| Year |
Citation |
Score |
| 2024 |
Camara A, Chugh H, George A, Dolidze L, Ryu K, Holly KJ, Flaherty DP, Mattoo S. Discovery and Validation of a Novel Inhibitor of HYPE-mediated AMPylation. Cell Stress & Chaperones. PMID 38599565 DOI: 10.1016/j.cstres.2024.04.001 |
0.329 |
|
| 2023 |
Imhoff RD, Rosenthal MR, Ashraf K, Bhanot P, Ng CL, Flaherty DP. Identification of covalent fragment inhibitors for Plasmodium falciparum UCHL3 with anti-malarial efficacy. Bioorganic & Medicinal Chemistry Letters. 94: 129458. PMID 37634761 DOI: 10.1016/j.bmcl.2023.129458 |
0.309 |
|
| 2022 |
Dwyer TS, O'Brien JB, Ptak CP, LaVigne JE, Flaherty DP, Watts VJ, Roman DL. Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype. Frontiers in Pharmacology. 13: 977742. PMID 36147328 DOI: 10.3389/fphar.2022.977742 |
0.33 |
|
| 2021 |
Chojnacki M, Cao X, Flaherty DP, Dunman PM. Optimization of 2-Acylaminocycloalkylthiophene Derivatives for Activity against RnpA. Antibiotics (Basel, Switzerland). 10. PMID 33807357 DOI: 10.3390/antibiotics10040369 |
0.373 |
|
| 2021 |
Krabill AD, Chen H, Hussain S, Hewitt CS, Imhoff RD, Muli CS, Das C, Galardy PJ, Wendt MK, Flaherty DP. Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1. Molecules (Basel, Switzerland). 26. PMID 33668938 DOI: 10.3390/molecules26051227 |
0.382 |
|
| 2019 |
Colquhoun JM, Ha L, Beckley A, Meyers B, Flaherty DP, Dunman PM. Identification of Small Molecule Inhibitors of RnpA. Antibiotics (Basel, Switzerland). 8. PMID 31035380 DOI: 10.3390/Antibiotics8020048 |
0.36 |
|
| 2017 |
Flaherty DP, Harris MT, Schroeder CE, Khan H, Kahney E, Hackler A, Patrick S, Weiner WS, Aube J, Sharlow ER, Morris JC, Golden JE. Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1. Chemmedchem. PMID 29105342 DOI: 10.1002/Cmdc.201700592 |
0.645 |
|
| 2017 |
Hackler A, Patrick SL, Kahney EW, Flaherty DP, Sharlow ER, Morris JC, Golden JE. Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids. Bioorganic & Medicinal Chemistry Letters. PMID 28119024 DOI: 10.1016/J.Bmcl.2017.01.043 |
0.645 |
|
| 2016 |
Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden JE, Contessa JN. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nature Chemical Biology. PMID 27694802 DOI: 10.1038/Nchembio.2194 |
0.624 |
|
| 2014 |
Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Vasile S, Salaniwal S, Su Y, Smith LH, Chung TD, Pinkerton AB, Aubé J, et al. Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response. Acs Medicinal Chemistry Letters. 5: 1278-1283. PMID 25530830 DOI: 10.1021/Ml5003234 |
0.631 |
|
| 2014 |
Matharu DS, Flaherty DP, Simpson DS, Schroeder CE, Chung D, Yan D, Noah JW, Jonsson CB, White EL, Aubé J, Plemper RK, Severson WE, Golden JE. Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity. Journal of Medicinal Chemistry. 57: 10314-28. PMID 25399509 DOI: 10.1021/Jm500902X |
0.584 |
|
| 2014 |
Flaherty DP, Simpson DS, Miller M, Maki BE, Zou B, Shi J, Wu M, McManus OB, Aubé J, Li M, Golden JE. Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorganic & Medicinal Chemistry Letters. 24: 3968-73. PMID 25017033 DOI: 10.1016/J.Bmcl.2014.06.032 |
0.577 |
|
| 2013 |
Harris MT, Walker DM, Drew ME, Mitchell WG, Dao K, Schroeder CE, Flaherty DP, Weiner WS, Golden JE, Morris JC. Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase. Antimicrobial Agents and Chemotherapy. 57: 3731-7. PMID 23716053 DOI: 10.1128/Aac.00662-13 |
0.627 |
|
| 2010 |
Flaherty DP, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers. Journal of Medicinal Chemistry. 53: 7992-9. PMID 21038854 DOI: 10.1021/Jm1006929 |
0.494 |
|
| 2007 |
Flaherty DP, Walsh SM, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands. Journal of Medicinal Chemistry. 50: 4986-92. PMID 17845017 DOI: 10.1021/Jm070085F |
0.477 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2024 |
Imhoff RD, Patel R, Safdar MH, Jones HBL, Pinto-Fernandez A, Vendrell I, Chen H, Muli CS, Krabill AD, Kessler BM, Wendt MK, Das C, Flaherty DP. Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1. Journal of Medicinal Chemistry. PMID 38488146 DOI: 10.1021/acs.jmedchem.3c01661 |
0.282 |
|
| 2021 |
Nocentini A, Hewitt CS, Mastrolorenzo MD, Flaherty DP, Supuran CT. Anion inhibition studies of the α-carbonic anhydrases from . Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 1061-1066. PMID 34030562 DOI: 10.1080/14756366.2021.1929202 |
0.279 |
|
| 2020 |
Hewitt CS, Krabill AD, Das C, Flaherty DP. Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases. Biochemistry. PMID 32865982 DOI: 10.1021/Acs.Biochem.9B01076 |
0.274 |
|
| 2021 |
Hewitt CS, Abutaleb NS, Elhassanny AEM, Nocentini A, Cao X, Amos DP, Youse MS, Holly KJ, Marapaka AK, An W, Kaur J, Krabill AD, Elkashif A, Elgammal Y, Graboski AL, ... ... Flaherty DP, et al. Structure-Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against . Acs Infectious Diseases. PMID 33765392 DOI: 10.1021/acsinfecdis.1c00055 |
0.272 |
|
| 2022 |
Hewitt CS, Das C, Flaherty DP. Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3. Biomolecules. 12. PMID 35053210 DOI: 10.3390/biom12010062 |
0.268 |
|
| 2022 |
Scott JA, Soto-Velasquez M, Hayes MP, LaVigne JE, Miller HR, Kaur J, Ejendal KFK, Watts VJ, Flaherty DP. Optimization of a Pyrimidinone Series for Selective Inhibition of Ca/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain. Journal of Medicinal Chemistry. PMID 35271288 DOI: 10.1021/acs.jmedchem.1c01759 |
0.237 |
|
| 2022 |
Giovannuzzi S, Abutaleb NS, Hewitt CS, Carta F, Nocentini A, Seleem MN, Flaherty DP, Supuran CT. Dithiocarbamates effectively inhibit the α-carbonic anhydrase from . Journal of Enzyme Inhibition and Medicinal Chemistry. 37: 1-8. PMID 34894954 DOI: 10.1080/14756366.2021.1988945 |
0.234 |
|
| 2023 |
Graboski AL, Kowalewski ME, Simpson JB, Cao X, Ha M, Zhang J, Walton WG, Flaherty DP, Redinbo MR. Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate. Cell Chemical Biology. PMID 37633277 DOI: 10.1016/j.chembiol.2023.07.015 |
0.233 |
|
| 2022 |
Abutaleb NS, Elhassanny AEM, Nocentini A, Hewitt CS, Elkashif A, Cooper BR, Supuran CT, Seleem MN, Flaherty DP. Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of . Journal of Enzyme Inhibition and Medicinal Chemistry. 37: 51-61. PMID 34894972 DOI: 10.1080/14756366.2021.1991336 |
0.225 |
|
| 2022 |
Giovannuzzi S, Hewitt CS, Nocentini A, Capasso C, Flaherty DP, Supuran CT. Coumarins effectively inhibit bacterial α-carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry. 37: 333-338. PMID 34979838 DOI: 10.1080/14756366.2021.2012174 |
0.224 |
|
| 2019 |
Krabill AD, Chen H, Hussain S, Feng C, Abdullah A, Das C, Aryal UK, Post CB, Wendt MK, Galardy PJ, Flaherty DP. Biochemical and cellular characterization of a cyanopyrrolidine covalent Ubiquitin C-terminal hydrolase L1 inhibitor. Chembiochem : a European Journal of Chemical Biology. PMID 31449350 DOI: 10.1002/Cbic.201900434 |
0.22 |
|
| 2014 |
Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP. Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus. Journal of Medicinal Chemistry. 57: 8540-62. PMID 25238555 DOI: 10.1021/Jm5010682 |
0.215 |
|
| 2024 |
Chandra Jena B, Flaherty DP, O'Brien VP, Watts VJ. Biochemical pharmacology of adenylyl cyclases in cancer. Biochemical Pharmacology. 116160. PMID 38522554 DOI: 10.1016/j.bcp.2024.116160 |
0.197 |
|
| 2021 |
Abutaleb NS, Elhassanny AEM, Flaherty DP, Seleem MN. In vitro and in vivo activities of the carbonic anhydrase inhibitor, dorzolamide, against vancomycin-resistant enterococci. Peerj. 9: e11059. PMID 33850651 DOI: 10.7717/peerj.11059 |
0.194 |
|
| 2023 |
Giovannuzzi S, Marapaka AK, Abutaleb NS, Carta F, Liang HW, Nocentini A, Pisano L, Seleem MN, Flaherty DP, Supuran CT. Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates. Journal of Enzyme Inhibition and Medicinal Chemistry. 38: 2284119. PMID 37994421 DOI: 10.1080/14756366.2023.2284119 |
0.191 |
|
| 2022 |
Giovannuzzi S, Hewitt CS, Nocentini A, Capasso C, Costantino G, Flaherty DP, Supuran CT. Inhibition studies of bacterial α-carbonic anhydrases with phenols. Journal of Enzyme Inhibition and Medicinal Chemistry. 37: 666-671. PMID 35139743 DOI: 10.1080/14756366.2022.2038592 |
0.18 |
|
| 2020 |
Kaur J, Cao X, Abutaleb NS, Elkashif A, Graboski AL, Krabill AD, AbdelKhalek AH, An W, Bhardwaj A, Seleem MN, Flaherty DP. Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant . Journal of Medicinal Chemistry. PMID 32787141 DOI: 10.1021/acs.jmedchem.0c00734 |
0.179 |
|
| 2018 |
Ha L, Colquhoun J, Noinaj N, Das C, Dunman PM, Flaherty DP. Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus. Acta Crystallographica. Section F, Structural Biology Communications. 74: 632-637. PMID 30279314 DOI: 10.1107/S2053230X18011512 |
0.175 |
|
| 2024 |
Kenny S, Lai CH, Chiang TS, Brown K, Hewitt CS, Krabill AD, Chang HT, Wang YS, Flaherty DP, Danny Hsu ST, Das C. Altered protein dynamics and a more reactive catalytic cysteine in a neurodegeneration-associated UCHL1 mutant. Journal of Molecular Biology. 168438. PMID 38185323 DOI: 10.1016/j.jmb.2024.168438 |
0.174 |
|
| 2018 |
Kaur J, Soto-Velasquez M, Ding Z, Ghanbarpour A, Lill MA, van Rijn RM, Watts VJ, Flaherty DP. Optimization of a 1,3,4-oxadiazole series for inhibition of Ca/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain. European Journal of Medicinal Chemistry. 162: 568-585. PMID 30472604 DOI: 10.1016/J.Ejmech.2018.11.036 |
0.173 |
|
| 2023 |
Abutaleb NS, Shrinidhi A, Bandara AB, Seleem MN, Flaherty DP. Evaluation of 1,3,4-Thiadiazole Carbonic Anhydrase Inhibitors for Gut Decolonization of Vancomycin-Resistant Enterococci. Acs Medicinal Chemistry Letters. 14: 487-492. PMID 37077393 DOI: 10.1021/acsmedchemlett.3c00032 |
0.169 |
|
| 2020 |
Krabill AD, Chen H, Hussain S, Feng C, Abdullah A, Hewitt CS, Das C, Aryal UK, Post CB, Wendt MK, Galardy PJ, Flaherty DP. Corrigendum: Ubiquitin C-Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine-Based Inhibitor. Chembiochem : a European Journal of Chemical Biology. 21: 2701. PMID 32931129 DOI: 10.1002/cbic.202000493 |
0.168 |
|
| 2020 |
Chojnacki M, Cao X, Young M, Fritz RN, Dunman PM, Flaherty DP. Optimization of sulfonamide scaffold to reverse Acinetobacter baumannii serum-adaptive efflux associated antibiotic tolerance. Chemmedchem. PMID 32681604 DOI: 10.1002/Cmdc.202000328 |
0.158 |
|
| 2021 |
Sheedlo MJ, Kenny S, Podkorytov IS, Brown K, Ma J, Iyer S, Hewitt CS, Arbough T, Mikhailovskii O, Flaherty DP, Wilson MA, Skrynnikov NR, Das C. Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA. Biochemistry. PMID 33583181 DOI: 10.1021/acs.biochem.0c00760 |
0.152 |
|
| 2022 |
Marapaka AK, Nocentini A, Youse MS, An W, Holly KJ, Das C, Yadav R, Seleem MN, Supuran CT, Flaherty DP. Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to α-Carbonic Anhydrase. Acs Medicinal Chemistry Letters. 14: 103-109. PMID 36655133 DOI: 10.1021/acsmedchemlett.2c00471 |
0.148 |
|
| 2019 |
Wang K, Flaherty DP, Chen L, Yang D. High-Throughput Screening of G-Quadruplex Ligands by FRET Assay. Methods in Molecular Biology (Clifton, N.J.). 2035: 323-331. PMID 31444759 DOI: 10.1007/978-1-4939-9666-7_19 |
0.146 |
|
| 2022 |
An W, Holly KJ, Nocentini A, Imhoff RD, Hewitt CS, Abutaleb NS, Cao X, Seleem MN, Supuran CT, Flaherty DP. Structure-activity relationship studies for inhibitors for vancomycin-resistant and human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry. 37: 1838-1844. PMID 35758212 DOI: 10.1080/14756366.2022.2092729 |
0.139 |
|
| 2023 |
Young M, Chojnacki M, Blanchard C, Cao X, Johnson WL, Flaherty D, Dunman PM. Genetic Determinants of Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance. Antibiotics (Basel, Switzerland). 12. PMID 37508269 DOI: 10.3390/antibiotics12071173 |
0.124 |
|
| 2024 |
Tang H, Gupta A, Morrisroe SA, Bao C, Schwantes-An TH, Gupta G, Liang S, Sun Y, Chu A, Luo A, Ramamoorthi Elangovan V, Sangam S, Shi Y, Naidu SR, Jheng JR, ... ... Flaherty DP, et al. Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension. Circulation. PMID 38695173 DOI: 10.1161/CIRCULATIONAHA.123.065304 |
0.096 |
|
| 2021 |
Abutaleb NS, Elkashif A, Flaherty DP, Seleem MN. antibacterial activity of acetazolamide. Antimicrobial Agents and Chemotherapy. PMID 33495225 DOI: 10.1128/AAC.01715-20 |
0.095 |
|
| 2024 |
Nguyen BV, Özden C, Dong K, Torres-Ocampo AP, Dziedzic N, Flaherty D, Huang J, Sankura S, Abromson NL, Tomchick DR, Chen J, Garman SC, Stratton MM. A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation. Biorxiv : the Preprint Server For Biology. PMID 38585726 DOI: 10.1101/2024.03.24.586494 |
0.084 |
|
| 2023 |
Chilambi GS, Wang YH, Wallace NR, Obiwuma C, Evans KM, Li Y, Shalaby MW, Flaherty DP, Shields RK, Doi Y, Van Tyne D. Carbonic Anhydrase Inhibition as a Target for Antibiotic Synergy in Enterococci. Microbiology Spectrum. e0396322. PMID 37260400 DOI: 10.1128/spectrum.03963-22 |
0.084 |
|
| 2021 |
Flaherty DP, Seleem MN, Supuran CT. Bacterial carbonic anhydrases: underexploited antibacterial therapeutic targets. Future Medicinal Chemistry. PMID 34382415 DOI: 10.4155/fmc-2021-0207 |
0.079 |
|
| 2020 |
Saboo S, Kestur US, Flaherty DP, Taylor LS. Congruent release of drug and polymer from amorphous solid dispersions: insights into the role of drug-polymer hydrogen bonding, surface crystallization and glass transition. Molecular Pharmaceutics. PMID 32134677 DOI: 10.1021/Acs.Molpharmaceut.9B01272 |
0.057 |
|
| Hide low-probability matches. |