Year |
Citation |
Score |
2021 |
Lewis AK, Harthorn A, Johnson SM, Lobb RR, Hackel BJ. Engineered protein-small molecule conjugates empower selective enzyme inhibition. Cell Chemical Biology. PMID 34363759 DOI: 10.1016/j.chembiol.2021.07.013 |
0.693 |
|
2018 |
Beaven AH, Romo TD, Lewis AK, Braun AR, Grossfield A, Sachs JN. Computational Studies of Alpha-Synuclein Fibril Formation and Stability Biophysical Journal. 114: 230a. DOI: 10.1016/J.Bpj.2017.11.1278 |
0.663 |
|
2017 |
Vunnam N, Campbell-Bezat CK, Lewis AK, Sachs JN. Death Receptor 5 Activation Is Energetically Coupled to Opening of the Transmembrane Domain Dimer. Biophysical Journal. 113: 381-392. PMID 28746849 DOI: 10.1016/J.Bpj.2017.05.038 |
0.692 |
|
2017 |
Romo TD, Lewis AK, Braun AR, Grossfield A, Sachs JN. Minimal nucleation state of alpha-Synuclein is stabilized by dynamic threonine-water networks. Acs Chemical Neuroscience. PMID 28677385 DOI: 10.1021/Acschemneuro.7B00171 |
0.703 |
|
2017 |
Lo CH, Vunnam N, Lewis AK, Chiu TL, Brummel BE, Schaaf TM, Grant BD, Bawaskar P, Thomas DD, Sachs JN. An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors. Slas Discovery. 2472555217706478. PMID 28530838 DOI: 10.1177/2472555217706478 |
0.697 |
|
2017 |
Valley CC, Lewis AK, Sachs JN. Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors. Biochimica Et Biophysica Acta. PMID 28089689 DOI: 10.1016/J.Bbamem.2017.01.016 |
0.806 |
|
2016 |
Lewis AK, Valley CC, Peery SL, Brummel B, Braun AR, Karim C, Sachs JN. Death Receptor 5 Networks Require Membrane Cholesterol for Proper Structure and Function. Journal of Molecular Biology. PMID 27720987 DOI: 10.1016/J.Jmb.2016.10.001 |
0.789 |
|
2016 |
Lewis AK, Dunleavy KM, Senkow TL, Her C, Horn BT, Jersett MA, Mahling R, McCarthy MR, Perell GT, Valley CC, Karim CB, Gao J, Pomerantz WC, Thomas DD, Cembran A, et al. Oxidation increases the strength of the methionine-aromatic interaction. Nature Chemical Biology. PMID 27547920 DOI: 10.1038/Nchembio.2159 |
0.766 |
|
2016 |
Hung Lo C, Lewis A, Schaaf T, Bawaskar P, Vunnam N, Peterson K, Thomas D, Sachs J. Manipulations of the TNF-Receptor Affinity and Oligomerization Characterized by Fluorescence Lifetime Measurements Biophysical Journal. 110: 490a. DOI: 10.1016/J.Bpj.2015.11.2618 |
0.718 |
|
2016 |
Senkow TL, Lewis AK, Sachs JN. Investigating the Role of Transmembrane Domain Cysteine Residues in the Organization of TNF Receptors Biophysical Journal. 110: 227a. DOI: 10.1016/J.Bpj.2015.11.1257 |
0.685 |
|
2015 |
Senkow TL, Lewis AK, McCarthy MR, Her C, Thomas DD, Sachs JN. Methionine-Aromatic Interactions in Calmodulin: A Replica Exchange MD and EPR Spectroscopy Study Biophysical Journal. 108: 213a-214a. DOI: 10.1016/J.Bpj.2014.11.1180 |
0.605 |
|
2014 |
Lewis AK, James ZM, McCaffrey JE, Braun AR, Karim CB, Thomas DD, Sachs JN. Open and closed conformations of the isolated transmembrane domain of death receptor 5 support a new model of activation. Biophysical Journal. 106: L21-4. PMID 24655519 DOI: 10.1016/J.Bpj.2014.01.044 |
0.78 |
|
2014 |
Lewis AK, Valley CC, Braun AR, Sachs JN. Quantitative Analysis of Ligand-Induced Supramolecular Clustering of Death Receptor 5 in Jurkat Cells Biophysical Journal. 106: 715a. DOI: 10.1016/J.Bpj.2013.11.3953 |
0.804 |
|
2014 |
Lewis AK, Sachs JN. Oxidative Stress Modulates Bioactivity of Lymphotoxin, but not TNF, Through Site-Specific Oxidation of Methionine Residues Biophysical Journal. 106: 251a-252a. DOI: 10.1016/J.Bpj.2013.11.1481 |
0.698 |
|
2012 |
Valley CC, Cembran A, Perlmutter JD, Lewis AK, Labello NP, Gao J, Sachs JN. The methionine-aromatic motif plays a unique role in stabilizing protein structure. The Journal of Biological Chemistry. 287: 34979-91. PMID 22859300 DOI: 10.1074/Jbc.M112.374504 |
0.77 |
|
2012 |
Lewis AK, Valley CC, Sachs JN. TNFR1 signaling is associated with backbone conformational changes of receptor dimers consistent with overactivation in the R92Q TRAPS mutant. Biochemistry. 51: 6545-55. PMID 22799488 DOI: 10.1021/Bi3006626 |
0.817 |
|
2012 |
Valley CC, Lewis AK, Mudaliar DJ, Perlmutter JD, Braun AR, Karim CB, Thomas DD, Brody JR, Sachs JN. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized. The Journal of Biological Chemistry. 287: 21265-78. PMID 22496450 DOI: 10.1074/Jbc.M111.306480 |
0.77 |
|
2012 |
Valley CC, Lewis AK, Mudaliar D, Sachs JN. Signaling in the Tumor Necrosis Factor Superfamily is Driven by Formation of Receptor Networks: Unraveling the Structural and Dynamic Paradigm Biophysical Journal. 102: 430a. DOI: 10.1016/J.Bpj.2011.11.2355 |
0.815 |
|
2012 |
Lewis AK. Analysis of Conformational Dynamics Associated with TNFR1 Signaling by Live-Cell FRET and Computational Modeling Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1381 |
0.538 |
|
Show low-probability matches. |