Michael A. Trakselis, Ph.D.
Affiliations: | 2002 | Pennsylvania State University, State College, PA, United States | |
| 2014- | Chemistry and Biochemistry | Baylor University, Waco, TX |
Area:
mechanistic enzymologyWebsite:
https://www.baylor.edu/chemistry/index.php?id=950877Google:
"Michael Trakselis"Parents
Sign in to add mentor| Stephen J. Benkovic | grad student | 2002 | Penn State | |
| (Kinetics and macromolecular interactions within the bacteriophage T4 DNA polymerase holoenzyme and replisome.) | ||||
| Ron A. Laskey | post-doc | 2003-2006 | University of Cambridge, Hutchison/MRC Research Centre | |
Children
Sign in to add trainee| Zhongfeng Zuo | grad student | 2012 | University of Pittsburgh |
| Hsiang-Kai Lin | grad student | 2013 | University of Pittsburgh |
| Robert Bauer | grad student | 2014 | University of Pittsburgh |
| Brian Graham | grad student | 2014 | University of Pittsburgh |
| Elizabeth Jeffries | grad student | 2015 | University of Pittsburgh |
| Sean Carney | grad student | 2016 | University of Pittsburgh |
| Matthew Cranford | grad student | 2020 | Baylor University |
| Wezley Colyn Griffin | post-doc | 2017-2020 | Baylor University |
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Publications
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| Butterworth LJ, Welikala MU, Klatt CW, et al. (2025) Replisomal coupling between the α-Pol III core and the τ-subunit of the clamp loader complex (CLC) are essential for genomic integrity in E. coli. The Journal of Biological Chemistry. 108177 |
| Welikala MU, Butterworth LJ, Behrmann MS, et al. (2024) Tau mediated coupling between Pol III synthesis and DnaB helicase unwinding helps maintain genomic stability. The Journal of Biological Chemistry. 107726 |
| Behrmann MS, Perera HM, Welikala MU, et al. (2024) Dysregulated DnaB unwinding induces replisome decoupling and daughter strand gaps that are countered by RecA polymerization. Nucleic Acids Research |
| McKinzey DR, Li C, Gao Y, et al. (2023) Activity, substrate preference and structure of the HsMCM8/9 helicase. Nucleic Acids Research |
| Griffin WC, McKinzey DR, Klinzing KN, et al. (2022) A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress. Nature Communications. 13: 5090 |
| Behrmann MS, Trakselis MA. (2022) In vivo fluorescent TUNEL detection of single stranded DNA gaps and breaks induced by dnaB helicase mutants in Escherichia coli. Methods in Enzymology. 672: 125-142 |
| Kaszubowski JD, Trakselis MA. (2021) Beyond the Lesion: Back to High Fidelity DNA Synthesis. Frontiers in Molecular Biosciences. 8: 811540 |
| Behrmann MS, Perera HM, Hoang JM, et al. (2021) Targeted chromosomal Escherichia coli: dnaB exterior surface residues regulate DNA helicase behavior to maintain genomic stability and organismal fitness. Plos Genetics. 17: e1009886 |
| Perera HM, Trakselis MA. (2021) Determining translocation orientations of nucleic acid helicases. Methods (San Diego, Calif.) |
| McKinzey DR, Gomathinayagam S, Griffin WC, et al. (2021) Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment. The Journal of Biological Chemistry. 100355 |