Thomas T. Joseph, M.D., Ph.D.
Affiliations: | 2003-2011 | Biophysics, Structural Biology, and Biomathematics | Icahn School of Medicine at Mount Sinai, New York, NY, United States |
| 2003-2012 | Medicine | Icahn School of Medicine at Mount Sinai, New York, NY, United States | |
| 2012-2016 | Anesthesiology, Perioperative and Pain medicine | Icahn School of Medicine at Mount Sinai, New York, NY, United States | |
| 2016- | Anesthesiology and Critical Care | University of Pennsylvania Perelman School of Medicine |
Area:
Biophysics, AnesthesiologyWebsite:
https://www.med.upenn.edu/apps/faculty/index.php/g275/p8927371Google:
"Thomas Joseph"Parents
Sign in to add mentor| Roman Osman | grad student | 2011 | Mount Sinai School of Medicine | |
| (Guide-target mismatches in RNA interference.) | ||||
| Grace Brannigan | post-doc | 2016-2018 | Rutgers University Camden | |
| Roderic G. Eckenhoff | post-doc | 2016-2018 | Penn | |
Children
Sign in to add trainee| Sruthi Murlidaran | post-doc | 2019-2020 | University of Pennsylvania Perelman School of Medicine |
BETA: Related publications
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Publications
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| Riel EB, Bu W, Joseph TT, et al. (2025) The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel. Proceedings of the National Academy of Sciences of the United States of America. 122: e2421654122 |
| Joseph TT, Bu W, Haji-Ghassemi O, et al. (2024) Propofol binds and inhibits skeletal muscle ryanodine receptor 1. British Journal of Anaesthesia |
| Pitman C, Santiago-McRae E, Lohia R, et al. (2024) The blobulator: a webtool for identification and visual exploration of hydrophobic modularity in protein sequences. Biorxiv : the Preprint Server For Biology |
| Joseph TT, Bu W, Haji-Ghassemi O, et al. (2024) Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1). Biorxiv : the Preprint Server For Biology |
| Becker-Baldus J, Yeliseev A, Joseph TT, et al. (2023) Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent Micelles. Acs Omega. 8: 32963-32976 |
| Petroff JT, Dietzen NM, Santiago-McRae E, et al. (2022) Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation. Nature Communications. 13: 7017 |
| Joseph TT. (2022) Best practices for resilient automation of biomolecular simulations. Methods in Cell Biology. 169: 199-219 |
| Joseph TT, Bu W, Lin W, et al. (2021) Ketamine Metabolite (2,6)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors. Acs Chemical Neuroscience |
| Yeliseev A, Iyer MR, Joseph TT, et al. (2021) Cholesterol as a modulator of cannabinoid receptor CB signaling. Scientific Reports. 11: 3706 |
| Wague A, Joseph TT, Woll KA, et al. (2020) Mechanistic insights into volatile anesthetic modulation of K2P channels. Elife. 9 |