Alexandre Prat - Publications

Affiliations: 
Immunology and Microbiology Université de Montréal, Montréal, Canada 
Area:
Immunology, Neuroscience Biology

122 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ayrignac X, Letourneau-Guillon L, Carra-Dallière C, Duquette P, Girard M, Poirier J, Lahav B, Larochelle C, Prat A. From Baló's concentric sclerosis to multiple sclerosis: a series of 6 patients. Multiple Sclerosis and Related Disorders. 42: 102078. PMID 32408148 DOI: 10.1016/j.msard.2020.102078  0.56
2020 Malpas CB, Manouchehrinia A, Sharmin S, Roos I, Horakova D, Havrdova EK, Trojano M, Izquierdo G, Eichau S, Bergamaschi R, Sola P, Ferraro D, Lugaresi A, Prat A, Girard M, et al. Early clinical markers of aggressive multiple sclerosis. Brain : a Journal of Neurology. PMID 32386427 DOI: 10.1093/brain/awaa081  0.56
2020 He A, Merkel B, Brown JWL, Zhovits Ryerson L, Kister I, Malpas CB, Sharmin S, Horakova D, Kubala Havrdova E, Spelman T, Izquierdo G, Eichau S, Trojano M, Lugaresi A, Hupperts R, ... ... Prat A, et al. Timing of high-efficacy therapy for multiple sclerosis: a retrospective observational cohort study. The Lancet. Neurology. 19: 307-316. PMID 32199096 DOI: 10.1016/S1474-4422(20)30067-3  0.56
2020 Antel JP, Becher B, Ludwin SK, Prat A, Quintana FJ. Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System. Journal of Immunology (Baltimore, Md. : 1950). 204: 251-255. PMID 31907266 DOI: 10.4049/jimmunol.1900908  0.36
2019 Michel L, Grasmuck C, Charabati M, Lécuyer MA, Zandee S, Dhaeze T, Alvarez JI, Li R, Larouche S, Bourbonnière L, Moumdjian R, Bouthillier A, Lahav B, Duquette P, Bar-Or A, ... ... Prat A, et al. Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers. Science Translational Medicine. 11. PMID 31723036 DOI: 10.1126/scitranslmed.aaw0475  0.56
2019 Fambiatos A, Jokubaitis V, Horakova D, Kubala Havrdova E, Trojano M, Prat A, Girard M, Duquette P, Lugaresi A, Izquierdo G, Grand'Maison F, Grammond P, Sola P, Ferraro D, Alroughani R, et al. Risk of secondary progressive multiple sclerosis: A longitudinal study. Multiple Sclerosis (Houndmills, Basingstoke, England). 1352458519868990. PMID 31397221 DOI: 10.1177/1352458519868990  0.56
2019 Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, ... ... Prat A, et al. Author Correction: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nature Neuroscience. PMID 31197266 DOI: 10.1038/s41593-019-0446-8  0.32
2019 Ayrignac X, Bilodeau PA, Prat A, Girard M, Labauge P, Le Lorier J, Larochelle C, Duquette P. Assessing the risk of multiple sclerosis disease-modifying therapies. Expert Review of Neurotherapeutics. PMID 31195842 DOI: 10.1080/14737175.2019.1627201  0.56
2019 Brown JWL, Coles A, Horakova D, Havrdova E, Izquierdo G, Prat A, Girard M, Duquette P, Trojano M, Lugaresi A, Bergamaschi R, Grammond P, Alroughani R, Hupperts R, McCombe P, et al. Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis. Jama. 321: 175-187. PMID 30644981 DOI: 10.1001/jama.2018.20588  0.56
2019 Kalincik T, Kubala Havrdova E, Horakova D, Izquierdo G, Prat A, Girard M, Duquette P, Grammond P, Onofrj M, Lugaresi A, Ozakbas S, Kappos L, Kuhle J, Terzi M, Lechner-Scott J, et al. Comparison of fingolimod, dimethyl fumarate and teriflunomide for multiple sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 30636699 DOI: 10.1136/jnnp-2018-319831  0.56
2019 Dhaeze T, Tremblay L, Lachance C, Peelen E, Zandee S, Grasmuck C, Bourbonnière L, Larouche S, Ayrignac X, Rébillard RM, Poirier J, Lahav B, Duquette P, Girard M, Moumdjian R, ... ... Prat A, et al. CD70 defines a subset of proinflammatory and CNS-pathogenic T1/T17 lymphocytes and is overexpressed in multiple sclerosis. Cellular & Molecular Immunology. PMID 30635649 DOI: 10.1038/s41423-018-0198-5  0.56
2019 Nguyen AL, Havrdova EK, Horakova D, Izquierdo G, Kalincik T, van der Walt A, Terzi M, Alroughani R, Duquette P, Girard M, Prat A, Boz C, Sola P, Ferraro D, Lugaresi A, et al. Incidence of pregnancy and disease-modifying therapy exposure trends in women with multiple sclerosis: A contemporary cohort study. Multiple Sclerosis and Related Disorders. 28: 235-243. PMID 30623864 DOI: 10.1016/j.msard.2019.01.003  0.56
2018 Lorscheider J, Kuhle J, Izquierdo G, Lugaresi A, Havrdova E, Horakova D, Hupperts R, Duquette P, Girard M, Prat A, Grand'Maison F, Grammond P, Sola P, Ferraro D, Trojano M, et al. Anti-inflammatory disease modifying treatment and disability progression in primary progressive multiple sclerosis: a cohort study. European Journal of Neurology. PMID 30298572 DOI: 10.1111/ene.13824  0.56
2018 Hughes J, Jokubaitis V, Lugaresi A, Hupperts R, Izquierdo G, Prat A, Girard M, Duquette P, Grand'Maison F, Grammond P, Sola P, Ferraro D, Ramo-Tello C, Trojano M, Slee M, et al. Association of Inflammation and Disability Accrual in Patients With Progressive-Onset Multiple Sclerosis. Jama Neurology. PMID 30083762 DOI: 10.1001/jamaneurol.2018.2109  0.56
2018 Kebir H, Carmant L, Fontaine F, Béland K, Bosoi CM, Sanon NT, Alvarez JI, Desgent S, Pittet CL, Hébert D, Langlois MJ, Rébillard RM, Nguyen DK, Cieuta-Walti C, Holmes GL, ... ... Prat A, et al. Humanized mouse model of Rasmussen's encephalitis supports the immune-mediated hypothesis. The Journal of Clinical Investigation. PMID 29629902 DOI: 10.1172/JCI97098  0.44
2017 Kalincik T, Manouchehrinia A, Sobisek L, Jokubaitis V, Spelman T, Horakova D, Havrdova E, Trojano M, Izquierdo G, Lugaresi A, Girard M, Prat A, Duquette P, Grammond P, Sola P, et al. Towards personalized therapy for multiple sclerosis: prediction of individual treatment response. Brain : a Journal of Neurology. 140: 2426-2443. PMID 29050389 DOI: 10.1093/brain/awx185  0.56
2017 Kalincik T, Jokubaitis V, Spelman T, Horakova D, Havrdova E, Trojano M, Lechner-Scott J, Lugaresi A, Prat A, Girard M, Duquette P, Grammond P, Solaro C, Grand'Maison F, Hupperts R, et al. Cladribine versus fingolimod, natalizumab and interferon β for multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England). 1352458517728812. PMID 28857680 DOI: 10.1177/1352458517728812  0.56
2017 Lorscheider J, Jokubaitis VG, Spelman T, Izquierdo G, Lugaresi A, Havrdova E, Horakova D, Trojano M, Duquette P, Girard M, Prat A, Grand'Maison F, Grammond P, Pucci E, Boz C, et al. Anti-inflammatory disease-modifying treatment and short-term disability progression in SPMS. Neurology. PMID 28794248 DOI: 10.1212/WNL.0000000000004330  0.56
2017 Ifergan I, Davidson TS, Kebir H, Xu D, Palacios-Macapagal D, Cann J, Rodgers JM, Hunter ZN, Pittet CL, Beddow S, Jones CA, Prat A, Sleeman MA, Miller SD. Targeting the GM-CSF receptor for the treatment of CNS autoimmunity. Journal of Autoimmunity. PMID 28641926 DOI: 10.1016/j.jaut.2017.06.005  0.8
2017 Signori A, Izquierdo G, Lugaresi A, Hupperts R, Grand'Maison F, Sola P, Horakova D, Havrdova E, Prat A, Girard M, Duquette P, Boz C, Grammond P, Terzi M, Singhal B, et al. Long-term disability trajectories in primary progressive MS patients: A latent class growth analysis. Multiple Sclerosis (Houndmills, Basingstoke, England). 1352458517703800. PMID 28382837 DOI: 10.1177/1352458517703800  0.56
2017 Lühder F, Kebir H, Odoardi F, Litke T, Sonneck M, Alvarez JI, Winchenbach J, Eckert N, Hayardeny L, Sorani E, Lodygin D, Flügel A, Prat A. Laquinimod enhances central nervous system barrier functions. Neurobiology of Disease. PMID 28235673 DOI: 10.1016/j.nbd.2017.02.002  0.44
2017 Kalincik T, Brown JW, Robertson N, Willis M, Scolding N, Rice CM, Wilkins A, Pearson O, Ziemssen T, Hutchinson M, McGuigan C, Jokubaitis V, Spelman T, Horakova D, Havrdova E, ... ... Prat A, et al. Treatment effectiveness of alemtuzumab compared with natalizumab, fingolimod, and interferon beta in relapsing-remitting multiple sclerosis: a cohort study. The Lancet. Neurology. PMID 28209331 DOI: 10.1016/S1474-4422(17)30007-8  0.56
2016 Kuhlmann T, Ludwin S, Prat A, Antel J, Brück W, Lassmann H. An updated histological classification system for multiple sclerosis lesions. Acta Neuropathologica. PMID 27988845 DOI: 10.1007/s00401-016-1653-y  0.32
2016 Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, ... ... Prat A, et al. Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nature Immunology. 17: 1479. PMID 27849203 DOI: 10.1038/ni1216-1479c  0.52
2016 Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, ... ... Prat A, et al. USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nature Immunology. PMID 27721430 DOI: 10.1038/ni.3581  0.8
2016 Lizak N, Lugaresi A, Alroughani R, Lechner-Scott J, Slee M, Havrdova E, Horakova D, Trojano M, Izquierdo G, Duquette P, Girard M, Prat A, Grammond P, Hupperts R, Grand'Maison F, et al. Highly active immunomodulatory therapy ameliorates accumulation of disability in moderately advanced and advanced multiple sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 27683916 DOI: 10.1136/jnnp-2016-313976  0.56
2016 Lorscheider J, Buzzard K, Jokubaitis V, Spelman T, Havrdova E, Horakova D, Trojano M, Izquierdo G, Girard M, Duquette P, Prat A, Lugaresi A, Grand'Maison F, Grammond P, Hupperts R, et al. Defining secondary progressive multiple sclerosis. Brain : a Journal of Neurology. PMID 27401521 DOI: 10.1093/brain/aww173  0.56
2016 Mayo L, Cunha AP, Madi A, Beynon V, Yang Z, Alvarez JI, Prat A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL. IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain : a Journal of Neurology. PMID 27246324 DOI: 10.1093/brain/aww113  0.8
2016 Rothhammer V, Mascanfroni ID, Bunse L, Takenaka MC, Kenison JE, Mayo L, Chao CC, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, ... ... Prat A, et al. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nature Medicine. PMID 27158906 DOI: 10.1038/nm.4106  0.8
2016 Jokubaitis VG, Spelman T, Kalincik T, Lorscheider J, Havrdova E, Horakova D, Duquette P, Girard M, Prat A, Izquierdo G, Grammond P, Van Pesch V, Pucci E, Grand'Maison F, Hupperts R, et al. Predictors of long-term disability accrual in relapse-onset multiple sclerosis. Annals of Neurology. PMID 27145331 DOI: 10.1002/ana.24682  0.8
2016 Lévesque SA, Paré A, Mailhot B, Bellver-Landete V, Kébir H, Lécuyer MA, Alvarez JI, Prat A, Vaccari JP, Keane RW, Lacroix S. Myeloid cell transmigration across the CNS vasculature triggers IL-1β-driven neuroinflammation during autoimmune encephalomyelitis in mice. The Journal of Experimental Medicine. PMID 27139491 DOI: 10.1084/jem.20151437  0.8
2016 Spelman T, Kalincik T, Jokubaitis V, Zhang A, Pellegrini F, Wiendl H, Belachew S, Hyde R, Verheul F, Lugaresi A, Havrdová E, Horáková D, Grammond P, Duquette P, Prat A, et al. Comparative efficacy of first-line natalizumab vs IFN-β or glatiramer acetate in relapsing MS. Neurology. Clinical Practice. 6: 102-115. PMID 27104064 DOI: 10.1212/CPJ.0000000000000227  0.8
2016 Stewart T, Spelman T, Havrdova E, Horakova D, Trojano M, Izquierdo G, Duquette P, Girard M, Prat A, Lugaresi A, Grand'Maison F, Grammond P, Sola P, Shaygannejad V, Hupperts R, et al. Contribution of different relapse phenotypes to disability in multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England). PMID 27055805 DOI: 10.1177/1352458516643392  0.56
2016 Luo H, Broux B, Wang X, Hu Y, Ghannam S, Jin W, Larochelle C, Prat A, Wu J. EphrinB1 and EphrinB2 regulate T cell chemotaxis and migration in experimental autoimmune encephalomyelitis and multiple sclerosis. Neurobiology of Disease. PMID 27039370 DOI: 10.1016/j.nbd.2016.03.013  0.8
2016 Larochelle C, Metz I, Lécuyer MA, Terouz S, Roger M, Arbour N, Brück W, Prat A. Immunological and pathological characterization of fatal rebound MS activity following natalizumab withdrawal. Multiple Sclerosis (Houndmills, Basingstoke, England). PMID 27037182 DOI: 10.1177/1352458516641775  0.52
2016 Larochelle C, Uphaus T, Prat A, Zipp F. Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology? Trends in Neurosciences. PMID 26987259 DOI: 10.1016/j.tins.2016.02.001  0.8
2016 Michel L, Prat A. One more role for the gut: microbiota and blood brain barrier. Annals of Translational Medicine. 4: 15. PMID 26855951 DOI: 10.3978/j.issn.2305-5839.2015.10.16  0.8
2016 Lécuyer MA, Kebir H, Prat A. Glial influences on BBB functions and molecular players in immune cell trafficking. Biochimica Et Biophysica Acta. 1862: 472-82. PMID 26454208 DOI: 10.1016/j.bbadis.2015.10.004  0.8
2015 Li R, Rezk A, Healy LM, Muirhead G, Prat A, Gommerman JL, Bar-Or A. Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis. Frontiers in Immunology. 6: 626. PMID 26779181 DOI: 10.3389/fimmu.2015.00626  0.8
2015 Alvarez JI, Kébir H, Cheslow L, Chabarati M, Larochelle C, Prat A. JAML mediates monocyte and CD8 T cell migration across the brain endothelium. Annals of Clinical and Translational Neurology. 2: 1032-7. PMID 26734656 DOI: 10.1002/acn3.255  0.56
2015 Michel L, Touil H, Pikor NB, Gommerman JL, Prat A, Bar-Or A. B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized Inflammation. Frontiers in Immunology. 6: 636. PMID 26732544 DOI: 10.3389/fimmu.2015.00636  0.8
2015 Pikor NB, Astarita JL, Summers-Deluca L, Galicia G, Qu J, Ward LA, Armstrong S, Dominguez CX, Malhotra D, Heiden B, Kay R, Castanov V, Touil H, Boon L, O'Connor P, ... ... Prat A, et al. Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation. Immunity. 43: 1160-73. PMID 26682987 DOI: 10.1016/j.immuni.2015.11.010  0.8
2015 Sénécal V, Deblois G, Beauseigle D, Schneider R, Brandenburg J, Newcombe J, Moore CS, Prat A, Antel J, Arbour N. Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses. Glia. PMID 26649511 DOI: 10.1002/glia.22948  0.52
2015 Li R, Rezk A, Miyazaki Y, Hilgenberg E, Touil H, Shen P, Moore CS, Michel L, Althekair F, Rajasekharan S, Gommerman JL, Prat A, Fillatreau S, Bar-Or A. Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy. Science Translational Medicine. 7: 310ra166. PMID 26491076 DOI: 10.1126/scitranslmed.aab4176  0.8
2015 Kalincik T, Cutter G, Spelman T, Jokubaitis V, Havrdova E, Horakova D, Trojano M, Izquierdo G, Girard M, Duquette P, Prat A, Lugaresi A, Grand'Maison F, Grammond P, Hupperts R, et al. Defining reliable disability outcomes in multiple sclerosis. Brain : a Journal of Neurology. 138: 3287-98. PMID 26359291 DOI: 10.1093/brain/awv258  0.8
2015 Broux B, Gowing E, Prat A. Glial regulation of the blood-brain barrier in health and disease. Seminars in Immunopathology. 37: 577-90. PMID 26245144 DOI: 10.1007/s00281-015-0516-2  0.8
2015 Podjaski C, Alvarez JI, Bourbonniere L, Larouche S, Terouz S, Bin JM, Lécuyer MA, Saint-Laurent O, Larochelle C, Darlington PJ, Arbour N, Antel JP, Kennedy TE, Prat A. Netrin 1 regulates blood-brain barrier function and neuroinflammation. Brain : a Journal of Neurology. 138: 1598-612. PMID 25903786 DOI: 10.1093/brain/awv092  0.52
2015 Larochelle C, Lécuyer MA, Alvarez JI, Charabati M, Saint-Laurent O, Ghannam S, Kebir H, Flanagan K, Yednock T, Duquette P, Arbour N, Prat A. Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation. Annals of Neurology. 78: 39-53. PMID 25869475 DOI: 10.1002/ana.24415  0.8
2015 Legroux L, Pittet CL, Beauseigle D, Deblois G, Prat A, Arbour N. An optimized method to process mouse CNS to simultaneously analyze neural cells and leukocytes by flow cytometry. Journal of Neuroscience Methods. 247: 23-31. PMID 25819540 DOI: 10.1016/j.jneumeth.2015.03.021  0.8
2015 Michel L, Larochelle C, Prat A. Update on treatments in multiple sclerosis. Presse MéDicale (Paris, France : 1983). 44: e137-51. PMID 25813102 DOI: 10.1016/j.lpm.2015.02.008  0.8
2015 Daneman R, Prat A. The blood-brain barrier. Cold Spring Harbor Perspectives in Biology. 7: a020412. PMID 25561720 DOI: 10.1101/cshperspect.a020412  0.8
2015 Alvarez JI, Saint-Laurent O, Godschalk A, Terouz S, Briels C, Larouche S, Bourbonnière L, Larochelle C, Prat A. Focal disturbances in the blood-brain barrier are associated with formation of neuroinflammatory lesions. Neurobiology of Disease. 74: 14-24. PMID 25448765 DOI: 10.1016/j.nbd.2014.09.016  0.8
2015 Duquette P, Prat A. How safe is natalizumab during pregnancy? Multiple Sclerosis (Houndmills, Basingstoke, England). 21: 121-2. PMID 25392323 DOI: 10.1177/1352458514555789  0.8
2014 Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, et al. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nature Medicine. 20: 1147-56. PMID 25216636 DOI: 10.1038/nm.3681  0.8
2014 Miyazaki Y, Li R, Rezk A, Misirliyan H, Moore C, Farooqi N, Solis M, Goiry LG, de Faria Junior O, Dang VD, Colman D, Dhaunchak AS, Antel J, Gommerman J, Prat A, et al. A novel microRNA-132-surtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis. Plos One. 9: e105421. PMID 25136908 DOI: 10.1371/journal.pone.0105421  0.8
2014 Aubé B, Lévesque SA, Paré A, Chamma É, Kébir H, Gorina R, Lécuyer MA, Alvarez JI, De Koninck Y, Engelhardt B, Prat A, Côté D, Lacroix S. Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases Journal of Immunology. 193: 2438-2454. PMID 25049355 DOI: 10.4049/jimmunol.1400401  0.8
2014 Larochelle C, Grand'maison F, Bernier GP, Latour M, Cailhier JF, Prat A. Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in relapsing-remitting multiple sclerosis patients on high-dose interferon β. Multiple Sclerosis (Houndmills, Basingstoke, England). 20: 1783-7. PMID 24534079 DOI: 10.1177/1352458514523692  0.8
2013 Schwartz M, Kipnis J, Rivest S, Prat A. How do immune cells support and shape the brain in health, disease, and aging? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17587-96. PMID 24198349 DOI: 10.1523/JNEUROSCI.3241-13.2013  0.8
2013 Alvarez JI, Katayama T, Prat A. Glial influence on the blood brain barrier. Glia. 61: 1939-58. PMID 24123158 DOI: 10.1002/glia.22575  0.8
2013 Pickles S, Cadieux-Dion M, Alvarez JI, Lécuyer MA, Peyrard SL, Destroismaisons L, St-Onge L, Terouz S, Cossette P, Prat A, Vande Velde C. Endo-MitoEGFP mice: a novel transgenic mouse with fluorescently marked mitochondria in microvascular endothelial cells. Plos One. 8: e74603. PMID 24019971 DOI: 10.1371/journal.pone.0074603  0.8
2013 Brück W, Gold R, Lund BT, Oreja-Guevara C, Prat A, Spencer CM, Steinman L, Tintoré M, Vollmer TL, Weber MS, Weiner LP, Ziemssen T, Zamvil SS. Therapeutic decisions in multiple sclerosis: moving beyond efficacy. Jama Neurology. 70: 1315-24. PMID 23921521 DOI: 10.1001/jamaneurol.2013.3510  0.8
2013 Agrawal SM, Williamson J, Sharma R, Kebir H, Patel K, Prat A, Yong VW. Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis. Brain : a Journal of Neurology. 136: 1760-77. PMID 23687119 DOI: 10.1093/brain/awt093  0.8
2013 Freedman MS, Selchen D, Arnold DL, Prat A, Banwell B, Yeung M, Morgenthau D, Lapierre Y. Treatment optimization in MS: Canadian MS Working Group updated recommendations. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 40: 307-23. PMID 23603165  0.8
2013 Reijerkerk A, Lopez-Ramirez MA, van Het Hof B, Drexhage JA, Kamphuis WW, Kooij G, Vos JB, van der Pouw Kraan TC, van Zonneveld AJ, Horrevoets AJ, Prat A, Romero IA, de Vries HE. MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6857-63. PMID 23595744 DOI: 10.1523/JNEUROSCI.3965-12.2013  0.8
2013 Darlington PJ, Touil T, Doucet JS, Gaucher D, Zeidan J, Gauchat D, Corsini R, Kim HJ, Duddy M, Jalili F, Arbour N, Kebir H, Chen J, Arnold DL, Bowman M, ... ... Prat A, et al. Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation. Annals of Neurology. 73: 341-54. PMID 23463494 DOI: 10.1002/ana.23784  0.8
2013 Zaguia F, Saikali P, Ludwin S, Newcombe J, Beauseigle D, McCrea E, Duquette P, Prat A, Antel JP, Arbour N. Cytotoxic NKG2C+ CD4 T cells target oligodendrocytes in multiple sclerosis. Journal of Immunology (Baltimore, Md. : 1950). 190: 2510-8. PMID 23396942 DOI: 10.4049/jimmunol.1202725  0.8
2013 Mizee MR, Wooldrik D, Lakeman KA, van het Hof B, Drexhage JA, Geerts D, Bugiani M, Aronica E, Mebius RE, Prat A, de Vries HE, Reijerkerk A. Retinoic acid induces blood-brain barrier development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1660-71. PMID 23345238 DOI: 10.1523/JNEUROSCI.1338-12.2013  0.8
2013 Muldoon LL, Alvarez JI, Begley DJ, Boado RJ, Del Zoppo GJ, Doolittle ND, Engelhardt B, Hallenbeck JM, Lonser RR, Ohlfest JR, Prat A, Scarpa M, Smeyne RJ, Drewes LR, Neuwelt EA. Immunologic privilege in the central nervous system and the blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 13-21. PMID 23072749 DOI: 10.1038/jcbfm.2012.153  0.8
2012 Larochelle C, Cayrol R, Kebir H, Alvarez JI, Lécuyer MA, Ifergan I, Viel É, Bourbonnière L, Beauseigle D, Terouz S, Hachehouche L, Gendron S, Poirier J, Jobin C, Duquette P, ... ... Prat A, et al. Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system. Brain : a Journal of Neurology. 135: 2906-24. PMID 22975388 DOI: 10.1093/brain/aws212  0.8
2012 Flanagan K, Fitzgerald K, Baker J, Regnstrom K, Gardai S, Bard F, Mocci S, Seto P, You M, Larochelle C, Prat A, Chow S, Li L, Vandevert C, Zago W, et al. Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS. Plos One. 7: e40443. PMID 22792325 DOI: 10.1371/journal.pone.0040443  0.8
2012 Zhang MA, Rego D, Moshkova M, Kebir H, Chruscinski A, Nguyen H, Akkermann R, Stanczyk FZ, Prat A, Steinman L, Dunn SE. Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way. Proceedings of the National Academy of Sciences of the United States of America. 109: 9505-10. PMID 22647601 DOI: 10.1073/pnas.1118458109  0.8
2012 Berard JL, Zarruk JG, Arbour N, Prat A, Yong VW, Jacques FH, Akira S, David S. Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis. Glia. 60: 1145-59. PMID 22499213 DOI: 10.1002/glia.22342  0.8
2012 Prat A, Stüve O. Firategrast: natalizumab in a pill? The Lancet. Neurology. 11: 120-1. PMID 22226930 DOI: 10.1016/S1474-4422(11)70306-4  0.8
2011 Ifergan I, Kebir H, Terouz S, Alvarez JI, Lécuyer MA, Gendron S, Bourbonnière L, Dunay IR, Bouthillier A, Moumdjian R, Fontana A, Haqqani A, Klopstein A, Prinz M, López-Vales R, ... ... Prat A, et al. Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions. Annals of Neurology. 70: 751-63. PMID 22162058 DOI: 10.1002/ana.22519  0.8
2011 Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, Sabbagh M, Wosik K, Bourbonnière L, Bernard M, van Horssen J, de Vries HE, Charron F, Prat A. The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science (New York, N.Y.). 334: 1727-31. PMID 22144466 DOI: 10.1126/science.1206936  0.8
2011 Pittet CL, Newcombe J, Prat A, Arbour N. Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis. Journal of Neuroinflammation. 8: 155. PMID 22067141 DOI: 10.1186/1742-2094-8-155  0.52
2011 Ifergan I, Kebir H, Alvarez JI, Marceau G, Bernard M, Bourbonnière L, Poirier J, Duquette P, Talbot PJ, Arbour N, Prat A. Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on α4 integrin. Brain : a Journal of Neurology. 134: 3560-77. PMID 22058139 DOI: 10.1093/brain/awr268  0.8
2011 Schneider R, Mohebiany AN, Ifergan I, Beauseigle D, Duquette P, Prat A, Arbour N. B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients. Journal of Immunology (Baltimore, Md. : 1950). 187: 4119-28. PMID 21911607 DOI: 10.4049/jimmunol.1100885  0.8
2011 Larochelle C, Alvarez JI, Prat A. How do immune cells overcome the blood-brain barrier in multiple sclerosis? Febs Letters. 585: 3770-80. PMID 21550344 DOI: 10.1016/j.febslet.2011.04.066  0.8
2011 Prat A. Special issue on molecular basis of multiple sclerosis. Biochimica Et Biophysica Acta. 1812: 131. PMID 21168062 DOI: 10.1016/j.bbadis.2010.12.003  0.8
2011 Cayrol R, Haqqani AS, Ifergan I, Dodelet-Devillers A, Prat A. Isolation of human brain endothelial cells and characterization of lipid raft-associated proteins by mass spectroscopy. Methods in Molecular Biology (Clifton, N.J.). 686: 275-95. PMID 21082377 DOI: 10.1007/978-1-60761-938-3_13  0.8
2011 Alvarez JI, Cayrol R, Prat A. Disruption of central nervous system barriers in multiple sclerosis. Biochimica Et Biophysica Acta. 1812: 252-64. PMID 20619340 DOI: 10.1016/j.bbadis.2010.06.017  0.8
2009 Kebir H, Ifergan I, Alvarez JI, Bernard M, Poirier J, Arbour N, Duquette P, Prat A. Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis. Annals of Neurology. 66: 390-402. PMID 19810097 DOI: 10.1002/ana.21748  0.8
2009 Schulze-Topphoff U, Prat A, Prozorovski T, Siffrin V, Paterka M, Herz J, Bendix I, Ifergan I, Schadock I, Mori MA, Van Horssen J, Schröter F, Smorodchenko A, Han MH, Bader M, et al. Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system. Nature Medicine. 15: 788-93. PMID 19561616 DOI: 10.1038/nm.1980  0.8
2009 Dodelet-Devillers A, Cayrol R, van Horssen J, Haqqani AS, de Vries HE, Engelhardt B, Greenwood J, Prat A. Functions of lipid raft membrane microdomains at the blood-brain barrier. Journal of Molecular Medicine (Berlin, Germany). 87: 765-74. PMID 19484210 DOI: 10.1007/s00109-009-0488-6  0.8
2009 Chintawar S, Cayrol R, Antel J, Pandolfo M, Prat A. Blood-brain barrier promotes differentiation of human fetal neural precursor cells. Stem Cells (Dayton, Ohio). 27: 838-46. PMID 19350685 DOI: 10.1002/stem.25  0.8
2008 Vincent T, Saikali P, Cayrol R, Roth AD, Bar-Or A, Prat A, Antel JP. Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment. Journal of Immunology (Baltimore, Md. : 1950). 181: 5730-7. PMID 18832732  0.8
2008 Niemelä J, Ifergan I, Yegutkin GG, Jalkanen S, Prat A, Airas L. IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. European Journal of Immunology. 38: 2718-26. PMID 18825744 DOI: 10.1002/eji.200838437  0.8
2008 Cailhier JF, Sirois I, Laplante P, Lepage S, Raymond MA, Brassard N, Prat A, Iozzo RV, Pshezhetsky AV, Hébert MJ. Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis. The Journal of Biological Chemistry. 283: 27220-9. PMID 18658137 DOI: 10.1074/jbc.M801164200  0.8
2008 Cayrol R, Wosik K, Berard JL, Dodelet-Devillers A, Ifergan I, Kebir H, Haqqani AS, Kreymborg K, Krug S, Moumdjian R, Bouthillier A, Becher B, Arbour N, David S, Stanimirovic D, ... Prat A, et al. Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system. Nature Immunology. 9: 137-45. PMID 18157132 DOI: 10.1038/ni1551  0.8
2008 Ifergan I, Kébir H, Bernard M, Wosik K, Dodelet-Devillers A, Cayrol R, Arbour N, Prat A. The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. Brain : a Journal of Neurology. 131: 785-99. PMID 18156156 DOI: 10.1093/brain/awm295  0.8
2007 Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, Giuliani F, Arbour N, Becher B, Prat A. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nature Medicine. 13: 1173-5. PMID 17828272 DOI: 10.1038/nm1651  0.8
2007 Jack CS, Arbour N, Blain M, Meier UC, Prat A, Antel JP. Th1 polarization of CD4+ T cells by Toll-like receptor 3-activated human microglia. Journal of Neuropathology and Experimental Neurology. 66: 848-59. PMID 17805015 DOI: 10.1097/nen.0b013e3181492a7  0.52
2007 Wosik K, Cayrol R, Dodelet-Devillers A, Berthelet F, Bernard M, Moumdjian R, Bouthillier A, Reudelhuber TL, Prat A. Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 9032-42. PMID 17715340 DOI: 10.1523/JNEUROSCI.2088-07.2007  0.8
2007 Wosik K, Biernacki K, Khouzam MP, Prat A. Death receptor expression and function at the human blood brain barrier. Journal of the Neurological Sciences. 259: 53-60. PMID 17395209 DOI: 10.1016/j.jns.2006.08.018  0.8
2007 Lee G, Babakhanian K, Ramaswamy M, Prat A, Wosik K, Bendayan R. Expression of the ATP-binding cassette membrane transporter, ABCG2, in human and rodent brain microvessel endothelial and glial cell culture systems. Pharmaceutical Research. 24: 1262-74. PMID 17380269 DOI: 10.1007/s11095-007-9244-1  0.8
2007 Saikali P, Antel JP, Newcombe J, Chen Z, Freedman M, Blain M, Cayrol R, Prat A, Hall JA, Arbour N. NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1220-8. PMID 17267578 DOI: 10.1523/JNEUROSCI.4402-06.2007  0.8
2006 Ifergan I, Wosik K, Cayrol R, Kébir H, Auger C, Bernard M, Bouthillier A, Moumdjian R, Duquette P, Prat A. Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Annals of Neurology. 60: 45-55. PMID 16729291 DOI: 10.1002/ana.20875  0.8
2005 Prat A, Antel J. Pathogenesis of multiple sclerosis. Current Opinion in Neurology. 18: 225-30. PMID 15891404  0.8
2005 Prat A, Biernacki K, Antel JP. Th1 and Th2 lymphocyte migration across the human BBB is specifically regulated by interferon beta and copolymer-1. Journal of Autoimmunity. 24: 119-24. PMID 15829404 DOI: 10.1016/j.jaut.2005.01.004  0.8
2004 Biernacki K, Prat A, Blain M, Antel JP. Regulation of cellular and molecular trafficking across human brain endothelial cells by Th1- and Th2-polarized lymphocytes. Journal of Neuropathology and Experimental Neurology. 63: 223-32. PMID 15055446  0.8
2003 Séguin R, Biernacki K, Rotondo RL, Prat A, Antel JP. Regulation and functional effects of monocyte migration across human brain-derived endothelial cells. Journal of Neuropathology and Experimental Neurology. 62: 412-9. PMID 12722833  0.8
2003 Alter A, Duddy M, Hebert S, Biernacki K, Prat A, Antel JP, Yong VW, Nuttall RK, Pennington CJ, Edwards DR, Bar-Or A. Determinants of human B cell migration across brain endothelial cells. Journal of Immunology (Baltimore, Md. : 1950). 170: 4497-505. PMID 12707326  0.8
2003 Séguin R, Biernacki K, Prat A, Wosik K, Kim HJ, Blain M, McCrea E, Bar-Or A, Antel JP. Differential effects of Th1 and Th2 lymphocyte supernatants on human microglia. Glia. 42: 36-45. PMID 12594735 DOI: 10.1002/glia.10201  0.56
2003 Séguin R, Moditi Z, Rotondo R, Biernacki K, Wosik K, Prat A, Antel JP. Human brain endothelial cells supply support for monocyte immunoregulatory functions. Journal of Neuroimmunology. 135: 96-106. PMID 12576229  0.56
2002 Prat A, Biernacki K, Lavoie JF, Poirier J, Duquette P, Antel JP. Migration of multiple sclerosis lymphocytes through brain endothelium. Archives of Neurology. 59: 391-7. PMID 11890842  0.56
2001 Biernacki K, Prat A, Blain M, Antel JP. Regulation of Th1 and Th2 lymphocyte migration by human adult brain endothelial cells Journal of Neuropathology and Experimental Neurology. 60: 1127-1136. PMID 11764086  0.8
2001 Pouly S, Prat A, Blain M, Olivier A, Antel J. NG2 immunoreactivity on human brain endothelial cells Acta Neuropathologica. 102: 313-320. PMID 11603805  0.8
2001 Prat A, Biernacki K, Wosik K, Antel JP. Glial cell influence on the human blood-brain barrier Glia. 36: 145-155. PMID 11596123 DOI: 10.1002/glia.1104  0.8
2001 Calabresi PA, Prat A, Biernacki K, Rollins J, Antel JP. T lymphocytes conditioned with Interferon beta induce membrane and soluble VCAM on human brain endothelial cells. Journal of Neuroimmunology. 115: 161-7. PMID 11282166 DOI: 10.1016/S0165-5728(01)00253-3  0.8
2000 Qin Y, Zhang DQ, Prat A, Pouly S, Antel J. Characterization of T cell lines derived from glatiramer-acetate-treated multiple sclerosis patients Journal of Neuroimmunology. 108: 201-206. PMID 10900354 DOI: 10.1016/S0165-5728(00)00263-0  0.8
2000 Antel J, Prat A. Antigen and superantigen presentation in the human CNS Journal of Neuroimmunology. 107: 118-123. PMID 10854645 DOI: 10.1016/S0165-5728(00)00229-0  0.8
2000 Prat A, Biernacki K, Becher B, Antel JP. B7 expression and antigen presentation by human brain endothelial cells: Requirement for proinflammatory cytokines Journal of Neuropathology and Experimental Neurology. 59: 129-136. PMID 10749102  0.8
2000 Prat A, Pelletier D, Duquette P, Arnold DL, Antel JP. Heterogeneity of T-lymphocyte function in primary progressive multiple sclerosis: Relation to magnetic resonance imaging lesion volume Annals of Neurology. 47: 234-237. PMID 10665495 DOI: 10.1002/1531-8249(200002)47:2<234::AID-ANA14>3.0.CO;2-S  0.8
2000 Becher B, Prat A, Antel JP. Brain-immune connection: Immuno-regulatory properties of CNS-resident cells Glia. 29: 293-304. PMID 10652440 DOI: 10.1002/(SICI)1098-1136(20000215)29:4<293::AID-GLIA1>3.0.CO;2-A  0.8
1999 Prat A, Al-Asmi A, Duquette P, Antel JP. Lymphocyte migration and multiple sclerosis: Relation with disease course and therapy Annals of Neurology. 46: 253-256. PMID 10443892 DOI: 10.1002/1531-8249(199908)46:2<253::AID-ANA16>3.0.CO;2-C  0.8
1995 Couture R, Picard P, Poulat P, Prat A. Characterization of the tachykinin receptors involved in spinal and supraspinal cardiovascular regulation Canadian Journal of Physiology and Pharmacology. 73: 892-902. PMID 8846427  0.8
1994 Prat A, Picard P, Couture R. Cardiovascular and behavioural effects of centrally administered neuropeptide K in the rat: Receptor characterization British Journal of Pharmacology. 112: 250-256. PMID 7518305  0.8
1993 Prat A, Picard P, Domenico R, Couture R. Characterization of the cardiovascular and behavioral effects of centrally administered neuropeptide K in the conscious rat Regulatory Peptides. 46: 317-320. PMID 8210496 DOI: 10.1016/0167-0115(93)90072-G  0.8
1993 Prat A, Hasséssian H, Couture R. Neuropeptide K potently stimulates the hydrolysis of phosphatidylinositol in the rat spinal cord Neuroscience Letters. 159: 95-98. PMID 7505418 DOI: 10.1016/0304-3940(93)90807-W  0.8
1992 Hasséssian H, Prat A, Couture R. Anaesthetic doses of pentobarbital antagonize phosphatidylinositol hydrolysis induced by substance P or carbachol in the spinal cord and cerebral cortex of the rat European Journal of Pharmacology: Molecular Pharmacology. 227: 103-107. PMID 1385186 DOI: 10.1016/0922-4106(92)90150-T  0.8
1991 Hasséssian H, Prat A, De Champlain J, Couture R. Regulation of cardiovascular sympathetic neurons by substance P and γ-aminobutyric acid in the rat spinal cord European Journal of Pharmacology. 202: 51-60. PMID 1723952 DOI: 10.1016/0014-2999(91)90252-L  0.8
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