Thomas T. Joseph, M.D., Ph.D. - Publications

Affiliations: 
2003-2011 Biophysics, Structural Biology, and Biomathematics Icahn School of Medicine at Mount Sinai, New York, NY, United States 
 2003-2012 Medicine Icahn School of Medicine at Mount Sinai, New York, NY, United States 
 2012-2016 Anesthesiology, Perioperative and Pain medicine Icahn School of Medicine at Mount Sinai, New York, NY, United States 
 2016- Anesthesiology and Critical Care University of Pennsylvania Perelman School of Medicine 
Area:
Biophysics, Anesthesiology
Website:
https://www.med.upenn.edu/apps/faculty/index.php/g275/p8927371

28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Riel EB, Bu W, Joseph TT, Khajoueinejad L, Eckenhoff RG, Riegelhaupt PM. The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel. Proceedings of the National Academy of Sciences of the United States of America. 122: e2421654122. PMID 40178898 DOI: 10.1073/pnas.2421654122  0.483
2024 Joseph TT, Bu W, Haji-Ghassemi O, Chen YS, Woll K, Allen PD, Brannigan G, van Petegem F, Eckenhoff RG. Propofol binds and inhibits skeletal muscle ryanodine receptor 1. British Journal of Anaesthesia. PMID 39304470 DOI: 10.1016/j.bja.2024.06.048  0.728
2024 Pitman C, Santiago-McRae E, Lohia R, Bassi K, Joseph TT, Hansen MEB, Brannigan G. The blobulator: a webtool for identification and visual exploration of hydrophobic modularity in protein sequences. Biorxiv : the Preprint Server For Biology. PMID 38293114 DOI: 10.1101/2024.01.15.575761  0.693
2024 Joseph TT, Bu W, Haji-Ghassemi O, Chen YS, Woll K, Allen PD, Brannigan G, van Petegem F, Eckenhoff RG. Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1). Biorxiv : the Preprint Server For Biology. PMID 38260485 DOI: 10.1101/2024.01.10.575040  0.757
2023 Becker-Baldus J, Yeliseev A, Joseph TT, Sigurdsson ST, Zoubak L, Hines K, Iyer MR, van den Berg A, Stepnowski S, Zmuda J, Gawrisch K, Glaubitz C. Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent Micelles. Acs Omega. 8: 32963-32976. PMID 37720784 DOI: 10.1021/acsomega.3c04681  0.417
2022 Petroff JT, Dietzen NM, Santiago-McRae E, Deng B, Washington MS, Chen LJ, Trent Moreland K, Deng Z, Rau M, Fitzpatrick JAJ, Yuan P, Joseph TT, Hénin J, Brannigan G, Cheng WWL. Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation. Nature Communications. 13: 7017. PMID 36385237 DOI: 10.1038/s41467-022-34813-5  0.703
2022 Joseph TT. Best practices for resilient automation of biomolecular simulations. Methods in Cell Biology. 169: 199-219. PMID 35623702 DOI: 10.1016/bs.mcb.2021.12.004  0.228
2021 Joseph TT, Bu W, Lin W, Zoubak L, Yeliseev A, Liu R, Eckenhoff RG, Brannigan G. Ketamine Metabolite (2,6)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors. Acs Chemical Neuroscience. PMID 33905229 DOI: 10.1021/acschemneuro.0c00741  0.748
2021 Yeliseev A, Iyer MR, Joseph TT, Coffey NJ, Cinar R, Zoubak L, Kunos G, Gawrisch K. Cholesterol as a modulator of cannabinoid receptor CB signaling. Scientific Reports. 11: 3706. PMID 33580091 DOI: 10.1038/s41598-021-83245-6  0.413
2020 Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM. Mechanistic insights into volatile anesthetic modulation of K2P channels. Elife. 9. PMID 33345771 DOI: 10.7554/eLife.59839  0.581
2020 Wenric S, Jeff JM, Joseph T, Yee MC, Belbin GM, Owusu Obeng A, Ellis SB, Bottinger EP, Gottesman O, Levin MA, Kenny EE. Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry. The Pharmacogenomics Journal. PMID 33168928 DOI: 10.1038/s41397-020-00194-5  0.244
2020 Joseph TT, Wax DB, Goldstein R, Huang J, McCormick PJ, Levin MA. A Web-Based Perioperative Dashboard as a Platform for Anesthesia Informatics Innovation. Anesthesia and Analgesia. 131: 1640-1645. PMID 33079890 DOI: 10.1213/ANE.0000000000005193  0.214
2020 Joseph TT, Wax DB, Goldstein R, Huang J, McCormick PJ, Levin MA. A Web-Based Perioperative Dashboard as a Platform for Anesthesia Informatics Innovation. Anesthesia and Analgesia. PMID 32947293 DOI: 10.1213/Ane.0000000000005193  0.321
2020 Murlidaran S, Bu W, Eckenhoff RG, Brannigan GH, Joseph TT. Relative Affinities of General Anesthetics for Experimentally Identified Binding Sites in Ryanodine Receptors (RyR1) Biophysical Journal. 118: 115a. DOI: 10.1016/J.Bpj.2019.11.771  0.719
2019 McKinstry-Wu A, Woll KA, Joseph T, Bu W, White ER, Bhanu NV, Garcia BA, Brannigan G, Dailey WP, Eckenhoff RG. Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand. Acs Chemical Neuroscience. PMID 31638765 DOI: 10.1021/Acschemneuro.9B00484  0.752
2018 Salari R, Joseph T, Lohia R, Hénin J, Brannigan G. A streamlined, general approach for computing ligand binding free energies and its application to GPCR-bound cholesterol. Journal of Chemical Theory and Computation. PMID 30358394 DOI: 10.1021/Acs.Jctc.8B00447  0.703
2018 Kass JL, Lakha S, Levin MA, Joseph T, Lin HM, Genden EM, Teng MS, Miles BA, DeMaria S. Intraoperative hypotension and flap loss in free tissue transfer surgery of the head and neck. Head & Neck. PMID 30230116 DOI: 10.1002/Hed.25190  0.318
2018 Flaherty D, Kim S, Zerillo J, Park C, Joseph T, Hill B, Lin HM, Li J, Hamsher C, Weiner MM, DeMaria S. Preoperative QTc Interval is Not Associated With Intraoperative Cardiac Events or Mortality in Liver Transplantation Patients. Journal of Cardiothoracic and Vascular Anesthesia. PMID 30097315 DOI: 10.1053/J.Jvca.2018.06.002  0.3
2018 Joseph TT, DiMeglio M, Huffenberger A, Laudanski K. Behavioural patterns of electrolyte repletion in intensive care units: lessons from a large electronic dataset. Scientific Reports. 8: 11915. PMID 30093668 DOI: 10.1038/S41598-018-30444-3  0.32
2018 Joseph TT, Hénin J. Molecular Mechanics Parameterization of Anesthetic Molecules. Methods in Enzymology. 602: 61-76. PMID 29588041 DOI: 10.1016/Bs.Mie.2018.01.003  0.338
2018 Riegelhaupt PM, Woll KA, Joseph TT, Vaidya KA, Nimigean CM, Eckenhoff RG. Identification of a Modulatory Site of Action for the Volatile Anesthetic Isoflurane in TREK1 Tandem Pore Potassium Channels Biophysical Journal. 114: 487a-488a. DOI: 10.1016/J.Bpj.2017.11.2675  0.576
2018 Joseph TT, Eckenhoff RG, Brannigan G. The pH Dependence of Ketamine Binding to G-Protein Coupled Receptors Biophysical Journal. 114: 226a. DOI: 10.1016/J.Bpj.2017.11.1260  0.755
2017 Wax DB, McCormick PJ, Joseph TT, Levin MA. An Automated Critical Event Screening and Notification System to Facilitate Preanesthesia Record Review. Anesthesia and Analgesia. PMID 29053113 DOI: 10.1213/Ane.0000000000002141  0.313
2017 Levin MA, Joseph TT, Jeff JM, Nadukuru R, Ellis SB, Bottinger EP, Kenny EE. iGAS: A Framework for Using Electronic Intraoperative Medical Records for Genomic Discovery. Journal of Biomedical Informatics. PMID 28193464 DOI: 10.1016/J.Jbi.2017.02.005  0.319
2016 Joseph TT, Mincer JS. Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel. Plos One. 11: e0158795. PMID 27403526 DOI: 10.1371/Journal.Pone.0158795  0.545
2016 Joseph TT, Gal JS, DeMaria S, Lin HM, Levine AI, Hyman JB. A Retrospective Study of Success, Failure, and Time Needed to Perform Awake Intubation. Anesthesiology. PMID 27111535 DOI: 10.1097/Sa.0000000000000266  0.319
2012 Joseph TT, Osman R. Convergent transmission of RNAi guide-target mismatch information across Argonaute internal allosteric network. Plos Computational Biology. 8: e1002693. PMID 23028290 DOI: 10.1371/Journal.Pcbi.1002693  0.613
2012 Joseph TT, Osman R. Thermodynamic basis of selectivity in guide-target-mismatched RNA interference. Proteins. 80: 1283-98. PMID 22275138 DOI: 10.1002/Prot.24025  0.6
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