David W. Christianson
Affiliations: | Chemistry | University of Pennsylvania, Philadelphia, PA, United States |
Area:
structure-mechanism of hydrolytic metalloenzymesWebsite:
http://webdev.chem.upenn.edu/chem/research/faculty.php?id=15Google:
"David Christianson"Parents
Sign in to add mentor| William N. Lipscomb | grad student | 1987 | Harvard | |
| (Structure-function studies of carboxypeptidase A) | ||||
Children
Sign in to add trainee| Satish K. Nair | grad student | 1994 | Penn |
| Jonathan M. Caruthers | grad student | 2000 | Penn |
| John D. Cox | grad student | 2000 | Penn |
| Chiana M. Paschall | grad student | 2000 | Penn |
| Chu-Young Kim | grad student | 2001 | Penn |
| Evis P. Cama | grad student | 2003 | Penn |
| German A. Gomez | grad student | 2006 | Penn |
| Kevin Jude | grad student | 2007 | Penn |
| Ekaterina Shishova | grad student | 2007 | Penn |
| L. S. Vedula | grad student | 2007 | Penn |
| Heather A. Gennadios | grad student | 2008 | Penn |
| Daniel P. Dowling | grad student | 2009 | Penn |
| Julie A. Aaron | grad student | 2010 | Penn |
| Patrick M. Lombardi | grad student | 2006-2011 | Penn |
| Yang Hai | grad student | 2011-2016 | Penn |
| Trey A Ronnebaum | post-doc | 2018- | Penn |
| Kathryn Cole | post-doc | 2009-2011 | Penn |
BETA: Related publications
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Publications
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| Osika KR, Gaynes MN, Christianson DW. (2025) Crystal Structure and Catalytic Mechanism of Drimenol Synthase, a Bifunctional Terpene Cyclase-Phosphatase. Biorxiv : the Preprint Server For Biology |
| Wenger ES, Christianson DW. (2024) Structure of Bifunctional Variediene Synthase Yields Unique Insight on Biosynthetic Diterpene Assembly and Cyclization. Biorxiv : the Preprint Server For Biology |
| Gaynes MN, Osika KR, Christianson DW. (2024) Structure and Function of Sabinene Synthase, a Monoterpene Cyclase That Generates a Highly Strained [3.1.0] Bicyclic Product. Biochemistry |
| Christianson DW. (2024) Chemical Versatility in Catalysis and Inhibition of the Class IIb Histone Deacetylases. Accounts of Chemical Research. 57: 1135-1148 |
| Eaton SA, Christianson DW. (2024) Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of -Isozizaene Synthase into α-Bisabolol Synthase. Biochemistry |
| Gaynes MN, Ronnebaum TA, Schultz K, et al. (2024) Structure of the prenyltransferase in bifunctional copalyl diphosphate synthase from Penicillium fellutanum reveals an open hexamer conformation. Journal of Structural Biology. 216: 108060 |
| Watson PR, Stollmaier JG, Christianson DW. (2023) Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism. The Journal of Biological Chemistry. 299: 105228 |
| Watson PR, Christianson DW. (2023) Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen . Biochemistry |
| Watson PR, Stollmaier JG, Christianson DW. (2023) Crystal Structure of Histone Deacetylase 6 Complexed with ( )-Lipoic Acid, an Essential Cofactor in Central Carbon Metabolism. Biorxiv : the Preprint Server For Biology |
| Watson PR, Gupta S, Hosseinzadeh P, et al. (2023) Macrocyclic Octapeptide Binding and Inferences on Protein Substrate Binding to Histone Deacetylase 6. Acs Chemical Biology |