Daniel P. Dowling, Ph.D.
Affiliations: | University of Massachusetts, Boston, Boston, MA |
Area:
structure-mechanism of hydrolytic metalloenzymesWebsite:
http://www.dpdowlinglab.net/index.html/Google:
"Daniel Dowling"Parents
Sign in to add mentor| David W. Christianson | grad student | 2009 | Penn | |
| (Structural studies of two related metallohydrolases: human histone deacetylase 8 and malarial arginase.) | ||||
| Catherine L. Drennan | post-doc | MIT | ||
Children
Sign in to add trainee| Andrew D. Gnann | grad student | U Mass Boston (Crystallography Tree) | |
| Reyaz Gonzalez | grad student | 2018- | University of Massachusetts - Boston |
| Jeremy J.M. Liew | grad student | 2018- | U Mass Boston |
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Publications
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| Knapp M, Jo M, Henthorn CL, et al. (2024) Chlorophyllase from Reveals an Emerging Model for Controlling Chlorophyll Hydrolysis. Acs Bio & Med Chem Au. 4: 353-370 |
| Gonzalez R, Soule J, Phan N, et al. (2024) Structural, biophysical, and biochemical insights into C-S bond cleavage by dimethylsulfone monooxygenase. Proceedings of the National Academy of Sciences of the United States of America. 121: e2401858121 |
| Liew JJM, Wicht DK, Gonzalez R, et al. (2024) Current understanding of enzyme structure and function in bacterial two-component flavin-dependent desulfonases: cleaving C-S bonds of organosulfur compounds. Archives of Biochemistry and Biophysics. 110048 |
| Tian J, Boggs DG, Donnan PH, et al. (2023) The NADH recycling enzymes TsaC and TsaD regenerate reducing equivalents for Rieske oxygenase chemistry. The Journal of Biological Chemistry. 105222 |
| Gnann AD, Marincin K, Frueh DP, et al. (2022) Dynamics and mechanistic interpretations of nonribosomal peptide synthetase cyclization domains. Current Opinion in Chemical Biology. 72: 102228 |
| Gnann AD, Xia Y, Soule J, et al. (2022) High-resolution structures of a siderophore-producing cyclization domain from Yersinia pestis offer a refined proposal of substrate binding. The Journal of Biological Chemistry. 102454 |
| Lee YJ, Dai N, Müller SI, et al. (2021) Pathways of thymidine hypermodification. Nucleic Acids Research |
| Liew JJM, El Saudi I, Nguyen SV, et al. (2021) Structures of the alkanesulfonate monooxygenase MsuD provide insight into C-S bond cleavage, substrate scope, and an unexpected role for the tetramer. The Journal of Biological Chemistry. 100823 |
| Soule J, Gnann AD, Gonzalez R, et al. (2019) Structure and function of the two-component flavin-dependent methanesulfinate monooxygenase within bacterial sulfur assimilation. Biochemical and Biophysical Research Communications |
| Grell TAJ, Bell BN, Nguyen C, et al. (2018) Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity. Protein Science : a Publication of the Protein Society |