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Kirsten M. Raehal

Affiliations: 
The Scripps Research Institute, Scripps Florida 
Area:
G protein-coupled receptors, opioids, arrestins, pain, drugs of abuse
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Parents

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Edward J. Bilsky grad student The University of Northern Colorado
Laura M. Bohn grad student The Ohio State University College of Medicine
Laura M. Bohn post-doc The Scripps Reserach Institute, Scripps Florida

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Publications

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Raehal KM, Bohn LM. (2014) β-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia. Handbook of Experimental Pharmacology. 219: 427-43
Zhou H, Chisari M, Raehal KM, et al. (2012) GIRK channel modulation by assembly with allosterically regulated RGS proteins. Proceedings of the National Academy of Sciences of the United States of America. 109: 19977-82
Nguyen PT, Schmid CL, Raehal KM, et al. (2012) β-arrestin2 regulates cannabinoid CB1 receptor signaling and adaptation in a central nervous system region-dependent manner. Biological Psychiatry. 71: 714-24
Raehal KM, Schmid CL, Groer CE, et al. (2011) Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance. Pharmacological Reviews. 63: 1001-19
Tarselli MA, Raehal KM, Brasher AK, et al. (2011) Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain. Nature Chemistry. 3: 449-53
Raehal KM, Bohn LM. (2011) The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics. Neuropharmacology. 60: 58-65
Fei G, Raehal K, Liu S, et al. (2010) Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse. The Journal of Pharmacology and Experimental Therapeutics. 334: 333-40
Raehal KM, Schmid CL, Medvedev IO, et al. (2009) Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6. Drug and Alcohol Dependence. 104: 187-96
Gupta A, Rozenfeld R, Gomes I, et al. (2008) Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies. The Journal of Biological Chemistry. 283: 10735-44
Schmid CL, Raehal KM, Bohn LM. (2008) Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 1079-84
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