| Year |
Citation |
Score |
| 2013 |
Michalowski CB, Little JW. Role of cis-acting sites in stimulation of the phage λ P(RM) promoter by CI-mediated looping. Journal of Bacteriology. 195: 3401-11. PMID 23708136 DOI: 10.1128/Jb.02148-12 |
0.349 |
|
| 2010 |
Little JW, Michalowski CB. Stability and instability in the lysogenic state of phage lambda. Journal of Bacteriology. 192: 6064-76. PMID 20870769 DOI: 10.1128/Jb.00726-10 |
0.35 |
|
| 2010 |
Little JW. Evolution of complex gene regulatory circuits by addition of refinements. Current Biology : Cb. 20: R724-34. PMID 20833317 DOI: 10.1016/J.Cub.2010.06.028 |
0.323 |
|
| 2008 |
Giese KC, Michalowski CB, Little JW. RecA-Dependent Cleavage of LexA Dimers Journal of Molecular Biology. 377: 148-161. PMID 18234215 DOI: 10.1016/J.Jmb.2007.12.025 |
0.352 |
|
| 2007 |
Babić AC, Little JW. Cooperative DNA binding by CI repressor is dispensable in a phage λ variant Proceedings of the National Academy of Sciences of the United States of America. 104: 17741-17746. PMID 17962420 DOI: 10.1073/Pnas.0602223104 |
0.447 |
|
| 2007 |
Degnan PH, Michalowski CB, Babić AC, Cordes MHJ, Little JW. Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage λ Molecular Microbiology. 64: 232-244. PMID 17376085 DOI: 10.1111/J.1365-2958.2007.05650.X |
0.34 |
|
| 2006 |
Atsumi S, Little JW. A synthetic phage lambda regulatory circuit. Proceedings of the National Academy of Sciences of the United States of America. 103: 19045-50. PMID 17135356 DOI: 10.1073/Pnas.0603052103 |
0.598 |
|
| 2006 |
Atsumi S, Little JW. Role of the lytic repressor in prophage induction of phage lambda as analyzed by a module-replacement approach. Proceedings of the National Academy of Sciences of the United States of America. 103: 4558-63. PMID 16537413 DOI: 10.1073/Pnas.0511117103 |
0.59 |
|
| 2005 |
Michalowski CB, Little JW. Positive autoregulation of cI is a dispensable feature of the phage λ gene regulatory circuitry Journal of Bacteriology. 187: 6430-6442. PMID 16159777 DOI: 10.1128/Jb.187.18.6430-6442.2005 |
0.385 |
|
| 2005 |
Okon M, Pfuetzner RA, Vuckovic M, Little JW, Strynadka NC, McIntosh LP. Backbone chemical shift assignments of the LexA catalytic domain in its active conformation. Journal of Biomolecular Nmr. 31: 371-2. PMID 15929009 DOI: 10.1007/S10858-005-0944-8 |
0.36 |
|
| 2005 |
Little JW. Threshold effects in gene regulation: When some is not enough Proceedings of the National Academy of Sciences of the United States of America. 102: 5310-5311. PMID 15811940 DOI: 10.1073/Pnas.0501645102 |
0.386 |
|
| 2004 |
Michalowski CB, Short MD, Little JW. Sequence tolerance of the phage λ PRM promoter: Implications for evolution of gene regulatory circuitry Journal of Bacteriology. 186: 7988-7999. PMID 15547271 DOI: 10.1128/Jb.186.23.7988-7999.2004 |
0.4 |
|
| 2004 |
Atsumi S, Little JW. Regulatory circuit design and evolution using phage lambda. Genes & Development. 18: 2086-94. PMID 15342489 DOI: 10.1101/gad.1226004 |
0.501 |
|
| 2001 |
Luo Y, Pfuetzner RA, Mosimann S, Paetzel M, Frey EA, Cherney M, Kim B, Little JW, Strynadka NC. Crystal structure of LexA: a conformational switch for regulation of self-cleavage. Cell. 106: 585-94. PMID 11551506 DOI: 10.1016/S0092-8674(01)00479-2 |
0.332 |
|
| 2000 |
Mustard JA, Little JW. Analysis of Escherichia coli RecA interactions with LexA, λ CI, and UmuD by site-directed mutagenesis of recA Journal of Bacteriology. 182: 1659-1670. PMID 10692372 DOI: 10.1128/Jb.182.6.1659-1670.2000 |
0.434 |
|
| 1999 |
Weisberg RA, Gottesmann ME, Hendrix RW, Little JW. Family values in the age of genomics: comparative analyses of temperate bacteriophage HK022. Annual Review of Genetics. 33: 565-602. PMID 10690418 DOI: 10.1146/Annurev.Genet.33.1.565 |
0.519 |
|
| 1999 |
Little JW, Shepley DP, Wert DW. Robustness of a gene regulatory circuit Embo Journal. 18: 4299-4307. PMID 10428968 DOI: 10.1093/Emboj/18.15.4299 |
0.35 |
|
| 1998 |
Mao C, Little JW. Mutations affecting cooperative DNA binding of phage HK022 CI repressor Journal of Molecular Biology. 279: 31-48. PMID 9636698 DOI: 10.1006/Jmbi.1998.1725 |
0.447 |
|
| 1998 |
Liu Z, Little JW. The spacing between binding sites controls the mode of cooperative DNA-protein interactions: Implications for evolution of regulatory circuitry Journal of Molecular Biology. 278: 331-338. PMID 9571055 DOI: 10.1006/Jmbi.1998.1695 |
0.366 |
|
| 1996 |
Shepley DP, Little JW. Mutant LexA proteins with specific defects in autodigestion Proceedings of the National Academy of Sciences of the United States of America. 93: 11528-11533. PMID 8876169 DOI: 10.1073/Pnas.93.21.11528 |
0.372 |
|
| 1994 |
Mao C, Carlson NG, Little JW. Cooperative DNA-protein interactions. Effects of changing the spacing between adjacent binding sites. Journal of Molecular Biology. 235: 532-44. PMID 8289280 DOI: 10.1006/Jmbi.1994.1011 |
0.391 |
|
| 1994 |
Little JW, Kim B, Roland KL, Smith MH, Lin LL, Slilaty SN. Cleavage of LexA repressor Methods in Enzymology. 244: 266-284. PMID 7845214 DOI: 10.1016/0076-6879(94)44022-0 |
0.422 |
|
| 1993 |
Kim B, Little JW. LexA and λ Cl repressors as enzymes: Specific cleavage in an intermolecular reaction Cell. 73: 1165-1173. PMID 8513500 DOI: 10.1016/0092-8674(93)90645-7 |
0.371 |
|
| 1993 |
Carlson NG, Little JW. Highly cooperative DNA binding by the coliphage HK022 repressor. Journal of Molecular Biology. 230: 1108-30. PMID 8487297 DOI: 10.1006/Jmbi.1993.1229 |
0.426 |
|
| 1993 |
Carlson NG, Little JW. A novel antivirulence element in the temperate bacteriophage HK022. Journal of Bacteriology. 175: 7541-9. PMID 8244923 DOI: 10.1128/Jb.175.23.7541-7549.1993 |
0.396 |
|
| 1993 |
Ennis DG, Little JW, Mount DW. Novel mechanism for UV sensitivity and apparent UV nonmutability of recA432 mutants: persistent LexA cleavage following SOS induction. Journal of Bacteriology. 175: 7373-82. PMID 8226685 DOI: 10.1128/Jb.175.22.7373-7382.1993 |
0.363 |
|
| 1992 |
Kim B, Little JW. Dimerization of a specific DNA-binding protein on the DNA. Science (New York, N.Y.). 255: 203-6. PMID 1553548 DOI: 10.1126/Science.1553548 |
0.387 |
|
| 1992 |
Roland KL, Smith MH, Rupley JA, Little JW. In vitro analysis of mutant LexA proteins with an increased rate of specific cleavage. Journal of Molecular Biology. 228: 395-408. PMID 1453451 DOI: 10.1016/0022-2836(92)90829-9 |
0.383 |
|
| 1991 |
Thliveris AT, Little JW, Mount DW. Repression of the E coli recA gene requires at least two LexA protein monomers. Biochimie. 73: 449-56. PMID 1911945 DOI: 10.1016/0300-9084(91)90112-E |
0.436 |
|
| 1991 |
Little JW. Mechanism of specific LexA cleavage: autodigestion and the role of RecA coprotease. Biochimie. 73: 411-21. PMID 1911941 DOI: 10.1016/0300-9084(91)90108-D |
0.378 |
|
| 1991 |
Smith MH, Cavenagh MM, Little JW. Mutant LexA proteins with an increased rate of in vivo cleavage. Proceedings of the National Academy of Sciences of the United States of America. 88: 7356-60. PMID 1908093 DOI: 10.1073/Pnas.88.16.7356 |
0.406 |
|
| 1990 |
Lin LL, Little JW. Autodigestion and RecA-dependent cleavage of Ind- mutant LexA proteins. Journal of Molecular Biology. 210: 439-52. PMID 2693734 DOI: 10.1016/0022-2836(89)90121-6 |
0.367 |
|
| 1990 |
Little JW. Saturation mutagenesis of specific codons: elimination of molecules with stop codons from mixed pools of DNA. Gene. 88: 113-5. PMID 2341037 DOI: 10.1016/0378-1119(90)90067-2 |
0.327 |
|
| 1989 |
Hill SA, Little JW. Allele replacement in Escherichia coli by use of a selectable marker for resistance to spectinomycin: replacement of the lexA gene. Journal of Bacteriology. 170: 5913-5. PMID 2848016 DOI: 10.1128/Jb.170.12.5913-5915.1988 |
0.332 |
|
| 1988 |
Lin LL, Little JW. Isolation and characterization of noncleavable (Ind-) mutants of the LexA repressor of Escherichia coli K-12. Journal of Bacteriology. 170: 2163-73. PMID 2834329 DOI: 10.1128/Jb.170.5.2163-2173.1988 |
0.44 |
|
| 1987 |
Slilaty SN, Little JW. Lysine-156 and serine-119 are required for LexA repressor cleavage: a possible mechanism. Proceedings of the National Academy of Sciences of the United States of America. 84: 3987-91. PMID 3108885 DOI: 10.1073/Pnas.84.12.3987 |
0.394 |
|
| 1986 |
Slilaty SN, Rupley JA, Little JW. Intramolecular cleavage of LexA and phage lambda repressors: dependence of kinetics on repressor concentration, pH, temperature, and solvent. Biochemistry. 25: 6866-75. PMID 2948553 DOI: 10.1021/Bi00370A020 |
0.306 |
|
| 1984 |
West SC, Little JW. P. mirabilis RecA protein catalyses cleavage of E. coli LexA protein and the lambda repressor in vitro. Molecular & General Genetics : Mgg. 194: 111-3. PMID 6374373 DOI: 10.1007/Bf00383505 |
0.379 |
|
| 1984 |
Little JW. Autodigestion of lexA and phage lambda repressors. Proceedings of the National Academy of Sciences of the United States of America. 81: 1375-9. PMID 6231641 DOI: 10.1073/Pnas.81.5.1375 |
0.386 |
|
| 1984 |
Little JW, Mount DW. Creating new restriction sites by silent changes in coding sequences. Gene. 32: 67-73. PMID 6099315 DOI: 10.1016/0378-1119(84)90033-7 |
0.336 |
|
| 1983 |
Little JW. Control of the SOS regulatory system by the level of RecA protease. Biochimie. 64: 585-9. PMID 6814506 DOI: 10.1016/S0300-9084(82)80092-8 |
0.373 |
|
| 1983 |
Little JW. The SOS regulatory system: control of its state by the level of RecA protease. Journal of Molecular Biology. 167: 791-808. PMID 6410076 DOI: 10.1016/S0022-2836(83)80111-9 |
0.359 |
|
| 1982 |
Little JW, Mount DW. The SOS regulatory system of Escherichia coli. Cell. 29: 11-22. PMID 7049397 DOI: 10.1016/0092-8674(82)90085-X |
0.315 |
|
| 1982 |
Sancar A, Sancar GB, Rupp WD, Little JW, Mount DW. LexA protein inhibits transcription of the E. coli uvrA gene in vitro. Nature. 298: 96-8. PMID 6283374 DOI: 10.1038/298096A0 |
0.301 |
|
| 1982 |
Sancar GB, Sancar A, Little JW, Rupp WD. The uvrB gene of Escherichia coli has both lexA-repressed and lexA-independent promoters. Cell. 28: 523-30. PMID 6280873 DOI: 10.1016/0092-8674(82)90207-0 |
0.314 |
|
| 1981 |
Little JW, Mount DW, Yanisch-Perron CR. Purified lexA protein is a repressor of the recA and lexA genes. Proceedings of the National Academy of Sciences of the United States of America. 78: 4199-203. PMID 7027255 DOI: 10.1073/Pnas.78.7.4199 |
0.439 |
|
| 1981 |
Cohen S, Knoll BJ, Little JW, Mount DW. Preferential cleavage of phage lambda repressor monomers by recA protease. Nature. 294: 182-4. PMID 6457991 DOI: 10.1038/294182A0 |
0.429 |
|
| 1981 |
Markham BE, Little JW, Mount DW. Nucleotide sequence of the lexA gene of Escherichia coli K-12. Nucleic Acids Research. 9: 4149-61. PMID 6272195 DOI: 10.1093/Nar/9.16.4149 |
0.383 |
|
| 1980 |
Mount DW, Little JW, Edmiston SH. Influence of plasmids carrying the lexA gene on DNA repair and related processes in Escherichia coli K-12. Molecular & General Genetics : Mgg. 177: 477-83. PMID 6990203 DOI: 10.1007/Bf00271487 |
0.395 |
|
| 1980 |
Little JW, Edmiston SH, Pacelli LZ, Mount DW. Cleavage of the Escherichia coli lexA protein by the recA protease. Proceedings of the National Academy of Sciences of the United States of America. 77: 3225-9. PMID 6447873 DOI: 10.1073/Pnas.77.6.3225 |
0.422 |
|
| 1980 |
Little JW. Isolation of recombinant plasmids and phage carrying the lexA gene of Escherichia coli K-12. Gene. 10: 237-47. PMID 6254842 DOI: 10.1016/0378-1119(80)90053-0 |
0.361 |
|
| 1979 |
Little JW. Construction and characterization of a plasmid coding for a fragment of the Escherichia coli recA protein. Molecular & General Genetics : Mgg. 177: 13-22. PMID 395410 DOI: 10.1007/Bf00267248 |
0.378 |
|
| 1979 |
Little JW, Harper JE. Identification of the lexA gene product of Escherichia coli K-12. Proceedings of the National Academy of Sciences of the United States of America. 76: 6147-51. PMID 160562 DOI: 10.1073/Pnas.76.12.6147 |
0.393 |
|
| 1969 |
Gellert M, Little JW, Oshinsky CK, Zimmerman SB. Joining of DNA strands by DNA ligase of E. coli. Cold Spring Harbor Symposia On Quantitative Biology. 33: 21-6. PMID 4306814 DOI: 10.1101/Sqb.1968.033.01.007 |
0.312 |
|
| 1968 |
Little JW, Zimmerman SB, Oshinsky CK, Gellert M. Enzymatic joining of DNA strands, II. An enzyme-adenylate intermediate in the dpn-dependent DNA ligase reaction. Proceedings of the National Academy of Sciences of the United States of America. 58: 2004-11. PMID 4295585 DOI: 10.1073/Pnas.58.5.2004 |
0.349 |
|
| 1967 |
Little JW, Lehman IR, Kaiser AD. An exonuclease induced by bacteriophage lambda. I. Preparation of the crystalline enzyme. The Journal of Biological Chemistry. 242: 672-8. PMID 6017736 |
0.467 |
|
| 1967 |
Zimmerman SB, Little JW, Oshinsky CK, Gellert M. Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide. Proceedings of the National Academy of Sciences of the United States of America. 57: 1841-8. PMID 4291949 DOI: 10.1073/Pnas.57.6.1841 |
0.326 |
|
| 1967 |
Little JW. [34a] An exonuclease induced by bacteriophage lambda Methods in Enzymology. 12: 263-269. DOI: 10.1016/S0076-6879(67)12041-7 |
0.343 |
|
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