| Year |
Citation |
Score |
| 2024 |
Alasady MJ, Koeva M, Takagishi SR, Segal D, Amici DR, Smith RS, Ansel DJ, Lindquist S, Whitesell L, Bartom ET, Taipale M, Mendillo ML. An HSF1-JMJD6-HSP feedback circuit promotes cell adaptation to proteotoxic stress. Proceedings of the National Academy of Sciences of the United States of America. 121: e2313370121. PMID 38985769 DOI: 10.1073/pnas.2313370121 |
0.341 |
|
| 2022 |
Smith RS, Takagishi SR, Amici DR, Metz K, Gayatri S, Alasady MJ, Wu Y, Brockway S, Taiberg SL, Khalatyan N, Taipale M, Santagata S, Whitesell L, Lindquist S, Savas JN, et al. HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state. Science Advances. 8: eabj6526. PMID 35294249 DOI: 10.1126/sciadv.abj6526 |
0.315 |
|
| 2021 |
Nishida Y, Zhao R, Heese LE, Akiyama H, Patel S, Jaeger AM, Jacamo RO, Kojima K, Ma MCJ, Ruvolo VR, Chachad D, Devine W, Lindquist S, Davis RE, Porco JA, ... Whitesell L, et al. Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML. Leukemia. PMID 34127794 DOI: 10.1038/s41375-021-01308-z |
0.334 |
|
| 2021 |
Marcyk PT, LeBlanc EV, Kuntz DA, Xue A, Ortiz F, Trilles R, Bengtson S, Kenney TMG, Huang DS, Robbins N, Williams NS, Krysan DJ, Privé GG, Whitesell L, Cowen LE, et al. Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity. Journal of Medicinal Chemistry. PMID 33444025 DOI: 10.1021/acs.jmedchem.0c01777 |
0.325 |
|
| 2019 |
Jaeger AM, Whitesell L. HSP90: Enabler of Cancer Adaptation Annual Review of Cancer Biology. 3: 275-297. DOI: 10.1146/ANNUREV-CANCERBIO-030518-055533 |
0.39 |
|
| 2018 |
Neckers L, Blagg B, Haystead T, Trepel JB, Whitesell L, Picard D. Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development. Cell Stress & Chaperones. PMID 29392504 DOI: 10.1007/S12192-018-0877-2 |
0.333 |
|
| 2016 |
Scherz-Shouval R, Mendillo ML, Gaglia G, Ben-Aharon I, Beck AH, Whitesell L, Lindquist S. Abstract PR07: Mechanisms of stromal reprogramming mediated by heat shock factor 1 Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-Pr07 |
0.327 |
|
| 2015 |
Ishizawa J, Jacamo RO, Kojima K, Chachad D, Ruvolo V, Ruvolo P, Zang W, Tabe Y, Konopleva M, Devine W, Lindquist S, Porco JA, Whitesell L, Andreeff M. Inactivating Heat Shock Factor 1 (HSF1) in Acute Myeloid Leukemia By Pharmacological Inhibition of eIF4a: A Promising Therapeutic Approach Blood. 126: 2548-2548. DOI: 10.1182/Blood.V126.23.2548.2548 |
0.321 |
|
| 2015 |
Wang VS, Kyin NN, Pollock C, Lee H, Li X, Prandi C, Kapulnik Y, Koltai H, Whitesell L, Yarden R. Abstract 1777: The characterization of the effects of the strigolactones on the heat shock response Cancer Research. 75: 1777-1777. DOI: 10.1158/1538-7445.Am2015-1777 |
0.373 |
|
| 2014 |
Whitesell L, Santagata S, Mendillo ML, Lin NU, Proia DA, Lindquist S. HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models. Proceedings of the National Academy of Sciences of the United States of America. 111: 18297-302. PMID 25489079 DOI: 10.1073/Pnas.1421323111 |
0.363 |
|
| 2013 |
Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA, Whitesell L, Lindquist S. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (New York, N.Y.). 341: 1238303. PMID 23869022 DOI: 10.1126/Science.1238303 |
0.313 |
|
| 2013 |
Gunaherath GMKB, Marron MT, Wijeratne EMK, Whitesell L, Gunatilaka AAL. Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors Bioorganic and Medicinal Chemistry. 21: 5118-5129. PMID 23859777 DOI: 10.1016/J.Bmc.2013.06.042 |
0.35 |
|
| 2013 |
Taipale M, Krykbaeva I, Whitesell L, Santagata S, Zhang J, Liu Q, Gray NS, Lindquist S. Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. Nature Biotechnology. 31: 630-7. PMID 23811600 DOI: 10.1038/Nbt.2620 |
0.374 |
|
| 2013 |
Scherz-Shouval R, Santagata S, Koeva M, Whitesell L, Lindquist S. Abstract A23: Cell autonomous and nonautonomous activities of heat shock factor 1 support tumor initiation, progression, and metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A23 |
0.353 |
|
| 2013 |
Scherz-Shouval R, Bagley AF, Whitesell L, Bhatia SN, Lindquist S. Abstract C132: Targeting heat shock factor 1 improves the antitumor efficiency of hyperthermia. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C132 |
0.396 |
|
| 2012 |
Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S. HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell. 150: 549-62. PMID 22863008 DOI: 10.1016/J.Cell.2012.06.031 |
0.328 |
|
| 2012 |
Whitesell L, Santagata S, Lin NU. Inhibiting HSP90 to treat cancer: a strategy in evolution. Current Molecular Medicine. 12: 1108-24. PMID 22804235 DOI: 10.2174/156652412803306657 |
0.354 |
|
| 2012 |
Santagata S, Xu YM, Wijeratne EM, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AA. Using the heat-shock response to discover anticancer compounds that target protein homeostasis. Acs Chemical Biology. 7: 340-9. PMID 22050377 DOI: 10.1021/Cb200353M |
0.454 |
|
| 2011 |
Whitesell L, Lin NU. HSP90 as a platform for the assembly of more effective cancer chemotherapy. Biochimica Et Biophysica Acta. 1823: 756-66. PMID 22222203 DOI: 10.1016/j.bbamcr.2011.12.006 |
0.362 |
|
| 2011 |
Mendillo M, Santagata S, Koeva M, Fraenkel E, Ince T, Whitesell L, Lindquist S. P3-01-09: Oncogenic Activation of HSF1 Enables the Malignant Progression of Breast Carcinoma. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P3-01-09 |
0.349 |
|
| 2010 |
Lin N, Beliakoff J, Foley K, Whitesell L, Lindquist S. Abstract P6-15-06: Heat Shock Protein 90 Inhibition Limits the Emergence of Tamoxifen Resistance Cancer Research. 70. DOI: 10.1158/0008-5472.Sabcs10-P6-15-06 |
0.522 |
|
| 2009 |
Whitesell L, Lindquist S. Inhibiting the transcription factor HSF1 as an anticancer strategy Expert Opinion On Therapeutic Targets. 13: 469-478. PMID 19335068 DOI: 10.1517/14728220902832697 |
0.339 |
|
| 2008 |
Hargreaves RH, David CL, Whitesell LJ, Labarbera DV, Jamil A, Chapuis JC, Skibo EB. Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition. Journal of Medicinal Chemistry. 51: 2492-501. PMID 18363347 DOI: 10.1021/Jm7014099 |
0.336 |
|
| 2007 |
McLellan CA, Turbyville TJ, Wijeratne EM, Kerschen A, Vierling E, Queitsch C, Whitesell L, Gunatilaka AA. A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitor. Plant Physiology. 145: 174-82. PMID 17631526 DOI: 10.1104/Pp.107.101808 |
0.696 |
|
| 2006 |
Wijeratne EM, Turbyville TJ, Fritz A, Whitesell L, Gunatilaka AA. A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity. Bioorganic & Medicinal Chemistry. 14: 7917-23. PMID 16904330 DOI: 10.1016/J.Bmc.2006.07.048 |
0.665 |
|
| 2006 |
Cullinan SB, Whitesell L. Heat shock protein 90: a unique chemotherapeutic target. Seminars in Oncology. 33: 457-65. PMID 16890800 DOI: 10.1053/J.Seminoncol.2006.04.001 |
0.497 |
|
| 2006 |
Dai C, Whitesell L. HSP90: a rising star on the horizon of anticancer targets. Future Oncology (London, England). 1: 529-40. PMID 16556029 DOI: 10.2217/14796694.1.4.529 |
0.384 |
|
| 2006 |
Turbyville TJ, Wijeratne EM, Liu MX, Burns AM, Seliga CJ, Luevano LA, David CL, Faeth SH, Whitesell L, Gunatilaka AA. Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert. Journal of Natural Products. 69: 178-84. PMID 16499313 DOI: 10.1021/Np058095B |
0.728 |
|
| 2006 |
Falsey RR, Marron MT, Gunaherath GM, Shirahatti N, Mahadevan D, Gunatilaka AA, Whitesell L. Actin microfilament aggregation induced by withaferin A is mediated by annexin II. Nature Chemical Biology. 2: 33-8. PMID 16408090 DOI: 10.1038/Nchembio755 |
0.722 |
|
| 2005 |
Jeffy BD, Hockings JK, Kemp MQ, Morgan SS, Hager JA, Beliakoff J, Whitesell LJ, Bowden GT, Romagnolo DF. An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription. Neoplasia (New York, N.Y.). 7: 873-82. PMID 16229810 DOI: 10.1593/Neo.05256 |
0.728 |
|
| 2005 |
Turbyville TJ, Wijeratne EM, Whitesell L, Gunatilaka AA. The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways. Molecular Cancer Therapeutics. 4: 1569-76. PMID 16227407 DOI: 10.1158/1535-7163.Mct-05-0050 |
0.721 |
|
| 2005 |
Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nature Reviews. Cancer. 5: 761-72. PMID 16175177 DOI: 10.1038/nrc1716 |
0.358 |
|
| 2005 |
Devaney E, O'neill K, Harnett W, Whitesell L, Kinnaird JH. Hsp90 is essential in the filarial nematode Brugia pahangi. International Journal For Parasitology. 35: 627-36. PMID 15862576 DOI: 10.1016/J.Ijpara.2005.01.007 |
0.397 |
|
| 2005 |
Bagatell R, Beliakoff J, David CL, Marron MT, Whitesell L. Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin International Journal of Cancer. 113: 179-188. PMID 15455381 DOI: 10.1002/Ijc.20611 |
0.763 |
|
| 2005 |
Bagatell R, Whitesell L. Altered Hsp90 function in cancer: a unique therapeutic opportunity. Molecular Cancer Therapeutics. 3: 1021-30. PMID 15299085 |
0.402 |
|
| 2004 |
Wijeratne EM, Carbonezi CA, Takahashi JA, Seliga CJ, Turbyville TJ, Pierson EE, Pierson LS, VanEtten HD, Whitesell L, Bolzani Vda S, Gunatilaka AA. Isolation, optimization of production and structure-activity relationship studies of monocillin I, the cytotoxic constituent of Paraphaeosphaeria quadriseptata. The Journal of Antibiotics. 57: 541-6. PMID 15515894 DOI: 10.7164/Antibiotics.57.541 |
0.627 |
|
| 2004 |
Beliakoff J, Whitesell L. Hsp90: an emerging target for breast cancer therapy. Anti-Cancer Drugs. 15: 651-662. PMID 15269596 DOI: 10.1097/01.Cad.0000136876.11928.Be |
0.772 |
|
| 2004 |
Meade-Tollin LC, Wijeratne EMK, Cooper D, Guild M, Jon E, Fritz A, Zhou GX, Whitesell L, Liang JY, Gunatilaka AAL. Ponicidin and Oridonin Are Responsible for the Antiangiogenic Activity of Rabdosia rubescens, a Constituent of the Herbal Supplement PC SPES Journal of Natural Products. 67: 2-4. PMID 14738375 DOI: 10.1021/Np0304114 |
0.309 |
|
| 2004 |
Beliakoff J, Bagatell R, Paine-Murrieta G, Taylor CW, Lykkesfeldt AE, Whitesell L. Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 4961-71. PMID 14581371 |
0.766 |
|
| 2003 |
Wijeratne EM, Turbyville TJ, Zhang Z, Bigelow D, Pierson LS, VanEtten HD, Whitesell L, Canfield LM, Gunatilaka AA. Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran Desert. Journal of Natural Products. 66: 1567-73. PMID 14695798 DOI: 10.1021/Np030266U |
0.667 |
|
| 2003 |
Whitesell L, Bagatell R, Falsey R. The stress response: implications for the clinical development of hsp90 inhibitors. Current Cancer Drug Targets. 3: 349-358. PMID 14529386 DOI: 10.2174/1568009033481787 |
0.761 |
|
| 2003 |
David CL, Smith HE, Raynes DA, Pulcini EJ, Whitesell L. Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans. Cell Stress & Chaperones. 8: 93-104. PMID 12820659 DOI: 10.1379/1466-1268(2003)8<93:Eoaudh>2.0.Co;2 |
0.429 |
|
| 2003 |
Chiosis G, Huezo H, Rosen N, Mimnaugh E, Whitesell L, Neckers L. 17AAG: low target binding affinity and potent cell activity--finding an explanation. Molecular Cancer Therapeutics. 2: 123-9. PMID 12589029 |
0.314 |
|
| 2001 |
Feng H, Zeng Y, Whitesell L, Katsanis E. Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity. Blood. 97: 3505-12. PMID 11369644 DOI: 10.1182/Blood.V97.11.3505 |
0.414 |
|
| 2000 |
Yorgin PD, Hartson SD, Fellah AM, Scroggins BT, Huang W, Katsanis E, Couchman JM, Matts RL, Whitesell L. Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases. Journal of Immunology (Baltimore, Md. : 1950). 164: 2915-23. PMID 10706677 DOI: 10.4049/Jimmunol.164.6.2915 |
0.389 |
|
| 1999 |
Lele Z, Hartson SD, Martin CC, Whitesell L, Matts RL, Krone PH. Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90 Developmental Biology. 210: 56-70. PMID 10364427 DOI: 10.1006/Dbio.1999.9262 |
0.348 |
|
| 1999 |
Hartson SD, Thulasiraman V, Huang W, Whitesell L, Matts RL. Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates. Biochemistry. 38: 3837-49. PMID 10090774 DOI: 10.1021/Bi983027S |
0.407 |
|
| 1998 |
Whitesell L, Sutphin PD, Pulcini EJ, Martinez JD, Cook PH. The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. Molecular and Cellular Biology. 18: 1517-24. PMID 9488468 DOI: 10.1128/Mcb.18.3.1517 |
0.423 |
|
| 1998 |
Hartson SD, Yorgin PD, Whitesell LJ. GELDANAMYCIN DISRUPTS THE P56LCK-HEAT SHOCK PROTEIN-90 COMPLEX IN T-CELLS. Transplantation. 65: 209. DOI: 10.1097/00007890-199805131-00521 |
0.375 |
|
| 1997 |
Whitesell L, Sutphin P, An WG, Schulte T, Blagosklonny MV, Neckers L. Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo. Oncogene. 14: 2809-2816. PMID 9190897 DOI: 10.1038/Sj.Onc.1201120 |
0.359 |
|
| 1996 |
Whitesell L, Cook P. Stable and Specific Binding of Heat Shock Protein 90 by Geldanamycin Disrupts Glucocorticoid Receptor Function in Intact Cells Molecular Endocrinology. 10: 705-712. PMID 8776730 DOI: 10.1210/Mend.10.6.8776730 |
0.481 |
|
| 1996 |
Slepian MJ, Massia SP, Whitesell L. Pre-conditioning of smooth muscle cells via induction of the heat shock response limits proliferation following mechanical injury Biochemical and Biophysical Research Communications. 225: 600-607. PMID 8753806 DOI: 10.1006/Bbrc.1996.1217 |
0.359 |
|
| 1996 |
Chavany C, Mimnaugh E, Miller P, Bitton R, Nguyen P, Trepel J, Whitesell L, Schnur R, Moyer JD, Neckers L. p185 Binds to GRP94 in Vivo DISSOCIATION OF THE p185/GRP94 HETEROCOMPLEX BY BENZOQUINONE ANSAMYCINS PRECEDES DEPLETION OF p185 Journal of Biological Chemistry. 271: 4974-4977. PMID 8617772 DOI: 10.1074/Jbc.271.9.4974 |
0.34 |
|
| 1995 |
Mimnaugh EG, Worland PJ, Whitesell L, Neckers LM. Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase. Journal of Biological Chemistry. 270: 28654-28659. PMID 7499384 DOI: 10.1074/Jbc.270.48.28654 |
0.412 |
|
| 1994 |
Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proceedings of the National Academy of Sciences of the United States of America. 91: 8324-8. PMID 8078881 DOI: 10.1073/PNAS.91.18.8324 |
0.322 |
|
| 1992 |
Neckers LM, Rosolen A, Whitesell L. Antisense inhibition of gene expression: a tool for studying the role of NMYC in the growth and differentiation of neuroectoderm-derived cells. Journal of Immunotherapy. 12: 162-166. PMID 1332744 DOI: 10.1097/00002371-199210000-00003 |
0.345 |
|
| 1991 |
Whitesell L, Rosolen A, Neckers L. Episome-generated N-myc antisense RNA restricts the differentiation potential of primitive neuroectodermal cell lines. Molecular and Cellular Biology. 11: 1360-1371. PMID 1996098 DOI: 10.1128/Mcb.11.3.1360 |
0.305 |
|
| 1991 |
Whitesell L, Rosolen A, Neckers LM. In Vivo Modulation of N-myc Expression by Continuous Perfusion with an Antisense Oligonucleotide Antisense Research and Development. 1: 343-350. PMID 1821655 DOI: 10.1089/Ard.1991.1.343 |
0.323 |
|
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