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Matthew G. Vander Heiden - Publications

Affiliations: 
 Biology  Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
cancer metabolism
Website:
https://biology.mit.edu/people/matthew_vander_heiden
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153 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Chen JK, Merrick KA, Kong YW, Izrael-Tomasevic A, Eng G, Handly ED, Patterson JC, Cannell IG, Suarez-Lopez L, Hosios AM, Dinh A, Kirkpatrick DS, Yu K, Rose CM, Hernandez JM, ... ... Vander Heiden MG, et al. An RNA damage response network mediates the lethality of 5-FU in colorectal cancer. Cell Reports. Medicine. 101778. PMID 39378883 DOI: 10.1016/j.xcrm.2024.101778  0.492
2024 Li Z, Munim MB, Sharygin DA, Bevis BJ, Vander Heiden MG. Understanding the Warburg Effect in Cancer. Cold Spring Harbor Perspectives in Medicine. PMID 39284669 DOI: 10.1101/cshperspect.a041532  0.43
2024 Tamir TY, Chaudhary S, Li AX, Trojan SE, Flower CT, Vo P, Cui Y, Davis JC, Mukkamala RS, Venditti FN, Hillis AL, Toker A, Vander Heiden MG, Spinelli JB, Kennedy NJ, et al. Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity. Biorxiv : the Preprint Server For Biology. PMID 39257804 DOI: 10.1101/2024.08.28.609894  0.586
2024 Sivanand S, Gultekin Y, Winter PS, Vermeulen SY, Tchourine KM, Abbott KL, Danai LV, Gourgue F, Do BT, Crowder K, Kunchok T, Lau AN, Darnell AM, Jefferson A, Morita S, ... ... Vander Heiden MG, et al. Cancer tissue of origin constrains the growth and metabolism of metastases. Nature Metabolism. PMID 39160333 DOI: 10.1038/s42255-024-01105-9  0.31
2024 Moon SJ, Chiappino-Pepe A, Dong W, Kelleher JK, Vander Heiden M, Stephanopoulos G, Sikes HD. NADPH composite index analysis quantifies the relationship between compartmentalized NADPH dynamics and growth rates in cancer cells. Biorxiv : the Preprint Server For Biology. PMID 38746234 DOI: 10.1101/2024.04.27.591477  0.321
2024 Dong T, Hu G, Fan Z, Wang H, Gao Y, Wang S, Xu H, Yaffe MB, Vander Heiden MG, Lv G, Chen J. Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis. Nature Communications. 15: 807. PMID 38280848 DOI: 10.1038/s41467-024-45167-5  0.462
2023 Diehl FF, Sapp KM, Vander Heiden MG. The bidirectional relationship between metabolism and cell cycle control. Trends in Cell Biology. PMID 37385879 DOI: 10.1016/j.tcb.2023.05.012  0.354
2023 Chen JK, Merrick KA, Kong YW, Izrael-Tomasevic A, Eng G, Handly ED, Patterson JC, Cannell IG, Suarez-Lopez L, Hosios AM, Dinh A, Kirkpatrick DS, Yu K, Rose CM, Hernandez JM, ... ... Vander Heiden MG, et al. An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types. Biorxiv : the Preprint Server For Biology. PMID 37162991 DOI: 10.1101/2023.04.28.538590  0.465
2023 Zhang H, Nabel CS, Li D, O'Connor RÍ, Crosby CR, Chang SM, Hao Y, Stanley R, Sahu S, Levin DS, Chen T, Tang S, Huang HY, Meynardie M, Stephens J, ... ... Vander Heiden MG, et al. Histone deacetylase 6 inhibition exploits selective metabolic vulnerabilities in LKB1 mutant, KRAS driven non-small cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 36958689 DOI: 10.1016/j.jtho.2023.03.014  0.302
2022 Do BT, Vander Heiden MG. GOT2 consider the tumor microenvironment. Trends in Cancer. PMID 36153305 DOI: 10.1016/j.trecan.2022.09.004  0.356
2022 Li Z, Ji BW, Dixit PD, Tchourine K, Lien EC, Hosios AM, Abbott KL, Rutter JC, Westermark AM, Gorodetsky EF, Sullivan LB, Vander Heiden MG, Vitkup D. Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited. Nature Metabolism. PMID 35739397 DOI: 10.1038/s42255-022-00588-8  0.322
2022 Davdison SM, Schmidt DR, Heyman JE, O'Brien JP, Liu AC, Israelsen WJ, Dayton TL, Sehgal R, Bronson RT, Freinkman E, Mak HH, Fanelli GN, Malstrom S, Bellinger G, Carracedo A, ... ... Vander Heiden MG, et al. Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma. Cancer Research. PMID 35584006 DOI: 10.1158/0008-5472.CAN-21-2352  0.696
2022 Gouirand V, Gicquel T, Lien EC, Jaune-Pons E, Da Costa Q, Finetti P, Metay E, Duluc C, Mayers JR, Audebert S, Camoin L, Borge L, Rubis M, Leca J, Nigri J, ... ... Vander Heiden MG, et al. Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression. The Embo Journal. e110466. PMID 35307861 DOI: 10.15252/embj.2021110466  0.393
2022 Chang SM, Vander Heiden MG. Inhibiting GLUTtony in cancer. Cell Chemical Biology. 29: 353-355. PMID 35303439 DOI: 10.1016/j.chembiol.2022.03.004  0.31
2022 Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Posada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, ... ... Vander Heiden MG, et al. Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis. Nature Cancer. 2: 1243. PMID 35122065 DOI: 10.1038/s43018-021-00283-9  0.581
2022 Datta R, Sivanand S, Lau AN, Florek LV, Barbeau AM, Wyckoff J, Skala MC, Vander Heiden MG. Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors. Science Advances. 8: eabg6383. PMID 35061540 DOI: 10.1126/sciadv.abg6383  0.36
2021 Sullivan MR, Darnell AM, Reilly MF, Kunchok T, Joesch-Cohen L, Rosenberg D, Ali A, Rees MG, Roth JA, Lewis CA, Vander Heiden MG. Methionine synthase is essential for cancer cell proliferation in physiological folate environments. Nature Metabolism. 3: 1500-1511. PMID 34799701 DOI: 10.1038/s42255-021-00486-5  0.337
2021 Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J. Editorial Note to: Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply. Molecular Cell. 81: 3031. PMID 34270944 DOI: 10.1016/j.molcel.2021.06.029  0.49
2021 Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, ... ... Vander Heiden MG, et al. FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS. Nature Cancer. 2: 414-428. PMID 34179825 DOI: 10.1038/s43018-021-00183-y  0.609
2021 Li Q, Li C, Elnwasany A, Sharma G, An YA, Zhang G, Elhelaly WM, Lin J, Gong Y, Chen G, Wang MH, Zhao S, Dai C, Smart CD, Liu J, ... ... Vander Heiden MG, et al. PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart. Circulation. PMID 34102853 DOI: 10.1161/CIRCULATIONAHA.121.054885  0.482
2021 Schmidt DR, Patel R, Kirsch DG, Lewis CA, Vander Heiden MG, Locasale JW. Metabolomics in cancer research and emerging applications in clinical oncology. Ca: a Cancer Journal For Clinicians. PMID 33982817 DOI: 10.3322/caac.21670  0.583
2021 Tian C, Huang Y, Clauser KR, Rickelt S, Lau AN, Carr SA, Vander Heiden MG, Hynes RO. Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells. Nature Communications. 12: 2328. PMID 33879793 DOI: 10.1038/s41467-021-22490-9  0.302
2021 Mukhopadhyay S, Vander Heiden MG, McCormick F. The Metabolic Landscape of RAS-Driven Cancers from biology to therapy. Nature Cancer. 2: 271-283. PMID 33870211 DOI: 10.1038/s43018-021-00184-x  0.302
2021 Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, ... ... Vander Heiden MG, et al. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature. PMID 33828302 DOI: 10.1038/s41586-021-03442-1  0.356
2021 Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, ... Vander Heiden MG, et al. Differential Substrate Use in EGF- and Oncogenic KRAS-Stimulated Human Mammary Epithelial Cells. The Febs Journal. PMID 33811729 DOI: 10.1111/febs.15858  0.388
2020 Jin X, Demere Z, Nair K, Ali A, Ferraro GB, Natoli T, Deik A, Petronio L, Tang AA, Zhu C, Wang L, Rosenberg D, Mangena V, Roth J, Chung K, ... ... Vander Heiden MG, et al. A metastasis map of human cancer cell lines. Nature. 588: 331-336. PMID 33299191 DOI: 10.1038/s41586-020-2969-2  0.318
2020 Kang JH, Katsikis G, Li Z, Sapp KM, Stockslager MA, Lim D, Vander Heiden MG, Yaffe MB, Manalis SR, Miettinen TP. Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division. Nature Communications. 11: 4983. PMID 33020492 DOI: 10.1038/s41467-020-18769-y  0.487
2020 Sivanand S, Vander Heiden MG. Transcriptional activation of macropinocytosis by the Hippo pathway following nutrient limitation. Genes & Development. 34: 1253-1255. PMID 33004484 DOI: 10.1101/gad.343632.120  0.371
2020 van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, et al. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metabolism. PMID 32763164 DOI: 10.1016/J.Cmet.2020.07.009  0.409
2020 Lau AN, Li Z, Danai LV, Westermark AM, Darnell AM, Ferreira R, Gocheva V, Sivanand S, Lien EC, Sapp KM, Mayers JR, Biffi G, Chin CR, Davidson SM, Tuveson DA, ... ... Vander Heiden MG, et al. Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma. Elife. 9. PMID 32648540 DOI: 10.7554/Elife.56782  0.417
2020 Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, ... ... Vander Heiden MG, et al. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer Discovery. PMID 32571778 DOI: 10.1158/2159-8290.Cd-19-1228  0.753
2020 Sivanand S, Vander Heiden MG. Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer. Cancer Cell. 37: 147-156. PMID 32049045 DOI: 10.1016/j.ccell.2019.12.011  0.339
2019 Luengo A, Abbott KL, Davidson SM, Hosios AM, Faubert B, Chan SH, Freinkman E, Zacharias LG, Mathews TP, Clish CB, DeBerardinis RJ, Lewis CA, Vander Heiden MG. Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer. Nature Communications. 10: 5604. PMID 31811141 DOI: 10.1038/S41467-019-13419-4  0.376
2019 Liu VM, Howell AJ, Hosios AM, Li Z, Israelsen WJ, Vander Heiden MG. Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity. Febs Letters. PMID 31642061 DOI: 10.1002/1873-3468.13648  0.302
2019 Diehl FF, Lewis CA, Fiske BP, Vander Heiden MG. Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation. Nature Metabolism. 1: 861-867. PMID 31598584 DOI: 10.1038/s42255-019-0108-x  0.373
2019 Lien EC, Vander Heiden MG. A framework for examining how diet impacts tumour metabolism. Nature Reviews. Cancer. PMID 31530936 DOI: 10.1038/s41568-019-0198-5  0.314
2019 Liu T, Kuwana T, Zhang H, Vander Heiden MG, Lerner RA, Newmeyer DD. Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1. Plos Biology. 17: e2004413. PMID 31181072 DOI: 10.1371/Journal.Pbio.2004413  0.344
2019 Sullivan MR, Vander Heiden MG. Determinants of nutrient limitation in cancer. Critical Reviews in Biochemistry and Molecular Biology. 1-15. PMID 31162937 DOI: 10.1080/10409238.2019.1611733  0.392
2019 Sullivan MR, Mattaini KR, Dennstedt EA, Nguyen AA, Sivanand S, Reilly MF, Meeth K, Muir A, Darnell AM, Bosenberg MW, Lewis CA, Vander Heiden MG. Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting. Cell Metabolism. PMID 30905671 DOI: 10.1016/j.cmet.2019.02.015  0.306
2018 McKenney AS, Lau AN, Somasundara AVH, Spitzer B, Intlekofer AM, Ahn J, Shank K, Rapaport FT, Patel MA, Papalexi E, Shih AH, Chiu A, Freinkman E, Akbay EA, Steadman M, ... ... Vander Heiden MG, et al. JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition. The Journal of Clinical Investigation. PMID 30222137 DOI: 10.1172/Jci124920  0.338
2018 Muir A, Danai LV, Vander Heiden MG. Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies. Disease Models & Mechanisms. 11. PMID 30104199 DOI: 10.1242/dmm.035758  0.421
2018 Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG. Aspartate is an endogenous metabolic limitation for tumour growth. Nature Cell Biology. PMID 29941931 DOI: 10.1038/S41556-018-0125-0  0.385
2018 Hosios AM, Vander Heiden MG. The redox requirements of proliferating mammalian cells. The Journal of Biological Chemistry. PMID 29339555 DOI: 10.1074/jbc.TM117.000239  0.317
2017 Lau AN, Israelsen WJ, Roper J, Sinnamon MJ, Georgeon L, Dayton TL, Hillis AL, Yilmaz OH, Di Vizio D, Hung KE, Vander Heiden MG. PKM2 is not required for colon cancer initiated by APC loss. Cancer & Metabolism. 5: 10. PMID 29214019 DOI: 10.1186/S40170-017-0172-1  0.352
2017 Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, ... ... Vander Heiden MG, et al. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. Nature Medicine. PMID 28967920 DOI: 10.1038/Nm.4407  0.454
2017 Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, ... ... Vander Heiden MG, et al. Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. Elife. 6. PMID 28967864 DOI: 10.7554/Elife.28083  0.402
2017 Luengo A, Gui DY, Vander Heiden MG. Targeting Metabolism for Cancer Therapy. Cell Chemical Biology. 24: 1161-1180. PMID 28938091 DOI: 10.1016/j.chembiol.2017.08.028  0.357
2017 Muir A, Danai LV, Gui DY, Waingarten CY, Lewis CA, Vander Heiden MG. Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition. Elife. 6. PMID 28826492 DOI: 10.7554/eLife.27713  0.31
2017 Olivares O, Mayers JR, Gouirand V, Torrence ME, Gicquel T, Borge L, Lac S, Roques J, Lavaut MN, Berthezène P, Rubis M, Secq V, Garcia S, Moutardier V, Lombardo D, ... ... Vander Heiden MG, et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nature Communications. 8: 16031. PMID 28685754 DOI: 10.1038/ncomms16031  0.359
2017 Mayers JR, Vander Heiden MG. Nature and Nurture: What Determines Tumor Metabolic Phenotypes? Cancer Research. PMID 28584183 DOI: 10.1158/0008-5472.CAN-17-0165  0.341
2017 Tech K, Tikunov AP, Farooq H, Morrissy AS, Meidinger J, Fish T, Green SC, Liu H, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJ, Marra MA, Vander Heiden MG, et al. Pyruvate kinase inhibits proliferation during postnatal cerebellar neurogenesis and suppresses medulloblastoma formation. Cancer Research. PMID 28515149 DOI: 10.1158/0008-5472.Can-16-3304  0.352
2017 Vander Heiden MG, DeBerardinis RJ. Understanding the Intersections between Metabolism and Cancer Biology. Cell. 168: 657-669. PMID 28187287 DOI: 10.1016/j.cell.2016.12.039  0.401
2016 Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, ... ... Vander Heiden MG, et al. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nature Medicine. PMID 28024083 DOI: 10.1038/Nm.4256  0.335
2016 Dayton TL, Jacks T, Vander Heiden MG. PKM2, cancer metabolism, and the road ahead. Embo Reports. PMID 27856534 DOI: 10.15252/Embr.201643300  0.465
2016 Gui DY, Sullivan LB, Luengo A, Hosios AM, Bush LN, Gitego N, Davidson SM, Freinkman E, Thomas CJ, Vander Heiden MG. Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin. Cell Metabolism. PMID 27746050 DOI: 10.1016/J.Cmet.2016.09.006  0.343
2016 Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, ... ... Vander Heiden MG, et al. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science (New York, N.Y.). 353: 1161-5. PMID 27609895 DOI: 10.1126/Science.Aaf5171  0.353
2016 Keibler MA, Wasylenko TM, Kelleher JK, Iliopoulos O, Vander Heiden MG, Stephanopoulos G. Metabolic requirements for cancer cell proliferation. Cancer & Metabolism. 4: 16. PMID 27540483 DOI: 10.1186/S40170-016-0156-6  0.428
2016 Mattaini KR, Sullivan MR, Vander Heiden MG. The importance of serine metabolism in cancer. The Journal of Cell Biology. PMID 27458133 DOI: 10.1083/jcb.201604085  0.412
2016 Pikman Y, Puissant A, Alexe G, Furman A, Chen LM, Frumm SM, Ross L, Fenouille N, Bassil CF, Lewis CA, Ramos A, Gould J, Stone RM, DeAngelo DJ, Galinsky I, ... ... Vander Heiden MG, et al. Targeting MTHFD2 in acute myeloid leukemia. The Journal of Experimental Medicine. PMID 27325891 DOI: 10.1084/Jem.20151574  0.324
2016 Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, ... ... Vander Heiden MG, et al. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. Cell Metabolism. PMID 26853747 DOI: 10.1016/J.Cmet.2016.01.007  0.315
2015 Son S, Stevens MM, Chao HX, Thoreen C, Hosios AM, Schweitzer LD, Weng Y, Wood K, Sabatini D, Vander Heiden MG, Manalis S. Cooperative nutrient accumulation sustains growth of mammalian cells. Scientific Reports. 5: 17401. PMID 26620632 DOI: 10.1038/Srep17401  0.31
2015 Lau AN, Vander Heiden MG. Stopping the Clock with MYC. Molecular Cell. 60: 511-3. PMID 26590710 DOI: 10.1016/j.molcel.2015.11.008  0.309
2015 Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, ... ... Vander Heiden MG, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Seminars in Cancer Biology. 35: S276-304. PMID 26590477 DOI: 10.1016/J.Semcancer.2015.09.007  0.64
2015 Liu VM, Vander Heiden MG. The Role of Pyruvate Kinase M2 in Cancer Metabolism. Brain Pathology (Zurich, Switzerland). 25: 781-3. PMID 26526946 DOI: 10.1111/bpa.12311  0.406
2015 Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, ... ... Vander Heiden MG, et al. Dysregulated metabolism contributes to oncogenesis. Seminars in Cancer Biology. PMID 26454069 DOI: 10.1016/j.semcancer.2015.10.002  0.72
2015 Israelsen WJ, Vander Heiden MG. Pyruvate kinase: Function, regulation and role in cancer. Seminars in Cell & Developmental Biology. PMID 26277545 DOI: 10.1016/j.semcdb.2015.08.004  0.405
2015 Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, ... ... Vander Heiden MG, et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 520: 363-7. PMID 25855294 DOI: 10.1038/Nature14363  0.455
2015 Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, ... ... Vander Heiden MG, et al. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current Opinion in Biotechnology. 34: 189-201. PMID 25731751 DOI: 10.1016/J.Copbio.2015.02.003  0.498
2015 Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, Thompson CB, Rabinowitz JD. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Research. 75: 544-53. PMID 25644265 DOI: 10.1158/0008-5472.Can-14-2211  0.452
2015 Mayers JR, Vander Heiden MG. Famine versus feast: understanding the metabolism of tumors in vivo. Trends in Biochemical Sciences. 40: 130-40. PMID 25639751 DOI: 10.1016/j.tibs.2015.01.004  0.398
2015 Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, ... ... Vander Heiden MG, et al. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Molecular Cell. 57: 95-107. PMID 25482511 DOI: 10.1016/J.Molcel.2014.10.027  0.589
2015 Anastasiou D, Locasale JW, Vander Heiden MG. Cancer metabolism Systems Biology of Cancer. 295-308. DOI: 10.1017/9780511979811.020  0.337
2015 Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PNM, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, ... ... Vander Heiden MG, et al. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation Molecular Cell. 57: 95-107. DOI: 10.1016/j.molcel.2014.10.027  0.518
2014 Hosios AM, Vander Heiden MG. Acetate metabolism in cancer cells. Cancer & Metabolism. 2: 27. PMID 25505945 DOI: 10.1186/s40170-014-0027-y  0.403
2014 Wang YH, Israelsen WJ, Lee D, Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, Scadden DT. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell. 158: 1309-23. PMID 25215489 DOI: 10.1016/J.Cell.2014.07.048  0.532
2014 Lewis CA, Parker SJ, Fiske BP, McCloskey D, Gui DY, Green CR, Vokes NI, Feist AM, Vander Heiden MG, Metallo CM. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. Molecular Cell. 55: 253-63. PMID 24882210 DOI: 10.1016/J.Molcel.2014.05.008  0.332
2014 Grassian AR, Parker SJ, Davidson SM, Divakaruni AS, Green CR, Zhang X, Slocum KL, Pu M, Lin F, Vickers C, Joud-Caldwell C, Chung F, Yin H, Handly ED, Straub C, ... ... Vander Heiden MG, et al. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Research. 74: 3317-31. PMID 24755473 DOI: 10.1158/0008-5472.Can-14-0772-T  0.359
2014 Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S, Vidal A, ... ... Vander Heiden MG, et al. A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect. Nature Communications. 5: 3608. PMID 24699711 DOI: 10.1038/Ncomms4608  0.302
2014 Dasgupta T, Croll DH, Owen JA, Vander Heiden MG, Locasale JW, Alon U, Cantley LC, Gunawardena J. A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis. The Journal of Biological Chemistry. 289: 13010-25. PMID 24634222 DOI: 10.1074/Jbc.M113.546515  0.574
2013 Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, ... ... Vander Heiden MG, et al. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 155: 397-409. PMID 24120138 DOI: 10.1016/J.Cell.2013.09.025  0.53
2013 Galluzzi L, Kepp O, Vander Heiden MG, Kroemer G. Metabolic targets for cancer therapy. Nature Reviews. Drug Discovery. 12: 829-46. PMID 24113830 DOI: 10.1038/Nrd4145  0.363
2013 Vander Heiden MG. Exploiting tumor metabolism: Challenges for clinical translation Journal of Clinical Investigation. 123: 3648-3651. PMID 23999437 DOI: 10.1172/JCI72391  0.405
2013 Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, ... ... Vander Heiden MG, et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Research. 73: 4429-38. PMID 23687346 DOI: 10.1158/0008-5472.Can-13-0080  0.525
2013 Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature. 497: 633-7. PMID 23665962 DOI: 10.1038/Nature12138  0.557
2013 Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K, Cantley LC, Vander Heiden MG, Vitkup D. Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nature Biotechnology. 31: 522-9. PMID 23604282 DOI: 10.1038/Nbt.2530  0.643
2013 Gui DY, Lewis CA, Vander Heiden MG. Allosteric regulation of PKM2 allows cellular adaptation to different physiological states. Science Signaling. 6: pe7. PMID 23423437 DOI: 10.1126/scisignal.2003925  0.305
2013 Metallo CM, Vander Heiden MG. Understanding Metabolic Regulation and Its Influence on Cell Physiology Molecular Cell. 49: 388-398. PMID 23395269 DOI: 10.1016/J.Molcel.2013.01.018  0.316
2012 Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, ... ... Vander Heiden MG, et al. Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Chemistry & Biology. 19: 1187-98. PMID 22999886 DOI: 10.1016/J.Chembiol.2012.07.021  0.592
2012 Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Vander Heiden MG, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/Nchembio.1060  0.713
2012 Fiske BP, Vander Heiden MG. Seeing the Warburg effect in the developing retina Nature Cell Biology. 14: 790-791. PMID 22854814 DOI: 10.1038/ncb2554  0.316
2012 Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, et al. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 149: 49-62. PMID 22401813 DOI: 10.1016/J.Cell.2012.02.030  0.562
2012 Davidson SM, Vander Heiden MG. METabolic adaptations in the tumor MYCroenvironment. Cell Metabolism. 15: 131-3. PMID 22326214 DOI: 10.1016/j.cmet.2012.01.005  0.387
2012 Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia Nature. 481: 380-384. PMID 22101433 DOI: 10.1038/Nature10602  0.365
2012 Wang Z, Chatterjee D, Jeon HY, Akerman M, Vander Heiden MG, Cantley LC, Krainer AR. Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. Journal of Molecular Cell Biology. 4: 79-87. PMID 22044881 DOI: 10.1093/Jmcb/Mjr030  0.487
2012 Locasale JW, Grassian A, Beroukhim R, Meyerson M, Wagner G, Asara JM, Brugge JS, Vander Heiden MG, Cantley LC. Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-O15  0.714
2012 Lyssiotis CA, Anastasiou D, Locasale JW, Vander Heiden MG, Christofk HR, Cantley LC. Cellular control mechanisms that regulate pyruvate kinase M2 activity and promote cancer growth Biomedical Research. 23: 213-217.  0.474
2011 Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW. Metabolic pathway alterations that support cell proliferation. Cold Spring Harbor Symposia On Quantitative Biology. 76: 325-34. PMID 22262476 DOI: 10.1101/Sqb.2012.76.010900  0.707
2011 Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science (New York, N.Y.). 334: 1278-83. PMID 22052977 DOI: 10.1126/Science.1211485  0.663
2011 Lunt SY, Vander Heiden MG. Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation Annual Review of Cell and Developmental Biology. 27: 441-464. PMID 21985671 DOI: 10.1146/annurev-cellbio-092910-154237  0.433
2011 Mullarky E, Mattaini KR, Vander Heiden MG, Cantley LC, Locasale JW. PHGDH amplification and altered glucose metabolism in human melanoma. Pigment Cell & Melanoma Research. 24: 1112-5. PMID 21981974 DOI: 10.1111/J.1755-148X.2011.00919.X  0.697
2011 Walsh MJ, Brimacombe KR, Veith H, Bougie JM, Daniel T, Leister W, Cantley LC, Israelsen WJ, Vander Heiden MG, Shen M, Auld DS, Thomas CJ, Boxer MB. 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 21: 6322-7. PMID 21958545 DOI: 10.1016/J.Bmcl.2011.08.114  0.564
2011 Vander Heiden MG. Targeting cancer metabolism: A therapeutic window opens Nature Reviews Drug Discovery. 10: 671-684. PMID 21878982 DOI: 10.1038/nrd3504  0.396
2011 Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, et al. Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell. 146: 607-20. PMID 21854985 DOI: 10.1016/J.Cell.2011.06.050  0.587
2011 Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, ... ... Vander Heiden MG, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. 43: 869-74. PMID 21804546 DOI: 10.1038/Ng.890  0.767
2010 Metallo CM, Vander Heiden MG. Metabolism strikes back: Metabolic flux regulates cell signaling Genes and Development. 24: 2717-2722. PMID 21159812 DOI: 10.1101/Gad.2010510  0.343
2010 Israelsen WJ, Vander Heiden MG. ATP consumption promotes cancer metabolism. Cell. 143: 669-71. PMID 21111226 DOI: 10.1016/j.cell.2010.11.010  0.361
2010 Locasale JW, Vander Heiden MG, Cantley LC. Rewiring of glycolysis in cancer cell metabolism. Cell Cycle (Georgetown, Tex.). 9: 4253. PMID 21045562 DOI: 10.4161/Cc.9.21.13925  0.687
2010 Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (New York, N.Y.). 329: 1492-9. PMID 20847263 DOI: 10.1126/Science.1188015  0.713
2010 Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Molecular Cell. 39: 171-83. PMID 20670887 DOI: 10.1016/J.Molcel.2010.06.022  0.323
2010 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... ... Vander Heiden MG, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 465: 966. PMID 20559394 DOI: 10.1038/nature09132  0.518
2010 Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Molecular Cell. 38: 487-99. PMID 20513425 DOI: 10.1016/J.Molcel.2010.05.007  0.495
2010 Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Molecular Cell. 38: 487-99. PMID 20513425 DOI: 10.1016/J.Molcel.2010.05.007  0.495
2010 Bonuccelli G, Whitaker-Menezes D, Castello-Cros R, Pavlides S, Pestell RG, Fatatis A, Witkiewicz AK, Vander Heiden MG, Migneco G, Chiavarina B, Frank PG, Capozza F, Flomenberg N, Martinez-Outschoorn UE, Sotgia F, et al. The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts. Cell Cycle (Georgetown, Tex.). 9: 1960-71. PMID 20495363 DOI: 10.4161/Cc.9.10.11601  0.346
2010 Bonuccelli G, Whitaker-Menezes D, Castello-Cros R, Pavlides S, Pestell RG, Fatatis A, Witkiewicz AK, Vander Heiden MG, Migneco G, Chiavarina B, Frank PG, Capozza F, Flomenberg N, Martinez-Outschoorn UE, Sotgia F, et al. The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts. Cell Cycle (Georgetown, Tex.). 9: 1960-71. PMID 20495363 DOI: 10.4161/Cc.9.10.11601  0.346
2010 Vander Heiden MG. Targeting cell metabolism in cancer patients Science Translational Medicine. 2: 31ed1. PMID 20463364 DOI: 10.1126/scitranslmed.3001210  0.347
2010 Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/J.Bmcl.2010.04.015  0.546
2010 Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/J.Bmcl.2010.04.015  0.546
2010 Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR. The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proceedings of the National Academy of Sciences of the United States of America. 107: 1894-9. PMID 20133837 DOI: 10.1073/Pnas.0914845107  0.73
2010 Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. 53: 1048-55. PMID 20017496 DOI: 10.1021/Jm901577G  0.509
2010 Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. 53: 1048-55. PMID 20017496 DOI: 10.1021/Jm901577G  0.509
2010 Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. Identification of small molecule inhibitors of pyruvate kinase M2. Biochemical Pharmacology. 79: 1118-24. PMID 20005212 DOI: 10.1016/J.Bcp.2009.12.003  0.591
2010 Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. Identification of small molecule inhibitors of pyruvate kinase M2. Biochemical Pharmacology. 79: 1118-24. PMID 20005212 DOI: 10.1016/J.Bcp.2009.12.003  0.591
2009 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... ... Vander Heiden MG, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 462: 739-44. PMID 19935646 DOI: 10.1038/Nature08617  0.534
2009 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... ... Vander Heiden MG, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 462: 739-44. PMID 19935646 DOI: 10.1038/Nature08617  0.534
2009 Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Science Signaling. 2: ra73. PMID 19920251 DOI: 10.1126/Scisignal.2000431  0.551
2009 Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Science Signaling. 2: ra73. PMID 19920251 DOI: 10.1126/Scisignal.2000431  0.551
2009 Locasale JW, Cantley LC, Vander Heiden MG. Cancer's insatiable appetite. Nature Biotechnology. 27: 916-7. PMID 19816448 DOI: 10.1038/Nbt1009-916  0.661
2009 Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (New York, N.Y.). 324: 1029-33. PMID 19460998 DOI: 10.1126/Science.1160809  0.672
2009 Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, et al. Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (New York, N.Y.). 324: 626-31. PMID 19407199 DOI: 10.1126/Science.1165069  0.311
2008 Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 452: 230-3. PMID 18337823 DOI: 10.1038/Nature06734  0.564
2008 Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 452: 230-3. PMID 18337823 DOI: 10.1038/Nature06734  0.564
2008 Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein Nature. 452: 181-186. PMID 18337815 DOI: 10.1038/Nature06667  0.472
2002 Vander Heiden MG, Choy JS, VanderWeele DJ, Brace JL, Harris MH, Bauer DE, Prange B, Kron SJ, Thompson CB, Rudin CM. Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. The Journal of Biological Chemistry. 277: 44870-6. PMID 12244097 DOI: 10.1074/Jbc.M204888200  0.59
2002 Vander Heiden MG, Choy JS, VanderWeele DJ, Brace JL, Harris MH, Bauer DE, Prange B, Kron SJ, Thompson CB, Rudin CM. Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. The Journal of Biological Chemistry. 277: 44870-6. PMID 12244097 DOI: 10.1074/Jbc.M204888200  0.59
2002 Zhou R, Vander Heiden MG, Rudin CM. Genotoxic exposure is associated with alterations in glucose uptake and metabolism. Cancer Research. 62: 3515-20. PMID 12067998  0.53
2002 Zhou R, Vander Heiden MG, Rudin CM. Genotoxic exposure is associated with alterations in glucose uptake and metabolism. Cancer Research. 62: 3515-20. PMID 12067998  0.53
2001 Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, Thompson CB. Growth factors can influence cell growth and survival through effects on glucose metabolism Molecular and Cellular Biology. 21: 5899-5912. PMID 11486029 DOI: 10.1128/Mcb.21.17.5899-5912.2001  0.468
2001 Vander Heiden MG, Li XX, Gottleib E, Hill RB, Thompson CB, Colombini M. Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. The Journal of Biological Chemistry. 276: 19414-9. PMID 11259441 DOI: 10.1074/jbc.M101590200  0.382
2001 Vander Heiden MG, Li XX, Gottleib E, Hill RB, Thompson CB, Colombini M. Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane. The Journal of Biological Chemistry. 276: 19414-9. PMID 11259441 DOI: 10.1074/jbc.M101590200  0.382
2000 Rathmell JC, Vander Heiden MG, Harris MH, Frauwirth KA, Thompson CB. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Molecular Cell. 6: 683-92. PMID 11030347 DOI: 10.1016/S1097-2765(00)00066-6  0.497
2000 Chuang E, Fisher TS, Morgan RW, Robbins MD, Duerr JM, Vander Heiden MG, Gardner JP, Hambor JE, Neveu MJ, Thompson CB. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A Immunity. 13: 313-322. PMID 11021529 DOI: 10.1016/S1074-7613(00)00031-5  0.383
2000 Chandel NS, Vander Heiden MG, Thompson CB, Schumacker PT. Redox regulation of p53 during hypoxia Oncogene. 19: 3840-3848. PMID 10951577 DOI: 10.1038/Sj.Onc.1203727  0.452
2000 Gottlieb E, Vander Heiden MG, Thompson CB. Bcl-x(L) prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis Molecular and Cellular Biology. 20: 5680-5689. PMID 10891504 DOI: 10.1128/Mcb.20.15.5680-5689.2000  0.406
2000 Vander Heiden MG, Chandel NS, Li XX, Schumacker PT, Colombini M, Thompson CB. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proceedings of the National Academy of Sciences of the United States of America. 97: 4666-71. PMID 10781072 DOI: 10.1073/Pnas.090082297  0.409
2000 Vander Heiden MG, Chandel NS, Li XX, Schumacker PT, Colombini M, Thompson CB. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proceedings of the National Academy of Sciences of the United States of America. 97: 4666-71. PMID 10781072 DOI: 10.1073/Pnas.090082297  0.409
2000 Harris MH, Vander Heiden MG, Kron SJ, Thompson CB. Role of oxidative phosphorylation in Bax toxicity Molecular and Cellular Biology. 20: 3590-3596. PMID 10779348 DOI: 10.1128/Mcb.20.10.3590-3596.2000  0.438
1999 Thompson CB, Rathmell JC, Frauwirth KA, Lindsten T, Rudin CM, Opferman JT, Ashton-Rickardt PG, Harris MH, Chandel NS, Schumacker PT, Vander Heiden MG. What keeps a resting T cell alive? Cold Spring Harbor Symposia On Quantitative Biology. 64: 383-7. PMID 11232311 DOI: 10.1101/Sqb.1999.64.383  0.509
1999 Thompson CB, Rathmell JC, Frauwirth KA, Lindsten T, Rudin CM, Opferman JT, Ashton-Rickardt PG, Harris MH, Chandel NS, Schumacker PT, Vander Heiden MG. What keeps a resting T cell alive? Cold Spring Harbor Symposia On Quantitative Biology. 64: 383-7. PMID 11232311 DOI: 10.1101/Sqb.1999.64.383  0.509
1999 Vander Heiden MG, Thompson CB. Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis? Nature Cell Biology. 1: E209-E216. PMID 10587660  0.396
1999 Vander Heiden MG, Chandel NS, Schumacker PT, Thompson CB. Bcl-x(L) prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange Molecular Cell. 3: 159-167. PMID 10078199 DOI: 10.1016/S1097-2765(00)80307-X  0.443
1999 Minn AJ, Kettlun CS, Liang H, Kelekar A, Vander Heiden MG, Chang BS, Fesik SW, Fill M, Thompson CB. Bcl-x(L) regulates apoptosis by heterodimerization-dependent and -independent mechanisms Embo Journal. 18: 632-643. PMID 9927423 DOI: 10.1093/Emboj/18.3.632  0.425
1997 Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB. Bcl-x(L) regulates the membrane potential and volume homeostasis of mitochondria Cell. 91: 627-637. PMID 9393856 DOI: 10.1016/S0092-8674(00)80450-X  0.395
1997 Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB. Interaction of CTLA-4 with the Clathrin-Associated Protein AP50 Results in Ligand-Independent Endocytosis That Limits Cell Surface Expression Journal of Immunology. 159: 144-151. PMID 9200449  0.414
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