreper D, Cai Y, Tarantino LM, de Villena FP, Valdar W. Inbred Strain Variant Database (ISVdb): A Repository for Probabilistically Informed Sequence Differences Among the Collaborative Cross Strains and Their Founders. G3 (Bethesda, Md.). 7: 1623-1630. PMID 28592645 DOI: 10.1534/G3.117.041491  0.373
2017 Mosedale M, Kim Y, Brock WJ, Roth SE, Wiltshire T, Scott Eaddy J, Keele GR, Corty RW, Xie Y, Valdar W, Watkins PB. Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28115652 DOI: 10.1093/Toxsci/Kfw269  0.367
2016 Xie Y, Liu Y, Valdar W. Joint Estimation of Multiple Dependent Gaussian Graphical Models with Applications to Mouse Genomics. Biometrika. 103: 493-511. PMID 29038606 DOI: 10.1093/Biomet/Asw035  0.3
2016 Schoenrock SA, Oreper D, Young N, Ervin RB, Bogue MA, Valdar W, Tarantino LM. Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice. Physiology & Behavior. PMID 27693591 DOI: 10.1016/J.Physbeh.2016.09.026  0.355
2015 Gralinski LE, Ferris MT, Aylor DL, Whitmore AC, Green R, Frieman MB, Deming D, Menachery VD, Miller DR, Buus RJ, Bell TA, Churchill GA, Threadgill DW, Katze MG, McMillan L, ... Valdar W, et al. Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. Plos Genetics. 11: e1005504. PMID 26452100 DOI: 10.1371/Journal.Pgen.1005504  0.618
2015 Li J, Lange LA, Sabourin J, Duan Q, Valdar W, Willis MS, Li Y, Wilson JG, Lange EM. Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study. Journal of Human Genetics. PMID 26377243 DOI: 10.1038/Jhg.2015.107  0.73
2015 Durda P, Sabourin J, Lange EM, Nalls MA, Mychaleckyj JC, Jenny NS, Li J, Walston J, Harris TB, Psaty BM, Valdar W, Liu Y, Cushman M, Reiner AP, Tracy RP, et al. Plasma Levels of Soluble IL-2 Receptor α: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26293465 DOI: 10.1161/Atvbaha.115.305289  0.72
2015 Sabourin JA, Valdar W, Nobel AB. A permutation approach for selecting the penalty parameter in penalized model selection. Biometrics. 71: 1185-94. PMID 26243050 DOI: 10.1111/Biom.12359  0.723
2015 Crowley JJ, Zhabotynsky V, Sun W, Huang S, Pakatci IK, Kim Y, Wang JR, Morgan AP, Calaway JD, Aylor DL, Yun Z, Bell TA, Buus RJ, Calaway ME, Didion JP, ... ... Valdar W, et al. Corrigendum: Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance. Nature Genetics. 47: 690. PMID 26018903 DOI: 10.1038/Ng0615-690A  0.309
2015 Crowley JJ, Zhabotynsky V, Sun W, Huang S, Pakatci IK, Kim Y, Wang JR, Morgan AP, Calaway JD, Aylor DL, Yun Z, Bell TA, Buus RJ, Calaway ME, Didion JP, ... ... Valdar W, et al. Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance. Nature Genetics. 47: 353-60. PMID 25730764 DOI: 10.1038/Ng.3222  0.396
2015 Sabourin J, Nobel AB, Valdar W. Fine-mapping additive and dominant SNP effects using group-LASSO and fractional resample model averaging. Genetic Epidemiology. 39: 77-88. PMID 25417853 DOI: 10.1002/Gepi.21869  0.76
2014 Gatti DM, Svenson KL, Shabalin A, Wu LY, Valdar W, Simecek P, Goodwin N, Cheng R, Pomp D, Palmer A, Chesler EJ, Broman KW, Churchill GA. Quantitative trait locus mapping methods for diversity outbred mice. G3 (Bethesda, Md.). 4: 1623-33. PMID 25237114 DOI: 10.1534/G3.114.013748  0.381
2014 Zhang Z, Wang W, Valdar W. Bayesian modeling of haplotype effects in multiparent populations. Genetics. 198: 139-56. PMID 25236455 DOI: 10.1534/Genetics.114.166249  0.441
2014 Leamy LJ, Elo K, Nielsen MK, Thorn SR, Valdar W, Pomp D. Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss. Peerj. 2: e392. PMID 24918027 DOI: 10.7717/Peerj.392  0.418
2014 Crowley JJ, Kim Y, Lenarcic AB, Quackenbush CR, Barrick CJ, Adkins DE, Shaw GS, Miller DR, de Villena FP, Sullivan PF, Valdar W. Genetics of adverse reactions to haloperidol in a mouse diallel: a drug-placebo experiment and Bayesian causal analysis. Genetics. 196: 321-47. PMID 24240528 DOI: 10.1534/Genetics.113.156901  0.377
2014 Phillippi J, Xie Y, Miller DR, Bell TA, Zhang Z, Lenarcic AB, Aylor DL, Krovi SH, Threadgill DW, Pardo-Manuel De Villena F, Wang W, Valdar W, Frelinger JA. Using the emerging Collaborative Cross to probe the immune system Genes and Immunity. 15: 38-46. PMID 24195963 DOI: 10.1038/Gene.2013.59  0.391
2013 Calaway JD, Lenarcic AB, Didion JP, Wang JR, Searle JB, McMillan L, Valdar W, Pardo-Manuel de Villena F. Genetic architecture of skewed X inactivation in the laboratory mouse. Plos Genetics. 9: e1003853. PMID 24098153 DOI: 10.1371/Journal.Pgen.1003853  0.373
2013 Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, et al. Modeling host genetic regulation of influenza pathogenesis in the collaborative cross. Plos Pathogens. 9: e1003196. PMID 23468633 DOI: 10.1371/Journal.Ppat.1003196  0.64
2012 Valdar W, Sabourin J, Nobel A, Holmes CC. Reprioritizing genetic associations in hit regions using LASSO-based resample model averaging. Genetic Epidemiology. 36: 451-62. PMID 22549815 DOI: 10.1002/Gepi.21639  0.762
2012 Zhang W, Korstanje R, Thaisz J, Staedtler F, Harttman N, Xu L, Feng M, Yanas L, Yang H, Valdar W, Churchill GA, Dipetrillo K. Genome-wide association mapping of quantitative traits in outbred mice. G3 (Bethesda, Md.). 2: 167-74. PMID 22384395 DOI: 10.1534/G3.111.001792  0.445
2012 Svenson KL, Gatti DM, Valdar W, Welsh CE, Cheng R, Chesler EJ, Palmer AA, McMillan L, Churchill GA. High-resolution genetic mapping using the Mouse Diversity outbred population. Genetics. 190: 437-47. PMID 22345611 DOI: 10.1534/Genetics.111.132597  0.468
2012 Lenarcic AB, Svenson KL, Churchill GA, Valdar W. General Bayesian approach to analyzing diallel crosses of inbred strains Genetics. 190: 413-435. PMID 22345610 DOI: 10.1534/Genetics.111.132563  0.431
2012 Iraqi FA, Mahajne M, Salaymah Y, Sandovski H, Tayem H, Vered K, Balmer L, Hall M, Manship G, Morahan G, Pettit K, Scholten J, Tweedie K, Wallace A, Weerasekera L, ... ... Valdar W, et al. The genome architecture of the collaborative cross mouse genetic reference population Genetics. 190: 389-401. PMID 22345608 DOI: 10.1534/Genetics.111.132639  0.639
2011 Ahlqvist E, Ekman D, Lindvall T, Popovic M, Förster M, Hultqvist M, Klaczkowska D, Teneva I, Johannesson M, Flint J, Valdar W, Nandakumar KS, Holmdahl R. High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice Human Molecular Genetics. 20: 3031-3041. PMID 21565963 DOI: 10.1093/Hmg/Ddr206  0.399
2011 Johnsen AK, Valdar W, Golden L, Ortiz-Lopez A, Hitzemann R, Flint J, Mathis D, Benoist C. Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice. Arthritis and Rheumatism. 63: 2630-40. PMID 21560115 DOI: 10.1002/Art.30425  0.423
2011 Rönnegård L, Valdar W. Detecting major genetic loci controlling phenotypic variability in experimental crosses. Genetics. 188: 435-47. PMID 21467569 DOI: 10.1534/Genetics.111.127068  0.42
2011 Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JD, Hua K, Nehrenberg DL, et al. Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Research. 21: 1213-22. PMID 21406540 DOI: 10.1101/Gr.111310.110  0.659
2011 Schile A, Svenson KL, Fancher KS, Valdar W, Chesler EJ, Churchill GA. Abstract B10: Diversity Outbred: A new, highly diverse mouse stock for toxicology and cancer. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B10  0.421
2010 Solberg Woods LC, Holl K, Tschannen M, Valdar W. Fine-mapping a locus for glucose tolerance using heterogeneous stock rats. Physiological Genomics. 41: 102-8. PMID 20068026 DOI: 10.1152/Physiolgenomics.00178.2009  0.331
2009 Kover PX, Valdar W, Trakalo J, Scarcelli N, Ehrenreich IM, Purugganan MD, Durrant C, Mott R. A Multiparent Advanced Generation Inter-Cross to fine-map quantitative traits in Arabidopsis thaliana. Plos Genetics. 5: e1000551. PMID 19593375 DOI: 10.1371/Journal.Pgen.1000551  0.419
2009 Valdar W, Holmes CC, Mott R, Flint J. Mapping in structured populations by resample model averaging. Genetics. 182: 1263-77. PMID 19474203 DOI: 10.1534/Genetics.109.100727  0.417
2009 Huang GJ, Shifman S, Valdar W, Johannesson M, Yalcin B, Taylor MS, Taylor JM, Mott R, Flint J. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Research. 19: 1133-40. PMID 19376938 DOI: 10.1101/Gr.088120.108  0.429
2009 Ramagopalan SV, Valdar W, Dyment DA, DeLuca GC, Yee IM, Giovannoni G, Ebers GC, Sadovnick AD. Association of infectious mononucleosis with multiple sclerosis. A population-based study. Neuroepidemiology. 32: 257-62. PMID 19209005 DOI: 10.1159/000201564  0.331
2009 Bice P, Valdar W, Zhang L, Liu L, Lai D, Grahame N, Flint J, Li TK, Lumeng L, Foroud T. Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice Alcoholism: Clinical and Experimental Research. 33: 531-537. PMID 19120064 DOI: 10.1111/J.1530-0277.2008.00866.X  0.353
2009 Johannesson M, Lopez-Aumatell R, Stridh P, Diez M, Tuncel J, Blázquez G, Martinez-Membrives E, Cañete T, Vicens-Costa E, Graham D, Copley RR, Hernandez-Pliego P, Beyeen AD, Ockinger J, Fernández-Santamaría C, ... ... Valdar W, et al. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Research. 19: 150-8. PMID 18971309 DOI: 10.1101/Gr.081497.108  0.406
2009 Willis-Owen SA, Valdar W. Deciphering gene-environment interactions through mouse models of allergic asthma. The Journal of Allergy and Clinical Immunology. 123: 14-23; quiz 24-5. PMID 18926561 DOI: 10.1016/J.Jaci.2008.09.016  0.387
2008 Ramagopalan SV, Herrera BM, Valdar W, Dyment DA, Orton SM, Yee IM, Criscuoli M, Atkins K, Ebers GC, Sadovnick AD. No effect of birth weight on the risk of multiple sclerosis. A population-based study. Neuroepidemiology. 31: 181-4. PMID 18784417 DOI: 10.1159/000154931  0.331
2007 Taylor M, Valdar W, Kumar A, Flint J, Mott R. Management, presentation and interpretation of genome scans using GSCANDB. Bioinformatics (Oxford, England). 23: 1545-9. PMID 17400728 DOI: 10.1093/Bioinformatics/Btm123  0.34
2006 Valdar W, Solberg LC, Gauguier D, Cookson WO, Rawlins JN, Mott R, Flint J. Genetic and environmental effects on complex traits in mice. Genetics. 174: 959-84. PMID 16888333 DOI: 10.1534/Genetics.106.060004  0.397
2006 Valdar W, Solberg LC, Gauguier D, Burnett S, Klenerman P, Cookson WO, Taylor MS, Rawlins JN, Mott R, Flint J. Genome-wide genetic association of complex traits in heterogeneous stock mice. Nature Genetics. 38: 879-87. PMID 16832355 DOI: 10.1038/Ng1840  0.452
2006 Solberg LC, Valdar W, Gauguier D, Nunez G, Taylor A, Burnett S, Arboledas-Hita C, Hernandez-Pliego P, Davidson S, Burns P, Bhattacharya S, Hough T, Higgs D, Klenerman P, Cookson WO, et al. A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 17: 129-46. PMID 16465593 DOI: 10.1007/S00335-005-0112-1  0.439
2006 Valdar W, Flint J, Mott R. Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice. Genetics. 172: 1783-97. PMID 16361245 DOI: 10.1534/Genetics.104.039313  0.412
2005 Flint J, Valdar W, Shifman S, Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nature Reviews. Genetics. 6: 271-86. PMID 15803197 DOI: 10.1038/Nrg1576  0.403
2004 Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, ... ... Valdar W, et al. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics. 36: 1133-7. PMID 15514660 DOI: 10.1038/Ng1104-1133  0.387
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