Irwin M. Chaiken
Affiliations: | Biochemistry | Drexel University College of Medicine, Philadelphia, PA, United States |
Area:
protein recognition, protein machine that controls HIV-1 cell entry into host cellsWebsite:
https://www.drexelmed.edu/Home/AboutOurFaculty/IrwinChaiken.aspxGoogle:
"Irwin M. Chaiken"Bio:
http://www.biomed.drexel.edu/content/news_events/display_event_print.cfm?EVENT_ID=157
http://www.ibbr.umd.edu/sites/default/files/event/Dr%20Irwin%20Chaiken%20CV.pdf
Parents
Sign in to add mentor| Emil L. Smith | grad student | 1968 | UCLA | |
| (Studies of the Catalytic Center of Papain) | ||||
| Christian B. Anfinsen | post-doc | 1969-1970 | NIH | |
Children
Sign in to add trainee| Meirav Zaks-Zilberman | grad student | 2008 | Drexel Medical School |
| Syna K. Gift | grad student | 2011 | Drexel Medical School |
| Karyn McFadden | grad student | 2011 | Drexel Medical School |
| Sinan F. Tuzer | grad student | 2012 | Drexel Medical School |
| Shiyu Zhang | grad student | 2015-2021 | Drexel Medical School |
| Yechiel Shai | post-doc | 1988 | NIH |
| Hosahudya N. Gopi | post-doc | 2004-2007 | Drexel |
BETA: Related publications
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Publications
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| Gupta M, Canziani G, Ang CG, et al. (2023) Pharmacophore Variants of the Macrocyclic Peptide Triazole Inactivator of HIV-1 Env. Research Square |
| Cusimano GM, Gary EN, Bell MR, et al. (2022) Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1. Journal of Immunology (Baltimore, Md. : 1950). 209: 118-127 |
| Zhang S, Holmes AP, Dick A, et al. (2021) Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators. Retrovirology. 18: 31 |
| Ang CG, Carter E, Haftl A, et al. (2021) Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus-Cell Entry. Microorganisms. 9 |
| Gaffney A, Nangarlia A, Ang CG, et al. (2021) HIV-1 Env-Dependent Cell Killing by Bifunctional Small-Molecule/Peptide Conjugates. Acs Chemical Biology |
| Parajuli B, Acharya K, Nangarlia A, et al. (2020) Identification of a glycan cluster in gp120 essential for irreversible HIV-1 lytic inactivation by a lectin-based recombinantly engineered protein conjugate. The Biochemical Journal |
| Gossert ST, Parajuli B, Chaiken I, et al. (2020) Roles of Variable Linker Length in Dual Acting Virucidal Entry Inhibitors on HIV-1 Potency via On-the-fly Free Energy Molecular Simulations. Protein Science : a Publication of the Protein Society |
| Prévost J, Tolbert WD, Medjahed H, et al. (2020) The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site. Mbio. 11 |
| Ang CG, Hossain MA, Rajpara M, et al. (2020) Metastable HIV-1 Surface Protein Env Sensitizes Cell Membranes to Transformation and Poration by Dual-Acting Virucidal Entry Inhibitors. Biochemistry |
| Aneja R, Grigoletto A, Nangarlia A, et al. (2019) Pharmacokinetic stability of macrocyclic peptide triazole HIV-1 inactivators alone and in liposomes. Journal of Peptide Science : An Official Publication of the European Peptide Society. e3155 |